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https://www.readbyqxmd.com/read/28422090/surgical-treatment-in-paget-s-disease-with-invasive-ductal-carcinoma-an-observational-study-based-on-seer
#1
Qi Wu, Xiaojun Ding, Juanjuan Li, Si Sun, Shan Zhu, Juan Wu, Qian Liu, Feng Yao, Shengrong Sun
The aim is to analyse the clinical presentation, treatment and outcomes in patients with Paget's disease with invasive ductal carcinoma (PD-IDC), with special emphasis on the role of surgical treatment. Using data obtained by the Surveillance, Epidemiology, and End Results (SEER) program from 2010-2013, we investigated the differences in characteristics, overall survival (OS), and breast cancer-specific mortality (BCSM) between patients with PD-IDC and those with invasive ductal carcinoma (IDC). Compared with IDC group, patients with PD-IDC had a better prognosis and lower mortality in adjusted analyses...
April 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28416489/nrf2-induction-supporting-breast-cancer-cell-survival-is-enabled-by-oxidative-stress-induced-dpp3-keap1-interaction
#2
Kevin Lu, Allen L Alcivar, Jianglin Ma, Tzeh K Foo, Susan Zwyea, Amar Mahdi, Yanying Huo, Thomas W Kensler, Michael L Gatza, Bing Xia
NRF2 is a transcription factor serving as a master regulator of the expression of many genes involved in cellular responses to oxidative and other stresses. In the absence of stress, NRF2 is constantly synthesized but maintained at low levels as it is targeted by KEAP1 for ubiquitination and proteasome-mediated degradation. NRF2 binds KEAP1 mainly through a conserved "ETGE" motif that has also been found in several other proteins, such as DPP3, which has been shown to bind KEAP1 and enhance NRF2 function upon overexpression...
April 17, 2017: Cancer Research
https://www.readbyqxmd.com/read/28412323/single-cpg-site-methylation-controls-estrogen-receptor-gene-transcription-and-correlates-with-hormone-therapy-resistance
#3
Kouki Tsuboi, Takamasa Nagatomo, Tatsuyuki Gohno, Toru Higuchi, Shunta Sasaki, Natsu Fujiki, Masafumi Kurosumi, Hiroyuki Takei, Yuri Yamaguchi, Toshifumi Niwa, Shin-Ichi Hayashi
Hormone therapy is the most effective treatment for patients with estrogen receptor α-positive breast cancers. However, although resistance occurs during treatment in some cases and often reflects changed estrogen receptor α status, the relationship between changes in estrogen receptor α expression and resistance to therapy are poorly understood. In this study, we identified a mechanism for altered estrogen receptor α expression during disease progression and acquired hormone therapy resistance in aromatase inhibitor-resistant breast cancer cell lines...
April 12, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28408621/endocrine-therapy-initiation-and-medical-oncologist-utilization-among-women-diagnosed-with-ductal-carcinoma-in-situ
#4
Chelsea Anderson, Anne Marie Meyer, Stephanie B Wheeler, Lei Zhou, Katherine E Reeder-Hayes, Hazel B Nichols
BACKGROUND: Though randomized clinical trials have demonstrated a reduction in second breast events with endocrine therapy among women with ductal carcinoma in situ (DCIS), use of these therapies remains highly variable. The purpose of this study was to evaluate patient and treatment-related factors associated with endocrine therapy initiation and medical oncology specialty utilization after DCIS. MATERIALS AND METHODS: We identified women with a DCIS diagnosis during 2006-2010 in the North Carolina Central Cancer Registry with linked public and private insurance claims in the University of North Carolina Integrated Cancer Information Surveillance System data resource...
April 13, 2017: Oncologist
https://www.readbyqxmd.com/read/28407247/using-the-21-gene-assay-from-core-needle-biopsies-to-choose-neoadjuvant-therapy-for-breast-cancer-a-multicenter-trial
#5
Harry D Bear, Wen Wan, André Robidoux, Peter Rubin, Steven Limentani, Richard L White, James Granfortuna, Judith O Hopkins, Dwight Oldham, Angel Rodriguez, Amy P Sing
OBJECTIVE: We hypothesized that the Oncotype Dx(®) 21-gene Recurrence Score (RS) could guide neoadjuvant systemic therapy (NST) to facilitate breast conserving surgery (BCS) for hormone receptor positive (HR+) breast cancers. METHODS: This study enrolled patients with HR+, HER2-negative, invasive breast cancers not suitable for BCS (size ≥ 2 cm). Core needle biopsy blocks were tested. For tumors with RS < 11, patients received hormonal therapy (NHT); patients with RS > 25 tumors received chemotherapy (NCT); patients with RS 11-25 were randomized to NHT or NCT...
