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https://www.readbyqxmd.com/read/28453554/prognostic-value-of-pd-l1-expression-in-tumor-infiltrating-immune-cells-in-cancers-a-meta-analysis
#1
Tiancheng Zhao, Changfeng Li, Yanhua Wu, Bingjin Li, Bin Zhang
Programmed death-ligand 1 (PD-L1) is a promising target of cancer immune therapy. It not only expressed in tumor cells (TCs) but also up regulated in tumor infiltrating immune cells (TIICs). Although the previous meta-analysis have shown that PD-L1 expression in TCs was a valuable biomarker in predicting cancer prognosis, but few researches systematic evaluated the association between its expression in TIICs and survival of cancer patients. Thus, we performed this meta-analysis to evaluate the prognostic value of PD-L1 expression in TIICs in different types of cancers...
2017: PloS One
https://www.readbyqxmd.com/read/28449226/an-integrated-network-analysis-identifies-how-arcab-enables-metabolic-oscillations-in-the-nitric-oxide-detoxification-network-of-escherichia-coli
#2
Sarah A Sacco, Kristin J Adolfsen, Mark P Brynildsen
The virulences of many pathogens depend on their abilities to detoxify the immune antimicrobial nitric oxide (NO•). The functions of bacterial NO• detoxification machinery depend on oxygen (O2 ), with O2 inhibiting some enzymes, whereas others use it as a substrate. Previously, Escherichia coli NO• detoxification was found to be highly attenuated under microaerobic conditions and metabolic oscillations were observed. The oscillations in [NO•] and [O2 ] were found to result from the inhibitory action of NO• on aerobic respiration, the catalytic inactivation of NO• by Hmp (an NO• dioxygenase), and an imbalanced competition for O2 between Hmp and cytochrome terminal oxidase activity...
April 27, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/28446756/a-chemically-patterned-microfluidic-paper-based-analytical-device-c-%C3%A2%C2%B5pad-for-point-of-care-diagnostics
#3
Trinh Lam, Jasmine P Devadhasan, Ryan Howse, Jungkyu Kim
A chemically patterned microfluidic paper-based analytical device (C-µPAD) is developed to create fluidic networks by forming hydrophobic barriers using chemical vapor deposition (CVD) of trichlorosilane (TCS) on a chromatography paper. By controlling temperature, pattern size, and CVD duration, optimal conditions were determined by characterizing hydrophobicity, spreading patterns, and flow behavior on various sized fluidic patterns. With these optimal conditions, we demonstrated glucose assay, immunoassay, and heavy metal detection on well-spot C-µPAD and lateral flow C-µPAD...
April 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28441986/medical-therapy-versus-dietary-avoidance-in-eosinophilic-esophagitis-which-approach-is-better
#4
Mirna Chehade, Ellen Sher
BACKGROUND: Eosinophilic esophagitis (EoE) is a chronic immune-mediated esophageal disease characterized by esophageal symptoms and esophageal eosinophilia. It is induced by food triggers and by environmental allergens in some patients. No U.S. Food and Drug Administration approved therapies exist for patients with EoE. Common therapies include topical corticosteroids (TCS) and dietary restriction. METHODS: This article reviewed the pros and cons of a medical versus dietary approach in treating EoE in children and adults...
May 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28441105/transcriptomic-dissection-of-the-horizontally-acquired-response-regulator-esrb-reveals-its-global-regulatory-roles-in-the-physiological-adaptation-and-activation-of-t3ss-and-the-cognate-effector-repertoire-in-edwardsiella-piscicida-during-infection-towards
#5
Yang Liu, Luyao Zhao, Minjun Yang, Kaiyu Yin, Xiaohui Zhou, Ka Yin Leung, Qin Liu, Yuanxing Zhang, Qiyao Wang
Edwardsiella piscicida is the leading pathogen threatening worldwide aquaculture industries. The two-component system (TCS) EsrA-EsrB is essential for the pathogenesis of this bacterium. However, little is known about the regulon and regulatory mechanism of EsrA-EsrB or about the factors that mediate the interaction of TCS with bacterial hosts. Here, our RNA-seq analysis indicated that EsrB strongly induces type III and type VI secretion systems (T3/T6SS) expression and that it modulates the expression of both physiology- and virulence-associated genes in E...
