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pre albumin inflammation

Sara Marie Atkinson, Anneline Nansen
In this MiniReview, we summarise the body of knowledge on the delayed-type hypersensitivity arthritis (DTHA) model, a recently developed arthritis model with 100% incidence, low variation and synchronised onset in C57BL/6 (B6) mice, and compare it to other murine arthritis models. It is desirable to have robust arthritis models in B6 mice, as many transgene strains are bred on this background. However, several of the most widely used mouse model of arthritis cannot be induced in B6 mice without the drawback of lower incidence, reduced severity and higher variation, if at all...
August 24, 2016: Basic & Clinical Pharmacology & Toxicology
Matthew D Davidson, Kimberly R Ballinger, Salman R Khetani
Hyperglycemia in type 2 diabetes mellitus has been linked to non-alcoholic fatty liver disease, which can progress to inflammation, fibrosis/cirrhosis, and hepatocellular carcinoma. Understanding how chronic hyperglycemia affects primary human hepatocytes (PHHs) can facilitate the development of therapeutics for these diseases. Conversely, elucidating the effects of hypoglycemia on PHHs may provide insights into how the liver adapts to fasting, adverse diabetes drug reactions, and cancer. In contrast to declining PHH monocultures, micropatterned co-cultures (MPCCs) of PHHs and 3T3-J2 murine embryonic fibroblasts maintain insulin-sensitive glucose metabolism for several weeks...
2016: Scientific Reports
Dilek Aslan Kutsal, Seyhun Kürşat, Ayça İnci, Cevval Ulman, I OzanÜtük
There are two types of malnutrition in patients with chronic renal failure (CRF); type 1 and type 2. The aim of this study was to investigate the relationship between malnutrition and inflammation and also the relationship between malnutrition and volume status. Ninety-four pre-dialysis CRF patients were included in the study. Nutritional status of the patients was calculated using the subjective global assessment. Scores of 1-5 were given according to the severity of the symptoms and physical examination findings...
January 2016: Saudi Journal of Kidney Diseases and Transplantation
Marina C Oliveira, Luciana P Tavares, Juliana P Vago, Nathália V Batista, Celso M Queiroz-Junior, Angelica T Vieira, Gustavo B Menezes, Lirlândia P Sousa, Fons A J van de Loo, Mauro M Teixeira, Flávio A Amaral, Adaliene V M Ferreira
Metabolic alterations are associated with arthritis apart from obesity. However, it is still unclear which is the underlying process behind these metabolic changes. Here, we investigate the role of tumor necrosis factor (TNF) in this process in an acute model of antigen-induced arthritis (AIA). Immunized male BALB/c mice received an intra-articular injection of PBS (control) or methylated bovine serum albumin (mBSA) into their knees, and were also pre-treated with different drugs: Etanercept, an anti-TNF drug, DF2156A, a CXCR1/2 receptor antagonist, or a monoclonal antibody RB6-8C5 to deplete neutrophils...
2016: PloS One
Germaine D Agollah, Grace Wu, Ho-Lan Peng, Sunkuk Kwon
AIM: To investigate whether dermal lymphatic function and architecture are systemically altered in dextran sulfate sodium (DSS)-induced acute colitis. METHODS: Balb/c mice were administered 4% DSS in lieu of drinking water ad libitum for 7 d and monitored to assess disease activity including body weight, diarrhea severity, and fecal bleeding. Control mice received standard drinking water with no DSS. Changes in mesenteric lymphatics were assessed following oral administration of a fluorescently-labelled fatty acid analogue, while dermal lymphatic function and architecture was longitudinally characterized using dynamic near-infrared fluorescence (NIRF) imaging following intradermal injection of indocyanine green (ICG) at the base of the tail or to the dorsal aspect of the left paw prior to, 4, and 7 d after DSS administration...
December 7, 2015: World Journal of Gastroenterology: WJG
Koen Huysentruyt, Jean De Schepper, Jesse Vanbesien, Yvan Vandenplas
AIM: Albumin and pre-albumin are frequently used as nutritional markers in clinical practice. We examined whether serum albumin and pre-albumin were predicted by body mass index (BMI), hydration and/or inflammation in female adolescents with a recently diagnosed restrictive eating disorder (RED). METHODS: This was a retrospective study of female adolescents with RED from 2002 to 2011. Low albumin and pre-albumin levels were defined as <3.5 g/dL and <20 mg/dL, respectively...
April 2016: Acta Paediatrica
Seon-Young Han, Yean-Jung Choi, Min-Kyung Kang, Jung Han Yoon Park, Young-Hee Kang
A complicated interplay between resident mast cells and other recruited inflammatory cells contributes to the development and progression of allergic inflammation entailing the promotion of T helper 2 (Th2) cytokine responses. The current study examined whether resveratrol suppressed the production of inflammatory Th2 cytokines in cultured rat basophilic leukemia RBL-2H3 cells. Cells pre-treated with resveratrol nontoxic at 1–25 μM were sensitized with anti-dinitrophenyl (anti-DNP), and subsequently stimulated by dinitrophenyl-human serum albumin (DNP–HSA) antigen...
