keyword
https://read.qxmd.com/read/38460118/rural-urban-disparities-in-the-diagnosis-and-treatment-of-hypertension-and-diabetes-among-aging-indians
#21
JOURNAL ARTICLE
Pooja Rai, Pravin Sahadevan, Abhishek L Mensegere, Thomas G Issac, Graciela Muniz-Terrera, Jonas S Sundarakumar
INTRODUCTION: Hypertension and diabetes are modifiable risk factors for dementia. We aimed to assess rural-urban disparities in the diagnosis and treatment of these conditions among aging Indians. METHODS: Participants (n = 6316) were from two parallel, prospective aging cohorts in rural and urban India. Using self-report and clinical/biochemical assessments, we subdivided participants with diabetes and hypertension into undiagnosed and untreated groups...
March 9, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://read.qxmd.com/read/38451283/whole-grain-intake-in-mid-life-and-healthy-ageing-in-the-danish-diet-cancer-and-health-cohort
#22
JOURNAL ARTICLE
Anne Kirstine Eriksen, Mia Klinten Grand, Cecilie Kyrø, Jan Wohlfahrt, Kim Overvad, Anne Tjønneland, Anja Olsen
PURPOSE: Growing elderly populations worldwide have sparked interest in factors promoting healthy aging. Diet and other lifestyle patterns are key factors for healthy ageing; however, evidence is sparse for specific dietary guidelines that are easily implemented in everyday life. Whole grains constitute specific dietary components with unexplored potential in healthy ageing. METHODS: We applied an illness-death multistate model to assess the association between whole-grain intake and life expectancy, both with and without disease, over a 20-year period...
March 7, 2024: European Journal of Nutrition
https://read.qxmd.com/read/38450380/revised-temperament-and-character-inventory-factors-predict-neuropsychiatric-symptoms-and-aging-related-cognitive-decline-across-25%C3%A2-years
#23
JOURNAL ARTICLE
Lucas Ronat, Michael Rönnlund, Rolf Adolfsson, Alexandru Hanganu, Sara Pudas
INTRODUCTION: Personality traits and neuropsychiatric symptoms such as neuroticism and depression share genetic overlap and have both been identified as risks factors for development of aging-related neurocognitive decline and Alzheimer's disease (AD). This study aimed to examine revised personality factors derived from the Temperament and Character Inventory, previously shown to be associated with psychiatric disorders, as predictors of neuropsychiatric, cognitive, and brain trajectories of participants from a population-based aging study...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38448062/knowledge-attitude-and-practices-of-insulin-therapy-among-patients-with-type-2-diabetes-a-cross-sectional-study
#24
JOURNAL ARTICLE
Ayesha Almheiri, Eman Ali Binjab, Maha Murad Albloushi, Mohamed Taryam Alshamsi, Hamda Hassan Khansaheb, Marwan Zidan, Ahmed Abdul Karim Hassoun
OBJECTIVES: This study aimed to assess the knowledge, attitude and practices of patients with type 2 diabetes on insulin regarding insulin therapy. DESIGN: A cross-sectional study. SETTING: This study was conducted at the Dubai Diabetes Center from 1 December 2018 to 1 March 2020. PARTICIPANTS: Face-to-face interviews were conducted for 350 participants with type 2 diabetes at the Dubai Diabetes Center. Interviews followed the structured format of a questionnaire designed to obtain demographic details and score participants on knowledge, attitude and practices...
March 5, 2024: BMJ Open
https://read.qxmd.com/read/38447106/trends-in-cognitive-function-before-and-after-diabetes-onset-the-china-health-and-retirement-longitudinal-study
#25
JOURNAL ARTICLE
Qingmei Chen, Sijia Zhu, Jing Shang, Qi Fang, Qun Xue, Jianian Hua
BACKGROUND AND OBJECTIVES: Individuals with prevalent diabetes were known to have a higher risk of dementia and lower cognitive function. However, trends of cognitive function before diabetes and in the short term after new-onset diabetes remain unclear. METHODS: This study included participants without baseline diabetes from the China Health and Retirement Longitudinal Study. Cognitive tests were conducted at baseline (wave 1) and at least one time from wave 2 (2013) to wave 4 (2018)...
