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https://www.readbyqxmd.com/read/29342422/magnetic-mesoporous-molecularly-imprinted-polymers-based-on-surface-precipitation-polymerization-for-selective-enrichment-of-triclosan-and-triclocarban
#1
Xuemei Wang, Pengfei Huang, Xiaomin Ma, Xinzhen Du, Xiaoquan Lu
Novel magnetic mesoporous molecularly imprinted polymers (MMIPs) were prepared based on surface precipitation polymerization using Triclosan (TCS) as template and methacrylic acid as functional monomer. The synthesized MMIPs-TCS were applied to the adsorbent of magnetic solid-phase extraction (MSPE) coupled with HPLC for the enrichment and determination of TCS. The MMIPs-TCS were characterized by fourier-transform infrared spectrometry (FTIR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), N2 adsorption-desorption transmission, and vibrating sample magnetometry...
January 10, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29339416/exploring-the-almost-unknown-archaeal-two-component-systems
#2
Tino Krell
Two-component systems (TCS) exist in bacteria and archaea. In contrast to bacterial TCSs little information is available on their archaeal counterparts. In this issue Galperin and coworkers present a bioinformatics analysis of TCS genes from archaeal genome sequences. This study identified different aspects in which bacterial and archaeal TCS mediated signaling differ and forms a sound basis for the experimental design of studies to increase our knowledge on this poorly investigated protein family.
January 16, 2018: Journal of Bacteriology
https://www.readbyqxmd.com/read/29335327/gps-experiences-of-diagnosing-and-managing-childhood-eczema-a-qualitative-study-in-primary-care
#3
Emma Le Roux, Kingsley Powell, Jonathan P Banks, Matthew J Ridd
BACKGROUND: Eczema is common among children, and in the UK the majority are managed by GPs. The most common cause of poor disease control is incorrect use of topical treatments. There is a lack of research into the challenges faced by GPs in diagnosing and managing this condition. AIM: To explore the experiences of GPs in assessing and managing children with eczema. DESIGN AND SETTING: Qualitative study in primary care in England. METHOD: Semi-structured interviews with 15 GPs were audiorecorded, transcribed verbatim, and analysed thematically using the framework method...
January 15, 2018: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/29335167/fate-and-hazard-of-the-electrochemical-oxidation-of-triclosan-evaluation-of-polychlorodibenzo%C3%A2-p%C3%A2-dioxins-and-polychlorodibenzofurans-pcdd-fs-formation
#4
Claudia Solá-Gutiérrez, M Fresnedo San Román, Inmaculada Ortiz
Triclosan (TCS) is widely used as antiseptic or preservative in many personal care products (PCPs), such as cosmetics, hand wash, toothpaste and deodorant soaps, among others. It is characterized by acute toxicity, resistance to biodegradation, environmental persistence and relatively high lipophilicity. In order to protect the environment and natural resources from the negative effects of the discharge of polluted wastewater with TCS, the application of efficient remediation technologies able to degrade the pollutant to harmless levels becomes crucial...
January 12, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29332277/efficient-degradation-of-triclosan-by-an-endophytic-fungus-penicillium-oxalicum-b4
#5
Hao Tian, Yan Jun Ma, Wan Yi Li, Jian Wen Wang
Triclosan (TCS), a widely used antimicrobial and preservative agent, is an emerging contaminant in aqueous and soil environment. Microbial degradation of TCS has not been reported frequently because of its inhibition of microbe growth. To explore the new microbial resources for TCS biodegradation, fungal endophytes were isolated and screened for the degradation potential. The endophytic strain B4 isolated from Artemisia annua L. showed higher degradation efficiency and was identified as Penicillium oxalicum based on its morphology and ITS sequences of ribosomal DNA...
