keyword
https://read.qxmd.com/read/38490295/long-term-follow-up-of-abatacept-post-transplantation-cyclophosphamide-and-sirolimus-abacys-based-haploidentical-transplantation-in-younger-patients-with-nonmalignant-diseases
#21
JOURNAL ARTICLE
Sarita Rani Jaiswal, Mahak Agarwal, Gitali Bhagawati, Bhudev Chandra Das, Prakash Baligar, Manoj Garg, Subhrajit Biswas, Suparno Chakrabarti
BACKGROUND: Haploidentical (Haplo) HCT for nonmalignant diseases (NMD) faces inherent challenges of both alloreactivity and graft failure. Building upon promising results from pilot studies, where abatacept was combined with post-transplantation cyclophosphamide (PTCy) and sirolimus (AbaCyS) in younger NMD patients undergoing haplo-HCT, we present the long-term outcomes of this protocol. STUDY DESIGN: On the back of uniform disease-specific conditioning regimens containing ATG (4...
March 13, 2024: Transplantation and cellular therapy
https://read.qxmd.com/read/38488241/po-2-reporter-composite-hydrogel-macroencapsulation-devices-for-magnetic-resonance-imaging-oxygen-quantification
#22
JOURNAL ARTICLE
Amy E Emerson, Yuka Sugamura, Jad Mazboudi, Tuhfah M Abdallah, Charmayne D Seaton, Azin Ghasemi, Vikram D Kodibagkar, Jessica D Weaver
Hydrogel cell encapsulation devices are a common approach to reduce the need for chronic systemic immunosuppression in allogeneic cell product transplantation. Macroencapsulation approaches are an appealing strategy, as they maximize graft retrievability and cell dosage within a single device; however, macroencapsulation devices face oxygen transport challenges as geometries increase from preclinical to clinical scales. Device design guided by computational approaches can facilitate graft oxygen availability to encapsulated cells in vivo but is limited without accurate measurement of oxygen levels within the transplant site and graft...
March 15, 2024: Journal of Biomedical Materials Research. Part A
https://read.qxmd.com/read/38486306/bioprinting-of-human-pluripotent-stem-cell-derived-corneal-endothelial-cells-with-hydrazone-crosslinked-hyaluronic-acid-bioink
#23
JOURNAL ARTICLE
Pyry Grönroos, Anni Mörö, Paula Puistola, Karoliina Hopia, Maija Huuskonen, Taina Viheriälä, Tanja Ilmarinen, Heli Skottman
BACKGROUND: Human corneal endothelial cells lack regenerative capacity through cell division in vivo. Consequently, in the case of trauma or dystrophy, the only available treatment modality is corneal tissue or primary corneal endothelial cell transplantation from cadaveric donor which faces a high global shortage. Our ultimate goal is to use the state-of-the-art 3D-bioprint technology for automated production of human partial and full-thickness corneal tissues using human stem cells and functional bioinks...
March 14, 2024: Stem Cell Research & Therapy
https://read.qxmd.com/read/38485702/unveiling-the-hidden-players-exploring-the-role-of-gut-mycobiome-in-cancer-development-and-treatment-dynamics
#24
REVIEW
Lingxi Li, Xiaowen Huang, Haoyan Chen
The role of gut fungal species in tumor-related processes remains largely unexplored, with most studies still focusing on fungal infections. This review examines the accumulating evidence suggesting the involvement of commensal and pathogenic fungi in cancer biological process, including oncogenesis, progression, and treatment response. Mechanisms explored include fungal influence on host immunity, secretion of bioactive toxins/metabolites, interaction with bacterial commensals, and migration to other tissues in certain types of cancers...
2024: Gut Microbes
https://read.qxmd.com/read/38485068/a-systematic-review-of-online-resources-for-the-dietary-management-of-hyperphosphatemia-in-people-with-chronic-kidney-disease
#25
JOURNAL ARTICLE
Most Murshida Begum, Annabel Biruete, Brandon Kistler, Anthony Meade, John Westhoff, David E St-Jules
OBJECTIVE: Internet search engines and social media websites are prominent and growing sources of dietary information for people with chronic kidney disease (CKD) and their healthcare providers. However, nutrition therapy for CKD is undergoing a paradigm shift, which may lead to inconsistent advice for managing hyperphosphatemia. The aim of this study was to summarize and evaluate online resources for phosphorus-specific nutrition therapy. DESIGN AND METHODS: Patient-facing resources were collected from Google, Yahoo, and Facebook in June-July 2021...