April 9, 2024: Neurology
https://read.qxmd.com/read/38444404/artificial-intelligence-approaches-for-early-detection-of-neurocognitive-disorders-among-older-adults
#26
JOURNAL ARTICLE
Khalid AlHarkan, Nahid Sultana, Noura Al Mulhim, Assim M AlAbdulKader, Noor Alsafwani, Marwah Barnawi, Khulud Alasqah, Anhar Bazuhair, Zainab Alhalwah, Dina Bokhamseen, Sumayh S Aljameel, Sultan Alamri, Yousef Alqurashi, Kholoud Al Ghamdi
INTRODUCTION: Dementia is one of the major global health issues among the aging population, characterized clinically by a progressive decline in higher cognitive functions. This paper aims to apply various artificial intelligence (AI) approaches to detect patients with mild cognitive impairment (MCI) or dementia accurately. METHODS: Quantitative research was conducted to address the objective of this study using randomly selected 343 Saudi patients. The Chi-square test was conducted to determine the association of the patient's cognitive function with various features, including demographical and medical history...
2024: Frontiers in Computational Neuroscience
https://read.qxmd.com/read/38443972/evaluation-of-the-prevalence-of-cardiometabolic-disorders-diabetes-hypertension-and-hyperlipidemia-diagnosed-undiagnosed-treated-and-treatment-goal-in-the-elderly-bushehr-elderly-health-program-beh
#27
JOURNAL ARTICLE
Mahbube Ebrahimpur, Erfan Mohammadi-Vajari, Yasaman Sharifi, Leila Ghotbi, Masoumeh Sarvari, Aryan Ayati, Baran Hashemi, Zhaleh Shadman, Pouria Khashayar, Afshin Ostovar, Noushin Fahimfar, Gita Shafiee, Elnaz Shahmohamadi, Tahereh Yavari, Iraj Nabipour, Bagher Larijani, Moloud Payab, Farshad Sharifi
As the population ages, the global burden of cardiometabolic disorders will increase. This study aimed to investigate the prevalence of cardiometabolic disorders (diabetes, hypertension, and hyperlipidemia) in elderly and to evaluate the effects of various variables including age, sex, education, marital status, smoking, income, physical activity, dementia and depressed mood on untreated cardiometabolic disorders. This was a cross sectional study conducted in Bushehr Elderly Health Program. A total 2381 participants were included...
March 5, 2024: BMC Endocrine Disorders
https://read.qxmd.com/read/38438772/associations-of-plasma-proteomics-and-age-related-outcomes-with-brain-age-in-a-diverse-cohort
#28
JOURNAL ARTICLE
Ramon Casanova, Keenan A Walker, Jamie N Justice, Andrea Anderson, Michael R Duggan, Jenifer Cordon, Ryan T Barnard, Lingyi Lu, Fang-Chi Hsu, Sanaz Sedaghat, Anna Prizment, Stephen B Kritchevsky, Lynne E Wagenknecht, Timothy M Hughes
Machine learning models are increasingly being used to estimate "brain age" from neuroimaging data. The gap between chronological age and the estimated brain age gap (BAG) is potentially a measure of accelerated and resilient brain aging. Brain age calculated in this fashion has been shown to be associated with mortality, measures of physical function, health, and disease. Here, we estimate the BAG using a voxel-based elastic net regression approach, and then, we investigate its associations with mortality, cognitive status, and measures of health and disease in participants from Atherosclerosis Risk in Communities (ARIC) study who had a brain MRI at visit 5 of the study...
March 4, 2024: GeroScience
https://read.qxmd.com/read/38435221/a-retrospective-study-on-the-outcome-of-coronavirus-disease-2019-covid-19-patients-admitted-to-a-district-general-hospital-and-predictors-of-high-mortality
#29
JOURNAL ARTICLE
Zahid Khan, Gideon Mlawa, Saiful Islam, Suhier Elshowaya, Mohammad Saleem
BACKGROUND: The clinical features and severity of coronavirus disease 2019 (COVID-19) vary between patients and countries. Patients with certain conditions are predisposed to poor outcomes compared with those without medical conditions, such as diabetes, dementia, and hypertension (HTN). METHODS: The aim of this retrospective study was to assess factors associated with higher mortality in patients with COVID-19 infections and to identify the reason for hospital admission in these patients...
February 2024: Curēus
https://read.qxmd.com/read/38432248/early-life-cumulative-exposure-to-excess-bodyweight-and-midlife-cognitive-function-longitudinal-analysis-in-three-british-birth-cohorts
#30
JOURNAL ARTICLE
Scott T Chiesa, Tom Norris, Victoria Garfield, Marcus Richards, Alun D Hughes
BACKGROUND: Excess bodyweight (BMI >25 kg/m2 ) in midlife (age 40-65 years) has been linked to future cognitive decline and an increased risk of dementia. Whether chronic exposure to excess bodyweight in the early decades of life (<40 years) is associated with compromised cognitive function by midlife, however, remains unclear. This study therefore aimed to test potential bidirectional direct and indirect pathways linking cumulative exposure to excess bodyweight and cognitive function in the early decades of life...
