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https://www.readbyqxmd.com/read/28923219/randomized-clinical-trials-in-gastrointestinal-stromal-tumors
#1
REVIEW
Yang Liu, Margaret von Mehren
This review explores the current standard of care for the surgical management of gastrointestinal stromal tumors, highlights important studies in the medical management of gastrointestinal stromal tumors, and provides guidance in how these studies changed the standard of care in clinical practice.
October 2017: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/28916211/diaphragmatic-fenestration-for-refractory-chylothorax-after-congenital-cardiac-surgery-in-infants
#2
T K Susheel Kumar, Kaitlin Balduf, Umar Boston, Christopher Knott-Craig
OBJECTIVE: Medically refractory chylous pleural effusion after congenital heart surgery is associated with significant morbidity and mortality, especially in infants. We reviewed our experience with diaphragmatic fenestration procedure in this group of patients. METHODS: A retrospective chart review of all patients who had diaphragmatic fenestrations for chylous effusion at our institution over a 2-year period was performed. RESULTS: A total of 9 diaphragmatic fenestration procedures were performed in 8 patients who had failed medical management of chylous pleural effusions...
August 17, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28916114/-scleritis-and-episcleritis
#3
REVIEW
E Héron, T Bourcier
Episcleritis is generally a benign disease with a self-limited course, while scleritis is a severe ocular condition due to a risk of impaired vision in one-fifth of patients and its association with systemic diseases in one third of them. Infectious scleritis, representing 8 % of the etiologies, is mainly of herpetic origin (varicella zoster and herpes simplex viruses). A systemic autoimmune disease is observed in roughly 30 % of scleritis patients: inflammatory rheumatisms (15 %), firstly rheumatoid polyarthritis, systemic vasculitides (8 %), mainly granulomatosis with polyangiitis (Wegener's) and polychondritis, and less often inflammatory bowel disease and systemic lupus erythematosus...
September 12, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28915135/otolaryngologic-management-of-down-syndrome-patients-what-is-new
#4
Ethan C Bassett, Mary F Musso
PURPOSE OF REVIEW: The management of children with Down syndrome as it pertains to the otolaryngologist continues to evolve. Obstructive sleep apnea (OSA) has dominated the recent literature, but other topics including hearing loss, swallowing, and perioperative considerations are also reported. RECENT FINDINGS: The prevalence of OSA in children with Down syndrome ranges from 57 to 73% in certain cohorts, and, whereas adentonsillectomy can decrease Apnea-Hypopnea Index, up to 80% may have persistent OSA...
September 14, 2017: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/28904582/giant-intracerebral-tuberculoma-with-complete-disappearance-on-antitubercular-therapy-alone-in-a-pediatric-case-a-case-illustration-with-review-of-management-strategy
#5
Guru Dutta Satyarthee
The Central nervous system can be affected in extrapulmonary tuberculosis. The intracranial tuberculoma occurrence is a rare entity occurrence; most often occur in the form of discrete small multiple lesions. Rarely a large sized tuberculoma is observed with mass effects and usually managed surgically to provide rapid relief of mass effect, histopathological confirmation of diagnosis, reduction of pathological mass thereby increasing efficacy of medical therapy. Author reports an extremely rare case of giant tuberculoma occurring in a pediatric patient, which was managed with antituberculous medication along with cerebral decongestant...
April 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/28904008/mechanisms-in-endocrinology-clinical-and-pharmacogenetic-aspects-of-the-growth-hormone-receptor-polymorphism
#6
Cesar Luiz Boguszewski, Edna Jesus Litenski Barbosa, Per-Arne Svensson, Gudmundur Johannsson, Camilla A M Glad
Pharmacogenetics aims to maximize the beneficial effects of a medical therapy by identifying genetic finger prints from responders and non-responders and, thereby, improving safety and efficacy profile of the drug. Most subjects who are deficient in growth hormone (GHD) are candidates for recombinant human GH (rhGH) therapy. To date, it is well established that even after adjustments for several clinical variables, such as age, gender, body composition and the age at onset of the GHD, response to rhGH treatment is highly variable among individuals, part of which is believed to be due to genetic factors within the GH system...
September 13, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28895508/esvm-guidelines-the-diagnosis-and-management-of-raynaud-s-phenomenon
#7
Jill Belch, Anita Carlizza, Patrick H Carpentier, Joel Constans, Faisel Khan, Jean-Claude Wautrecht, Adriana Visona, Christian Heiss, Marianne Brodeman, Zsolt Pécsvárady, Karel Roztocil, Mary-Paula Colgan, Dragan Vasic, Anders Gottsäter, Beatrice Amann-Vesti, Ali Chraim, Pavel Poredoš, Dan-Mircea Olinic, Juraj Madaric, Sigrid Nikol, Ariane L Herrick, Muriel Sprynger, Peter Klein-Weigel, Franz Hafner, Daniel Staub, Zan Zeman
Regarding the clinical diagnosis of Raynaud's phenomenon and its associated conditions, investigations and treatment are substantial, and yet no international consensus has been published regarding the medical management of patients presenting with this condition. Most knowledge on this topic derives from epidemiological surveys and observational studies; few randomized studies are available, almost all relating to drug treatment, and thus these guidelines were developed as an expert consensus document to aid in the diagnosis and management of Raynaud's phenomenon...
