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https://www.readbyqxmd.com/read/28293750/factors-affecting-the-surgical-outcomes-of-tethered-cord-syndrome-in-adults-a-retrospective-study
#1
Anas Abdallah, Erhan Emel, Betül Güler Abdallah, Murad Asiltürk, Özden Erhan Sofuoğlu
This study aimed to find the factors that may affect the surgical outcomes of congenital tethered cord syndrome (TCS) in adults by evaluating the long-term surgical outcomes of 25 consecutive cases. Medical records of 79 TCS cases which underwent surgery in Bakırköy Research and Training Hospital for Neurology, Neurosurgery and Psychiatry (BRSHH), during an 11-year period from 2005 to 2015, were retrospectively reviewed. All adult cases (patient age > 18 years) were selected as the core sample used for this study...
March 14, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28240972/multi-institutional-assessment-of-adverse-health-outcomes-among-north-american-testicular-cancer-survivors-after-modern-cisplatin-based-chemotherapy
#2
Chunkit Fung, Howard D Sesso, Annalynn M Williams, Sarah L Kerns, Patrick Monahan, Mohammad Abu Zaid, Darren R Feldman, Robert J Hamilton, David J Vaughn, Clair J Beard, Christian K Kollmannsberger, Ryan Cook, Sandra Althouse, Shirin Ardeshir-Rouhani-Fard, Steve E Lipshultz, Lawrence H Einhorn, Sophie D Fossa, Lois B Travis
Purpose To provide new information on adverse health outcomes (AHOs) in testicular cancer survivors (TCSs) after four cycles of etoposide and cisplatin (EPX4) or three or four cycles of bleomycin, etoposide, cisplatin (BEPX3/BEPX4). Methods Nine hundred fifty-two TCSs > 1 year postchemotherapy underwent physical examination and completed a questionnaire. Multinomial logistic regression estimated AHOs odds ratios (ORs) in relation to age, cumulative cisplatin and/or bleomycin dose, time since chemotherapy, sociodemographic factors, and health behaviors...
February 27, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28229194/screening-level-assessment-of-metal-concentrations-in-streambed-sediments-and-floodplain-soils-within-the-grand-lake-watershed-in-northeastern-oklahoma-usa
#3
Ean M Garvin, Cas F Bridge, Meredith S Garvin
Metal releases have been received by the Grand Lake watershed from the Tri-State Mining District (TSMD) since the mid 1800s. To address data gaps in metal distributions in the Oklahoma portion of the watershed, streambed sediment and floodplain soil was sampled on various streams. The <63-µm fraction was analyzed for Cd, Pb, and Zn concentrations by portable X-ray fluorescence spectroscopy and inductively coupled plasma-mass spectrometry. Mean metal concentration results at reference transects indicated that background sediment/soil concentrations for Cd, Pb, and Zn within the watershed were 0...
February 22, 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28122066/yvqe-and-covrs-of-group-a-streptococcus-play-a-pivotal-role-in-viability-and-phenotypic-adaptations-to-multiple-environmental-stresses
#4
Amonrattana Roobthaisong, Chihiro Aikawa, Takashi Nozawa, Fumito Maruyama, Ichiro Nakagawa
Streptococcus pyogenes (group A Streptococcus, or GAS) is a human pathogen that causes a wide range of diseases. For successful colonization within a variety of host niches, GAS utilizes TCSs to sense and respond to environmental changes and adapts its pathogenic traits accordingly; however, many GAS TCSs and their interactions remain uncharacterized. Here, we elucidated the roles of a poorly characterized TCS, YvqEC, and a well-studied TCS, CovRS, in 2 different GAS strain SSI-1 and JRS4, respectively. Deletion of yvqE and yvqC in JRS4 resulted in lower cell viability and abnormality of cell division when compared to the wild-type strain under standard culture conditions, demonstrating an important role for YvqEC...
2017: PloS One
https://www.readbyqxmd.com/read/28076919/use-of-treatment-and-counseling-services-and-mind-body-techniques-by-students-with-emotional-and-behavioral-difficulties
#5
Wasantha Jayawardene, Ryan Erbe, David Lohrmann, Mohammad Torabi
BACKGROUND: School-based treatment and counseling services (TCSs) can integrate mind-body techniques (MBTs) to improve children's health, wellness, and academic performance. We aimed to describe the effect of school-based TCS on MBT-use among students experiencing difficulties with concentration, emotions, behaviors, and getting along (DCEBG). METHODS: National Health Interview Survey data were utilized (N2007  = 1225; N2012  = 1835). Logistic regression examined associations between TCS-type and MBT-use, while propensity score matching controlled for confounders in the prematch sample...
