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Breast conserving therapy

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https://www.readbyqxmd.com/read/29141779/five-field-imrt-class-solutions-and-dosimetric-planning-guidelines-for-implementing-accelerated-partial-breast-irradiation
#1
Sarah Quirk, Petra Grendarova, Michael Roumeliotis
PURPOSE: A comprehensive set of planning guidelines was developed to aid in achieving reproducible dosimetric results for external beam accelerated partial breast irradiation (APBI). The methodology for the development of class solutions for dosimetric planning of the APBI technique, including dose constraint recommendations, is presented for target coverage and conformity as well as normal tissues. METHODS AND MATERIALS: A conservative patient setup was simulated on a linear accelerator, and a comprehensive arrangement of gantry and couch angles was measured for clearance...
September 28, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29139613/nipple-sparing-mastectomy-as-treatment-for-patients-with-ductal-carcinoma-in%C3%A2-situ-a-10-year-follow-up-study
#2
Víctor Lago, Vincenzo Maisto, Julia Gimenez-Climent, Jose Vila, Carlos Vazquez, Rafael Estevan
The objective was to determine the 10-year oncological safety of nipple-sparing mastectomy (NSM) in patients diagnosed with ductal carcinoma in situ (DCIS). The use of NSM preserves the nipple-areola complex (NAC). As residual fibroglandular breast tissue can remain behind the spared NAC, its use for patient with breast cancer is controversial. The oncologic outcomes and complication rates after performing NSM compared to other techniques are still under debate and a concern when treating patients with breast cancer...
November 15, 2017: Breast Journal
https://www.readbyqxmd.com/read/29132561/surgical-intervention-for-lymphedema
#3
REVIEW
Kristalyn Gallagher, Kathleen Marulanda, Stephanie Gray
Lymphedema is a chronic, progressive disease with no curative treatment. Breast cancer therapy is the most common cause of secondary lymphedema in the developed world. Treatment includes nonsurgical and surgical strategies. Conservative measures are reserved for subclinical lymphedema. Surgical options are divided into physiologic (to restore function) and reductive (to remove diseased tissue). Early stage disease is managed with physiologic procedures. Reductive treatment is reserved for moderate to severe staged disease owing to high morbidity...
January 2018: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/29132557/triple-negative-breast-cancer-who-should-receive-neoadjuvant-chemotherapy
#4
REVIEW
Lubna N Chaudhary, K Hope Wilkinson, Amanda Kong
Progress in the treatment of triple-negative breast cancer remains an important challenge. Given the aggressive biology and high risk of distant recurrence, systemic chemotherapy is warranted in most patients. Neaodjuvant chemotherapy benefits patients with locally advanced disease by downsizing the tumor and increasing the probability of breast-conserving surgery. Clinical and pathologic responses provide important prognostic information, which makes neoadjuvant therapy an attractive approach for all patients with triple-negative breast cancer...
January 2018: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/29130001/are-patients-traveling-for-intraoperative-radiation-therapy
#5
Kelsey E Larson, Stephanie A Valente, Chirag Shah, Rahul D Tendulkar, Sheen Cherian, Courtney Yanda, Chao Tu, Jessica Echle, Stephen R Grobmyer
Purpose: One benefit of intraoperative radiation therapy (IORT) is that it usually requires a single treatment, thus potentially eliminating distance as a barrier to receipt of whole breast irradiation. The aim of this study was to evaluate the distance traveled by IORT patients at our institution. Methods: Our institutional prospective registry was used to identify IORT patients from 10/2011 to 2/2017. Patient's home zip code was compared to institution zip code to determine travel distance...
2017: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/29127538/the-shifting-paradigm-for-breast-cancer-surgery-in-patients-undergoing-neoadjuvant-chemotherapy
#6
Olga Kantor, Gaurav Ajmani, Chi-Hsiung Wang, Avisek Datta, Katharine Yao
INTRODUCTION: Surgical therapy for newly diagnosed breast cancer has changed over the past decade, but these trends have not been well documented in patients undergoing neoadjuvant therapy (NAC). METHODS: In a retrospective cohort study of the National Cancer Database (NCDB), we selected 285,514 women with clinical stage I-III breast cancer who underwent NAC or adjuvant therapy (AC) from 2006 to 2014. Breast-conserving surgery (BCS), unilateral mastectomy (UM), and bilateral mastectomy (BM) rates were compared between patients undergoing NAC and AC...
