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https://www.readbyqxmd.com/read/29780819/a-comprehensive-review-of-the-pharmacologic-management-of-uterine-leiomyoma
#1
REVIEW
Terrence D Lewis, Minnie Malik, Joy Britten, Angelo Macapagal San Pablo, William H Catherino
Uterine leiomyomata are the most common benign tumors of the gynecologic tract impacting up to 80% of women by 50 years of age. It is well established that these tumors are the leading cause for hysterectomy with an estimated total financial burden greater than $30 billion per year in the United States. However, for the woman who desires future fertility or is a poor surgical candidate, definitive management with hysterectomy is not an optimal management plan. Typical gynecologic symptoms of leiomyoma include infertility, abnormal uterine bleeding (AUB)/heavy menstrual bleeding (HMB) and/or intermenstrual bleeding (IMB) with resulting iron-deficiency anemia, pelvic pressure and pain, urinary incontinence, and dysmenorrhea...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29780590/medical-management-of-esophageal-food-impaction-refractory-to-endoscopic-interventions
#2
Lauren Stemboroski, Ronald Brown, Keyrillos Rizg, James S Scolapio, Miguel Malespin, Silvio W de Melo
Most esophageal food impactions either pass spontaneously or are treated endoscopically. Severe food impactions can require extensive endoscopic therapy that potentially could lead to procedure-related complications. There are few alternate therapies available when endoscopy fails. Traditionally, pharmacologic therapy with glucagon has been performed with varying success. This case report and discussion will outline the management of a complete food impaction and medical therapies available when first-line endoscopic treatment fails...
2018: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/29768354/feasibility-and-effectiveness-of-electrochemical-dermal-conductance-measurement-for-the-screening-of-diabetic-neuropathy-in-primary-care-decoding-study-dermal-electrochemical-conductance-in-diabetic-neuropathy-rationale-and-design
#3
Juan J Cabré, Teresa Mur, Bernardo Costa, Francisco Barrio, Charo López-Moya, Ramon Sagarra, Montserrat García-Barco, Jesús Vizcaíno, Immaculada Bonaventura, Nicolau Ortiz, Gemma Flores-Mateo
Diabetes mellitus is the leading cause of polyneuropathy in the Western world. Diabetic neuropathy is a frequent complication of diabetes and may have great clinical transcendence due to pain and possible ulceration of the lower extremities. It is also a relevant cause of morbidity and mortality in patients with diabetes. Although the cause of polyneuropathy in patients with diabetes is only partially known, it has been associated with chronic hyperglycemia suggesting the possible etiopathogenic implication of advanced glycosylation end products...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29767565/medical-management-of-deep-ulcerative-keratitis-in-cats-13-cases
#4
Michelle G Martin de Bustamante, Kathryn L Good, Brian C Leonard, Steven R Hollingsworth, Sydney G Edwards, Kelly E Knickelbein, Ann E Cooper, Sara M Thomasy, David J Maggs
Case series summary Described are 13 cats diagnosed with deep ulcerative keratitis and successfully managed medically without grafting procedures. Typical treatment involved frequent topical application of serum and antibiotics (usually a fluoroquinolone and a cephalosporin). Seven cats also received systemic antibiotics. Analgesia was achieved using various combinations of topical atropine and systemic buprenorphine, robenacoxib or corticosteroids. Six cats were hospitalized for a median (range) period of 2...
May 1, 2018: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29764908/management-of-endocrine-disease-which-metabolic-procedure-comparing-outcomes-in-sleeve-gastrectomy-and-roux-en-y-gastric-bypass
#5
Adrian T Billeter, Javier de la Garza Herrera, Katharina M Scheurlen, Felix Nickel, Franck Billmann, Beat Müller-Stich
Obesity and its associated comorbidities have become one of the largest challenges for health care in the near future. Conservative therapy for obesity and related comorbidities have a very high failure rate and poor long-term results. Similarly, the conservative and medical management of the majority of metabolic diseases such as type 2 diabetes mellitus are only able to slow down disease progression but have no causal effect on the disease process. Obesity surgery has evolved as a highly effect therapy for severe obesity achieving long-lasting weight loss...
May 15, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29759947/a-simplified-method-to-account-for-wall-motion-in-patient-specific-blood-flow-simulations-of-aortic-dissection-comparison-with-fluid-structure-interaction
#6
Mirko Bonfanti, Stavroula Balabani, Mona Alimohammadi, Obiekezie Agu, Shervanthi Homer-Vanniasinkam, Vanessa Díaz-Zuccarini
Aortic dissection (AD) is a complex and highly patient-specific vascular condition difficult to treat. Computational fluid dynamics (CFD) can aid the medical management of this pathology, yet its modelling and simulation are challenging. One aspect usually disregarded when modelling AD is the motion of the vessel wall, which has been shown to significantly impact simulation results. Fluid-structure interaction (FSI) methods are difficult to implement and are subject to assumptions regarding the mechanical properties of the vessel wall, which cannot be retrieved non-invasively...
