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Face transplantation

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https://www.readbyqxmd.com/read/29786002/eyelid-kaposi-sarcoma-in-an-hiv-negative-patient
#1
Jose Manuel Abalo-Lojo, Ihab Abdulkader-Nallib, Laura Martínez Pérez, Francisco Gonzalez
Kaposi sarcoma (KS) is a low-grade, multicentric vascular neoplasm. Most commonly, it involves the skin, but it can occur at any site on the body. The cutaneous lesions are often located on the lower legs, genitalia, oral mucosa, and face. KS is categorized in four different types: classic, endemic, epidemic or AIDS associated, and transplantation associated. We report a case of HIV-negative, classic KS located on the eyelid. The eyelid lesion was completely excised, and after a 1-year follow-up, no recurrences were observed...
June 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29785719/children-s-experiences-and-expectations-of-kidney-transplantation-a-qualitative-interview-study
#2
Rachael C Walker, Derisha Naicker, Tonya Kara, Suetonia C Palmer
RATIONALE AND OBJECTIVE: Kidney transplantation offers improved quality of life and life expectancy compared with dialysis for children. This study aims to understand the experiences and expectations of children during the kidney transplantation process to inform clinical care. STUDY DESIGN: Face-to-face, semi-structured interviews. SETTING AND PARTICIPANTS: We interviewed 13 children and adolescents aged between 7 and 17 years old in New Zealand who had received a kidney transplantation...
May 21, 2018: Nephrology
https://www.readbyqxmd.com/read/29782184/the-growth-of-preantral-follicles-and-the-impact-of-different-supplementations-and-circumstances-a-review-study-with-focus-on-bovine-and-human-preantral-follicles
#3
Zahra Rajabi, Zunair Khokhar, Hossein Yazdekhasti
One of the most important concerns cancer survivors face is fertility. Current treatment modalities often result in damage to the reproductive system. Different options have been proposed to preserve the fertility of affected women, and many attempts have been made to improve their chance of childbearing after therapy. Cryopreservation of ovarian tissue and follicles before the onset of cancer treatment and then either transplantation of ovarian tissue or culture of ovarian tissue and individual follicles in vitro is a commonly cited approach...
May 21, 2018: Cellular Reprogramming
https://www.readbyqxmd.com/read/29774622/pediatric-marginal-donor-hearts-trends-in-us-national-use-2005-2014
#4
Adam K Morrison, Charitha Gowda, Dmitry Tumin, Christina M Phelps, Don Hayes, Joseph Tobias, Robert J Gajarski, Deipanjan Nandi
Pediatric patients awaiting heart transplant face high mortality rates due to donor organ shortages, including non-use of marginal donor hearts. We examined national trends in pediatric marginal donor heart use over time. UNOS data were queried for heart donors <18 years from 2005 to 2014. The proportion of donor hearts considered marginal was determined using previously cited marginal characteristics: left ventricular ejection fraction (LVEF) <50%, use of ≥2 inotropes, cerebrovascular death, CDC high-risk status, and eGFR < 30 mL/min/1...
May 17, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29771842/perceived-esthetic-outcomes-of-face-transplantation-a-survey-of-the-general-public
#5
Alessandra E Cabrera, Laura L Kimberly, Rami S Kantar, Elisa K Atamian, Amit K Manjunath, Lauren K Rangel, Michelle W McQuinn, J Rodrigo Diaz-Siso, Eduardo D Rodriguez
Facial transplantation (FT) has attracted the interest of individuals with facial disfigurement as a path to social reintegration. The perception among face transplant recipients and the reconstructive surgery community appears to be that superior functional and esthetic outcomes can be obtained with FT compared to autologous reconstruction (AR). Although lifelong immunosuppression adds well-known risks to FT, its benefits have proven difficult to quantify, especially because of its non-life-saving nature. Evidence that the general public perceives facial allograft recipients as less disfigured than AR patients may dramatically alter the currently accepted risk/benefit ratio of this novel procedure...
