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Breast conservation treatment

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https://www.readbyqxmd.com/read/29674010/one-step-intraoperative-radiotherapy-optimizes-conservative-treatment-of-breast-cancer-with-advantages-in-quality-of-life-and-work-resumption
#1
Luca Sorrentino, Susanna Fissi, Ilaria Meaglia, Daniela Bossi, Ottavia Caserini, Serena Mazzucchelli, Marta Truffi, Sara Albasini, Paola Tabarelli, Marco Liotta, Giovanni B Ivaldi, Fabio Corsi
BACKGROUND: Intraoperative radiotherapy (IORT) could be not-inferior to external beam radiotherapy (EBRT) in selected patients, but toxicities, self-perception of body image, quality of life, and resumption of work or daily activities have been poorly explored. The aim of the present study was to compare these outcomes between EBRT, IORT full-dose (IORT-f) and IORT boost (IORT-b). METHODS: 443 consecutive patients, candidates for breast-conserving surgery, were included: EBRT was performed in 220 patients (49...
April 16, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29673111/comparison-of-epidemiological-features-clinicopathological-features-and-treatments-between-premenopausal-and-postmenopausal-female-breast-cancer-patients-in-western-china-a-retrospective-multicenter-study-of-15-389-female-patients
#2
REVIEW
Fan Feng, Yuxian Wei, Ke Zheng, Yujing Li, Lu Zhang, Tielin Wang, Yanli Zhang, Hongyuan Li, Guosheng Ren, Fan Li
Premenopausal and postmenopausal breast cancers are considered different types. Thus, this study aimed to explore differences in risk factors, epidemiological features, clinicopathological features, and treatment modes of premenopausal breast cancer compared to postmenopausal patients in western China. This was a hospital-based, retrospective, multicenter epidemiological study of patients with breast cancer. Using the Western China Clinical Cooperation Group database, we obtained the records of 15,389 female breast cancers between January 2010 and April 2017...
April 19, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29663173/current-status-of-neoadjuvant-endocrine-therapy-in-early-stage-breast-cancer
#3
REVIEW
Tomás Reinert, Rodrigo Gonçalves, Matthew J Ellis
Neoadjuvant endocrine therapy (NET) with Ki67-based response monitoring is a practical, cost-effective approach to the management of clinical stage II and III estrogen receptor-positive (ER+) breast cancer. In addition to marked improvements in rates of breast conservation, the identification of extreme responders on the basis of the preoperative endocrine prognostic index (PEPI) provides a rationale to avoid chemotherapy on the basis of highly favorable prognosis in some patients. Finally, samples accrued from patients treated with neoadjuvant therapy are providing valuable insights into the molecular basis for intrinsic resistance to endocrine therapy and promise a more rational basis and precise approach to the systemic treatment of ER+ breast cancer...
April 16, 2018: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/29662528/oncoplastic-surgery-for-the-conservative-treatment-of-breast-cancer-in-per%C3%A3%C2%BA-s-national-cancer-institute
#4
Gonzalo Javier Ziegler Rodriguez, Marcelo Diaz Chavez, Gabriela Guadalupe Calderon Valencia, Jose Manuel Cotrina Concha, Milko Raphael Garces Castre, Raul Mantilla
Background: Oncoplastic surgery for breast cancer (OPS) has been a surgical trend for the past 25 years. In 2012, OPS has been introduced as the standard treatment for a selected group of patients at the National Cancer Institute of Peru (INEN). The aim of this study is to describe our findings. Methods: This is a retrospective and descriptive study that identified demographics, tumour-pathologic features and includes patients solely treated since diagnosis until late follow-up at INEN...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29656223/delay-of-adjuvant-radiotherapy-due-to-postoperative-complications-after-oncoplastic-breast-conserving-surgery
#5
Nadine S Hillberg, Marleen A J Meesters-Caberg, Jop Beugels, Bjorn Winkens, Yvonne L J Vissers, Tom J M van Mulken
BACKGROUND: In the past a mastectomy was the first approach of treating breast cancer. Oncoplastic techniques combined with breast conserving surgery (BCS) and radiotherapy has become an alternative to mastectomy in patients with non-metastasized breast cancer. The aim of this study was to analyse the amount and types of complications occurring after oncoplastic BCS before and after adjuvant radiotherapy and the delay of adjuvant therapy due to the complications. METHOD: A retrospective study based on all patients who received immediate oncoplastic BCS by a plastic surgeon at two medical hospitals in The Netherlands between 2013 and 2015...
