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https://www.readbyqxmd.com/read/29662838/the-cpxa-cpxr-two-component-system-affects-biofilm-formation-and-virulence-in-actinobacillus-pleuropneumoniae
#1
Huan Li, Feng Liu, Wei Peng, Kang Yan, Haixu Zhao, Ting Liu, Hui Cheng, Peixi Chang, Fangyan Yuan, Huanchun Chen, Weicheng Bei
Gram-negative bacteria have evolved numerous two-component systems (TCSs) to cope with external environmental changes. The CpxA/CpxR TCS consisting of the kinase CpxA and the regulator CpxR, is known to be involved in the biofilm formation and virulence of Escherichia coli . However, the role of CpxA/CpxR remained unclear in Actinobacillus pleuropneumoniae , a bacterial pathogen that can cause porcine contagious pleuropneumonia (PCP). In this report, we show that CpxA/CpxR contributes to the biofilm formation ability of A...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29650958/phosphatase-activity-tunes-two-component-system-sensor-detection-threshold
#2
Brian P Landry, Rohan Palanki, Nikola Dyulgyarov, Lucas A Hartsough, Jeffrey J Tabor
Two-component systems (TCSs) are the largest family of multi-step signal transduction pathways in biology, and a major source of sensors for biotechnology. However, the input concentrations to which biosensors respond are often mismatched with application requirements. Here, we utilize a mathematical model to show that TCS detection thresholds increase with the phosphatase activity of the sensor histidine kinase. We experimentally validate this result in engineered Bacillus subtilis nitrate and E. coli aspartate TCS sensors by tuning their detection threshold up to two orders of magnitude...
April 12, 2018: Nature Communications
https://www.readbyqxmd.com/read/29563900/a-systematic-evaluation-of-the-two-component-systems-network-reveals-that-arlrs-is-a-key-regulator-of-catheter-colonization-by-staphylococcus-aureus
#3
Saioa Burgui, Carmen Gil, Cristina Solano, Iñigo Lasa, Jaione Valle
Two-component systems (TCS) are modular signal transduction pathways that allow cells to adapt to prevailing environmental conditions by modifying cellular physiology. Staphylococcus aureus has 16 TCSs to adapt to the diverse microenvironments encountered during its life cycle, including host tissues and implanted medical devices. S. aureus is particularly prone to cause infections associated to medical devices, whose surfaces coated by serum proteins constitute a particular environment. Identification of the TCSs involved in the adaptation of S...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29559812/a-cohort-study-on-the-risk-of-lymphoma-and-skin-cancer-in-users-of-topical-tacrolimus-pimecrolimus-and-corticosteroids-joint-european-longitudinal-lymphoma-and-skin-cancer-evaluation-joelle-study
#4
Jordi Castellsague, Josephina G Kuiper, Anton Pottegård, Ingegärd Anveden Berglind, Daniel Dedman, Lia Gutierrez, Brian Calingaert, Myrthe Pp van Herk-Sukel, Jesper Hallas, Anders Sundström, Arlene M Gallagher, James A Kaye, Carolina Pardo, Kenneth J Rothman, Susana Perez-Gutthann
Background: There is a concern that topical tacrolimus and pimecrolimus, indicated for second-line treatment of atopic dermatitis, may increase the risk of lymphoma and skin cancer, particularly in children. Objective: The aim of this study was to compare incidence rates (IRs) of lymphoma and skin cancer between new users of topical tacrolimus or pimecrolimus and users of moderate- to high-potency topical corticosteroids (TCSs) and untreated subjects. Methods: This is a multicenter cohort study with frequency matching by strata of propensity scores in population databases in the Netherlands, Denmark, Sweden, and the UK...
2018: Clinical Epidemiology
https://www.readbyqxmd.com/read/29543889/spdc-a-novel-virulence-factor-controls-histidine-kinase-activity-in-staphylococcus-aureus
#5
Olivier Poupel, Caroline Proux, Bernd Jagla, Tarek Msadek, Sarah Dubrac
The success of Staphylococcus aureus, as both a human and animal pathogen, stems from its ability to rapidly adapt to a wide spectrum of environmental conditions. Two-component systems (TCSs) play a crucial role in this process. Here, we describe a novel staphylococcal virulence factor, SpdC, an Abi-domain protein, involved in signal sensing and/or transduction. We have uncovered a functional link between the WalKR essential TCS and the SpdC Abi membrane protein. Expression of spdC is positively regulated by the WalKR system and, in turn, SpdC negatively controls WalKR regulon genes, effectively constituting a negative feedback loop...
