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Emergency cerebrovascular

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https://www.readbyqxmd.com/read/29898464/impact-of-different-aortic-entry-tear-sites-on-early-outcomes-and-long-term-survival-in-patients-with-stanford-a-acute-aortic-dissection
#1
Julia Merkle, Anton Sabashnikov, Antje Christin Deppe, Saskia Weber, Navid Mader, Yeong-Hoon Choi, Oliver Liakopoulos, Ferdinand Kuhn-Régnier, Thorsten Wahlers
BACKGROUND:  Stanford A acute aortic dissection (AAD) is a life-threatening emergency. The aim of this study was to compare the impact of three different aortic entry tear sites on early outcomes and long-term survival of patients with Stanford A AAD. METHODS:  From January 2006 to April 2015, a total of 240 consecutive patients with diagnosed Stanford A AAD underwent emergent, isolated surgical aortic repair in our center. Patients were divided into three groups comprising isolated ascending aorta, proximal aortic arch, and distal aortic arch entry tear site and were followed up for up to 9 years...
June 13, 2018: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/29896421/age-dependent-decrease-in-adropin-is-associated-with-reduced-levels-of-endothelial-nitric-oxide-synthase-and-increased-oxidative-stress-in-the-rat-brain
#2
Changjun Yang, Kelly M DeMars, Eduardo Candelario-Jalil
Adropin is a peptide highly expressed in the brain. Emerging evidence indicates that low plasma levels of adropin are closely associated with aging and endothelial dysfunction. We hypothesized that aging reduces adropin levels in the brain, which correlates with reduced endothelial nitric oxide synthase (eNOS) and increased oxidative stress associated with age-related endothelial dysfunction. Cortical brain tissue and plasma were collected from young (10-12 weeks old) and aged (18-20 months old) male Sprague-Dawley naïve rats...
April 2018: Aging and Disease
https://www.readbyqxmd.com/read/29894303/exposure-to-indoor-radon-can-be-a-concern-in-studies-on-the-role-of-short-term-exposure-to-air-pollution-and-mortality
#3
S M J Mortazavi
Recent studies show that short-term exposure to ambient particulate matter is associated with more emergency department visits and hospitalizations for pneumonia as well as increased mortality and increased health care costs among older adults. Moreover, exposure to ambient particulate matter is shown to be connected with an increased rate of daily mortality and hospitalizations due to cardiovascular diseases (CVDs). The association between short-term exposures to particulate matter with a diameter less than 2...
June 12, 2018: Reviews on Environmental Health
https://www.readbyqxmd.com/read/29889275/myopericytoma-at-the-craniocervical-junction-clinicopathological-report-and-review-of-a-rare-perivascular-neoplasm
#4
Jimmy C Yang, Andrew S Venteicher, Matthew J Koch, Christopher J Stapleton, Gabriel N Friedman, Emma M Venteicher, John H Shin
BACKGROUND AND IMPORTANCE: Myopericytoma is an emerging class of neoplasm originating from the perivascular myoid cellular environment, previously classified as a variant of hemangiopericytoma. Most reported myopericytomas are found in soft tissues of the extremities; however, infrequent cases are described involving the central nervous system. Intracranial myopericytoma remains rare. Here, we describe the first report of myopericytoma occurring at the cervicomedullary junction in close proximity to the vertebral artery, mimicking a vascular lesion...
June 8, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29878487/chronic-oral-infection-an-emerging-risk-factor-of-cerebral-small-vessel-disease
#5
REVIEW
Ghazal Aarabi, Götz Thomalla, Guido Heydecke, Udo Seedorf
Chronic oral infections (gingivitis/periodontitis) have been associated with age-related diseases such as diabetes, coronary heart disease and acute ischemic stroke. In addition, imaging surrogates of cerebrovascular ischemia beyond acute ischemic stroke (i.e. silent strokes and brain white matter hyperintensities) may also be associated with chronic oral infections. The pathology underlying lacunar strokes and brain white matter hyperintensities relates to small vessel disease in the brain. In this review, we highlight recent progress in exploring potential associations of oral infections with cerebral small vessel disease and its surrogates (silent strokes, white matter hyperintensities) and clinical sequelae (i...
