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Face transplantation

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https://www.readbyqxmd.com/read/29333321/periodontal-wound-healing-following-reciprocal-autologous-root-transplantation-in-class-iii-furcation-defects
#1
Naoshi Takeuchi, Yoshinori Shirakata, Yukiya Shinohara, Kotaro Sena, Kazuyuki Noguchi
Purpose: Furcation involvement in the molars is difficult to treat, and has been recognized as a risk factor for tooth loss. Although periodontal regenerative therapies, including guided tissue regeneration and various types of bone grafts, have been applied to furcation defects, the effects of these treatments are limited, especially in large class III furcation defects. The purpose of this pilot study was to investigate the effect of reciprocal autologous root transplantation on periodontal wound healing and regeneration in class III furcation defects in dogs...
December 2017: Journal of Periodontal & Implant Science
https://www.readbyqxmd.com/read/29330399/geriatric-assessment-and-quality-of-life-in-older-patients-considered-for-allogeneic-hematopoietic-cell-transplantation-a-prospective-risk-factor-and-serial-assessment-analysis
#2
Barbara Deschler, Gabriele Ihorst, Susanne Schnitzler, Hartmut Bertz, Juergen Finke
Allogeneic hematopoietic cell transplantation (alloHCT) in older patients requires the weighing of risks and benefits for this potentially curative treatment while facing age-related limitations. Comprehensive geriatric and quality of life (EORTC QLQ C-30) assessements (CGA/QOL) in addition to disease-specific data were obtained in 108 consecutive patients (≥60 years) pre-HCT, at day +30, +100, and +180. Median follow-up of 106 patients alive at alloHCT was 43.5 months, median age 66 years (range 60-78). Eighty-six (81...
January 12, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29329530/design-and-evaluation-of-a-mobile-application-to-assist-the-self-monitoring-of-the-chronic-kidney-disease-in-developing-countries
#3
Alvaro Sobrinho, Leandro Dias da Silva, Angelo Perkusich, Maria Eliete Pinheiro, Paulo Cunha
BACKGROUND: The chronic kidney disease (CKD) is a worldwide critical problem, especially in developing countries. CKD patients usually begin their treatment in advanced stages, which requires dialysis and kidney transplantation, and consequently, affects mortality rates. This issue is faced by a mobile health (mHealth) application (app) that aims to assist the early diagnosis and self-monitoring of the disease progression. METHODS: A user-centered design (UCD) approach involving health professionals (nurse and nephrologists) and target users guided the development process of the app between 2012 and 2016...
January 12, 2018: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/29328459/%C3%AE-solanine-enhances-the-chemosensitivity-of-esophageal-cancer-cells-by-inducing-microrna%C3%A2-138-expression
#4
Jianbo Wu, Li Wang, Xinhui Du, Qianqian Sun, Yuanyuan Wang, Min Li, Wenqiao Zang, Kangdong Liu, Guoqiang Zhao
Esophageal cancer is a common malignant tumor worldwide. Inherent and acquired drug resistance are the major challenges faced in anticancer chemotherapy. This study aimed to explore the effects of α-solanine in regards to the chemosensitivity of esophageal cancer cells. We found that α-solanine enhanced the sensitivity of EC9706 and KYSE30 cells to 5-flurouracil (5-FU) and cisplatin (Cis) by promoting drug-induced apoptosis. qRT-PCR and western blotting results showed that α-solanine treatment promoted miR-138 expression and decreased survivin expression in EC9706 and KYSE30 cells...
January 4, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29327399/plga-mpeg-nanoparticles-loaded-with-melatonin-protect-adipose-derived-stem-cells-transplanted-in-infarcted-heart-tissue
#5
Qiang Ma, Junjie Yang, Xu Huang, Weisheng Guo, Sulei Li, Hao Zhou, Jingwei Li, Yundai Chen
Stem cell transplantation is a promising therapeutic strategy for myocardial infarction. However, transplanted cells face low survival rates due to oxidative stress and the inflammatory microenvironment in ischemic heart tissue. Melatonin has been used as a powerful endogenous antioxidant to protect cells from oxidative injury. However, melatonin cannot play a long lasting effect against the hostile microenvironment. Nano drug delivery carriers have the ability to protect the loaded drug from degradation in physiological environments in a controlled manner, which results in longer effects and decreased side effects...
