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https://www.readbyqxmd.com/read/27923586/assessment-of-traditional-and-improved-stove-use-on-household-air-pollution-and-personal-exposures-in-rural-western-kenya
#1
Fuyuen Yip, Bryan Christensen, Kanta Sircar, Luke Naeher, Nigel Bruce, David Pennise, Matthew Lozier, Tamara Pilishvili, Jennifer Loo Farrar, Debbi Stanistreet, Ronald Nyagol, Justus Muoki, Lindsey de Beer, Michael Sage, Vikas Kapil
BACKGROUND: Over 40% of the world's population relies on solid fuels for heating and cooking. Use of improved biomass cookstoves (ICS) has the potential to reduce household air pollution (HAP). OBJECTIVES: As part of an evaluation to identify ICS for use in Kenya, we collected indoor air and personal air samples to assess differences between traditional cookstoves (TCS) and ICS. METHODS: We conducted a cross-over study in 2012 in two Kenyan villages; up to six different ICS were installed in 45 households during six two-week periods...
December 3, 2016: Environment International
https://www.readbyqxmd.com/read/27920720/validation-of-online-versions-of-tinnitus-questionnaires-translated-into-swedish
#2
Karolina Müller, Niklas K Edvall, Esma Idrizbegovic, Robert Huhn, Rilana Cima, Viktor Persson, Constanze Leineweber, Hugo Westerlund, Berthold Langguth, Winfried Schlee, Barbara Canlon, Christopher R Cederroth
Background: Due to the lack of objective measures for assessing tinnitus, its clinical evaluation largely relies on the use of questionnaires and psychoacoustic tests. A global assessment of tinnitus burden would largely benefit from holistic approaches that not only incorporate measures of tinnitus but also take into account associated fears, emotional aspects (stress, anxiety, and depression), and quality of life. In Sweden, only a few instruments are available for assessing tinnitus, and the existing tools lack validation...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27910751/recent-advances-in-pharmacotherapeutic-paradigm-of-mild-to-recalcitrant-atopic-dermatitis
#3
Zahid Hussain, Shariza Sahudin, Hnin Ei Thu, Ahmad Nazrun Shuid, Syed Nasir Abbas Bukhari, Endang Kumolosasi
Atopic dermatitis (AD) is a common, chronic skin inflammatory disorder characterized by perivascular infiltration of immunoglobulin E (IgE), T lymphocytes, and mast cells. The key factors responsible for the pathophysiology of this disease are immunological disorders and defects in epidermal barrier properties. Pruritus, intense itching, psychological stress, deprived physical and mental performance, and sleep disturbance are the hallmark features of this dermatological disorder. Preventive interventions such as educational programs, avoidance of allergens, and exclusive care toward the skin could play a partial role in suppressing the symptoms...
2016: Critical Reviews in Therapeutic Drug Carrier Systems
https://www.readbyqxmd.com/read/27906750/role-of-orexin-2-and-cb1-receptors-within-the-periaqueductal-gray-matter-in-lateral-hypothalamic-induced-antinociception-in-rats
#4
Mohammad-Hossein Esmaeili, Zahra Reisi, Somayeh Ezzatpanah, Abbas Haghparast
Orexin plays an important role in pain modulation. Orexin-1 and orexin-2 receptors (Ox1r and Ox2r) are found at high density in the ventrolateral periaqueductal gray matter (vlPAG). Our previous study showed that chemical stimulation of the lateral hypothalamus with carbachol induces antinociception in the tail-flick test, a model of acute pain, and Ox1r-mediated antinociception in the vlPAG is modulated by the activity of vlPAG CB1 receptors. In the current study, TCS OX2 29, an Ox2r antagonist (5, 15, 50, 150, and 500 nmol/l), was microinjected into the vlPAG 5 min before the administration of carbachol (125 nmol/l)...
November 30, 2016: Behavioural Pharmacology
https://www.readbyqxmd.com/read/27903139/diversion-of-veterans-with-criminal-justice-involvement-to-treatment-courts-participant-characteristics-and-outcomes
#5
Jack Tsai, Bessie Flatley, Wesley J Kasprow, Sean Clark, Andrea Finlay
OBJECTIVE: This study compared characteristics and outcomes between veterans who participated in veterans treatment courts (VTCs) and veterans involved in criminal justice who participated in other treatment courts (TCs) or who participated in neither VTCs or TCs. METHODS: Data from 22,708 veterans (N=8,083 VTC participants, 680 participants in other TCs [other-TC participants], and 13,945 participants in neither VTCs nor TCs [non-TC participants]) in the Veterans Justice Outreach (VJO) program were analyzed by using multilevel regression models...