May 11, 2018: Medical Engineering & Physics
https://www.readbyqxmd.com/read/29753424/-assessment-of-medical-management-of-heart-failure-at-national-hospital-blaise-compaore
#7
Y Kambiré, L Konaté, I Diallo, G R C Millogo, K J Kologo, J B Tougouma, A K Samadoulougou, P Zabsonré
AIM: The aim of this study was to assess the quality of medical management of heart failure at the National Hospital Blaise Compaoré according to the international guidelines. PATIENTS AND METHODS: A retrospective study was performed including consecutive patients admitted for heart failure documented sonographically from October 2012 to March 2015 in the Medicine and Medical Specialties Department of National Hospital Blaise Compaore with a minimum follow-up of six weeks...
May 9, 2018: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/29745618/medical-management-of-stable-peripheral-artery-disease-pad-and-the-compass-trial-are-we-improving-medical-care-perspectives-from-a-vascular-standpoint
#8
Eduardo Ramacciotti, Valter Castelli, Jeanine Walenga, Jawed Fareed
No abstract text is available yet for this article.
May 9, 2018: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/29734688/skin-protective-nutraceuticals-the-current-evidence-in-brief
#9
Oroma Nwanodi
Nutraceuticals are important for healthy skin maintenance. Probiotics, phenolics, and vitamins are just a few of the nutraceuticals meant to potentially prevent and assist medical management of dermatologic conditions. Among these, probiotics, vitamin E, and green tea catechins may offer the broadest array of skin protective mechanisms with probiotics having the greatest clinical range. Probiotics’ amelioration of atopic dermatitis and opportunistic infections of skin burns has been targeted in recent research efforts...
May 4, 2018: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/29727608/medical-management-of-functional-impairment-in-peripheral-artery-disease-a-review
#10
REVIEW
Mary M McDermott
Lower extremity peripheral artery disease (PAD) now affects 200 million people worldwide and is a major cause of disability. Cilostazol is the only Federal Drug Administration approved medication for PAD-related ischemic symptoms that is recommended by clinical practice guidelines. Supervised treadmill exercise significantly improves treadmill walking performance in PAD. Recent evidence shows that home-based exercise interventions that include occasional medical center visits and incorporate behavioral change techniques also significantly improve walking endurance in PAD...
March 28, 2018: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29724210/drug-use-in-the-management-of-uncomplicated-malaria-in-public-health-facilities-in-the-democratic-republic-of-the-congo
#11
Nsengi Y Ntamabyaliro, Christian Burri, Didier B Nzolo, Aline B Engo, Yves N Lula, Samuel M Mampunza, Célestin N Nsibu, Gauthier K Mesia, Jean-Marie N Kayembe, Joris L Likwela, Leon M Kintaudi, Gaston L Tona
BACKGROUND: Malaria the first causes of death from parasitic infection worldwide. Interventions to reduce the burden of malaria have produced a tremendous drop in malaria morbidity and mortality. However, progress is slower in DRC, which shares with Nigeria 39% of deaths related to malaria globally. Inappropriate use of drugs may be one of the factors of this below-average performance. The aim of this study was to describe the use of drugs in the management of uncomplicated malaria in public health facilities in DRC...
May 3, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29707206/recent-advances-in-biologic-therapy-of-asthma-and-the-role-in-therapy-of-chronic-rhinosinusitis
#12
REVIEW
Rohit Divekar, Devyani Lal
Great strides have been made in the last five years in understanding the pathology of chronic rhinosinusitis (CRS). CRS is now accepted to be the end-stage manifestation of inflammation resultant from various pathogenetic mechanisms. This has resulted in increasing recognition of distinct CRS endotypes. Such endotypes encompass a cluster of patients with similar pathogenic mechanisms that may have common therapeutic targets and responsiveness to interventions. The elucidation of mechanisms leading to the development of chronic upper (sino-nasal) airway inflammation has to some extent paralleled investigations of aberrant pathways operant in asthma...
2018: F1000Research
https://www.readbyqxmd.com/read/29696080/therapeutic-effects-of-serum-extracellular-vesicles-in-liver-fibrosis
#13
Li Chen, Ruju Chen, Sherri Kemper, Min Cong, Hong You, David R Brigstock
The lack of approved therapies for hepatic fibrosis seriously limits medical management of patients with chronic liver disease. Since extracellular vesicles (EVs) function as conduits for intercellular molecular transfer, we investigated if EVs from healthy individuals have anti-fibrotic properties. Hepatic fibrogenesis or fibrosis in carbon tetrachloride (CCl4 )- or thioacetic acid-induced liver injury models in male or female mice were suppressed by serum EVs from normal mice (EVN) but not from fibrotic mice (EVF)...