January 12, 2018: Stem Cells
https://www.readbyqxmd.com/read/29322633/preclinical-evaluation-of-melanocyte-transplantation-by-chitosan-based-melanocyte-spheroid-patch-to-skin-prepared-by-controlled-sunburn-blistering
#6
Sabrina Mai-Yi Fan, Po-Hua Chen, Yu-Ting Tseng, Jin-Bon Hong, Wannhsin Chen, Tsen-Fang Tsai, Sung-Jan Lin
Transplantation of autologous cultured melanocytes as cell suspension has been used for the treatment of vitiligo. The recipient site is often prepared by laser-mediated dermabrasion. Such procedures encounter disadvantages including prolonged transplantation duration, unsecured cell adherence to lesional skin and potential scarring. To improve this, here we propose a method by preparing recipient sites before transplantation by psoralen and ultraviolet A (PUVA)-induced sunburn followed by transplanting cells with a chitosan-based melanocyte spheroid patch...
January 10, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29316061/pediatric-kidney-transplantation-and-mortality-distance-to-transplant-center-matters
#7
Bonnie Cao, Joel T Adler, Yanik J Bababekov, James F Markmann, David C Chang, Heidi Yeh
Distance from pediatric kidney transplant centers may be a significant barrier in accessing care for patients and families, particularly due to the lower number of pediatric kidney transplant centers compared with the number of adult centers. We performed a retrospective cohort study using data from the Scientific Registry of Transplant Recipients to determine the effect of distance on pediatric kidney transplant waitlist outcomes. We found that distance did not play a role in the likelihood of transplantations for patients who were placed on the waitlist...
January 7, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29303865/facing-a-new-face-an-interpretative-phenomenological-analysis-of-the-experiences-of-a-blind-face-transplant-patient-and-his-partner
#8
Hannelore Hendrickx, Phillip N Blondeel, Hanna Van Parys, Nathalie A Roche, Patrick C Peeters, Hubert F Vermeersch, Xavier Rogiers, Kristiane Van Lierde, Gilbert M D Lemmens
Increasing evidence points to good functional, aesthetic, and psychosocial outcomes after face transplantation. However, research investigating how patients and their families subjectively experience the transplantation process is lacking thus far. This study aims to investigate the personal experiences of a blind face transplant patient and his partner. In-depth interviews exploring different experiences were conducted with both partners separately 20 months after face transplantation. The interviews were analyzed using interpretative phenomenological analysis...
January 4, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29285533/scaffold-assisted-artificial-hair-implantation-in-a-rat-model
#9
Joshua K Au, Miguel Fernando Palma Diaz, Tara Aghaloo, Maie A St John
Importance: Current treatments for alopecia with autograft hair transplantation face limitations that may preclude complete hair restoration and leave patients with donor site scars. Scaffold assisted artificial hair implantation as demonstrated in a rat model may provide an adjunct for hair restoration without donor site morbidity. Objective: To design and create porous high-density polyethylene (PHDPE) and expanded polytetrafluoroethylene (ePTFE) hair-bearing scaffolds and evaluate their biocompatibility in a rat model...
December 28, 2017: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/29280879/the-public-face-of-transplantation-the-potential-of-education-to-expand-the-face-donor-pool
#10
Natalie M Plana, Laura L Kimberly, Brendan Parent, Kimberly S Khouri, J Rodrigo Diaz-Siso, Elise M Fryml, Catherine C Motosko, Daniel J Ceradini, Arthur Caplan, Eduardo D Rodriguez
BACKGROUND: Despite the growing success of facial transplantation, organ donor shortages remain challenging. Educational health campaigns can effectively inform the general public and institute behavioral modifications. A brief educational introduction to facial transplantation may positively influence the public's position on facial donation. METHODS: The authors anonymously surveyed 300 participants, gathering basic demographic information, donor registration status, awareness of facial transplantation, and willingness to donate solid organs and facial allografts...
