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https://www.readbyqxmd.com/read/28636005/mass-mobility-and-ms-n-measurements-of-single-ions-using-charge-detection-mass-spectrometry
#1
Andrew G Elliott, Conner C Harper, Haw-Wei Lin, Evan R Williams
Charge detection mass spectrometry is used to measure the mass, charge, MS(n) and mobility of an individual ion produced by electrospray ionization of a 8 MDa polyethylene glycol sample. The charge detection mass spectrometer is an electrostatic ion trap that uses cone electrodes and a single tube detector and can detect ions for up to the full trapping time of 4.0 s. The time-domain signal induced on the detector tube by a single multiply charged ion can be complex owing to sequential fragmentation of the original precursor ion as well as increasing oscillation frequencies of the single ion owing to collisions with background gas that reduce the kinetic energy of the ion inside the trap...
June 21, 2017: Analyst
https://www.readbyqxmd.com/read/28631871/efficacy-of-percutaneous-endoscopic-gastro-jejunostomy-peg-j-decompression-therapy-for-patients-with-chronic-intestinal-pseudo-obstruction-cipo
#2
H Ohkubo, A Fuyuki, J Arimoto, T Higurashi, T Nonaka, Y Inoh, H Iida, M Inamori, T Kaneda, A Nakajima
BACKGROUNDS: Chronic intestinal pseudo-obstruction (CIPO) is an intractable rare digestive disease manifesting persistent small bowel distension without any mechanical cause. Intestinal decompression is a key treatment, but conventional method including a trans-nasal small intestinal tube is invasive and painful. Therefore, a less invasive and tolerable new decompression method is urgently desired. We conducted a pilot study and assessed the efficacy and safety of percutaneous endoscopic gastro-jejunostomy (PEG-J) decompression therapy in CIPO patients...
June 20, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28620622/intrahepatic-migration-of-gastrostomy-tube-after-inadvertent-transhepatic-peg-placement
#3
Catarina Atalaia-Martins, Sandra Barbeiro, Pedro Marcos, Inês Gil, Isabel Cotrim
No abstract text is available yet for this article.
2017: ACG Case Reports Journal
https://www.readbyqxmd.com/read/28589712/inhibition-of-angiogenesis-impairs-bone-healing-in-an-in-vivo-murine-rapid-resynostosis-model
#4
Sharon L Hyzy, Illya Kajan, D Scott Wilson, Kelsey A Lawrence, Devon Mason, Joseph K Williams, Rene Olivares-Navarrete, David J Cohen, Zvi Schwartz, Barbara D Boyan
Biologics can improve bone formation, but may diffuse away from sites of therapeutic need. We developed a click-chemistry hydrogel that rapidly polymerizes in situ to control delivery of biologics during post-suturectomy resynostosis in 21-d-old male mice. Here, we used this model to determine the role of angiogenesis in post-suturectomy resynostosis and examine whether controlled release of angiogenesis inhibitors could delay bone regeneration. Hydrogels [DB-co-PEG/poly(TEGDMA)-co-(N3-TEGDMA)] were produced containing anti-angiogenic compounds (anti-VEGFA-antibody or HIF1α-inhibitor topotecan)...
June 7, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28584848/acute-shunt-failure-due-to-perforation-of-ventriculoperitoneal-shunt-tubing-during-percutaneous-gastrostomy
#5
Andrew C Vivas, Michael Wilsey, Joseph K Potthast, Gerald F Tuite
The placement of a percutaneous endoscopic gastrostomy (PEG) in a patient with a pre-existing ventriculoperitoneal shunt is generally regarded as safe. A critical but often overlooked technical consideration is confirmation of the course of the distal shunt tube prior to PEG insertion. We present the case of a 4-month-old male infant with shunted hydrocephalus who experienced shunt malfunction due to perforation of the distal shunt tubing after PEG placement.