September 12, 2017: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/28895017/total-pancreatectomy-with-islet-autotransplantation-for-acute-recurrent-and-chronic-pancreatitis
#8
REVIEW
Varvara A Kirchner, Ty B Dunn, Gregory J Beilman, Srinath Chinnakotla, Timothy L Pruett, Joshua J Wilhelm, Sarah J Schwarzenberg, Martin L Freeman, Melena D Bellin
PURPOSE OF REVIEW: The first total pancreatectomy and islet autotransplantation (TP-IAT) was performed for chronic pancreatitis in 1977 with the goal to ameliorate the pain and simultaneously preserve islet function. We reviewed the recent medical literature regarding indications, patient suitability, current outcomes, and challenges in TP-IAT. RECENT FINDINGS: Current indications for TP-IAT include intractable pain secondary to chronic pancreatitis (CP) or acute recurrent pancreatitis (ARP) with failed medical and endoscopic/surgical management...
September 11, 2017: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/28889455/management-of-primary-aldosteronism-in-patients-with-adrenal-hemorrhage-following-adrenal-vein-sampling-a-brief-review-with-illustrative-cases
#9
REVIEW
Fady Hannah-Shmouni, Andrew Demidowich, Beatriz Rizkallah Alves, Gabriela Dockhorn Paluch, Dionysiou Margarita, Charalampos Lysikatos, Elena Belyavskaya, Richard Chang, Constantine A Stratakis
The authors describe the clinical investigation of two cases of primary aldosteronism with adrenal hemorrhage (AH) following adrenal vein sampling. A literature review was conducted regarding the medical management of primary aldosteronism in patients with AH following adrenal vein sampling. Guidelines on the management of primary aldosteronism with AH following adrenal vein sampling are lacking. The two patients were followed with serial imaging to document resolution of AH and treated medically with excellent blood pressure response...
September 9, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28887078/management-of-residual-subdural-hematoma-after-burr-hole-evacuation-the-role-of-fluid-therapy-and-review-of-the-literature
#10
Nicola Montano, Vito Stifano, Benjamin Skrap, Edoardo Mazzucchi
A vast amount of literature has been published investigating the factors associated to the recurrence of a chronic subdural hematoma (SDH). However, little exists in the literature about the best medical management of the residual SDH in order to prevent the recurrence. Moreover only few studies quantitatively assess clinical and radiological outcomes of residual post-operative SDH. In this study, to our knowledge, we report the first series of chronic SDH with a quantitative outcomes analysis of the effects of fluid therapy on residual post-operative SDH...
September 5, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28885561/acute-and-late-toxicities-of-concurrent-chemoradiotherapy-for-locally-advanced-non-small-cell-lung-cancer
#11
REVIEW
Vivek Verma, Charles B 2nd Simone, Maria Werner-Wasik
For patients with unresectable locally-advanced non-small cell lung cancer (LA-NSCLC), concurrent chemoradiotherapy improves overall survival as compared to sequential chemotherapy and radiation therapy, but is associated with higher rates of toxicities. Acute, clinically significant esophagitis or pneumonitis can occur in one in five patients. The risks of esophagitis and pneumonitis can impact the decision to deliver concurrent therapy and limit the total dose of radiation therapy that is delivered. Hematologic toxicities and emesis are common toxicities from systemic therapies for LA-NSCLC and can result in delaying chemotherapy dosing or chemotherapy dose reductions...
September 8, 2017: Cancers
https://www.readbyqxmd.com/read/28883919/a-case-of-klinefelter-syndrome-with-hypersexual-desire
#12
Kingsley Okolie, Sumathy Perampalam, Anthony Barker, Christopher J Nolan
Klinefelter syndrome (KS) is a chromosomal disorder affecting males, with the typical karyotype of 47,XXY due to a supernumerary X chromosome, which causes progressive testicular failure resulting in androgen deficiency and infertility. Despite it being the most common sex chromosomal disorder, its diagnosis is easily missed. In addition to its classical clinical features of tall stature, gynaecomastia, small testes, and symptoms and signs of hypogonadism including infertility, KS is also often associated with neurocognitive, behavioural and psychiatric disorders...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28883749/student-selected-component-in-the-medical-curriculum-investigations-and-psychiatric-referral-for-paracetamol-overdose-in-an-accident-and-emergency-department
#13
James G Cowman, Manuel Bakheet
BACKGROUND: A student-selected component (SSC) of the medical curriculum requires the student to be self-directed in locating and undertaking a placement in a clinical specialty of their choosing and completing a project. The clinical area for experience was an accident and emergency department, and our topic was a focused audit on the investigations and referral for paracetamol overdose. The purpose of this paper is twofold: to reflect on the education value to medical students of an SSC in a medical curriculum, and to highlight learning and understanding through completion of an audit...