January 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29272987/the-practicalities-of-establishing-a-porcine-isolated-heart-model
#11
Warren Pavey, Anthea Raisis, Ben Dunne, Els Van Laeken, Charles Jenkinson, Viji Vincent, Peter Baird, Stuart Prince, Kwok M Ho, Christopher Merry, Ian Gilfillan
BACKGROUND: The isolated heart apparatus is over 100 years old, but remains a useful research tool today. While designs of many large animal systems have been described in the literature, trouble-shooting and refining such a model to yield a stable, workable system has not been previously described. This paper outlines the issues, in tabular form, that our group encountered in developing our own porcine isolated heart rig with the aim of assisting other workers in the field planning similar work...
December 1, 2017: Perfusion
https://www.readbyqxmd.com/read/29260588/upfront-treatment-of-elderly-myeloma-patients-an-overview-and-update
#12
Hussein G Elsayed, Amal S Alabdulwahab
Multiple myeloma is primarily a disease of older age, with a median age of 70 years at diagnosis. Management of the disease in this diverse population is challenging, in the face comorbidities and frailties. Areas covered: This review discusses the management challenges of elderly myeloma patients in view of the current evidence and propose for performing a formal objective assessment of the functional status to guide choice of treatment. Expert commentary: The approval of many antimyeloma medications with various mechanisms of action in the past two decades had sparked the debate about choosing the best combination, duration of therapy, role of transplant and the possibility to cure myeloma after being changed to a chronic disease...
December 20, 2017: Expert Review of Hematology
https://www.readbyqxmd.com/read/29232275/complex-decision-making-in-heart-failure-a-systematic-review-and-thematic-analysis
#13
Aimee V Hamel, Joseph E Gaugler, Carolyn M Porta, Niloufar Niakosari Hadidi
BACKGROUND: Heart failure follows a highly variable and difficult course. Patients face complex decisions, including treatment with implantable cardiac defibrillators, mechanical circulatory support, and heart transplantation. The course of decision-making across multiple treatments is unclear yet integral to providing informed and shared decision-making. Recognizing commonalities across treatment decisions could help nurses and physicians to identify opportunities to introduce discussions and support shared decision-making...
December 11, 2017: Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/29227284/cografting-astrocytes-improves-cell-therapeutic-outcomes-in-a-parkinson-s-disease-model
#14
Jae-Jin Song, Sang-Min Oh, Oh-Chan Kwon, Noviana Wulnansari, Hyun-Seob Lee, Mi-Yoon Chang, Eunsoo Lee, Woong Sun, Sang-Eun Lee, Sunghoe Chang, Heeyoung An, C Justin Lee, Sang-Hun Lee
Transplantation of neural progenitor cells (NPCs) is a potential therapy for treating neurodegenerative disorders, but this approach has faced many challenges and limited success, primarily because of inhospitable host brain environments that interfere with enriched neuron engraftment and function. Astrocytes play neurotrophic roles in the developing and adult brain, making them potential candidates for helping with modification of hostile brain environments. In this study, we examined whether astrocytic function could be utilized to overcome the current limitations of cell-based therapies in a murine model of Parkinson's disease (PD) that is characterized by dopamine (DA) neuron degeneration in the midbrain...
December 11, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29210109/xenotransplantation-back-to-the-future
#15
REVIEW
Raphael P H Meier, Yannick D Muller, Alexandre Balaphas, Philippe Morel, Manuel Pascual, Jörg D Seebach, Leo H Buhler
The field of xenotransplantation has fluctuated between great optimism and doubts over the last 50 years. The initial clinical attempts were extremely ambitious but faced technical and ethical issues that prompted the research community to go back to preclinical studies. Important players left the field due to perceived xenozoonotic risks and the lack of progress in pig-to-non-human-primate transplant models. Initial apparently unsurmountable issues appear now to be possible to overcome due to progress of genetic engineering, allowing the generation of multiple-xenoantigen knockout pigs that express human transgenes and the genome-wide inactivation of porcine endogenous retroviruses...
