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https://www.readbyqxmd.com/read/28213709/high-efficiency-removal-of-triclosan-by-structure-directing-agent-modified-mesoporous-mil-53-al
#1
Rongni Dou, Junya Zhang, Yuancai Chen, Siyuan Feng
In order to expand the potential applications of metal-organic frameworks (MOFs), structure directing agents modified mesoporous MIL-53(Al) (MIL-53(Al)-1) was investigated to adsorb triclosan (TCS) with two different initial concentrations. MIL-53(Al)-1 with high mesoporosity and total pore volume exhibited higher adsorption capacity and 4.4 times faster adsorption of TCS at low concentration (1 mg L(-1)) than that of microporous MIL-53(Al). Also, mesoporous as well as microporous MIL-53(Al) showed significant higher adsorption capacity and two orders of magnitude greater fast uptake of TCS than two kinds of mesoporous-activated carbon...
February 18, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28208874/topical-corticosteroid-misuse-the-scenario-in-patients-attending-a-tertiary-care-hospital-in-new-delhi
#2
Santwana Mahar, Khushbu Mahajan, Swati Agarwal, Hemanta Kumar Kar, Swapan Kumar Bhattacharya
INTRODUCTION: Irrational use of Topical Corticosteroid (TC) is quite common in India due to unrestricted availability and use of TC not only by general public but also by physicians and chemists due to quick relief of symptoms in different dermatological conditions. AIM: The present study was conducted to evaluate and analyse the prevalence of misuse of TC and the causes behind misuse of TC among patients in a dermatology outpatient department in New Delhi. MATERIALS AND METHODS: This was a cross-sectional observational questionnaire based study conducted over a period of 5 months (1(st) June 2015 to 30(th) November 2015)...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28195101/trichoblastic-carcinoma-of-the-scalp-with-rippled-pattern
#3
Cem Leblebici, Dincer Altinel, Merdan Serin, Oguzhan Okcu, Sevgi Kurt Yazar
Trichoblastic carcinoma (TC) is a rare type of malignancy which is derived from the hair follicles. In this paper, we report a case with TC on the scalp characterized with rippled pattern. There have been reports of rippled pattern in trichoblastomas, sebaceomas, and basal cell carcinomas. To the best of our knowledge, this is the first case in the literature to report a rippled pattern in TCs.
January 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28193322/geographic-distribution-of-trauma-burden-mortality-and-services-in-the-united-states-does-availability-correspond-to-patient-need
#4
Arturo J Rios-Diaz, David Metcalfe, Olubode A Olufajo, Cheryl K Zogg, Brian Yorkgitis, Mansher Singh, Adil H Haider, Ali Salim
BACKGROUND: The association between the need for trauma care and trauma services has not been characterized previously. We compared the distribution of trauma admissions with state-level availability of trauma centers (TCs), surgical critical care (SCC) providers, and SCC fellowships, and assessed the association between trauma care provision and state-level trauma mortality. STUDY DESIGN: We obtained 2013 state-level data on trauma admissions, TCs, SCC providers, SCC fellowship positions, per-capita income, population size, and age-adjusted mortality rates...
December 2016: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28181094/factors-predicting-patient-s-allocation-to-short-and-long-term-therapeutic-community-treatments-in-the-italian-voect-cohort-study
#5
F Vigna-Taglianti, F Mathis, R Diecidue, E Trogu, U Kirchmayer, J Ghibaudi, G Piras, A Camposeragna, A Saponaro, L Amato, M Davoli, F Faggiano, P P Pani
The Evaluation of Therapeutic Community Treatments and Outcomes (VOECT) study was conducted in 131 Italian Therapeutic Communities (TCs) in 2008/2009. All of the patients entering residential treatment for drug or alcohol dependence were invited to participate. Data regarding patient socio-demographic characteristics, drug and alcohol consumption, health and psychopathological status, prior treatments and outcomes, and their motivation score were collected upon enrolment onto the study. The aim of this work was to identify the factors associated with allocation to short- versus long-term programmes in drug or alcohol dependent patients entering TCs in Italy...
