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https://www.readbyqxmd.com/read/28926480/postconcussive-symptoms-over-the-first-14-days-after-mild-traumatic-brain-injury-an-experience-sampling-study
#1
Maria Pacella, Arjun Prabhu, Julia Morley, Stephanie Huang, Brian Suffoletto
OBJECTIVE: This study examined changes in postconcussive symptoms (PCS) over the acute postinjury recovery period, focusing on how daily PCSs differ between mild traumatic brain injury (mTBI) and other injury types. SETTING: An urban emergency department (ED) in Western Pennsylvania. SUBJECTS: A total of 108 adult patients with trauma being discharged from the ED were recruited and grouped by injury type: mild TBI (mTBI; n = 39), head injury without mTBI (HI: n = 16), and non-head-injured trauma controls (TCs: n = 53)...
September 18, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28923575/radioresistance-of-the-breast-tumor-is-highly-correlated-to-its-level-of-cancer-stem-cell-and-its-clinical-implication-for-breast-irradiation
#2
Xiangrong Sharon Qi, Frank Pajonk, Susan McCloskey, Daniel A Low, Patrick Kupelian, Michael Steinberg, Ke Sheng
BACKGROUND AND PURPOSE: Growing evidence suggested the coexistence of cancer stem cells (CSCs) within solid tumors. We aimed to study radiosensitivity parameters for the CSCs and differentiated tumor cells (TCs) and the correlation of the fractions of CSCs to the overall tumor radioresistance. MATERIAL AND METHODS: Surviving fractions of breast cancer cell lines were analyzed using a dual-compartment Linear-quadratic model with independent fitting parameters: radiosensitive αTC, βTC, αCSC, βCSC, and fraction of CSCs f...
September 15, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28923010/the-role-of-the-two-component-systems-cpx-and-arc-in-protein-alterations-upon-gentamicin-treatment-in-escherichia-coli
#3
Emina Ćudić, Kristin Surmann, Gianna Panasia, Elke Hammer, Sabine Hunke
BACKGROUND: The aminoglycoside antibiotic gentamicin was supposed to induce a crosstalk between the Cpx- and the Arc-two-component systems (TCS). Here, we investigated the physical interaction of the respective TCS components and compared the results with their respective gene expression and protein abundance. The findings were interpreted in relation to the global proteome profile upon gentamicin treatment. RESULTS: We observed specific interaction between CpxA and ArcA upon treatment with the aminoglycoside gentamicin using Membrane-Strep-tagged protein interaction experiments (mSPINE)...
September 18, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28922793/diurnal-cycling-transcription-factors-of-pineapple-revealed-by-genome-wide-annotation-and-global-transcriptomic-analysis
#4
Anupma Sharma, Ching Man Wai, Ray Ming, Qingyi Yu
Circadian clock provides fitness advantage by coordinating internal metabolic and physiological processes to external cyclic environments. Core clock components exhibit daily rhythmic changes in gene expression, and the majority of them are transcription factors (TFs) and transcription coregulators (TCs). We annotated 1,398 TFs from 67 TF families and 80 TCs from 20 TC families in pineapple, and analyzed their tissue-specific and diurnal expression patterns. Approximately 42% of TFs and 45% of TCs displayed diel rhythmic expression, including 177 TF/TCs cycling only in the nonphotosynthetic leaf tissue, 247 cycling only in the photosynthetic leaf tissue, and 201 cycling in both...
September 1, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/28918325/a-novel-lc-ms-ms-method-for-the-quantitative-measurement-of-the-acetate-content-in-pharmaceutical-peptides
#5
Rani J Qasem, Ibrahim K Farh, Mohammed A Al Essa
Most pharmaceutical peptides are supplied as acetate salts and the relative amount of acetate to peptide in the final product is one quality criterion required by regulatory agencies to approve the product for clinical use. The objective of the present study was to develop a validated LC-MS/MS method that allows the quantitative determination of the acetate content in pharmaceutical peptide preparations and simultaneous monitoring and collection of qualitative and quantitative information on the peptide during manufacture and in the final product...
