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JOURNAL ARTICLE
Margot E Manning, Zachary Fricker
BACKGROUND: Cardiopulmonary resuscitation (CPR) outcomes among patients with cirrhosis are poor, but factors associated with outcomes and provider awareness remain under-evaluated. AIMS: We retrospectively investigated in-hospital CPR mortality among patients with cirrhosis, and, using these results, undertook an educational study among providers to improve knowledge of CPR outcomes and code status in patients with cirrhosis. METHODS: We identified patients with cirrhosis admitted from 2012 to 2022 who underwent CPR at our center; the primary outcome was survival-to-discharge...
April 23, 2024: Digestive Diseases and Sciences
#2
JOURNAL ARTICLE
Katie Brunner, Lydia Weisschuh, Stefan Jobst, Christiane Kugler, Anne Rebafka
Patients with Solid Organ Transplantations (SOTx) face long-term lifestyle adaptations, psychological and social adjustments, and complex self-care regimes to maintain health post-transplant. Self-management (SM) skills represent important aspects of nursing communication with SOTx patients; however, there is potential for SM to be defined narrowly in terms of medication adherence. The study presented here collated the existing definitions in a mixed method review in order to identify SM attributes for this group (including those unique to this population)...
April 17, 2024: Nursing Reports
#3
REVIEW
Maorong Jiang, Muyang Chen, Nana Liu
Peripheral nerve injuries, caused by various reasons, often lead to severe sensory, motor, and autonomic dysfunction or permanent disability, posing a challenging problem in regenerative medicine. Autologous nerve transplantation has been the gold standard in traditional treatments but faces numerous limitations and risk factors, such as donor area denervation, increased surgical complications, and diameter or nerve bundle mismatches. The extracellular matrix (ECM) is a complex molecular network synthesized and released into the extracellular space by cells residing in tissues or organs...
2024: Frontiers in Neurology
#4
REVIEW
Beatrice Xuan Ho, Adrian Kee Keong Teo, Natasha Hui Jin Ng
Human allogeneic pancreatic islet transplantation is a life-changing treatment for patients with severe Type 1 Diabetes (T1D) who suffer from hypoglycemia unawareness and high risk of severe hypoglycemia. However, intensive immunosuppression is required to prevent immune rejection of the graft, that may in turn lead to undesirable side effects such as toxicity to the islet cells, kidney toxicity, occurrence of opportunistic infections, and malignancies. The shortage of cadaveric human islet donors further limits islet transplantation as a treatment option for widespread adoption...
2024: Frontiers in Immunology
#5
JOURNAL ARTICLE
Willa V Cochran, M Veronica Dioverti, Julie Langlee, Lindsay N Barker, Audra Shedeck, Lindsay P Toman, Robin K Avery
Cytomegalovirus (CMV) infection is associated with increased morbidity and mortality in hematopoietic cell transplant (HCT) and solid organ transplant (SOT) recipients, with traditional anti-CMV therapies limited by their associated toxicities and the development of resistance. Clinical providers are often faced with challenging and complicated CMV infections that require multiple courses of antiviral therapies. Increasingly, advanced practice providers (APPs) are playing an important role in the day-to-day management of transplant recipients with CMV infection, including resistant/refractory CMV and other complex CMV syndromes...
April 23, 2024: Annals of Transplantation: Quarterly of the Polish Transplantation Society
#6
REVIEW
Umar Naseef Mohamed Fareez, Syed Ali Arsal Naqvi, Makame Mahmud, Mikail Temirel
The rapid evolution of healthcare and technology has given rise to advancements in the fields of bioprinting, tissue engineering, and regenerative medicine. 3D bioprinting has emerged as an alternative to traditional practices by offering the potential to create functional tissues. Traditional tissue engineering has faced challenges due to irregular cell distribution on scaffolds, limited cell density, and the difficulty of manufacturing patient-specific tissues, which 3D bioprinting overcomes through layer-by-layer fabrication...
