Weiguanliu Zhang, Christina D Orrú, Aaron Foutz, Mingxuan Ding, Jue Yuan, Syed Zahid Ali Shah, Jing Zhang, Keisi Kotobelli, Maria Gerasimenko, Tricia Gilliland, Wei Chen, Michelle Tang, Mark Cohen, Jiri Safar, Bin Xu, Dao-Jun Hong, Li Cui, Andrew G Hughson, Lawrence B Schonberger, Curtis Tatsuoka, Shu G Chen, Justin J Greenlee, Zerui Wang, Brian S Appleby, Byron Caughey, Wen-Quan Zou
Definitive diagnosis of sporadic Creutzfeldt-Jakob disease (sCJD) relies on the examination of brain tissues for the pathological prion protein (PrPSc ). Our previous study revealed that PrPSc -seeding activity (PrPSc -SA) is detectable in skin of sCJD patients by an ultrasensitive PrPSc seed amplification assay (PrPSc -SAA) known as real-time quaking-induced conversion (RT-QuIC). A total of 875 skin samples were collected from 2 cohorts (1 and 2) at autopsy from 2-3 body areas of 339 cases with neuropathologically confirmed prion diseases and non-sCJD controls...
January 17, 2024: Acta Neuropathologica