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https://www.readbyqxmd.com/read/28607158/the-two-component-signal-transduction-system-vxrab-positively-regulates-vibrio-cholerae-biofilm-formation
#1
Jennifer K Teschler, Andrew T Cheng, Fitnat H Yildiz
Two-component signal transduction systems (TCSs), typically composed of a sensor histidine kinase (HK) and a response regulator (RR), are the primary mechanism by which pathogenic bacteria sense and respond to extracellular signals. The pathogenic bacterium Vibrio cholerae is no exception and encodes for 52 RR genes. Using in frame deletion mutants of each RR gene, we performed a systematic analysis of their role in V. cholerae biofilm formation. We determined that 7 RRs impacted expression of an essential biofilm gene and found that the recently characterized RR, VxrB, regulates expression of key structural and regulatory biofilm-genes in V...
June 12, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28544098/crystal-structure-of-the-sensor-domain-of-baes-from-serratia-marcescens-fs14
#2
Ya Zhang, Shenshen Qiu, Shanshan Jia, Dongqing Xu, Tingting Ran, Weiwu Wang
The sensor histidine kinases of two-component signal-transduction systems (TCSs) are essential for bacteria to adapt to variable environmental conditions. The two-component regulatory system BaeS/R increases multidrug and metal resistance in Salmonella and Escherichia coli. In this study, we report the X-ray structure of the periplasmic sensor domain of BaeS from Serratia marcescens FS14. The BaeS sensor domain (34-160) adopts a mixed α/β-fold containing a central four-stranded antiparallel β-sheet flanked by a long N-terminal α-helix and additional loops and a short C-terminal α-helix on each side...
May 24, 2017: Proteins
https://www.readbyqxmd.com/read/28536675/an-overview-of-two-component-signal-transduction-systems-implicated-in-extra-intestinal-pathogenic-e-coli-infections
#3
REVIEW
Erin J Breland, Allison R Eberly, Maria Hadjifrangiskou
Extra-intestinal pathogenic E. coli (ExPEC) infections are common in mammals and birds. The predominant ExPEC types are avian pathogenic E. coli (APEC), neonatal meningitis causing E. coli/meningitis associated E. coli (NMEC/MAEC), and uropathogenic E. coli (UPEC). Many reviews have described current knowledge on ExPEC infection strategies and virulence factors, especially for UPEC. However, surprisingly little has been reported on the regulatory modules that have been identified as critical in ExPEC pathogenesis...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28512092/quantitative-kinetic-analyses-of-shutting-off-a-two-component-system
#4
Rong Gao, Ann M Stock
Cells rely on accurate control of signaling systems to adapt to environmental perturbations. System deactivation upon stimulus removal is as important as activation of signaling pathways. The two-component system (TCS) is one of the major bacterial signaling schemes. In many TCSs, phosphatase activity of the histidine kinase (HK) is believed to play an essential role in shutting off the pathway and resetting the system to the prestimulus state. Two basic challenges are to understand the dynamic behavior of system deactivation and to quantitatively evaluate the role of phosphatase activity under natural cellular conditions...
May 16, 2017: MBio
https://www.readbyqxmd.com/read/28510688/two-component-systems-required-for-virulence-in-pseudomonas-aeruginosa
#5
V I Francis, E C Stevenson, S L Porter
Pseudomonas aeruginosa is a versatile opportunistic pathogen capable of infecting a broad range of hosts, in addition to thriving in a broad range of environmental conditions outside of hosts. With this versatility comes the need to tightly regulate its genome to optimise its gene expression and behaviour to the prevailing conditions. Two-component systems (TCSs) comprising sensor kinases and response regulators, play a major role in this regulation. This minireview discusses the growing number of two-component systems that have been implicated in the virulence of Pseudomonas aeruginosa, with a special focus on the emerging theme of multikinase networks, which are networks comprising multiple sensor kinases working together, sensing and integrating multiple signals to decide upon the best response...
May 16, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/28461451/a-novel-two-component-system-glur-k-involved-in-glutamate-sensing-and-uptake-in-streptomyces-coelicolor
#6
Lei Li, Weihong Jiang, Yinhua Lu
Two-component systems (TCSs), the predominant signal transduction pathways employed by bacteria, play important roles in physiological metabolism in Streptomyces Here, a novel TCS GluR-K (encoded by SCO5778-5779), which is located divergently from the gluABCD operon encoding a glutamate uptake system, was identified being involved in glutamate sensing and uptake as well as antibiotic biosynthesis in Streptomyces coelicolor Under the minimal medium (MM) supplemented with different concentrations of glutamate, deletion of gluR-K resulted in enhanced ACT but reduced RED and yCPK production, suggesting GluR-K plays a differential role in antibiotic biosynthesis...
