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Breast conservation treatment

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https://www.readbyqxmd.com/read/29457684/poorly-differentiated-neuroendocrine-carcinoma-of-the-breast-with-merkel-cell-features
#1
Emily L Albright, Matthew E Keeney, Amani Bashir, Ronald J Weigel
Neuroendocrine carcinoma of the breast is a rare tumor subtype comprising less than 1% of breast cancers in the United States. Merkel cell features within this rare subtype are even rarer. We report a neuroendocrine breast carcinoma with Merkel cell features. The patient underwent breast conservation therapy and a sentinel lymph node biopsy. Unfortunately, the tumor was extremely aggressive and at 5 weeks postoperatively she presented with widely metastatic disease. Due to the aggressive nature of this tumor, we reviewed the literature and treatment options for this rare variant of a rare subtype...
February 19, 2018: Breast Journal
https://www.readbyqxmd.com/read/29456472/electron-beam-intraoperative-radiotherapy-eliot-in-pregnant-women-with-breast-cancer-from-in-vivo-dosimetry-to-clinical-practice
#2
Maria Leonardi, Agnese Cecconi, Rosa Luraschi, Elena Rondi, Federica Cattani, Roberta Lazzari, Anna Morra, Santos Soto, Vanna Zanagnolo, Viviana Galimberti, Oreste Gentilini, Fedro Peccatori, Barbara Jereczek-Fossa, Roberto Orecchia
Background: The aim of this study was to confirm our preliminary results with in vivo dosimetry in non-pregnant breast cancer patients receiving electron beam intraoperative radiotherapy (ELIOT) and to report on the first treatment in a pregnant woman. Patients and Methods: Following our previous experience, 5 non-pregnant patients receiving ELIOT to the tumor bed after breast-conserving surgery (BCS) were studied with thermoluminescent dosimeters positioned in the subdiaphragmatic region, within the uterus, and in the ovarian region...
December 2017: Breast Care
https://www.readbyqxmd.com/read/29456470/is-mastectomy-oncologically-safer-than-breast-conserving-treatment-in-early-breast-cancer
#3
REVIEW
Fabian Riedel, André Hennigs, Sarah Hug, Benedikt Schaefgen, Christof Sohn, Florian Schuetz, Michael Golatta, Jörg Heil
Aim: To describe and discuss the evidence for oncological safety of different procedures in oncological breast surgery, i.e. breast-conserving treatment versus mastectomy. Methods: Literature review and discussion. Results: Oncological safety in breast cancer surgery has many dimensions. Breast-conserving treatment has been established as the standard surgical procedure for primary breast cancer and fits to the preferences of most breast cancer patients concerning oncological safety and aesthetic outcome...
December 2017: Breast Care
https://www.readbyqxmd.com/read/29454174/mastectomy-patterns-but-not-rates-are-changing-in-the-treatment-of-early-breast-cancer-experience-of-a-single-european-institution-on-2315-consecutive-patients
#4
Alessandro Fancellu, Valeria Sanna, Pietrina Cottu, Cladio F Feo, Antonio M Scanu, Giulia Farina, Antonio Bulla, Angela Spanu, Panagiotis Paliogiannis, Alberto Porcu
BACKGROUND: Recent literature reports that rates of mastectomy are increasing in early breast cancer. However, data from European institutions are limited and revealed conflicting results. We report on 15-year trends of mastectomy, mastectomy plus immediate reconstruction and contralateral prophylactic mastectomy (CPM) at an academic institution. METHODS: We identified women diagnosed with unilateral early breast cancer at stage 0-IIa, with tumour size ≤ 4 cm, between 2002 and 2016...
February 14, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29449123/early-impact-of-medicaid-expansion-and-quality-of-breast-cancer-care-in-kentucky
#5
Nicolas Ajkay, Neal Bhutiani, Bin Huang, Quan Chen, Jeffrey D Howard, Thomas C Tucker, Charles R Scoggins, Kelly M McMasters, Hiram C Polk
BACKGROUND: In January 2014, Kentucky expanded Medicaid coverage to include all individuals and families with incomes up to 33% above the federal poverty line. This study evaluated the early impact of Medicaid expansion on some aspects of the quality of breast cancer care in Kentucky. STUDY DESIGN: The Kentucky Cancer Registry was queried for all women aged 20 to 64 years diagnosed with breast cancer between 2011 and 2016. Demographic, tumor, and treatment characteristics were assessed for each year during this interval...