March 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29534941/predicting-cardiovascular-disease-among-testicular-cancer-survivors-after-modern-cisplatin-based-chemotherapy-application-of-the-framingham-risk-score
#6
Darren R Feldman, Shirin Ardeshir-Rouhani-Fard, Patrick Monahan, Howard D Sesso, Chunkit Fung, Annalynn M Williams, Robert J Hamilton, David J Vaughn, Clair J Beard, Ryan Cook, Mohammad Abu Zaid, Steven E Lipshultz, Lawrence H Einhorn, Kevin C Oeffinger, Lois B Travis, Sophie D Fossa
BACKGROUND: Testicular cancer survivors (TCSs) are at increased risk of cardiovascular disease (CVD) after cisplatin-based chemotherapy (CBCT). Identifying at-risk survivors would allow early intervention, but risk prediction tools such as the Framingham Risk Score (FRS) have not been applied to TCSs given modern chemotherapy. METHODS: TCSs > 1 year post-CBCT were evaluated. Associations between FRS and clinical, socioeconomic, and lifestyle measures and treatment regimen (4 cycles, etoposide and cisplatin [EP × 4]); 3 or 4 cycles, bleomycin plus EP (BEP × 3, BEP × 4) were analyzed with general linear multivariable models...
February 5, 2018: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29515973/cohort-profile-the-danish-testicular-cancer-late-treatment-effects-cohort-dateca-late
#7
Michael Kreiberg, Mikkel Bandak, Jakob Lauritsen, Julie Wang Skøtt, Nanna Borup Johansen, Mads Agerbaek, Niels Vilstrup Holm, Christoffer Johansen, Gedske Daugaard
The cohort was set up in order to analyze late effects in long-term testicular cancer survivors (TCS) and to contribute to the design of future follow-up programs addressing and potentially preventing late effects. Data for this cross-sectional study were collected between January 1, 2014, and December 31, 2016, among living Danish TCS and 60% agreed to participate in the cohort ( N  = 2,572). Mean time since testicular cancer (TC) diagnosis was 18 years (range 7-33) and mean age of participants was 53 years (range 25-95)...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29487854/re-sensitizing-multidrug-resistant-bacteria-to-antibiotics-by-targeting-bacterial-response-regulators-characterization-and-comparison-of-interactions-between-2-aminoimidazoles-and-the-response-regulators-bfmr-from-acinetobacter-baumannii-and-qseb-from-francisella
#8
Morgan E Milton, Bradley M Minrovic, Danni L Harris, Brian Kang, David Jung, Caleb P Lewis, Richele J Thompson, Roberta J Melander, Daina Zeng, Christian Melander, John Cavanagh
2-aminoimidazole (2-AI) compounds inhibit the formation of bacterial biofilms, disperse preformed biofilms, and re-sensitize multidrug resistant bacteria to antibiotics. 2-AIs have previously been shown to interact with bacterial response regulators, but the mechanism of interaction is still unknown. Response regulators are one part of two-component systems (TCS). TCSs allow cells to respond to changes in their environment, and are used to trigger quorum sensing, virulence factors, and antibiotic resistance...
2018: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/29461592/health-related-quality-of-life-and-psychosocial-implications-in-testicular-cancer-survivors-a-literature-review
#9
F Cappuccio, S Rossetti, C Cavaliere, G Iovane, R Taibi, C D'Aniello, C Imbimbo, S Facchini, V Abate, D Barberio, G Facchini
OBJECTIVE: In this review, we focused our attention on Quality of Life (QoL) of testicular cancer survivors (TCSs), in general and in the most relevant areas. Several key findings have been highlighted in our review. MATERIALS AND METHODS: PubMed, MEDLINE and PsycINFO databases were consulted to find published studies, from 1980 to May 2017, that met our inclusion criteria. RESULTS: The majority of studies investigated older adult TCSs, while few studies on adolescent and young adult patients were available...
February 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29424663/a-large-scale-mutational-analysis-of-two-component-signaling-systems-of-lonsdalea-quercina-revealed-that-kdpd-kdpe-regulates-bacterial-virulence-against-host-poplar-trees
#10
Ruo-Lan Yang, Chao-Ying Deng, Jin-Wei Wei, Wei He, Ai-Ning Li, Wei Qian
Poplar, which is a dominant species in plant communities distributed in the northern hemisphere, is commonly used as a model plant in forestry studies. Poplar production can be inhibited by infections caused by bacteria, including Lonsdalea quercina subsp. populi, which is a Gram-negative bacterium responsible for bark canker disease. However, the molecular basis of the pathogenesis remains uncharacterized. In this study, we annotated the two-component signal transduction systems (TCSs) encoded by the L. quercina subsp...
