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pre albumin inflammation

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https://www.readbyqxmd.com/read/28727654/growth-and-nutritional-biomarkers-of-preterm-infants-fed-a-new-powdered-human-milk-fortifier-a-randomized-trial
#1
Jacques Rigo, Jean-Michel Hascoët, Claude Billeaud, Jean-Charles Picaud, Fabio Mosca, Amandine Rubio, Elie Saliba, Michaël Radkë, Umberto Simeoni, Bernard Guillois, Virginie de Halleux, Jonathan Jaeger, Laurent Ameye, Nicholas P Hays, Johannes Spalinger
OBJECTIVES: Assess growth and nutritional biomarkers of preterm infants fed human milk (HM) supplemented with a new powdered HM fortifier (nHMF) or a control HM fortifier (cHMF). The nHMF provides similar energy content, 16% more protein (partially hydrolyzed whey), and higher micronutrient levels than the cHMF, along with medium-chain triglycerides and docosahexaenoic acid. METHODS: In this controlled, multicenter, double-blind study, a sample of preterm infants ≤32 weeks or ≤1500 g were randomized to receive nHMF (n = 77) or cHMF (n = 76) for a minimum of 21 days...
July 19, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28675572/association-between-frailty-and-carotid-intima-media-thickness-and-inflammatory-marker-in-an-elderly-population
#2
Chun-Chin Chang, Chien-Yi Hsu, Po-Hsun Huang, Li-Kuo Liu, Liang-Kung Chen, Jaw-Wen Chen, Shing-Jong Lin
AIM: Frailty is a highly prevalent geriatric syndrome, characterized by increased vulnerability to subsequent morbidity and mortality. The association between frailty and preclinical atherosclerosis remains uncertain. The aim of the present study was to clarify the relationship between frailty, preclinical atherosclerosis and inflammatory markers in older adults. METHODS: We enrolled 1798 inhabitants of I-Lan County of Taiwan (855 men, 47.5%; mean age 64 ± 9 years, range 50-92 years)...
July 4, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28646836/biochemical-parameters-as-monitoring-markers-of-the-inflammatory-reaction-by-patients-with-chronic-obstructive-pulmonary-disease-copd
#3
Petra Lenártová, Jana Kopčeková, Martina Gažarová, Jana Mrázová, Joanna Wyka
Background: Chronic obstructive pulmonary disease (COPD) is an airway inflammatory disease caused by inhalation of toxic particles, mainly cigarette smoking, and now is accepted as a disease associated with systemic characteristics. Objective: The aim of this work was to investigate and compare selected biochemical parameters in patients with and without COPD. Material and Methods: Observation group consisted of clinically stable patients with COPD (n = 60)...
2017: Roczniki Państwowego Zakładu Higieny
https://www.readbyqxmd.com/read/28645281/sex-difference-in-the-risk-for-exercise-induced-albuminuria-correlates-with-hemoglobin-a1c-and-abnormal-exercise-ecg-test-findings
#4
Rafael Y Brzezinski, Inbal Etz-Hadar, Ayelet Grupper, Michal Ehrenwald, Itzhak Shapira, David Zeltser, Shlomo Berliner, Ori Rogowski, Roy Eldor, Shani Shenhar-Tsarfaty
BACKGROUND: Albuminuria is an established marker for endothelial dysfunction and cardiovascular risk in diabetes and prediabetes. Exercise induced albuminuria (EiA) appears earlier and may be a more sensitive biomarker for renal endothelial damage. We sought to examine the association between EiA, parameters of the metabolic syndrome, A1C levels, exercise ECG test results and sex related differences in a large cohort of healthy, pre-diabetic and diabetic subjects. METHODS: A total of 3029 participants from the Tel-Aviv Medical Center Inflammation Survey cohort (mean age 46 years, 73% men) were analyzed...
June 23, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28606860/effects-of-partial-replacement-of-fish-meal-by-yeast-hydrolysate-on-complement-system-and-stress-resistance-in-juvenile-jian-carp-cyprinus-carpio-var-jian
#5
Xiang-Yang Yuan, Wen-Bin Liu, Chao Liang, Cun-Xin Sun, Yun-Fei Xue, Zu-De Wan, Guang-Zhen Jiang
A 10-week feeding trial was carried out to investigate the effects of dietary fish meal replacement by yeast hydrolysate (YH) on growth performance, complement system and stress resistance of juvenile Jian carp (Cyprinus carpio var. Jian) (initial average weight 19.44 ± 0.06 g). In the study, there were five groups: one control group was fed with a basal diet (YH0), and four treatment groups were fed with dietary fish meal replaced by 1% YH (YH1), 3% (YH3), 5% (YH5) and 7% (YH7), respectively. Each group had four replicates...