April 13, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28405101/the-feasibility-study-of-a-hybrid-coplanar-arc-technique-versus-hybrid-intensity-modulated-radiotherapy-in-treatment-of-early-stage-left-sided-breast-cancer-with-simultaneous-integrated-boost
#6
Yuan-Gui Chen, An-Chuan Li, Wen-Yao Li, Miao-Yun Huang, Xiao-Bo Li, Ming-Qiu Chen, Mutian Zhang, Ben-Hua Xu
This study demonstrated the feasibility and advantages of a hybrid, volumetric arc therapy technique that used two 90° coplanar arcs and two three-dimensional conformal tangential beams in the simultaneous-integrated boost radiotherapy of left-sided breast cancer after breast-conserving surgery. A total of nine patients with stage I, left-sided breast cancer who underwent breast-conserving surgery were selected for this retrospective study. For each patient, a hybrid arc plan was generated and then compared with two hybrid intensity-modulated radiotherapy plans...
January 2017: Journal of Medical Physics
https://www.readbyqxmd.com/read/28403971/-performances-of-breast-magnetic-resonance-imaging-in-the-context-of-neoadjuvant-chemotherapy-for-breast-cancer-to-predict-pathological-complete-response
#7
C Brisson, C Diguisto, A Vildé, G Body, F Arbion, J Leveque, L Ouldamer
PURPOSE: The objective of this work was to estimate the reliability of MRI after neoadjuvant chemotherapy (NAC) for breast cancer to detect a residual tumour by comparing the tumoral size measured by MRI with the histological size. We also estimated the concordance of diagnosis of complete pathological response between histological examination and MRI. MATERIALS AND METHODS: We included all the patients who received a neoadjuvant chemotherapy for breast cancer in the university hospital of Tours from January, 2008 to December 31st, 2012 and in the comprehensive cancer centre of Rennes from January, 2008 till May 31st 201...
February 2017: J Gynecol Obstet Hum Reprod
https://www.readbyqxmd.com/read/28402085/decision-aids-for-people-facing-health-treatment-or-screening-decisions
#8
REVIEW
Dawn Stacey, France Légaré, Krystina Lewis, Michael J Barry, Carol L Bennett, Karen B Eden, Margaret Holmes-Rovner, Hilary Llewellyn-Thomas, Anne Lyddiatt, Richard Thomson, Lyndal Trevena
BACKGROUND: Decision aids are interventions that support patients by making their decisions explicit, providing information about options and associated benefits/harms, and helping clarify congruence between decisions and personal values. OBJECTIVES: To assess the effects of decision aids in people facing treatment or screening decisions. SEARCH METHODS: Updated search (2012 to April 2015) in CENTRAL; MEDLINE; Embase; PsycINFO; and grey literature; includes CINAHL to September 2008...
April 12, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28401542/quality-of-life-after-mastectomy-with-or-without-immediate-breast-reconstruction
#9
J Dauplat, F Kwiatkowski, P Rouanet, E Delay, K Clough, J L Verhaeghe, I Raoust, G Houvenaeghel, P Lemasurier, E Thivat, C Pomel
BACKGROUND: Mastectomy with immediate breast reconstruction (IBR) is a surgical strategy in breast cancer when breast-conserving surgery is not an option. There is a lack of evidence showing an advantage of mastectomy plus IBR over mastectomy alone on health-related quality of life (QoL). METHODS: A large prospective multicentre survey, STIC-RMI (support of innovative and expensive techniques - immediate breast reconstruction), was undertaken to study the changes in QoL in patients treated by mastectomy with or without IBR...
April 12, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28400348/to-clip-or-not-to-clip-the-breast-tumour-bed-a-retrospective-look-at-the-geographical-miss-index-and-normal-tissue-index-of-110-breast-cancer-patients
#10
Florian Ebner, Nikolaus deGregorio, Andreas Rempen, Peter Mohr, Amelie de Gregorio, Achim Wöckel, Wolfgang Janni, Gerlo Witucki
OBJECTIVE: Planning of breast radiation for patients with breast conserving surgery often relies on clinical markers like scars. Lately surgical clips have been used to identify the tumour location. The purpose of this study is to evaluate the geographical miss index (GMI) and the normal tissue index (NTI) for the electron boost in breast cancer treatment plans with and without surgical clips. MATERIAL AND METHODS: A retrospective descriptive study of 110 consecutive post surgical patients with breast-conserving treatment in early breast cancer comparing the clinical treatment field with the radiological (clipped) field and respectively calculating the GMI/NTI for the electron boost...
