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weight loss resistence

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https://www.readbyqxmd.com/read/28527156/the-effect-of-aerobic-or-aerobic-strength-exercise-on-body-composition-and-functional-capacity-in-patients-with-bmi-%C3%A2-35-after-bariatric-surgery-a-randomized-control-trial
#1
Alireza Hassannejad, Alireza Khalaj, Mohammad Ali Mansournia, Mastaneh Rajabian Tabesh, Zahra Alizadeh
BACKGROUND: Although previous studies suggested that bariatric surgery is the most effective and sustainable treatment method for morbid obesity in long term, but without changing in lifestyle, maintaining optimal weight loss is almost impossible. METHODS: Sixty morbid obese patients (BMI ≥ 35) were evaluated before and after 12 weeks of bariatric surgery in order to compare the impact of two different exercise programs on body composition and functional capacity outcomes...
May 19, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28526377/orange-juice-allied-to-a-reduced-calorie-diet-results-in-weight-loss-and-ameliorates-obesity-related-biomarkers-a-randomized-controlled-trial
#2
Carolina Ribeiro, Grace Dourado, Thais Cesar
OBJECTIVE: Assumptions have linked orange juice (OJ) consumption with weight gain and adverse effects on health due to its sugar content; however, epidemiologic studies have not shown increased risk for overweight or obesity with the consumption of 100% OJ. The aim of this study was to verify whether the combination of a reduced-calorie diet (RCD) and 100% OJ contribute to weight loss, promote changes in glucose and lipid metabolism, and improve diet quality in obese individuals. METHODS: A randomized controlled trial with 78 obese patients (age 36 ± 1 y, body mass index [BMI] 33 ± 3 kg/m(2)) were enrolled in two groups: Individuals in the OJ group submitted to an RCD that included OJ (500 mL/d), and individuals in the control group submitted to an RCD without OJ...
June 2017: Nutrition
https://www.readbyqxmd.com/read/28515955/effects-of-resistant-dextrin-for-weight-loss-in-overweight-adults-a-systematic-review-with-a-meta-analysis-of-randomized-controlled-trials
#3
Junichi Mukai, Yuta Tsuge, Michiko Yamada, Katsuya Otori, Koichiro Atsuda
BACKGROUND: Randomized controlled trials (RCTs) reported that resistant dextrin (RD) exerted pleiotropic effects on humans. However, limited information is available on the effects of RD for weight loss. We conducted a systematic review with a meta-analysis to summarize the available literature and compare the efficacy of RD for weight loss with that of a placebo in overweight adults. METHODS: We searched the electronic databases MEDLINE, EMBASE, The Cochrane Central Register of Controlled Trials (CENTRAL), CINAHL, Web of Science, ClincalTrials...
2017: Journal of Pharmaceutical Health Care and Sciences
https://www.readbyqxmd.com/read/28514618/aerobic-or-resistance-exercise-or-both-in-dieting-obese-older-adults
#4
Dennis T Villareal, Lina Aguirre, A Burke Gurney, Debra L Waters, David R Sinacore, Elizabeth Colombo, Reina Armamento-Villareal, Clifford Qualls
BACKGROUND: Obesity causes frailty in older adults; however, weight loss might accelerate age-related loss of muscle and bone mass and resultant sarcopenia and osteopenia. METHODS: In this clinical trial involving 160 obese older adults, we evaluated the effectiveness of several exercise modes in reversing frailty and preventing reduction in muscle and bone mass induced by weight loss. Participants were randomly assigned to a weight-management program plus one of three exercise programs - aerobic training, resistance training, or combined aerobic and resistance training - or to a control group (no weight-management or exercise program)...
May 18, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28511348/integrated-flood-hazard-assessment-based-on-spatial-ordered-weighted-averaging-method-considering-spatial-heterogeneity-of-risk-preference
#5
Yangfan Xiao, Shanzhen Yi, Zhongqian Tang
Flood is the most common natural hazard in the world and has caused serious loss of life and property. Assessment of flood prone areas is of great importance for watershed management and reduction of potential loss of life and property. In this study, a framework of multi-criteria analysis (MCA) incorporating geographic information system (GIS), fuzzy analytic hierarchy process (AHP) and spatial ordered weighted averaging (OWA) method was developed for flood hazard assessment. The factors associated with geographical, hydrological and flood-resistant characteristics of the basin were selected as evaluation criteria...
