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Alpha intrusions in sleep

Sujith Vijayan, Elizabeth B Klerman, Gail K Adler, Nancy J Kopell
Alpha-delta sleep is the abnormal intrusion of alpha activity (8- to 13-Hz oscillations) into the delta activity (1- to 4-Hz oscillations) that defines slow-wave sleep. Alpha-delta sleep is especially prevalent in fibromyalgia patients, and there is evidence suggesting that the irregularities in the sleep of these patients may cause the muscle and tissue pain that characterizes the disorder. We constructed a biophysically realistic mathematical model of alpha-delta sleep. Imaging studies in fibromyalgia patients suggesting altered levels of activity in the thalamus motivated a thalamic model as the source of alpha activity...
September 2015: Journal of Neurophysiology
Valdas Noreika, Andrés Canales-Johnson, Justin Koh, Mae Taylor, Irving Massey, Tristan A Bekinschtein
The transition from a relaxed to a drowsy state of mind is often accompanied by hypnagogic experiences: most commonly, perceptual imagery, but also linguistic intrusions, i.e., the sudden emergence of unpredictable anomalies in the stream of inner speech. This study has sought to describe the contents of such intrusions, to verify their association with the progression of sleep onset, and to investigate the electroencephalographic processes associated with linguistic intrusions as opposed to more common hypnagogic perceptual imagery...
2015: Frontiers in Psychology
Tomás Maresca, Elvira Covini, Andrea Márquez López Mato
We present a description of the Central Sensitivity Syndrome (CSS) and some of its main components such as Multiple Chemical Sensitivity Syndrome, Chronic Fatigue Syndrome and Fibromyalgia. We review the changes in pain perception, describing the physiology and pathophysiology of the painful experience from the medulla horn to the CNS. We explain the theory of central sensitization as the basis to the syndrome. We refer to the differences between fibromyalgia and depressive disorders, is spite of their frequent presentation in comorbidity...
September 2013: Vertex: Revista Argentina de Psiquiatriá
Julie Youssef, Kanwaljit Singh, Noelle Huntington, Ronald Becker, Sanjeev V Kothare
OBJECTIVE: Although children with autism spectrum disorders experience a range of sleep disturbances, exact mechanisms are not well-characterized. We investigated the association of serum-ferritin to sleep fragmentation and periodic limb movements of sleep using polysomnography in children with autism spectrum disorders. METHODS: We conducted a retrospective chart review of children with autism spectrum disorders followed from 1990 to 2010. Inclusion criteria were availability of polysomnography data and ferritin levels within 12 months of each other...
October 2013: Pediatric Neurology
Leslie H Sherlin, Noel C Larson, Rebecca M Sherlin
Neurofeedback may be useful for improving sports performance but few studies have examined this potential. Here we present data of five development players from a major league baseball team. The aims were to evaluate the feasibility of conducting sessions within a professional organization, assess changes in quantitative electroencephalograph (QEEG), NeuroPerformance Profile™, and report qualitative self-report data before and after brain training. The EEG was recorded with 19 electrodes for 20 min of baseline conditions and approximately 21 min of a continuous performance test...
March 2013: Applied Psychophysiology and Biofeedback
Hajime Minakuchi, Chiyomi Sakaguchi, Emilio S Hara, Kenji Maekawa, Yoshizo Matsuka, Glenn T Clark, Takuo Kuboki
PURPOSE: Small, self-contained electromyographic (EMG) detector/analyzer (D/A) devices have become available for the detection of jaw muscle activity events above threshold. These devices claim to be less intrusive to the subjects sleep so it is less prone to induce disturbed sleep. The objective of this study was to evaluate for night-to-night variability and examine for a systematic alteration on the first night in EMG levels. METHODS: Ten asymptomatic healthy volunteers (mean age, 26...
December 2012: Sleep & Breathing, Schlaf & Atmung
Nattapong Jaimchariyatam, Carlos L Rodriguez, Kumar Budur
Objective. Major depressive disorder is associated with sleep disturbances. An electroencephalographic pattern of alpha wave intrusion in delta wave sleep (alpha-delta sleep) is observed in some subjects with major depressive disorder. The treatment-resistant symptoms in major depressive disorder, nonrestorative sleep and fatigue, are associated with alpha-delta sleep. The objective of this study is to identify the prevalence and clinical correlates of alpha-delta sleep in major depressive disorder.Design. Retrospective studySetting...
