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https://www.readbyqxmd.com/read/29424663/a-large-scale-mutational-analysis-of-two-component-signaling-systems-of-lonsdalea-quercina-revealed-that-kdpd-kdpe-regulates-bacterial-virulence-against-host-poplar-trees
#1
Ruo-Lan Yang, Chao-Ying Deng, Jin-Wei Wei, Wei He, Ai-Ning Li, Wei Qian
Poplar, which is a dominant species in plant communities distributed in the northern hemisphere, is commonly used as a model plant in forestry studies. Poplar production can be inhibited by infections caused by bacteria, including Lonsdalea quercina subsp. populi, which is a Gram-negative bacterium responsible for bark canker disease. However, the molecular basis of the pathogenesis remains uncharacterized. In this study, we annotated the two-component signal transduction systems (TCSs) encoded by the L. quercina subsp...
February 9, 2018: Molecular Plant-microbe Interactions: MPMI
https://www.readbyqxmd.com/read/29419686/the-clinical-efficacy-of-epalrestat-combined-with-%C3%AE-lipoic-acid-in-diabetic-peripheral-neuropathy-protocol-for-a-systematic-review-and-meta-analysis
#2
Xiaotong Wang, Haixiong Lin, Shuai Xu, Yuanlin Jin, Ren Zhang
BACKGROUND: Diabetic peripheral neuropathy (DPN) is a common long-term complication of diabetes mellitus, affecting patients in the world. Epalrestat combined with α-lipoic acid (ALA) is the most frequent combine therapy used in the DPN researches. We aim to assess the effectiveness and safety of epalrestat combined with ALA in patients with DPN, compare with epalrestat alone. METHODS: We will search Cochrane Library, PubMed, Wanfang Data, China National Knowledge Infrastructure, VIP Chinese Science and Technology Journals Database, and Chinese Biomedical Database from inception until October 31th, 2017...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29410457/sensory-deprivation-in-staphylococcus-aureus
#3
Maite Villanueva, Begoña García, Jaione Valle, Beatriz Rapún, Igor Ruiz de Los Mozos, Cristina Solano, Miguel Martí, José R Penadés, Alejandro Toledo-Arana, Iñigo Lasa
Bacteria use two-component systems (TCSs) to sense and respond to environmental changes. The core genome of the major human pathogen Staphylococcus aureus encodes 16 TCSs, one of which (WalRK) is essential. Here we show that S. aureus can be deprived of its complete sensorial TCS network and still survive under growth arrest conditions similarly to wild-type bacteria. Under replicating conditions, however, the WalRK system is necessary and sufficient to maintain bacterial growth, indicating that sensing through TCSs is mostly dispensable for living under constant environmental conditions...
February 6, 2018: Nature Communications
https://www.readbyqxmd.com/read/29374286/evidence-of-cross-regulation-in-two-closely-related-pyruvate-sensing-systems-in-uropathogenic-escherichia-coli
#4
Bradley D Steiner, Allison R Eberly, Melanie N Hurst, Ellisa W Zhang, Hamilton D Green, Stefan Behr, Kirsten Jung, Maria Hadjifrangiskou
Two-component systems (TCSs) dictate many bacterial responses to environmental change via the activation of a membrane-embedded sensor kinase, which has molecular specificity for a cognate response regulator protein. However, although the majority of TCSs operate through seemingly strict cognate protein-protein interactions, there have been several reports of TCSs that violate this classical model of signal transduction. Our group has recently demonstrated that some of these cross-interacting TCSs function in a manner that imparts a fitness advantage to bacterial pathogens...
January 27, 2018: Journal of Membrane Biology
https://www.readbyqxmd.com/read/29354650/the-logics-of-metabolic-regulation-in-bacteria-challenges-biosensor-based-metabolic-engineering
#5
COMMENT
Matthieu Jules
Synthetic Biology (SB) aims at the rational design and engineering of novel biological functions and systems. By facilitating the engineering of living organisms, SB promises to facilitate the development of many new applications for health, biomanufacturing, and the environment. Over the last decade, SB promoted the construction of libraries of components enabling the fine-tuning of genetic circuits expression and the development of novel genome engineering methodologies for many organisms of interest. SB thus opened new perspectives in the field of metabolic engineering, which was until then mainly limited to (over)producing naturally synthesized metabolic compounds...
