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https://www.readbyqxmd.com/read/28806519/pluronic-p85-f68-micelles-of-baicalein-could-interfere-with-mitochondria-to-overcome-mrp2-mediated-efflux-and-offer-improved-anti-parkinsonian-activity
#1
Tongkai Chen, Ye Li, Chuwen Li, Xiang Yi, Ruibing Wang, Simon Ming Yuen Lee, Ying Zheng
Overexpression of the drug efflux transporter multidrug resistance-associated protein 2 (MRP2) in the gastrointestinal tract and blood-brain barrier compromises the oral delivery of drugs to the circulation system and brain in the treatment of Parkinson's disease (PD). In this study, we aim to develop small-sized Pluronic P85/F68 micelles loaded with baicalein (B-MCs) to overcome MRP2-mediated efflux and to investigate related mechanism, as well as the anti-Parkinsonian efficacy. Spherical and sustained-release B-MCs have a mean particle size of 40...
August 14, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28806349/dual-phase-99mtc-mibi-imaging-and-the-expressions-of-p-gp-gst-%C3%AF-and-mrp1-in-hyperparathyroidism
#2
Jianjun Xue, Yan Liu, Danrong Yang, Yan Yu, Qianqian Geng, Ting Ji, Lulu Yang, Qi Wang, Yuanbo Wang, Xueni Lu, Aimin Yang
OBJECTIVE: The aim of this study was to further elucidate the mechanisms of dual-phase technetium-99m methoxyisobutylisonitrile (Tc-MIBI) parathyroid imaging by exploring the association between early uptake results (EUR), delayed uptake results (DUR), and the retention index (RI) in dual-phase Tc-MIBI parathyroid imaging and P glycoprotein (P-gp), multidrug resistance-associated protein 1 (MRP1), and glutathione S-transferase-π (GST-π) expression in hyperparathyroidism (HPT). PATIENTS AND METHODS: Preoperative dual-phase (early and delayed) Tc-MIBI imaging was performed on 74 patients undergoing parathyroidectomy for HPT...
August 11, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28805554/apitherapeutics-and-phage-loaded-nanofibers-as-wound-dressings-with-enhanced-wound-healing-and-antibacterial-activity
#3
Wessam A Sarhan, Hassan Me Azzazy
AIM: Develop green wound dressings which exhibit enhanced wound-healing ability and potent antibacterial effects. METHODS: Honey, polyvinyl alcohol, chitosan nanofibers were electrospun and loaded with bee venom, propolis and/or bacteriophage against the multidrug-resistant Pseudomonas aeruginosa and examined for their antibacterial, wound-healing ability and cytotoxicity. RESULTS: Among different formulations of nanofibers, honey, polyvinyl alcohol, chitosan-bee venom/bacteriophage exhibited the most potent antibacterial activity against all tested bacterial strains (Gram-positive and -negative strains) and achieved nearly complete killing of multidrug-resistant P...
August 14, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28805537/high-prevalence-of-extended-spectrum-%C3%AE-lactamase-producing-enterobacteriaceae-in-wild-fish-from-the-mediterranean-sea-in-algeria
#4
Soumia Brahmi, Abdelaziz Touati, Catherine Dunyach-Remy, Albert Sotto, Alix Pantel, Jean-Philippe Lavigne
AIM: We investigated the prevalence of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae among wild fish from the coast of Bejaia (Algeria) in the Mediterranean Sea. RESULTS: From March 2012 to August 2013, gut and gill samples of wild fish were screened for the presence of ESBL-producing Enterobacteriaceae. Strains were characterized with regard to antibiotic resistance, β-lactamase content, plasmid-mediated quinolone resistance, aminoglycoside resistance genes, and clonality (repetitive sequence-based polymerase chain reaction profiles and multilocus sequence typing)...
August 14, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28805040/hpma-copolymer-drug-conjugates-with-controlled-tumor-specific-drug-release
#5
REVIEW
Petr Chytil, Eva Koziolová, Tomáš Etrych, Karel Ulbrich
Over the past few decades, numerous polymer drug carrier systems are designed and synthesized, and their properties are evaluated. Many of these systems are based on water-soluble polymer carriers of low-molecular-weight drugs and compounds, e.g., cytostatic agents, anti-inflammatory drugs, or multidrug resistance inhibitors, all covalently bound to a carrier by a biodegradable spacer that enables controlled release of the active molecule to achieve the desired pharmacological effect. Among others, the synthetic polymer carriers based on N-(2-hydroxypropyl) methacrylamide (HPMA) copolymers are some of the most promising carriers for this purpose...