July 2011: Innovations in Clinical Neuroscience
Raffaele Manni, Michele Terzaghi, Pietro-Luca Ratti, Alessandra Repetto, Roberta Zangaglia, Claudio Pacchetti
REM sleep behaviour disorder (RBD) is a REM sleep-related parasomnia which may be considered a "dissociated state of wakefulness and sleep", given that conflicting elements of REM sleep (dreaming) and of wakefulness (sustained muscle tone and movements) coexist during the episodes, leading to motor and behavioural manifestations reminiscent of an enacted dream. RBD has been reported in association with α-synucleinopathies: around a third of patients with Parkinson's disease (PD) have full-blown RBD. Recent data indicate that PD patients with RBD are more prone to hallucinations than PD patients without this parasomnia...
December 2011: Consciousness and Cognition
Harvey Moldofsky, Neil H Inhaber, Diane R Guinta, Sarah B Alvarez-Horine
OBJECTIVE: To determine the effects of sodium oxybate (SXB) on sleep physiology and sleep/wake-related symptoms in patients with fibromyalgia syndrome (FM). METHODS: Of 304 patients with FM (American College of Rheumatology tender point criteria) in the screened study population, 209 underwent polysomnography, 195 were randomized, and 151 completed this 8-week, double-blind, placebo-controlled study of SXB 4.5 g and 6 g/night. We evaluated changes in objective sleep measures and subjective symptoms, including daytime sleepiness [Epworth Sleepiness Scale (ESS)], fatigue visual analog scale (FVAS), sleep [Jenkins Scale for Sleep (JSS)], and daytime functioning [Functional Outcome of Sleep Questionnaire (FOSQ), SF-36 Vitality domain, and Fibromyalgia Impact Questionnaire (FIQ) general and morning tiredness]...
October 2010: Journal of Rheumatology
L Leventhal, B Freundlich, J Lewis, K Gillen, J Henry, D Dinges
Chronic fatigue and nonrestorative sleep are prominent features of fibromyalgia (FM). It has been reported that these patients have alpha-wave intrusion during nonrapid eye movement (NREM) sleep (stages 2,3,4). Although alpha-NREM sleep has been noted in patients with other rheumatic disorders, a paucity of controlled data limits the interpretation of these reports. To determine the specificity of alphaNREM sleep, FM patients were compared with pain-free controls and with patients with generalized musculoskeletal pain without evidence of FM...
April 1995: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
Youn Sung Kim, Hyun Jae Baek, Jung Soo Kim, Haet Bit Lee, Jong Min Choi, Kwang Suk Park
A helmet-based system that was able to monitor the drowsiness of a soldier was developed. The helmet system monitored the electrocardiogram, electrooculogram and electroencephalogram (alpha waves) without constraints. Six dry electrodes were mounted at five locations on the helmet: both temporal sides, forehead region and upper and lower jaw strips. The electrodes were connected to an amplifier that transferred signals to a laptop computer via Bluetooth wireless communication. The system was validated by comparing the signal quality with conventional recording methods...
February 2009: European Journal of Applied Physiology
O Meeus, C Blaivie, P Van de Heyning
OBJECTIVES: To validate the Dutch and the French version of the Tinnitus Questionnaire and characterise the subscales. The original Tinnitus Questionnaire has already proven to be a usable measurement tool to discriminate complaining from non-complaining tinnitus patients and it provides differentiation into 5 dimensions. METHODS: The English version of the TQ was used. The Dutch and the French version were obtained by the process of translation and back-translation...
2007: B-ENT
Elisa Magosso, Mauro Ursino, Federica Provini, Pasquale Montagna
This study investigates the relationship between changes in the electroencephalogram (EEG) and slow eye movements (SEMs) in the electro-oculogram (EOG) at the wake-sleep transition. Analysis of EEG and EOG is performed by the discrete wavelet transform and utilizes energy functions built within the multiresolution framework. In particular, SEMs are detected automatically by a computerized system, previously developed and validated; core of the system is a function of EOG energies at different scales of decomposition, which defines SEMs in rigorous energetic terms...
2007: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
James K Boehnlein, J David Kinzie
This article reviews the neurobiologic rationale for and presents clinical guidance concerning the use of medications that reduce central nervous system noradrenergic activity in the treatment of intrusive symptoms of posttraumatic stress disorder. The authors reviewed neurobiological studies, nonclinical studies using animal models, clinical case reports, open-label drug studies, and blinded, placebo-controlled drug studies. This review of the basic science and clinical literature, and the authors' clinical experience with culturally and demographically diverse populations, indicate that clonidine and prazosin can play a useful role in treating sleep disturbance and hyperarousal in posttraumatic stress disorder, with minimal adverse effects and low financial cost...