February 2017: Journal of School Health
https://www.readbyqxmd.com/read/28074004/signaling-by-two-component-system-noncognate-partners-promotes-intrinsic-tolerance-to-polymyxin-b-in-uropathogenic-escherichia-coli
#6
Kirsten R Guckes, Erin J Breland, Ellisa W Zhang, Sarah C Hanks, Navleen K Gill, Holly M S Algood, Jonathan E Schmitz, Charles W Stratton, Maria Hadjifrangiskou
Bacteria use two-component systems (TCSs) to react appropriately to environmental stimuli. Typical TCSs comprise a sensor histidine kinase that acts as a receptor coupled to a partner response regulator that coordinates changes in bacterial behavior, often through its activity as a transcriptional regulator. TCS interactions are typically confined to cognate pairs of histidine kinases and response regulators. We describe two distinct TCSs in uropathogenic Escherichia coli (UPEC) that interact to mediate a response to ferric iron...
January 10, 2017: Science Signaling
https://www.readbyqxmd.com/read/27999439/angucycline-antibiotic-waldiomycin-recognizes-common-structural-motif-conserved-in-bacterial-histidine-kinases
#7
Yoko Eguchi, Toshihide Okajima, Naoya Tochio, Yoichi Inukai, Riko Shimizu, Shuhei Ueda, Shoko Shinya, Takanori Kigawa, Tamo Fukamizo, Masayuki Igarashi, Ryutaro Utsumi
Two-component signal transduction systems (TCSs), composed of a histidine kinase sensor (HK) and its cognate response regulator, sense and respond to environmental changes and are related to the virulence of pathogens. TCSs are potential targets for alternative antibiotics and anti-virulence agents. Here we found that waldiomycin, an angucycline antibiotic that inhibits a growth essential HK, WalK, in Gram-positive bacteria, also inhibits several class I HKs from the Gram-negative Escherichia coli. NMR analyses and site-directed mutagenesis studies using the osmo-sensing EnvZ, a prototypical HK of E...
March 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/27966049/the-%C3%AF-54-dependent-two-component-system-regulating-sulfur-oxidization-sox-system-in-acidithiobacillus-caldus-and-some-chemolithotrophic-bacteria
#8
Li-Feng Li, Luo-Jie Fu, Jian-Qun Lin, Xin Pang, Xiang-Mei Liu, Rui Wang, Zhao-Bao Wang, Jian-Qiang Lin, Lin-Xu Chen
The sulfur oxidization (Sox) system is the central sulfur oxidization pathway of phototrophic and chemotrophic sulfur-oxidizing bacteria. Regulation and function of the Sox system in the chemotrophic Paracoccus pantotrophus has been elucidated; however, to date, no information is available on the regulation of this system in the chemolithotrophic Acidithiobacillus caldus, which is widely utilized in bioleaching. We described the novel tspSR-sox-like clusters in A. caldus and other chemolithotrophic sulfur-oxidizing bacteria containing Sox systems...
March 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27901334/differential-efficacy-of-methylcobalamin-and-alpha-lipoic-acid-treatment-on-negative-and-positive-symptoms-of-type-2-diabetic-peripheral-neuropathy
#9
Yajuan Han, Min Wang, Jie Shen, Zhen Zhang, Min Zhao, Jing Huang, Youming Chen, Zhi Chen, Yulan Hu, Yubing Wang
BACKGROUND: Diabetic hyperglycemia damages peripheral nerves by triggering ischemia, oxidative stress, and inflammation. Alpha-lipoic acid (ALA) and methylcobalamin (MC) are known to improve signs of diabetic peripheral neuropathy (DPN), possibly by enhancing neural and vascular endothelial cell metabolism and antioxidant capacity. We evaluated differences in efficacy following short-term MC or ALA treatment on DPN symptoms to guide clinical drug selection. METHODS: Forty DPN patients were randomly divided into MC and ALA treatment groups (n=20/20) and assessed by the Toronto Clinical Neuropathy Scoring System (TCSS), total symptom score (TSS), visual analog scale (VAS) of positive symptoms, and easy sensory test (EST) for negative symptoms before and after 2 weeks of treatment...
