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https://www.readbyqxmd.com/read/29547343/three-year-results-of-a-medicare-advantage-cancer-management-program
#1
J Russell Hoverman, Marcus A Neubauer, Melissa Jameson, Jad E Hayes, Kathryn J Eagye, Mitra Abdullahpour, Wendy J Haydon, Maria Sipala, Amy Supraner, Michael A Kolodziej, Diana K Verrilli
PURPOSE: Reform of cancer care delivery seeks to control costs while improving quality. Texas Oncology collaborated with Aetna to conduct a payer-sponsored program that used evidence-based treatment pathways, a disease management call center, and an introduction to advance care planning to improve patient care and reduce total costs. METHODS: From June 1, 2013, to May 31, 2016, 746 Medicare Advantage patients with nine common cancer diagnoses were enrolled. Patients electing for patient support services were telephoned by oncology nurses who assessed symptoms and quality of life and introduced advance care planning...
March 16, 2018: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29514279/an-inventory-of-supranational-antimicrobial-resistance-surveillance-networks-involving-low-and-middle-income-countries-since-2000
#2
Elizabeth A Ashley, Judith Recht, Arlene Chua, David Dance, Mehul Dhorda, Nigel V Thomas, Nisha Ranganathan, Paul Turner, Philippe J Guerin, Nicholas J White, Nicholas P Day
Low- and middle-income countries (LMICs) shoulder the bulk of the global burden of infectious diseases and drug resistance. We searched for supranational networks performing antimicrobial resistance (AMR) surveillance in LMICs and assessed their organization, methodology, impacts and challenges. Since 2000, 72 supranational networks for AMR surveillance in bacteria, fungi, HIV, TB and malaria have been created that have involved LMICs, of which 34 are ongoing. The median (range) duration of the networks was 6 years (1-70) and the number of LMICs included was 8 (1-67)...
March 5, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29490651/fiscal-rules-powerful-levers-for-controlling-the-health-budget-evidence-from-32-oecd-countries
#3
Herman Christiaan Schakel, Erilia Hao Wu, Patrick Jeurissen
BACKGROUND: Publicly funded healthcare forms an intricate part of government spending in most Organisation for Economic Co-operation and Development (OECD) countries, because of its reliance on entitlements and dedicated revenue streams. The impact of budgetary rules and procedures on publicly funded health care might thus be different from other spending categories. In this study we focus on the potential of fiscal rules to contain these costs and their design features. METHODS: We assess the relationship between fiscal rules and the level of public health care expenditure of 32 (OECD) countries between 1985 and 2014...
March 1, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29476937/biosimilar-switching-and-related-medical-liability
#4
Paolo Rocco, Sonia Selletti, Paola Minghetti
Unlike generics, biosimilars are similar, but not equivalent, to the reference biological medicinal product. Therefore, if a patient experiences an adverse event, or a loss of efficacy, when transitioned to a biosimilar, the distribution of medical liability will be different from the case of both the originator and generics. Moreover, the case of naïve patients is different from that of non-naïve patients. In the case of naïve patients, physicians make their choice from a range of medicinal products that pose the same risk, since it is not possible to know with any certainty the patients' response to each therapeutic option until they have taken the drug...
February 17, 2018: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/29392897/long-and-short-term-outcomes-in-renal-allografts-with-deceased-donors-a-large-recipient-and-donor-genome-wide-association-study
#5
Maria P Hernandez-Fuentes, Christopher Franklin, Irene Rebollo-Mesa, Jennifer Mollon, Florence Delaney, Esperanza Perucha, Caragh Stapleton, Richard Borrows, Catherine Byrne, Gianpiero Cavalleri, Brendan Clarke, Menna Clatworthy, John Feehally, Susan Fuggle, Sarah A Gagliano, Sian Griffin, Abdul Hammad, Robert Higgins, Alan Jardine, Mary Keogan, Timothy Leach, Iain MacPhee, Patrick B Mark, James Marsh, Peter Maxwell, William McKane, Adam McLean, Charles Newstead, Titus Augustine, Paul Phelan, Steve Powis, Peter Rowe, Neil Sheerin, Ellen Solomon, Henry Stephens, Raj Thuraisingham, Richard Trembath, Peter Topham, Robert Vaughan, Steven H Sacks, Peter Conlon, Gerhard Opelz, Nicole Soranzo, Michael E Weale, Graham M Lord
Improvements in immunosuppression have modified short-term survival of deceased-donor allografts, but not their rate of long-term failure. Mismatches between donor and recipient HLA play an important role in the acute and chronic allogeneic immune response against the graft. Perfect matching at clinically relevant HLA loci does not obviate the need for immunosuppression, suggesting that additional genetic variation plays a critical role in both short- and long-term graft outcomes. By combining patient data and samples from supranational cohorts across the United Kingdom and European Union, we performed the first large-scale genome-wide association study analyzing both donor and recipient DNA in 2094 complete renal transplant-pairs with replication in 5866 complete pairs...