November 10, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29123573/conformity-index-and-homogeneity-index-of-the-postoperative-whole-breast-radiotherapy
#7
Deva Petrova, Snezana Smickovska, Emilija Lazarevska
BACKGROUND: The treatment of breast cancer involves a multidisciplinary approach in which radiotherapy plays a key role. AIM: The conformity index and the homogeneity index are two analysis tools of a treatment plan using conformal radiotherapy. The purpose of this article is an analysis of these two parameters in the assessment of the treatment plans in 58 patients undergoing postoperative radiotherapy of the whole breast. MATERIALS AND METHODS: All 58 patients participating in the study had a conservatively treated early-stage breast cancer...
October 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29121898/clinicopathologic-and-prognostic-features-of-breast-cancer-in-young-women-a-series-from-north-of-morocco
#8
Joaira Bakkach, Mohamed Mansouri, Touria Derkaoui, Ali Loudiyi, Mohamed Fihri, Samia Hassani, Amina Barakat, Naima Ghailani Nourouti, Mohcine Bennani Mechita
BACKGROUND: Literature data reported a higher frequency of breast cancer in young women (BCYW) in developing countries. BCYW is associated with delayed diagnosis, aggressive biology and poor prognosis. However, our knowledge of biological profile, treatment received and outcome of young patients is still limited in Morocco. We propose to analyze clinicopathologic, therapeutic and prognostic features of BCYW among a series of patients native and/or inhabitant of North of Morocco. METHODS: We carried out a retro-prospective study of 331 infiltrating breast cancer cases registered between January 2010 and December 2015...
November 9, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/29116237/advantages-of-a-technique-using-two-50-degree-arcs-in-simultaneous-integrated-boost-radiotherapy-for-left-sidebreast-cancer
#9
Dan Xi, Yun Ding, Rui Hu, Wendong Gu, Jinming Mu, Qilin Li
This study evaluated radiotherapy techniques with 15 cases for simultaneous integrated boost to treat whole left breast and tumor bed following breast conserving surgery. Treatment plans were generated using three techniques: volumetric modulated arc therapy (VMAT) with a partial arc of 190° (1ARC), VMAT with two tangential mini-arcs of 50° each (2TARC) and intensity modulated radiation therapy with four fixed angle fields (4IMRT). Dosimetric parameters for the whole breast (Target), the boost tumor bed (Boost), and surrounding normal organs were compared...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29113653/trends-in-adherence-to-nccn-guidelines-for-breast-conserving-therapy-in-women-with-stage-i-and-ii-breast-cancer-analysis-of-the-1998-2008-national-cancer-data-base
#10
Jilma L Patrick, Michelle E Hasse, Joe Feinglass, Seema A Khan
OBJECTIVE: To examine temporal trends in guideline adherence for breast cancer local therapy, by race/ethnicity, socioeconomic and insurance status. BACKGROUND: Treatment guidelines recommend breast conserving therapy (BCT) for women with small cancers, but have been unevenly applied. A better understanding of time-trends in guideline adherence may point to interventions for correction. METHODS: Patients with tumors ≤2 cm (n = 1,081,075) were identified from 1123 NCDB hospitals, dividing the interval 1998-2011 into 5 segments...
December 2017: Surgical Oncology
https://www.readbyqxmd.com/read/29105051/tumour-bed-boost-radiotherapy-for-women-after-breast-conserving-surgery
#11
REVIEW
Isabelle Kindts, Annouschka Laenen, Tom Depuydt, Caroline Weltens
BACKGROUND: Breast-conserving therapy, involving breast-conserving surgery followed by whole-breast irradiation and optionally a boost to the tumour bed, is a standard therapeutic option for women with early-stage breast cancer. A boost to the tumour bed means that an extra dose of radiation is applied that covers the initial tumour site. The rationale for a boost of radiotherapy to the tumour bed is that (i) local recurrence occurs mostly at the site of the primary tumour because remaining microscopic tumour cells are most likely situated there; and (ii) radiation can eliminate these causative microscopic tumour cells...
