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JOURNAL ARTICLE
Erkan Topkan, Ugur Selek, Berrin Pehlivan, Ahmet Kucuk, Duriye Ozturk, Beyza Sirin Ozdemir, Ali Ayberk Besen, Huseyin Mertsoylu
BACKGROUND: We sought to determine the prognostic value of the newly developed Global Immune-Nutrition-Inflammation Index (GINI) in patients with stage IIIC non-small cell lung cancer (NSCLC) who underwent definitive concurrent chemoradiotherapy (CCRT). METHODS: This study was conducted on a cohort of 802 newly diagnosed stage IIIC NSCLC patients who underwent CCRT. The novel GINI created first here was defined as follows: GINI = [C-reactive protein × Platelets × Monocytes × Neutrophils] ÷ [Albumin × Lymphocytes]...
September 11, 2023: Cancers
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JOURNAL ARTICLE
Erdoğan Öz, Mehmet Emin Parlak, Yaşar Kapıcı, Umut Balatacı, Osman Küçükkelepçe, Fatma Kurt
This study aimed to examine potential disparities in hematologic inflammation parameters between children diagnosed with attention deficit hyperactivity disorder (ADHD) and their healthy counterparts and to determine whether atomoxetine treatment induced any alterations in inflammation indicators. This case-control study involved 43 children aged 6-13 years, 22 diagnosed with ADHD for the first time, and 21 healthy children. In all children, complete blood count and albumin, C-reactive protein (CRP), thyroid stimulating hormone (TSH), free thyroxine (free T4), folate, vitamin B12, aspartate aminotransferase (AST), alanine transaminase (ALT), creatinine and urea values were performed...
September 27, 2023: Scientific Reports
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JOURNAL ARTICLE
Enrico Pompili, Maurizio Baldassarre, Giorgio Bedogni, Giacomo Zaccherini, Giulia Iannone, Clara De Venuto, Dario Pratelli, Francesco Palmese, Marco Domenicali, Paolo Caraceni
BACKGROUND AND AIMS: The PREDICT study recently showed that acutely decompensated (AD) patients with cirrhosis can present three different clinical phenotypes in the 90 days after admission: (1) pre-ACLF, developing acute-on-chronic liver failure (ACLF); (2) unstable decompensated cirrhosis (UDC), being re-admitted for AD without ACLF and (3) stable decompensated cirrhosis (SDC), not presenting readmission or ACLF. This study aimed to externally validate the existence of these three distinct trajectories and to identify predictors for the occurrence of each trajectory...
September 18, 2023: Liver International: Official Journal of the International Association for the Study of the Liver
#24
JOURNAL ARTICLE
Mohamed Mohamed Soliman, Ahmed M Elshehawei, Saed Althobaiti, Samy M Sayed
Current study examined the boosting impacts of Withania somnifera leaf extract from Taif area (high-altitude area) against hepatic and renal toxicity induced by diclofenac in experimental rats. Withania is highly grown on Taif area as environmental herb with multiple functions. Diclofenac is non-steroidal medication used for treatment of pain but over dose has severe side effects. Thirty-two adult Wistar rats of male type were subdivided into 4 groups. The control rats (group 1) received saline. Second group received diclofenac (50 mg/kg BW intraperitoneally) at days 4 and 5...
August 2023: Toxicology Research
#25
JOURNAL ARTICLE
Christina Gress, Jens Vogel-Claussen, Philipp Badorrek, Meike Müller, Kathrin Hohl, Marilisa Konietzke, Tobias Litzenburger, Wolfgang Seibold, Abhya Gupta, Jens M Hohlfeld
BACKGROUND: Bradykinin 1 receptor (B1R) signalling pathways may be involved in the inflammatory pathophysiology of chronic obstructive pulmonary disease (COPD). B1R signalling is induced by inflammatory stimuli or tissue injury and leads to activation and increased migration of pro-inflammatory cells. Lipopolysaccharide (LPS) lung challenge in man is an experimental method of exploring inflammation in the lung whereby interference in these pathways can help to assess pharmacologic interventions in COPD...
