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Breast conserving therapy

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https://www.readbyqxmd.com/read/29338088/margins-in-breast-cancer-how-much-is-enough
#1
REVIEW
Melissa Pilewskie, Monica Morrow
The appropriate negative margin width for women undergoing breast-conserving surgery for both ductal carcinoma in situ (DCIS) and invasive carcinoma is controversial. This review examines the available data on the margin status for invasive breast cancer and DCIS, and highlights the similarities and differences in tumor biology and standard treatments that affect the local recurrence (LR) risk and, therefore, the optimal surgical margin. Consensus guidelines support a negative margin, defined as no ink on tumor, for invasive carcinoma treated with breast-conserving therapy...
January 16, 2018: Cancer
https://www.readbyqxmd.com/read/29335922/breast-conserving-surgery-in-combination-with-intraoperative-radiotherapy-after-previous-external-beam-therapy-an-option-to-avoid-mastectomy
#2
F Thangarajah, J Heilmann, W Malter, S Kunze, S Marnitz, P Mallmann, F Wenz, E Sperk
PURPOSE: Mastectomy is the standard procedure in patients with in-breast tumor recurrence (IBTR) or breast cancer after irradiation of the chest due to Hodgkin's disease. In certain cases a second breast conserving surgery (BCS) in combination with intraoperative radiotherapy (IORT) is possible. To date, data concerning BCS in combination with IORT in pre-irradiated patients are limited. This is the first pooled analysis of this special indication with a mature follow-up of 5 years. METHODS: Patients with IBTR after external beam radiotherapy (EBRT; treated in two centers) for breast cancer were included...
January 15, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29334604/breast-conservation-therapy-versus-mastectomy-in-patients-with-t1-2n1-triple-negative-breast-cancer-pooled-analysis-of-krog-14-18-and-14-23
#3
Kyubo Kim, Hae Jin Park, Kyung Hwan Shin, Jin Ho Kim, Doo Ho Choi, Won Park, Seung Do Ahn, Su Ssan Kim, Dae Yong Kim, Tae Hyun Kim, Jin Hee Kim, Jiyoung Kim
Purpose: The aim of this study is to compare the treatment outcomes of breast conserving surgery (BCS) plus radiotherapy (RT) vs. mastectomy for patients with pT1-2N1 triple negative breast cancer (TNBC). Methods: Using two multicenter retrospective studies on breast cancer, a pooled analysis was performed among 320 patients with pT1-2N1 TNBC. All patients who underwent BCS (n=212) received whole breast RT with or without regional nodal RT, while none who underwent mastectomy (n=108) received it...
January 8, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29331262/can-interrogation-of-tumour-characteristics-lead-us-to-safely-omit-adjuvant-radiotherapy-in-patients-with-early-breast-cancer
#4
I S Bhattacharya, A M Kirby, J M Bliss, C E Coles
Adjuvant radiotherapy after breast-conserving surgery has been an important component of the standard of care for early breast cancer. Improvements in breast cancer care have resulted in a substantial reduction in local relapse rates over recent decades. Although the proportional benefits of adjuvant radiotherapy are similar for different prognostic risk groups of patients, the absolute benefits depend on the risk of relapse and therefore vary considerably between prognostic groups. Radiotherapy is not without risk and for some patients at very low risk of relapse the risks of radiotherapy may outweigh the benefit, leading to potential overtreatment...
January 10, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/29327297/correction-to-breast-conserving-surgery-following-neoadjuvant-therapy-a-systematic-review-on-surgical-outcomes
#5
José H Volders, Vera L Negenborn, Pauline E Spronk, Nicole M A Krekel, Linda J Schoonmade, Sybren Meijer, Isabel T Rubio, M Petrousjka van den Tol
In the original publication of the article, Table 2 was published incorrectly. The corrected Table 2 is given in this erratum. The original article has been corrected.