September 6, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28912890/glioma-dual-targeting-nanohybrid-protein-toxin-constructed-by-intein-mediated-site-specific-ligation-for-multistage-booster-delivery
#6
Yingzhi Chen, Meng Zhang, Hongyue Jin, Dongdong Li, Fan Xu, Aihua Wu, Jinyu Wang, Yongzhuo Huang
Malignant glioma is one of the most untreatable cancers because of the formidable blood-brain barrier (BBB), through which few therapeutics can penetrate and reach the tumors. Biologics have been booming in cancer therapy in the past two decades, but their application in brain tumor has long been ignored due to the impermeable nature of BBB against effective delivery of biologics. Indeed, it is a long unsolved problem for brain delivery of macromolecular drugs, which becomes the Holy Grail in medical and pharmaceutical sciences...
2017: Theranostics
https://www.readbyqxmd.com/read/28910731/triclosan-removal-from-surface-water-by-ozonation-kinetics-and-by-products-formation
#7
Kemal B Orhon, Aybala Koc Orhon, Filiz B Dilek, Ulku Yetis
Removal of triclosan from surface water by ozonation was investigated. The results showed that complete elimination of triclosan from a surface water bearing 1-5 mg/L triclosan via continuous ozonation at 5 mg/L, require an ozonation time of 20-30 min depending on pH. Triclosan oxidation followed pseudo-first order kinetics with an apparent reaction rate constant varying from 0.214 min(-1) to 0.964 min(-1) depending on pH, initial triclosan concentration and water composition. Although the effect of pH was complex due to possible existence of different moieties, higher TCS removal efficiencies were obvious at weak-base conditions...
September 11, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28910587/trichosanthin-attenuates-vascular-injury-induced-neointimal-hyperplasia-following-balloon-catheter-injury-in-rats
#8
Min Qiu, Zheng Yang, Xiao-Hua Guo, Yu-Ting Song, Ming An, Guo-Jun Zhao, Miao Song, Xiao-Min Zhao, Yun-Shan Zhao, Quan-Li Liu
Trichosanthin (TCS), isolated from the root tuber of Trichosantheskirilowii, a well-known traditional Chinese medicinal plant, belonging to the Cucurbitaceae family, was found to exhibit numerous biological and pharmacological activities including anti-inflammatory. However, the effects of TCS on arterial injury induced neointimal hyperplasia and inflammatory cell infiltration remains poorly understood. The aim of study was to examine the effectiveness of TCS on arterial injury-mediated inflammatory processes and underlying mechanisms...
September 14, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28910447/orexin-a-suppresses-signal-transmission-to-dopaminergic-amacrine-cells-from-outer-and-inner-retinal-photoreceptors
#9
Sheng-Nan Qiao, Wei Zhou, Lei-Lei Liu, Dao-Qi Zhang, Yong-Mei Zhong
Purpose: The neuropeptides orexin-A and orexin-B are widely expressed in the vertebrate retina; however, their role in visual function is unclear. This study investigates whether and how orexins modulate signal transmission to dopaminergic amacrine cells (DACs) from both outer retinal photoreceptors (rods and cones) and inner retinal photoreceptors (melanopsin-expressing intrinsically photosensitive retinal ganglion cells [ipRGCs]). Methods: A whole-cell voltage-clamp technique was used to record light-induced responses from genetically labeled DACs in flat-mount mouse retinas...
September 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28899552/the-use-of-dissolvable-layered-double-hydroxide-components-in-an-in-situ-solid-phase-extraction-for-chromatographic-determination-of-tetracyclines-in-water-and-milk-samples
#10
Nattaphorn Phiroonsoontorn, Sira Sansuk, Yanawath Santaladchaiyakit, Supalax Srijaranai
This research presents a simple and green in situ solid phase extraction (is-SPE) combined with high-performance liquid chromatography (HPLC) for the simultaneous analysis of tetracyclines (TCs) including tetracycline, oxytetracycline, and chlortetracycline. In is-SPE, TCs were efficiently extracted through the precipitation formation of dissolvable layered double hydroxides (LDHs) by mixing the LDH components such as magnesium and aluminum ions (both in metal chloride salts) thoroughly in an alkaline sample solution...