2015: American Journal of Chinese Medicine
Anthony J Bastin, Nathan Davies, Eric Lim, Greg J Quinlan, Mark J Griffiths
BACKGROUND AND OBJECTIVE: N-acetylcysteine has been used to treat a variety of lung diseases, where is it thought to have an antioxidant effect. In a randomized placebo-controlled double-blind study, the effect of N-acetylcysteine on systemic inflammation and oxidative damage was examined in patients undergoing lung resection, a human model of acute lung injury. METHODS: Eligible adults were randomized to receive preoperative infusion of N-acetylcysteine (240 mg/kg over 12 h) or placebo...
January 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
Vinayak Sudhir Jamdade, Nitin A Mundhe, Parveen Kumar, Venkatesh Tadla, Mangala Lahkar
Cisplatin induced nephrotoxicity is the chief obstacle in the use of cisplatin as chemotherapeutic agent. However, it remains as most widely employed anticancer agent to treat various solid tumours like head-neck, testicular, ovarian and mammary gland cancer. Raloxifene is claimed to be potent anti-inflammatory as well as anti-cancer agent. The present study was carried out to explore the effect of pre-treatment of raloxifene on cisplatin induced nephrotoxicity and its anti-tumour activity in 7, 12 dimethyl benz [a] anthracene induced mammary tumour in animal model...
January 2016: Pathology Oncology Research: POR
Huei-Fen Jheng, Pei-Jane Tsai, Yi-Lun Chuang, Yi-Ting Shen, Ting-An Tai, Wen-Chung Chen, Chuan-Kai Chou, Li-Chun Ho, Ming-Jer Tang, Kuei-Tai A Lai, Junne-Ming Sung, Yau-Sheng Tsai
Increased urinary albumin excretion is not simply an aftermath of glomerular injury, but is also involved in the progression of diabetic nephropathy (DN). Whereas Toll-like receptors (TLRs) are incriminated in the renal inflammation of DN, whether and how albumin is involved in the TLR-related renal inflammatory response remains to be clarified. Here, we showed that both TLR2 and TLR4, one of their putative endogenous ligands [heat shock protein 70 (HSP70)] and nuclear factor-κB promoter activity were markedly elevated in the kidneys of diabetic mice...
October 1, 2015: Disease Models & Mechanisms
Gamila S M El-Saeed, Fatina Fadel, Manal F Elshamaa, Rasha E E Galal, Eman A Elghoroury, Soha A Nasr, Eman H Thabet, Safaa M Abdelrahman
BACKGROUND: Advanced glycation end products (AGEs) have biological properties that may contribute to the mortality of children on hemodialysis (HD). This study examines the relationship of LMW fluorescence AGEs, oxidized LDL (ox-LDL), soluble receptor AGE (sRAGE) as markers of oxidative stress in children with end stage renal disease (ESRD) undergoing HD. METHOD: Thirty children with ESRD undergoing HD, and 30 healthy, age- and sex-matched children were included...
2015: Renal Failure
Åke Norberg, Olav Rooyackers, Ralf Segersvärd, Jan Wernerman
BACKGROUND: The drop in plasma albumin concentration following surgical trauma is well known, but the temporal pattern of the detailed mechanisms behind are less well described. The aim of this explorative study was to assess changes in albumin synthesis and transcapillary escape rate (TER) following major surgical trauma, at the time of peak elevations in two well-recognized markers of inflammation. METHODS: This was a clinical trial of radiolabeled human serum albumin for the study of TER and plasma volume...
2015: PloS One
Ezio Movilli, Corrado Camerini, Paola Gaggia, Roberto Zubani, Paolo Feller, Chiara Salviani, Annalisa Facchini, Giovanni Cancarini
BACKGROUND: Inflammation and increased erythropoiesis stimulating agents (ESA) requirement are frequently associated in patients on dialysis. On-line hemodiafiltration (ol-HDF), putting together high levels of diffusion, and convection could improve both conditions. However, it is still not known which depurative component plays a major role in determining this result. The aim of the study was to evaluate the role of convection and diffusion on long-term variations of serum β2 microglobulin (Δβ2M), high-sensitive C-reactive protein (ΔhsCRP) concentrations, and ESA requirement (ΔESA) in ol-HDF...
2015: American Journal of Nephrology
Xuan Hong, Baohong Cui, Meng Wang, Zhaoyang Yang, Li Wang, Qingyong Xu
Small cell lung cancer (SCLC) is an aggressive disease characterized by rapid growth and metastases. It has been recognized that the inflammation of the microenvironment plays a critical role in the development of malignancies. However, little is known about the role of multiple inflammatory and hematological markers in the prognosis of SCLC. The aim of this study was to determine the clinical significance of pre-treatment inflammation-based scores and characteristics as prognostic indicators for the survival of SCLC patients...