January 13, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29332148/occurrence-of-pharmaceuticals-and-personal-care-products-and-their-associated-environmental-risks-in-a-large-shallow-lake-in-north-china
#6
Panwei Zhang, Huaidong Zhou, Kun Li, Xiaohui Zhao, Qiaona Liu, Dongjiao Li, Gaofeng Zhao
Eighteen selected pharmaceuticals and personal care products (PPCPs), consisting of five non-antibiotic pharmaceuticals (N-APs), four sulfonamides (SAs), four tetracyclines (TCs), four macrolides (MCs), and one quinolone (QN) were detected in water, pore water, and sediment samples from Baiyangdian Lake, China. A total of 31 water samples and 29 sediment samples were collected in March 2017. Caffeine was detected with 100% frequency in surface water, pore water, and sediment samples. Carbamazepine was detected with 100% frequency in surface water and sediment samples...
January 13, 2018: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/29328083/topological-charge-measurement-of-concentric-oam-states-using-the-phase-shift-method
#7
Han Gao, Yanhua Han, Yan Li, Dezhi Zhu, Mingjian Sun, Siyuan Yu
We proposed a method to measure orbital angular momentum (OAM) states by using a multi-zone pure phase grating with the phase-shift technique. In free-space optical communication systems, the topological charges (TCs) of concentric OAM beams are usually detected for decoding, since the diameter of the OAM beam relates to the transmission distance. Two typical concentric OAM beams, concentric Laguerre-Gaussian beams and perfect vortex beams, were generated as incident beams, and the diffraction patterns can be separated by implementing a pure phase grating in the Fourier plane of a 4-f system...
January 1, 2018: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/29323457/impact-of-subchronic-exposure-to-triclosan-and-or-fluoride-on-estrogenic-activity-in-immature-female-rats-the-expression-pattern-of-calbindin-d9k-and-estrogen-receptor-%C3%AE-genes
#8
Yasmina M Abd-Elhakim, Amany T Mohammed, Haytham A Ali
This study explored the influence of triclosan (TCS) in the absence and presence of sodium fluoride (NaF) on estrogenic activity and thyroid function of adolescent female rats. The results indicated that the individual exposure to TCS evoked a significant decline in T3 and T4 but the levels of estradiol, FSH, and LH were significantly elevated beside marked up regulation of calbindin-D9k and estrogen α mRNA expression. On the other hand, the single exposure to NaF causes insignificant changes in thyroid hormones, but evoked a trend toward an increase in both estradiol and LH levels...
January 11, 2018: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/29321854/phylogenetic-relationships-and-phylogeography-of-relevant-lineages-within-the-complex-campanulaceae-family-in-macaronesia
#9
Tiago Menezes, Maria M Romeiras, Miguel M de Sequeira, Mónica Moura
Macaronesia has long been recognized as a natural model for studying evolutionary processes in plant diversification. Several studies have attempted to focus on single lineages, and few have covered the diversification of a family across all the archipelagos. We used a comprehensive sample to clarify the phylogenetic relationships and the biogeographic history of the Macaronesian Campanulaceae. Hypotheses related to the colonization of these archipelagos will be used to examine the diversification patterns of different lineages...
January 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29317196/protonophoric-action-of-triclosan-causes-calcium-efflux-from-mitochondria-plasma-membrane-depolarization-and-bursts-of-miniature-end-plate-potentials
#10
Lyudmila B Popova, Ekaterina S Nosikova, Elena A Kotova, Ekaterina O Tarasova, Pavel A Nazarov, Lyudmila S Khailova, Olga P Balezina, Yuri N Antonenko
The formerly widely used broad-spectrum biocide triclosan (TCS) has now become a subject of special concern due to its accumulation in the environment and emerging diverse toxicity. Despite the common opinion that TCS is an uncoupler of oxidative phosphorylation in mitochondria, there have been so far no studies of protonophoric activity of this biocide on artificial bilayer lipid membranes (BLM). Yet only few works have indicated the relationship between TCS impacts on mitochondria and nerve cell functioning...
January 6, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29316326/orthopedia-homeobox-is-preferentially-expressed-in-typical-carcinoids-of-the-lung
#11
Krisztina Z Hanley, Zachary J Dureau, Cynthia Cohen, Dong M Shin, Taofeek K Owonikoko, Gabriel L Sica
BACKGROUND: Twenty-seven percent of neuroendocrine tumors (NETs) are associated with distant metastases, and in some patients, the primary site is unknown. Orthopedia homeobox protein (OTP) has been described as a useful marker for lung carcinoids (LCs) and for separating low-grade typical carcinoids (TCs) from intermediate-grade atypical carcinoids (ACs) in resection specimens. This study evaluated OTP, thyroid transcription factor 1 (TTF-1), and Ki-67 expression in fine-needle aspiration (FNA) samples of various NETs...