April 22, 2024: Advanced Healthcare Materials
#7
REVIEW
Lisa M Christian, Janice K Kiecolt-Glaser, Steve W Cole, Christin E Burd, Annelise A Madison, Stephanie J Wilson, Ashley E Rosko
Multiple myeloma (MM) is an incurable cancer and is the leading indication for autologous hematopoietic stem cell transplantation (HSCT). To be eligible for HSCT, a patient must have a caregiver, as caregivers play a central role in HSCT preparation and recovery. MM patients remain on treatment indefinitely, and thus patients and their caregivers face long-term challenges including the intensity of HSCT and perpetual therapy after transplant. Importantly, both patients and their caregivers show heightened depressive and anxiety symptoms, with dyadic correspondence evidenced and caregivers' distress often exceeding that of patients...
April 19, 2024: Brain, Behavior, and Immunity
#8
JOURNAL ARTICLE
Stuart J Knechtle, Joseph M Ladowski, Jean Kwun
Because of the global shortage of donor kidneys, xenotransplantation emerges as a potential solution for individuals with kidney failure who face challenges in securing a suitable donor kidney. A study featured in this month's issue of Kidney International assesses the kidney physiology of a porcine kidney transplanted into a brain-dead human with kidney failure, demonstrating life-sustaining physiological function for 7 days. Together with preclinical nonhuman primate studies, decedent models provide complementary data for development of clinical kidney xenotransplantation...
May 2024: Kidney International
#9
JOURNAL ARTICLE
Rita Quinteira, Sara Gimondi, Nelson O Monteiro, Rita Sobreiro-Almeida, Laura Lasagni, Paola Romagnani, Nuno M Neves
Kidney regeneration is hindered by the limited pool of intrinsic reparative cells. Advanced therapies targeting renal regeneration have the potential to alleviate the clinical and financial burdens associated with kidney disease. Delivery systems for cells, extracellular vesicles, or growth factors aimed at enhancing regeneration can benefit from vehicles enabling targeted delivery and controlled release. Hydrogels, optimized to carry biological cargo while promoting regeneration, have emerged as promising candidates for this purpose...
April 18, 2024: Acta Biomaterialia
#10
JOURNAL ARTICLE
Tun Wang, Peng Lu, Zicheng Wan, Zhenyu He, Siyuan Cheng, Yang Zhou, Sheng Liao, Mo Wang, Tianjian Wang, Chang Shu
Arteriovenous grafts (AVGs) have emerged as the preferred option for constructing hemodialysis access in numerous patients. Clinical trials have demonstrated that decellularized vascular graft exhibits superior patency and excellent biocompatibility compared to polymer materials; however, it still faces challenges such as intimal hyperplasia and luminal dilation. The absence of suitable animal models hinders our ability to describe and explain the pathological phenomena above and in vivo adaptation process of decellularized vascular graft at the molecular level...
2024: Regenerative Biomaterials
#11
REVIEW
Michalis Hadjiandreou, Georgios Pafitanis, Peter M Butler
Facial transplantations have become a clinical reality as the last reconstructive option in severely disfigured patients. To date, clinical outcomes remain unclear. The purpose of this paper was to analyse the outcomes in facial transplantation (FT) and determine the risks and benefits of FT based on short- and long-term outcomes. An electronic literature search was performed across PubMed, EMBASE and the Cochrane Central Register for Controlled Trials (CENTRAL) databases to capture all the relevant records relating to outcomes in FTs from 2005 to 2021...
