keyword
MENU ▼
Read by QxMD icon Read
search

Post finasteride syndrome

keyword
https://www.readbyqxmd.com/read/28408350/neuroactive-steroid-levels-and-psychiatric-and-andrological-features-in-post-finasteride-patients
#1
MULTICENTER STUDY
Roberto Cosimo Melcangi, Daniele Santi, Roberto Spezzano, Maria Grimoldi, Tommaso Tabacchi, Maria Letizia Fusco, Silvia Diviccaro, Silvia Giatti, Giuseppe Carrà, Donatella Caruso, Manuela Simoni, Guido Cavaletti
Recent reports show that, in patients treated with finasteride for male pattern hair loss, persistent side effects including sexual side effects, depression, anxiety and cognitive complaints may occur. We here explored the psychiatric and andrological features of patients affected by post-finasteride syndrome (PFS) and verified whether the cerebrospinal fluid (CSF) and plasma levels of neuroactive steroids (i.e., important regulators of nervous function) are modified. We found that eight out of sixteen PFS male patients considered suffered from a DSM-IV major depressive disorder (MDD)...
July 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28222425/post-finasteride-adverse-effects-in-male-androgenic-alopecia-a-case-report-of-vitiligo
#2
Ion G Motofei, David L Rowland, Simona R Georgescu, Mircea Tampa, Stana Paunica, Vlad D Constantin, Cristian Balalau, Mirela Manea, Bogdan C Baleanu, Ioanel Sinescu
Finasteride has proved to be relatively safe and effective in the therapeutic management of male androgenic alopecia. However, literature data report several endocrine imbalances inducing various adverse effects, which often persist after treatment cessation in the form of post-finasteride syndrome. Here we present the case of a 52-year-old man receiving finasteride (1 mg/day) who developed an uncommon adverse effect represented by generalized vitiligo 2 months after finasteride discontinuation. Associated adverse effects encountered were represented by mild sexual dysfunction (as determined by the International Index of Erectile Function, IIEF) and moderate depressive symptoms (according to DSM-V criteria), all of these manifestations aggregating within/as a possible post-finasteride syndrome...
2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28161756/safety-profile-of-finasteride-distribution-of-adverse-effects-according-to-structural-and-informational-dichotomies-of-the-mind-brain
#3
REVIEW
Ion G Motofei, David L Rowland, Mirela Manea, Simona R Georgescu, Ioana Păunică, Ioanel Sinescu
Finasteride is currently used extensively for male androgenic alopecia and benign prostatic hyperplasia; however, some adverse effects are severe and even persistent after treatment cessation, the so-called 'post-finasteride syndrome'. The following most severe adverse effects-sexual dysfunction and depression-often occur together and may potentiate one other, a fact that could explain (at least in part) the magnitude and persistence of finasteride adverse effects. This paper presents the pharmacological action of finasteride and the corresponding adverse effects, the biological base explaining the occurrence, persistence and distribution of these adverse effects, and a possible therapeutic solution for post-finasteride syndrome...
June 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/28024997/androgen-receptor-ar-gene-cag-n-and-ggn-n-length-polymorphisms-and-symptoms-in-young-males-with-long-lasting-adverse-effects-after-finasteride-use-against-androgenic-alopecia
#4
Sabina Cauci, Giovanni Chiriacò, Erika Cecchin, Giuseppe Toffoli, Serena Xodo, Giuseppe Stinco, Carlo Trombetta
INTRODUCTION: Long-term adverse symptoms of men who used oral finasteride against androgenic alopecia have been recently described as post-finasteride syndrome (PFS). AIM: To determine whether (CAG)n-rs4045402 and (GGN)n-rs3138869 polymorphisms in the androgen receptor (AR) gene are implicated in PFS. METHODS: AR polymorphisms were studied according to PFS symptoms in 66 white participants (31.8% Italian, 28.8% American, and 39.4% other). MAIN OUTCOME MEASURES: Symptoms were investigated by an ad hoc 100-item questionnaire and the Arizona Sexual Experience Scale and Aging Male Symptom Scale (AMS)...
March 2017: Sexual Medicine
https://www.readbyqxmd.com/read/27672412/adverse-effects-and-safety-of-5-alpha-reductase-inhibitors-finasteride-dutasteride-a-systematic-review
#5
REVIEW
Jason M Hirshburg, Petra A Kelsey, Chelsea A Therrien, A Carlo Gavino, Jason S Reichenberg
Finasteride and dutasteride, both 5-alpha reductase inhibitors, are considered first-line treatment for androgenetic hair loss in men and used increasingly in women. In each case, patients are expected to take the medications indefinitely despite the lack of research regarding long-term adverse effects. Concerns regarding the adverse effects of these medications has led the United States National Institutes of Health to add a link for post-finasteride syndrome to its Genetic and Rare Disease Information Center...
