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Disability assessment

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https://www.readbyqxmd.com/read/29684789/bipedal-hopping-timed-to-a-metronome-to-detect-impairments-in-anticipatory-motor-control-in-people-with-mild-multiple-sclerosis
#1
Megan C Kirkland, Alice Chen, Matthew B Downer, Brett J Holloway, Elizabeth M Wallack, Evan J Lockyer, Natasha C M Buckle, Courtney L Abbott, Michelle Ploughman
BACKGROUND: People with mild multiple sclerosis (MS) often report subtle deficits in balance and cognition but display no measurable impairment on clinical assessments. We examined whether hopping to a metronome beat had the potential to detect anticipatory motor control deficits among people with mild MS (Expanded Disability Status Scale ≤ 3.5). METHODS: Participants with MS (n = 13), matched controls (n = 9), and elderly subjects (n = 13) completed tests of cognition (Montreal Cognitive Assessment (MoCA)) and motor performance (Timed 25 Foot Walk Test (T25FWT))...
April 13, 2018: Clinical Biomechanics
https://www.readbyqxmd.com/read/29683965/effect-of-dexmedetomidine-on-cerebral-vasospasm-and-associated-biomarkers-in-a-rat-subarachnoid-hemorrhage-model
#2
Young Song, Beom Jin Lim, Do-Hyeong Kim, Jin Woo Ju, Dong Woo Han
BACKGROUND: The α2 adrenergic agonist dexmedetomidine (DEX) has huge potential for protecting against cerebral vasospasm, a leading cause of death and disability after subarachnoid hemorrhage (SAH). Biomarker assays for SAH have recently emerged as tools for predicting vasospasm and outcomes. We investigated the effects of DEX on vasospasm and assessed relevant biomarkers in a rat SAH model. METHODS: Male Wistar rats were randomly assigned to sham (n=10), vehicle (n=10), SAH (n=10), or SAH+ DEX (n=10) groups...
April 20, 2018: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/29683839/obesity-impacts-swelling-of-ankle-and-foot-joints-in-early-rheumatoid-arthritis-patients
#3
Veena K Ranganath, Erin L Duffy, Vikram K Garg, Thasia Woodworth, Mihaela Taylor, Harold E Paulus, Roy D Altman, David A Elashoff
OBJECTIVE: The evaluation of disease activity in obese rheumatoid arthritis (RA) patients presents challenges particularly in the clinical assessment of swollen joints. This study examines the effect of obesity on the American College of Rheumatology (ACR) core set measures used in assessing RA disease activity with specific focus on the swollen joint count (SJC). METHODS: We examined a cross-sectional cohort of 323 early seropositive RA patients (symptom duration ≤15 months)...
April 16, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29683230/evaluating-the-characteristics-of-the-grieving-process-in-people-with-intellectual-disability
#4
M Ángeles Alcedo Rodríguez, Leticia Cristóbal Fernández, Laura E Gómez Sánchez, Víctor B Arias González
BACKGROUND: The aim of this study was to examine the characteristics associated with the grieving process among a population with intellectual disability and the influence of particular variables. MATERIALS AND METHODS: The sample was composed of 380 participants with intellectual disability, on whose behalf 149 professionals completed a 20-item questionnaire with four Likert-type answer options, developed to evaluate the grieving process: Inventory of Grief and Coping Strategies in Intellectual Disability (IGCS-ID)...
April 23, 2018: Journal of Applied Research in Intellectual Disabilities: JARID
https://www.readbyqxmd.com/read/29682853/prosocial-vs-antisocial-coping-and-general-life-satisfaction-of-youth-with-mild-intellectual-disability
#5
P Kurtek
BACKGROUND: The purpose of this study was to find differences in general life satisfaction in adolescents with mild intellectual disability (MID) with respect to exhibiting a prosocial or an antisocial coping style. According to the ecological approach, using the antisocial style in a competitive school environment (a zero-sum game) may increase personal satisfaction, while in the family, which operates on the principles of 'common good' or 'common failure' (a non-zero-sum game), the antisocial style may reduce general satisfaction of the individual...