February 1, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29346070/key-pharmacovigilance-stakeholders-experiences-of-direct-patient-reporting-of-adverse-drug-reactions-and-their-prospects-of-future-development-in-the-european-union
#6
P Inácio, A Cavaco, E Allan, M Airaksinen
OBJECTIVES: In the European Union (EU), legislation allows patients to directly report adverse drug reactions (ADRs) to competent authorities. Five years after its implementation, patient reporting is not equal in all countries. This study aimed to explore key stakeholders' perceptions of patient reporting in four EU countries. STUDY DESIGN: Qualitative study design. METHODS: Twelve representatives from national pharmacovigilance centres and/or authorities as well as national pharmaceutical industry bodies in four EU countries participated in the study...
February 2018: Public Health
https://www.readbyqxmd.com/read/29310751/multi-clonal-evolution-of-multi-drug-resistant-extensively-drug-resistant-mycobacterium-tuberculosis-in-a-high-prevalence-setting-of-papua-new-guinea-for-over-three-decades
#7
Arnold Bainomugisa, Evelyn Lavu, Stenard Hiashiri, Suman Majumdar, Alice Honjepari, Rendi Moke, Paison Dakulala, Grant A Hill-Cawthorne, Sushil Pandey, Ben J Marais, Chris Coulter, Lachlan Coin
An outbreak of multi-drug resistant (MDR) tuberculosis (TB) has been reported on Daru Island, Papua New Guinea. Mycobacterium tuberculosis strains driving this outbreak and the temporal accrual of drug resistance mutations have not been described. Whole genome sequencing of 100 of 165 clinical isolates referred from Daru General Hospital to the Supranational reference laboratory, Brisbane, during 2012-2015 revealed that 95 belonged to a single modern Beijing sub-lineage strain. Molecular dating suggested acquisition of streptomycin and isoniazid resistance in the 1960s, with potentially enhanced virulence mediated by an mycP1 mutation...
January 4, 2018: Microbial Genomics
https://www.readbyqxmd.com/read/29247181/culture-and-next-generation-sequencing-based-drug-susceptibility-testing-unveil-high-levels-of-drug-resistant-tb-in-djibouti-results-from-the-first-national-survey
#8
Elisa Tagliani, Mohamed Osman Hassan, Yacine Waberi, Maria Rosaria De Filippo, Dennis Falzon, Anna Dean, Matteo Zignol, Philip Supply, Mohamed Ali Abdoulkader, Hawa Hassangue, Daniela Maria Cirillo
Djibouti is a small country in the Horn of Africa with a high TB incidence (378/100,000 in 2015). Multidrug-resistant TB (MDR-TB) and resistance to second-line agents have been previously identified in the country but the extent of the problem has yet to be quantified. A national survey was conducted to estimate the proportion of MDR-TB among a representative sample of TB patients. Sputum was tested using XpertMTB/RIF and samples positive for MTB and resistant to rifampicin underwent first line phenotypic susceptibility testing...
December 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29239563/a-geographical-information-system-for-the-management-of-the-aquaculture-data-in-the-adriatic-sea-the-strengthening-of-centres-for-aquaculture-production-and-safety-surveillance-in-the-adriatic-countries-experience-present-capabilities-tools-and-functions
#9
Susanna Tora, Silvio Sacchini, Eddy Listeš, Tanja Bogdanović, Alessio Di Lorenzo, Muhamed Smajlović, Ahmed Smajlović, Jelena V Filipović, Vildana Tahirović, Danijela Šuković, Bojan Beljkas, Ardian Xinxo, Renis Maçi, Patrizia Colangeli, Federica Di Giacinto, Annamaria Conte
The European Commission (EC) regulation no. 854/2004 requires a systematic monitoring of chemical and microbiological contaminants in live bivalve molluscs, live echinoderms, live tunicates and live marine gastropods for human consumption through surveillance plans to be implemented in all European Union (EU) countries.A consortium of five Adriatic countries was set up in the framework of the Instrument of Pre-accession Assistance Adriatic Cross-border Cooperation Programme (IPA Adriatic CBC) 2007- 2013 with the aim of collecting data and distribute information on harvesting and production in mollusc areas...
November 8, 2017: Geospatial Health
https://www.readbyqxmd.com/read/29164293/evaluating-partnerships-to-enhance-disaster-risk-management-using-multi-criteria-analysis-an-application-at-the-pan-european-level
#10
REVIEW
Stefan Hochrainer-Stigler, Anna Lorant
Disaster risk is increasingly recognized as a major development challenge. Recent calls emphasize the need to proactively engage in disaster risk reduction, as well as to establish new partnerships between private and public sector entities in order to decrease current and future risks. Very often such potential partnerships have to meet different objectives reflecting on the priorities of stakeholders involved. Consequently, potential partnerships need to be assessed on multiple criteria to determine weakest links and greatest threats in collaboration...