May 11, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28508276/effects-of-sleeve-gastrectomy-on-serum-12%C3%AE-hydroxylated-bile-acids-in-a-diabetic-rat-model
#6
Minggang Wang, Qunzheng Wu, Haibin Xie, Yi Shao, Mingwei Zhong, Xiang Zhang, Shaozhuang Liu, Xiao He, Sanyuan Hu, Guangyong Zhang
BACKGROUND: Diabetes mellitus is a prevalent disease that endangers human health. Bariatric surgery can effectively relieve insulin resistance with elevated serum bile acids (BAs). 12α-Hydroxylated BAs were previously reported to be associated with insulin resistance. The aim of this study was to analyze changes in 12α-hydroxylated BA composition and possible associated mechanisms in diabetic rats following sleeve gastrectomy (SG). METHODS: SG and sham operations were performed in diabetic rats induced by high-fat diet feeding and streptozotocin...
May 15, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28508131/muscle-wasting-in-chronic-kidney-disease
#7
Eduardo A Oliveira, Wai W Cheung, Kalodiah G Toma, Robert H Mak
Loss of lean body mass is a relevant component of the cachexia, or protein energy wasting (PEW), syndrome. Reduced muscle mass seems to be the most solid criterion for the presence of cachexia/PEW in patients with chronic kidney disease (CKD), and those with greater muscle mass loss have a higher risk of death. Children with CKD have many risk factors for lean mass and muscle wasting, including poor appetite, inflammation, growth hormone resistance, and metabolic acidosis. Mortality risks in patients with CKD increases as body mass index (BMI) and weight decreases...
May 15, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28507015/preserving-healthy-muscle-during-weight-loss
#8
REVIEW
Edda Cava, Nai Chien Yeat, Bettina Mittendorfer
Weight loss is the cornerstone of therapy for people with obesity because it can ameliorate or completely resolve the metabolic risk factors for diabetes, coronary artery disease, and obesity-associated cancers. The potential health benefits of diet-induced weight loss are thought to be compromised by the weight-loss-associated loss of lean body mass, which could increase the risk of sarcopenia (low muscle mass and impaired muscle function). The objective of this review is to provide an overview of what is known about weight-loss-induced muscle loss and its implications for overall physical function (e...
May 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/28506962/pair-feeding-but-not-insulin-phloridzin-or-rosiglitazone-treatment-curtails-markers-of-beta-cell-dedifferentiation-in-db-db-mice
#9
Emi Ishida, Ja Young Kim-Muller, Domenico Accili
Beta cell failure is a hallmark of type 2 diabetes. Among several cellular biological mechanisms of cellular dysfunction, we and others have recently proposed that dedifferentiation of beta cells can explain the slowly progressive onset and partial reversibility of beta-cell failure. Accordingly, we provided evidence of such processes in humans and experimental animal models of insulin-resistant diabetes. In this study, we asked whether beta cell dedifferentiation can be prevented with diet or pharmacological treatment of diabetes...
May 15, 2017: Diabetes
https://www.readbyqxmd.com/read/28505476/gender-difference-in-the-association-between-lower-muscle-mass-and-metabolic-syndrome-independent-of-insulin-resistance-in-a-middle-aged-and-elderly-taiwanese-population
#10
You-Ci Ou, Hai-Hua Chuang, Wen-Cheng Li, I-Shiang Tzeng, Jau-Yuan Chen
BACKGROUND: Loss of muscle mass was reported to be associated with metabolic syndrome (MetS), but little is known about the gender difference. Thus, the aim of this study was to evaluate the relationship between lower muscle mass and MetS and determine whether there was any gender difference or not. METHODS: A total of 394 middle-aged and elderly Taiwanese adults (138 males and 256 females) were enrolled and completed our health survey. They were stratified into three groups according to appendicular skeletal muscle mass divided by weight...