November 30, 2016: Minerva Endocrinologica
https://www.readbyqxmd.com/read/27872242/systematic-analysis-of-two-component-systems-in-citrobacter-rodentium-reveals-positive-and-negative-roles-in-virulence
#10
Jenny-Lee Thomassin, Jean-Mathieu Leclerc, Natalia Giannakopoulou, Lei Zhu, Kristiana Salmon, Andrea Portt, France Daigle, Hervé Le Moual, Samantha Gruenheid
Citrobacter rodentium is a murine pathogen used to model intestinal infections caused by the human diarrheal pathogens enterohemorrhagic and enteropathogenic Escherichia coli During infection, bacteria use two-component systems (TCSs) to detect changing environmental cues within the host, allowing for rapid adaptation by altering the expression of specific genes. In this study, 26 TCSs were identified in C. rodentium, and quantitative PCR (qPCR) analysis showed that they are all expressed during murine infection...
February 2017: Infection and Immunity
https://www.readbyqxmd.com/read/27871444/polyneuropathy-in-levodopa-treated-parkinson-s-patients
#11
Karol Szadejko, Krzysztof Dziewiatowski, Krzysztof Szabat, Piotr Robowski, Michał Schinwelski, Emilia Sitek, Jarosław Sławek
Recently published studies show that the prevalence of polyneuropathy (PNP) is higher in patients with Parkinson's disease (PD) than in age-matched controls. Its pathogenesis, however is a matter of controversy. The major hypothesis is the toxicity of high concentrations of homocysteine (Hcy) possibly related to levodopa (LD) therapy. The aim of the present study was to determine the prevalence of PNP, independent of other etiologies, and to determine the relationship to demographic and clinical factors in LD-treated Parkinson's patients...
December 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27795394/outer-membrane-vesicle-production-facilitates-lps-remodeling-and-outer-membrane-maintenance-in-salmonella-during-environmental-transitions
#12
Katherine E Bonnington, Meta J Kuehn
The ability of Gram-negative bacteria to carefully modulate outer membrane (OM) composition is essential to their survival. However, the asymmetric and heterogeneous structure of the Gram-negative OM poses unique challenges to the cell's successful adaption to rapid environmental transitions. Although mechanisms to recycle and degrade OM phospholipid material exist, there is no known mechanism by which to remove unfavorable lipopolysaccharide (LPS) glycoforms, except slow dilution through cell growth. As all Gram-negative bacteria constitutively shed OM vesicles (OMVs), we propose that cells may utilize OMV formation as a way to selectively remove environmentally disadvantageous LPS species...
October 18, 2016: MBio
https://www.readbyqxmd.com/read/27780931/marital-status-is-an-independent-prognostic-factor-for-tracheal-cancer-patients-an-analysis-of-the-seer-database
#13
Mu Li, Chen-Yang Dai, Yu-Ning Wang, Tao Chen, Long Wang, Ping Yang, Dong Xie, Rui Mao, Chang Chen
BACKGROUND: Although marital status is an independent prognostic factor in many cancers, its prognostic impact on tracheal cancer has not yet been determined. The goal of this study was to examine the relationship between marital status and survival in patients with tracheal cancer. RESULTS: Compared with unmarried patients (42.67%), married patients (57.33%) had better 5-year OS (25.64% vs. 35.89%, p = 0.009) and 5-year TCSS (44.58% vs. 58.75%, p = 0.004). Results of multivariate analysis indicated that marital status is an independent prognostic factor, with married patients showing better OS (hazard ratio [HR] = 0...
October 21, 2016: Oncotarget
https://www.readbyqxmd.com/read/27648280/long-term-outcomes-following-post-operative-radiotherapy-for-stage-i-ii-testicular-seminoma-an-australasian-single-institution-experience
#14
Wee Loon Ong, Lester Nazareth, Benjamin Hindson, Bronwyn Matheson, Jeremy L Millar
INTRODUCTION: The aim of the study is to review the long-term oncological outcomes and adverse effects of post-operative radiotherapy (PORT) for Stage I/II seminoma patients in an Australian radiation treatment centre. METHODS: This is a retrospective study of 125 patients with Stage I/II seminoma treated with PORT at the Alfred Health Radiation Oncology Service between 1992 and 2013. Patients were linked to the Victorian Cancer Registry to enable confirmation of survival and diagnosis of secondary malignancies (SM)...