April 25, 2017: Virulence
https://www.readbyqxmd.com/read/28439896/topical-corticosteroid-phobia-in-atopic-dermatitis-international-feasibility-study-of-the-topicop-score
#6
Jean-Francois Stalder, Hélène Aubert, Emmanuelle Anthoine, Leila Moret, Sebastien Barbarot, Masaki Futamura, Danielle Marcoux, Marie-Anne Morren, Magdalena Trzeciak, Zsuzsanna Szalai, Klára Veres, Mette Deleuran, Christian Vestergaard, Franck Boralevi, Chua-Yu Chu, Linda De Raeve, Åke Svensson, Regina Fölster-Holst, Matthias Buchner, Roberto Takaoka, Valeria Aoki, Pavel Chernyshov, Luidmyla Chernyshova, Dedee F Murrell, Cathy Zhao, Carola Duran Mckinster, Laura Von Kobyletzky, Laurence Eichenfield, Christine Totri, Peter Lio, Julien Seneschal
BACKGROUND: Adherence to topical corticosteroids (TCS) is essential for the effective treatment of atopic dermatitis but can be limited by concerns about their use. This study examined the feasibility of applying the validated TOPICOP score for assessing TCS phobia across different countries. METHODS: This was a prospective multicenter feasibility study conducted in 21 hospitals in 17 countries. Patients >3 months of age with atopic dermatitis or their parents or legal representatives completed a validated translation of the TOPICOP questionnaire in the country's native language...
April 25, 2017: Allergy
https://www.readbyqxmd.com/read/28437600/how-are-behavioral-theories-used-in-interventions-to-promote-physical-activity-in-rheumatoid-arthritis-a-systematic-review
#7
Ingrid Demmelmaier, Maura D Iversen
OBJECTIVES: To identify the use of behavioral theories (BTs) in physical activity (PA) interventions in populations with RA. METHODS: This review includes articles published in English between 01-01-1980 and 08-12-2015 in MEDLINE, Cochrane and CINAHL identified by a strategic literature search. Included studies were: published in international peer-reviewed journals; mentioned "theory", evaluated a PA intervention for adults with RA; and had ≥ 1 PA variable as the outcome...
April 24, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28437463/relationship-of-the-crebc-two-component-regulatory-system-and-inner-membrane-protein-cred-with-swimming-motility-in-stenotrophomonas-maltophilia
#8
Hsin-Hui Huang, Wei-Ching Chen, Cheng-Wen Lin, Yi-Tsung Lin, Hsiao-Chen Ning, Yi-Chih Chang, Tsuey-Ching Yang
The CreBC two-component system (TCS) is a conserved regulatory system found in Escherichia coli, Aeromonas spp., Pseudomonas aeruginosa, and Stenotrophomonas maltophilia. In this study, we determined how CreBC TCS regulates secreted protease activities and swimming motility using creB, creC, and creBC in-frame deletion mutants (KJΔCreB, KJΔCreC, and KJΔBC) of S. maltophilia KJ. Compared to wild-type KJ, KJΔCreB had a comparable secreted protease activity; however, the secreted protease activities were obviously reduced in KJΔCreC and KJΔBC, suggesting that CreC works together with another unidentified response regulator (not CreB) to regulate secreted protease activity...
2017: PloS One
https://www.readbyqxmd.com/read/28436085/effect-of-triclosan-on-anuran-development-and-growth-in-a-larval-amphibian-growth-and-development-assay
#9
Douglas J Fort, Michael B Mathis, Sascha Pawlowski, Jeffrey C Wolf, Robert Peter, Samantha Champ
A larval amphibian growth and development assay was performed to evaluate the potential effects of environmentally-relevant concentrations of triclosan (TCS) on amphibian development and growth. Xenopus laevis were exposed to TCS 0.0 (control), 6.3, 12.5 and 25.0 μg l(-1) (estimated maximum tolerable concentration) until 10 weeks post-metamorphosis. At median metamorphosis time (Nieuwkoop and Faber stage 62), five larvae per replicate were collected for snout-vent length, hind limb length and body weight measurements, and histopathological examination of thyroid glands...
April 24, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28422907/adequacy-and-accuracy-of-non-trauma-center-computed-tomography-what-are-we-missing
#10
Morgan Bonds, Stephen Hersperger, Tabitha Garwe, Robert Fails, Sigrid Johannesen, Christina Kim, Ademola A Adeseye, Jason Lees, William Havron
BACKGROUND: Timely and appropriate use of computed tomography (CT) scans is critical to the evaluation of traumatic injuries. The objective of this study was to assess the adequacy of CT scans performed at non-trauma centers (NTCs) as they pertain to the management of trauma patients. METHODS: Adult patients transferred to our ACS-verified level 1 trauma center from any NTC between May and December 2012 were enrolled prospectively. Available CT images from NTCs were reviewed in a blinded fashion by our facility's trauma radiologist; his interpretations were compared with those from the NTC...