March 2024: The Lancet. Healthy longevity
https://read.qxmd.com/read/38426291/the-microbiota-gut-brain-axis%C3%A2-in-huntington-s-disease-pathogenic-mechanisms-and-therapeutic-targets
#31
REVIEW
Millicent N Ekwudo, Carolina Gubert, Anthony J Hannan
Huntington's disease (HD) is a currently incurable neurogenerative disorder and is typically characterized by progressive movement disorder (including chorea), cognitive deficits (culminating in dementia), psychiatric abnormalities (the most common of which is depression), and peripheral symptoms (including gastrointestinal dysfunction). There are currently no approved disease-modifying therapies available for HD, with death usually occurring approximately 10-25 years after onset, but some therapies hold promising potential...
March 1, 2024: FEBS Journal
https://read.qxmd.com/read/38425134/investigating-the-impact-of-hypertension-with-and-without-diabetes-on-alzheimer-s-disease-risk-a-clinico-pathological-study
#32
JOURNAL ARTICLE
Myuri Ruthirakuhan, Walter Swardfager, Lisa Xiong, Bradley J MacIntosh, Jennifer S Rabin, Krista L Lanctôt, Julie Ottoy, Joel Ramirez, Julia Keith, Sandra E Black
INTRODUCTION: Hypertension and diabetes are common cardiovascular risk factors that increase Alzheimer's disease (AD) risk. However, it is unclear whether AD risk differs in hypertensive individuals with and without diabetes. METHODS: Cognitively normal individuals (N = 11,074) from the National Alzheimer's Coordinating Center (NACC) were categorized as having (1) hypertension with diabetes (HTN+/DM+), (2) hypertension without diabetes (HTN+/DM-), or (3) neither (HTN-/DM-)...
February 29, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://read.qxmd.com/read/38425117/incretin-therapy-and-insulin-signaling-therapeutic-targets-for-diabetes-and-associated-dementia
#33
JOURNAL ARTICLE
Deepika Joshi
Dementia is the primary cause of disability and dependence among the elderly population worldwide. The population living with dementia is anticipated to double in the next 17 years. Recent studies show the fact that compared to people without diabetes, people with Type 2 Diabetes (T2D) have about a 60% increased chance of developing dementia. In addition to cholinergic function being downregulated, improper insulin signalling also has a negative impact on synaptic plasticity and neuronal survival. Type 2 diabetes and dementia share various similar pathophysiological components...
February 29, 2024: Current Diabetes Reviews
https://read.qxmd.com/read/38424123/glypican-4-serum-levels-are-associated-with-cognitive-dysfunction-and-vascular-risk-factors-in-parkinson-s-disease
#34
JOURNAL ARTICLE
Lars Tatenhorst, Fabian Maass, Hannah Paul, Vivian Dambeck, Mathias Bähr, Rosanna Dono, Paul Lingor
Glypicans are biomarkers for various pathologies, including cardiovascular disease, cancer and diabetes. Increasing evidence suggests that glypicans also play a role in the context of neurodegenerative disorders. Initially described as supporting functionality of synapses via glutamate receptors during CNS development, Glypican 4 (GPC-4) also plays a role in the context of dementia via tau hyperphosphorylation in Alzheimer's disease, which is also a co-pathology in Parkinson's disease dementia. However, clinical evidence of circulating GPC-4 in Parkinson's disease (PD) is missing so far...
February 29, 2024: Scientific Reports
https://read.qxmd.com/read/38423195/the-association-of-glucose-metabolism-measures-and-diabetes-status-with-alzheimer-s-disease-biomarkers-of-amyloid-and-tau-a-systematic-review-and-meta-analysis
#35
REVIEW
Veerle van Gils, Marianna Rizzo, Jade Côte, Wolfgang Viechtbauer, Giuseppe Fanelli, Jordi Salas-Salvadó, Theresa Wimberley, Mònica Bulló, Fernando Fernandez-Aranda, Søren Dalsgaard, Pieter Jelle Visser, Willemijn J Jansen, Stephanie J B Vos
Conflicting evidence exists on the relationship between diabetes mellitus (DM) and Alzheimer's disease (AD) biomarkers. Therefore, we conducted a random-effects meta-analysis to evaluate the correlation of glucose metabolism measures (glycated haemoglobin, fasting blood glucose, insulin resistance indices) and DM status with AD biomarkers of amyloid-β and tau measured by positron emission tomography or cerebrospinal fluid. We selected 37 studies from PubMed and Embase, including 11,694 individuals. More impaired glucose metabolism and DM status were associated with higher tau biomarkers (r=0...