March 2007: Journal of Psychiatric Practice
Elke Van Hoof, Pascale De Becker, Charles Lapp, Raymond Cluydts, Kenny De Meirleir
BACKGROUND: Patients with chronic fatigue syndrome (CFS) present a disordered sleep pattern and frequently undergo polysomnography to exclude a primary sleep disorder. Such studies have shown reduced sleep efficiency, a reduction of deep sleep, prolonged sleep initiation, and alpha-wave intrusion during deep sleep. Deregulation of the 2-5A synthetase/RNase L antiviral pathway and a potential acquired channelopathy are also found in a subset of CFS patients and could lead to sleep disturbances...
February 2007: American Journal of the Medical Sciences
Michael Friedman, Jorge R Miranda-Massari, Michael J Gonzalez
The use of sustained release tri-iodothyronine (SR-T3) in clinical practice, has gained popularity in the complementary and alternative medical community in the treatment of chronic fatigue with a protocol (WT3) pioneered by Dr. Denis Wilson. The WT3 protocol involves the use of SR-T3 taken orally by the patient every 12 hours according to a cyclic dose schedule determined by patient response. The patient is then weaned once a body temperature of 98.6 degrees F has been maintained for 3 consecutive weeks. The symptoms associated with this protocol have been given the name Wilson's Temperature Syndrome (WTS)...
March 2006: Puerto Rico Health Sciences Journal
Lisa J Meltzer, Deirdre E Logan, Jodi A Mindell
This study examined sleep patterns in female adolescents with chronic musculoskeletal pain. Twenty-six participants with chronic musculoskeletal pain completed questionnaires during their clinic visit, and three 24-Hour Sleep Patterns Interviews during the following 2 weeks. Compared to normative data (Acebo & Carskadon, 2002), adolescents with chronic pain reported similar total sleep time (TST) and bedtimes. However, study participants reported significantly longer sleep onset latency, more night wakings, a later morning wake time, and more symptoms of daytime sleepiness...
2005: Behavioral Sleep Medicine
Marta Novak, Kenneth Mah, Miklos Zs Molnar, Csaba Ambrus, Gabor Csepanyi, Agnes Kovacs, Eszter Vamos, Monika Zambo, Rezso Zoller, Istvan Mucsi, Gerald M Devins
OBJECTIVES: The objectives of this study were to compare the factor structure and to assess the reliability of the Hungarian version of the Illness Intrusiveness Rating Scale (IIRS), testing internal validity and employing simultaneous confirmatory factor analysis (SCFA) in two large samples of North American versus Hungarian patients with end-stage renal disease (ESRD). METHODS: Translation was conducted according to current recommendations. Following pilot testing, 365 maintenance haemodialysis patients completed the scale...
January 2005: Journal of Psychosomatic Research
Kimberly A Cote, Catherine E Milner, Stephanie L Osip, Laura B Ray, Karen D Baxter
STUDY OBJECTIVES: Experimental sleep fragmentation involves inducing arousals by administering intrusive auditory stimuli throughout the night. It is intended to model the frequent and periodic disruption experienced in common sleep disorders. Sleep fragmentation leads to daytime sleepiness, although evidence of performance impairment has been inconsistent. The purpose of this study was to investigate brain physiology associated with this level of sleep disruption. Specifically, quantitative analysis of electroencephalography was carried out, and auditory event-related potentials were recorded during daytime performance assessment following sleep fragmentation in good sleepers...
September 2003: Sleep
Martin B Scharf, Margaret Baumann, David V Berkowitz
OBJECTIVE: Fibromyalgia (FM) is associated with the sleep phenomenon of alpha intrusion, and with low growth hormone secretion. Sodium oxybate has been shown to increase both slow-wave sleep and growth hormone levels. This double blind, randomized, placebo controlled crossover trial was conducted to evaluate the effects of sodium oxybate on the subjective symptoms of pain, fatigue, and sleep quality and the objective polysomnographic (PSG) sleep variables of alpha intrusion, slow-wave (stage 3/4) sleep, and sleep efficiency in patients with FM...
May 2003: Journal of Rheumatology
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