August 8, 2023: Pulmonary Pharmacology & Therapeutics
#26
JOURNAL ARTICLE
Amrendra Kumar, Lavanya Gurram, Prashant Nayak, Gargee Mulye, Pushpa Naga Ch, Supriya Chopra, Reena Engineer, Shyam Kishore Shrivastava, Sudeep Gupta, Jaya Ghosh, Seema Gulia, Jai Prakash Agarwal, Umesh Mahantshetty
BACKGROUND: Variations in the levels of systemic inflammatory biomarker levels have been linked with outcomes in various malignancies including cervical cancer. In this study, we investigate prognostic implications of pre-treatment haematological factors/indices in locally advanced cervical cancers treated with radical radio (chemo) therapy. MATERIALS AND METHODS: Electronic medical records of 1051 cervical cancer patients of FIGO stage IB2 - IVA, treated in various prospective trials at our institute between 2003 and 2017 were reviewed...
July 26, 2023: International Journal of Radiation Oncology, Biology, Physics
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JOURNAL ARTICLE
Chia-Sui Weng, Wan-Chun Huang, Chih-Long Chang, Ya-Ting Jan, Tze-Chien Chen, Jie Lee
BACKGROUND: Malignant ascites is prevalent in advanced-stage ovarian cancer and may facilitate identification of the drivers of muscle loss. This study aimed to evaluate the association of ascites with changes in systemic inflammation and muscle after treatment of advanced-stage ovarian cancer. METHODS: We evaluated 307 patients with advanced-stage (III/IVA) ovarian cancer who underwent primary debulking surgery and adjuvant platinum-based chemotherapy between 2010 and 2019...
July 28, 2023: Journal of Cachexia, Sarcopenia and Muscle
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JOURNAL ARTICLE
Chen Chen, Zehua Wang, Yanru Qin
PURPOSE: This study aims to construct a novel hematological inflammation-nutrition score (HINS) and investigate its prognostic value in patients with advanced gastric cancer (AGC). We investigated the risk stratification performance of HINS and developed a HINS-based nomogram model to predict overall survival by combining traditional predictors. PATIENTS AND METHODS: We conducted a retrospective study on 812 AGC patients who received first-line platinum- or fluoropyrimidine-containing chemotherapy at The First Affiliated Hospital of Zhengzhou University Hospital between 2014 and 2019...
2023: Journal of Inflammation Research
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JOURNAL ARTICLE
Yang Zhao, Jun Liu, Zhengping Xiong, Shanzhi Gu, Xibin Xia
OBJECTIVE: This retrospective study aimed to investigate whether pre-treatment inflammatory biomarkers, including the prognostic nutritional index (PNI), monocyte-lymphocyte ratio (MLR), systemic immune inflammation index (SII), and platelet-lymphocyte ratio (PLR), could predict treatment response and prognosis in patients with hepatocellular carcinoma (HCC) receiving hepatic arterial infusion chemotherapy (HAIC) with the oxaliplatin, leucovorin, and fluorouracil (FOLFOX) regimen. METHODS: Based on the cut-off values identified using the receiver-operating characteristic (ROC) curve, 124 patients with HCC who received HAIC with the FOLFOX regimen were divided into low- and high-score MLR, PLR, PNI, and SII groups...
2023: Journal of Hepatocellular Carcinoma
#30
JOURNAL ARTICLE
Wei Teng, Tai-An Cheng, Po-Ting Lin, Chen-Chun Lin, Chun-Yen Lin, Shi-Ming Lin
Regorafenib improved prognosis for unresectable hepatocellular carcinoma (uHCC) after sorafenib treatment failure. We aimed to investigate prognostic value of combining systemic inflammatory markers with liver function evaluation in patients receiving sorafenib-regorafenib sequential therapy. A total of 122 uHCC patients who received sorafenib-regorafenib sequential therapy were retrospectively enrolled for analysis. The pre-treatment preserving liver function and six inflammatory indexes were collected. The Cox regression model was used to identify independent predictors of progression-free survival (PFS) and overall survival (OS)...