August 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28550800/2-phthalimidethanol-and-2-phthalimidethyl-nitrate-inhibit-mechanical-allodynia-neutrophil-recruitment-and-cytokine-and-chemokine-production-in-a-murine-model-of-articular-inflammation
#6
Adriana M Godin, Débora P Araújo, Raquel R Menezes, Ana M S de Brito, Ivo S F Melo, Giovanna M E Coura, Leandro F S Bastos, Flávio A Amaral, Mauro M Teixeira, Ângelo de Fátima, Márcio M Coelho, Renes R Machado
BACKGROUND: Phthalimide analogs have been shown to exhibit anti-inflammatory, analgesic and immunomodulatory activities in different preclinical assays. This study aimed to investigate the potential role of 2-phthalimidethanol (PTD-OH) and 2-phthalimidethyl nitrate (PTD-NO) in a murine model of antigen-induced articular inflammation. METHODS: Articular inflammation was induced by intra-articular injection of methylated bovine serum albumin (mBSA) in the knee joint of immunized male C57BL/6J mice...
February 8, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28397820/bitter-taste-receptor-agonists-mitigate-features-of-allergic-asthma-in-mice
#7
Pawan Sharma, Roslyn Yi, Ajay P Nayak, Nadan Wang, Francesca Tang, Morgan J Knight, Shi Pan, Brian Oliver, Deepak A Deshpande
Asthma is characterized by airway inflammation, mucus secretion, remodeling and hyperresponsiveness (AHR). Recent research has established the bronchodilatory effect of bitter taste receptor (TAS2R) agonists in various models. Comprehensive pre-clinical studies aimed at establishing effectiveness of TAS2R agonists in disease models are lacking. Here we aimed to determine the effect of TAS2R agonists on features of asthma. Further, we elucidated a mechanism by which TAS2R agonists mitigate features of asthma...
April 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28293450/il-17a-levels-in-systemic-lupus-erythematosus-associated-with-inflammatory-markers-and-lower-rates-of-malignancy-and-heart-damage-evidence-for-a-dual-role
#8
Warren Raymond, Gro Ostli-Eilertsen, Sheynae Griffiths, Johannes Nossent
OBJECTIVE: The interleukin 17 (IL-17) cytokine family is involved in a number of chronic inflammatory diseases. In spite of contradictory findings and a lack of causality in clinical studies, IL-17 inhibition for systemic lupus erythematosus (SLE) has regained attention as a potential therapeutic pathway, after demonstrating disease-modifying capabilities in ankylosing spondylitis. We investigated the clinical associations of interleukin 17 A (IL-17A) in patients with SLE. MATERIAL AND METHODS: A cross-sectional study was performed involving SLE patients (n=102; age: 49 years; 86% female) recruited from a regional registry...
March 2017: European Journal of Rheumatology
https://www.readbyqxmd.com/read/28258441/tnf-%C3%AE-il-6-and-il-10-expressions-responsible-for-disparity-in-action-of-curcumin-against-cisplatin-induced-nephrotoxicity-in-rats
#9
Parveen Kumar, Kunjbihari Sulakhiya, Chandana C Barua, Nitin Mundhe
Cisplatin is a regularly employed effective chemotherapeutic agent for the treatment of many types of cancer. The main drawback of cisplatin treatment is kidney toxicity which affects 25-35% of treated patients. Many mechanisms are believed to be involved in this kidney damage, but inflammation plays a significant role in this event. Curcumin is a polyphenol and has antioxidant and anti-inflammatory effects. The purpose of this study was to determine the protective effects of curcumin on cisplatin-induced nephrotoxicity...
March 3, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28237915/hepatoprotective-activity-of-butea-monosperma-bark-against-thioacetamide-induced-liver-injury-in-rats
#10
Varinder Kaur, Manish Kumar, Paramjeet Kaur, Sandeep Kaur, Amrit Pal Singh, Satwinderjeet Kaur
For thousands of years, the plant-based natural products have been a source of curative agents for various ailments. Butea monosperma (Fabaceae) has an important place in Indian traditional system of medicine for curing number of disorders. The present study deals with evaluation of hepatoprotective properties of ethyl acetate fraction (Beac) from B. monosperma bark in rat model. In preliminary antioxidant studies, Beac demonstrated pronounced superoxide scavenging (IC50 88.85μg/ml) and anti-lipid peroxidation (IC50 131...