February 9, 2018: Molecular Plant-microbe Interactions: MPMI
https://www.readbyqxmd.com/read/29419686/the-clinical-efficacy-of-epalrestat-combined-with-%C3%AE-lipoic-acid-in-diabetic-peripheral-neuropathy-protocol-for-a-systematic-review-and-meta-analysis
#11
Xiaotong Wang, Haixiong Lin, Shuai Xu, Yuanlin Jin, Ren Zhang
BACKGROUND: Diabetic peripheral neuropathy (DPN) is a common long-term complication of diabetes mellitus, affecting patients in the world. Epalrestat combined with α-lipoic acid (ALA) is the most frequent combine therapy used in the DPN researches. We aim to assess the effectiveness and safety of epalrestat combined with ALA in patients with DPN, compare with epalrestat alone. METHODS: We will search Cochrane Library, PubMed, Wanfang Data, China National Knowledge Infrastructure, VIP Chinese Science and Technology Journals Database, and Chinese Biomedical Database from inception until October 31th, 2017...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29410457/sensory-deprivation-in-staphylococcus-aureus
#12
Maite Villanueva, Begoña García, Jaione Valle, Beatriz Rapún, Igor Ruiz de Los Mozos, Cristina Solano, Miguel Martí, José R Penadés, Alejandro Toledo-Arana, Iñigo Lasa
Bacteria use two-component systems (TCSs) to sense and respond to environmental changes. The core genome of the major human pathogen Staphylococcus aureus encodes 16 TCSs, one of which (WalRK) is essential. Here we show that S. aureus can be deprived of its complete sensorial TCS network and still survive under growth arrest conditions similarly to wild-type bacteria. Under replicating conditions, however, the WalRK system is necessary and sufficient to maintain bacterial growth, indicating that sensing through TCSs is mostly dispensable for living under constant environmental conditions...
February 6, 2018: Nature Communications
https://www.readbyqxmd.com/read/29374286/evidence-of-cross-regulation-in-two-closely-related-pyruvate-sensing-systems-in-uropathogenic-escherichia-coli
#13
Bradley D Steiner, Allison R Eberly, Melanie N Hurst, Ellisa W Zhang, Hamilton D Green, Stefan Behr, Kirsten Jung, Maria Hadjifrangiskou
Two-component systems (TCSs) dictate many bacterial responses to environmental change via the activation of a membrane-embedded sensor kinase, which has molecular specificity for a cognate response regulator protein. However, although the majority of TCSs operate through seemingly strict cognate protein-protein interactions, there have been several reports of TCSs that violate this classical model of signal transduction. Our group has recently demonstrated that some of these cross-interacting TCSs function in a manner that imparts a fitness advantage to bacterial pathogens...
January 27, 2018: Journal of Membrane Biology
https://www.readbyqxmd.com/read/29354650/the-logics-of-metabolic-regulation-in-bacteria-challenges-biosensor-based-metabolic-engineering
#14
COMMENT
Matthieu Jules
Synthetic Biology (SB) aims at the rational design and engineering of novel biological functions and systems. By facilitating the engineering of living organisms, SB promises to facilitate the development of many new applications for health, biomanufacturing, and the environment. Over the last decade, SB promoted the construction of libraries of components enabling the fine-tuning of genetic circuits expression and the development of novel genome engineering methodologies for many organisms of interest. SB thus opened new perspectives in the field of metabolic engineering, which was until then mainly limited to (over)producing naturally synthesized metabolic compounds...
December 11, 2017: Microbial Cell
https://www.readbyqxmd.com/read/29339416/exploring-the-almost-unknown-archaeal-two-component-systems
#15
Tino Krell
Two-component systems (TCS) exist in bacteria and archaea. In contrast to the knowledge of bacterial TCSs, little information is available on their archaeal counterparts. In the current issue of Journal of Bacteriology , Galperin and coworkers present a bioinformatics analysis of TCS genes from archaeal genome sequences (M. Y. Galperin, K. S. Makarova, Y. I. Wolf, and E. V. Koonin, J Bacteriol 200:e00681-17, 2018, https://doi.org/10.1128/JB.00681-17). This study identifies different aspects in which TCS-mediated signaling differs in bacteria and archaea and forms a sound basis for the experimental design of studies to increase our knowledge of this poorly investigated protein family...