April 22, 2018: Journal of Intellectual Disability Research: JIDR
https://www.readbyqxmd.com/read/29682033/diagnostic-and-prognostic-capability-of-newer-magnetic-resonance-imaging-brain-sequences-in-diffuse-axonal-injury-patient
#6
Mayank Bansal, Virendra Deo Sinha, Juhi Bansal
Objectives: Diffuse axonal injury is one of the major causes of unconsciousness, profound neurologic deficits and persistent vegetative state after head trauma. In recent years, MR imaging has been gaining popularity as an adjunctive imaging method in patients with DAI. Our study aims to assess the relative diagnostic and prognostic capability of various MRI sequences. Patients and Methods: Retrospective observational study done in 1 year duration on 30 DAI patients...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29681973/effectiveness-of-massage-therapy-and-abdominal-hypopressive-gymnastics-in-nonspecific-chronic-low-back-pain-a-randomized-controlled-pilot-study
#7
L Bellido-Fernández, J J Jiménez-Rejano, R Chillón-Martínez, M A Gómez-Benítez, M De-La-Casa-Almeida, M Rebollo-Salas
Background: There are a great number of interventions in physiotherapy, but with little evidence of their effectiveness in chronic low back pain. Therefore, this study assesses effectiveness of Massage Therapy and Abdominal Hypopressive Gymnastics and the combination of both to decrease pain and lumbar disability while increasing joint mobility and quality of life in patients with chronic nonspecific low back pain. Methods: A randomized, single-blinded, controlled, clinical trial with sample ( n = 27) was comprised of patients between 20 and 65 years, diagnosed with pain of mechanical origin characterized by having a duration of at least 12 weeks and no serious complications...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29681244/orthopedic-knowledge-and-need-in-the-provincial-philippines-pilot-study-of-a-population-based-survey
#8
Christopher S Courtney, Thomas D Kirsch
IntroductionInterventions to reduce disability from acute orthopedic injuries require a primary assessment of knowledge and need. There are no previous studies to assess this need in the remote provincial islands of the Philippines, an area recurrently affected by natural disaster.ProblemA preliminary assessment of orthopedic knowledge and need was performed to be expanded for regional or national implementation. METHODS: Two independent surveys were conducted of households and mid-level providers who represent the first contact of care...
April 23, 2018: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/29681090/williams-beuren-syndrome-in-diverse-populations
#9
Paul Kruszka, Antonio R Porras, Deise Helena de Souza, Angélica Moresco, Victoria Huckstadt, Ashleigh D Gill, Alec P Boyle, Tommy Hu, Yonit A Addissie, Gary T K Mok, Cedrik Tekendo-Ngongang, Karen Fieggen, Eloise J Prijoles, Pranoot Tanpaiboon, Engela Honey, Ho-Ming Luk, Ivan F M Lo, Meow-Keong Thong, Premala Muthukumarasamy, Kelly L Jones, Khadija Belhassan, Karim Ouldim, Ihssane El Bouchikhi, Laila Bouguenouch, Anju Shukla, Katta M Girisha, Nirmala D Sirisena, Vajira H W Dissanayake, C Sampath Paththinige, Rupesh Mishra, Monisha S Kisling, Carlos R Ferreira, María Beatriz de Herreros, Ni-Chung Lee, Saumya S Jamuar, Angeline Lai, Ee Shien Tan, Jiin Ying Lim, Cham Breana Wen-Min, Neerja Gupta, Stephanie Lotz-Esquivel, Ramsés Badilla-Porras, Dalia Farouk Hussen, Mona O El Ruby, Engy A Ashaat, Siddaramappa J Patil, Leah Dowsett, Alison Eaton, A Micheil Innes, Vorasuk Shotelersuk, Ëben Badoe, Ambroise Wonkam, María Gabriela Obregon, Brian H Y Chung, Milana Trubnykova, Jorge La Serna, Bertha Elena Gallardo Jugo, Miguel Chávez Pastor, Hugo Hernán Abarca Barriga, Andre Megarbane, Beth A Kozel, Mieke M van Haelst, Roger E Stevenson, Marshall Summar, A Adebowale Adeyemo, Colleen A Morris, Danilo Moretti-Ferreira, Marius George Linguraru, Maximilian Muenke
Williams-Beuren syndrome (WBS) is a common microdeletion syndrome characterized by a 1.5Mb deletion in 7q11.23. The phenotype of WBS has been well described in populations of European descent with not as much attention given to other ethnicities. In this study, individuals with WBS from diverse populations were assessed clinically and by facial analysis technology. Clinical data and images from 137 individuals with WBS were found in 19 countries with an average age of 11 years and female gender of 45%. The most common clinical phenotype elements were periorbital fullness and intellectual disability which were present in greater than 90% of our cohort...