2017: Advances in Medical Education and Practice
https://www.readbyqxmd.com/read/28877714/successful-medical-management-of-a-case-of-austrian-syndrome-an-uncommon-entity-in-the-modern-antibiotic-era-a-case-report
#14
Muhammad Abdur Rahim, Shahana Zaman, Hasna Fahmima Haque, Samira Rahat Afroze, Khwaja Nazim Uddin
BACKGROUND: Austrian syndrome-the combination of meningitis, pneumonia and infective endocarditis due to Streptococcus pneumoniae infection, is a rare entity. In literature only a few hundreds of cases are reported but surprisingly we did not find any report on Austrian syndrome in or from Bangladesh. CASE PRESENTATION: We report the case history of a middle aged Bangladeshi diabetic man, who had fever, cough, shortness of breath and altered mentation. He had tachycardia, bi-basal lung crepitations, new cardiac murmurs and meningism...
September 6, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28868599/diving-with-pre-existing-medical-conditions
#15
John Lippmann, David McD Taylor, Christopher Stevenson, Jo Williams, Simon J Mitchell
INTRODUCTION: This is the second report based on a survey of Divers Alert Network Asia-Pacific (DAN AP) members who dive with cardiovascular and respiratory conditions and diabetes. It examines the medical management of the divers' conditions, any diving modifications used to mitigate the risk and outcomes. METHODOLOGY: An online cross-sectional survey was sent to 833 divers who had declared a targeted medical condition when applying for DAN AP membership between July 2009 and August 2013...
September 2017: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
https://www.readbyqxmd.com/read/28868511/optimization-of-urinary-dipstick-ph-are-multiple-dipstick-ph-readings-reliably-comparable-to-commercial-24-hour-urinary-ph
#16
Joel E Abbott, Daniel L Miller, William Shi, David Wenzler, Fuad F Elkhoury, Nishant D Patel, Roger L Sur
PURPOSE: Accurate measurement of pH is necessary to guide medical management of nephrolithiasis. Urinary dipsticks offer a convenient method to measure pH, but prior studies have only assessed the accuracy of a single, spot dipstick. Given the known diurnal variation in pH, a single dipstick pH is unlikely to reflect the average daily urinary pH. Our goal was to determine whether multiple dipstick pH readings would be reliably comparable to pH from a 24-hour urine analysis. MATERIALS AND METHODS: Kidney stone patients undergoing a 24-hour urine collection were enrolled and took images of dipsticks from their first 3 voids concurrently with the 24-hour collection...
September 2017: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/28861506/the-clinical-significance-of-endocannabinoids-in-endometriosis-pain-management
#17
REVIEW
Jerome Bouaziz, Alexandra Bar On, Daniel S Seidman, David Soriano
Introduction: Patients with endometriosis often suffer from diffuse and poorly localized severe pain. The current pain management strategies include medical and hormonal therapy, as well as surgery. Medical management of pain is often insufficient and is associated with high rate of recurrence. Better pain management is therefore of urgent need. Methods: Among the various candidates, the endocannabinoid system (ECS) has recently emerged as a relevant pharmacological target for the management of endometriosis-related pain...
2017: Cannabis and Cannabinoid Research
https://www.readbyqxmd.com/read/28861040/a-case-of-acoustic-shock-with-post-trauma-trigeminal-autonomic-activation
#18
Alain Londero, Nicolas Charpentier, Damien Ponsot, Philippe Fournier, Laurent Pezard, Arnaud J Noreña
This study reports the case of an acoustic shock injury (ASI), which did not result in a significant hearing loss, but was followed by manifold chronic symptoms both within (tinnitus, otalgia, tingling in the ear, tension in the ear, and red tympanum) and outside the ears (blocked nose, pain in the neck/temporal region). We suggest that these symptoms may result from a loop involving injury to middle ear muscles, peripheral inflammatory processes, activation and sensitization of the trigeminal nerve, the autonomic nervous system, and central feedbacks...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28855457/basic-medical-management-of-sleep-disordered-breathing-in-elderly
#19
(no author information available yet)
No abstract text is available yet for this article.
2017: Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
https://www.readbyqxmd.com/read/28830265/are-changes-necessary-in-the-medical-management-of-a-patient-with-snakebite-regarding-the-incidence-of-hypersensitivity-reaction-to-antivenom-polyvalent-immune-fab
#20
Claire Mailhol, Nicolas Delcourt, Pôl-André Apoil, Alain Didier, Nicolas Franchitto
No abstract text is available yet for this article.
August 23, 2017: Clinical Toxicology
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