February 28, 2024: British Journal of Oral & Maxillofacial Surgery
#12
REVIEW
Richard K Cheng, Michelle M Kittleson, Craig J Beavers, David H Birnie, Ron Blankstein, Paco E Bravo, Nisha A Gilotra, Marc A Judson, Kristen K Patton, Leonie Rose-Bovino
Cardiac sarcoidosis is an infiltrative cardiomyopathy that results from granulomatous inflammation of the myocardium and may present with high-grade conduction disease, ventricular arrhythmias, and right or left ventricular dysfunction. Over the past several decades, the prevalence of cardiac sarcoidosis has increased. Definitive histological confirmation is often not possible, so clinicians frequently face uncertainty about the accuracy of diagnosis. Hence, the likelihood of cardiac sarcoidosis should be thought of as a continuum (definite, highly probable, probable, possible, low probability, unlikely) rather than in a binary fashion...
April 18, 2024: Circulation
#13
JOURNAL ARTICLE
Gianmarco Lombardi, Pietro Manuel Ferraro, Elisa De Tomi, Matteo Bargagli, Andrea Spasiano, Giovanni Gambaro
BACKGROUND AND HYPOTHESIS: Chronic kidney disease (CKD) is a growing global health concern. Recent research has indicated sex disparities in CKD-related complications, yet the impact of sex differences on critical kidney function levels that trigger these complications and mortality remains inadequately documented. METHODS: We investigated sex-specific disparities in CKD-related complications and mortality according to eGFR levels. We analyzed NHANES data spanning from 1999 to 2018, including adult participants with an eGFR of 15-150 ml/min per 1...
April 17, 2024: Nephrology, Dialysis, Transplantation
#14
JOURNAL ARTICLE
Yue Cheng, Yueman Zhang, Peiying Li
Cell therapy and regenerative medicine have made remarkable progress in treating neurodegenerative disorders. Induced pluripotent stem cells (iPSCs) offer a promising source for cell replacement therapies, but their practical application faces challenges due to poor survival and integration after transplantation. Park et al. propose a novel therapeutic strategy involving the co-transplantation of regulatory T cells (Tregs) and iPSC-derived dopamine neurons. This combined approach enhances the survival of transplanted cells and protects against neuroinflammation-induced damage...
April 17, 2024: Journal of Cerebral Blood Flow and Metabolism
#15
JOURNAL ARTICLE
Omosomi Enilama, Cynthia MacDonald, Pearl Thompson, Umair Khan, Selina Allu, Mary Beaucage, Kevin Yau, Matthew J Oliver, Michelle A Hladunewich, Adeera Levin
BACKGROUND: People living with chronic kidney disease (CKD) face an increased risk of severe outcomes such as hospitalization or death from COVID-19. COVID-19 vaccination is a vital approach to mitigate the risk and severity of infection in patients with CKD. Limited information exists regarding the factors that shape COVID-19 vaccine uptake, including health information-seeking behavior and perceptions, within the CKD population. OBJECTIVE: The objectives were to describe among CKD patients, (1) health information-seeking behavior on COVID-19, (2) their capacity to comprehend and trust COVID-19 information from different sources, and (3) their perceptions concerning COVID-19 infection and vaccination...
2024: Canadian Journal of Kidney Health and Disease
#16
Peteh Mehdi Nkebiwe, Jonas D Stevens Lekfeldt, Sarah Symanczik, Cécile Thonar, Paul Mäder, Asher Bar-Tal, Moshe Halpern, Borbala Biró, Klára Bradáčová, Pedro C Caniullan, Krishna K Choudhary, Vincenza Cozzolino, Emilio Di Stasio, Stefan Dobczinski, Joerg Geistlinger, Angelika Lüthi, Beatriz Gómez-Muñoz, Ellen Kandeler, Flora Kolberg, Zsolt Kotroczó, Martin Kulhanek, Filip Mercl, Guy Tamir, Narges Moradtalab, Alessandro Piccolo, Albino Maggio, Dinah Nassal, Magdolna Zita Szalai, Katalin Juhos, Ciprian G Fora, Andreea Florea, Gheorghe Poşta, Karl Fritz Lauer, Brigitta Toth, Pavel Tlustoš, Isaac K Mpanga, Nino Weber, Markus Weinmann, Uri Yermiyahu, Jakob Magid, Torsten Müller, Günter Neumann, Uwe Ludewig, Andreas de Neergaard
Biostimulants (Bio-effectors, BEs) comprise plant growth-promoting microorganisms and active natural substances that promote plant nutrient-acquisition, stress resilience, growth, crop quality and yield. Unfortunately, the effectiveness of BEs, particularly under field conditions, appears highly variable and poorly quantified. Using random model meta-analyses tools, we summarize the effects of 107 BE treatments on the performance of major crops, mainly conducted within the EU-funded project BIOFECTOR with a focus on phosphorus (P) nutrition, over five years...