February 10, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29445299/choosing-wisely-after-publication-of-level-i-evidence-in-breast-cancer-radiotherapy
#6
Joshua R Niska, Sameer R Keole, Barbara A Pockaj, Michele Y Halyard, Samir H Patel, Donald W Northfelt, Richard J Gray, Nabil Wasif, Carlos E Vargas, William W Wong
Background: Recent trials in early-stage breast cancer support hypofractionated whole-breast radiotherapy (WBRT) as part of breast-conserving therapy (BCT). Evidence also suggests that radiotherapy (RT) omission may be reasonable for some patients over 70 years. Among radiation-delivery techniques, intensity-modulated RT (IMRT) is more expensive than 3-dimensional conformal RT (3DCRT). Based on this evidence, in 2013, the American Society for Radiation Oncology (ASTRO) recommended hypofractionated schedules for women aged ≥50 years with early-stage breast cancer and avoiding routine use of IMRT for WBRT...
2018: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/29439886/patient-experiences-and-clinician-views-on-the-role-of-radiation-therapy-for-ductal-carcinoma-in-situ
#7
Dean A Shumway, Chandler M McLeod, Monica Morrow, Yun Li, Allison W Kurian, Aaron Sabolch, Ann S Hamilton, Kevin C Ward, Steven J Katz, Sarah T Hawley, Reshma Jagsi
PURPOSE: To evaluate patient experiences with decisions regarding radiation therapy (RT) for ductal carcinoma in situ (DCIS), and to assess clinician views on the role of RT for DCIS with favorable features in the present era. METHODS AND MATERIALS: A sample of women with newly diagnosed breast cancer from the population-based Georgia and Los Angeles County Surveillance, Epidemiology, and End Results (SEER) registries were sent surveys approximately 2 months after undergoing breast-conserving surgery (BCS), with a 70% response rate...
January 9, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29439691/what-matters-most-protocol-for-a-randomized-controlled-trial-of-breast-cancer-surgery-encounter-decision-aids-across-socioeconomic-strata
#8
Marie-Anne Durand, Renata West Yen, A James O'Malley, Mary C Politi, Shubhada Dhage, Kari Rosenkranz, Katie Weichman, Julie Margenthaler, Anna N A Tosteson, Eloise Crayton, Sherrill Jackson, Ann Bradley, Robert J Volk, Karen Sepucha, Elissa Ozanne, Sanja Percac-Lima, Julia Song, Jocelyn Acosta, Nageen Mir, Glyn Elwyn
BACKGROUND: Breast cancer is the most commonly diagnosed malignancy in women. Mastectomy and breast-conserving surgery (BCS) have equivalent survival for early stage breast cancer. However, each surgery has different benefits and harms that women may value differently. Women of lower socioeconomic status (SES) diagnosed with early stage breast cancer are more likely to experience poorer doctor-patient communication, lower satisfaction with surgery and decision-making, and higher decision regret compared to women of higher SES...
February 13, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29435855/the-clinical-impact-of-molecular-breast-imaging-in-women-with-proven-invasive-breast-cancer-scheduled-for-breast-conserving-surgery
#9
Angela Collarino, Renato A Valdés Olmos, Lotta G A J van Berkel, Peter A Neijenhuis, Lidy M H Wijers, Frederik Smit, Lioe-Fee de Geus-Oei, Lenka M Pereira Arias-Bouda
PURPOSE: To investigate the clinical utility of molecular breast imaging (MBI) in patients with proven invasive breast cancer scheduled for breast-conserving surgery (BCS). METHODS: Following approval by the institutional review board and written informed consent, records of patients with newly diagnosed breast cancer scheduled for BCS who had undergone MBI for local staging in the period from March 2012 till December 2014 were retrospectively reviewed. RESULTS: A total of 287 women (aged 30-88 years) were evaluated...