May 1, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28438266/physiological-role-of-two-component-signal-transduction-systems-in-food-associated-lactic-acid-bacteria
#7
Vicente Monedero, Ainhoa Revilla-Guarinos, Manuel Zúñiga
Two-component systems (TCSs) are widespread signal transduction pathways mainly found in bacteria where they play a major role in adaptation to changing environmental conditions. TCSs generally consist of sensor histidine kinases that autophosphorylate in response to a specific stimulus and subsequently transfer the phosphate group to their cognate response regulators thus modulating their activity, usually as transcriptional regulators. In this review we present the current knowledge on the physiological role of TCSs in species of the families Lactobacillaceae and Leuconostocaceae of the group of lactic acid bacteria (LAB)...
2017: Advances in Applied Microbiology
https://www.readbyqxmd.com/read/28411370/nomograms-to-estimate-long-term-overall-survival-and-tongue-cancer-specific-survival-of-patients-with-tongue-squamous-cell-carcinoma
#8
Yun Li, Zhenyan Zhao, Xiaoxiao Liu, Jun Ju, Juan Chai, Qianwei Ni, Chao Ma, Tao Gao, Moyi Sun
The aim of this study was to construct nomograms to predict long-term overall survival (OS) and tongue cancer-specific survival (TCSS) of tongue squamous cell carcinoma (TSCC) patients based on clinical and tumor characteristics. Clinical, tumor, and treatment characteristics of 12,674 patients diagnosed with TSCC between 2004 and 2013 were collected from the Surveillance, Epidemiology, and End Results database. These patients were then divided into surgery and nonsurgery cohorts, and nomograms were developed for each of these groups...
May 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28293750/factors-affecting-the-surgical-outcomes-of-tethered-cord-syndrome-in-adults-a-retrospective-study
#9
Anas Abdallah, Erhan Emel, Betül Güler Abdallah, Murad Asiltürk, Özden Erhan Sofuoğlu
This study aimed to find the factors that may affect the surgical outcomes of congenital tethered cord syndrome (TCS) in adults by evaluating the long-term surgical outcomes of 25 consecutive cases. Medical records of 79 TCS cases which underwent surgery in Bakırköy Research and Training Hospital for Neurology, Neurosurgery and Psychiatry (BRSHH), during an 11-year period from 2005 to 2015, were retrospectively reviewed. All adult cases (patient age > 18 years) were selected as the core sample used for this study...
March 14, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28240972/multi-institutional-assessment-of-adverse-health-outcomes-among-north-american-testicular-cancer-survivors-after-modern-cisplatin-based-chemotherapy
#10
Chunkit Fung, Howard D Sesso, Annalynn M Williams, Sarah L Kerns, Patrick Monahan, Mohammad Abu Zaid, Darren R Feldman, Robert J Hamilton, David J Vaughn, Clair J Beard, Christian K Kollmannsberger, Ryan Cook, Sandra Althouse, Shirin Ardeshir-Rouhani-Fard, Steve E Lipshultz, Lawrence H Einhorn, Sophie D Fossa, Lois B Travis
Purpose To provide new information on adverse health outcomes (AHOs) in testicular cancer survivors (TCSs) after four cycles of etoposide and cisplatin (EPX4) or three or four cycles of bleomycin, etoposide, cisplatin (BEPX3/BEPX4). Methods Nine hundred fifty-two TCSs > 1 year postchemotherapy underwent physical examination and completed a questionnaire. Multinomial logistic regression estimated AHOs odds ratios (ORs) in relation to age, cumulative cisplatin and/or bleomycin dose, time since chemotherapy, sociodemographic factors, and health behaviors...
April 10, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28229194/screening-level-assessment-of-metal-concentrations-in-streambed-sediments-and-floodplain-soils-within-the-grand-lake-watershed-in-northeastern-oklahoma-usa
#11
Ean M Garvin, Cas F Bridge, Meredith S Garvin
Metal releases have been received by the Grand Lake watershed from the Tri-State Mining District (TSMD) since the mid 1800s. To address data gaps in metal distributions in the Oklahoma portion of the watershed, streambed sediment and floodplain soil was sampled on various streams. The <63-µm fraction was analyzed for Cd, Pb, and Zn concentrations by portable X-ray fluorescence spectroscopy and inductively coupled plasma-mass spectrometry. Mean metal concentration results at reference transects indicated that background sediment/soil concentrations for Cd, Pb, and Zn within the watershed were 0...