April 12, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29628978/basic-findings-regarding-breast-cancer-in-korea-in-2015-data-from-a-breast-cancer-registry
#6
REVIEW
Sang Yull Kang, Yoo Seok Kim, Zisun Kim, Hyun-Yul Kim, Se Kyung Lee, Kyu-Won Jung, Hyun Jo Youn
The Korean Breast Cancer Society (KBCS) has established a nationwide breast cancer database using an online registration program in 1996. The present study aimed to analyze the basic findings and trends of breast cancer in Korea in 2015 using the data provided by the Korea Central Cancer Registry and the KBCS. In 2015, a total of 22,550 patients were newly diagnosed with breast cancer, of which 3,331 were carcinoma in situ cases and 19,219 were invasive cancer cases. The incidence rate of breast cancer in Korea has steadily increased since the nationwide database was established, and the crude rate and age-standardized rate including that of carcinoma in situ , were 88...
March 2018: Journal of Breast Cancer
https://www.readbyqxmd.com/read/29622126/role-of-mr-imaging-in-neoadjuvant-therapy-monitoring
#7
REVIEW
Huong T Le-Petross, Bora Lim
Neoadjuvant chemotherapy (NAC) has become an important treatment approach for stage II/III breast cancers to downsize tumor and enable breast-conserving surgery for patients that may otherwise undergo mastectomy. MR imaging has the potential to identify early response or disease progression, enabling potential modification to NAC regimens. Detection of size and morphologic changes is better appreciated with MR imaging than other modalities and is different between molecular subtypes of breast cancer. The combination of DCE-MR imaging and DWI provides the highest sensitivity and specificity...
May 2018: Magnetic Resonance Imaging Clinics of North America
https://www.readbyqxmd.com/read/29616659/introduction-of-a-hybrid-treatment-delivery-system-used-for-quality-assurance-in-multi-catheter-interstitial-brachytherapy
#8
Karoline Kallis, Stephan Kreppner, Michael Lotter, Vratislav Strnad, Rainer Fietkau, Christoph Bert
Multi-catheter interstitial brachytherapy (iBT) is a treatment option for breast cancer patients after breast conserving surgery. Typically, only a few additional quality interventions after the first irradiation have been introduced to ensure the planned treatment delivery. Therefore, the purpose of this study is to show the possibilities of an electromagnetic tracking (EMT) system integrated into the afterloader for quality assurance (QA) in high-dose rate (HDR) iBT of patients with breast cancer. 
 The hybrid afterloader system equipped with an electromagnetic sensor was used for all phantom and patient measurements...
April 4, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29616366/de-escalation-of-breast-radiotherapy-after-conserving-surgery-in-low-risk-early-breast-cancer-patients
#9
REVIEW
Pierfrancesco Franco, Giuseppe Carlo Iorio, Sara Bartoncini, Mario Airoldi, Corrado De Sanctis, Isabella Castellano, Umberto Ricardi
The reduction in the burden related to treatment is becoming more and more important in modern oncology. Radiation therapy is a mainstay option in the postoperative setting for early breast cancer patients after breast-conserving surgery. Nowadays, different options are available to de-escalate radiotherapy in this scenario such as the use of hypofractionated whole-breast radiation, the selective delivery of the boost dose to the lumpectomy cavity, the introduction of accelerated partial breast irradiation and the omission of treatment in appropriately selected patients with low-risk features...