March 12, 2024: Journal of Renal Nutrition
https://read.qxmd.com/read/38478637/anti-laminin-332-antibodies-in-graft-versus-host-disease-associated-bullous-pemphigoid-after-allogeneic-peripheral-blood-stem-cell-transplantation
#26
JOURNAL ARTICLE
Yasutoshi Hida, Riho Kageji, Hirofumi Bekku, Norito Ishii
We report a 48-year-old woman with bullous pemphigoid (BP) with antibodies against the B3 subunit of laminin 332 after the development of graft-versus-host disease (GVHD). She was diagnosed with recurrent acute lymphoblastic leukemia at 40 years of age and underwent two rounds of allogeneic peripheral blood stem cell transplantations (PBST). Two and a half years after the second PBST, multiple tense blisters appeared on her face, hands, and lower legs. The diagnosis of BP was based on hematoxylin eosin and immunofluorescence staining and immunoblotting analyses...
October 15, 2023: Dermatology Online Journal
https://read.qxmd.com/read/38476807/advancements-in-heart-transplantation-donor-derived-cell-free-dna-as-next-generation-biomarker
#27
REVIEW
Pawel Borkowski, Nikita Singh, Natalia Borkowska
Heart failure, particularly in its advanced stages, significantly impacts quality of life. Despite progress in Guideline-Directed Medical Therapy (GDMT) and invasive treatments, heart transplantation (HT) remains the primary option for severe cases. However, complications such as graft rejection present significant challenges that necessitate effective monitoring. Endomyocardial biopsy (EMB) is the gold standard for detecting rejection, but its invasive nature, associated risks, and healthcare costs have shifted interest in non-invasive techniques...
February 2024: Curēus
https://read.qxmd.com/read/38469823/prospects-for-the-application-of-transplantation-with-human-amniotic-membrane-epithelial-stem-cells-in-systemic-lupus-erythematosus
#28
REVIEW
Liping Xu, Qiaoding Dai, Yan Zhang, Na Lin, Lina Ji, Xinwei Song
Systemic lupus erythematosus (SLE) is a multi-organ and systemic autoimmune disease characterized by an imbalance of humoral and cellular immunity. The efficacy and side effects of traditional glucocorticoid and immunosuppressant therapy remain controversial. Recent studies have revealed abnormalities in mesenchymal stem cells (MSCs) in SLE, leading to the application of bone marrow-derived MSCs (BM-MSCs) transplantation technique for SLE treatment. However, autologous transplantation using BM-MSCs from SLE patients has shown suboptimal efficacy due to their dysfunction, while allogeneic mesenchymal stem cell transplantation (MSCT) still faces challenges, such as donor degeneration, genetic instability, and immune rejection...
2024: Cell Transplantation
https://read.qxmd.com/read/38468191/close-contacts-of-xenograft-recipients-ethical-considerations-due-to-risk-of-xenozoonosis
#29
JOURNAL ARTICLE
Daniel J Hurst, Luz Padilla, Daniel Rodger, Tamar Schiff, David K C Cooper
With decades of pre-clinical studies culminating in the recent clinical application of xenotransplantation, it would appear timely to provide recommendations for operationalizing oversight of xenotransplantation clinical trials. Ethical issues with clinical xenotransplantation have been described for decades, largely centering on animal welfare, the risks posed to the recipient, and public health risks posed by potential spread of xenozoonosis. Much less attention has been given to considerations relating to potentially elevated risks faced by those who may care for or otherwise have close contact with xenograft recipients...
2024: Xenotransplantation
https://read.qxmd.com/read/38465648/cardiovascular-management-of-patients-undergoing-hematopoietic-stem-cell-transplantation-from-pretransplantation-to-survivorship-a-scientific-statement-from-the-american-heart-association
#30
REVIEW
Salim S Hayek, Vlad G Zaha, Carmel Bogle, Anita Deswal, Amelia Langston, Seth Rotz, Alexi Vasbinder, Eric Yang, Tochukwu Okwuosa
Hematopoietic stem cell transplantation can cure various disorders but poses cardiovascular risks, especially for elderly patients and those with cardiovascular diseases. Cardiovascular evaluations are crucial in pretransplantation assessments, but guidelines are lacking. This American Heart Association scientific statement summarizes the data on transplantation-related complications and provides guidance for the cardiovascular management throughout transplantation. Hematopoietic stem cell transplantation consists of 4 phases: pretransplantation workup, conditioning therapy and infusion, immediate posttransplantation period, and long-term survivorship...