April 18, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28418360/-role-of-telocytes-in-the-heart-in-health-and-diseases
#11
Yu V Liskova, A A Stadnikov, S P Salikova
This review summarizes the data available in the literature on the development, structure, and function of telocytes (TCs) and their role in the heart in health and diseases. At the present time, TCs have been found in many organs of mammals and humans. TC is a small oval cell that contains a nucleus surrounded by small amounts of cytoplasm, with extremely long and thin processes named telopodias. TCs have unique ultrastructural and immunohistochemical features; double positive labeling for CD34/PDGFR-β and CD34/vimentin is suitable for their identification...
2017: Arkhiv Patologii
https://www.readbyqxmd.com/read/28414947/application-of-pyrolysis-to-recycling-organics-from-waste-tantalum-capacitors
#12
Bo Niu, Zhenyang Chen, Zhenming Xu
Tantalum capacitors (TCs) are widely used in electronic appliances. The rapid replacement of electronic products results in generating large amounts of waste TCs (WTCs). WTCs, rich in valuable tantalum, are considered as high quality tantalum resources for recycling. However, environmental pollution will be caused if the organics of WTCs were not properly disposed. Therefore, effectively recycling the organics of WTCs is significant for recovering the valuable parts. This study proposed an argon (Ar) pyrolysis process to recycle the organics from WTCs...
April 9, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28410490/survival-of-86-690-patients-with-thyroid-cancer-a-population-based-study-in-29-european-countries-from-eurocare-5
#13
L Dal Maso, A Tavilla, F Pacini, D Serraino, B A C van Dijk, M D Chirlaque, R Capocaccia, N Larrañaga, M Colonna, D Agius, E Ardanaz, J Rubió-Casadevall, A Kowalska, S Virdone, S Mallone, H Amash, R De Angelis
BACKGROUND: Incidence rates of thyroid cancer (TC) increased in several countries during the last 30 years, while mortality rates remained unchanged, raising important questions for treatment and follow-up of TC patients. This study updates population-based estimates of relative survival (RS) after TC diagnosis in Europe by sex, country, age, period and histology. METHODS: Data from 87 cancer registries in 29 countries were extracted from the EUROCARE-5 dataset...
April 11, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28400017/screening-of-the-two-component-system-histidine-kinases-of-listeria-monocytogenes-egd-e-lias-is-needed-for-growth-under-heat-acid-alkali-osmotic-ethanol-and-oxidative-stresses
#14
Anna Pöntinen, Miia Lindström, Mikael Skurnik, Hannu Korkeala
To study the role of each two-component system (TCS) histidine kinase (HK) in stress tolerance of Listeria monocytogenes EGD-e, we monitored the growth of individual HK deletion mutant strains under heat (42.5 °C), acid (pH 5.6), alkali (pH 9.4), osmotic (6% NaCl), ethanol (3.5 vol%), and oxidative (5 mM H2O2) stresses. The growth of ΔliaS (Δlmo1021) strain was impaired under each stress, with the most notable decrease under heat and osmotic stresses. The ΔvirS (Δlmo1741) strain showed nearly completely restricted growth at high temperature and impaired growth in ethanol...
August 2017: Food Microbiology
https://www.readbyqxmd.com/read/28399780/triclosan-coated-sutures-for-the-prevention-of-surgical-site-infections-a-meta-analysis
#15
Athanasios A Konstantelias, Chrysi Stefania I Andriakopoulou, Sofia Mourgela
BACKGROUND: The scope of this article is to perform a meta-analysis of the studies that compare the use of triclosan-coated sutures (TCS) to uncoated sutures in prevention of surgical-site infections (SSIs). METHODS: A systematic search of randomized and non-randomized studies was carried out on Pubmed and Scopus databases until July 2016. RESULTS: The meta-analysis of 30 studies (19 randomized, 11 non-randomized; 15,385 procedures) gave evidence that TCS were associated with a lower risk of SSIs (risk ratio [RR] = 0...
June 2017: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/28399280/evaluation-of-the-select-tick-control-system-tcs-a-host-targeted-bait-box-to-reduce-exposure-to-ixodes-scapularis-acari-ixodidae-in-a-lyme-disease-endemic-area-of-new-jersey
#16
Terry L Schulze, Robert A Jordan, Martin Williams, Marc C Dolan
We describe a 2-yr trial to evaluate the ability of SELECT Tick Control System (TCS) host-targeted bait boxes to reduce numbers of host-seeking Ixodes scapularis nymphs in a residential neighborhood. After four successive 9-wk deployments, nymphal and larval I. scapularis infestation prevalence and intensity were significantly reduced on target small mammals. In addition, these deployments resulted in 87.9% and 97.3% control of host-seeking nymphs in treatment sites at 1 yr and 2 yr postintervention, respectively...
