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Breast conserving therapy

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https://www.readbyqxmd.com/read/29772881/geographic-access-to-radiation-therapy-facilities-and-disparities-of-early-stage-breast-cancer-treatment
#1
Yan Lin, Michael C Wimberly, Patricia Da Rosa, Joseph Hoover, William F Athas
Few studies of breast cancer treatment have focused on the Northern Plains of the United States, an area with a high mastectomy rate. This study examined the association between geographic access to radiation therapy facilities and receipt of breast cancer treatments among early-stage breast cancer patients in South Dakota. Based on 4,209 early-stage breast cancer patients diagnosed between 2001 and 2012 in South Dakota, the study measured geographic proximity to radiation therapy facilities using the shortest travel time for patients to the closest radiation therapy facility...
May 7, 2018: Geospatial Health
https://www.readbyqxmd.com/read/29772517/dynamics-of-the-hazard-for-distant-metastases-after-ipsilateral-breast-tumor-recurrence-according-to-estrogen-receptor-status-an-analysis-of-2851-patients
#2
Massimiliano Gennaro, Serena Di Cosimo, Ilaria Ardoino, Silvia Veneroni, Luigi Mariani, Roberto Agresti, Maria Grazia Daidone, Filippo de Braud, Giovanni Apolone, Elia Biganzoli, Romano Demicheli
BACKGROUND: Breast cancer (BC) patients with ipsilateral breast tumor recurrence (IBTR) are at high risk of developing distant metastases (DM). We aimed to evaluate the risk pattern of developing DM, with respect to the occurrence of IBTR, in a large series of patients homogeneously treated by conservative surgery (QUART) with a considerably long follow-up. METHODS: Piecewise exponential model was used to investigate DM dynamics conditioning on known prognostic factors and IBTR occurrence as time dependent covariate...
May 14, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29761316/impact-of-visual-feedback-on-dose-volume-histograms-for-organs-at-risk-in-postoperative-radiotherapy-with-deep-inspiration-breath-holding-for-patients-treated-with-breast-conserving-therapy-a-planning-study
#3
Keiko Nemoto Murofushi, Masaru Nakajima, Tetsuya Tomita, Minako Sumi, Yasuo Yoshioka, Masahiko Oguchi, Hideyuki Sakurai
BACKGROUND: We evaluated the effectiveness of visual feedback (VF) on radiotherapy with deep inspiration breath-holding (DIBH), and reviewed the dose for organs at risk (OARs). METHODS: Respiratory motions during DIBH for 15 s were monitored during planning computed tomography (CT)-scanning and simulation for 40 patients after breast-conserving surgery from June 2007 to February 2008. For 22 of 40 patients, a goggle-type liquid crystal display monitor was used for VF...
May 14, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/29761001/multiscale-nonlinear-microscopy-and-widefield-white-light-imaging-enables-rapid-histological-imaging-of-surgical-specimen-margins
#4
Michael G Giacomelli, Tadayuki Yoshitake, Lucas C Cahill, Hilde Vardeh, Liza M Quintana, Beverly E Faulkner-Jones, Jeff Brooker, James L Connolly, James G Fujimoto
The ability to histologically assess surgical specimens in real-time is a long-standing challenge in cancer surgery, including applications such as breast conserving therapy (BCT). Up to 40% of women treated with BCT for breast cancer require a repeat surgery due to postoperative histological findings of close or positive surgical margins using conventional formalin fixed paraffin embedded histology. Imaging technologies such as nonlinear microscopy (NLM), combined with exogenous fluorophores can rapidly provide virtual H&E imaging of surgical specimens without requiring microtome sectioning, facilitating intraoperative assessment of margin status...
May 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29757686/predictors-of-unemployment-after-breast-cancer-surgery-a-systematic-review-and-meta-analysis-of-observational-studies
#5
Li Wang, Brian Y Hong, Sean A Kennedy, Yaping Chang, Chris J Hong, Samantha Craigie, Henry Y Kwon, Beatriz Romerosa, Rachel J Couban, Susan Reid, James S Khan, Michael McGillion, Victoria Blinder, Jason W Busse
Purpose Breast cancer surgery is associated with unemployment. Identifying high-risk patients could help inform strategies to promote return to work. We systematically reviewed observational studies to explore factors associated with unemployment after breast cancer surgery. Methods We searched MEDLINE, EMBASE, CINAHL, and PsycINFO to identify studies that explored risk factors for unemployment after breast cancer surgery. When possible, we pooled estimates of association for all independent variables reported by more than one study...
