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https://www.readbyqxmd.com/read/29451522/-management-of-benign-esophageal-strictures-a-literature-review
#1
Leonardo Frazzoni, Marina La Marca, Amedeo Montale, Lorenzo Fuccio
The management of benign esophageal strictures is challenging. The first strategy includes endoscopic dilation using bougies or balloons. Although the immediate success rate of these is up to 90%, about 30-40% of patients experience recurrent dysphagia within the first year of follow-up. The management of refractory stenosis involves repeated sessions of endoscopic dilation. In order to obtain long-lasting functional results, alternative treatments have been developed, such as the use of self-expanding stents, particularly indicated in subgroups of patients with post-surgical stenosis or post-radiation therapy...
January 2018: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/29437006/enteral-administration-of-tkis-report-of-a-response-to-ceritinib-in-an-alk-positive-nsclc-patient-and-literature-review
#2
Francesco Facchinetti, Paola Bordi, Paola Bini, Livia Bidin, Roberta Camisa, Marcello Tiseo
INTRODUCTION: Several reports attest the feasibility and the favorable outcomes of kinase inhibitors administration through feeding tubes or percutaneous endoscopic gastrostomies (PEG), mainly in non-small cell lung cancer (NSCLC) patients exposed to first-generation compounds. Here we present the case of an ALK-positive NSCLC patient who achieved cerebral and extra-cranial disease response with ceritinib (a novel ALK inhibitor) administered through a nasogastric tube (NGT). We moreover provide a review gathering clinical successes obtained with targeted agents intake through NGT or PEG...
February 12, 2018: Current Drug Targets
https://www.readbyqxmd.com/read/29399615/initial-experience-with-percutaneous-endoscopic-gastrostomy-with-t-fastener-fixation-in-pediatric-patients
#3
Morten Kvello, Charlotte Kristensen Knatten, Gøri Perminow, Hans Skari, Anders Engebretsen, Ole Schistad, Ragnhild Emblem, Kristin Bjørnland
Background and study aims:  Insertion of a percutaneous endoscopic gastrostomy (PEG) with push-through technique and T-fastener fixation (PEG-T) has recently been introduced in pediatric patients. The T-fasteners allow a primary insertion of a balloon gastrostomy. Due to limited data on the results of this technique in children, we have investigated peri- and postoperative outcomes after implementation of PEG-T in our department. Patients and methods:  This retrospective chart review included all patients below 18 years who underwent PEG-T placement from 2010 to 2014...
February 2018: Endoscopy International Open
https://www.readbyqxmd.com/read/29397032/impact-of-gastrostomy-feeding-tube-placement-on-the-1-year-trajectory-of-care-in-patients-after-stroke
#4
Janina Wilmskoetter, Annie N Simpson, Sarah L Logan, Kit N Simpson, Heather S Bonilha
BACKGROUND: Percutaneous endoscopic gastrostomy (PEG) feeding tubes are commonly placed in acute stroke patients with a need for enteral nutrition. However, PEG tubes are associated with medical complications and a decrease in quality of life. We compared the 1-year care trajectory of stroke patients with and without PEG tube placement to enhance knowledge about the long-term impact of PEG tube placement. METHODS: We conducted a retrospective analysis of commercially insured stroke patients included in the Truven Health MarketScan Research Databases of 2011...
February 3, 2018: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/29389058/endoscopic-suturing-for-the-management-of-recurrent-peg-j-tube-dislodgment
#5
Abhishek Agnihotri, Sindhu Barola, Christine Hill, Priya Mishra, Lea Fayad, Margo Dunlap, Robert A Moran, Vikesh K Singh, Anthony N Kalloo, Mouen A Khashab, Vivek Kumbhari
BACKGROUND: We describe a novel technique for the prevention of recurrent percutaneous endoscopic gastrostomy with jenunal extension (PEG-J) tube dislodgements. This technique utilizes endoscopic suturing to secure the PEG-J tube to the gastric wall. The aim of this study is to assess technical feasibility and efficacy. METHODS: This is a retrospective analysis of consecutive cases of recurrent inadvertent PEG-J tube dislodgements referred to a single endoscopist between June 2016 and June 2017...