February 7, 2017: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/28396099/management-of-isolated-locoregional-recurrences%C3%A2-in-breast-cancer-a-review-of-local%C3%A2-and-systemic-modalities
#11
REVIEW
Tabassum Wadasadawala, Rohit Vadgaonkar, Jyoti Bajpai
Locoregional recurrence (LRR) after adequate treatment of primary breast cancer poses a therapeutic challenge. Advances in the management of breast cancer have led to significant improvements in survival. With this advantage, it is observed that the incidence of LRR has relatively decreased. Systemic involvement should be ruled out in patients presenting with locoregionally recurrent disease, as isolated LRR requires a treatment with curative intent. Salvage mastectomy following ipsilateral breast tumor recurrence is a time-tested treatment option and widely accepted...
March 21, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28393991/-quality-of-life-in-chilean-breast-cancer-survivors
#12
M Elisa Irarrázaval, Pascale Kleinman, Fernando Silva R, Loreto Fernández González, Camilo Torres, Marcela Fritis, Carolina Barriga, Herman Waintrub
BACKGROUND: Quality of Life (QOL) assessment may evaluate the impact of diseases and their treatment on the overall well-being of patients. AIM: To assess QOL in Chilean breast cancer survivors. PATIENTS AND METHODS: Ninety one female breast cancer patients aged 60 ± 10 years, who finished their oncologic treatment at least a year prior to the assessment, who were disease free and in medical follow-up were included in the study. They completed the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 core questionnaire and the breast cancer module QLQ-BR23...
December 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/28391587/ageism-and-surgical-treatment-of-breast-cancer-in-italian-hospitals
#13
Mirko Di Rosa, Carlos Chiatti, Joseph M Rimland, Marina Capasso, Valerio M Scandali, Emilia Prospero, Andrea Corsonello, Fabrizia Lattanzio
AIM: To determine if age is a factor influencing the type of breast cancer surgery (radical versus conservative) in Italy and to investigate the regional differences in breast cancer surgery clinical practice. METHODS: Retrospective study is based on national hospital discharge records. The study draws on routinely collected data from hospital discharge records in Italy in 2010. The following exclusion criteria were applied: day hospital stays, patients younger than 17 years, males, patients without an ICD-9CM code indicating breast cancer and breast surgery, and repeated hospital admission of the same patient...
April 8, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28384565/impact-of-hormonal-status-on-outcome-of-ductal-carcinoma-in-situ-treated-with-breast-conserving-surgery-plus-radiotherapy-long-term-experience-from-two-large-institutional-series
#14
Icro Meattini, Calogero Saieva, Paolo Bastiani, Francesca Martella, Giulio Francolini, Monica Lo Russo, Lisa Paoletti, Morena Doria, Isacco Desideri, Francesca Terziani, Carla De Luca Cardillo, Benedetta Bendinelli, Cinzia Ciabatti, Cristina Muntoni, Galliano Tinacci, Jacopo Nori, Herd Smith, Beniamino Brancato, Lorenzo Galli, Luis Jose Sanchez, Donato Casella, Marco Bernini, Lorenzo Orzalesi, Giulio Alberto Carta, Simonetta Bianchi, Francesca Rossi, Lorenzo Livi
BACKGROUND: Ductal carcinoma in situ (DCIS) is a heterogeneous disease, for which the best adjuvant treatment is still uncertain. Many attempts of risk-groups stratification have been made over time, developing prognostic scores to predict risk of local recurrence (LR) on the basis of features such as age, final surgical margins (FSM) status, grade, and tumor size. The aim of our analysis was to evaluate the patterns of recurrence from a two large-institutional retrospective series. PATIENTS AND METHODS: We collected data on 457 patients treated with BCS and adjuvant RT between 1990 and 2012...
April 3, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28382097/oncologic-outcomes-after-immediate-breast-reconstruction-following-total-mastectomy-in-patients-with-breast-cancer-a-matched-case-control-study
#15
Jai Min Ryu, Hyun-June Paik, Sungmin Park, Ha Woo Yi, Seok Jin Nam, Seok Won Kim, Se Kyung Lee, Jonghan Yu, Soo Youn Bae, Jeong Eon Lee
PURPOSE: The use of immediate breast reconstruction (IBR) following total mastectomy (TM) has increased markedly in patients with breast cancer. As the indications for IBR have been broadened and more breast-conserving surgery-eligible patients are undergoing IBR, comparing the oncologic safety between TM only and IBR following TM becomes more difficult. This study aimed to analyze the oncologic outcomes between TM only and IBR following TM via a matched case-control methodology. METHODS: A retrospective review was conducted to identify all patients who underwent TM between 2008 and 2014...