February 8, 2017: Community Mental Health Journal
https://www.readbyqxmd.com/read/28178095/clubfoot-and-tethered-cord-syndrome-results-of-treatment-with-the-ponseti-method
#6
Trevor Jackson, Alexander Jones, Nancy Miller, Gaia Georgopoulos
BACKGROUND: The Ponseti technique has demonstrated high success rates worldwide for the treatment of idiopathic clubfoot. The purpose of this study was to determine whether clubfoot associated with tethered cord syndrome (TCS) was more resistant to Ponseti treatment than isolated clubfoot. METHODS: An IRB-approved retrospective cohort study of subjects undergoing Ponseti treatment of clubfoot between 2002 and 2013 was conducted. Subjects with TCS were matched to subjects with isolated clubfoot (1:2) on the basis of laterality, date of birth, sex, and age at presentation...
February 7, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28167784/bordetella-plrsr-regulatory-system-controls-bvgas-activity-and-virulence-in-the-lower-respiratory-tract
#7
M Ashley Bone, Aaron J Wilk, Andrew I Perault, Sara A Marlatt, Erich V Scheller, Rebecca Anthouard, Qing Chen, Scott Stibitz, Peggy A Cotter, Steven M Julio
Bacterial pathogens coordinate virulence using two-component regulatory systems (TCS). The Bordetella virulence gene (BvgAS) phosphorelay-type TCS controls expression of all known protein virulence factor-encoding genes and is considered the "master virulence regulator" in Bordetella pertussis, the causal agent of pertussis, and related organisms, including the broad host range pathogen Bordetella bronchiseptica We recently discovered an additional sensor kinase, PlrS [for persistence in the lower respiratory tract (LRT) sensor], which is required for B...
February 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28161650/uncertainties-in-calculated-correction-factors-for-true-coincidence-summing-tcs
#8
J Kastlander, L-E De Geer, S Jonsson, H Ramebäck
The aim of this work was to estimate the uncertainties in Monte Carlo calculated correction factors for true coincidence summing (TCS). In this work TCS-factors and their uncertainties were calculated for (134)Cs and then the corrected activities compared to empirical data. The study was carried out using a close-end coaxial p-type detector (Ø80mm×54.5mm, 80% relative efficiency) and a cylindrical glass fiber sample (Ø60mm×14mm). It was shown that the uncertainty in the calculated correction factor for the primary gamma ray was below 0...
January 31, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28154339/construction-of-a-photo-responsive-chimeric-histidine-kinase-in-escherichia-coli
#9
Mayuko Hori, Shyunsuke Oka, Yoshimi Sugie, Hokuto Ohtsuka, Hirofumi Aiba
Two-component signal transduction systems (TCS), that are also referred to as His to Asp phosphorelay systems, are involved in widespread cellular responses to diverse signals from bacteria to plants. Previously, we succeeded in reconstructing a cyanobacterial photo-perception system in Escherichia coli by employing a CcaS-CcaR two-component system from Nostoc punctiforme. In this study, we have added a photo-responsive ability to ArcB-ArcA (anoxic redox control) TCS of E. coli by fusing a cyanobacterial photoreceptor domain of CcaS with an intracellular histidine kinase (HK) domain of ArcB...
January 31, 2017: Journal of General and Applied Microbiology
https://www.readbyqxmd.com/read/28148952/assessing-current-and-future-freshwater-flood-risk-from-north-atlantic-tropical-cyclones-via-insurance-claims
#10
Jeffrey Czajkowski, Gabriele Villarini, Marilyn Montgomery, Erwann Michel-Kerjan, Radoslaw Goska
The most recent decades have witnessed record breaking losses associated with U.S. landfalling tropical cyclones (TCs). Flood-related damages represent a large portion of these losses, and although storm surge is typically the main focus in the media and of warnings, much of the TC flood losses are instead freshwater-driven, often extending far inland from the landfall locations. Despite this actuality, knowledge of TC freshwater flood risk is still limited. Here we provide for the first time a comprehensive assessment of the TC freshwater flood risk from the full set of all significant flood events associated with U...