September 4, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28894221/temperature-controlled-direct-imprinting-of-ag-ionic-ink-flexible-metal-grid-transparent-conductors-with-enhanced-electromechanical-durability
#11
Yong Suk Oh, Hyesun Choi, Jaeho Lee, Hyunwoo Lee, Dong Yun Choi, Sung-Uk Lee, Kyeong-Soo Yun, Seunghyup Yoo, Taek-Soo Kim, Inkyu Park, Hyung Jin Sung
Next-generation transparent conductors (TCs) require excellent electromechanical durability under mechanical deformations as well as high electrical conductivity and transparency. Here we introduce a method for the fabrication of highly conductive, low-porosity, flexible metal grid TCs via temperature-controlled direct imprinting (TCDI) of Ag ionic ink. The TCDI technique based on two-step heating is capable of not only stably capturing the Ag ionic ink, but also reducing the porosity of thermally decomposed Ag nanoparticle structures by eliminating large amounts of organic complexes...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28891010/effect-of-hydrophobicity-of-pharmaceuticals-and-personal-care-products-for-adsorption-on-activated-carbon-adsorption-isotherms-kinetics-and-mechanism
#12
Harkirat Kaur, Amit Bansiwal, Girivyankatesh Hippargi, Girish R Pophali
Adsorption of three pharmaceuticals and personal care products (PPCPs), namely caffeine, ibuprofen and triclosan on commercial powdered activated carbon was examined in aqueous medium. The contaminants were chosen based on their diverse log Kow (octanol-water partition coefficient) viz. - 0.07 for caffeine, 3.97 for ibuprofen and 4.76 for triclosan to examine the role of hydrophobicity on adsorption process. The adsorbent characterisation was achieved using BET surface area, SEM, pore size distribution studies and FTIR...
September 11, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28890208/role-of-orexin-receptors-in-the-ventral-tegmental-area-on-acquisition-and-expression-of-morphine-induced-conditioned-place-preference-in-the-rats
#13
Sharareh Farahimanesh, Shahram Zarrabian, Abbas Haghparast
The orexins are hypothalamic neuropeptides and their role in reward processing and drug addiction has been demonstrated. The extent of involvement of each orexin receptor in the acquisition and expression of conditioned place preference (CPP) for morphine is still a matter of controversy. We investigated the functional differences between orexin-1 and -2 receptor blockade in the ventral tegmental area (VTA) on the acquisition and expression of morphine CPP. A total of 86 adult male Wistar rats weighing 250±30g (age 7-8weeks) received intra-VTA microinjection of either SB334867 (0...
September 4, 2017: Neuropeptides
https://www.readbyqxmd.com/read/28889006/role-of-intra-accumbal-orexin-receptors-in-the-acquisition-of-morphine-induced-conditioned-place-preference-in-the-rats
#14
Mirmohammadali Mirramezani Alizamini, Zahra Farzinpour, Somayeh Ezzatpanah, Abbas Haghparast
Orexin receptor shave essential role in the induction of reward-related behaviors to several drugs of abuse. In the present study, we investigated the effects of bilateral administration of SB334867, as an orexin-1 receptor antagonist, and TCS OX2 29, as an orexin-2 receptor antagonist, into the nucleus accumbens (NAc) on the acquisition of morphine-induced conditioned place preference (CPP) in the rats. Adult male Wistar rats (n=80; 220-250g) were entered in a CPP paradigm. Bilateral microinjections of different doses of SB334867 (1, 3, 10 and 30nM) or TCS OX2 29 (3, 10, 30 and 100nM) into the NAc (0...
September 6, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28870587/the-value-of-midbrain-morphology-in-predicting-prognosis-in-chronic-disorders-of-consciousness-a-preliminary-ultrasound-study
#15
Antonino Chillura, Antonino Naro, Katia Micchia, Alessia Bramanti, Placido Bramanti, Rocco Salvatore Calabrò
Transcranial sonography (TCS) of the brainstem is currently used to support the clinical diagnosis of movement disorders. The aim of the study was to assess the usefulness of midbrain TCS in assessing outcome in patients with Chronic Disorders of Consciousness (DOC). Eleven patients with Minimally Conscious State (MCS) and Unresponsive Wakefulness Syndrome (UWS) were included in the study. We measured the area and echogenicity of the midbrain by encoding and digitally analyzing the corresponding images from the orbitomeatal plane, the morphology of brain parenchyma from the thalamic and cella media plane, and the intracranial circulation...