November 6, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29103057/a-dosimetric-comparison-of-double-arc-volumetric-arc-therapy-step-shoot-intensity-modulated-radiotherapy-and-3d-crt-for-left-sided-breast-cancer-radiotherapy-after-breast-conserving-surgery
#12
Jun-Cong Mo, Jin Huang, Wen-Dong Gu, Min Gao, Zhong-Hua Ning, Jin-Ming Mu, Qi-Lin Li, Hong-Lei Pei
OBJECTIVE: To compare the dosimetric and efficiency differences for left-sided breast cancer radiotherapy after breast-conserving surgery among three different planning techniques: double-arc volumetric-modulate arc therapy (VMAT), step-shoot intensity-modulated radiotherapy (sIMRT) and three-dimensional conformal radiation therapy (3D-CRT). MATERIALS AND METHODS: A total of 17 female patients with left-sided breast cancer who underwent breast-conserving surgery were selected; the prescription doses were 50 Gy in 25 fractions...
October 23, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/29102277/short-term-follow-up-mammography-in-breast-conservation-therapy-likely-leads-to-unnecessary-downstream-workup-a-longitudinal-study
#13
Shaakir Hasan, Stephen Abel, LaShondria Simpson-Camp, Meredith Witten, Luis Aguilera, Leslie Teng, Frances Hite Philp, Thomas B Julian, Mark Trombetta, Stephen Karlovits, Michael Cowher
PURPOSE: To analyze the effect of post-radiation therapy (XRT) mammographic timing and radiation technique in relation to additional downstream workup for 569 breast conservation therapy patients treated with adjuvant XRT after their initial surveillance mammogram (MMG). METHODS AND MATERIALS: From January 2011 to December 2014, 569 breast cancer patients treated with breast conservation surgery and adjuvant XRT with a follow-up MMG were reviewed. Patients were stratified by the time interval until their first post-XRT MMG, and by XRT technique-whole breast (472), accelerated partial breast (96), conventional fractionation (373), hypofractionation (94), surgical cavity boosts (407), or no boost (66)...
September 21, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29101985/acr-appropriateness-criteria-%C3%A2-monitoring-response-to-neoadjuvant-systemic-therapy-for%C3%A2-breast-cancer
#14
Priscilla J Slanetz, Linda Moy, Paul Baron, Roberta M diFlorio, Edward D Green, Samantha L Heller, Anna I Holbrook, Su-Ju Lee, Alana A Lewin, Ana P Lourenco, Bethany Niell, Ashley R Stuckey, Sunita Trikha, Nina S Vincoff, Susan P Weinstein, Monica M Yepes, Mary S Newell
Patients with locally advanced invasive breast cancers are often treated with neoadjuvant chemotherapy prior to definitive surgical intervention. The primary aims of this approach are to: 1) reduce tumor burden thereby permitting breast conservation rather than mastectomy; 2) promptly treat possible metastatic disease, whether or not it is detectable on preoperative staging; and 3) potentially tailor future chemotherapeutic decisions by monitoring in-vivo tumor response. Accurate radiological assessment permits optimal management and planning in this population...
November 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29100639/radiation-therapy-after-breast-conserving-surgery-increases-long-term-breast-conservation-for-dcis-patients
#15
EDITORIAL
Orit Kaidar-Person, Icro Meattini, Philip Poortmans
No abstract text is available yet for this article.
October 31, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29096897/current-approaches-to-diagnosis-and-treatment-of-ductal-carcinoma-in-situ-and-future-directions
#16
Randi Ryan, Ossama Tawfik, Roy A Jensen, Shrikant Anant
The presentation and treatment of ductal carcinoma in situ (DCIS) has changed substantially over the years. While previously an incidental pathologic finding in more advanced, palpable tumors, the institution of screening mammography has repositioned this disease entity as one largely diagnosed as a non-palpable lesion, often prior to any invasive disease. As DCIS is a precursor to invasive carcinoma, evolution in the approach to treatment has followed in the footsteps of that for invasive disease, including breast conservation therapy, adjuvant radiation, and use of antihormonal therapy...