July 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/27298504/atypical-post-finasteride-syndrome-a-pharmacological-riddle
#6
Anita K Gupta, Neetu Sharma, Prashant Shukla
Finasteride and dutasteride are commonly used 5-alpha reductase inhibitors. While finasteride is a selective inhibitor of 5-alpha reductase Type II, dutasteride inhibits 5- alpha reductase Type I and II. The United States Food and Drug Administration approved the use of finasteride for benign prostatic hypertrophy (BPH) as well as androgenic alopecia (AGA) while dutasteride is approved only for BPH. Off-label use of dutasteride is not uncommon in AGA as well. Although the postfinasteride syndrome (PFS) is a well-established entity, its symptomatology is quite variable...
May 2016: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/26868914/emotional-consequences-of-finasteride-fool-s-gold
#7
Christine Anne Ganzer, Alan Roy Jacobs
Androgenetic alopecia, the gradual, progressive loss of hair frequently results in psychological despair, in part related to changes in self-image. Current androgenetic alopecia treatments are limited to hair transplantation and medications that inhibit dihydrotestosterone, a potent androgen associated with follicular micronization. Users of finasteride, which prevents dihydrotestosterone production, report serious physical and emotional adverse effects, collectively known as post-finasteride syndrome. Psychiatric illnesses and personality traits, specifically neuroticism influence emotional well-being...
February 11, 2016: American Journal of Men's Health
https://www.readbyqxmd.com/read/26763726/an-observational-retrospective-evaluation-of-79-young-men-with-long-term-adverse-effects-after-use-of-finasteride-against-androgenetic-alopecia
#8
G Chiriacò, S Cauci, G Mazzon, C Trombetta
Concern regarding adverse effects of finasteride is increasing. We aimed to determine the type and frequency of symptoms in men having long-term sexual and non-sexual side effects after finasteride treatment (a condition recently called post-finasteride syndrome, PFS) against androgenetic alopecia (AGA). Subjects were recruited at the Urology Unit of the Trieste University-Hospital, and from a dedicated website. Out of 79 participants, 34% were white Italians, mean age was 33.4 ± 7.60 years, mean duration of finasteride use was 27...
March 2016: Andrology
https://www.readbyqxmd.com/read/26509855/american-association-of-clinical-endocrinologists-american-college-of-endocrinology-and-androgen-excess-and-pcos-society-disease-state-clinical-review-guide-to-the-best-practices-in-the-evaluation-and-treatment-of-polycystic-ovary-syndrome-part-1
#9
Neil F Goodman, Rhoda H Cobin, Walter Futterweit, Jennifer S Glueck, Richard S Legro, Enrico Carmina
Polycystic Ovary Syndrome (PCOS) is recognized as the most common endocrine disorder of reproductive-aged women around the world. This document, produced by the collaboration of the American Association of Clinical Endocrinologists (AACE) and the Androgen Excess and PCOS Society (AES) aims to highlight the most important clinical issues confronting physicians and their patients with PCOS. It is a summary of current best practices in 2015. PCOS has been defined using various criteria, including menstrual irregularity, hyperandrogenism, and polycystic ovary morphology (PCOM)...
November 2015: Endocrine Practice
https://www.readbyqxmd.com/read/24928450/persistent-sexual-emotional-and-cognitive-impairment-post-finasteride-a-survey-of-men-reporting-symptoms
#10
Christine Anne Ganzer, Alan Roy Jacobs, Farin Iqbal
Finasteride is a synthetic 5-α reductase inhibitor, which prevents the conversion of testosterone to dihydrotestosterone and has been used for more than 20 years in the treatment of male pattern hair loss. Randomized, controlled trials have associated finasteride with both reversible and persistent adverse effects. In this pilot study, we sought to characterize sexual and nonsexual adverse effects that men reported experiencing at least 3 months after stopping the medication. Based on previous research on persistent side effects of finasteride, we constructed an Internet survey targeting six domains: physical symptoms, sexual libido, ejaculatory disorders, disorders of the penis and testes, cognitive symptoms, and psychological symptoms and was e-mailed to patients who reported experiencing symptoms of side effects of finasteride...