2017: ACG Case Reports Journal
https://www.readbyqxmd.com/read/28559079/respiratory-and-swallowing-outcomes-based-on-aneurysm-location-in-360-patients-with-subarachnoid-hemorrhage
#6
Isaac Josh Abecassis, Ryan P Morton, Lynn McGrath, Josiah Hanson, Anna H Xue, Cory M Kelly, Michael R Levitt, Laligam N Sekhar, Louis J Kim
INTRODUCTION: Aneurysmal subarachnoid hemorrhage (aSAH) may result in abnormal respiratory and swallowing function. We analyzed factors that may influence long-term respiratory and swallowing function in aSAH patients, and compared patients with anterior and posterior aneurysm locations. METHODS: We retrospectively reviewed 360 consecutive aSAH patients. We recorded location of the aneurysm and respiratory indices on admission, in-hospital adverse respiratory events and the need for tracheostomy (for respiratory failure) or percutaneous endoscopic gastrostomy (PEG) tube (for prolonged dysphagia)...
May 27, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28531451/new-laparoscopic-assisted-percutaneous-gastrostomy-description-and-comparison-with-others-gastrostomy-types
#7
Pilar Serrano Aguayo, Noelia Gros Herguido, Juana Parejo Campos, Antonio Barranco Moreno, María Del Castillo Tous Romero, José Luis Pereira Cunill, Isaías Alarcón Del Agua, María Socas Macias, Pedro Pablo García Luna, Salvador Morales Conde
INTRODUCTION: Gastrostomy feeding tube insertion has become a common procedure as it enables patients who require long term enteral feeding. Conventional surgical gastrostomies were the only way of gaining enteral access in patients in which it is not possible to pass an endoscope or a nasogastric tube required for endoscopic or radiological gastrostomies, and in patients in which certain anatomical abnormalities contraindicate performing these techniques. As conventional surgical gastrostomies are associated with high morbidity, especially gastric leakage around the tube, percutaneous laparoscopic assisted gastrostomy (PLAG) may be a better way to gain enteral access...
December 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28507748/comparison-of-the-pull-and-introducer-percutaneous-endoscopic-gastrostomy-techniques-in-patients-with-head-and-neck-cancer
#8
Felipe A Retes, Fabio S Kawaguti, Marcelo S de Lima, Bruno da Costa Martins, Ricardo S Uemura, Gustavo A de Paulo, Caterina Mp Pennacchi, Carla Gusmon, Adriana Vs Ribeiro, Elisa R Baba, Sebastian N Geiger, Mauricio P Sorbello, Marco A Kulcsar, Ulysses Ribeiro, Fauze Maluf-Filho
BACKGROUND AND STUDY AIMS: Percutaneous endoscopic gastrostomy (PEG) in head and neck cancer (HNC) patients is associated with higher complication and mortality rates when compared to a general patient population. The pull technique is still the preferred technique worldwide but it has some limitations. The aim of this study is to compare the pull and introducer PEG techniques in patients with HNC. PATIENTS AND METHODS: This study is based on a retrospective analysis of a prospectively collected database of 309 patients with HNC who underwent PEG in the Cancer Institute of São Paulo...
April 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28496536/percutaneous-endoscopic-gastrostomy-in-a-patient-with-continuous-intrathecal-baclofen-infusion-therapy
#9
Ezekiel Wong Toh Yoon, Masuki Kobayashi
Percutaneous endoscopic gastrostomy (PEG) is the method of choice in patients requiring long-term enteral tube feeding. In patients with intrathecal baclofen infusion therapy (IBT) pump implantation, infection via the skin and soft tissue may be an issue of concern. The introducer technique for gastrostomy tube insertion may be useful in reducing the risk of peristomal infection. Although the presence of a PEG tube has been reported as a risk factor for implantation site infection (for newly inserted IBT pumps), whether existing IBT pumps are at risk for infection during or after the placement of a PEG tube is not clear...
April 2017: Gastroenterology Research
https://www.readbyqxmd.com/read/28488039/development-of-antimicrobial-coating-by-later-by-layer-dip-coating-of-chlorhexidine-loaded-micelles
#10
Supreeda Tambunlertchai, Siriwan Srisang, Norased Nasongkla
Layer-by-layer (LbL) dip coating, accompanying with the use of micelle structure, allows hydrophobic molecules to be coated on medical devices' surface via hydrogen bonding interaction. In addition, micelle structure also allows control release of encapsulated compound. In this research, we investigated methods to coat and maximize the amount of chlorhexidine (CHX) on silicone surface through LbL dip coating method utilizing hydrogen bonding interaction between PEG on micelle corona and PAA. The number of coated cycles was varied in the process and 90 coating cycles provided the maximum amount of CHX loaded onto the surface...