December 1, 2016: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/27898200/transcranial-sonography-in-idiopathic-rem-sleep-behavior-disorder-and-multiple-system-atrophy
#6
Xudong Li, Shuang Xue, Shuhong Jia, Zhi Zhou, Yanan Qiao, Chunlei Hou, Kun Wei, Wenjing Zheng, Pei Rong, Jinsong Jiao
AIMS: We investigated preclinical abnormalities revealed by transcranial sonography (TCS) in patients with idiopathic REM sleep behavior disorder (iRBD) compared with those revealed in patients with multiple system atrophy (MSA) or Parkinson's disease (PD) and in normal controls. METHODS: Twenty-two patients with iRBD, 21 patients with MSA, 22 patients with PD and 21 normal controls were included in this study. All participants underwent one night of video-polysomnography (PSG) monitoring, and the sleep parameters were analyzed using Polysmith software and by visual analysis...
November 29, 2016: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/27888722/a-pilot-study-on-predictors-of-brainstem-raphe-abnormality-in-patients-with-major-depressive-disorder
#7
Milutin Kostić, Ana Munjiza, Danilo Pesic, Amir Peljto, Ivana Novakovic, Valerija Dobricic, Dusica Lecic Tosevski, Milija Mijajlovic
BACKGROUND: Hypo/anechogenicity of the brainstem raphe (BR) structures has been suggested as a possible transcranial parenchymal sonography (TCS) marker associated with depression. AIM: The aim of this study was to analyze possible association of the abnormal BR echogenicity in patients with major depression when compared to healthy controls, and to evaluate its clinical and genetic correlates. METHODS: TCS was performed in 53 patients diagnosed as major depressive disorder (MDD) without psychotic symptoms and in 54 healthy matched controls...
November 22, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27873319/lung-neuroendocrine-tumours-deep-sequencing-of-the-four-who-histotypes-reveals-chromatin-remodelling-genes-as-major-players-and-a-prognostic-role-for-tert-rb1-men1-and-kmt2d
#8
Michele Simbolo, Andrea Mafficini, Katarzyna O Sikora, Matteo Fassan, Stefano Barbi, Vincenzo Corbo, Luca Mastracci, Borislav Rusev, Federica Grillo, Caterina Vicentini, Roberto Ferrara, Sara Pilotto, Federico Davini, Giuseppe Pelosi, Rita T Lawlor, Marco Chilosi, Giampaolo Tortora, Emilio Bria, Gabriella Fontanini, Marco Volante, Aldo Scarpa
Next-generation sequencing (NGS) was applied to 148 lung neuroendocrine tumours (LNET) comprising the 4 WHO classification categories: 53 typical carcinoid (TC), 35 atypical carcinoid (AC), 27 large cell neuroendocrine carcinoma (LCNEC), and 33 small cell lung carcinoma (SCLC). A discovery screen was conducted on 46 samples using whole-exome sequencing and high-coverage targeted sequencing of 418 genes. Eighty-eight recurrently mutated genes from both the discovery screen and current literature were verified in the 46 cases of the discovery screen and validated on additional 102 LNET by targeted NGS, and their prevalence was evaluated on the whole series...
November 22, 2016: Journal of Pathology
https://www.readbyqxmd.com/read/27870788/prenatal-ultrasound-evaluation-of-the-position-of-conus-medullaris-for-the-diagnosis-of-tethered-cord-syndrome
#9
Shao-Zheng He, Guo-Rong Lv, Shun-Lan Liu, Jun-Xian Ruan
To determine the conus distance between the end of the conus medullaris and the distal end of the last vertebral body in healthy fetuses with various gestational ages using ultrasonography for its diagnostic value in tethered cord syndrome (TCS). This retrospective study included 540 healthy and 8 autopsy-confirmed TCS fetuses. Ultrasonographic measurement of the conus distance was performed when the fetus was in a prone position within the spine in the near field at 14 to 41 weeks of gestational age. Linear correlation analysis was performed to analyze the relationship between the conus distance and the gestational age, biparietal diameter, femur length, head circumference, and abdominal circumference...