January 9, 2018: Cancer
https://www.readbyqxmd.com/read/29315479/long-term-management-of-moderate-to-severe-atopic-dermatitis-with-dupilumab-and-concomitant-topical-corticosteroids-liberty-ad-chronos-a-critical-appraisal
#12
J Thomson, A G H Wernham, H C Williams
AIM: Blauvelt et al. (The Lancet 2017; 389: 2287-303) aimed to compare the long-term efficacy and safety of dupilumab with medium-potency topical corticosteroids (TCS) versus placebo with TCS in adults with moderate-to-severe atopic dermatitis (AD). SETTING AND DESIGN: This multicentre randomised, double-blinded, placebo-controlled trial was conducted in hospitals, clinics and academic institutions across 161 sites in 14 countries. STUDY EXPOSURE: Adults with moderate-to-severe AD were randomly assigned (3:1:3) to receive subcutaneous dupilumab 300mg once weekly (qw) plus TCS, dupilumab 300mg every 2 weeks (q2w) plus TCS, or placebo plus TCS until week-52...
January 6, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29310425/treatment-with-phytoestrogens-reversed-triclosan-and-bisphenol-a-induced-anti-apoptosis-in-breast-cancer-cells
#13
Geum-A Lee, Kyung-Chul Choi, Kyung-A Hwang
Triclosan (TCS) and bisphenol A (BPA) are endocrine-disrupting chemicals that interfere with the hormone or endocrine system and may cause cancer. Kaempferol (Kaem) and 3,3'-diindolylmethane (DIM) are phytoestrogens that play chemopreventive roles in the inhibition of carcinogenesis and cancer progression. In this study, the influence of TCS, BPA, Kaem, and DIM on proliferation and apoptotic abilities of VM7Luc4E2 breast cancer cells were examined. MTT assay revealed that TCS (0.1-10 μM), BPA (0.1-10 μM) and E2 (0...
January 9, 2018: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/29306204/a-comparative-study-on-the-binary-and-ternary-mixture-toxicity-of-antibiotics-towards-three-bacteria-based-on-qsar-investigation
#14
Dali Wang, Xiaodan Wu, Zhifen Lin, Yangyang Ding
Antibiotics have become common pollutants in the environment. In most cases, the antibiotics in the environment exist as mixtures, posing joint effects on the organisms. Therefore, the mixture toxicity of the antibiotics can better reflect their environmental risks. In this paper, three types of commonly used antibiotics, i.e., sulfonamides (SAs), SA potentiators (SAPs) and tetracyclines (TCs) were investigated for their binary and tertiary mixture toxicity on three bacteria, Escherichia coli (E. coli), Vibrio fischeri (V...
January 3, 2018: Environmental Research
https://www.readbyqxmd.com/read/29298677/the-variome-of-pneumococcal-virulence-factors-and-regulators
#15
Gustavo Gámez, Andrés Castro, Alejandro Gómez-Mejia, Mauricio Gallego, Alejandro Bedoya, Mauricio Camargo, Sven Hammerschmidt
BACKGROUND: In recent years, the idea of a highly immunogenic protein-based vaccine to combat Streptococcus pneumoniae and its severe invasive infectious diseases has gained considerable interest. However, the target proteins to be included in a vaccine formulation have to accomplish several genetic and immunological characteristics, (such as conservation, distribution, immunogenicity and protective effect), in order to ensure its suitability and effectiveness. This study aimed to get comprehensive insights into the genomic organization, population distribution and genetic conservation of all pneumococcal surface-exposed proteins, genetic regulators and other virulence factors, whose important function and role in pathogenesis has been demonstrated or hypothesized...