February 1, 2018: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/29369238/to-pull-or-to-scope-a-prospective-safety-and-cost-effectiveness-of-percutaneous-endoscopic-gastrostomy-tube-replacement-methods
#6
Tawfik Khoury, Saleh Daher, Shaul Yaari, Ayman Abu Rmeileh, Eran Israeli, Ariel A Benson, Jonah Cohen, Ron Arnon, Meir Mizrahi
BACKGROUND: Percutaneous endoscopic gastrostomy (PEG) tubes are routinely used as an effective method for providing enteral nutrition. The need for their exchange is common. GOALS: We aimed to examine the comparative safety and cost-effectiveness of PEG percutaneous counter-traction "pulling" approach or by endoscopically guided retrieval. STUDY: A prospective 215 consecutive patients undergoing PEG tube insertion were included. Fifty patients in total were excluded...
January 23, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29361810/-clinical-course-of-percutaneous-endoscopic-gastrostomy-a-single-center-observational-study
#7
Jihyun Lee, Ki Nam Shim, Kang Hoon Lee, Ko Eun Lee, Ji Young Chang, Chung Hyun Tae, Chang Mo Moon, Seong Eun Kim, Hye Kyung Jung, Sung Ae Jung
Background/Aims: Percutaneous endoscopic gastrostomy (PEG) is a widely used method for long-term tube feeding. This study aimed to investigate the clinical characteristics and outcomes of patients who utilized long-term feeding tube via PEG. Methods: The medical records of 137 patients who underwent PEG tube insertion at Ewha Womans University Mokdong Hospital between January 2002 and December 2013 were reviewed. Results: PEG was indicated most frequently for cerebrovascular accidents (66 patients, 48...
January 25, 2018: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/29351343/minority-race-and-male-sex-as-risk-factors-for-non-beneficial-gastrostomy-tube-placements-after-stroke
#8
Roland Faigle, Joseph A Carrese, Lisa A Cooper, Victor C Urrutia, Rebecca F Gottesman
BACKGROUND: Percutaneous endoscopic gastrostomy (PEG) tubes are widely used for enteral feeding after stroke; however, PEG tubes placed in patients in whom death is imminent are considered non-beneficial. AIM: We sought to determine whether placement of non-beneficial PEG tubes differs by race and sex. DESIGN AND SETTING/PARTICIPANTS: In this retrospective cohort study, inpatient admissions for stroke patients who underwent palliative/withdrawal of care, were discharged to hospice, or died during the hospitalization, were identified from the Nationwide Inpatient Sample between 2007 and 2011...
2018: PloS One
https://www.readbyqxmd.com/read/29349584/-percutaneous-endoscopic-gastrostomy-in-geriatrics-indications-technique-and-complications
#9
Rainer Wirth
The technique of percutaneous endoscopic gastrostomy (PEG) was introduced in 1979 as a semi-invasive approach for children with the need for a gastric fistula in order to avoid an operative intervention. The suture pull-through method was rapidly established and is now omnipresent. Because scientific evidence is broadly missing, there is some uncertainty about the indications in geriatric medicine. Guidelines do not recommend the insertion of a PEG in patients with severe dementia and malnutrition. Tube feeding is mainly recommended as a temporary method for patients who cannot take oral nutrition for more than 3 days or for whom the energy intake for more than 10 days presumably covers less than 50% of their needs, assuming that the overall prognosis is reasonable...
January 18, 2018: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/29340295/usage-characteristics-and-adverse-event-rates-%C3%A2-of-the-direct-puncture-and-pull-techniques-for-percutaneous-endoscopic-gastrostomy-in-patients-with-malignant-tumors-of-the-upper-aerodigestive-tract
#10
Niels Teich, Lars Selig, Susanne Liese, Franziska Schiefke, Alexander Hemprich, Joachim Mössner, Ingolf Schiefke
Background and study aims:  Patients with malignant tumors of the upper gastrointestinal tract are at risk of weight loss. Early supportive nutrition therapy is therefore recommended and usually requires placement of a percutaneous endoscopic gastrostomy (PEG). The aim of this study was to compare adverse events and usage characteristics of the direct puncture technique with those of the traditional pull technique when used in patients with endoscopically passable tumors. The primary endpoint was the rate of inflammatory adverse events (AEs) at the gastrostomy fistula...