April 1, 2018: Journal of Bacteriology
https://www.readbyqxmd.com/read/29299752/backbone-resonance-assignment-of-the-response-regulator-protein-phob-n-f20d-from-escherichia-coli
#16
Xinhui Kou, Xinghong Liu, Yixiang Liu, Conggang Li, Maili Liu, Ling Jiang
PhoB is a response regulator of the PhoR/PhoB two-component signal transduction system that is involved in the regulation of the phosphate (Pho) regulon of Escherichia coli. PhoB has two domains, receiver domain and effector domain. The receiver domain can be phosphorylated by its cognate histidine kinase PhoR and the phosphorylation induces conformational changes of the full length protein of PhoB that promote the DNA binding and transcription. Three-dimensional crystal structures of PhoB receiver domain (PhoBN ) have been solved under apo or BeF3 - (a phosphoryl analog) binding forms and it has been found that PhoBN is dimerized in both situations...
April 2018: Biomolecular NMR Assignments
https://www.readbyqxmd.com/read/29290041/oligomeric-states-in-sodium-ion-dependent-regulation-of-cyanobacterial-histidine-kinase-2
#17
Iskander M Ibrahim, Liang Wang, Sujith Puthiyaveetil, Norbert Krauß, Jon Nield, John F Allen
Two-component signal transduction systems (TCSs) consist of sensor histidine kinases and response regulators. TCSs mediate adaptation to environmental changes in bacteria, plants, fungi and protists. Histidine kinase 2 (Hik2) is a sensor histidine kinase found in all known cyanobacteria and as chloroplast sensor kinase in eukaryotic algae and plants. Sodium ions have been shown to inhibit the autophosphorylation activity of Hik2 that precedes phosphoryl transfer to response regulators, but the mechanism of inhibition has not been determined...
December 30, 2017: Protoplasma
https://www.readbyqxmd.com/read/29259937/effects-of-immunocytokine-combined-with-cattle-encephalon-glycoside-and-ignotin-on-ctgf-ho-1-and-nt-3-in-patients-with-type-2-diabetic-peripheral-neuropathy
#18
Jianguo Sun, Hui Zheng, Xiuxia Qin, Liqin Qi
Background: This study was designed to explore the correlation of connective tissue growth factor (CTGF), heme oxygenase (HO-1), neurotrophic factors (NT-3) with type 2 diabetic peripheral neuropathy, as well as the changes after immune cytokine alone and combined with cattleencephalon glycoside and ignotin treatment. Methods: Seventy-six patients with type 2 diabetes and peripheral neuropathy charged into People's Hospital of Rizhaolanshan, China from 2014-2016 were selected...
December 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/29249052/progressive-loss-of-hybrid-histidine-kinase-genes-during-the-evolution-of-budding-yeasts-saccharomycotina
#19
Anaïs Hérivaux, José L Lavín, Thomas Dugé de Bernonville, Patrick Vandeputte, Jean-Philippe Bouchara, Amandine Gastebois, José A Oguiza, Nicolas Papon
Two-component systems (TCSs) are widely distributed cell signaling pathways used by both prokaryotic and eukaryotic organisms to cope with a wide range of environmental cues. In fungi, TCS signaling routes, that mediate perception of stimuli, correspond to a multi-step phosphorelay between three protein families including hybrid histidine kinases (HHK), histidine phosphotransfer proteins (HPt) and response regulators (RR). The best known of these fungal transduction pathways remains the Sln1(HHK)-Ypd1(HPt)-Ssk1(RR) system that governs the high-osmolarity glycerol (HOG) mitogen-activated protein kinase (MAPK) pathway for osmo-adaptation in Saccharomyces cerevisiae...
December 16, 2017: Current Genetics
https://www.readbyqxmd.com/read/29236144/technological-properties-assessment-and-two-component-systems-distribution-of-streptococcus-thermophilus-strains-isolated-from-fermented-milk
#20
Tong Hu, Yishuang Zhang, Yanhua Cui, Chunyu Zhao, Xu Jiang, Xirong Zhu, Yu Wang, Xiaojun Qu
Streptococcus thermophilus is one of the economically most representatives of lactic acid bacteria, which is widely used as a starter to produce fermented milk products. In this study, 22 S. thermophilus strains were isolated from 26 fermented milk samples. Most isolates showed the ability to ferment a broad range of carbohydrates. Interestingly, eight strains are galactose positive, which is a desirable property in various industrial dairy fermentations. Four different nucleotide sequences were found in the galR-galK intergenic regions...
December 13, 2017: Archives of Microbiology
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