January 3, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29291555/improved-photocatalytic-and-photoelectrochemical-performance-of-monoclinic-bismuth-vanadate-by-surface-defect-states-bi1-xvo4
#16
Ahmad Tayyebi, Tayyebeh Soltani, Hyeonseon Hong, Byeong-Kyu Lee
Due to visible light absorption and photochemical stability, Bismuth vanadate (BiVO4), recognized to be a promising photoanodes for designing high efficiency semiconductor photoelectrochemical (PEC) devices. To improve the photocatalytic and PEC performance of BiVO4, the porous monoclinic BiVO4 with surface bismuth vacancy (Bi1-xVO4 (s-m)) was obtained after the calcination of tetrahedron bismuth vanadate (BiVO4 (s-t)). The photocatalytic experiments showed that despite the relatively lower adsorption capacity of Bi1-xVO4 (s-m) as compared with BiVO4 (s-t), its photocatalytic activity for the photodegradation of tetracyclines (TCs) was 15-fold greater...
December 27, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29285119/trichosanthin-enhances-the-antitumor-effect-of-gemcitabine-in-non-small-cell-lung-cancer-via-inhibition-of-the-pi3k-akt-pathway
#17
Naren Tuya, Yadi Wang, Lanmei Tong, Weishi Gao, Rong Yu, Liying Xue
Gemcitabine (GEMZ) is the first-line therapy used against non-small cell lung cancer (NSCLC), and studies have focused on investigating the potential effects of agents combined with GEMZ to enhance the anticancer efficacy in NSCLC. Previous studies have reported that trichosanthin (TCS) has various physiological and pharmacological effects, including anti-human influenza virus enzymes, inhibition of protein synthesis and antitumor activity. The purpose of the present study was to investigate if TCS enhanced the antitumor effects of GEMZ in NSCLC...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29283969/development-of-a-trauma-system-and-optimal-placement-of-trauma-centers-using-geospatial-mapping
#18
Michael A Horst, Shreya Jammula, Brian W Gross, Eric H Bradburn, Alan D Cook, Juliet Altenburg, Madison Morgan, Danielle Von Nieda, Frederick B Rogers
BACKGROUND: The care of patients at individual trauma centers (TCs) has been carefully optimized, but not the placement of TCs within the trauma systems. We sought to objectively determine the optimal placement of trauma centers in Pennsylvania using geospatial mapping. METHODS: We used the Pennsylvania Trauma Systems Foundation (PTSF) and Pennsylvania Health Care Cost Containment Council (PHC4) registries for adult (age ≥15) trauma between 2003-2015 (n=377,540 and n=255,263)...
December 28, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29283966/under-triage-in-trauma-does-an-organized-trauma-network-capture-the-major-trauma-victim-a-statewide-analysis
#19
Michael A Horst, Shreya Jammula, Brian W Gross, Alan D Cook, Eric H Bradburn, Juliet Altenburg, Danielle Von Nieda, Madison Morgan, Frederick B Rogers
BACKGROUND: Proper triage of critically injured trauma patients to accredited trauma centers (TCs) is essential for survival and patient outcomes. We sought to determine the percentage of patients meeting trauma criteria who received care at non-trauma centers (NTCs) within the statewide trauma system that exists in the state of Pennsylvania. We hypothesized that a substantial proportion of the trauma population would be undertriaged to NTCs with undertriage rates (UTR) decreasing with increasing severity of injury...
December 28, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29280274/a-high-aspect-ratio-serpentine-structure-for-use-as-a-strain-insensitive-stretchable-transparent-conductor
#20
Sungwoo Jang, Choelgyu Kim, Jung Jin Park, Ming Liang Jin, Seon Joon Kim, O Ok Park, Taek-Soo Kim, Hee-Tae Jung
The development of strain-insensitive stretchable transparent conductors (TCs) is essential for manufacturing stretchable electronics. Despite recent progress, achieving a high optoelectronic performance under applied strain of 50% continues to present a significant challenge in this research field. Herein, an ultratall and ultrathin high aspect ratio serpentine metal structure is described that exhibits a remarkable stretching ability (the resistance remains constant under applied strain of 100%) and simultaneously provides an excellent transparent conducting performance (with a sheet resistance of 7...
December 27, 2017: Small
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