December 5, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29203260/the-helsinki-face-transplantation-surgical-aspects-and-1-year-outcome
#16
Patrik Lassus, Andrew Lindford, Jyrki Vuola, Leif Bäck, Sinikka Suominen, Karri Mesimäki, Tommy Wilkman, Tuija Ylä-Kotola, Erkki Tukiainen, Hannu Kuokkanen, Jyrki Törnwall
BACKGROUND: Since 2005, at least 38 facial transplantations have been performed worldwide. We herein describe the surgical technique and 1-year clinical outcome in Finland's first face transplant case. METHODS: A 34-year-old male who had a severe facial deformity following ballistic trauma in 1999 underwent facial transplantation at the Helsinki University Hospital on 8th February 2016. Three-dimensional (3D) technology was used to manufacture donor and recipient patient-specific osteotomy guides and a donor face mask...
November 15, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29191294/evolving-areas-in-heart-transplantation
#17
REVIEW
Brittany N Weber, Jon A Kobashigawa, Michael M Givertz
It has been 50 years since Dr. Christiaan Barnard performed the first human-to-human heart transplant in December 1967 in South Africa. Remarkable progress has been made since that time, including changes in surgical techniques, immunosuppression, donor and recipient selection, and post-transplant care. In this paper, we provide a perspective on the changing face of heart transplantation and highlight key evolving areas. Topics that are covered include advances in immunosuppression, screening for acute and chronic rejection, cardiac allograft vasculopathy, and ongoing advancements in cardiac replacement therapy, including xenotransplantation, stem-cell research, tissue engineering, and the total artificial heart...
December 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/29187136/results-of-a-patient-survey-for-assessment-services-in-renal-transplant-patients-with-a-history-of-cancer
#18
Andreas Ihrig, Imad Maatouk, Susanne Fink, Sascha Pahernik, Caner Süsal, Johannes Huber, Markus Hohenfellner, Martin Zeier, Carsten Grüllich
Patients with cancer who require a kidney transplant often face a prolonged time on the waiting list to ensure a sufficient relapse-free time. Patients and relatives were invited to the patient assessment service where they get an individualized risk assessment and a recommendation for transplantation and waiting period directly from an expert panel. We investigated in 31 patients who filled out questionnaires concerning depression, anxiety, distress, and quality of life and were interviewed for their satisfaction, experiences, and circumstances of the counseling...
December 2017: Progress in Transplantation
https://www.readbyqxmd.com/read/29186240/evaluation-of-treatment-response-to-autologous-transplantation-of-noncultured-melanocyte-keratinocyte-cell-suspension-in-patients-with-stable-vitiligo
#19
Mariana Gontijo Ramos, Daniel Gontijo Ramos, Camila Gontijo Ramos
BACKGROUND: Vitiligo is a chronic disease characterized by the appearance of achromic macules caused by melanocyte destruction. Surgical treatments with melanocyte transplantation can be used for stable vitiligo cases. OBJECTIVES: To evaluate treatment response to the autologous transplantation of noncultured epidermal cell suspension in patients with stable vitiligo. METHODS: Case series study in patients with stable vitiligo submitted to noncultured epidermal cell suspension transplantation and evaluated at least once, between 3 and 6 months after the procedure, to observe repigmentation and possible adverse effects...
May 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29185252/multidrug-resistant-or-antimicrobial-resistant-pathogens-alternatives-to-new-antibiotics
#20
Anne-Sophie Brunel, Benoit Guery
For the last few decades, multidrug resistance has become an increasing concern for both Gram-positive and Gram-negative bacteria. The number of new molecules has dramatically decreased and antibiotic resistance is now a priority in the international community. Facing this new threat, a large number of new as well as "old" solutions are now being discussed in the medical community to propose an alternative to antibiotic treatments. A first option is to potentiate the effect of existing molecules through combinations to circumvent the individual molecule resistance...
November 29, 2017: Swiss Medical Weekly
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