2024: Frontiers in Plant Science
#17
JOURNAL ARTICLE
Marta Costa Blasco, Claire Doyle, Sophie Diong, Siona Ni Raghallaigh
Biologics have significantly advanced the treatment of inflammatory disorders, including psoriasis. However, their use in immunosuppressed patients, such as those with solid-organ transplants, is less understood. These patients often face dermatological issues, but inflammatory skin diseases are rare due to their immunosuppressive treatments. Our study aims to assess biologics' effectiveness in such immunocompromised patients. We report a case from our institution of a 29-year-old man with a history of psoriasis, who underwent a kidney transplant and later developed erythroderma...
April 16, 2024: Australasian Journal of Dermatology
#18
Qing Sun, Xing Li, Zhihui Zhu, Xiting Xiang, Shu Zhang, Xiaowei Liu, Xiao Long, Tao Zhang
BACKGROUND: Trigeminal trophic syndrome (TTS) is a rare condition caused by damage to the trigeminal nervous system, resulting in sensory disturbances and ulcers on the face. Treating TTS is complex and often requires medical or surgical intervention like flap reconstruction. However, there is limited research on surgical treatments for TTS ulcers. METHODS: We report the case of a 19-year-old man with TTS. We employed an innovative surgical technique involving dual cross-face nerve grafts...
April 15, 2024: Head & Neck
#19
REVIEW
Eranga Wijewickrama, Muhammad Rafiqul Alam, Divya Bajpai, Smita Divyaveer, Arpana Iyengar, Vivek Kumar, Ahad Qayyum, Shankar Prasad Yadav, Manjusha Yadla, Silvia Arruebo, Aminu K Bello, Fergus J Caskey, Sandrine Damster, Jo-Ann Donner, Vivekanand Jha, David W Johnson, Adeera Levin, Charu Malik, Masaomi Nangaku, Ikechi G Okpechi, Marcello Tonelli, Feng Ye, Dibya Singh Shah, Narayan Prasad
The South Asia region is facing a high burden of chronic kidney disease (CKD) with limited health resources and low expenditure on health care. In addition to the burden of CKD and kidney failure from traditional risk factors, CKD of unknown etiologies from India and Sri Lanka compounds the challenges of optimal management of CKD in the region. From the third edition of the International Society of Nephrology Global Kidney Health Atlas (ISN-GKHA), we present the status of CKD burden, infrastructure, funding, resources, and health care personnel using the World Health Organization's building blocks for health systems in the ISN South Asia region...
April 2024: Kidney International Supplements
#20
JOURNAL ARTICLE
Jennifer A Vencill, Janae L Kirsch, Keagan McPherson, Eric Sprankle, Christi A Patten, Kristie Campana, Tabetha Brockman, Carrie Bronars, Christine Hughes, Dennis Gastineau, Shawna L Ehlers
Sexual health concerns are one of the most common late effects facing hematopoietic stem cell transplant (HSCT) survivors. The current study tested whether self-reported depression and anxiety symptoms before transplant were associated with embedded items assessing two specific areas of sexual health-sexual interest and sexual satisfaction-one year post-HSCT. Of the 158 study participants, 41% were diagnosed with a plasma cell disorder (n = 60) and most received autologous transplantation (n = 128; 81%)...
April 14, 2024: Journal of Clinical Psychology in Medical Settings
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