February 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28145492/hypocretin-orexin-peptides-excite-rat-neuroendocrine-dopamine-neurons-through-orexin-2-receptor-mediated-activation-of-a-mixed-cation-current
#11
David J Lyons, Arash Hellysaz, Rachida Ammari, Christian Broberger
Hypocretin/Orexin (H/O) neurons of the lateral hypothalamus are compelling modulator candidates for the chronobiology of neuroendocrine output and, as a consequence, hormone release from the anterior pituitary. Here we investigate the effects of H/O peptides upon tuberoinfundibular dopamine (TIDA) neurons - cells which control, via inhibition, the pituitary secretion of prolactin. In whole cell recordings performed in male rat hypothalamic slices, application of H/O-A, as well as H/O-B, excited oscillating TIDA neurons, inducing a reversible depolarising switch from phasic to tonic discharge...
February 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28143796/clr4-specificity-and-catalytic-activity-beyond-h3k9-methylation
#12
Denis Kusevic, Srikanth Kudithipudi, Nahid Iglesias, Danesh Moazed, Albert Jeltsch
In fission yeast, the catalytic activity of the protein lysine methyltransferase (PKMT) Clr4, the sole homolog of the mammalian SUV39H1 and SUV39H2 enzymes, majorly contributes to the formation of heterochromatin. The enzyme introduces histone 3 lysine 9 (H3K9) di- and tri-methylation, a central heterochromatic histone modification, and later it was also found to methylate the Mlo3 protein, which has a role in heterochromatin formation as well. Herein, we have investigated the substrate specificity of Clr4 using custom made mutational scanning peptide arrays...
January 28, 2017: Biochimie
https://www.readbyqxmd.com/read/28141652/tracheal-cartilaginous-sleeve-in-syndromic-craniosynostosis-an-underrecognized-source-of-significant-morbidity-and-mortality
#13
Brent B Pickrell, Jesse D Meaike, Karina T Cañadas, Binoy M Chandy, Edward P Buchanan
Tracheal cartilaginous sleeve (TCS) is a rare and previously unrecognized source of morbidity and mortality in patients with certain craniosynostosis syndromes. There is a paucity of reporting on this airway anomaly, and the true incidence of TCS is largely unknown. The purpose of this study was to investigate the incidence of TCS among patients with syndromic craniosynostosis at our institution. Patients with syndromic craniosynostosis who underwent direct bronchoscopy and laryngoscopy were evaluated retrospectively by pediatric otolaryngologists for the presence of TCS and associated anomalies...
January 30, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28138910/spray-dried-thiolated-chitosan-coated-sodium-alginate-multilayer-microparticles-for-vaginal-hiv-microbicide-delivery
#14
Jianing Meng, Vivek Agrahari, Miezan J Ezoulin, Sudhaunshu S Purohit, Tao Zhang, Agostino Molteni, Daniel Dim, Nathan A Oyler, Bi-Botti C Youan
It is hypothesized that novel thiolated chitosan-coated multilayer microparticles (MPs) with enhanced drug loading are more mucoadhesive than uncoated MPs and safe in vivo for vaginal delivery of topical anti-HIV microbicide. Formulation optimization is achieved through a custom experimental design and the alginate (AG) MPs cores are prepared using the spray drying method. The optimal MPs are then coated with the thiolated chitosan (TCS) using a layer-by-layer method. The morphological analysis, in situ drug payload, in vitro drug release profile, and mucoadhesion potential of the MPs are carried out using scanning electron microscopy, solid-state (31)P NMR spectroscopy, UV spectroscopy, fluorescence imaging and periodic acid Schiff method, respectively...
January 30, 2017: AAPS Journal
https://www.readbyqxmd.com/read/28134638/a-morphological-classification-scheme-for-the-mandibular-hypoplasia-in-treacher-collins-syndrome
#15
Cassandra A Ligh, Jordan Swanson, Jason W Yu, Fares Samra, Scott P Bartlett, Jesse A Taylor
BACKGROUND: Mandibular hypoplasia is a hallmark of Treacher Collins syndrome (TCS), and its severity accounts for significant functional morbidity. The purpose of this study is to develop a mandibular classification scheme. METHODS: A classification scheme was designed based on three-dimensional computed tomography (3D-CT) scans to assess 3 characteristic features: degree of condylar hypoplasia, mandibular plane angle (condylion-gonion-menton), and degree of retrognathia (sella-nasion-B point angle)...
