Ann-Kathrin Fröhlich, Jan Porthun, Khawaja M Talha, Alessia Lena, Sara Hadzibegovic, Ursula Wilkenshoff, Frederike Sonntag, Anja Nikolski, Luisa Valentina Ramer, Tanja Zeller, Ulrich Keller, Lars Bullinger, Stefan D Anker, Wilhelm Haverkamp, Stephan von Haehling, Wolfram Doehner, Ursula Rauch, Carsten Skurk, John G F Cleland, Javed Butler, Andrew J S Coats, Ulf Landmesser, Mahir Karakas, Markus S Anker
BACKGROUND: Growth hormone (GH) resistance is characterized by high GH levels but low levels of insulin-like growth factor-I (IGF-I) and growth hormone binding protein (GHBP) and, for patients with chronic disease, is associated with the development of cachexia. OBJECTIVES: We investigated whether GH resistance is associated with changes in left ventricular (LV) mass (cardiac wasting) in patients with cancer. METHODS: We measured plasma IGF-I, GH, and GHBP in 159 women and 148 men with cancer (83% stage III/IV)...
April 8, 2024: Clinical Research in Cardiology: Official Journal of the German Cardiac Society