January 11, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29325808/dutch-breast-reconstruction-guideline
#6
REVIEW
Marc A M Mureau
Treatment of breast cancer is complex and multidisciplinary by nature, with protocols that are updated continuously. During preoperative multidisciplinary team meetings, regularly there is discussion between team members regarding optimal timing and type of breast reconstruction, due to conflicting interests of oncological and reconstructive treatments. Therefore, a multidisciplinary, evidence-based guideline for breast reconstruction in women undergoing breast conserving therapy or mastectomy for breast cancer, or following prophylactic mastectomy was developed by a multidisciplinary working group...
December 27, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29324302/addressing-the-paradox-of-increasing-mastectomy-rates-in-an-era-of-de-escalation-of-therapy-communication-strategies
#7
REVIEW
Mona P Tan, Edibaldo Silva
Breast conservation therapy (BCT) was established as the preferred modality of surgical treatment for early stage breast cancer in the early 1990's. Yet, rising mastectomy rates have been observed over the last decade. This increase is a cause for concern as recent large population-based studies have consistently reported improved breast cancer-specific survival and local control rates with BCT, in comparison with mastectomy. There is a pressing need to formulate strategies to effectively inform both patients and practitioners about current data, in the hope of reversing rising mastectomy rates to optimise survival outcomes...
January 8, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29316049/evaluation-of-cosmetic-outcome-following-breast-conserving-therapy-in-trials-panel-versus-digitalized-analysis-and-the-role-of-proms
#8
Mirelle Lagendijk, Elvira L Vos, Daan Nieboer, Cornelis Verhoef, Evelien M L Corten, Linetta B Koppert
Cosmetic outcome is an important quality of life-related end point following breast-conserving therapy (BCT). To advise on a gold standard, we compare cosmetic outcome evaluated by panel and an objective evaluation (BCCT.core software). Second, patient-reported outcome measures (PROMs) are compared to cosmetic outcome evaluation by panel and BCCT.core. Sixty-eight breast cancer patients were included following BCT between 2007 and 2012. Two independent 6-member panels and two observers using the BCCT.core evaluated cosmetic outcome...
January 8, 2018: Breast Journal
https://www.readbyqxmd.com/read/29312836/malignant-epithelial-transformation-in-phyllodes-tumor-a-population-based-case-series
#9
Ralph L Widya, Myra F Rodrigues, Pauline T Truong, Peter H Watson, Lorna M Weir, Margaret A Knowling, Elaine S Wai
Background Phyllodes tumor (PT) of the breast is an uncommon fibroepithelial neoplasm. Malignant epithelial transformation in PT is rare. This study reports clinicopathologic characteristics and outcomes of patients with malignant epithelial transformation in PT. Methods From an institutional database of 183 patients with newly diagnosed PT referred to a Canadian provincial cancer institution between 1999 and 2014, 11 cases of PT with concomitant in situ or invasive carcinoma were identified. Descriptive analysis was performed to document the characteristics, treatment and outcomes of this cohort...
November 3, 2017: Curēus
https://www.readbyqxmd.com/read/29310606/ethnic-disparities-in-breast-cancer-survival-in-new-zealand-which-factors-contribute
#10
Sandar Tin Tin, J Mark Elwood, Charis Brown, Diana Sarfati, Ian Campbell, Nina Scott, Reena Ramsaroop, Sanjeewa Seneviratne, Vernon Harvey, Ross Lawrenson
BACKGROUND: New Zealand has major ethnic disparities in breast cancer survival with Māori (indigenous people) and Pacific women (immigrants or descended from immigrants from Pacific Islands) faring much worse than other ethnic groups. This paper identified underlying factors and assessed their relative contribution to this risk differential. METHODS: This study involved all women who were diagnosed with primary invasive breast cancer in two health regions, covering about 40% of the national population, between January 2000 and June 2014...
January 8, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29304773/breast-carcinoma-with-21-gene-recurrence-score-lower-than-18-rate-of-locoregional-recurrence-in-a-large-series-with-clinical-follow-up
#11
Gulisa Turashvili, Edi Brogi, Monica Morrow, Maura Dickler, Larry Norton, Clifford Hudis, Hannah Y Wen
BACKGROUND: The 21-gene recurrence score (RS) assay determines the benefit of adding chemotherapy to endocrine therapy for patients with early stage, estrogen receptor (ER)-positive, HER2-negative breast cancer. The RS risk groups predict the likelihood of distant recurrence and have recently been associated with an increased risk of locoregional recurrence (LRR). This study analyzed clinicopathologic features of patients with low RS and LRR. METHODS: In our institutional database, we identified 1396 consecutive female patients with lymph node negative, ER+/HER2- invasive breast carcinoma and low RS (<18) results, treated at our center from 2008 to 2013...