August 14, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28804585/detection-of-ctx-m-15-among-uropathogenic-escherichia-coli-isolated-from-five-major-hospitals-in-tripoli-libya
#6
Abdulaziz Zorgani, Asma Almagatef, Najib Sufya, Abdulla Bashein, Abdullatif Tubbal
OBJECTIVES: Multidrug resistance (MDR) and emergence of extended-spectrum β-lactamases (ESBLs) among uropathogenic Escherichia coli have been reported worldwide, but there was no information on the detection of blaCTX-M-15 in major teaching hospitals in Libya. The aim of the study was to investigate the occurrence of CTX-M-15 β-lactamases producers isolated from five teaching hospitals in Tripoli, Libya. METHODS: A total of 346 urine samples were collected from hospitalized patients in five teaching hospitals with a diagnosis of urinary tract infection (UTI)...
July 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/28803989/mdr65-decreases-toxicity-of-multiple-insecticides-in-drosophila-melanogaster
#7
Haina Sun, Nicolas Buchon, Jeffrey G Scott
ABC transporters are ubiquitous membrane-bound proteins, present in both prokaryotes and eukaryotes. The major function of eukaryotic ABC transporters is to mediate the efflux of a variety of substrates (including xenobiotics) out of cells. ABC transporters have been widely investigated in humans, particularly for their involvement in multidrug resistance (MDR). Considerably less is known about their roles in transport and/or excretion in insects. ABC transporters are only known to function as exporters in insects...
August 10, 2017: Insect Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28803838/current-epidemiology-of-resistance-among-gram-negative-bacilli-in-pediatric-patients-in-turkey
#8
Kubra Aykac, Yasemin Ozsurekci, Sevgen Tanir Basaranoglu, Mustafa Senol Akin, Ali Bulent Cengiz, Asiye Bicakcigil, Banu Sancak, Ates Kara, Mehmet Ceyhan
BACKGROUND: The increasing incidence of infections caused by drug-resistant Gram-negative organisms has led to a reemergence in worldwide. This study attempted to investigate the changes in resistance of Gram-negative bacteria to different classes of antibiotics and treatment options in invasive infections. METHODS: We performed this study retrospectively between January 2012 and January 2017 in our tertiary care university hospital. A total of 302 patients with Gram-negative bacterial bacteremia and meningitis were defined...
August 10, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28803661/daily-bathing-strategies-and-cross-transmission-of-multidrug-resistant-organisms-impact-of-chlorhexidine-impregnated-wipes-in-a-multidrug-resistant-gram-negative-bacteria-endemic-intensive-care-unit
#9
Jesus Ruiz, Paula Ramirez, Esther Villarreal, Monica Gordon, Inmaculada Saez, Alfonso Rodríguez, María Jesús Castañeda, Álvaro Castellanos-Ortega
BACKGROUND: Health-care associated infections are a major cause of morbidity and mortality in critical care units. The aim of this study is to evaluate the effectiveness of chlorhexidine gluconate (CHG)-impregnated wipes in the daily bathing of patients in an intensive care unit (ICU) to prevent cross-transmission and colonization by multidrug-resistant organisms (MDROs) METHODS: Prospective cohort study with an intervention of 11 months. The intervention consisted of using CHG-impregnated wipes for the daily bathing of patients on mechanical ventilation or colonized by MDROs...
August 10, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28803496/management-of-multidrug-resistant-pseudomonas-aeruginosa-in-the-intensive-care-unit-state-of-the-art
#10
Alberto Enrico Maraolo, Marco Cascella, Silvia Corcione, Arturo Cuomo, Salvatore Nappa, Guglielmo Borgia, Francesco Giuseppe De Rosa, Ivan Gentile
Pseudomonas aeruginosa (PA) is one of the most important causes of healthcare-related infections among Gram-negative bacteria. The best therapeutic approach is controversial, especially for multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains as well as in the setting of most severe patients, such as in the intensive care unit (ICU). Areas covered: This article addresses several points. First, the main microbiological aspects of PA, focusing on its wide array of resistance mechanisms. Second, risk factors and the worse outcome linked to MDR-PA infection...