May 14, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29756510/oncoplastic-breast-conserving-surgery-in-iceland-a-population-based-study
#6
E P Palsdottir, S H L Lund, K S A Asgeirsson
BACKGROUND AND AIMS: In Iceland, oncoplastic breast-conservation surgery has been performed since 2008. The aim of this population-based study was to assess and compare the efficacy and patient satisfaction of standard breast-conservation surgery with oncoplastic breast-conservation surgery. MATERIALS AND METHODS: This is a population-based, retrospective, observational cohort study on all women undergoing breast-conservation surgery in Iceland from the 1 January 2008 to 31 December 2014...
May 1, 2018: Scandinavian Journal of Surgery: SJS
https://www.readbyqxmd.com/read/29752474/checkpoint-suppressor-1-suppresses-transcriptional-activity-of-er%C3%AE-and-breast-cancer-cell-proliferation-via-deacetylase-sirt1
#7
Zhaowei Xu, Yangyang Yang, Bowen Li, Yanan Li, Kangkai Xia, Yuxi Yang, Xiahui Li, Miao Wang, Shujing Li, Huijian Wu
Breast cancer is a highly heterogeneous carcinoma in women worldwide, but the underlying mechanisms that account for breast cancer initiation and development have not been fully established. Mounting evidence indicates that Checkpoint suppressor 1 (CHES1) is tightly associated with tumorigenesis and prognosis in many types of cancer. However, the definitive function of CHES1 in breast cancer remains to be explored. Here we showed that CHES1 had a physical interaction with estrogen receptor-α (ERα) and repressed the transactivation of ERα in breast cancer cells...
May 11, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29748884/predictors-of-residual-disease-after-breast-conservation-surgery
#8
Lisa J Findlay-Shirras, Oussama Outbih, Charlene N Muzyka, Katie Galloway, Pamela C Hebbard, Maged Nashed
INTRODUCTION: Breast-conserving therapy is the standard of care for early-stage breast cancer. In the era of multimodality therapy, the debate on the value of revision surgery for compromised margins continues, and high re-excision rates persist despite updated guidelines. Our study sought to identify the local re-excision rate for compromised margins after lumpectomy, and identify predictors of residual disease at re-excision. METHODS: This population-based retrospective cohort study included women with breast cancer who underwent a lumpectomy between 2009 and 2012 in Manitoba, with close (≤ 2 mm) or positive margins that led to re-excision...
May 10, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29748762/predictors-of-surveillance-mammography-outcomes-in-women-with-a-personal-history-of-breast-cancer
#9
Kathryn P Lowry, Lior Z Braunstein, Konstantinos P Economopoulos, Laura Salama, Constance D Lehman, G Scott Gazelle, Elkan F Halpern, Catherine S Giess, Alphonse G Taghian, Janie M Lee
PURPOSE: To identify predictors of poor mammography surveillance outcomes based on clinico-pathologic features. METHODS: This study was HIPAA compliant and IRB approved. We performed an electronic medical record review for a cohort of women with American Joint Committee on Cancer (AJCC) Stage I or II invasive breast cancer treated with breast conservation therapy who developed subsequent in-breast treatment recurrence (IBTR) or contralateral breast cancer (CBC)...
May 10, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29744672/efficacy-and-safety-of-neoadjuvant-treatment-with-bevacizumab-liposomal-doxorubicin-cyclophosphamide-and-paclitaxel-combination-in-locally-regionally-advanced-her2-negative-grade-iii-at-premenopausal-status-breast-cancer-a-phase-ii-study
#10
Ekaterini C Tampaki, Athanasios Tampakis, Constantinos E Alifieris, Dimitrios Krikelis, Anastasia Pazaiti, Michalis Kontos, Dimitrios T Trafalis
BACKGROUND: In the era of personalized therapy, targeted treatment in specific patient populations is mandated. OBJECTIVE: We evaluated the efficacy and safety of neoadjuvant treatment on locally advanced breast cancer (LABC) with a monoclonal agent against vascular endothelial growth factor (VEGF), bevacizumab plus chemotherapy combination of liposomal doxorubicin, cyclophosphamide and paclitaxel (PLAC-B). METHODS: Patients enrolled were at premenopausal status and characterized by human epidermal growth factor receptor 2 (HER2)-negative, hormone-receptor positive (estrogen receptor/progesterone receptor-positive [ER/PR+]) or triple-negative (TNBC), LABC (T > 3 cm), with high-grade ductal carcinoma...