April 3, 2018: Medical Oncology
https://www.readbyqxmd.com/read/29615841/the-incidence-of-postoperative-radiotherapy-induced-acute-dermatitis-in-breast-cancer-and-its-influencing-factors-for-chinese-women
#10
Jingxian Ding, Yonghong Guo, Qingge Li, Jun Chen, Pinghua Hu, Qiuming Liu, Yali Cao, Jiong Wu
Purpose: To investigate the incidence of skin acute reaction and its influencing factors in postoperative breast cancer radiotherapy patients. Methods: One hundred and seventy three cases of breast cancer patients treated with postoperative radiotherapy were consecutively enrolled from June 1, 2016 to July 31, 2017 in our breast cancer center. Irradiation technology includes conformal intensity-modulated radiotherapy and a conventional two-dimensional one with conventional fraction...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29606978/my-burning-issues-in-the-neoadjuvant-treatment-for-breast-cancer
#11
REVIEW
Elisabeth S Bergen, Rupert Bartsch
A combination of anthracyclines and taxanes remains the standard of care for neoadjuvant chemotherapy (NACT) resulting in increased breast conservation rate (BCR) and decreased recurrence rate [1]. Whether pathological complete response (pCR) could be an appropriate surrogate parameter for long-term survival is still a matter of debate. In patients with triple-negative breast cancer (TNBC) and HER2-positive breast cancer (BC), a six to nine times higher risk for relapse has been reported if no pCR was achieved [2, 3]...
2018: Memo
https://www.readbyqxmd.com/read/29605247/breast-reconstruction-after-breast-conservation-therapy-for-breast-cancer
#12
Filip E F Thiessen, Wiebren A A Tjalma, Thierry Tondu
Conservative breast surgery followed by irradiation, often referred to as Breast conserving therapy (BCT), has replaced modified radical mastectomy for the treatment of early stage invasive breast cancer and ductal carcinoma in situ (DCIS). About 10% to 40% of the patients treated with BCT have poor cosmetic outcome results. Small tumours in large breasts can be successfully treated by lumpectomy and radiotherapy, with good cosmetic outcome. However when the tumour breast ratio is higher, the cosmetic outcome can be very disappointing...
March 27, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29595718/breast-cancer-following-augmentation-mammaplasty-a-case-control-study
#13
Michael Sosin, Chaitan Devulapalli, Charles Fehring, Edward R Hammond, Shawna C Willey, Eleni A Tousimis, Scott L Spear, Maurice Y Nahabedian, Elizabeth D Feldman
BACKGROUND: The purpose of this study was to determine whether augmentation mammaplasty, implant type, and implant location affect breast cancer detection, stage, and treatment. METHODS: An institutional case-control study was performed of patients with prior breast augmentation undergoing breast cancer treatment from 2000 to 2013. Controls were propensity matched and randomized, and data were retrospectively reviewed. RESULTS: Forty-eight cases and 302 controls were analyzed...
April 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29594217/treatment-constraints-for-single-dose-external-beam-preoperative-partial-breast-irradiation-in-early-stage-breast-cancer
#14
Ramona K Charaghvandi, Sua Yoo, Bram van Asselen, Anna Rodrigues, Desirée H J G van den Bongard, Janet K Horton
Background: Following breast-conserving surgery and post-operative 3D-conformal accelerated partial breast irradiation (APBI), suboptimal cosmetic results have been reported. Preoperative radiation delivery to the intact tumor enables better target visualization and treatment volume reduction. Single dose preoperative APBI has the potential to improve toxicity profiles, reduce treatment burden and enable in vivo exploration of breast cancer radiogenomics. Purpose: Develop practical guidelines for single dose external beam preoperative APBI...
October 2017: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29594203/association-between-cumulative-radiation-dose-adverse-skin-reactions-and-changes-in-surface-hemoglobin-among-women-undergoing-breast-conserving-therapy
#15
Michael S Chin, Leah Siegel-Reamer, Gordon A FitzGerald, Allison Wyman, Nikole M Connor, Yuan-Chyuan Lo, Shirin Sioshansi, Janaki Moni, Maria Giulia Cicchetti, Janice F Lalikos, Thomas J FitzGerald
Introduction: Radiation therapy is crucial to effective cancer treatment. Modern treatment strategies have reduced possible skin injury, but few clinical studies have addressed the dose relationship between radiation exposure and skin reaction . This prospective clinical study analyzes skin oxygenation/perfusion in patients undergoing fractionated breast conserving therapy via hyperspectral imaging (HSI). Methods: Forty-three women undergoing breast conserving therapy were enrolled in this study...