May 8, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28505155/oxidative-stress-and-expression-of-insulin-signaling-proteins-in-the-brain-of-diabetic-rats-role-of-nigella-sativa-oil-and-antidiabetic-drugs
#11
Mahmoud Balbaa, Shaymaa A Abdulmalek, Sofia Khalil
BACKGROUND AND OBJECTIVES: Insulin resistance of the brain is a specific form of type2-diabetes mellitus (T2DM) and the active insulin-signaling pathway plays a neuroprotective role against damaging conditions and Alzheimer's progression. The present study identifies the mediated emerging effects of the Nigella sativa oil (NSO) on the memory enhancing process, its anti-oxidative, acetylcholinestrase (AChE) inhibition, anti-brain insulin resistance and anti-amyloidogenic activities. In addition, the possible role of some anti-diabetic drugs in the neuro-protection processes and their effect in combination with NSO and/or the insulin receptor inhibitor IOMe-AG538 were investigated...
2017: PloS One
https://www.readbyqxmd.com/read/28502694/phase-ii-trial-of-the-pi3-kinase-inhibitor-buparlisib-bkm-120-with-or-without-enzalutamide-in-men-with-metastatic-castration-resistant-prostate-cancer
#12
Andrew J Armstrong, Susan Halabi, Patrick Healy, Joshi J Alumkal, Carolyn Winters, Julie Kephart, Rhonda L Bitting, Carey Hobbs, Colleen F Soleau, Tomasz M Beer, Rachel Slottke, Kelly Mundy, Evan Y Yu, Daniel J George
BACKGROUND: Phosphatidylinositol-3-kinase (PI3K) and androgen receptor pathway activation is common in metastatic castration resistant prostate cancer (mCRPC). Buparlisib is an oral, pan-class I PI3 kinase inhibitor. METHODS: This was a multisite single arm phase II trial of buparlisib 100 mg ± enzalutamide daily in men with mCRPC whose disease progressed on or who were not candidates for docetaxel. The primary end-point was the rate of radiographic/clinical progression-free survival (PFS) at 6 months...
May 11, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28501537/effects-of-exercise-on-liver-fat-and-metabolism-in-alcohol-drinkers
#13
David Houghton, Kate Hallsworth, Christian Thoma, Sophie Cassidy, Timothy Hardy, Sarah Heaps, Kieren G Hollingsworth, Roy Taylor, Christopher P Day, Steve Masson, Stuart McPherson, Quentin M Anstee, Michael I Trenell
BACKGROUND & AIMS: Exercise is an important component of obesity associated disorders and has been shown to reduce markers of non-alcoholic fatty liver disease (NAFLD). However, little is known about how these effects are influenced by alcohol intake. We performed a randomized controlled trial to investigate the effects of exercise on hepatic triglyceride content (HTGC) and metabolism in overweight or obese patients who consume alcohol. METHODS: We performed a prospective study of 27 patients (mean age 54±11years, body mass index [BMI], 31±4kg/m2) with >5% HTGC in the United Kingdom, consuming alcohol (mean 221±75 g/week)...
May 10, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28500394/bed-rest-and-resistive-vibration-exercise-unveil-novel-links-between-skeletal-muscle-mitochondrial-function-and-insulin-resistance
#14
Helena C Kenny, Floriane Rudwill, Laura Breen, Michele Salanova, Dieter Blottner, Tim Heise, Martina Heer, Stephane Blanc, Donal J O'Gorman
AIMS/HYPOTHESIS: Physical inactivity has broad implications for human disease including insulin resistance, sarcopenia and obesity. The present study tested the hypothesis that (1) impaired mitochondrial respiration is linked with blunted insulin sensitivity and loss of muscle mass in healthy young men, and (2) resistive vibration exercise (RVE) would mitigate the negative metabolic effects of bed rest. METHODS: Participants (n = 9) were maintained in energy balance during 21 days of bed rest with RVE and without (CON) in a crossover study...
May 12, 2017: Diabetologia
https://www.readbyqxmd.com/read/28497664/insulin-sensitizers-in-adolescents-with-polycystic-ovary-syndrome
#15
Trang N LE, Edmond P Wickham Iii, John E Nestler
Polycystic ovary syndrome (PCOS) is the most common disorder of androgen excess in women of reproductive age. The diagnosis of PCOS can be more challenging in adolescents than in adult women given significant overlap between normal puberty and the signs of PCOS, including acne, menstrual irregularity, and polycystic ovarian morphology. Optimal treatments for adult women with PCOS vary depending on patient risk factors and reproductive goals, but mainly include hormonal contraception and insulin sensitizers...