2023: American Journal of Cancer Research
#31
JOURNAL ARTICLE
Eileen Uribe-Querol, Laura Romero-Romero, Tzipe Govezensky, Carlos Rosales
INTRODUCTION: In veterinary medicine, cancer is the leading cause of death in companion animals, and mammary gland tumors represent the most common neoplasm in female dogs. Several epidemiological risk factors, such as age, breed, hormones, diet, and obesity have been reported to be relevant for canine mammary tumors. Nowadays, the gold standard for diagnosis of canine mammary tumors is the pathological examination of the suspected tissue. However, tumor grade can only be assessed after surgical removal or biopsy of the altered tissue...
2023: Frontiers in Veterinary Science
#32
JOURNAL ARTICLE
Itaru Hashimoto, Kazuki Kano, Shizune Onuma, Hideaki Suematsu, Shinsuke Nagasawa, Kyohei Kanematsu, Kyoko Furusawa, Tomomi Hamaguchi, Mamoru Watanabe, Kei Hayashi, Mitsuhiro Furuta, Yasuhiro Inokuchi, Nozomu Machida, Toru Aoyama, Takanobu Yamada, Yasushi Rino, Takashi Ogata, Takashi Oshima
Trifluridine/tipiracil (FTD/TPI) is an oral anticancer agent used as a third- or later-line treatment for patients with metastatic gastric cancer/gastroesophageal junction cancer (mGC/GEJC). The C-reactive protein-to-serum albumin ratio (CAR) is an inflammation-based prognostic marker in gastric cancer. This retrospective study evaluated CAR's clinical significance as a prognostic factor in 64 patients with mGC/GEJC administered FTD/TPI as a third- or later-line therapy. Patients were categorized into high- and low-CAR groups based on pre-treatment blood data...
May 31, 2023: Journal of Personalized Medicine
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RANDOMIZED CONTROLLED TRIAL
Banwari Agarwal, Rafael Bañares Cañizares, Faouzi Saliba, Maria Pilar Ballester, Dana Rodica Tomescu, Daniel Martin, Vanessa Stadlbauer, Gavin Wright, Mohammed Sheikh, Carrie Morgan, Carlos Alzola, Phillip Lavin, Daniel Green, Rahul Kumar, Sophie Caroline Sacleux, Gernot Schilcher, Sebastian Koball, Andrada Tudor, Jaak Minten, Gema Domenech, Juan Jose Aragones, Karl Oettl, Margret Paar, Katja Waterstradt, Stefanie M Bode-Boger, Luis Ibáñez-Samaniego, Amir Gander, Carolina Ramos, Alexandru Chivu, Jan Stange, Georg Lamprecht, Moises Sanchez, Rajeshwar P Mookerjee, Andrew Davenport, Nathan Davies, Marco Pavesi, Fausto Andreola, Agustin Albillos, Jeremy Cordingley, Hartmut Schmidt, Juan Antonio Carbonell-Asins, Vicente Arroyo, Javier Fernandez, Steffen Mitzner, Rajiv Jalan
BACKGROUND & AIMS: Acute-on-chronic liver failure (ACLF) is characterized by severe systemic inflammation, multi-organ failure and high mortality rates. Its treatment is an urgent unmet need. DIALIVE is a novel liver dialysis device that aims to exchange dysfunctional albumin and remove damage- and pathogen-associated molecular patterns. This first-in-man randomized-controlled trial was performed with the primary aim of assessing the safety of DIALIVE in patients with ACLF, with secondary aims of evaluating its clinical effects, device performance and effect on pathophysiologically relevant biomarkers...
July 2023: Journal of Hepatology
#34
Kejing Wang, Xing Jian, Ziwei Xu, Huafang Wang
[This corrects the article DOI: 10.3389/fimmu.2023.1128982.].
2023: Frontiers in Immunology
#35
JOURNAL ARTICLE
Buse Cagla Ari
OBJECTIVE: Acute ischemic stroke is a cause of long-term disability in developing countries. Intravenous tissue plasminogen activator (iv-tPA) is the most effective medical treatment shown to provide clinical improvement. Our aim in this study is to investigate the relationship between the clinical data of our patients treated with iv-tPA and the changes in serum inflammatory parameters; and to help increase the prevalence of treatment in secondary hospitals. METHODS: Forty-nine patients diagnosed as acute ischemic stroke and treated with iv-tPA at Siirt Research and Training Hospital between April 2019 and June 2020 were included in this study...