April 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28122066/yvqe-and-covrs-of-group-a-streptococcus-play-a-pivotal-role-in-viability-and-phenotypic-adaptations-to-multiple-environmental-stresses
#12
Amonrattana Roobthaisong, Chihiro Aikawa, Takashi Nozawa, Fumito Maruyama, Ichiro Nakagawa
Streptococcus pyogenes (group A Streptococcus, or GAS) is a human pathogen that causes a wide range of diseases. For successful colonization within a variety of host niches, GAS utilizes TCSs to sense and respond to environmental changes and adapts its pathogenic traits accordingly; however, many GAS TCSs and their interactions remain uncharacterized. Here, we elucidated the roles of a poorly characterized TCS, YvqEC, and a well-studied TCS, CovRS, in 2 different GAS strain SSI-1 and JRS4, respectively. Deletion of yvqE and yvqC in JRS4 resulted in lower cell viability and abnormality of cell division when compared to the wild-type strain under standard culture conditions, demonstrating an important role for YvqEC...
2017: PloS One
https://www.readbyqxmd.com/read/28076919/use-of-treatment-and-counseling-services-and-mind-body-techniques-by-students-with-emotional-and-behavioral-difficulties
#13
Wasantha Jayawardene, Ryan Erbe, David Lohrmann, Mohammad Torabi
BACKGROUND: School-based treatment and counseling services (TCSs) can integrate mind-body techniques (MBTs) to improve children's health, wellness, and academic performance. We aimed to describe the effect of school-based TCS on MBT-use among students experiencing difficulties with concentration, emotions, behaviors, and getting along (DCEBG). METHODS: National Health Interview Survey data were utilized (N2007  = 1225; N2012  = 1835). Logistic regression examined associations between TCS-type and MBT-use, while propensity score matching controlled for confounders in the prematch sample...
February 2017: Journal of School Health
https://www.readbyqxmd.com/read/28074004/signaling-by-two-component-system-noncognate-partners-promotes-intrinsic-tolerance-to-polymyxin-b-in-uropathogenic-escherichia-coli
#14
Kirsten R Guckes, Erin J Breland, Ellisa W Zhang, Sarah C Hanks, Navleen K Gill, Holly M S Algood, Jonathan E Schmitz, Charles W Stratton, Maria Hadjifrangiskou
Bacteria use two-component systems (TCSs) to react appropriately to environmental stimuli. Typical TCSs comprise a sensor histidine kinase that acts as a receptor coupled to a partner response regulator that coordinates changes in bacterial behavior, often through its activity as a transcriptional regulator. TCS interactions are typically confined to cognate pairs of histidine kinases and response regulators. We describe two distinct TCSs in uropathogenic Escherichia coli (UPEC) that interact to mediate a response to ferric iron...
January 10, 2017: Science Signaling
https://www.readbyqxmd.com/read/27999439/angucycline-antibiotic-waldiomycin-recognizes-common-structural-motif-conserved-in-bacterial-histidine-kinases
#15
Yoko Eguchi, Toshihide Okajima, Naoya Tochio, Yoichi Inukai, Riko Shimizu, Shuhei Ueda, Shoko Shinya, Takanori Kigawa, Tamo Fukamizo, Masayuki Igarashi, Ryutaro Utsumi
Two-component signal transduction systems (TCSs), composed of a histidine kinase sensor (HK) and its cognate response regulator, sense and respond to environmental changes and are related to the virulence of pathogens. TCSs are potential targets for alternative antibiotics and anti-virulence agents. Here we found that waldiomycin, an angucycline antibiotic that inhibits a growth essential HK, WalK, in Gram-positive bacteria, also inhibits several class I HKs from the Gram-negative Escherichia coli. NMR analyses and site-directed mutagenesis studies using the osmo-sensing EnvZ, a prototypical HK of E...