September 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28869716/identification-of-chimeric-%C3%AE-%C3%AE-%C3%AE-diterpene-synthases-possessing-both-type-ii-terpene-cyclase-and-prenyltransferase-activities
#16
Ikuro Abe, Takaaki Mitsuhashi, Masahiro Okada
We identified two unusual diterpene synthases composed of three domains (α, β, and γ) from fungal Penicillium species. They are the first enzymes found to possess both Type II terpene cyclase (TC) and prenyltransferase (PT) activities. These enzymes were characterized by heterologous expression in Aspergillus oryzae and in vitro experiments with wild-type, mutated, and truncated enzymes. The results revealed that the α domain in the C-terminal region of these enzymes was responsible for the PT activity, while the βγ domains in the N-terminal region composed the Type II TC, and formed copalyl diphosphate 2...
September 4, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28868633/a-5-year-randomized-trial-on-the-safety-and-efficacy-of-pimecrolimus-in-atopic-dermatitis-a-critical-appraisal
#17
S Weidinger, H Baurecht, J Schmitt
AIM: The PETITE study (Sigurgeirsson et al.) aimed to compare safety and efficacy of pimecrolimus 1% cream (PIM) and low-to-medium-potency topical corticosteroids (TCS) in children with mild-to-moderate atopic dermatitis (AD). SETTING AND DESIGN: Participants of this 5-year drug-company sponsored multicentre, open-label, parallel-group trial were recruited between April 2004 and October 2005. No details are reported regarding the study sites. STUDY EXPOSURE: Infants aged ≥ 3 to < 12 months with mild-to-moderate AD were randomly assigned in a 1 : 1 ratio to receive either PIM or a low- or medium-potency TCS cream/ointment for 5 years...
September 4, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28865346/prevalence-of-depressive-symptoms-and-their-association-with-brainstem-raphe-echogenicity-in-patients-with-parkinson-s-disease-and-non-pd-controls
#18
Toomas Toomsoo, René Randver, Inga Liepelt-Scarfone, Liis Kadastik-Eerme, Toomas Asser, Inna Rubanovits, Daniela Berg, Pille Taba
Despite advances in diagnostics and clinical recognition, depressive symptoms in Parkinson's disease (PD) exceeding normal limits remain effectively untreated. In this study, we report on the prevalence and severity of depressive symptoms as well as their association with brainstem raphe echogenicity in patients with PD and non-PD controls. The study included 266 Estonian PD patients and 168 age- and education-matched controls. Demographic and clinical data was documented. Brainstem raphe (BR) was visualized by transcranial sonography (TCS)...
August 16, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28861826/in-vivo-interaction-studies-by-measuring-f%C3%A3-rster-resonance-energy-transfer-through-fluorescence-lifetime-imaging-microscopy-fret-flim
#19
Florian Fäßler, Peter Pimpl
Combinations of multiple fluorescent fusion proteins are commonly generated and used for colocalization studies in live cell imaging but also biochemical analysis of protein-protein interactions by co-immunoprecipitation in vitro. Advanced microscopy techniques like Förster resonance energy transfer through fluorescence lifetime imaging microscopy (FRET/FLIM) nowadays enable the combination of both approaches. This opens up the possibility to perform a location-specific protein-protein interaction analysis in vivo...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28859275/investigation-of-triclosan-contamination-on-microbial-biomass-and-other-soil-health-indicators
#20
Morkel Zaayman, Alma Siggins, Dave Horne, Hamish Lowe, Jacqui Horswell
Triclosan (TCS) is an antimicrobial compound found in personal care products, and consequently in greywater. After its release to the environment, it continues its antimicrobial action on indigenous microbial communities. Little is known about the environmental impacts of high levels of TCS, which may occur due to accumulation following long-term greywater application to soil. Soil microcosms were established using a silty clay loam and augmented with a range of TCS concentrations ranging from 500 to 7500 mg kg-1...
September 1, 2017: FEMS Microbiology Letters
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