January 27, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28134343/asymmetric-response-of-tropical-cyclone-activity-to-global-warming-over-the-north-atlantic-and-western-north-pacific-from-cmip5-model-projections
#16
Doo-Sun R Park, Chang-Hoi Ho, Johnny C L Chan, Kyung-Ja Ha, Hyeong-Seog Kim, Jinwon Kim, Joo-Hong Kim
Recent improvements in the theoretical understanding of the relationship between tropical cyclones (TCs) and their large-scale environments have resulted in significant improvements in the skill for forecasting TC activity at daily and seasonal time-scales. However, future changes in TC activity under a warmer climate remain uncertain, particularly in terms of TC genesis locations and subsequent pathways. Applying a track-pattern-based statistical model to 22 Coupled Model Intercomparison Project Phase 5 (CMIP5) model runs for the historical period and the future period corresponding to the Representative Concentration Pathway 8...
January 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28131952/brucella-abortus-2308%C3%AE-nodv%C3%AE-nodw-double-mutant-is-highly-attenuated-and-confers-protection-against-wild-type-challenge-in-balb-c-mice
#17
Zhiqiang Li, Shuli Wang, Jinliang Zhang, Guangli Yang, Baodong Yuan, Jie Huang, Jincheng Han, Li Xi, Yanren Xiao, Chuangfu Chen, Hui Zhang
Brucellosis is an important zoonotic disease of worldwide distribution, which causes animal and human disease. However, the current Brucella abortus (B. abortus) vaccines (S19 and RB51) have several drawbacks, including residual virulence for animals and humans. Moreover, S19 cannot allow serological differentiation between infected and vaccinated animals. We constructed double deletion (ΔNodVΔNodW) mutant from virulent B. abortus 2308 (S2308) by deleting the genes encoding two-component regulatory system (TCS) in chromosome II in S2308...
January 25, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28130901/trauma-center-youth-violence-screening-and-brief-interventions-a-multisite-pilot-feasibility-study
#18
Donna M Kazemi, David G Jacobs, Sharon G Portwood, Laura Veach, Weihua Zhou, Melissa Johnson Hurley
Every day, 16 American youths between the ages of 10 and 24 years are murdered; 84% of these fatalities involve a firearm. Nearly half of traumatic youth deaths result from violence-related injuries. In 2013, 580,250 youth suffered nonfatal, assault-related injuries, necessitating emergency department treatment. The aim of this multisite pilot study was to examine the process, feasibility, and challenges of violence brief interventions (VBIs). The participants were youth between 15 and 25 years of age, at 2 major Level 1 trauma centers (TCs; TC1, TC2) in the Southeastern United States...
January 27, 2017: Violence and Victims
https://www.readbyqxmd.com/read/28126462/exploring-genetic-variation-in-haplotypes-of-the-filariasis-vector-culex-quinquefasciatus-diptera-culicidae-through-dna-barcoding
#19
Chithravel Vadivalagan, Pushparaj Karthika, Kadarkarai Murugan, Chellasamy Panneerselvam, Paola Del Serrone, Giovanni Benelli
Culex quinquefasciatus (Diptera: Culicidae) is a vector of many pathogens and parasites of humans, as well as domestic and wild animals. In urban and semi-urban Asian countries, Cx. quinquefasciatus is a main vector of nematodes causing lymphatic filariasis. In the African region, it vectors the Rift Valley fever virus, while in the USA it transmits West Nile, St. Louis encephalitis and Western equine encephalitis virus. In this study, DNA barcoding was used to explore the genetic variation of Cx. quinquefasciatus populations from 88 geographical regions...
January 23, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28123920/spinning-out-of-control-a-19-year-old-female-with-spinning-related-exertional-thigh-compartment-syndrome
#20
Daniel J Gould, Ido Badash, Sukgu Han, Alex K Wong
Thigh compartment syndrome (TCS) is a rare condition caused by high pressures within the fascial compartments of the thigh, impeding capillary flow and leading to decreased perfusion, tissue hypoxia, and necrosis. TCS is most frequently associated with trauma and anticoagulation but has also rarely been associated with exercise-related injury. We present the case of a 19-year-old female who reported painful swelling in her thighs and darkening of her urine after participating in a spinning class. On physical examination, the patient was found to have tight, painful thigh compartments with extreme tenderness on passive motion...
December 24, 2016: Curēus
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