June 7, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29863415/preoperative-intraaortic-balloon-pump-before-urgent-coronary-bypass-grafting
#6
Ingo Slottosch, Oliver Liakopoulos, Maximilian Scherner, Elmar Kuhn, Antje-Christin Deppe, Max Wacker, Jens Wippermann, Thorsten Wahlers
Background Urgent or emergency coronary artery bypass grafting in patients with acute coronary syndrome is associated with increased morbidity and mortality. We investigated the effects of preoperative intraaortic balloon pump support in this high-risk patient cohort. Methods Our institutional database was retrospectively reviewed for patients with acute coronary syndrome and an urgent or emergency indication for coronary artery bypass from April 2010 to December 2016. Data of 1066 patients were analyzed. We assessed the impact of preoperative intraaortic balloon pump therapy on postoperative mortality and major adverse cardiovascular and cerebrovascular events, and performed propensity-score matching...
January 1, 2018: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/29846990/aging-and-vascular-related-pathologies
#7
Shu Wen Wen, Connie H Y Wong
Our aging population is set to grow considerably in the coming decades. In fact, the number of individuals older than 65 years will double by 2050. This projected increase of people living with extended life expectancy represents an inevitable upsurge in the presentation of age-related pathologies. However, our current understanding of the impact of aging on a number of biological processes is unfortunately inadequate. Cardiovascular, cerebrovascular and neurodegenerative diseases are particularly prevalent in the elderly population...
May 30, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29806779/geographic-analysis-of-road-accident-severity-index-in-nigeria
#8
Ayodeji E Iyanda
Before 2030, deaths from road traffic accidents (RTAs) will surpass cerebrovascular disease, tuberculosis, and HIV/AIDS. Yet, there is little knowledge on the geographic distribution of RTA severity in Nigeria. Accident Severity Index is the proportion of deaths that result from a road accident. This study analysed the geographic pattern of RTA severity based on the data retrieved from Federal Road Safety Corps (FRSC). The study predicted a two-year data from a historic road accident data using exponential smoothing technique...
May 28, 2018: International Journal of Injury Control and Safety Promotion
https://www.readbyqxmd.com/read/29783250/-signifuing-resident-of-the-city-poltava-at-the-expense-of-signs-stroke-risk-factors-and-urgent-measures-according-to-medico-social-survey
#9
Anzhelina M Kryvchun, Nataliia V Lytvynenko, Viktoriia A Pinchuk, Galyna Ya Sylenko, Viktoriia M Gladka
OBJECTIVE: Introduction: The problem of cerebrovascular diseases and their most severe form - cerebral stroke is one of the most pressing problems in modern medicine due to the high level of lethality, significant disability of patients. The aim: To assess and increase the sign of residents of the city Poltava at the expense of signs of stroke, its risk factors for emergence and emergency measures for stroke. PATIENTS AND METHODS: Materials and methods: During the annual social event dedicated to the World Stroke Day, on October 27, 2017, a survey of 981 people in Poltava city was conducted by volunteer students and staff of the Department of Nervous Diseases with Neurosurgery and Medical Genetics of "Ukrainian Medical Stomatological Academy"...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29755709/perioperative-management-of-sickle-cell-disease
#10
REVIEW
Kwame Ofori Adjepong, Folashade Otegbeye, Yaw Amoateng Adjepong
Over 30 million people worldwide have sickle cell disease (SCD). Emergent and non-emergent surgical procedures in SCD have been associated with relatively increased risks of peri-operative mortality, vaso-occlusive (painful) crisis, acute chest syndrome, post-operative infections, congestive heart failure, cerebrovascular accident and acute kidney injury. Pre-operative assessment must include a careful review of the patient's known crisis triggers, baseline hematologic profile, usual transfusion requirements, pre-existing organ dysfunction and opioid use...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/29739805/igf-1-the-jekyll-hyde-of-the-aging-brain
#11
Sriram Gubbi, Gabriela Farias Quipildor, Nir Barzilai, Derek M Huffman, Sofiya Milman
The IGF-1 signaling pathway has emerged as a major regulator of the aging process, from rodents to humans. However, given the pleiotropic actions of IGF-1, its role in the aging brain remains complex and controversial. While IGF-1 is clearly essential for normal development of the central nervous system, conflicting evidence has emerged from preclinical and human studies regarding its relationship to cognitive function, as well as cerebrovascular and neurodegenerative disorders. This review delves into the current state of the evidence examining the role of IGF-1 in the aging brain, encompassing preclinical and clinical studies...
