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https://www.readbyqxmd.com/read/29933336/determinants-of-patient-satisfaction-two-year-after-spinal-deformity-surgery-a-latent-class-analysis
#1
Jingyan Yang, Virginie Lafage, Renaud Lafage, Justin Smith, Eric O Klineberg, Christopher I Shaffrey, Gregory Mundis, Richard Hostin, Douglas Burton, Christopher P Ames, Shay Bess, Han Jo Kim, Frank Schwab
STUDY DESIGN: Retrospective review of prospective multicenter database. OBJECTIVE: To investigate the determinants of patient satisfaction with respect to changes in functional limitations two-year after spinal deformity surgery. SUMMARY OF BACKGROUND DATA: For operatively treated adult spine deformity (ASD), patient satisfaction has become an important component of evaluating quality of care. METHODS: 430 operative ASD patients with two-year follow-up were analyzed...
June 21, 2018: Spine
https://www.readbyqxmd.com/read/29933123/the-effect-of-upper-instrumented-vertebra-level-on-cervical-sagittal-alignment-in-lenke-1-adolescent-idiopathic-scoliosis
#2
Ismail Emre Ketenci, Hakan Serhat Yanik, Sevki Erdem
BACKGROUND: This study aimed to evaluate the relationship between upper instrumented vertebra (UIV) level and cervical sagittal alignment (CSA) in Lenke 1 adolescent idiopathic scoliosis (AIS) patients, treated with posterior instrumentation. The hypothesis was that higher level of UIV would cause decreased cervical lordosis. METHODS: 63 Lenke 1 AIS patients that underwent posterior fusion with pedicle screw instrumentation were retrospectively evaluated. Patients were divided into three groups according to UIV level (T2, T3, T4)...
June 19, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29933089/new-technology-for-surgical-treatment-of-osteoporotic-vertebral-compression-fractures-the-transvertebral-bone-graft-and-fixation
#3
Yang Hou, Jingchuan Sun, Jiangang Shi, Guodong Shi, Guohua Xu, Yongfei Guo, Dan Han
OBJECTIVE: To introduce an innovative surgical technique named as trans-vertebral bone graft and augmentation(TBGA) and evaluate its clinical efficacy with balloon Kyphoplasty (BKP) as control for osteoporotic VCFs. METHODS: A total of 81 patients with one-level osteoporotic VCFs received the TBGA(n=38) or BKP(n=43) from October 2012 to January 2015. The average follow-up period of the patients was 27.9 months. The patients were evaluated using plain radiographs, computerized tomography and magnetic resonance imaging preoperatively...
June 19, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29932986/care-quality-and-spending-among-commercially-insured-children-with-disabilities
#4
Alyna T Chien, Sara L Toomey, Dennis Z Kuo, Jeanne Van Cleave, Amy J Houtrow, Megumi J Okumura, Matthew Y Westfall, Carter R Petty, Jessica A Quinn, Karen A Kuhlthau, Mark A Schuster
OBJECTIVE: To identify opportunities to improve care value for children with disabilities (CWD), we examined CWD prevalence within a commercially insured population and compared outpatient care quality and annual health plan spending levels for CWD relative to children with complex medical conditions without disabilities, children with chronic conditions that are not complex, and children without disabling, complex, or chronic conditions. METHODS: Cross-sectional study of 1,118,081 person-years of Blue Cross Blue Shield Massachusetts data for beneficiaries aged 1-19 years old during 2008-2012...
June 19, 2018: Academic Pediatrics
https://www.readbyqxmd.com/read/29932874/an-overview-of-systematic-reviews-on-patient-reported-outcome-measures-used-on-neck-disorders
#5
Pavlos Bobos, Joy C MacDermid, David M Walton, Anita Gross, P Lina Santaguida
Study Design Overview of systematic reviews. Background The evaluation of psychometric properties of neck Patient-Reported Outcome Measures (PROMs) from multiple systematic reviews (SRs) will provide a broader view and may identify potential conflicting or consistent results for their psychometric properties. Objective The purpose of this study was to conduct an overview of SRs and synthesize evidence to establish the current state of knowledge on psychometric properties of PROM's for patients with neck disorders...