January 6, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29302485/21-gene-recurrence-assay-in-patients-receiving-intraoperative-radiotherapy-are-favorable-characteristics-a-surrogate-for-low-recurrence
#12
Bridget A Oppong, Surupa Sen Gupta, Monique Gary, Patricia Wehner, Mihriye Mete, Danjing Zhao, Sulakshana Seevaratnam, Sonali Rudra, Shawna C Willey
Background: Intraoperative radiotherapy (IORT) has gained momentum for early stage and favorable breast cancers (BC). The 21-gene recurrence assay guides treatment of hormone positive and node-negative BC. Methods: Analysis of 82 invasive BC treated with breast conservation surgery (BCS) and IORT 2013-2015. Data collection included patient demographics, tumor characteristics, nodal status, recurrence test (RS) and adjuvant therapy. Results: The mean age was 68 years...
December 2017: Gland Surgery
https://www.readbyqxmd.com/read/29299647/breast-and-tumour-volume-measurements-in-breast-cancer-patients-using-3-d-automated-breast-volume-scanner-images
#13
M Lagendijk, E L Vos, K P Ramlakhan, C Verhoef, A H J Koning, W van Lankeren, L B Koppert
BACKGROUND: The resection volume in relation to the breast volume is known to influence cosmetic outcome following breast-conserving therapy. It was hypothesised that three-dimensional ultrasonography (3-D US) could be used to preoperatively assess breast and tumour volume and show high association with histopathological measurements. METHODS: Breast volume by the 3D-US was compared to the water displacement method (WDM), mastectomy specimen weight, 3-D MRI and three different calculations for breast volume on mammography...
January 3, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29285378/phase-ii-study-of-neoadjuvant-anthracycline-combined-with-nanoparticle-albumin-bound-paclitaxel-for-human-epidermal-growth-factor-receptor-2-negative-breast-cancer
#14
Emi Ishigami, Masahiro Sakakibara, Junta Sakakibara, Toshiaki Iwase, Shoko Hayama, Takahito Masuda, Ayako Nakagawa, Takeshi Nagashima, Takafumi Sangai, Hiroshi Fujimoto, Masayuki Otsuka
Neoadjuvant chemotherapy (NAC) with anthracyclines followed by taxane chemotherapy has become the standard treatment for patients with locally advanced, operable breast cancer. Recently, the efficacy of nanoparticle albumin-bound paclitaxel (nab-PTX) for metastatic breast cancer was reported. However, there are still few studies of a neoadjuvant regimen including nab-PTX. Thus, the present phase II study evaluated the efficacy and safety of 5-fluorouracil, epirubicin and cyclophosphamide (FEC regimen) followed by nab-PTX as neoadjuvant treatment for operable human epidermal growth factor receptor 2 (HER2)-negative breast cancer...
December 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29285036/selective-radiation-therapy-for-ductal-carcinoma-in-situ-following-breast-conserving-surgery-according-to-age-and-margin-width-korean-radiation-oncology-group-11-04-and-16-02-studies
#15
Kyubo Kim, Jin Hee Kim, Yong Bae Kim, Chang-Ok Suh, Kyung Hwan Shin, Jin Ho Kim, Tae Hyun Kim, So-Youn Jung, Doo Ho Choi, Won Park, Seung Do Ahn, Su Ssan Kim, Ji Woon Yea, Min Kyu Kang, Dong Won Kim, Yi-Jun Kim
Purpose: The optimal indications for omitting adjuvant radiation therapy (RT) after breast-conserving surgery are still controversial in ductal carcinoma in situ (DCIS) of the breast. The purpose of this study was to validate the role of postoperative RT in DCIS patients aged ≤50 years and with tumor margin widths of <1 cm, both of which have been proven to be high-risk features for recurrence in cohorts not receiving RT. Methods: Using two multicenter retrospective studies on DCIS, a pooled analysis was performed among patients aged ≤50 years and with margin widths <1 cm...