December 2016: Ultrasound Quarterly
https://www.readbyqxmd.com/read/27864760/imaging-tcsn-gfp-a-synthetic-cytokinin-reporter-in-arabidopsis-thaliana
#10
Jingchun Liu, Bruno Müller
Cytokinins are classical plant hormones that control numerous developmental processes throughout the plant life cycle. Cytokinin-responsive cells activate transcription via a phospho-relay signaling network. Type-B nuclear RESPONSE REGULATOR (RR) proteins mediate transcriptional activation as the final step in the signaling cascade. They bind to promoters of immediate-early target genes via a conserved Myb-related DNA-binding domain. To monitor transcriptional activation in response to a cytokinin stimulus, we have constructed a synthetic promoter, TCS (two-component signaling sensor) that harbors the concatemerized binding motifs for activated type-B RR in an optimized configuration...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27862766/terpene-cyclases-from-social-amoebae
#11
Patrick Rabe, Jan Rinkel, Britta Nubbemeyer, Tobias G Köllner, Feng Chen, Jeroen S Dickschat
Genome sequences of social amoebae reveal the presence of terpene cyclases (TCs) in these organisms. Two TCs from Dictyostelium discoideum converted farnesyl diphosphate into (2S,3R,6S,9S)-(-)-protoillud-7-ene and (3S)-(+)-asterisca-2(9),6-diene. The enzyme mechanisms and EI-MS fragmentations of the products were studied by labeling experiments.
November 10, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27861396/surgical-treatments-on-adult-tethered-cord-syndrome-a-retrospective-study
#12
Jun Gao, Xiangyi Kong, Zhimin Li, Tianyu Wang, Yongning Li
To investigate effects of surgical treatment on adult tethered cord syndrome (TCS).A retrospective analysis of 82 adult patients (17 male cases, 82% and 24 female cases, 59%) with TCS treated by surgery was conducted between March, 2005 and December, 2015, with an average age of 31.6 years and average disease course of 6.7 years. All the 82 cases of patients received nerve electrophysiology monitoring assisted microsurgery. After surgery, all patients were followed up for an average of 2.5 years. Surgical effects were evaluated according to Hoffman grading system...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27860334/maintenance-therapy-with-everolimus-for-subependymal-giant-cell-astrocytoma-in-patients-with-tuberous-sclerosis-the-eminents-study
#13
Joanna Trelinska, Iwona Dachowska, Dobromila Baranska, Konrad Stawiski, Katarzyna Kotulska, Wojciech Fendler, Sergiusz Jozwiak, Wojciech Mlynarski
OBJECTIVE: One of the therapeutic options for patients with tuberous sclerosis (TCS) and subependymal giant cell astrocytoma (SEGA) is everolimus treatment once daily, every day, to attain trough concentrations of 5-15 ng/ml (standard treatment). The aim of this study was to evaluate the efficacy and safety of a reduced dose of everolimus (three times a week with a daily dose as in standard treatment-maintenance therapy) in a group of patients who were previously treated with standard dose for at least 12 months...
November 15, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27860245/telocytes-a-potential-defender-in-the-spleen-of-npc1-mutant-mice
#14
Bichao Zhang, Ciqing Yang, Liang Qiao, Qiuling Li, Congrui Wang, Xin Yan, Juntang Lin
Niemann-Pick disease, type C1 (Npc1), is an atypical lysosomal storage disorder caused by autosomal recessive inheritance of mutations in Npc1 gene. In the Npc1 mutant mice (Npc1(-/-) ), the initial manifestation is enlarged spleen, concomitant with free cholesterol accumulation. Telocytes (TCs), a novel type of interstitial cell, exist in a variety of tissues including spleen, presumably thought to be involved in many biological processes such as nursing stem cells and recruiting inflammatory cells. In this study, we found that the spleen is significantly enlarged in Npc1(-/-) mice, and the results from transmission electron microscopy examination and immunostaining using three different TCs markers, c-Kit, CD34 and Vimentin revealed significantly increased splenic TCs in Npc1(-/-) mice...
November 18, 2016: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/27857154/a-van-der-waals-like-transition-between-normal-and-cancerous-phases-in-cell-populations-dynamics-of-colorectal-cancer
#15
Kang Qiu, Li-Fang Wang, Jian Shen, Alssadig A M Yousif, Peng He, Dan-Dan Shao, Xiao-Min Zhang, John B Kirunda, Ya Jia
Based on a deterministic continuous model of cell populations dynamics in the colonic crypt and in colorectal cancer, we propose four combinations of feedback mechanisms in the differentiations from stem cells (SCs) to transit cells (TCs) and then to differentiated cells (DCs), the four combinations include the double linear (LL), the linear and saturating (LS), the saturating and linear (SL), and the double saturating (SS) feedbacks, respectively. The relative fluctuations of the population of SCs, TCs, and DCs around equilibrium states with four feedback mechanisms are studied by using the Langevin method...