June 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28469206/novel-technique-to-manage-recurrent-peg-j-tube-dislodgement-with-full-thickness-endoscopic-suturing
#11
Abhishek Agnihotri, Sindhu Barola, Jamie Flickinger, Mouen A Khashab, Vivek Kumbhari
No abstract text is available yet for this article.
May 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28449220/survival-functional-status-and-eating-ability-after-percutaneous-endoscopic-gastrostomy-tube-placement-for-acute-stroke
#12
Karl Meisel, Robert M Arnold, Irena Stijacic Cenzer, John Boscardin, Alexander K Smith
OBJECTIVES: To determine the long-term survival and independence of individuals with stroke and percutaneous endoscopic gastrostomy (PEG) tube placement. DESIGN: Retrospective cohort study. SETTING: A longitudinal nationally representative community-based sample of older adults. PARTICIPANTS: Individuals with stroke who had a PEG tube placed (N = 174, mean age 79, 51% female, 29% African American). MEASUREMENTS: Functional status before incident stroke was determined based on data from the Health and Retirement Study (HRS), a national longitudinal survey of community-dwelling older adults, from 1993 to 2012...
April 27, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28436481/fusions-of-tumor-derived-endothelial-cells-with-dendritic-cells-induces-antitumor-immunity
#13
Yingying Huang, Qiqi Mao, Jian He, Jing Su, Yi Peng, Wei Liang, Zixi Hu, Sufang Zhou, Xiaoling Lu, Yongxiang Zhao
To explore dendritic cells/tumor-derived endothelial cells (DC/EC) fusion cells are potent stimulators of T cells to impact tumor progression. ECs were isolated from mice hepatoma cell line (H22) Xenograft, and dendritic cells were isolated from bone marrow of BALB/c mice, then the isolated ECs were cultured and detected the endothelial surface expression of CD105 by flow cytometry. The endothelial characteristics of ECs were detected by tube formation assay and Dil-Ac-LDL uptake assay. After the fusion with polyethylene glycol (PEG), we used DCs, ECs, DCs mixed ECs as the control groups, DC/EC fusion cells as the experimental group, Secretion of IFN-α and IFN-γ was evaluated, T lymphocyte proliferation and cytotoxic T lymphocytes (CTL) were detected in vitro...
April 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28436419/nontuberculous-mycobacteria-in-gastrostomy-fed-patients-with-cystic-fibrosis
#14
H Al-Momani, A Perry, R Jones, S Bourke, S Doe, J Perry, A Anderson, T Forrest, I Forrest, M Griffin, M Brodlie, J Pearson, C Ward
Multi-drug resistant Mycobacterium abscessus complex (MABSC) is a form of Nontuberculous mycobacteria (NTM) of special, international concern in Cystic Fibrosis (CF). We hypothesised that gastric juice and percutaneous endoscopic gastrostomy (PEG) feeding devices might yield MABSC isolates. Gastric juice and sputa from sixteen adult PEG fed CF patients and five replaced PEG tubes were studied. Bacterial and fungal isolates were cultured. Mycobacterium were identified by rpoB, sodA and hsp65 gene sequencing and strain typed using variable number tandem repeat...
April 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28434096/benefits-and-risks-of-a-percutaneous-endoscopic-gastrostomy-peg-for-decompression-in-patients-with-malignant-gastrointestinal-obstruction
#15
Anne Dittrich, Barbara Schubert, Michael Kramer, Felicitas Lenz, Karin Kast, Ulrich Schuler, Markus K Schuler
PURPOSE: Gastrointestinal obstruction presents many burdens for patients with end-stage abdominal cancer, such as nausea and vomiting. Few detailed data on the efficacy of a percutaneous endoscopic gastrostomy (PEG) for decompression exists. This retrospective cohort study investigates the quantity of symptom relief realized with PEG and the corresponding complications. METHODS: Chart reviews of 75 patients with malignant gastrointestinal obstruction, who received a PEG for decompression, were performed...