May 8, 2018: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/29725183/dihydroergotamine-complicating-reversible-cerebral-vasoconstriction-syndrome-in-status-migrainosus
#12
Naresh Mullaguri, Madihah Hepburn, Christopher Ryan Newey, Premkumar Chandrasekharan Nattanmai
Reversible cerebral vasoconstriction syndrome (RCVS) is a clinicoradiological syndrome that occurs due to dysfunction of cerebrovascular autoregulation. It is characterized by recurrent thunderclap headache from cerebral vasoconstriction which can cause ischemic infarction, spontaneous intraparenchymal and subarachnoid hemorrhage. This syndrome can be triggered by a variety of etiologies including medications, infectious, and inflammatory conditions. The diagnosis is often delayed due to unawareness among the health-care providers and delayed neuroimaging evidence of vasoconstriction with or without ischemic and/or hemorrhagic infarction...
April 2018: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/29721613/identification-of-dizzy-patients-who-will-develop-an-acute-cerebrovascular-syndrome-a-descriptive-study-among-emergency-department-patients
#13
I Mármol-Szombathy, E Domínguez-Durán, L Calero-Ramos, S Sánchez-Gómez
PURPOSE: To calculate the incidence of subsequent acute cerebrovascular syndrome in emergency department patients with vertigo or dizziness symptoms and to determine predictors of subsequent acute cerebrovascular syndrome in these patients. METHODS: Descriptive and retrospective hospital based-population study among emergency department patients with vertigo or dizziness symptoms in 1 year. One year follow-up since the medical visit was performed. Chi-square and Fisher tests were used for qualitative variables; Mann-Whitney U test for quantitative variables...
May 2, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29718780/isoprenoids-and-protein-prenylation-implications-in-the-pathogenesis-and-therapeutic-intervention-of-alzheimer-s-disease
#14
Angela Jeong, Kiall Francis Suazo, W Gibson Wood, Mark D Distefano, Ling Li
The mevalonate-isoprenoid-cholesterol biosynthesis pathway plays a key role in human health and disease. The importance of this pathway is underscored by the discovery that two major isoprenoids, farnesyl and geranylgeranyl pyrophosphate, are required to modify an array of proteins through a process known as protein prenylation, catalyzed by prenyltransferases. The lipophilic prenyl group facilitates the anchoring of proteins in cell membranes, mediating protein-protein interactions and signal transduction...
June 2018: Critical Reviews in Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29717825/treatment-of-nonarteritic-acute-central-retinal-artery-occlusion
#15
Rahul A Sharma, Michael Dattilo, Nancy J Newman, Valerie Biousse
Central retinal artery occlusion (CRAO) is an event most often caused by an embolus originating in the ipsilateral carotid artery, aortic arch, or heart. CRAO may result from partial or complete occlusion of the central retinal artery (CRA), which acts as the primary blood supply to the inner neurosensory retina, and typically results in profound vision loss and permanent visual disability. No consensus has emerged regarding the optimal treatment of CRAO. All proposed treatments are of questionable efficacy and many have uncertain risk profiles...