November 18, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27853259/comparative-transcriptome-analysis-of-chinary-assamica-and-cambod-tea-camellia-sinensis-types-during-development-and-seasonal-variation-using-rna-seq-technology
#16
Ajay Kumar, Vandna Chawla, Eshita Sharma, Pallavi Mahajan, Ravi Shankar, Sudesh Kumar Yadav
Tea quality and yield is influenced by various factors including developmental tissue, seasonal variation and cultivar type. Here, the molecular basis of these factors was investigated in three tea cultivars namely, Him Sphurti (H), TV23 (T), and UPASI-9 (U) using RNA-seq. Seasonal variation in these cultivars was studied during active (A), mid-dormant (MD), dormant (D) and mid-active (MA) stages in two developmental tissues viz. young and old leaf. Development appears to affect gene expression more than the seasonal variation and cultivar types...
November 17, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27852773/early-odorant-exposure-increases-the-number-of-mitral-and-tufted-cells-associated-with-a-single-glomerulus
#17
Annie Liu, Sajishnu Savya, Nathaniel N Urban
: The highly specific organization of the olfactory bulb (OB) is well known, but the impact of early odorant experience on its circuit structure is unclear. Olfactory sensory neurons (OSNs) project axons from the olfactory epithelium to the OB, where they form spherical neuropil structures called glomeruli. These glomeruli and the postsynaptic targets of OSNs, including mitral and tufted cells (M/TCs) and juxtaglomerular cells, form glomerular modules, which represent the basic odor-coding units of the OB...
November 16, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27851656/does-otosclerosis-affect-dark-and-transitional-cells-in-the-human-vestibular-labyrinth
#18
Serdar Kaya, Michael M Paparella, Sebahattin Cureoglu
HYPOTHESIS: The density of vestibular dark cells (DCs) and vestibular transitional cells (TCs) can be quantitatively decreased in human temporal bones with otosclerosis. BACKGROUND: Previous reports have shown that otosclerosis can lead to vestibular symptoms. METHODS: We examined 61 human temporal bone specimens from 52 deceased donors with otosclerosis group-with and without endosteal involvement (EI), and with and without endolymphatic hydrops (EH)-versus 25 specimens from 18 age-matched controls...
November 15, 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27845335/an-iron-detection-system-determines-bacterial-swarming-initiation-and-biofilm-formation
#19
Chuan-Sheng Lin, Yu-Huan Tsai, Chih-Jung Chang, Shun-Fu Tseng, Tsung-Ru Wu, Chia-Chen Lu, Ting-Shu Wu, Jang-Jih Lu, Jim-Tong Horng, Jan Martel, David M Ojcius, Hsin-Chih Lai, John D Young
Iron availability affects swarming and biofilm formation in various bacterial species. However, how bacteria sense iron and coordinate swarming and biofilm formation remains unclear. Using Serratia marcescens as a model organism, we identify here a stage-specific iron-regulatory machinery comprising a two-component system (TCS) and the TCS-regulated iron chelator 2-isocyano-6,7-dihydroxycoumarin (ICDH-Coumarin) that directly senses and modulates environmental ferric iron (Fe(3+)) availability to determine swarming initiation and biofilm formation...
November 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27842719/laccase-and-electrochemically-mediated-conversion-of-triclosan-metabolite-formation-and-influence-on-antibacterial-activity
#20
Elham Jahangiri, Bettina Seiwert, Thorsten Reemtsma, Dietmar Schlosser
Metabolite formation from radical-based oxidation of the environmental pollutant triclosan (TCS) was compared using an ascomycete (Phoma sp. UHH 5-1-03) and a basidiomycete (Trametes versicolor) laccase, laccase-redox mediator systems, and electrochemical oxidation (EC). Laccase oxidation predominantly yielded TCS di- and trimers, but notably also caused TCS ether bond cleavage. The latter was more prominent during EC-catalysed TCS oxidation, which generally resulted in a broader and more divergent product spectrum...
November 11, 2016: Chemosphere
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