December 11, 2017: Microbial Cell
https://www.readbyqxmd.com/read/29339416/exploring-the-almost-unknown-archaeal-two-component-systems
#6
Tino Krell
Two-component systems (TCS) exist in bacteria and archaea. In contrast to bacterial TCSs little information is available on their archaeal counterparts. In this issue Galperin and coworkers present a bioinformatics analysis of TCS genes from archaeal genome sequences. This study identified different aspects in which bacterial and archaeal TCS mediated signaling differ and forms a sound basis for the experimental design of studies to increase our knowledge on this poorly investigated protein family.
January 16, 2018: Journal of Bacteriology
https://www.readbyqxmd.com/read/29299752/backbone-resonance-assignment-of-the-response-regulator-protein-phobnf20d-from-escherichia-coli
#7
Xinhui Kou, Xinghong Liu, Yixiang Liu, Conggang Li, Maili Liu, Ling Jiang
PhoB is a response regulator of the PhoR/PhoB two-component signal transduction system that is involved in the regulation of the phosphate (Pho) regulon of Escherichia coli. PhoB has two domains, receiver domain and effector domain. The receiver domain can be phosphorylated by its cognate histidine kinase PhoR and the phosphorylation induces conformational changes of the full length protein of PhoB that promote the DNA binding and transcription. Three-dimensional crystal structures of PhoB receiver domain (PhoBN) have been solved under apo or BeF3- (a phosphoryl analog) binding forms and it has been found that PhoBN is dimerized in both situations...
January 3, 2018: Biomolecular NMR Assignments
https://www.readbyqxmd.com/read/29290041/oligomeric-states-in-sodium-ion-dependent-regulation-of-cyanobacterial-histidine-kinase-2
#8
Iskander M Ibrahim, Liang Wang, Sujith Puthiyaveetil, Norbert Krauß, Jon Nield, John F Allen
Two-component signal transduction systems (TCSs) consist of sensor histidine kinases and response regulators. TCSs mediate adaptation to environmental changes in bacteria, plants, fungi and protists. Histidine kinase 2 (Hik2) is a sensor histidine kinase found in all known cyanobacteria and as chloroplast sensor kinase in eukaryotic algae and plants. Sodium ions have been shown to inhibit the autophosphorylation activity of Hik2 with precedes phosphoryl transfer to response regulators, but the mechanism of inhibition has not been determined...
December 30, 2017: Protoplasma
https://www.readbyqxmd.com/read/29259937/effects-of-immunocytokine-combined-with-cattle-encephalon-glycoside-and-ignotin-on-ctgf-ho-1-and-nt-3-in-patients-with-type-2-diabetic-peripheral-neuropathy
#9
Jianguo Sun, Hui Zheng, Xiuxia Qin, Liqin Qi
Background: This study was designed to explore the correlation of connective tissue growth factor (CTGF), heme oxygenase (HO-1), neurotrophic factors (NT-3) with type 2 diabetic peripheral neuropathy, as well as the changes after immune cytokine alone and combined with cattleencephalon glycoside and ignotin treatment. Methods: Seventy-six patients with type 2 diabetes and peripheral neuropathy charged into People's Hospital of Rizhaolanshan, China from 2014-2016 were selected...
December 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/29249052/progressive-loss-of-hybrid-histidine-kinase-genes-during-the-evolution-of-budding-yeasts-saccharomycotina
#10
Anaïs Hérivaux, José L Lavín, Thomas Dugé de Bernonville, Patrick Vandeputte, Jean-Philippe Bouchara, Amandine Gastebois, José A Oguiza, Nicolas Papon
Two-component systems (TCSs) are widely distributed cell signaling pathways used by both prokaryotic and eukaryotic organisms to cope with a wide range of environmental cues. In fungi, TCS signaling routes, that mediate perception of stimuli, correspond to a multi-step phosphorelay between three protein families including hybrid histidine kinases (HHK), histidine phosphotransfer proteins (HPt) and response regulators (RR). The best known of these fungal transduction pathways remains the Sln1(HHK)-Ypd1(HPt)-Ssk1(RR) system that governs the high-osmolarity glycerol (HOG) mitogen-activated protein kinase (MAPK) pathway for osmo-adaptation in Saccharomyces cerevisiae...