2015: Tohoku Journal of Experimental Medicine
Jana Zschüntzsch, Yaxin Zhang, Florian Klinker, Gregor Makosch, Lars Klinge, Dörthe Malzahn, Heinrich Brinkmeier, David Liebetanz, Jens Schmidt
Duchenne muscular dystrophy (DMD) is a severe hereditary myopathy. Standard treatment by glucocorticosteroids is limited because of numerous side effects. The aim of this study was to test immunomodulation by human immunoglobulin G (IgG) as treatment in the experimental mouse model (mdx) of DMD. 2 g/kg human IgG compared to human albumin was injected intraperitoneally in mdx mice at the age of 3 and 7 weeks. Advanced voluntary wheel running parameters were recorded continuously. At the age of 11 weeks, animals were killed so that blood, diaphragm, and lower limb muscles could be removed for quantitative PCR, histological analysis and ex vivo muscle contraction tests...
January 2016: Journal of Neurochemistry
Hirotaka Imamaki, Akira Ishii, Hideki Yokoi, Masato Kasahara, Takashige Kuwabara, Keita P Mori, Yukiko Kato, Takashi Kuwahara, Masugi Satoh, Kimihiko Nakatani, Yoshihiko Saito, Naohisa Tomosugi, Akira Sugawara, Kazuwa Nakao, Masashi Mukoyama, Motoko Yanagita, Kiyoshi Mori
BACKGROUND: Neutrophil gelatinase-associated lipocalin (NGAL or LCN2) is an iron-transporting factor which possesses various activities such as amelioration of kidney injury and host defense against pathogens. Its circulating concentrations are elevated in acute and chronic kidney diseases and show a positive correlation with poor renal outcome and mortality, but its clinical significance in maintenance hemodialysis (HD) patients remains elusive. METHODS: Serum NGAL levels were determined by enzyme-linked immunosorbent assay in out-patient, Japanese HD subjects...
2015: PloS One
Tina Sager, Michael Wolfarth, Michael Keane, Dale Porter, Vincent Castranova, Andrij Holian
Nanotechnology is emerging as one of the world's most promising new technologies. From a toxicology perspective, nanoparticles possess two features that promote their bioactivity. The first involves physical-chemical characteristics of the nanoparticle, which include the surface area of the nanoparticle. The second feature is the ability of the nanoparticle to traverse cell membranes. These two important nanoparticle characteristics are greatly influenced by placing nanoparticles in liquid medium prior to animal exposure...
2016: Nanotoxicology
Ya-Li Qiu, Hong Zhu, Shao-Gang Ma, Hong Liu, Qing Li, Chun-Mei Ji
OBJECTIVE: To investigate well-controlled congenital hypothyroidism on the markers associated with early kidney injury and oxidative DNA damage. METHODS: Twenty-three children with euthyroid congenital hypothyroidism aged 3-6 years and 19 age- and gender-matched controls were enrolled. Serum levels of albumin, C-reactive protein, cysteine C, globulin, pre-albumin, and total protein were detected. Urine levels of albumin, fibrin degradation products, IgG, β2-microglobulin, and 8-hydroxydeoxyguanosine (8-OHdG) were also measured...
July 2015: Journal of Pediatric Endocrinology & Metabolism: JPEM
Júlia Figueiredo Machado, Vanessa Oya, Cláudio Saddy Rodrigues Coy, André Moreno Morcillo, Silvana Dalge Severino, Chao Wu, Valdemiro Carlos Sgarbieri, Maria Marluce dos Santos Vilela
BACKGROUND: Crohn's disease (CD) is a chronic transmural inflammation of the gastrointestinal tract of unknown cause. Malnutrition associated with active CD has been reduced although obesity has increased. Dietary strategies such as those with high-protein have been proposed to reduce body fat. This study compares the effects of two supplements on the nutritional status of CD patients. MATERIALS AND METHODS: 68 CD patients were randomized in two groups: whey protein group (WP) and soy protein group (SP)...
2015: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Mark W Tenforde, Nikhil Gupte, David W Dowdy, David M Asmuth, Ashwin Balagopal, Richard B Pollard, Patcharaphan Sugandhavesa, Javier R Lama, Sandy Pillay, Sandra W Cardoso, Jyoti Pawar, Breno Santos, Cynthia Riviere, Noluthando Mwelase, Cecilia Kanyama, Johnstone Kumwenda, James G Hakim, Nagalingeswaran Kumarasamy, Robert Bollinger, Richard D Semba, Thomas B Campbell, Amita Gupta
OBJECTIVE: The association between pre-antiretroviral (ART) inflammation and immune activation and risk for incident tuberculosis (TB) after ART initiation among adults is uncertain. DESIGN: Nested case-control study (n = 332) within ACTG PEARLS trial of three ART regimens among 1571 HIV-infected, treatment-naïve adults in 9 countries. We compared cases (participants with incident TB diagnosed by 96 weeks) to a random sample of controls (participants who did not develop TB, stratified by country and treatment arm)...
2015: PloS One
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