May 9, 2018: Clinical Drug Investigation
https://www.readbyqxmd.com/read/29736399/once-weekly-hypofractionated-radiotherapy-for-breast-cancer-in-elderly-patients-efficacy-and-tolerance-in-486-patients
#11
Javier Sanz, Min Zhao, Nuria Rodríguez, Raquel Granado, Palmira Foro, Ana Reig, Ismael Membrive, Manuel Algara
Purpose: Radiation therapy is a key treatment of breast cancer. Elderly patients with associated diseases that modify their performance status do not tolerate long periods of daily irradiation. The objective of this study is to analyze the results of weekly hypofractionated treatment in these patients. Material and Methods: Between 1992 and 2016, we included 486 elderly patients presenting concomitant pathology or sociofamilial problems in which it was not feasible to propose conventional treatment...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29734046/impact-of-neoadjuvant-chemotherapy-and-pathological-complete-response-on-eligibility-for-breast-conserving-surgery-in-patients-with-early-breast-cancer-a-meta-analysis
#12
Carmen Criscitiello, Mehra Golshan, William T Barry, Giulia Viale, Stephanie Wong, Michele Santangelo, Giuseppe Curigliano
PURPOSE: We conducted a meta-analysis of randomised trials evaluating pathological complete response (pCR) and surgical outcomes after neoadjuvant systemic therapy (NST) in patients with early breast cancer (EBC). PATIENTS AND METHODS: The primary outcome was breast-conserving surgery (BCT) rate. Secondary outcomes were pCR rate and association to BCT. Meta-analyses were performed using random effects models that use inverse-variance weighting for each treatment arm based on evaluable patients...
May 4, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29733541/a-multicenter-phase-ii-trial-of-neoadjuvant-letrozole-plus-low-dose-cyclophosphamide-in-postmenopausal-patients-with-estrogen-receptor-positive-breast-cancer-jbcrg-07-therapeutic-efficacy-and-clinical-implications-of-circulating-endothelial-cells
#13
Takayuki Ueno, Norikazu Masuda, Shunji Kamigaki, Takashi Morimoto, Futoshi Akiyama, Masafumi Kurosumi, Hitoshi Tsuda, Yoshiki Mikami, Sunao Tanaka, Satoshi Morita, Masakazu Toi
Neoadjuvant endocrine therapy has been reported to decrease tumor size, which leads to increased breast conservation rates. To improve the clinical response, metronomic chemotherapy with endocrine therapy is a promising strategy. A multicenter phase II single-arm neoadjuvant trial with letrozole and cyclophosphamide was conducted. Eligibility criteria included postmenopausal status, T2-4 N0-1, and estrogen receptor-positive breast carcinoma. Letrozole (2.5 mg) plus cyclophosphamide (50 mg) was given orally once a day for 24 weeks...
May 7, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29733019/prognostic-factors-of-treatment-failure-for-early-breast-cancer-after-breast-conserving-surgery
#14
Mohammad Aldaqaf, Eugen Bratucu
Introduction: Breast cancer is the most common cancer in women in developed Western countries and is becoming even more significant in many developing countries. Breast conserving surgery (BCS) has become the gold standard for patients with early breast cancer (EBC) (Stage I, II) with an appropriate patient selection. Important risk factors for treatment failure, include margin status, age, tumour multicentricity and use of radiotherapy and adjuvant hormone therapy. AIM: To establish the prognostic variables for ipsilateral breast tumour recurrence (IBTR) in EBC after BCS and the survival rate...
March 2018: Chirurgia
https://www.readbyqxmd.com/read/29727326/prognostic-impact-of-breast-conserving-therapy-versus-mastectomy-of-brca1-2-mutation-carriers-compared-with-noncarriers-in-a-consecutive-series-of-young-breast-cancer-patients
#15
Alexandra J van den Broek, Marjanka K Schmidt, Laura J van 't Veer, Hester S A Oldenburg, Emiel J Rutgers, Nicola S Russell, Vincent T H B M Smit, Adri C Voogd, Linetta B Koppert, Sabine Siesling, Jan J Jobsen, Pieter J Westenend, Flora E van Leeuwen, Rob A E M Tollenaar
OBJECTIVE: To investigate the effects of different types of surgery on breast cancer prognosis in germline BRCA1/BRCA2 mutation carriers compared with noncarriers. SUMMARY OF BACKGROUND DATA: Although breast-conserving therapy (breast-conserving surgery followed by radiotherapy) has been associated with more local recurrences than mastectomy, no differences in overall survival have been found in randomized trials performed in the general breast cancer population...