May 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28127532/plasma-protein-bound-di-tyrosines-as-biomarkers-of-oxidative-stress-in-end-stage-renal-disease-patients-on-maintenance-haemodialysis
#11
Graziano Colombo, Francesco Reggiani, David Cucchiari, Nicola M Portinaro, Daniela Giustarini, Ranieri Rossi, Maria Lisa Garavaglia, Nicola Saino, Aldo Milzani, Salvatore Badalamenti, Isabella Dalle-Donne
BACKGROUND: Patients with end-stage renal disease (ESRD) undergoing haemodialysis (HD) experience enhanced oxidative stress and systemic inflammation, which are risk factors for cardiovascular disease, the most common cause of excess morbidity and mortality for these patients. Different pathways producing different types of oxidative stress occur in ESRD. The purpose of our study was to determine the effect of HD on plasma levels of protein-bound dityrosine (di-Tyr), a biomarker of protein oxidation...
June 2017: BBA Clinical
https://www.readbyqxmd.com/read/28114138/plasma-gelsolin-and-its-association-with-mortality-and-hospitalization-in-chronic-hemodialysis-patients
#12
Cesar Flores Gama, Laura M Rosales, Georges Ouellet, Yanna Dou, Stephan Thijssen, Len Usvyat, Hanjie Zhang, Viktoriya Kuntsevich, Nathan W Levin, Peter Kotanko
BACKGROUND: Human plasma gelsolin (pGSN) is an actin-binding protein that is secreted into the extracellular fluid, with the skeletal muscle and myocardial tissues being its major source. Depletion of pGSN has been shown to be related to a variety of inflammatory and clinical conditions. METHODS: pGSN levels were prospectively determined in prevalent maintenance hemodialysis (HD) patients from 3 U.S. dialysis centers. Demographics (age, time since dialysis initiation, race, gender, body height and weight, comorbidities), inflammatory markers (C reactive protein, CRP; interleukin 6, IL-6), free triiodothyronine (fT3), and routine laboratory parameters were obtained...
2017: Blood Purification
https://www.readbyqxmd.com/read/28109602/strategies-to-gain-body-condition-score-in-pasture-based-dairy-cows-during-late-lactation-and-the-far-off-nonlactating-period-and-their-interaction-with-close-up-dry-matter-intake
#13
RANDOMIZED CONTROLLED TRIAL
J R Roche, A Heiser, M D Mitchell, M A Crookenden, C G Walker, J K Kay, M Vailati Riboni, J J Loor, S Meier
In pasture-based systems, cows are generally thinner at the end of lactation than cows fed total mixed rations and, as a result, over-feeding of metabolizable energy (ME) during the far-off nonlactating period is a standard management policy to achieve optimum calving body condition score (BCS). An alternative would be to manage cows to gain BCS through late lactation, such that cows ended lactation close to optimum calving BCS and maintenance of BCS through to calving. We sought to quantify the effect of moderate or excessive ME intakes during the far-off nonlactating period in cows that had been managed to gain or maintain BCS through late lactation and whether the far-off management strategy interacted with close-up level of feeding...
March 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28086980/inflammation-in-epileptogenesis-after-traumatic-brain-injury
#14
REVIEW
Kyria M Webster, Mujun Sun, Peter Crack, Terence J O'Brien, Sandy R Shultz, Bridgette D Semple
BACKGROUND: Epilepsy is a common and debilitating consequence of traumatic brain injury (TBI). Seizures contribute to progressive neurodegeneration and poor functional and psychosocial outcomes for TBI survivors, and epilepsy after TBI is often resistant to existing anti-epileptic drugs. The development of post-traumatic epilepsy (PTE) occurs in a complex neurobiological environment characterized by ongoing TBI-induced secondary injury processes. Neuroinflammation is an important secondary injury process, though how it contributes to epileptogenesis, and the development of chronic, spontaneous seizure activity, remains poorly understood...
January 13, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28075404/advanced-oxidation-protein-products-modified-albumin-induces-differentiation-of-raw264-7-macrophages-into-dendritic-like-cells-which-is-modulated-by-cell-surface-thiols
#15
Silvano Garibaldi, Chiara Barisione, Barbara Marengo, Pietro Ameri, Claudio Brunelli, Manrico Balbi, Giorgio Ghigliotti
Local accumulation of Advanced Oxidation Protein Products (AOPP) induces pro-inflammatory and pro-fibrotic processes in kidneys and is an independent predictor of renal fibrosis and of rapid decline of eGFR in patients with chronic kidney disease (CKD). In addition to kidney damage, circulating AOPP may be regarded as mediators of systemic oxidative stress and, in this capacity, they might play a role in the progression of atherosclerotic damage of arterial walls. Atherosclerosis is a chronic inflammatory disease that involves activation of innate and adaptive immunity...