March 11, 2024: Circulation
https://read.qxmd.com/read/38465031/comprehensive-review-of-urinary-tract-infections-in-renal-transplant-recipients-clinical-insights-and-management-strategies
#31
REVIEW
Vidhi Bharuka, Revat Meshram, Pratiksha K Munjewar
Urinary tract infections (UTIs) pose a significant challenge in the care of renal transplant recipients. This comprehensive review explores this population's multifaceted landscape of UTIs, emphasizing the importance of early diagnosis and tailored management strategies. Renal transplant recipients face an elevated risk of UTIs due to immunosuppression, altered urinary tract anatomy, and complex comorbidities. Complications of UTIs can lead to graft dysfunction and systemic illness, underscoring the need for effective management...
February 2024: Curēus
https://read.qxmd.com/read/38463579/non-alcoholic-fatty-liver-disease-pathogenesis-and-models
#32
REVIEW
Hanxiang Zhong, Jiayong Dong, Liye Zhu, Jiaxi Mao, Junfeng Dong, Yuanyu Zhao, You Zou, Meng Guo, Guoshan Ding
Non-alcoholic fatty liver disease (NAFLD) is a complex disease characterized by a massive accumulation of lipids in the liver, with a continuous progression of simple steatosis, non-alcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma. Non-alcoholic fatty liver disease is associated with obesity, insulin resistance, and metabolic syndrome; it is a severe public health risk and is currently the most common liver disease of the world. In addition to the fatty infiltration of the liver in non-alcoholic fatty liver disease patients, the field of liver transplantation faces similar obstacles...
2024: American Journal of Translational Research
https://read.qxmd.com/read/38462318/medical-therapy-and-monitoring-in-adult-congenital-heart-disease-heart-failure
#33
REVIEW
Jeremy Nicolarsen, James Mudd, Andrew Coletti
Heart failure (HF) in adult congenital heart disease (ACHD) is an increasingly common problem facing ACHD and advanced heart disease and transplant providers. Patients are highly nuanced, and therapies are poorly studied. Standard HF medications are often used in patients who are not targets of large clinical trials. HF management in this data-free zone requires focused, comprehensive team-based care and close follow-up and communication with patients.
April 2024: Heart Failure Clinics
https://read.qxmd.com/read/38460948/physical-exercise-a-polypill-against-chronic-kidney-disease
#34
JOURNAL ARTICLE
Pedro L Valenzuela, Adrián Castillo-García, Gonzalo Saco-Ledo, Alejandro Santos-Lozano, Alejandro Lucia
We are currently facing a pandemic of physical inactivity that might contribute to the growing prevalence of chronic kidney disease (CKD). Here, we summarize currently available evidence on the association between physical activity and CKD, and also review the effects of exercise intervention in affected patients. Physical activity/exercise might act as a polypill against CKD, preventing its development or even exerting beneficial effects once it is established (i.e. improvements in patients' physical fitness and cardiovascular risk, as well as in kidney function)...
March 9, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38460391/what-factors-contribute-to-cancer-survivors-self-management-skills-a-cross-sectional-observational-study
#35
JOURNAL ARTICLE
Janet M J Been-Dahmen, Heleen van der Stege, Wendy H Oldenmenger, Cora Braat, Mariska C M van der Lans, Mark Scheper, AnneLoes van Staa, Erwin Ista
PURPOSE: Many cancer survivors, facing the consequences of their disease and its treatment, have medical and supportive aftercare needs. However, limited knowledge exists regarding the relationship between support needs and survivors' self-management skills. The study aim is to explore factors contributing to cancer survivors' self-management skills. METHODS: A cross-sectional study was conducted among cancer survivors (n = 277) of two outpatient oncology clinics at a university hospital in the Netherlands...