May 2015: American Journal of Men's Health
https://www.readbyqxmd.com/read/24855036/a-pharmacogenetic-survey-of-androgen-receptor-cag-n-and-ggn-n-polymorphisms-in-patients-experiencing-long-term-side-effects-after-finasteride-discontinuation
#11
Erika Cecchin, Elena De Mattia, Giorgio Mazzon, Sabina Cauci, Carlo Trombetta, Giuseppe Toffoli
Finasteride is a steroid 5-alpha-reductase inhibitor, approved for the treatment of androgenetic alopecia (AGA) and benign prostate hyperplasia. In some patients the treatment is associated with adverse side effects that could become persistent after therapy discontinuation, resulting in the so-called post-finasteride syndrome (PFS). A pharmacogenetic component in the response to finasteride treatment was previously demonstrated. Two polymorphisms (CAG) rs4045402 and (GGN) rs3138869 in the gene encoding for the androgen receptor (AR) have been hypothesized to play a role in finasteride sensitivity...
December 9, 2014: International Journal of Biological Markers
https://www.readbyqxmd.com/read/24632522/development-and-evaluation-of-animal-models-for-sex-steroid-deficient-dry-eye
#12
Smrita Singh, Laxmi Moksha, Namrata Sharma, Jeevan Singh Titiyal, Nirhar Ranjan Biswas, Thirumurthy Velpandian
PURPOSE: The present study was conducted to develop animal models to mimic postmenopausal/androgen deficiency dry eye and to evaluate the expression of sex steroid receptors (NR3A1, NR3A2 and NR3C4) in the ocular tissues of the developed models. METHODS: The study was conducted in healthy Wistar rats of either sex weighing 180-250g. Bilateral ovariectomy was performed in female rats and oral finasteride (dose of 1.16mg/kg/day) challenge was given to both male and female rats...
July 2014: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/17511983/chronic-progesterone-treatment-augments-while-dehydroepiandrosterone-sulphate-prevents-tolerance-to-ethanol-anxiolysis-and-withdrawal-anxiety-in-rats
#13
Ajaykumar N Sharma, Chandrabhan T Chopde, Khemraj Hirani, Dadasaheb M Kokare, Rajesh R Ugale
We have recently shown that the neurosteroid allopregnanolone modulates anxiolytic effect of ethanol. In the present report, we attempted to examine whether neurosteroids progesterone and dehydroepiandrosterone sulphate (DHEAS), which modulate gamma-aminobutyric acid (GABA(A)) receptor function, affects development of tolerance to ethanol anxiolysis and withdrawal anxiety. Rats on ethanol (6% v/v in nutritionally balanced liquid diet) for prolong period (10 days) were injected twice daily either with vehicle, progesterone (a precursor of allopregnanolone, positive GABA(A) receptor modulator), finasteride (5alpha-reductase inhibitor) or DHEAS (negative GABA(A) receptor modulator)...
July 19, 2007: European Journal of Pharmacology
https://www.readbyqxmd.com/read/17428611/sex-differences-in-the-effect-of-finasteride-on-acute-ethanol-withdrawal-severity-in-c57bl-6j-and-dba-2j-mice
#14
COMPARATIVE STUDY
R E Gorin-Meyer, K M Wiren, M A Tanchuck, S L Long, N Yoneyama, D A Finn
The neurosteroid allopregnanolone (ALLO) is a potent positive modulator of GABAA receptors that can modulate ethanol (EtOH) withdrawal. The 5alpha-reductase inhibitor finasteride can block the formation of ALLO and other GABAergic neurosteroids and also reduce certain effects of EtOH. Treatment with finasteride during chronic EtOH exposure decreased EtOH withdrawal severity and blood EtOH concentrations (BECs), suggesting an additional effect of finasteride on EtOH pharmacokinetics. Thus, the purpose of the present study was to determine the effect of finasteride on acute EtOH withdrawal severity, to minimize the effect of finasteride on EtOH metabolism...
May 25, 2007: Neuroscience
https://www.readbyqxmd.com/read/12223963/-hirsutism-and-hypertrichosis-in-adults-investigations-and-treatment
#15
REVIEW
A Bennet
Hypertrichosis, characterized by increased hair growth located in non-androgen-dependent areas, does not justify the monitoring of hormone levels, conversely to hirsutism, with increased hair growth in androgen-dependent areas of the female genitals. Adult hypertrichosis is iatrogenic (minoxidil, ciclosporine, diazoxide or glucocorticosteroids), of metabolic origin (porphyria), nutritional (anorexia) or paraneoplastic (hypertrichosis lanuoginosa). Metabolic or general assessment can help clinical diagnosis...
May 2002: Annales de Dermatologie et de Vénéréologie
1
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"