May 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29680881/baricitinib-in-patients-with-rheumatoid-arthritis-and-an-inadequate-response-to-conventional-disease-modifying-antirheumatic-drugs-in-united-states-and-rest-of-world-a-subset-analysis
#10
Alvin F Wells, Maria Greenwald, John D Bradley, Jahangir Alam, Vipin Arora, Cynthia E Kartman
INTRODUCTION: This article evaluates the efficacy and safety of baricitinib 4 mg versus placebo in United States including Puerto Rico (US) and rest of the world (ROW) subpopulations using data pooled from RA-BEAM and RA-BUILD, which enrolled patients with moderate-to-severe adult-onset rheumatoid arthritis (RA). METHODS: In RA-BEAM, patients with an inadequate response (IR) to methotrexate, at least one X-ray erosion, and high sensitivity C-reactive protein (hsCRP) ≥ 6 mg/L were randomized to placebo or orally administered baricitinib 4 mg daily or subcutaneously administered adalimumab 40 mg every other week...
April 21, 2018: Rheumatology and Therapy
https://www.readbyqxmd.com/read/29680317/a-double-blind-placebo-controlled-phase-ii-randomised-cross-over-trial-investigating-the-use-of-duloxetine-for-the-treatment-of-chemotherapy-induced-peripheral-neuropathy
#11
Eva Battaglini, Susanna B Park, Elizabeth H Barnes, David Goldstein
BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) is a significant side effect of cancer treatment, potentially leading to early cessation of chemotherapy, enduring symptoms and long-lasting disability. Evidence from preclinical and clinical studies suggests that duloxetine, a serotonin-noradrenaline reuptake inhibitor, may be effective in the symptomatic treatment of CIPN. This double blind, placebo controlled, phase II randomised cross-over trial aims to determine whether treatment with duloxetine results in a reduction in chronic neuropathic symptoms experienced as a result of neurotoxic chemotherapy treatment...
April 19, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29680266/physiological-movement-disorder-like-features-during-typical-motor-development
#12
M J Kuiper, R Brandsma, L Vrijenhoek, M A J Tijssen, H Burger, B Dan, D A Sival
AIM: To compare physiological age-relatedness between dyskinesia (dystonia/choreoathetosis), dystonia and ataxia rating scale scores in healthy children. METHOD: Three movement disorders specialists quantified dyskinetic-like features in healthy children (n = 52; 4-16 years) using the Dyskinesia Impairment Scale (DIS = DIS-choreoathetosis (DIS-C) + DIS-dystonia (DIS-D)). We compared the age-related regression coefficients of the DIS with data processed from previous studies on dystonia and ataxia rating scales (Burke-Fahn-Marsden Movement and Disability Scales (BFMMS and BFMDS) and Scale for Assessment and Rating of Ataxia (SARA), International Cooperative Ataxia Rating Scale (ICARS) and Brief Ataxia Rating Scale (BARS))...
March 30, 2018: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29680162/baseline-patient-reported-outcomes-are-more-consistent-predictors-of-long-term-functional-disability-than-laboratory-imaging-or-joint-count-data-in-patients-with-early-inflammatory-arthritis-a-systematic-review
#13
REVIEW
James M Gwinnutt, Charlotte A Sharp, Deborah P M Symmons, Mark Lunt, Suzanne M M Verstappen
OBJECTIVE: To assess baseline predictors of long-term functional disability in patients with inflammatory arthritis (IA). METHODS: We conducted a systematic review of the literature from 1990 to 2017 using MEDLINE and EMBASE. Studies were included if (i) they were prospective observational studies, (ii) all patients had IA with symptom duration ≤2 years at baseline, (iii) follow-up was at least 5 years, and (iv) baseline predictors of HAQ score at long-term follow-up (i...
March 15, 2018: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29679991/empirical-evidence-for-discrete-neurocognitive-subgroups-in-patients-with-non-psychotic-major-depressive-disorder-clinical-implications
#14
Shenghong Pu, Takamasa Noda, Shiori Setoyama, Kazuyuki Nakagome
BACKGROUND: Neuropsychological deficits are present across various cognitive domains in major depressive disorder (MDD). However, a consistent and specific profile of neuropsychological abnormalities has not yet been established. METHODS: We assessed cognition in 170 patients with non-psychotic MDD using the Brief Assessment of Cognition in Schizophrenia and the scores were compared with those of 42 patients with schizophrenia as a reference for severity of cognitive impairment...
April 22, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29679730/stand-alone-lateral-lumbar-interbody-fusion-for-the-treatment-of-symptomatic-adjacent-segment-degeneration-following-previous-lumbar-fusion
#15
Philip K Louie, Arya G Varthi, Ankur S Narain, Victor Lei, Daniel D Bohl, Grant D Shifflett, Frank M Phillips
BACKGROUND CONTEXT: Revision posterior decompression and fusion for patients with symptomatic ASD is associated with significant morbidity and is technically challenging. The use of a stand-alone LLIF in patients with symptomatic ASD may avoid many of the complications associated with revision posterior surgery. PURPOSE: To assess the clinical and radiographic outcomes of patients who underwent stand-alone lateral lumbar interbody fusion (LLIF) for symptomatic adjacent segment disease (ASD)...