June 22, 2018: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/29932457/epidermolysis-bullosa-simplex-generalized-severe-induces-a-th17-response-and-is-improved-by-apremilast-treatment
#6
E Castela, M K Tulic, A Rozières, E Bourrat, J-F Nicolas, J Kanitakis, P Vabres, D Bessis, J Mazereeuw, F Morice-Picard, D Baty, F Berard, J-P Lacour, T Passeron, C Chiaverini
BACKGROUND: Epidermolysis bullosa simplex generalized severe is a genetic disorder caused by mutation in KRT5 or KRT14 genes. Usually considered as a mechanical disease, recent data argue for additional inflammatory mechanisms. OBJECTIVES: The aim of this study was to assess the inflammation in the skin of patients with EBS. METHODS: A first immunohistochemical retrospective study was performed on frozen skin samples from 17 EBS-gen sev patients...
June 22, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29932344/repeated-mild-closed-head-injuries-induce-long-term-white-matter-pathology-and-neuronal-loss-that-are-correlated-with-behavioral-deficits
#7
Eric M Gold, Vitaly Vasilevko, Jonathan Hasselmann, Casey Tiefenthaler, Danny Hoa, Kasuni Ranawaka, David H Cribbs, Brian J Cummings
An estimated 5.3 million Americans are living with a disability from a traumatic brain injury (TBI). There is emerging evidence of the detrimental effects from repeated mild TBIs (rmTBIs). rmTBI manifests its own unique set of behavioral and neuropathological changes. A subset of individuals exposed to rmTBI develop permanent behavioral and pathological consequences, defined postmortem as chronic traumatic encephalopathy. We have combined components of two classic rodent models of TBI, the controlled cortical impact model and the weight drop model, to develop a repeated mild closed head injury (rmCHI) that produces long-term deficits in several behaviors that correlate with neuropathological changes...
January 2018: ASN Neuro
https://www.readbyqxmd.com/read/29932027/circulating-biomarkers-in-migraine-new-opportunities-for-precision-medicine
#8
Patrizia Ferroni, Piero Barbanti, Antonella Spila, Federica Fratangeli, Cinzia Aurilia, Luisa Fofi, Gabriella Egeo, Fiorella Guadagni
Background Migraine is the most common neurological disorder and the second most disabling human condition, whose pathogenesis is favored by a combination of genetic, epigenetic, and environmental factors. In recent years, several efforts have been made to identify reliable biomarker(s) useful to monitor disease activity and/or ascertain the response to a specific treatment. Objective To review the current evidence on the potential biological markers associated with migraine. Methods A structured search of peer-reviewed research literature was performed by searching major publications databases up to December 2017...
June 22, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29931773/association-between-hand-grip-strength-with-weaning-and-intensive-care-outcomes-in-copd-patients-a-pilot-study
#9
Aliae Ar Mohamed-Hussein, Hoda A Makhlouf, Zahraa I Selim, Waleed Gamaleldin Saleh
BACKGROUND: In COPD weight loss and muscle wasting contribute significantly to morbidity, disability and handicap. Dominant-handgrip strength for evaluation of muscle strength has not been tested as a parameter to predict outcome of weaning from mechanical ventilation (MV). OBJECTIVES: to evaluate the association between handgrip strength and the duration and success of weaning and extubation outcome. PATIENTS AND METHODS: This prospective study included 34 COPD patients requiring MV for at least 48 hours...
June 22, 2018: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29931626/do-sarcopenia-and-or-osteoporosis-increase-the-risk-of-frailty-a-4-year-observation-of-the-second-and-third-road-study-surveys
#10
N Yoshimura, S Muraki, H Oka, T Iidaka, R Kodama, C Horii, H Kawaguchi, K Nakamura, T Akune, S Tanaka
In this 4-year follow-up study including 1083 subjects (≥ 60 years), the prevalence of frailty was estimated to be 5.6%; osteoporosis was found to be significantly associated with frailty. Moreover, the presence of both osteoporosis and sarcopenia increased the risk of frailty compared to the presence of osteoporosis or sarcopenia alone. INTRODUCTION: This study aims to examine the contribution of sarcopenia and osteoporosis to the occurrence of frailty using 4-year follow-up information of a population-based cohort study...