May 11, 2017: Minerva Pediatrica
https://www.readbyqxmd.com/read/28496128/a-systems-genetics-approach-identified-gpd1l-and-its-molecular-mechanism-for-obesity-in-human-adipose-tissue
#16
Hao He, Dianjianyi Sun, Yong Zeng, Ruifeng Wang, Wei Zhu, Shaolong Cao, George A Bray, Wei Chen, Hui Shen, Frank M Sacks, Lu Qi, Hong-Wen Deng
To explore novel molecular mechanisms underlying obesity, we applied a systems genetics framework to integrate risk genetic loci from the largest body mass index (BMI) genome-wide association studies (GWAS) meta-analysis with mRNA and microRNA profiling in adipose tissue from 200 subjects. One module was identified to be most significantly associated with obesity and other metabolic traits. We identified eight hub genes which likely play important roles in obesity metabolism and identified microRNAs that significantly negatively correlated with hub genes...
May 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28490735/design-synthesis-and-biological-evaluation-of-novel-hedgehog-inhibitors-for-treating-pancreatic-cancer
#17
Vinod Kumar, Amit Kumar Chaudhary, Yuxiang Dong, Haizhen A Zhong, Goutam Mondal, Feng Lin, Virender Kumar, Ram I Mahato
Hedgehog (Hh) pathway is involved in epithelial-mesenchymal transition (EMT) and cancer stem cell (CSC) maintenance resulting in tumor progression. GDC-0449, an inhibitor of Hh pathway component smoothened (Smo) has shown promise in the treatment of various cancers including pancreatic cancer. However, the emergence of resistance during GDC-0449 treatment with numerous side effects limits its use. Therefore, here we report the design, synthesis and evaluation of novel GDC-0449 analogs using N-[3-(2-pyridinyl) phenyl] benzamide scaffold...
May 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28489766/sex-difference-determined-the-role-of-sex-hormone-binding-globulin-in-obese-children-during-short-term-weight-reduction-program
#18
Fu-Min Wang, Chien-Ming Lin, Shao-Hung Lien, Li-Wei Wu, Ching-Feng Huang, Der-Ming Chu
The relationship between hyperinsulinemia and decreased sex hormone-binding globulin (SHBG) levels has been observed in obese adults and children. Weight reduction not only increased insulin sensitivity but also elevated serum SHBG levels in obese adults and children. However, the correlation between the changes in insulin resistance indices and serum SHBG concentration during weight reduction program (WRP) is not fully understood, particularly in obese children. This study is to evaluate whether SHBG level is a potential biomarker that can be used to assess insulin resistance in obese children during a short-term WRP...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28485680/is-the-calorie-concept-a-real-solution-to-the-obesity-epidemic
#19
Salvador Camacho, Andreas Ruppel
BACKGROUND: The obesity epidemic has been growing steadily across the whole world, and so far not a single country has been able to reverse it. The cause of obesity is stated by the World Health Organization as an energy imbalance between calories consumed and calories expended. However, growing evidence suggests that the calorie imbalance concept may not be sufficient to manage and reverse the obesity epidemic. OBJECTIVE: To discuss the use of the calorie imbalance concept and its elements as a tool for weight management as well as its possible negative consequences and implications for public health, with the aim to point toward the need of an updated concept for causes of obesity...
2017: Global Health Action
https://www.readbyqxmd.com/read/28481266/inspection-and-reconstruction-of-metal-roof-deformation-under-wind-pressure-based-on-bend-sensors
#20
Liman Yang, Langfu Cui, Yunhua Li, Chao An
Metal roof sheathings are widely employed in large-span buildings because of their light weight, high strength and corrosion resistance. However, their severe working environment may lead to deformation, leakage and wind-lift, etc. Thus, predicting these damages in advance and taking maintenance measures accordingly has become important to avoid economic losses and personal injuries. Conventionally, the health monitoring of metal roofs mainly relies on manual inspection, which unavoidably compromises the working efficiency and cannot diagnose and predict possible failures in time...
May 6, 2017: Sensors
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