February 13, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29434871/mechanisms-for-dna-damaging-agent-induced-inactivation-of-erbb2-and-erbb3-via-the-erk-and-p38-signaling-pathways
#10
Chul Min Park, Yuki Kawasaki, Alaa Refaat, Hiroaki Sakurai
Cisplatin (CDDP) and doxorubicin (DOX) are chemotherapeutic drugs that trigger apoptosis by inducing DNA-damage. A previous study using breast cancer cells demonstrated the negative feedback modulation of the epidermal growth factor receptor (EGFR) and receptor tyrosine-protein kinase erbB-2 (ErbB2) via extracellular signal-regulated kinase (ERK)-mediated phosphorylation of conserved Thr-669 and Thr-677 residues, respectively, in the juxtamembrane domain. In addition, CDDP has been identified to cause negative feedback inhibition of activated EGFR in lung cancer cells...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29426355/role-of-postoperative-radiotherapy-in-reducing-ipsilateral-recurrence-in-dcis-an-observational-study-of-1048-cases
#11
Stefanie Corradini, Montserrat Pazos, Stephan Schönecker, Daniel Reitz, Maximilian Niyazi, Ute Ganswindt, Simone Schrodi, Michael Braun, Martin Pölcher, Sven Mahner, Nadia Harbeck, Jutta Engel, Claus Belka
BACKGROUND: The objective of the present study was to evaluate the effectiveness of postoperative radiotherapy after breast conserving surgery (BCS) in DCIS in a large patient population treated in clinical practice. METHODS: Data were provided by the population-based Munich Cancer Registry. Between 1998 and 2014, 1048 female patients with diagnosis of DCIS and treated at two Breast Care Centres were included in this observational study. The effectiveness of postoperative radiotherapy and variables predicting the use of radiotherapy were retrospectively analysed...
February 9, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29412447/surgical-treatment-of-multiple-ipsilateral-breast-cancers
#12
Z E Winters, J R Benson
No abstract text is available yet for this article.
February 7, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29396079/review-of-factors-influencing-women-s-choice-of-mastectomy-versus-breast-conserving-therapy-in-early-stage-breast-cancer-a-systematic-review
#13
REVIEW
Jeffrey Gu, Gary Groot, Catherine Boden, Angela Busch, Lorraine Holtslander, Hyun Lim
We have performed a narrative synthesis. A literature search was conducted between January 2000 and June 2014 in 7 databases. The initial search identified 2717 articles; 319 underwent abstract screening, 67 underwent full-text screening, and 25 final articles were included. This review looked at early stage breast cancer in women only, excluding ductal carcinoma in situ and advanced breast cancer. A conceptual framework was created to organize the central constructs underlying women's choices: clinicopathologic factors, physician factors, and individual factors with subgroups of sociodemographic, geographic, and personal beliefs and preferences...
January 3, 2018: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29394797/-a-case-of-ipsilateral-breast-tumor-recurrence-with-breast-ulcer
#14
Goshi Oda, Tsuyoshi Nakagawa, Mio Fukuda, Toshiyuki Ishiba, Kazunori Kubota, Tomoyuki Fujioka, Iichirou Onishi, Hiroyuki Uetake
The patient was a 61-year-old woman with a history of treatment for breast cancer. She had undergone left breast-conserving surgery and axillary lymph node dissection followed by radiation therapy for left breast cancer when she was 43 years old and later presented to our hospital with a chief complaint of a left breast ulcer with a messy exudate. Core needle biopsy (CNB)from the ulcer showed no malignancy. PET-CT showed low FDG uptake at the left breast and high FDG uptake at a contralateral axillary lymph node...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394713/-a-case-report-of-ipsilateral-nipple-skin-recurrence
#15
Mina Waraya, Keiko Hayashi, Sayuri Oshida, Kouichi Yamamoto, Satoshi Hosoya, Takeyoshi Habiro, Madoka Inukai, Yoshimasa Kosaka, Norihiko Sengoku, Masahiko Watanabe
We report our experience with a patient with breast cancer who showed recurrence in the nipple skin 5 years and 10 months after a breast-preserving surgery. The patient was a woman, and was 65-years old at the time of initial surgery. Breast-preserving surgery and axillary lymph-node dissection were performed for left breast cancer. Invasive ductal carcinoma of the breast(pT3N0M0)was triple-negative, and the patient postoperatively received adjuvant chemotherapy. Left breast pain developed 5 years and 6 months after surgery...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394682/-strut-adjusted-volume-implant-savi-an-interim-report-of-patient-satisfaction-and-outcomes