2018: Journal of Extracellular Vesicles
https://www.readbyqxmd.com/read/29695911/amantadine-extended-release-capsules-for-levodopa-induced-dyskinesia-in-patients-with-parkinson-s-disease
#14
REVIEW
Vibhash D Sharma, Kelly E Lyons, Rajesh Pahwa
Levodopa-induced dyskinesia (LID) is a common motor complication in patients with Parkinson's disease on chronic levodopa therapy. The management of LID is important as dyskinesia can be disabling and impair quality of life. Currently, there are limited treatment options for the medical management of LID. Amantadine extended-release capsules (Gocovri™) is the first medication that received US Food and Drug Administration approval for the treatment of LID. The following is a review of the pharmacodynamics, efficacy and safety profile, and current state of treatment of amantadine for LID...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29686959/two-simulation-cases-to-prepare-for-a-public-festival-pediatric-methylenedioxymethamphetamine-mdma-ingestion-and-alcohol-toxicity
#15
Emily Z Roben, Karen Mangold, Christina Cochran
Introduction Emergency departments (EDs) see a surge of intoxicated patients during large public summer events. These patients can be distracting and complicated for ED staff to care for. Methods We developed two cases to prepare emergency department staff for an anticipated surge of patients related to a large music festival that occurs proximal to our pediatric hospital. We developed and performed cases of simulated patients with alcohol intoxication and methylenedioxymethamphetamine (MDMA) ingestion to review medical management of these patients, as well as to review many of the social aspects of the cases...
February 21, 2018: Curēus
https://www.readbyqxmd.com/read/29685658/novel-founder-intronic-variant-in-slc39a14-in-two-families-causing-manganism-and-potential-treatment-strategies
#16
Lance H Rodan, Marissa Hauptman, Alissa M D'Gama, Anita E Qualls, Siqi Cao, Karin Tuschl, Fatma Al-Jasmi, Jozef Hertecant, Susan J Hayflick, Marianne Wessling-Resnick, Edward T Yang, Gerard T Berry, Andrea Gropman, Alan D Woolf, Pankaj B Agrawal
Congenital disorders of manganese metabolism are rare occurrences in children, and medical management of these disorders is complex and challenging. Homozygous exonic mutations in the manganese transporter SLC39A14 have recently been associated with a pediatric-onset neurodegenerative disorder characterized by brain manganese accumulation and clinical signs of manganese neurotoxicity, including parkinsonism-dystonia. We performed whole exome sequencing on DNA samples from two unrelated female children from the United Arab Emirates with progressive movement disorder and brain mineralization, identified a novel homozygous intronic mutation in SLC39A14 in both children, and demonstrated that the mutation leads to aberrant splicing...
April 6, 2018: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/29685620/medical-management-of-a-prolactinoma-in-a-15-year-old-girl
#17
Morgan S Bowling, Alejandro Zamudio, Fatema Jaffery
No abstract text is available yet for this article.
April 20, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29674485/management-of-endocrine-disease-diagnosis-and-management-of-primary-aldosteronism-the-endocrine-society-guideline-2016-revisited
#18
Tracy Ann Williams, Martin Reincke
The syndrome of primary aldosteronism (PA) is characterized by hypertension with excessive, autonomous aldosterone production and is usually caused by either a unilateral aldosterone-producing adenoma (APA) or bilateral adrenal hyperplasia (BAH). The diagnostic workup of PA is a sequence of three phases comprising screening tests, confirmatory tests and the differentiation of unilateral from bilateral forms. The latter step is necessary to determine the optimal treatment approach of unilateral laparoscopic adrenalectomy (for patients with unilateral PA) or medical treatment with a mineralocorticoid receptor antagonist (for patients with bilateral PA)...
April 19, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29666199/does-magnesium-sulfate-have-a-role-in-the-management-of-severe-traumatic-brain-injury-in-civilian-and-military-populations-a-systematic-review-and-meta-analysis
#19
REVIEW
Marc W H Lyons, W J Blackshaw
INTRODUCTION: Traumatic brain injury (TBI) is a significant cause of combat morbidity. Currently, the medical management of TBI is limited to supportive critical care. Magnesium sulfate has been studied as a potentially beneficial therapeutic agent. METHODS: A systematic review and meta-analysis was undertaken, examining the role of magnesium in the management of severe TBI in adults. The primary outcome of the study was all-cause mortality, with secondary outcomes of Glasgow Outcome Score (GOS) and GCS...
April 17, 2018: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/29652872/medical-management-of-transgender-children-and-adolescents
#20
María Fernanda Castilla-Peón
Transgender or gender nonconforming (GN) persons identify themselves with a gender which is different from that correspondent to their birth sex. The demand for health services by families with transgender children or adolescents tends to increase. The prevalence of GN in children is unknown; however, it has been estimated to be > 1% in adolescents. Transgender persons are at increased risk of depression, suicide, illicit drug abuse, human immunodeficiency virus infection, and non-accidental injury. The most accepted model for the care of transgender persons assumes that these adverse outcomes are the consequence of social margination rather than the GI condition itself...
2018: Boletín Médico del Hospital Infantil de México
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