2017: Progress in Molecular Biology and Translational Science
https://www.readbyqxmd.com/read/29096643/comparison-of-sentinel-lymph-node-biopsy-guided-by-indocyanine-green-blue-dye-and-their-combination-in-breast-cancer-patients-a-prospective-cohort-study
#17
Jiajia Guo, Houpu Yang, Shu Wang, Yingming Cao, Miao Liu, Fei Xie, Peng Liu, Bo Zhou, Fuzhong Tong, Lin Cheng, Hongjun Liu, Siyuan Wang
BACKGROUND: Recent studies show that near-infrared (NIR) fluorescence imaging using indocyanine green (ICG) has the potential to improve the performance of sentinel lymph node (SLN) mapping. The current cohort study was designed to assess the value of the combination of ICG and methylene blue (MB) dye in patients undergoing SLN biopsy. METHODS: A prospective self-controlled trial was designed to detect the difference in the detection efficacies of ICG, MB, and combined ICG and MB (ICG + MB) navigation methods...
November 2, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29094250/impact-of-an-in-situ-component-on-outcome-after-in-breast-tumor-recurrence-in-patients-treated-with-breast-conserving-therapy
#18
James Laird, Benjamin Lok, Chun Siu, Oren Cahlon, Atif J Khan, Beryl McCormick, Simon N Powell, Hiram Cody, Hannah Yong Wen, Alice Ho, Lior Z Braunstein
BACKGROUND: Among all in-breast tumor recurrences (IBTR) following breast-conserving therapy (BCT), some comprise metachronous new primaries (NPs) while others are true recurrences (TRs). Establishing this distinction remains a challenge. METHODS: We studied 3932 women who underwent BCT for stage I-III breast cancer from 1998 to 2008. Of these, 115 (2.9%) had an IBTR. Excluding patients with inoperable/unresectable recurrences or simultaneous distant metastases, 81 patients with isolated IBTR comprised the study population...
November 1, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29092024/characterization-of-male-breast-cancer-results-of-the-eortc-10085-tbcrc-big-nabcg-international-male-breast-cancer-program
#19
F Cardoso, J M S Bartlett, L Slaets, C H M van Deurzen, E van Leeuwen-Stok, P Porter, B Linderholm, I Hedenfalk, C Schröder, J Martens, J Bayani, C van Asperen, M Murray, C Hudis, L Middleton, J Vermeij, K Punie, J Fraser, M Nowaczyk, I T Rubio, S Aebi, C Kelly, K J Ruddy, E Winer, C Nilsson, L Dal Lago, L Korde, K Benstead, O Bogler, T Goulioti, A Peric, S Litière, K C Aalders, C Poncet, K Tryfonidis, S H Giordano
Background: Male breast cancer (BC) is rare, managed by extrapolation from female BC. The International Male BC Program aims to better characterize and manage this disease. We report the results of part 1, a retrospective-joint-analysis of cases diagnosed during a 20-year-period. Methods: Patients with follow-up and tumor samples, treated between 1990-2010, in 93 centers/nine countries. Samples were centrally analyzed in three labs (UK, NL, US). Results: Of 1822 patients enrolled, 1483 were analyzed; 63...
October 28, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29079937/clinical-risk-score-to-predict-likelihood-of-recurrence-after-ductal-carcinoma-in-situ-treated-with-breast-conserving-surgery
#20
Rinaa S Punglia, Wei Jiang, Stuart R Lipsitz, Melissa E Hughes, Stuart J Schnitt, Michael J Hassett, Larissa Nekhlyudov, Ninah Achacoso, Stephen Edge, Sara H Javid, Joyce C Niland, Richard L Theriault, Yu-Ning Wong, Laurel A Habel
PURPOSE: A majority of women with ductal carcinoma in situ (DCIS) receive breast-conserving surgery (BCS) but then face a risk of ipsilateral breast tumor recurrence (IBTR) which can be either recurrence of DCIS or invasive breast cancer. We developed a score to provide individualized information about IBTR risk to guide treatment decisions. METHODS: Data from 2762 patients treated with BCS for DCIS at centers within the National Comprehensive Cancer Network (NCCN) were used to identify statistically significant non-treatment-related predictors for 5-year IBTR...
October 28, 2017: Breast Cancer Research and Treatment
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