December 16, 2017: Current Genetics
https://www.readbyqxmd.com/read/29236144/technological-properties-assessment-and-two-component-systems-distribution-of-streptococcus-thermophilus-strains-isolated-from-fermented-milk
#11
Tong Hu, Yishuang Zhang, Yanhua Cui, Chunyu Zhao, Xu Jiang, Xirong Zhu, Yu Wang, Xiaojun Qu
Streptococcus thermophilus is one of the economically most representatives of lactic acid bacteria, which is widely used as a starter to produce fermented milk products. In this study, 22 S. thermophilus strains were isolated from 26 fermented milk samples. Most isolates showed the ability to ferment a broad range of carbohydrates. Interestingly, eight strains are galactose positive, which is a desirable property in various industrial dairy fermentations. Four different nucleotide sequences were found in the galR-galK intergenic regions...
December 13, 2017: Archives of Microbiology
https://www.readbyqxmd.com/read/29229875/re-engineering-the-two-component-systems-as-light-regulated-in-escherichia-coli
#12
Siya Ma, Siwei Luo, L I Wu, Zhi Liang, Jia-Rui Wu
Bacteria live in environments with dynamic changes. To sense and respond to different external stimuli, bacteria make use of various sensor-response circuits, called two-component systems (TCSs). A TCS comprises a histidine protein kinase (HK) sensing environmental stimuli and a response regulator protein (RR) regulating downstream genes. The two components are coupled via a phosphorylation control mechanism. In a recent study, we adopted an optogenetics approach to re-engineer the sensor HKs in Escherichia coli as a light-sensing fusion protein...
December 2017: Journal of Biosciences
https://www.readbyqxmd.com/read/29216643/emerging-treatment-options-in-atopic-dermatitis-topical-therapies
#13
Uffe Nygaard, Mette Deleuran, Christian Vestergaard
Atopic dermatitis is a chronic inflammatory skin disorder affecting children and adults, with the majority presenting mild to moderate disease severity. The use of topical corticosteroids (TCSs) in combination with emollients has been the mainstay for treating mild to moderate atopic dermatitis since the 1950s, and as a supplement to systemic treatment in severe disease. However, while very effective, TCSs are often accompanied by poor adherence due to corticophobia (fear of using corticosteroids in patients or doctors), unwanted side effects, and in some cases insufficient clinical response...
December 8, 2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/29209465/two-component-signal-transduction-systems-in-oral-bacteria
#14
REVIEW
Renata O Mattos-Graner, Margaret J Duncan
We present an overview of how members of the oral microbiota respond to their environment by regulating gene expression through two-component signal transduction systems (TCSs) to support conditions compatible with homeostasis in oral biofilms or drive the equilibrium toward dysbiosis in response to environmental changes. Using studies on the sub-gingival Gram-negative anaerobe Porphyromonas gingivalis and Gram-positive streptococci as examples, we focus on the molecular mechanisms involved in activation of TCS and species specificities of TCS regulons...
2017: Journal of Oral Microbiology
https://www.readbyqxmd.com/read/29182512/global-mapping-of-mtra-binding-sites-links-mtra-to-regulation-of-its-targets-in-mycobacterium-tuberculosis
#15
Ayan Chatterjee, Arun Kumar Sharma, Amar Chandra Mahatha, Srijon Kaushik Banerjee, Manish Kumar, Sudipto Saha, Joyoti Basu, Manikuntala Kundu
Mycobacterium tuberculosis employs two-component systems (TCSs) for survival within its host. The TCS MtrAB is conserved among mycobacteria. The response regulator MtrA is essential in M. tuberculosis. The genome-wide chromatin immunoprecipitation (ChIP) sequencing performed in this study suggested that MtrA binds upstream of at least 45 genes of M. tuberculosis, including those involved in cell wall remodelling, stress responses, persistence and regulation of transcription. It binds to the promoter regions and regulates the peptidoglycan hydrolases rpfA and rpfC, which are required for resuscitation from dormancy...