March 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/27966049/the-%C3%AF-54-dependent-two-component-system-regulating-sulfur-oxidization-sox-system-in-acidithiobacillus-caldus-and-some-chemolithotrophic-bacteria
#16
Li-Feng Li, Luo-Jie Fu, Jian-Qun Lin, Xin Pang, Xiang-Mei Liu, Rui Wang, Zhao-Bao Wang, Jian-Qiang Lin, Lin-Xu Chen
The sulfur oxidization (Sox) system is the central sulfur oxidization pathway of phototrophic and chemotrophic sulfur-oxidizing bacteria. Regulation and function of the Sox system in the chemotrophic Paracoccus pantotrophus has been elucidated; however, to date, no information is available on the regulation of this system in the chemolithotrophic Acidithiobacillus caldus, which is widely utilized in bioleaching. We described the novel tspSR-sox-like clusters in A. caldus and other chemolithotrophic sulfur-oxidizing bacteria containing Sox systems...
March 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27901334/differential-efficacy-of-methylcobalamin-and-alpha-lipoic-acid-treatment-on-negative-and-positive-symptoms-of-type-2-diabetic-peripheral-neuropathy
#17
Yajuan Han, Min Wang, Jie Shen, Zhen Zhang, Min Zhao, Jing Huang, Youming Chen, Zhi Chen, Yulan Hu, Yubing Wang
BACKGROUND: Diabetic hyperglycemia damages peripheral nerves by triggering ischemia, oxidative stress, and inflammation. Alpha-lipoic acid (ALA) and methylcobalamin (MC) are known to improve signs of diabetic peripheral neuropathy (DPN), possibly by enhancing neural and vascular endothelial cell metabolism and antioxidant capacity. We evaluated differences in efficacy following short-term MC or ALA treatment on DPN symptoms to guide clinical drug selection. METHODS: Forty DPN patients were randomly divided into MC and ALA treatment groups (n=20/20) and assessed by the Toronto Clinical Neuropathy Scoring System (TCSS), total symptom score (TSS), visual analog scale (VAS) of positive symptoms, and easy sensory test (EST) for negative symptoms before and after 2 weeks of treatment...
November 30, 2016: Minerva Endocrinologica
https://www.readbyqxmd.com/read/27872242/systematic-analysis-of-two-component-systems-in-citrobacter-rodentium-reveals-positive-and-negative-roles-in-virulence
#18
Jenny-Lee Thomassin, Jean-Mathieu Leclerc, Natalia Giannakopoulou, Lei Zhu, Kristiana Salmon, Andrea Portt, France Daigle, Hervé Le Moual, Samantha Gruenheid
Citrobacter rodentium is a murine pathogen used to model intestinal infections caused by the human diarrheal pathogens enterohemorrhagic and enteropathogenic Escherichia coli During infection, bacteria use two-component systems (TCSs) to detect changing environmental cues within the host, allowing for rapid adaptation by altering the expression of specific genes. In this study, 26 TCSs were identified in C. rodentium, and quantitative PCR (qPCR) analysis showed that they are all expressed during murine infection...
February 2017: Infection and Immunity
https://www.readbyqxmd.com/read/27871444/polyneuropathy-in-levodopa-treated-parkinson-s-patients
#19
Karol Szadejko, Krzysztof Dziewiatowski, Krzysztof Szabat, Piotr Robowski, Michał Schinwelski, Emilia Sitek, Jarosław Sławek
Recently published studies show that the prevalence of polyneuropathy (PNP) is higher in patients with Parkinson's disease (PD) than in age-matched controls. Its pathogenesis, however is a matter of controversy. The major hypothesis is the toxicity of high concentrations of homocysteine (Hcy) possibly related to levodopa (LD) therapy. The aim of the present study was to determine the prevalence of PNP, independent of other etiologies, and to determine the relationship to demographic and clinical factors in LD-treated Parkinson's patients...
December 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27795394/outer-membrane-vesicle-production-facilitates-lps-remodeling-and-outer-membrane-maintenance-in-salmonella-during-environmental-transitions
#20
Katherine E Bonnington, Meta J Kuehn
The ability of Gram-negative bacteria to carefully modulate outer membrane (OM) composition is essential to their survival. However, the asymmetric and heterogeneous structure of the Gram-negative OM poses unique challenges to the cell's successful adaption to rapid environmental transitions. Although mechanisms to recycle and degrade OM phospholipid material exist, there is no known mechanism by which to remove unfavorable lipopolysaccharide (LPS) glycoforms, except slow dilution through cell growth. As all Gram-negative bacteria constitutively shed OM vesicles (OMVs), we propose that cells may utilize OMV formation as a way to selectively remove environmentally disadvantageous LPS species...
October 18, 2016: MBio
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