April 22, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28421810/catheter-traction-and-gastric-outlet-obstruction-a-repeated-complication-of-using-a-foley-catheter-for-gastrostomy-tube-replacement
#16
Jorge Fonseca, Gonçalo Nunes, Marta Patita, Rita Barosa, Carla Adriana Santos
BACKGROUND: Percutaneous endoscopic gastrostomy (PEG) is a safe procedure and major morbidity is unusual. However, the number of PEG fed patients is increasing all over the world and complications may become more and more frequent. CASE REPORT: We describe a 73 years old woman with persistent vomit after replacement of the standard PEG tube with a Foley catheter. An upper GI endoscopy showed the catheter pulled into the duodenum causing gastric outlet obstruction...
March 30, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28405323/the-use-of-enteral-access-for-continuous-delivery-of-levodopa-carbidopa-in-patients-with-advanced-parkinson-s-disease
#17
Julian Cheron, Jacques Deviere, Frederic Supiot, Asuncion Ballarin, Pierre Eisendrath, Emmanuel Toussaint, Vincent Huberty, Carmen Musala, Daniel Blero, Arnaud Lemmers, André Van Gossum, Marianna Arvanitakis
BACKGROUND: Continuous delivery to the jejunum of levodopa-carbidopa is a promising therapy in patients with advanced Parkinson's disease, as it reduces motor fluctuation. Percutaneous endoscopic gastrostomy and jejunal tube (PEG-J) placement is a suitable option for this. However, studies focused in PEG-J management are lacking. OBJECTIVES: We report our experience regarding this technique, including technical success, adverse events and outcomes, in patients with advanced Parkinson's disease...
February 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28362572/indicators-for-enteral-nutrition-use-and-prophylactic-percutaneous-endoscopic-gastrostomy-placement-in-patients-with-head-and-neck-cancer-undergoing-chemoradiotherapy
#18
Nina C van der Linden, Annemieke Kok, Marja J Leermakers-Vermeer, Nicole M de Roos, Remco de Bree, Hester van Cruijsen, Chris H J Terhaard
BACKGROUND: Chemoradiotherapy (CRT) is a major risk factor for malnutrition and dehydration in patients with head and neck cancer. Enteral support is often needed, and a percutaneous endoscopic gastrostomy (PEG) is frequently placed. Specific indicators for PEG placement remain unclear. This study retrospectively determined which factors contributed to enteral nutrition (EN) use and PEG placement in a large patient group to gain insight on potential indicators for PEG placement protocol creation...
April 2017: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/28361309/reconstitution-of-a-patterned-neural-tube-from-single-mouse-embryonic-stem-cells
#19
Keisuke Ishihara, Adrian Ranga, Matthias P Lutolf, Elly M Tanaka, Andrea Meinhardt
The recapitulation of tissue development and patterning in three-dimensional (3D) culture is an important dimension of stem cell research. Here, we describe a 3D culture protocol in which single mouse ES cells embedded in Matrigel under neural induction conditions clonally form a lumen containing, oval-shaped epithelial structure within 3 days. By Day 7 an apicobasally polarized neuroepithelium with uniformly dorsal cell identity forms. Treatment with retinoic acid at Day 2 results in posteriorization and self-organization of dorsal-ventral neural tube patterning...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28352884/fountain-streaming-contributes-to-fast-tip-growth-through-regulating-the-gradients-of-turgor-pressure-and-concentration-in-pollen-tubes
#20
ShaoBao Liu, Han Liu, ShangSheng Feng, Min Lin, Feng Xu, Tian Jian Lu
Fountain streaming is a typical microfluidic pattern in plant cells, especially for cells with a high aspect ratio such as pollen tubes. Although it has been found that fountain streaming plays crucial roles in the transport of nutrients and metabolites, the positioning of organelles and the mixing of cytoplasms, its implications for the fast tip growth of pollen tubes remain a mystery. To address this, based on the observations of asiatic lily Lilium Casablanca, we developed physical models for reverse fountain streaming in pollen tubes and solved the hydrodynamics and advection-diffusion dynamics of viscous Stokes flow in the shank and apical region of pollen tubes...
April 19, 2017: Soft Matter
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