June 21, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29930986/treatment-satisfaction-and-medication-adherence-among-hypertensive-patients-seeking-care-in-selected-hospitals-in-ibadan-nigeria
#11
D T Ajayi, B O Adedokun, D O Owoeye, O M Akpa
Poor adherence to hypertension treatment is a major health-related problem, and a significant risk factor for complications, disability and hypertension associated mortality. There is a paucity of evidence on the impact of treatment satisfaction on medication adherence among hypertensive patients in Nigeria. This study aimed to determine the association between treatment satisfaction and medication adherence among hypertensive patients in Ibadan, Nigeria. A descriptive cross-sectional study was conducted, wherein hypertensive patients were consecutively recruited from 5 hospitals in Ibadan, Nigeria...
February 2018: Archives of basic and applied medicine
https://www.readbyqxmd.com/read/29929384/can-drawings-help-assessing-dementia-caregivers-burden-a-preliminary-study
#12
Perla Werner, Hanan AboJabel
The use of quantitative self-report methods for assessing the stress associated with dementia caregiving, especially among minority groups, has been lately criticized. The aim of this study was to examine whether Human Figures Drawings might provide a tool for assessing caregivers' burden. Sixty Israeli Arabs - 30 family caregivers of a person with dementia and 30 gender and age-matched non-caregivers - were asked to draw a caregiver of an elderly person with dementia and a caregiver of an elderly person with a physical disability...
January 1, 2018: Dementia
https://www.readbyqxmd.com/read/29929043/mutations-in-the-neuroblastoma-amplified-sequence-gene-in-a-family-affected-by-acrofrontofacionasal-dysostosis-type-1
#13
Eleonora Palagano, Giulia Zuccarini, Paolo Prontera, Renato Borgatti, Gabriela Stangoni, Sandro Elisei, Stefano Mantero, Ciro Menale, Antonella Forlino, Paolo Uva, Manuela Oppo, Paolo Vezzoni, Anna Villa, Giorgio R Merlo, Cristina Sobacchi
Acrofrontofacionasal Dysostosis type 1 (AFFND1) is an extremely rare, autosomal recessive syndrome, comprising facial and skeletal abnormalities, short stature and intellectual disability. We analyzed an Indian family with two affected siblings by exome sequencing and identified a novel homozygous truncating mutation in the Neuroblastoma-Amplified Sequence (NBAS) gene in the patients' genome. Mutations in the NBAS gene have recently been associated with different phenotypes mainly involving skeletal formation, liver and cognitive development...
June 18, 2018: Bone
https://www.readbyqxmd.com/read/29928653/navigational-cue-effects-in-alzheimer-s-disease-and-posterior-cortical-atrophy
#14
Keir X X Yong, Ian D McCarthy, Teresa Poole, Tatsuto Suzuki, Biao Yang, Amelia M Carton, Catherine Holloway, Nikolaos Papadosifos, Derrick Boampong, Julia Langham, Catherine F Slattery, Ross W Paterson, Alexander J M Foulkes, Jonathan M Schott, Chris Frost, Nick Tyler, Sebastian J Crutch
Objective: Deficits in spatial navigation are characteristic and disabling features of typical Alzheimer's disease (tAD) and posterior cortical atrophy (PCA). Visual cues have been proposed to mitigate such deficits; however, there is currently little empirical evidence for their use. Methods: The effect of visual cues on visually guided navigation was assessed within a simplified real-world setting in individuals with tAD ( n  = 10), PCA ( n  = 8), and healthy controls ( n  = 12)...
June 2018: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29928603/the-compression-of-l5-nerve-root-single-or-double-sites-radiographic-graded-signs-intra-operative-detect-technique-and-clinical-outcomes
#15
Ai-Min Wu, Kai Zhang, Xun-Lin Li, Xiao-Fei Cheng, Tang-Jun Zhou, Lin Du, Chen Chen, Hai-Jun Tian, Xiao-Jiang Sun, Chang-Qing Zhao, Yan Michael Li, Jie Zhao
Background: The L5 nerve root could be compressed at both L4-5 and L5-S1 regions. If L5 nerve root has confirmed compression at L4-5 level and questionable compression at L5-S1 foramina, performing both surgeries at L4-5 and L5-S1 levels may induce unnecessary extra surgery on L5-S1; however, ignoring foraminal stenosis of L5/S1 may require re-exploration. Methods: Two hundred seventeen patients with L5 nerve root compressed at L4-5 lateral access were performed with L4-5 decompression and interbody fusion...