2023: Northern Clinics of Istanbul
#36
JOURNAL ARTICLE
Sarah A Altalhi, Serag Eldin I Elbehairi, Mohammad Y Alfaifi, Fawziah A Al-Salmi, Ali A Shati, Leena S Alqahtani, Eman Fayad, Reda F M Elshaarawy, Ali M Nasr
A newly synthesized nanoplatform of hyaluronic acid and chitosan nanoparticles (HA/CNPs) was applied to improve the therapeutic efficacy and protection of bone marrow mesenchymal stem cells (BM-MSCs) against cisplatin (CDDP)-induced nephrotoxicity in rats. CDDP administration causes significant increases in levels of serum creatinine (SCr), urea, and KIM-1 coupled with significant albumin level falls, as indicative of acute renal dysfunction. Moreover, the level of the antioxidant enzyme (GSH) was significantly decreased, while the levels of lipid peroxidation (MDA) and inflammatory (IL-6) and apoptotic (caspase-3) markers were significantly increased, indicating a decline in the kidney's antioxidant defense and increased inflammation...
May 5, 2023: International Journal of Pharmaceutics
#37
JOURNAL ARTICLE
Hira Moin, Riffat Shafi, Ayesha Ishtiaq, Afrose Liaquat, Sadaf Majeed, Nilofar Nasir Zaidi
Diabetes mellitus(DM) is associated with numerous complications, including nephropathy, which principally occur due to hyperglycemia-induced oxidative stress and inflammation. Humanin(HN), a novel peptide generated from mitochondria, has anti-oxidant and anti-inflammatory potential as observed in different disease models. However, role of HN in diabetic nephropathy (DN) has not yet been explored. This study aimed to evaluate biochemical and molecular aspects of the effects of HN analog, Humanin-glycine([S14G]-humanin) on streptozotocin (STZ)-induced rat model of DN...
April 27, 2023: Peptides
#38
JOURNAL ARTICLE
Alexandra Chovsepian, Olga Prokopchuk, Gabriela Petrova, Tefta Gjini, Hanna Kuzi, Simone Heisz, Klaus-Peter Janssen, Marc E Martignoni, Helmut Friess, Hans Hauner, Maria Rohm
OBJECTIVES: Cancer is considered an emerging diabetes complication, with higher incidence and worse prognosis in patients with diabetes. Cancer is frequently associated with cachexia, a systemic metabolic disease causing wasting. It is currently unclear how diabetes affects the development and progression of cachexia. METHODS: We investigated the interplay between diabetes and cancer cachexia retrospectively in a cohort of 345 patients with colorectal and pancreatic cancer...
April 22, 2023: Molecular Metabolism
#39
JOURNAL ARTICLE
Jun Pan, Jiao Li, Yuanjun Gao
OBJECTIVE: In recent years, a number of studies have suggested that inflammation-based biomarkers can be applied in the diagnostics and prognostic testing of disease. However, the association between these ratios and inflammatory bowel disease (IBD) remains unclear. We aimed to investigate the role of these inflammation-based ratios in patients with IBD. METHODS: Retrospective analysis of 362 patients with IBD and 100 healthy individuals from January 2016 and December 2021...
2023: Frontiers in Medicine
#40
JOURNAL ARTICLE
Silvia Helena de Carvalho Sales-Peres, Jack Houghton, Gabriela de Figueiredo Meira, Patrícia Garcia de Moura-Grec, Sergio Luis Aparecido Brienze, Belkais Abuuasha Karim, Guy Howard Carpenter
This study analyzed the salivary proteomics, adiponectin and albumin, related to weight loss and periodontitis in patients undergoing bariatric surgery. This study included fourteen patients with morbid obesity (body mass index, BMI > 40 kg/m2 ) who underwent bariatric surgery Roux-en-Y gastric bypass (RYGB) in System Health Public in Brazil. Data on demographic and anthropometric measures were extracted from medical records preoperatively and 6 and 12 months post-surgery. The variables assessed were: probing pocket depth (PPD), clinical attachment loss (CAL), bleeding on probing (BOP), and stimulated whole-mouth saliva...
March 24, 2023: International Journal of Environmental Research and Public Health
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