August 14, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/28802406/real-time-pcr-followed-by-high-resolution-melting-curve-analysis-a-rapid-and-pragmatic-approach-for-screening-of-multidrug-resistant-extrapulmonary-tuberculosis
#11
Kusum Sharma, Megha Sharma, Shreya Singh, Manish Modi, Aman Sharma, Pallab Ray, Subhash Varma
INTRODUCTION: Multidrug resistance (MDR) in extrapulmonary tuberculosis (EPTB) is a diagnostic challenge in an endemic country like India. Timely detection of MDR-TB can contribute to a better patient outcome. OBJECTIVE: To perform real-time PCR (qPCR) using rpoB, mpb64 and IS6110 gene on a variety of EPTB samples and to compare the performance of different gene targets. All qPCR positive samples were subjected to high resolution melt-curve analysis (HRM analysis) for rpoB and katG gene to evaluate its potential for MDR screening among different sample types...
September 2017: Tuberculosis
https://www.readbyqxmd.com/read/28802182/inflammatory-markers-as-risk-factors-for-infection-with-multidrug-resistant-microbes-in-diabetic-foot-subjects
#12
Saba Noor, Abhijit Girish Borse, Maaz Ozair, Alok Raghav, Iqbal Parwez, Jamal Ahmad
BACKGROUND: Diabetic foot ulcers (DFUs), a dreadful microvascular complication of diabetes is responsible for substantial increase in morbidity and mortality. Infection, not a cause, but a consequence in DFUs that accounts for minor or major limb loss. The current study aimed to evaluate the microbial etiology of infected diabetic foot ulcers in northern tertiary care hospital, assessment of risk factors and role of inflammatory markers involved in colonization of multidrug-resistant organisms (MDROs) and their impact on the outcome...
May 3, 2017: Foot
https://www.readbyqxmd.com/read/28801276/transferability-of-antimicrobial-resistance-from-multidrug-resistant-escherichia-coli-isolated-from-cattle-in-the-united-states-to-escherichia-coli-and-salmonella-newport-recipients
#13
T L Poole, T R Callaway, K N Norman, H M Scott, G H Loneragan, S A Ison, R C Beier, D M Harhay, B Norby, D J Nisbet
OBJECTIVE: To evaluate conjugative transfer of cephalosporin resistance among (n=100) strains of multi-drug resistant Escherichia coli (MDRE) to Salmonella Newport and E. coli DH5α recipients. METHODS: Phenotypic and genotypic profiles were determined for MDRE, Salmonella Newport (trSN) and E. coli DH5α (trDH) transconjugants. RESULTS: Twenty-seven percent (n=26) and 28% (n=27) of (n=95) MDR E. coli donor isolates transferred resistance to trSN and trDH recipient isolates, respectively...
August 8, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28800411/antimicrobial-resistance-and-resistance-genes-in-salmonella-strains-isolated-from-broiler-chickens-along-the-slaughtering-process-in-china
#14
Yuanting Zhu, Haimei Lai, Likou Zou, Sheng Yin, Chengtao Wang, Xinfeng Han, Xiaolong Xia, Kaidi Hu, Li He, Kang Zhou, Shujuan Chen, Xiaolin Ao, Shuliang Liu
A total of 189 Salmonella isolates were recovered from 627 samples which were collected from cecal contents of broilers, chicken carcasses, chicken meat after cutting step and frozen broiler chicken products along the slaughtering process at a slaughterhouse in Sichuan province of China. The Salmonella isolates were subjected to antimicrobial susceptibility testing to 10 categories of antimicrobial agents using the Kirby-Bauer disk diffusion method. Those antibiotics-resistant isolates were further investigated for the occurrence of resistance genes, the presence of class 1 integron as well as the associated gene cassettes, and the mutations within the gyrA and parC genes...
August 1, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28799786/p1220-ctxm-a-pkp048-related-incfiik-plasmid-carrying-bla-ctx-m-14-and-qnrb4
#15
Defu Zhang, Zhe Yin, Yuzong Zhao, Jiao Feng, Xiaoyuan Jiang, Zhe Zhan, Weili Wu, Weijun Chen, Jinglin Wang, Jianrong Li, Dongsheng Zhou
AIM: This study aimed to characterize plasmid-mediated antimicrobial resistance in clinical Klebsiella pneumoniae 1220 carrying bla CTX-M-14 and qnrB4. MATERIALS & METHODS: Plasmid p1220-CTXM was transformed from the 1220 isolate into Escherichia coli through conjugal transfer and then fully sequenced. Antimicrobial susceptibility was determined by VITEK. RESULTS: p1220-CTXM was an IncFIIK plasmid genetically closely related to pKP048 and carried resistance markers including bla CTX-M-14, bla DHA-1, qnrB4, sul1 and qacEΔ1, all of which were harbored in a 35...