May 15, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29771838/face-transplantation-an-update-for-the-united-states-trauma-system
#6
Scott J Farber, Rami S Kantar, J Rodrigo Diaz-Siso, Eduardo D Rodriguez
Face transplantation has evolved over the last 12 years into a safe and feasible reconstructive solution, with good aesthetic and functional outcomes for patients with severe facial defects who are not amenable to reconstruction through conventional and autologous approaches. Among patients who underwent face transplantation to date, a significant proportion did so following trauma, mostly ballistic and thermal injuries. It is therefore important for trauma surgeons who deal with these injuries regularly to be familiar with the literature on face transplantation following traumatic injuries...
May 15, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29750725/face-transplant-status-of-current-supporting-technology-to-plan-and-perform-the-operation-and-monitor-the-graft-in-the-postoperative-period
#7
Edward J Caterson, Justin C McCarty
Face transplant has rapidly advanced since the first operation in 2005, and to date, 40 partial or full-face transplants have been performed. The safety and efficacy of this operation are aided at all phases by supporting technologies. These include advanced imaging techniques to plan the operation, devices to monitor the flap in the immediate perioperative period, and noninvasive imaging and serum markers to monitor for acute and chronic rejection. Some of the technologies, such as those used in the immediate perioperative period, have extensive evidence supporting their use, whereas those to detect acute or chronic rejection remain investigational...
May 10, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29750131/tissue-engineering-toward-organ-specific-regeneration-and-disease-modeling
#8
Christian Mandrycky, Kiet Phong, Ying Zheng
Tissue engineering has been recognized as a translational approach to replace damaged tissue or whole organs. Engineering tissue, however, faces an outstanding knowledge gap in the challenge to fully recapitulate complex organ-specific features. Major components, such as cells, matrix, and architecture, must each be carefully controlled to engineer tissue-specific structure and function that mimics what is found in vivo. Here we review different methods to engineer tissue, and discuss critical challenges in recapitulating the unique features and functional units in four major organs-the kidney, liver, heart, and lung, which are also the top four candidates for organ transplantation in the USA...
September 2017: MRS Communications
https://www.readbyqxmd.com/read/29746324/extracorporeal-perfusion-in-vascularized-composite-allotransplantation-current-concepts-and-future-prospects
#9
Maximilian Kueckelhaus, Flemming Puscz, Alexander Dermietzel, Mehran Dadras, Sebastian Fischer, Nicco Krezdorn, Bohdan Pomahac, Tobias Hirsch
Severe injuries of the face and limbs remain a major challenge in today's reconstructive surgery. Vascularized composite allotransplantation (VCA) has emerged as a promising approach to restore these defects. Yet, there are major obstacles preventing VCA from broad clinical application. Two key restrictions are (1) the graft's limited possible ischemia time, keeping the potential donor radius extremely small, and (2) the graft's immunogenicity, making extensive lifelong monitoring and immunosuppressive treatment mandatory...
June 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29744913/cartilage-hair-hypoplasia-with-cutaneous-lymphomatoid-granulomatosis
#10
D Sathishkumar, J E Gach, M Ogboli, M Desai, T Cole, W Högler, J Motwani, A Norton, B Morland, I Colmenero
Cartilage-hair hypoplasia (CHH) is an autosomal recessive chondrodysplasia characterized by short-stature, sparse hair and impaired cellular immunity. We describe a young girl who was diagnosed with CHH based on the findings of recurrent infections, short stature with metaphyseal chondrodysplasia, and a confirmed bi-allelic RMRP gene mutation. At 13 years, the patient developed an Epstein-Barr virus (EBV)-driven lymphoproliferative disorder involving the lung, which responded partially to chemotherapy. Simultaneously, she developed multiple indurated plaques involving her face, which had histological findings of granulomatous inflammation and EBV-associated low-grade lymphomatoid granulomatosis...
May 10, 2018: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29742420/self-condensation-culture-enables-vascularization-of-tissue-fragments-for-efficient-therapeutic-transplantation
#11
Yoshinobu Takahashi, Keisuke Sekine, Tatsuya Kin, Takanori Takebe, Hideki Taniguchi
Clinical transplantation of tissue fragments, including islets, faces a critical challenge because of a lack of effective strategies that ensure efficient engraftment through the timely integration of vascular networks. We recently developed a complex organoid engineering method by "self-condensation" culture based on mesenchymal cell-dependent contraction, thereby enabling dissociated heterotypic lineages including endothelial cells to self-organize in a spatiotemporal manner. Here, we report the successful adaptation of this method for generating complex tissues from diverse tissue fragments derived from various organs, including pancreatic islets...