January 2018: Endoscopy International Open
https://www.readbyqxmd.com/read/29326482/compounded-apixaban-suspensions-for-enteral-feeding-tubes
#11
Maria L Caraballo, Seda Donmez, Kobi Nathan, Fang Zhao
Objective: There is limited information on compounded apixaban formulations for administration via enteral feeding tubes. This study was designed to identify a suitable apixaban suspension formulation that is easy to prepare in a pharmacy setting, is compatible with commonly used feeding tubes, and has a beyond-use date of 7 days. Methods: Apixaban suspensions were prepared from commercially available 5-mg Eliquis tablets. Several vehicles and compounding methods were screened for ease of preparation, dosage accuracy, and tube compatibility...
July 2017: Hospital Pharmacy
https://www.readbyqxmd.com/read/29323421/head-and-neck-cancer-tumor-seeding-at-the-percutaneous-endoscopic-gastrostomy-site
#12
REVIEW
June R Greaves
The National Institutes of Health National Cancer Institute estimates that over 13,000 new cases of head and neck cancer (HNC) will be diagnosed in 2017. Patients with HNC often require enteral nutrition (EN) via gastrostomy tube to provide nutrition support and hydration because of tumor obstruction of the oropharynx and/or cumulative effects of chemoradiation therapy. The percutaneous endoscopic gastrostomy (PEG) tube has become the preferred technique for EN access because placement is considered a minimally invasive procedure...
January 11, 2018: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/29310429/infant-percutaneous-endoscopic-gastrostomy-risks-or-benefits
#13
Francesco Macchini, Andrea Zanini, Giorgio Farris, Anna Morandi, Giulia Brisighelli, Valerio Gentilino, Giorgio Fava, Ernesto Leva
Background/Aims: To present a single center's experience with percutaneous endoscopic gastrostomy (PEG) tube placement in infants. Methods: Clinical records of infants who underwent PEG tube placement between January 2010 and December 2015 were reviewed. All patients underwent an upper gastrointestinal contrast study and an abdominal ultrasonography before the procedure. PEGs were performed with a 6-mm endoscope using the standard pull-through technique. Data regarding gestational age, birth weight, age and weight, days to feeding start, days to full diet, and complications were reviewed...
January 9, 2018: Clinical Endoscopy
https://www.readbyqxmd.com/read/29305611/mechanical-properties-of-arterial-elastin-with-water-loss
#14
Yunjie Wang, Jacob Hahn, Yanhang Zhang
Elastin is a peculiar elastomer in that it requires water to maintain resilience, and its mechanical properties are closely associated with the immediate aqueous environment. The bulk, extra- and intrafibrillar water plays important roles in both elastic and viscoelastic properties of elastin. In this study, a two-stage liquid-vapor method was developed to investigate the effects of water loss on the mechanical properties of porcine aortic elastin. The tissue samples started in a PBS solution at their fully hydrated condition, with a gravimetric water content of 370 ± 36%...
January 5, 2018: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/29299514/percutaneous-gastrostomy-site-metastasis-from-head-and-neck-tumors-a-single-institution-case-series
#15
James S Metkus, David Cognetti, Joseph Curry
Objectives: Head and neck cancer (HNC) patients often require percutaneous gastrostomy (PEG) tube placement due to malnutrition and dysphagia. While beneficial, PEG tube placement can cause a rare but reportable complication of metastasis of the original tumor to the gastrostomy exit site. The objectives of this case series were to present HNC patients at a single institution that developed PEG tube metastases, their subsequent treatment, and review of the literature for similar cases...