August 11, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28799523/bactericidal-activity-of-the-ti-13nb-13zr-alloy-against-different-species-of-bacteria-related-with-implant-infection
#16
John-Jairo Aguilera-Correa, Ana Conde, Maria-Angeles Arenas, Juan-Jose de-Damborenea, Miguel Marin, Antonio L Doadrio, Jaime Esteban
The Ti-6Al-4V alloy is one of the most commonly used in orthopedic surgery. Despite its advantages, there is an increasing need to use new titanium alloys with no toxic elements and improved biomechanical properties, such as Ti-13Nb-13Zr. Prosthetic joint infections (PJI) are mainly caused by Gram-positive bacteria; however, Gram-negative bacteria are a growing problem due to associated multidrug resistance. In this study, the bacterial adherence and viability on the Ti-13Nb-13Zr alloy have been compared to that of the Ti-6Al-4V alloy using 16 collection and clinical strains of bacterial species related to PJI: Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, and Pseudomonas aeruginosa...
August 11, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28799332/attaching-the-nora-efflux-pump-inhibitor-inf55-to-methylene-blue-enhances-antimicrobial-photodynamic-inactivation-of-methicillin-resistant-staphylococcus-aureus-in-vitro-and-in-vivo
#17
Ardeshir Rineh, Naveen K Dolla, Anthony R Ball, Maria Magana, John B Bremner, Michael R Hamblin, George P Tegos, Michael J Kelso
Antimicrobial photodynamic inactivation (aPDI) uses photosensitizers (PSs) and harmless visible light to generate reactive oxygen species (ROS) and kill microbes. Multidrug efflux systems can moderate the phototoxic effects of PSs by expelling the compounds from cells. We hypothesized that increasing intracellular concentrations of PSs by inhibiting efflux with a covalently attached efflux pump inhibitor (EPI) would enhance bacterial cell phototoxicity and reduce exposure of neighbouring host cells to damaging ROS...
August 11, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/28799224/genomic-insights-into-the-pathogenicity-and-environmental-adaptability-of-enterococcus-hirae-r17-isolated-from-pork-offered-for-retail-sale
#18
Zixin Peng, Menghan Li, Wei Wang, Hongtao Liu, Séamus Fanning, Yujie Hu, Jianzhong Zhang, Fengqin Li
Genetic information about Enterococcus hirae is limited, a feature that has compromised our understanding of these clinically challenging bacteria. In this study, comparative analysis was performed of E. hirae R17, a daptomycin-resistant strain isolated from pork purchased from a retail market in Beijing, China, and three other enterococcal genomes (Enterococcus faecium DO, Enterococcus faecalis V583, and E. hirae ATCC(™) 9790). Some 1,412 genes were identified that represented the core genome together with an additional 139 genes that were specific to E...
August 10, 2017: MicrobiologyOpen
https://www.readbyqxmd.com/read/28799127/evaluation-of-the-antimicrobial-activity-of-a-blend-of-monoglycerides-against-escherichia-coli-and-enterococci-with-multiple-drug-resistance
#19
Immacolata Anacarso, Andrea Quartieri, Riccardo De Leo, Andrea Pulvirenti
Bacterial antibiotic resistance is a natural phenomenon, seriously affecting the treatment of infections. The biggest danger is that current antibiotics are not able to eradicate the resistant strains. In recent years, alternative antibacterial substances are being sought, which can help in these cases. Fatty acids and monoglycerides are known among the natural substances for their antimicrobial properties and, important detail, bacteria do not develop resistance to them. In this work, we studied the antimicrobial effects of a monoglyceride blend against some multi-resistant Enterococci and Escherichia coli strains...
August 10, 2017: Archives of Microbiology
https://www.readbyqxmd.com/read/28798931/prevalence-and-molecular-characterization-of-second-line-drugs-resistance-among-multidrug-resistant-mycobacterium-tuberculosis-isolates-in-southwest-of-china
#20
Y Hu, L Xu, Y L He, Y Pang, N Lu, J Liu, J Shen, D M Zhu, X Feng, Y W Wang, C Yang
This study aimed to investigate the prevalence of multidrug-resistant tuberculosis (MDR-TB) isolates resistant to the second-line antituberculosis drugs (SLDs) and its association with resistant-related gene mutations in Mycobacterium tuberculosis (M.tb) isolates from Southwest of China. There were 81 isolates resistant to at least one of the SLDs among 156 MDR-TB isolates (81/156, 51.9%). The rates of general resistance to each of the drugs were as follows: OFX (66/156, 42.3%), KAN (26/156, 16.7%), CAP (13/156, 8...
2017: BioMed Research International
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