March 15, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28396479/heterogeneities-in-the-case-fatality-ratio-in-the-west-african-ebola-outbreak-2013-2016
#17
Tini Garske, Anne Cori, Archchun Ariyarajah, Isobel M Blake, Ilaria Dorigatti, Tim Eckmanns, Christophe Fraser, Wes Hinsley, Thibaut Jombart, Harriet L Mills, Gemma Nedjati-Gilani, Emily Newton, Pierre Nouvellet, Devin Perkins, Steven Riley, Dirk Schumacher, Anita Shah, Maria D Van Kerkhove, Christopher Dye, Neil M Ferguson, Christl A Donnelly
The 2013-2016 Ebola outbreak in West Africa is the largest on record with 28 616 confirmed, probable and suspected cases and 11 310 deaths officially recorded by 10 June 2016, the true burden probably considerably higher. The case fatality ratio (CFR: proportion of cases that are fatal) is a key indicator of disease severity useful for gauging the appropriate public health response and for evaluating treatment benefits, if estimated accurately. We analysed individual-level clinical outcome data from Guinea, Liberia and Sierra Leone officially reported to the World Health Organization...
May 26, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28392556/role-of-orexin-a-in-the-ventrolateral-preoptic-area-on-components-of-total-energy-expenditure
#18
J E Coborn, D P DePorter, V Mavanji, C M Sinton, C M Kotz, C J Billington, J A Teske
BACKGROUND: Identifying whether components of total EE are affected by orexin receptor (OXR1 and OXR2) stimulation or antagonism with dual orexin receptor antagonists (DORAs) has relevance for obesity treatment. Orexin receptor stimulation reduces weight gain by increasing total energy expenditure (EE) and EE during spontaneous physical activity (SPA). OBJECTIVE: The purpose of this study was to determine if a DORA (TCS-1102) in the ventrolateral preoptic area (VLPO) reduced orexin-A-induced arousal, SPA, total EE and EE during sleep, rest, wake and SPA and whether the DORA alone reduced total EE and its components...
April 10, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28388675/impact-of-mca-stenosis-on-the-early-outcome-in-acute-ischemic-stroke-patients
#19
Jiann-Shing Jeng, Fang-I Hsieh, Hsu-Ling Yeh, Wei-Hung Chen, Hou-Chang Chiu, Sung-Chun Tang, Chung-Hsiang Liu, Huey-Juan Lin, Shih-Pin Hsu, Yuk-Keung Lo, Lung Chan, Chih-Hung Chen, Ruey-Tay Lin, Yu-Wei Chen, Jiunn-Tay Lee, Chung-Hsin Yeh, Ming-Hui Sun, Ta-Chang Lai, Yu Sun, Mu-Chien Sun, Po-Lin Chen, Tsuey-Ru Chiang, Shinn-Kuang Lin, Bak-Sau Yip, Chin-I Chen, Chi-Huey Bai, Sien-Tsong Chen, Hung-Yi Chiou, Li-Ming Lien, Chung Y Hsu
BACKGROUND: Asians have higher frequency of intracranial arterial stenosis. The present study aimed to compare the clinical features and outcomes of ischemic stroke patients with and without middle cerebral artery (MCA) stenosis, assessed by transcranial sonography (TCS), based on the Taiwan Stroke Registry (TSR). METHODS: Patients with acute ischemic stroke or transient ischemic attack registered in the TSR, and received both carotid duplex and TCS assessment were categorized into those with stenosis (≥50%) and without (<50%) in the extracranial internal carotid artery (ICA) and MCA, respectively...
2017: PloS One
https://www.readbyqxmd.com/read/28386771/potential-neoplastic-evolution-of-vero-cells-in-vivo-and-in-vitro-characterization
#20
N A Andreani, S Renzi, G Piovani, P Ajmone Marsan, L Bomba, R Villa, M Ferrari, S Dotti
Vero cell lines are extensively employed in viral vaccine manufacturing. Similarly to all established cells, mutations can occur during Vero cells in vitro amplification which can result in adverse features compromising their biological safety. To evaluate the potential neoplastic evolution of these cells, in vitro transformation test, gene expression analysis and karyotyping were compared among low- (127 and 139 passages) and high-passage (passage 194) cell lines, as well as transformed colonies (TCs). In vivo tumorigenicity was also tested to confirm preliminary in vitro data obtained for low passage lines and TCs...
April 6, 2017: Cytotechnology
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