Richard J Barohn, Byron Gajewski, Mamatha Pasnoor, Alexandra Brown, Laura L Herbelin, Kim S Kimminau, Dinesh Pal Mudaranthakam, Omar Jawdat, Mazen M Dimachkie, Stanley Iyadurai, Amro Stino, John Kissel, Robert Pascuzzi, Thomas Brannagan, Matthew Wicklund, Aiesha Ahmed, David Walk, Gordon Smith, Dianna Quan, Darryl Heitzman, Alejandro Tobon, Shafeeq Ladha, Gil Wolfe, Michael Pulley, Ghazala Hayat, Yuebing Li, Pariwat Thaisetthawatkul, Richard Lewis, Suur Biliciler, Khema Sharma, Kian Salajegheh, Jaya Trivedi, William Mallonee, Ted Burns, Mark Jacoby, Vera Bril, Tuan Vu, Sindhu Ramchandren, Mark Bazant, Sara Austin, Chafic Karam, Yessar Hussain, Christen Kutz, Paul Twydell, Stephen Scelsa, Hani Kushlaf, James Wymer, Michael Hehir, Noah Kolb, Jeffrey Ralph, Alexandru Barboi, Navin Verma, Moiz Ahmed, Anza Memon, David Saperstein, Jau-Shin Lou, Andrea Swenson, Tiyonnoh Cash
IMPORTANCE: Cryptogenic sensory polyneuropathy (CSPN) is a common generalized slowly progressive neuropathy, second in prevalence only to diabetic neuropathy. Most patients with CSPN have significant pain. Many medications have been tried for pain reduction in CSPN, including antiepileptics, antidepressants, and sodium channel blockers. There are no comparative studies that identify the most effective medication for pain reduction in CSPN. OBJECTIVE: To determine which medication (pregabalin, duloxetine, nortriptyline, or mexiletine) is most effective for reducing neuropathic pain and best tolerated in patients with CSPN...
January 1, 2021: JAMA Neurology