May 2, 2018: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/29713575/an-evaluation-of-complications-in-femoral-arterial-sheaths-maintained-post-neuroangiographic-procedures
#16
Zalan Khan, Premkumar Nattanamai, Premkumar Keerthivaas, Christopher R Newey
BACKGROUND: Digital subtraction angiography (DSA) is a frequently used technique in the neuro-diagnosis and treatment of cerebrovascular diseases. The routine use of femoral arterial sheaths (FAS) peri-procedurally has become standard. The maintenance of a FAS post-procedure may be warranted while awaiting the normalization of coagulopathy or to reaccess emergently. We retrospectively reviewed our stroke dataset to evaluate for complications associated with the prolonged use of FAS post-procedure...
February 26, 2018: Curēus
https://www.readbyqxmd.com/read/29701349/pulmonary-hypertension-in-valvular-heart-disease-surgery-risk-and-prognosis
#17
Márcio Madeira, Sara Ranchordás, Paulo Oliveira, Tiago Nolasco, Marta Marques, Luis Bruges, José Calquinha, Miguel Sousa Uva, Miguel Abecasis, José Pedro Neves
INTRODUCTION: Left heart disease is the most common cause of pulmonary hypertension (PH), and when present is associated with higher surgical risk. OBJECTIVES: Analyze the effect of PH severity on morbidity, early and late mortality in patients with pulmonary artery systolic pressure (PASP) over 30mmHg that underwent valvular heart surgery. METHODS: Retrospective observational study including all patients with PH, defined as PASP>30 mmHg that underwent isolated valvular heart surgery, between 2007 and 2016...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29700768/proteomic-analysis-of-cerebral-cortex-extracts-from-sus-scrofa-with-induced-hemorrhagic-stroke
#18
Alexander A Sidyakin, Anna L Kaysheva, Artur T Kopylov, Alexander V Lobanov, Sergei G Morozov
Cerebrovascular diseases, including stroke and micro stroke, are the main causes of death in contemporary society. Hemorrhagic stroke is the fast emerging defficiency in the brain function resulting from disturbance of blood supply to the brain caused by the rapture of blood vessels (Lopez et al. in Proteomics Clin Appl 6:190-200, 2012). The influence of a model hemorrhagic stroke on white pigs with the change in the protein profile of their cortical samples 24 h and 2 months after the stroke was examined using mass-spectrometric analysis...
April 26, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29691276/asia-pacific-working-group-consensus-on-non-variceal-upper-gastrointestinal-bleeding-an-update-2018
#19
Joseph Jy Sung, Philip Cy Chiu, Francis K L Chan, James Yw Lau, Khean-Lee Goh, Lawrence Hy Ho, Hwoon-Young Jung, Jose D Sollano, Takuji Gotoda, Nageshwar Reddy, Rajvinder Singh, Kentaro Sugano, Kai-Chun Wu, Chun-Yin Wu, David J Bjorkman, Dennis M Jensen, Ernst J Kuipers, Angel Lanas
Non-variceal upper gastrointestinal bleeding remains an important emergency condition, leading to significant morbidity and mortality. As endoscopic therapy is the 'gold standard' of management, treatment of these patients can be considered in three stages: pre-endoscopic treatment, endoscopic haemostasis and post-endoscopic management. Since publication of the Asia-Pacific consensus on non-variceal upper gastrointestinal bleeding (NVUGIB) 7 years ago, there have been significant advancements in the clinical management of patients in all three stages...
April 24, 2018: Gut
https://www.readbyqxmd.com/read/29689727/vascular-cognitive-impairment-and-the-gut-microbiota
#20
Sinian Li, Yiming Shao, Kanglan Li, Changmei HuangFu, Wenjie Wang, Zhou Liu, Zhiyou Cai, Bin Zhao
Vascular cognitive impairment (VCI), the second most common cause of dementia in elderly people, is a term that refers to all forms of cognitive disorders that can be attributed to cerebrovascular disease such as manifestations of discrete infarctions, brain hemorrhages, and white matter lesions. The gut microbiota (GM) has emerged recently as an essential player in the development of VCI. The GM may affect the brain's physiological, behavioral, and cognitive functions through the brain-gut axis via neural, immune, endocrine, and metabolic pathways...
April 17, 2018: Journal of Alzheimer's Disease: JAD
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