February 23, 2024: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://read.qxmd.com/read/38459094/a-proof-of-principle-for-decontamination-of-transplantation-kidney-through-uv-c-exposition-of-the-perfusate-solution
#36
JOURNAL ARTICLE
L C Goenaga-Mafud, J D Vollet-Filho, C Costa, N M Inada, A S Netto, C Kurachi, V S Bagnato
Kidney transplantation is a common yet highly demanding medical procedure worldwide, enhancing the quality of life for patients with chronic kidney disease. Despite its prevalence, the procedure faces a shortage of available organs, partly due to contamination by microorganisms, leading to significant organ disposal. This study proposes utilizing photonic techniques associated with organ support machines to prevent patient contamination during kidney transplantation. We implemented a decontamination system using ultraviolet-C (UV-C) irradiation on the preservation solution circulating through pigs' kidneys between harvest and implant...
March 8, 2024: Scientific Reports
https://read.qxmd.com/read/38458556/revolutionizing-pancreatic-islet-organoid-transplants-improving-engraftment-and-exploring-future-frontiers
#37
REVIEW
Noella Abraham, Tejaswini Kolipaka, Giriraj Pandey, Mansi Negi, Dadi A Srinivasarao, Saurabh Srivastava
Type-1 Diabetes Mellitus (T1DM) manifests due to pancreatic beta cell destruction, causing insulin deficiency and hyperglycaemia. Current therapies are inadequate for brittle diabetics, necessitating pancreatic islet transplants, which however, introduces its own set of challenges such as paucity of donors, rigorous immunosuppression and autoimmune rejection. Organoid technology represents a significant stride in the field of regenerative medicine and bypasses donor-based approaches. Hence this article focuses on strategies enhancing the in vivo engraftment of islet organoids (IOs), namely vascularization, encapsulation, immune evasion, alternative extra-hepatic transplant sites and 3D bioprinting...
March 6, 2024: Life Sciences
https://read.qxmd.com/read/38457773/haemoglobin-bart-s-hydrops-fetalis-charting-the-past-and-envisioning-the-future
#38
JOURNAL ARTICLE
Ali Amid, Siyu Liu, Christian Babbs, Douglas R Higgs
Haemoglobin Bart's hydrops fetalis syndrome (BHFS) represents the most severe form of α-thalassaemia, arising from deletion of the duplicated α-globin genes from both alleles. The absence of α-globin leads to the formation of non-functional haemoglobin Bart's (γ4) or haemoglobin H (HbH: β4) resulting in severe anaemia, tissue hypoxia, and, in some cases, variable congenital or neurocognitive abnormalities. BHFS is the most common cause of hydrops fetalis in Southeast Asia; however, owing to global migration, the burden of this condition is increasing worldwide...
March 8, 2024: Blood
https://read.qxmd.com/read/38451687/amniotic-membrane-transplantation-for-neurotrophic-corneal-ulcers
#39
JOURNAL ARTICLE
Anna Carolina Badotti Linhares, Ana Caroline Martinelli, Mariela Regina Dalmarco Ghem, Paula Basso Dias, Daniel Wasilewski
PURPOSE: To evaluate the clinical results of cryopreserved amniotic membrane transplantation as a treatment option for refractory neurotrophic corneal ulcers. METHODS: This prospective study included 11 eyes of 11 patients who underwent amniotic membrane transplantation for the treatment of refractory neurotrophic corneal ulcers at Hospital de Clínicas da Universidade Federal do Paraná, in the city of Curitiba, from May 2015 to July 2021. Patients underwent different surgical techniques in which the amniotic membrane was applied with the epithelium facing upward to promote corneal re-epithelialization...
2024: Arquivos Brasileiros de Oftalmologia
https://read.qxmd.com/read/38442703/advancements-in-hla-typing-techniques-and-their-impact-on-transplantation-medicine
#40
REVIEW
Jeethu Anu Geo, Reem Ameen, Salem Al Shemmari, Jibu Thomas
HLA typing serves as a standard practice in hematopoietic stem cell transplantation to ensure compatibility between donors and recipients, preventing the occurrence of allograft rejection and graft-versus-host disease. Conventional laboratory methods that have been widely employed in the past few years, including Sequence-Specific Primer PCR and Sequencing Based Typing (SBT), currently face the risk of becoming obsolete. This risk stems not only from the extensive diversity within HLA genes but also from the rapid advancement of Next Generation Sequencing and third-generation sequencing technologies...
March 5, 2024: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
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