May 1, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29723396/risk-factors-for-locoregional-disease-recurrence-after-breast-conserving-therapy-in-patients-with-breast-cancer-treated-with-neoadjuvant-chemotherapy-an-international-collaboration-and-individual-patient-meta-analysis
#16
Antonios Valachis, Eleftherios P Mamounas, Elizabeth A Mittendorf, Naoki Hayashi, Makoto Ishitobi, Clara Natoli, Florian Fitzal, Isabel T Rubio, Daniel G Tiezzi, Hee-Chul Shin, Stewart J Anderson, Kelly K Hunt, Naoko Matsuda, Shozo Ohsumi, Athina Totomi, Cecilia Nilsson
BACKGROUND: Several studies have reported a high risk of local disease recurrence (LR) and locoregional disease recurrence (LRR) in patients with breast cancer after neoadjuvant chemotherapy (NCT) and breast-conserving therapy (BCT). The objective of the current study was to identify potential risk factors for LR and LRR after NCT and BCT. METHODS: Individual patient data sets from 9 studies were pooled. The outcomes of interest were the occurrence of LR and/or LRR...
May 3, 2018: Cancer
https://www.readbyqxmd.com/read/29721467/practical-consensus-recommendations-for-tumor-margins-and-breast-conservative-surgery
#17
R Sarin, S P Somsekhar, R Kumar, Gupta Pawan, Jain Sumeet, Jindal Pramoj, Zamre Vaishali, Pasha Firoz, P M Parikh, S Aggarwal, R Koul
My suggestion: There is no difference in survival of breast cancer patients treated with either mastectomy or with breast conservation therapy combined with external beam radiotherapy. A positive margin (s) is an important factor contributing to the increased risk of local recurrence. However, in published literature, there is a lack of consensus on the definition of acceptable margin (s). As a result decision process about need for re-excision after positive margins remains uncrear.
April 2018: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/29719816/local-and-regional-breast-cancer-recurrences-salvage-therapy-options-in-the-new-era-of-molecular-subtypes
#18
REVIEW
Yazid Belkacemi, Nivin E Hanna, Clementine Besnard, Soufya Majdoul, Joseph Gligorov
Isolated local or regional recurrence of breast cancer (BC) leads to an increased risk of metastases and decreased survival. Ipsilateral breast recurrence can occur at the initial tumor bed or in another quadrant of the breast. Depending on tumor patterns and molecular subtypes, the risk and time to onset of metastatic recurrence differs. HER2-positive and triple-negative (TNG) BC have a risk of locoregional relapse between six and eight times than luminal A. Thus, the management of local and locoregional relapses must take into account the prognostic factors for metastatic disease development...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29719429/prescribing-practices-of-endocrine-therapy-for-ductal-carcinoma-in-situ-in-british-columbia
#19
A T Chaudhry, T A Koulis, C Speers, R A Olson
Purpose: The mainstay of treatment for ductal carcinoma in situ (dcis) involves surgery in the form of mastectomy or lumpectomy. Inconsistency in the use of endocrine therapy (et) for dcis is evident worldwide. We sought to assess the variation in et prescribing for patients with dcis across a population-based radiotherapy (rt) program and to identify variables that predict its use. Methods: Data from a breast cancer database were obtained for women diagnosed with dcis in British Columbia from 2009 to 2014...
April 2018: Current Oncology
https://www.readbyqxmd.com/read/29709338/omitting-radiotherapy-in-women-%C3%A2-65-years-with-low-risk-early-breast-cancer-after-breast-conserving-surgery-and-adjuvant-endocrine-therapy-is-safe
#20
Åsa Wickberg, Göran Liljegren, Fredrika Killander, Henrik Lindman, Judith Bjöhle, Michael Carlberg, Carl Blomqvist, Johan Ahlgren, Kenneth Villman
PURPOSE: The aim of this study was to verify if radiotherapy (RT) safely can be omitted in older women treated for estrogen-receptor positive early breast cancer with breast-conserving surgery (BCS) and endocrine therapy (ET). PATIENTS AND METHODS: Eligibility criteria were: consecutive patients with age ≥65 years, BCS + sentinel node biopsy, clear margins, unifocal T1N0M0 breast cancer tumor, Elston-Ellis histological grade 1 or 2 and estrogen receptor-positive tumor...
April 13, 2018: European Journal of Surgical Oncology
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