June 2017: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29593668/simulation-study-of-cdna-dataset-to-investigate-possible-association-of-differentially-expressed-genes-of-human-thp1-monocytic-cells-in-cancer-progression-affected-by-bacterial-shiga-toxins
#16
Syed A Muhammad, Jinlei Guo, Thanh M Nguyen, Xiaogang Wu, Baogang Bai, X Frank Yang, Jake Y Chen
Shiga toxin (Stxs) is a family of structurally and functionally related bacterial cytotoxins produced by Shigella dysenteriae serotype 1 and shigatoxigenic group of Escherichia coli that cause shigellosis and hemorrhagic colitis, respectively. Until recently, it has been thought that Stxs only inhibits the protein synthesis and induces expression to a limited number of genes in host cells, but recent data showed that Stxs can trigger several signaling pathways in mammalian cells and activate cell cycle and apoptosis...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29580733/the-administration-of-adjuvant-chemo-immuno-therapy-in-the-post-acosog-z0011-era-a-population-based-study
#17
Ingrid G M Poodt, Marjolijn L Rots, Guusje Vugts, Thijs van Dalen, Anne Kuijer, Birgit E P J Vriens, Grard A P Nieuwenhuijzen, Robert-Jan Schipper
PURPOSE: The ACOSOG-Z0011-study has resulted in a trend to a more conservative treatment of the axilla for selected sentinel-node-positive patients. However, axillary nodal involvement has always been an important factor for tumor staging and tailoring adjuvant chemotherapy plans. This study evaluates the impact of omitting completion axillary lymph node dissection (cALND) on the administration of adjuvant chemo (-immuno)therapy in Dutch clinical T1-2N0M0 (cT1-2N0M0) sentinel-node-positive breast cancer patients...
March 14, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29579155/a-polymorphism-in-the-lysyl-oxidase-propeptide-domain-accelerates-carcinogen-induced-cancer
#18
Ana de la Cueva, Michael Emmerling, Sarah L Lim, Shi Yang, Philip C Trackman, Gail E Sonenshein, Kathrin H Kirsch
The propeptide (LOX-PP) domain of the lysyl oxidase proenzyme (Pro-LOX) was shown to inhibit the transformed phenotype of breast, lung and pancreatic cells in culture and the formation of Her2/neu-driven breast cancer in a xenograft model. A single nucleotide polymorphism (SNP, rs1800449) positioned in a highly conserved region of LOX-PP results in an Arg158Gln substitution (humans). This ArgGln substitution profoundly impaired the ability of LOX-PP to inhibit the invasive phenotype and xenograft tumor formation...
March 22, 2018: Carcinogenesis
https://www.readbyqxmd.com/read/29579107/correction-prime-incision-a-minimally-invasive-approach-to-breast-cancer-surgical-treatment-a-2-cohort-retrospective-comparison-with-conventional-breast-conserving-surgery
#19
Silvio Eduardo Bromberg, Patricia Rodrigues Alves de Figueiredo Moraes, Felipe Ades
[This corrects the article DOI: 10.1371/journal.pone.0191056.].
2018: PloS One
https://www.readbyqxmd.com/read/29576576/successful-conservative-treatment-of-jaw-osteonecrosis-caused-by-denosumab-in-patients-with-multiple-bone-metastasis
#20
Noritaka Ohga, Jun Sato, Takuya Asaka, Masahiro Morimoto, Yutaka Yamazaki, Yoshimasa Kitagawa
We report a case of osteonecrosis of the jaw (ONJ) associated with denosumab therapy in a 62-year-old female patient being treated for bone metastases from breast cancer. Upon initial presentation at the Department of Oral Medicine, Hokkaido University Hospital, the patient's mandibular molar teeth were extracted because of severe periodontal disease. Two months later, epithelialization of the sockets was observed and treatment with anti-resorptive drugs was started for bone metastases. One year after tooth extraction, bone exposure in the right lower first molar region was observed, and stage 2 medication-related ONJ (MRONJ) was diagnosed...
2018: Journal of Oral Science
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