January 10, 2017: Toxins
https://www.readbyqxmd.com/read/27834982/telmisartan-decreases-microalbuminuria-in-patients-with-type-2-diabetes-mellitus-following-coronary-artery-bypass-grafting
#16
Cevdet Furat, Riza Dogan, Gokhan Ilhan, Ekrem Bayar, Berkan Ozpak, Hakan Kara, Şahin Bozok
OBJECTIVE: This prospective study aimed to investigate the effects of the selective angiotensin receptor antagonist, telmisartan, on microalbuminuria after coronary artery bypass surgery in patients with diabetes mellitus. METHODS: Patients were divided into two groups with block randomisation, using the sealed envelope technique: group T (telmisartan group) consisted of patients who received the angiotensin receptor blocking agent telmisartan 80 mg daily for at least six months in the pre-operative period; group N-T (non-telmisartan group) consisted of patients who received no telmisartan treatment...
November 10, 2016: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/27798896/pro-inflammatory-state-portends-poor-outcomes-with-stereotactic-radiosurgery-for-brain-metastases
#17
Narek Shaverdian, Jason Wang, Rebecca Levin-Epstein, Dorthe Schaue, Patrick Kupelian, Percy Lee, Isaac Yang, Tania Kaprealian
AIM: We determined if pre-treatment systemic inflammation would predict poor outcomes in the setting of stereotactic radiosurgery (SRS) for brain metastases. PATIENTS AND METHODS: The pretreatment albumin concentration, neutrophil and lymphocyte counts, and the platelet-to-lymphocyte ratio (PLR) were evaluated to determine association with intracranial control, local control (LC), initial MRI response (MR), and overall survival (OS) among 70 patients with 152 separate brain metastases treated with SRS alone from 2008-2015...
2016: Anticancer Research
https://www.readbyqxmd.com/read/27797973/integrative-systemic-and-local-metabolomics-with-impact-on-survival-in-high-grade-serous-ovarian-cancer
#18
Anna Bachmayr-Heyda, Stefanie Aust, Katharina Auer, Samuel M Meier, Klaus G Schmetterer, Sabine Dekan, Christopher Gerner, Dietmar Pils
Purpose: Cancer metabolism is characterized by alterations including aerobic glycolysis, oxidative phosphorylation, and need of fuels and building blocks.Experimental Design: Targeted metabolomics of preoperative and follow-up sera, ascites, and tumor tissues, RNA sequencing of isolated tumor cells, local and systemic chemokine, and local immune cell infiltration data from up to 65 high-grade serous ovarian cancer patients and 62 healthy controls were correlated to overall survival and integrated in a Systems Medicine manner...
April 15, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27553641/pharmacological-value-of-murine-delayed-type-hypersensitivity-arthritis-a-robust-mouse-model-of-rheumatoid-arthritis-in-c57bl-6-mice
#19
REVIEW
Sara Marie Atkinson, Anneline Nansen
In this MiniReview, we summarize the body of knowledge on the delayed-type hypersensitivity arthritis (DTHA) model, a recently developed arthritis model with 100% incidence, low variation and synchronized onset in C57BL/6 (B6) mice, and compare it to other murine arthritis models. It is desirable to have robust arthritis models in B6 mice, as many transgene strains are bred on this background. However, several of the most widely used mouse model of arthritis cannot be induced in B6 mice without the drawback of lower incidence, reduced severity and higher variation, if at all...
February 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/27312339/long-term-exposure-to-abnormal-glucose-levels-alters-drug-metabolism-pathways-and-insulin-sensitivity-in-primary-human-hepatocytes
#20
Matthew D Davidson, Kimberly R Ballinger, Salman R Khetani
Hyperglycemia in type 2 diabetes mellitus has been linked to non-alcoholic fatty liver disease, which can progress to inflammation, fibrosis/cirrhosis, and hepatocellular carcinoma. Understanding how chronic hyperglycemia affects primary human hepatocytes (PHHs) can facilitate the development of therapeutics for these diseases. Conversely, elucidating the effects of hypoglycemia on PHHs may provide insights into how the liver adapts to fasting, adverse diabetes drug reactions, and cancer. In contrast to declining PHH monocultures, micropatterned co-cultures (MPCCs) of PHHs and 3T3-J2 murine embryonic fibroblasts maintain insulin-sensitive glucose metabolism for several weeks...
2016: Scientific Reports
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