December 2017: Journal of Breast Cancer
https://www.readbyqxmd.com/read/29282681/studies-on-dna-damage-repair-and-precision-radiotherapy-for-breast-cancer
#16
Yanhui Jiang, Yimin Liu, Hai Hu
Radiotherapy acts as an important component of breast cancer management, which significantly decreases local recurrence in patients treated with conservative surgery or with radical mastectomy. On the foundation of technological innovation of radiotherapy setting, precision radiotherapy of cancer has been widely applied in recent years. DNA damage and its repair mechanism are the vital factors which lead to the formation of tumor. Moreover, the status of DNA damage repair in cancer cells has been shown to influence patient response to the therapy, including radiotherapy...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29275105/preferred-and-perceived-participation-of-younger-and-older-patients-in-decision-making-about-treatment-for-early-breast-cancer-a-prospective-study
#17
Victoria C Hamelinck, Esther Bastiaannet, Arwen H Pieterse, Cornelis J H van de Velde, Gerrit-Jan Liefers, Anne M Stiggelbout
BACKGROUND: Older patients are believed to prefer a more passive role in treatment decision making, but studies reporting this relation were conducted over a decade ago or were retrospective. We prospectively compared younger (40-64 years) versus older (≥ 65 years) breast cancer patients' preferences for decision-making roles and their perceived actual roles. PATIENTS AND METHODS: A prospective multicenter study was conducted in Leiden, The Hague, and Tilburg over a 2-year period...
November 28, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29274272/the-role-of-the-hedgehog-signaling-pathway-in-cancer-a-comprehensive-review
#18
REVIEW
Ana Marija Skoda, Dora Simovic, Valentina Karin, Vedran Kardum, Semir Vranic, Ljiljana Serman
The Hedgehog (Hh) signaling pathway was first identified in the common fruit fly. It is a highly conserved evolutionary pathway of signal transmission from the cell membrane to the nucleus. The Hh signaling pathway plays an important role in the embryonic development. It exerts its biological effects through a signaling cascade that culminates in a change of balance between activator and repressor forms of glioma-associated oncogene (Gli) transcription factors. The components of the Hh signaling pathway involved in the signaling transfer to the Gli transcription factors include Hedgehog ligands (Sonic Hh [SHh], Indian Hh [IHh], and Desert Hh [DHh]), Patched receptor (Ptch1, Ptch2), Smoothened receptor, Suppressor of fused homolog, kinesin-7, protein kinase A, and cyclic adenosine monophosphate (AMP)...
December 23, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29258457/photosensitive-lichenoid-skin-reaction-to-capecitabine
#19
Rena A Shah, Daniel D Bennett, Mark E Burkard
BACKGROUND: Capecitabine is an oral prodrug of fluorouracil, which is a common agent used in the management of many solid tumor malignancies. Dermatologic reaction is common with various chemotherapy agents but is not commonly reported in the use of capecitabine. When adverse reactions of rashes occur, the offending agent is typically removed. We report here an unusual case of photosensitive lichenoid rash due to capecitabine which is managed conservatively without major alteration in treatment...
December 19, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29249796/atypical-presentation-of-radiation-associated-breast-angiosarcoma-a-case-report-and-review-of-literature
#20
Yvette Farran, Osvaldo Padilla, Karinn Chambers, Alexander Philipovskiy, Zeina Nahleh
BACKGROUND Radiation-associated breast angiosarcoma is a rare clinical entity that is thought to be increasing in incidence. CASE REPORT Here we present the case of a 67-year-old female with a history of left breast invasive ductal carcinoma who received breast conserving surgery and radiation therapy eight years ago. She then presented with a painless mild skin discoloration of the left breast that had been present for over one year. Mammograms and ultrasounds were normal. A punch biopsy and a subsequent excisional biopsy revealed the diagnosis of angiosarcoma...
December 18, 2017: American Journal of Case Reports
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