November 28, 2017: Microbiology
https://www.readbyqxmd.com/read/29164075/disruption-of-two-component-system-lytsr-affects-forespore-engulfment-in-bacillus-thuringiensis
#16
Qi Peng, Jianbo Wu, Xiaomin Chen, Lili Qiu, Jie Zhang, Hongtao Tian, Fuping Song
Two-component regulatory systems (TCSs) play pivotal roles in bacteria sensing many different stimuli from environment. Here, we investigated the role of the LytSR TCS in spore formation in Bacillus thuringiensis (Bt) subsp. kurstaki HD73. lacZ gene fusions revealed that the transcription of the downstream genes, lrgAB, encoding two putative membrane-associated proteins, is regulated by LytSR. The sporulation efficiency of a lytSR mutant was significantly lower than that of wild-type HD73. A confocal microscopic analysis demonstrated that LytSR modulates the process of forespore engulfment...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29163430/pdtas-deficiency-affects-resistance-of-mycobacteria-to-ribosome-targeting-antibiotics
#17
Karolina Dadura, Renata Płocińska, Anna Rumijowska-Galewicz, Przemysław Płociński, Anna Żaczek, Bożena Dziadek, Andrzej Zaborowski, Jarosław Dziadek
Two-component regulatory systems (TCSSs) are key regulatory elements responsible for the adaptation of bacteria to environmental stresses. A classical TCSS is typically comprised of a sensory histidine kinase and a corresponding response regulator. Here, we used homologous recombination to construct a Mycobacterium smegmatis mutant defective in the synthesis of cytosolic histidine kinase PdtaS (Msmeg_1918). The resulting ΔpdtaS mutant strain was tested in the Phenotype Microarray screening system, which allowed us to identify aminoglycoside antibiotic sensitivity, tetracyclines antibiotic resistance as well as membrane transport and respiration, as the main processes affected by removal of pdtaS...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29137247/the-influence-of-marital-status-on-survival-in-patients-with-oral-tongue-squamous-cell-carcinoma
#18
Wei Sun, Zeting Qiu, Wulin Tan, Zhongqi Liu, Zhongxing Wang, Wenqi Huang, Minghui Cao
Marital status was found to be an independent prognostic factor for survival in several cancers. However related researches of oral tongue squamous cell carcinoma (OTSCC) are still rare. We explored the Surveillance, Epidemiology, and End Results (SEER) program and finally identified 14,194 patients with OTSCC. Kaplan-Meier analysis and multivariate Cox regression models were used to distinguish risk factors for overall survival (OS) and tumor cause-specific survival (TCSS). Widowed patients had the highest percentage of female, highest average ages and more prevalence with localized SEER Stage significantly, while patients in the single group were younger than other groups...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29098331/essential-two-component-systems-regulating-cell-envelope-functions-opportunities-for-novel-antibiotic-therapies
#19
Silvia T Cardona, Matthew Choy, Andrew M Hogan
Novel therapies are urgently needed to alleviate the current crisis of multiple drug-resistant infections. The bacterial signal transduction mechanisms, known as two-component systems (TCSs), are ideal targets of novel inhibitory molecules. Highly restricted to the bacterial world, TCSs control a diverse set of cellular functions, namely virulence, response to cell envelope stress, and drug efflux. Impaired regulation of any of these aspects could affect the susceptibility of bacterial pathogens to antibiotics, which highlights the potential of TCS as targets of antibiotic adjuvant therapies...
November 2, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/29067003/two-component-signal-transduction-systems-of-pathogenic-bacteria-as-targets-for-antimicrobial-therapy-an-overview
#20
REVIEW
Sandeep Tiwari, Syed B Jamal, Syed S Hassan, Paulo V S D Carvalho, Sintia Almeida, Debmalya Barh, Preetam Ghosh, Artur Silva, Thiago L P Castro, Vasco Azevedo
The bacterial communities in a wide range of environmental niches sense and respond to numerous external stimuli for their survival. Primarily, a source they require to follow up this communication is the two-component signal transduction system (TCS), which typically comprises a sensor Histidine kinase for receiving external input signals and a response regulator that conveys a proper change in the bacterial cell physiology. For numerous reasons, TCSs have ascended as convincing targets for antibacterial drug design...
2017: Frontiers in Microbiology
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