April 18, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29679727/the-influence-of-hand-grip-strength-on-surgical-outcomes-after-surgery-for-degenerative-lumbar-spinal-stenosis-a-preliminary-result
#16
Feng Shen, Ho-Joong Kim, Na-Kyoung Lee, Heoung-Jae Chun, Bong-Soon Chang, Choon-Ki Lee, Jin S Yeom
BACKGROUND CONTEXT: Although a number of prognostic factors have been demonstrated to be associated with surgical outcome of degenerative lumbar spinal stenosis (DLSS), no study has investigated the relation between hand grip strength (HGS) and treatment outcome of DLSS. PURPOSE: The purpose of this study was to examine the influence of HGS on surgical outcomes after surgery for patients with DLSS. STUDY DESIGN: An observational study PATIENT SAMPLE: Patients who underwent spine surgery for DLSS...
April 18, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29679136/the-pedicle-instrumentation-and-percutaneous-elevation-pi-pe-a-new-cementless-surgical-technique-in-type-a-post-traumatic-vertebral-fractures
#17
Andrea Piazzolla, Giuseppe Solarino, Davide Bizzoca, Claudia Parato, Gaetano Monteleone, Franca Dicuonzo, Biagio Moretti
PURPOSE: To investigate if bone substitutes are strictly necessary to restore the vertebral body height and improve the clinical outcome, in patients with thoracolumbar or lumbar AO type A post-traumatic vertebral fractures, managed with balloon kyphoplasty combined with posterior screw and rod system. METHODS: 105 patients with post-traumatic thoracolumbar spine fracture were recruited. At baseline, the patients underwent a CT and an MRI of the spine. Clinical evaluation was performed, using the Visual Analog Scale (VAS) and the Oswestry Disability Index (ODI), at baseline, 48 h after surgery, at 3-month follow-up (FU), 6-month FU, 48 h after the instrumentation removal and at 24-month FU...
April 20, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29678563/pilot-randomized-trial-of-integrated-cognitive-behavioral-therapy-and-neuromuscular-training-for-juvenile-fibromyalgia-the-fit-teens-program
#18
Susmita Kashikar-Zuck, William R Black, Megan Pfeiffer, James Peugh, Sara E Williams, Tracy V Ting, Staci Thomas, Katie Kitchen, Gregory D Myer
Cognitive-behavioral therapy (CBT) improves coping and daily functioning in adolescents with juvenile fibromyalgia (JFM), but is less effective in reducing pain. This pilot trial evaluated the efficacy of a novel intervention (Fibromyalgia Integrative Training for Teens; FIT Teens) which integrates CBT with specialized neuromuscular exercise training to enhance the impact of treatment on reducing pain and disability. Forty adolescents with JFM (12-18 years) were randomized to CBT-only or FIT Teens. Treatment was conducted in group-based sessions over 8 weeks with assessments at baseline, post-treatment, and 3-month follow-up (primary endpoint)...
April 17, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29678342/spending-on-health-and-hiv-aids-domestic-health-spending-and-development-assistance-in-188-countries-1995-2015
#19
(no author information available yet)
BACKGROUND: Comparable estimates of health spending are crucial for the assessment of health systems and to optimally deploy health resources. The methods used to track health spending continue to evolve, but little is known about the distribution of spending across diseases. We developed improved estimates of health spending by source, including development assistance for health, and, for the first time, estimated HIV/AIDS spending on prevention and treatment and by source of funding, for 188 countries...
April 17, 2018: Lancet
https://www.readbyqxmd.com/read/29678257/-functional-status-as-an-independent-risk-factor-in-elderly-patients-admitted-to-an-intensive-care-unit
#20
Federico Gordo, Cristina Castro, Inés Torrejón, Sonia Bartolomé, Francisco Coca, Ana Abella
OBJECTIVE: To assess the association of previous functional status in elderly patients admitted to the ICU, estimated by the Barthel and Short Form-Late Life Function and Disability instrument scales, and the relationship with prognosis and functional capacity at hospital discharge. MATERIAL AND METHODS: Observational prospective study of ICU-admitted patients older than 74 years, with a length of stay greater than 48hours. Demographic data, social background, comorbidities, disability questionnaire (Barthel, Short Form-Late Life Function and Disability instrument), main diagnosis and severity (SAPS 3) on ICU admission were recorded...
April 17, 2018: Revista Española de Geriatría y Gerontología
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