September 2016: Journal of Medical Radiation Sciences
https://www.readbyqxmd.com/read/27622228/topical-corticosteroid-addiction-and-withdrawal-an-overview-for-gps
#15
Belinda Sheary
BACKGROUND: Topical corticosteroid (TCS) withdrawal (addiction) is a potential complication of TCS treatment, particularly where there has been an inappropriate long-term use of moderate-to-potent TCS on the face or genital area. TCS addiction and withdrawal is increasingly being discussed in social and mainstream media; however, it has received little attention in medical publications. Australian general practitioners (GPs) may come into contact with patients who have read material or watched videos about this condition...
June 2016: Australian Family Physician
https://www.readbyqxmd.com/read/27618760/a-comparative-proteomic-analysis-of-salmonella-typhimurium-under-the-regulation-of-the-rsta-rstb-and-phop-phoq-systems
#16
Trung-Kien Tran, Qiang-Qiang Han, Yixin Shi, Lin Guo
In pathogenic bacteria, the two-component regulatory systems (TCSs) play important roles in signal transduction and regulation of their pathogenesis. Here, we used quantitative proteomic methods to comparatively analyze functional networks under the control of the RstA/RstB system versus the PhoP/PhoQ system in Salmonella typhimurium. By comparing the proteomic profile from a wild-type strain to that from a ΔrstB strain or a ΔphoPQ strain under a condition known to activate these TCSs, we found that the levels of 159 proteins representing 6...
December 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27609999/the-energy-based-scaling-of-a-thin-current-sheet-case-study
#17
Yu L Sasunov, M L Khodachenko, I I Alexeev, E S Belenkaya, E I Gordeev, I V Kubyshkin
The influence of average plasma energy E~ on the half thickness ℓ of a thin current sheet (TCS) is investigated for three cases of TCSs crossings. The value of ℓ was estimated from the magnetic field data by means of Cluster observations. The obtained scaling values for TCSs, Z~=ℓ/ρT, where ρ T is the thermal Larmor radius, were compared with the scaling Zμ=22E~/T, where E~ and T are the average plasma energy and the temperature of plasma, which assumes a specific dynamics (conservation of magnetic flux through the trajectory segment) of the current carriers...
November 28, 2015: Geophysical Research Letters
https://www.readbyqxmd.com/read/27593774/management-of-tethered-cord-syndrome-in-adults-experience-of-23-cases
#18
Ozden Erhan Sofuoglu, Anas Abdallah, Erhan Emel, Ali Ender Ofluoglu, Muslum Gunes, Betul Guler
AIM: Tethered cord syndrome (TCS) is rarely diagnosed in adults. It is a complex clinicopathological entity that remains poorly understood. In this study, clinical outcomes of 23 consecutive congenital TCSs diagnosed in adults have been evaluated to establish a standard approach to treat congenital TCS diagnosed in adults. MATERIAL AND METHODS: Medical records were retrospectively reviewed in 73 cases of TCS who were underwent surgery in our hospital, between 2005 and 2014...
2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/27575438/the-rational-design-synthesis-and-antimicrobial-properties-of-thiophene-derivatives-that-inhibit-bacterial-histidine-kinases
#19
Thibaut Boibessot, Christopher P Zschiedrich, Alexandre Lebeau, David Bénimèlis, Catherine Dunyach-Rémy, Jean-Philippe Lavigne, Hendrik Szurmant, Zohra Benfodda, Patrick Meffre
The emergence of multidrug-resistant bacteria emphasizes the urgent need for novel antibacterial compounds targeting unique cellular processes. Two-component signal transduction systems (TCSs) are commonly used by bacteria to couple environmental stimuli to adaptive responses, are absent in mammals, and are embedded in various pathogenic pathways. To attenuate these signaling pathways, we aimed to target the TCS signal transducer histidine kinase (HK) by focusing on their highly conserved adenosine triphosphate-binding domain...
October 13, 2016: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27566839/cryopreservation-of-testicular-tissue-or-testicular-cell-suspensions-a-pivotal-step-in-fertility-preservation
#20
J Onofre, Y Baert, K Faes, E Goossens
BACKGROUND: Germ cell depletion caused by chemical or physical toxicity, disease or genetic predisposition can occur at any age. Although semen cryopreservation is the first reflex for preserving male fertility, this cannot help out prepubertal boys. Yet, these boys do have spermatogonial stem cells (SSCs) that able to produce sperm at the start of puberty, which allows them to safeguard their fertility through testicular tissue (TT) cryopreservation. SSC transplantation (SSCT), TT grafting and recent advances in in vitro spermatogenesis have opened new possibilities to restore fertility in humans...
August 27, 2016: Human Reproduction Update
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