May 8, 2018: Cell Reports
https://www.readbyqxmd.com/read/29713873/post-et-and-post-pv-myelofibrosis-updates-on-a-distinct-prognosis-from-primary-myelofibrosis
#12
REVIEW
Francesco Passamonti, Barbara Mora, Daniela Barraco, Margherita Maffioli
PURPOSE OF REVIEW: The purpose of this review is to help doctors in the management of patients with post-polycythemia (PPV) and post-essential thrombocythemia (PET) myelofibrosis (MF) facing diagnostic criteria, prognostication, and treatment possibilities. RECENT FINDINGS: Diagnostic criteria of primary myelofibrosis (PMF) have been recently updated from the WHO classification. A clear-cut distinction between pre-fibrotic and overt PMF has been done. Concerning PPV and PET MF, the criteria come from 2008...
April 30, 2018: Current Hematologic Malignancy Reports
https://www.readbyqxmd.com/read/29709112/a-five-year-study-of-the-efficacy-of-purified-cd34-cell-therapy-for-angiitis-induced-no-option-critical-limb-ischemia
#13
Yuan Fang, Zheng Wei, Bin Chen, Tianyue Pan, Shiyang Gu, Peng Liu, Daqiao Guo, Xin Xu, Junhao Jiang, Jue Yang, Zhenyu Shi, Ting Zhu, Yun Shi, Yifan Liu, Zhihui Dong, Weiguo Fu
Angiitis-induced critical limb ischemia (AICLI) patients constitute a remarkable proportion of no-option critical limb ischemia (CLI) patients. Stem cell therapy has become an innovative and promising option for no-option CLI patients. As one of these promising stem cell therapies, purified CD34+ cell transplantation (PuCeT) has shown favorable short-term results. However, the long-term efficacy of PuCeT has yet to be reported. This study evaluates the long-term efficacy of PuCeT in AICLI patients. Twenty-seven AICLI patients were enrolled from May 2009 to December 2011...
April 30, 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29706122/a-qualitative-analysis-of-south-african-health-professionals-discussion-on-distrust-and-unwillingness-to-refer-organ-donors
#14
Harriet Rosanne Etheredge, Claire Penn, Jennifer Watermeyer
INTRODUCTION: South Africa is faced with very low deceased organ donor numbers. Often, sociocultural practices, which are thought to be fundamentally opposed to deceased organ donation, are hailed as the cause. However, other factors such as context, social perceptions, and clinical environment may play a role. AIM: The aim of this article is to present research that explored communication in organ transplant and identified barriers to organ donation decisions in a province of South Africa...
January 1, 2018: Progress in Transplantation
https://www.readbyqxmd.com/read/29702179/state-of-the-art-in-pediatric-lung-transplantation
#15
Timothy S Lancaster, Pirooz Eghtesady
Pediatric lung transplantation is a highly specialized therapy for end stage pulmonary disease in children, performed in only a handful of transplant centers around the world. Advancement in the field has been made on many fronts in recent years, including in public policy and organ allocation strategies, donor selection and management, emerging technologies for donor lung rehabilitation and bridge-to-transplant support of listed candidates, and ongoing refinement of surgical techniques. Despite this progress, children continue to suffer discrepant waitlist mortality and longer waiting times than their adult counterparts, and face special challenges of donor availability and size matching...
April 24, 2018: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29701240/a-10-year-longitudinal-follow-up-study-of-a-uk-paediatric-transplant-population-to-assess-for-skin-cancer
#16
S H Foo, P G Nightingale, P Gazzani, E Bader, M Ogboli, A Martin-Clavijo, D V Milford, D A Kelly, C Moss, M A Thomson
BACKGROUND: Our earlier study published in 2004 1 found no skin cancer in a cohort of paediatric organ transplant recipients (POTRs) 5 to 16 years post-transplantation. We re-evaluated the same cohort 10 years later. OBJECTIVES: To determine the prevalence of premalignant and malignant skin lesions and identify known risk factors associated with melanocytic naevi in a UK paediatric transplant population. METHODS: Ninety eight POTRs from the original 2004 study were invited to participate in this longitudinal follow-up study...