May 2018: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29928559/clinical-etiological-anatomical-and-bacteriological-study-of-diabetic-foot-patients-results-of-a-single-center-study
#16
Ashwinikumar Patil, Datta More, Anant Patil, Kishor A Jadhav, Myriam E Vijil Mejia, Suresh S Patil
OBJECTIVE: To examine the clinical pattern of foot-related complications in type 2 diabetes patients. MATERIAL AND METHODS: A cross-sectional study was conducted among indoor, adult type 2 diabetes patients with risk factors for diabetic foot complications. The diabetic neuropathy symptom score (DNSS), Doppler scanning, ankle brachial pressure index (ABPI) assessment, neuropathy assessment, neuropathic disability score (NDS), biothesiometry evaluation, and bacteriological examination was performed...
April 18, 2018: Curēus
https://www.readbyqxmd.com/read/29928257/innovation-in-systems-of-care-in-acute-phase-of-ischemic-stroke-the-experience-of-the-catalan-stroke-programme
#17
REVIEW
Rosa M Vivanco-Hidalgo, Sònia Abilleira, Mercè Salvat-Plana, Aida Ribera, Guillem Gallofré, Miquel Gallofré
Stroke, and mainly ischemic stroke, is the second cause of death and disability. To confront the huge burden of this disease, innovative stroke systems of care are mandatory. This requires the development of national stroke plans to offer the best treatment to all patients eligible for reperfusion therapies. Key elements for success include a high level of organization, close cooperation with emergency medical services for prehospital assessment, an understanding of stroke singularity, the development of preassessment tools, a high level of commitment of all stroke teams at Stroke Centres, the availability of a disease-specific registry, and local government involvement to establish stroke care as a priority...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29928022/characterization-of-normative-hand-movements-during-two-functional-upper-limb-tasks
#18
Aïda M Valevicius, Quinn A Boser, Ewen B Lavoie, Glyn S Murgatroyd, Patrick M Pilarski, Craig S Chapman, Albert H Vette, Jacqueline S Hebert
BACKGROUND: Dexterous hand function is crucial for completing activities of daily living (ADLs), which typically require precise hand-object interactions. Kinematic analyses of hand trajectory, hand velocity, and grip aperture provide valuable mechanistic insights into task performance, but there is a need for standardized tasks representative of ADLs that are amenable to motion capture and show consistent performance in non-disabled individuals. Our objective was to develop two standardized functional upper limb tasks and to quantitatively characterize the kinematics of normative hand movement...
2018: PloS One
https://www.readbyqxmd.com/read/29927416/-scales-and-tests-in-the-rehabilitation-and-treatment-of-patients-with-spasticity-of-the-lower-limbs
#19
A P Kovalenko, O V Kamaeva, V K Misikov, Yu R Poleshchuk, M A Koshkarev
The problem-oriented approach in the rehabilitation of patients with spasticity requires careful assessment of the situation in the concept of The International Classification of Functioning, Disability and Health (ICF): impairment of the structure, functions and limitation of activity in specific environmental factors. Standardized tools in the assessment of muscle tone allow to get objective data about motor function. The use of the Modified Ashworth scale (MAS) and the Tardieu Scale are discussed. The standardized assessment of independent mobility is an important issue in outcome measuring...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29926999/the-czech-mental-health-study-czems-study-rationale-design-and-methods
#20
Petr Winkler, Tomáš Formánek, Karolína Mladá, Pavla Cermakova
OBJECTIVES: The CZEch Mental health Study (CZEMS) was launched to inform the ongoing mental health care reform. This paper describes rationale, methods, and the plan for the future analyses of this project. METHODS: A cross-sectional survey on a representative sample of the general adult noninstitutionalized population of the Czech Republic was conducted. Two-stage sampling was utilized and respondents were interviewed by centrally trained staff using a paper and pencil interviewing...
June 21, 2018: International Journal of Methods in Psychiatric Research
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