February 27, 2024: Neuroscience and Biobehavioral Reviews
https://read.qxmd.com/read/38417711/hepatopancreatic-metabolic-disorders-and-their-implications-in-the-development-of-alzheimer-s-disease-and-vascular-dementia
#36
REVIEW
Francisco Irochima Pinheiro, Irami Araújo-Filho, Amália Cinthia Meneses do Rego, Eduardo Pereira de Azevedo, Ricardo Ney Cobucci, Fausto Pierdona Guzen
Dementia has been faced with significant public health challenges and economic burdens that urges the need to develop safe and effective interventions. In recent years, an increasing number of studies have focused on the relationship between dementia and liver and pancreatic metabolic disorders that result in diseases such as diabetes, obesity, hypertension and dyslipidemia. Previous reports have shown that there is a plausible correlation between pathologies caused by hepatopancreatic dysfunctions and dementia...
February 26, 2024: Ageing Research Reviews
https://read.qxmd.com/read/38416540/features-of-the-physical-and-social-neighborhood-environment-and-neighborhood-level-alzheimer-s-disease-and-related-dementia-in-south-carolina
#37
JOURNAL ARTICLE
Dana M Alhasan, Gary Larson, Matthew C Lohman, Bo Cai, Frankie B LaPorte, Maggi C Miller, W Braxton Jackson, Nathaniel S MacNell, Jana A Hirsch, Chandra L Jackson
BACKGROUND: Studies are increasingly examining the relationship between the neighborhood environment and cognitive decline; yet, few have investigated associations between multiple neighborhood features and Alzheimer's disease and related dementias (ADRD). OBJECTIVE: We investigated the relationship between neighborhood features and ADRD cumulative incidence from 2010 to 2014 in the South Carolina Alzheimer's Disease Registry (SCADR). METHODS: Diagnosed ADRD cases <mml:math xmlns:mml="https://www...
February 2024: Environmental Health Perspectives
https://read.qxmd.com/read/38416181/-prevention-of-dementia
#38
JOURNAL ARTICLE
Walter M Schippinger, Gerald Pichler
With increasing life expectancy, the prevalence of dementia is increasing worldwide. Dementia is among the greatest challenges for healthcare and social systems of the future. Approximately 40% of newly diagnosed cases of dementia are associated with risk factors that can potentially be influenced by preventive measures. Based on the evidence from longitudinal studies, systematic reviews and meta-analyses, the Lancet commission on dementia prevention, intervention and care has defined 12 risk factors that are associated with an increased risk for dementia: low level of education, hearing impairment, traumatic brain injury, arterial hypertension, diabetes mellitus, smoking, excessive alcohol consumption, depression, obesity, social isolation, and air pollution...
February 28, 2024: Der Nervenarzt
https://read.qxmd.com/read/38405191/risk-factors-for-urinary-tract-infection-in-geriatric-hip-fracture-patients-a-systematic-review-and-meta-analysis
#39
Wei Wang, Wei Yao, Wanyun Tang, Yuhao Li, Hongbo Sun, Wenbo Ding
BACKGROUND: Urinary tract infection (UTI) is a prevalent and consequential complication in hip fracture patients, leading to significant disability and heightened healthcare expenditures. Consequently, there is a critical need for a comprehensive systematic review to identify risk factors and establish early and effective preventive measures. METHODS: A comprehensive search was performed across the PubMed, Cochrane, Embase, Web of Science, and Scopus databases (up to August 31, 2023)...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38404945/impact-of-adverse-pregnancy-outcomes-on-brain-vascular-health-and-cognition
#40
JOURNAL ARTICLE
Katrin Wolfova, Eliza C Miller
A State of the Art lecture titled "Impact of Adverse Pregnancy Outcomes on Brain Vascular Health and Cognition" was presented at the International Society on Thrombosis and Haemostasis Congress in 2023. Adverse pregnancy outcomes, encompassing conditions such as gestational hypertension, eclampsia, preeclampsia, preterm birth, fetal growth restriction, stillbirth, and gestational diabetes, may form part of an underrecognized pathway from early adulthood reproductive health factors to later-life vascular cognitive impairment and dementia in women...
January 2024: Research and Practice in Thrombosis and Haemostasis
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