March 2017: Journal of Breast Cancer
https://www.readbyqxmd.com/read/28377213/risk-factors-and-state-of-the-art-indications-for-boost-irradiation-in-invasive-breast-carcinoma
#16
REVIEW
Alfredo Polo, Csaba Polgár, Jean-Michel Hannoun-Levi, Jose-Luis Guinot, Cristina Gutierrez, Razvan Galalae, Erik van Limbergen, Vratislav Strnad
PURPOSE: The aim of the study was to give recommendations on patient selection criteria for the administration of boost doses after whole-breast irradiation (WBI) in invasive breast cancer based on available clinical evidence complemented by expert opinion. METHODS AND MATERIALS: A systematic search of the PubMed database was conducted to identify factors associated with increased risk for local failure that can define risk groups, and to provide evidence for an adequate guidance to the use of the boost as a function of the risk of local recurrence in breast-conserving therapy...
April 1, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28376574/conservation-surgery-and-radiation-therapy-in-early-breast-cancer-an-update
#17
Ellen Tailby, John Boyages Am
BACKGROUND: Multiple randomised trials and meta-analyses have supported the use of conservative surgery (CS) and radiation therapy (RT) for the treatment of early-stage breast cancer. Following lumpectomy, RT has been shown to decrease the chance of local recurrence and improve overall survival when compared with lumpectomy alone. OBJECTIVE: This update outlines the rationale and outcomes for CS and RT, whether a subgroup exists in which RT may be safely omitted, the process of RT, common side effects and their management, and the latest techniques in the field...
2017: Australian Family Physician
https://www.readbyqxmd.com/read/28376188/regional-nodal-irradiation-after-breast-conserving-surgery-for-early-her2-positive-breast-cancer-results-of-a-subanalysis-from-the-altto-trial
#18
Isabelle Gingras, Eileen Holmes, Evandro De Azambuja, David H A Nguyen, Miguel Izquierdo, Jo Anne Zujewski, Moshe Inbar, Bjorn Naume, Gianluca Tomasello, Julie R Gralow, Antonio C Wolff, Lyndsay Harris, Michael Gnant, Alvaro Moreno-Aspitia, Martine J Piccart, Hatem A Azim
Background: Two randomized trials recently demonstrated that regional nodal irradiation (RNI) could reduce the risk of recurrence in early breast cancer; however, these trials were conducted in the pretrastuzumab era. Whether these results are applicable to human epidermal growth factor receptor 2 (HER2)-positive breast cancer patients treated with anti-HER2-targeted therapy is unknown. Methods: This retrospective analysis was performed on patients with node-positive breast cancer who were enrolled in the Adjuvant Lapatinib and/or Trastuzumab Treatment Optimization phase III adjuvant trial and subjected to BCS...
August 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28364525/complications-after-cosmetic-surgery-tourism
#19
Holger J Klein, Dario Simic, Nina Fuchs, Riccardo Schweizer, Tarun Mehra, Pietro Giovanoli, Jan A Plock
Background: Cosmetic surgery tourism characterizes a phenomenon of people traveling abroad for aesthetic surgery treatment. Problems arise when patients return with complications or need of follow-up care. Objectives: To investigate the complications of cosmetic surgery tourism treated at our hospital as well as to analyze arising costs for the health system. Methods: Between 2010 and 2014, we retrospectively included all patients presenting with complications arising from cosmetic surgery abroad...
April 1, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/28362229/late-chronotypes-are-associated-with-neoadjuvant-chemotherapy-induced-nausea-and-vomiting-in-women-with-breast-cancer
#20
Kwang-Min Lee, Doo-Young Jung, Heesung Hwang, Won-Hyoung Kim, Joo-Young Lee, Tae-Yong Kim, Seock-Ah Im, Kyung-Hun Lee, David Spiegel, Bong-Jin Hahm
Neoadjuvant chemotherapy, that is, the administration of chemotherapy before surgery, has been commonly used for locally advanced breast cancer to improve the surgical outcomes and increase the opportunity for breast-conserving therapy. Women with breast cancer often receive an anthracycline-based regimen as the neoadjuvant chemotherapy, which is associated with a high risk of emesis. Despite the development of novel antiemetics, chemotherapy-induced nausea and vomiting (CINV) has been commonly reported as a major adverse effect, affecting the quality of life of the patients...
2017: Chronobiology International
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