April 27, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29684247/tr1-cell-immunotherapy-promotes-transplant-tolerance-via-de-novo-tr1-cell-induction-in-mice-and-is-safe-and-effective-during-acute-viral-infection
#17
Tatiana Jofra, Roberta Di Fonte, Giuseppe Galvani, Mirela Kuka, Matteo Iannacone, Manuela Battaglia, Georgia Fousteri
Tr1 cell therapy is considered an emerging approach to improve transplant tolerance and enhance allogeneic graft survival. However, it remains unclear how Tr1 cells promote transplant tolerance and whether they will be safe and stable in the face of an acute viral infection. By employing a mouse model of pancreatic islet transplantation, we report that Tr1 cell therapy promoted transplant tolerance via de novo induction of Tr1 cells in the recipients. Acute viral infection with lymphocytic choriomeningitis virus (LCMV) had no impact on Tr1 cell number and function, neither on the Tr1 cells infused nor on the ones induced, and that was reflected in the robust maintenance of the graft...
April 23, 2018: European Journal of Immunology
https://www.readbyqxmd.com/read/29681947/synergistic-integration-of-mesenchymal-stem-cells-and-hydrostatic-pressure-in-the-expansion-and-maintenance-of-human-hematopoietic-progenitor-cells
#18
Yun Gyeong Kang, Jee-Yeong Jeong, Tae-Hee Lee, Ho Sup Lee, Jung-Woog Shin
Ex vivo expansion of hematopoietic stem/progenitor cell (HSPC) has been investigated to improve the clinical outcome of HSPC transplantation. However, ex vivo expansion of HSPCs still faces a major obstacle in that HPSCs tend to differentiate when proliferating. Here, we cocultured HSPCs with mesenchymal stem cells (MSCs) and divided the HSPCs into two fractions according to whether they came into adherent to MSCs or not. Additionally, we used hydrostatic pressure (HP) to mimic the physical conditions in vivo ...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29671724/facial-disfigurement-and-identity-a-review-of-the-literature-and-implications-for-facial-transplantation
#19
William J Rifkin, Rami S Kantar, Safi Ali-Khan, Natalie M Plana, J Rodrigo Diaz-Siso, Manos Tsakiris, Eduardo D Rodriguez
Facial disfigurement can significantly affect personal identity and access to social roles. Although conventional reconstruction can have positive effects with respect to identity, these procedures are often inadequate for more severe facial defects. In these cases, facial transplantation (FT) offers patients a viable reconstructive option. However, FT's effect on personal identity has been less well examined, and ethical questions remain regarding the psychosocial ramifications of the procedure. This article reviews the literature on the different roles of the face as well as psychological and social effects of facial disfigurement...
April 1, 2018: AMA Journal of Ethics
https://www.readbyqxmd.com/read/29671081/type-2-diabetes-mellitus-the-metabolic-syndrome-and-its-components-in-adult-survivors-of-acute-lymphoblastic-leukemia-and-hematopoietic-stem-cell-transplantations
#20
REVIEW
Bella Bielorai, Orit Pinhas-Hamiel
PURPOSE OF REVIEW: A growing number of pediatric acute lymphoblastic leukemia (ALL) and hematopoietic stem cell transplantation (HSCT) survivors reach adulthood and face long-term health-related problems. We review risk factors and the prevalence of the metabolic syndrome (MetS), a cluster of obesity-related comorbidities, including abdominal obesity, atherogenic dyslipidemia, elevated blood pressure, impaired glucose metabolism, and type 2 diabetes in ALL and HSCT survivors. RECENT FINDINGS: Components of the MetS are already detected during the first year of ALL maintenance therapy and significantly worsen over time...
April 18, 2018: Current Diabetes Reports
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