December 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/29261208/realization-of-a-stable-monodisperse-water-in-oil-droplet-system-with-micro-scale-and-nano-scale-confinement-for-tandem-microscopy-and-diffusion-nmr-studies
#16
Swomitra Palit, Somayeh Khajehpour Tadavani, Anand Yethiraj
In this work we generate stable and monodisperse water-in-oil emulsions using a co-flowing geometry that produced droplet sizes between 13 μm and 250 μm. The drops survived transfer to NMR tubes and were stable for at least 26 hours, enabling the performance of pulsed-field-gradient NMR experiments in addition to microscopy. The drops sizes achieved as a function of flow rate agree well with a simple model for droplet generation: this yields a precise measure of the interfacial tension. The design of a cell mimetic environment with nano-scale confinement has also been demonstrated with diffusion measurements on macromolecules (PEG and Ficoll70) within droplets that are further structured internally using agarose gel networks...
December 20, 2017: Soft Matter
https://www.readbyqxmd.com/read/29247265/end-of-life-care-pathway-of-head-and-neck-cancer-patients-single-institution-experience
#17
T Heinonen, V Loimu, K Saarilahti, T Saarto, A Mäkitie
BACKGROUND: Studies on palliative care of head and neck cancer (HNC) patients are scarce although the affected patient population is quite large. OBJECTIVE: To evaluate the role of a specialised palliative-care pathway of HNC patients. PATIENTS AND METHODS: Data on all HNC patients who were treated at the Helsinki University Hospital Palliative Care Center during 1 year were retrospectively reviewed. The analysis comprised 60 patients (49 males; mean age 67 years; range 28-88)...
December 15, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29245383/re-characterization-of-i-gymelloxes-i-with-a-re-description-of-i-gymelloxes-terea-i-from-central-america-lepidoptera-hepialidae
#18
John R Grehan, Carlos G C Mielke
The hepialid genus Gymelloxes Viette, 1952 is characterized by, and differs from all other genera, by the male genitalia and a combination of characters. G. terea is redescribed due to the brevity of the original description. The male genitalia of Gymelloxes terea (Schaus, 1892) include two features that are unique within the Hepialidae - a posteriorly angled and digitiform tergal lobe, and two shallow, peg-like processes on the posterior margin of the saccus. The male phallus also exhibits minute sclerotized spicules or spots on the apex of an otherwise membranous tube...
December 12, 2017: Zootaxa
https://www.readbyqxmd.com/read/29218657/comparison-of-laparoscopic-jejunostomy-tube-to-percutaneous-endoscopic-gastrostomy-tube-with-jejunal-extension-long-term-durability-and-nutritional-outcomes
#19
Ivy N Haskins, Andrew T Strong, Mary Baginsky, Gautam Sharma, Matthew Karafa, Jeffrey L Ponsky, John H Rodriguez, Matthew D Kroh
INTRODUCTION: Enteral access through the jejunum is indicated when patients cannot tolerate oral intake or gastric feeding. While multiple approaches for feeding jejunal access exist, few studies have compared the efficacy of these techniques. The purpose of this study was to investigate the long-term durability, re-intervention rates, and nutritional outcomes following percutaneous endoscopic gastrostomy tubes with jejunal extension tubes (PEG-JET) versus laparoscopic jejunostomy tubes (j-tubes)...
December 7, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29186164/a-retrospective-matched-cohort-study-evaluating-the-effects-of-percutaneous-endoscopic-gastrostomy-feeding-tubes-on-nutritional-status-and-survival-in-patients-with-advanced-gastroesophageal-malignancies-undergoing-systemic-anti-cancer-therapy
#20
Scott Mitchell, John P Williams, Harsimrandeep Bhatti, Toufic Kachaamy, Jeffrey Weber, Glen J Weiss
BACKGROUND: Many patients with cancer or other systemic illnesses can experience malnutrition. One way to mitigate malnutrition is by insertion of a percutaneous endoscopic gastrostomy feeding tube (PEG tube). The goal of this retrospective matched cohort study is to evaluate if PEG tube placement improved nutritional status and overall survival (OS) in advanced gastroesophageal (GE) cancer patients who are undergoing anti-neoplastic therapy. METHODS: GE cancer patients who were treated and evaluated by a nutritionist and had at least 2 nutritionist follow-up visits were identified...
2017: PloS One
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