#16
Daigo Yamamoto, Toshiko Siga, Katsuhiro Yoshikawa, Yu Tsubota, Noriko Sueoka, Tsukuru Chiba, Mariko Ishizuka, Masanori Kon
BACKGROUND: Strut adjusted volume implant(SAVI)was approved by the Food and Drug Administration(FDA)for the treatment of breast cancer in 2006. MATERIAL AND METHODS: The phase II study was conducted to investigate the activity and safety of SAVI in breast cancer patients. Criteria for SAVI treatments were N0, T<2 cm, and age≥40. After patients underwent breast-conserving surgery, they received SAVI twice a day×5 days(34 Gy). The primary endpoint are feasibility and safety...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394644/-clinical-efficacy-of-paclitaxel-plus-bevacizumab-combination-therapy-for-bone-marrow-carcinomatosis-arising-from-breast-cancer-a-case-report
#17
Ichiro Nakayama
We report a case of a 42-year-old woman with bone marrow carcinomatosis in the course of metastatic breast cancer who responded well to paclitaxel plus bevacizumab(PTX plus Bev)combination therapy. Four years after initial breast conserving surgery, she was admitted to our hospital with back pain and general malaise and was diagnosed as multiple bone metastases with bone marrow carcinomatosis originating from previous breast cancer(ER+/HER2-). While administering denosumab, we initiated systemic chemotherapy with PTX plus Bev...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394563/-four-cases-of-occult-breast-cancer-treated-with-breast-conserving-therapy-after-neoadjuvant-chemotherapy
#18
Tetsutaro Miyoshi, Masayuki Shiobara, Kazuo Wakatsuki, Syuka Arai, Kosuke Suda, Kotaro Miyazawa, Toshiaki Aida, Yoshihisa Takahashi, Shigeru Yoshioka
We report 4 patients with occult breast cancer(OBC)who underwent breast conserving therapy(BCT)after neoadjuvant chemotherapy(NAC). All patients complained of axillary tumor and were diagnosed by core needle biopsy. Pathological examination of the axillary lymph nodes proved that 3 cases were adenocarcinomas and 1 case was squamous cell carcinoma, but imaging studies could not depict any primary lesions in the breast and other organs. Since distant metastasis was not observed, BCT with axillary lymph node dissection(ALND)was performed after NAC...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29391900/network-analysis-revealed-aurora-kinase-dysregulation-in-five-gynecological-types-of-cancer
#19
Shikha Suman, Ashutosh Mishra
Gene markers are crucial for cancer prognosis and treatment. Previous studies have placed greater emphasis on individual diagnostic genes, thereby ignoring systemic-level attributes across diseases. Female-specific cells namely, breast, endometrium, cervical, ovarian and vulvar cells are highly susceptible to cancer. To date, a limited number of molecular studies have been performed that evaluate common biological processes across gynecological types of cancer. Differentially expressed genes in breast, cervical, endometrial, vulvar and ovarian cancer were utilized to construct protein-protein interaction networks, and to identify a common module across the five cancer types...
January 2018: Oncology Letters
https://www.readbyqxmd.com/read/29388015/refined-estimates-of-local-recurrence-risks-by-dcis-score-adjusting-for-clinicopathological-features-a-combined-analysis-of-ecog-acrin-e5194-and-ontario-dcis-cohort-studies
#20
E Rakovitch, R Gray, F L Baehner, R Sutradhar, M Crager, S Gu, S Nofech-Mozes, S S Badve, W Hanna, L L Hughes, W C Wood, N E Davidson, L Paszat, S Shak, J A Sparano, L J Solin
PURPOSE: Better tools are needed to estimate local recurrence (LR) risk after breast-conserving surgery (BCS) for DCIS. The DCIS score (DS) was validated as a predictor of LR in E5194 and Ontario DCIS cohort (ODC) after BCS. We combined data from E5194 and ODC adjusting for clinicopathological factors to provide refined estimates of the 10-year risk of LR after treatment by BCS alone. METHODS: Data from E5194 and ODC were combined. Patients with positive margins or multifocality were excluded...
January 31, 2018: Breast Cancer Research and Treatment
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