January 2018: Environmental Management
https://www.readbyqxmd.com/read/29132760/hepatitis-c-in-sub-saharan-africa-the-current-status-and-recommendations-for-achieving-elimination-by-2030
#11
REVIEW
Mark W Sonderup, Mary Afihene, Reidwaan Ally, Betty Apica, Yaw Awuku, Lina Cunha, Geoffrey Dusheiko, Neliswa Gogela, Marie-Jeanne Lohouès-Kouacou, Phillip Lam, Olufunmilayo Lesi, Papa Saliou Mbaye, Emmanuel Musabeyezu, Betty Musau, Olesegun Ojo, John Rwegasha, Barbara Scholz, Abate B Shewaye, Christian Tzeuton, Chris Kassianides, C Wendy Spearman
In 2016, WHO adopted a strategy for the elimination of viral hepatitis by 2030. Africa, and more specifically, sub-Saharan Africa, carries a substantial portion of the global burden of viral hepatitis, especially chronic hepatitis B and hepatitis C virus infections. The task that lies ahead for sub-Saharan Africa to achieve elimination is substantial, but not insurmountable. Major developments in the management of hepatitis C have put elimination within reach, but several difficulties will need to be navigated on the path to elimination...
December 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29132759/hepatitis-b-in-sub-saharan-africa-strategies-to-achieve-the-2030-elimination-targets
#12
REVIEW
C Wendy Spearman, Mary Afihene, Reidwaan Ally, Betty Apica, Yaw Awuku, Lina Cunha, Geoffrey Dusheiko, Neliswa Gogela, Chris Kassianides, Michael Kew, Philip Lam, Olufunmilayo Lesi, Marie-Jeanne Lohouès-Kouacou, Papa Saliou Mbaye, Emmanuel Musabeyezu, Betty Musau, Olusegun Ojo, John Rwegasha, Barbara Scholz, Abate B Shewaye, Christian Tzeuton, Mark W Sonderup
The WHO global health sector strategy on viral hepatitis, created in May, 2016, aims to achieve a 90% reduction in new cases of chronic hepatitis B and C and a 65% reduction in mortality due to hepatitis B and C by 2030. Hepatitis B virus (HBV) is endemic in sub-Saharan Africa, and despite the introduction of universal hepatitis B vaccination and effective antiviral therapy, the estimated overall seroprevalence of hepatitis B surface antigen remains high at 6·1% (95% uncertainty interval 4·6-8·5). In this Series paper, we have reviewed the literature to examine the epidemiology, burden of liver disease, and elimination strategies of hepatitis B in sub-Saharan Africa...
December 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29084131/workplace-health-promotion-programs-for-older-workers-in-italy
#13
Nicola Magnavita, Ilaria Capitanelli, Sergio Garbarino, Daniele Ignazio La Milia, Umberto Moscato, Enrico Pira, Andrea Poscia, Walter Ricciardi
BACKGROUND: Italy is the European country with the highest number of citizens over the age of sixty. In recent years, the unsustainability of the social security system has forced the Italian government to raise the retirement age and reduce the chances of early exit, thus sharply increasing the age of the workforce. Consequently, a significant proportion of older workers are currently obliged to do jobs that were designed for young people. Systematic health promotion intervention for older workers is therefore essential...
October 27, 2017: La Medicina del Lavoro
https://www.readbyqxmd.com/read/29074766/big-data-and-the-industrialization-of-neuroscience-a-safe-roadmap-for-understanding-the-brain
#14
REVIEW
Yves Frégnac
New technologies in neuroscience generate reams of data at an exponentially increasing rate, spurring the design of very-large-scale data-mining initiatives. Several supranational ventures are contemplating the possibility of achieving, within the next decade(s), full simulation of the human brain.
October 27, 2017: Science
https://www.readbyqxmd.com/read/28969600/evaluation-of-mycobacterium-tuberculosis-viability-in-omnigene-sputum-reagent-upon-multi-day-transport-at-ambient-temperature
#15
Elisa Tagliani, Riccardo Alagna, Silva Tafaj, Hasan Hafizi, Daniela Maria Cirillo
BACKGROUND: Maintaining the quality of clinical specimens for tuberculosis (TB) testing is a major challenge in many high TB burden-limited resources countries. Sample referral systems in low and middle income countries are often weak and the maintenance of the cold-chain challenging and very costly for TB programs. The development of transport media allowing the preservation of samples without refrigeration is critical for increasing access to TB diagnostic services and for reducing the costs related to testing...
October 2, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28932574/lung-allocation
#16
REVIEW
Jens Gottlieb
Shortage of donor lungs in most western countries and broadening of indications for lung transplantation (LTx) has led increased waiting list mortality in the past. Usually donor lungs and recipients are matched by size as measured by total lung capacity and blood type in first order. In some countries regional allocation comes first, in other countries a national wait list exists and some nations are organized in supranational allocation systems. Organ distribution should respect the ethical principles of equity, justice, beneficence and utility...
August 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28792570/-the-global-model-of-public-mental-health-and-recovery-mentors
#17
Jean-François Pelletier, Émilie Auclair
Objectives The aim of this paper is to revisit the Global Model of Public Mental Health (GMPMH) in light of the 4th Civic Forum. Recovery mentors of the University of Recovery chaired this public event, which was held in East-end Montreal, Canada, in 2016. The University of Recovery is a concept of co-learning among its members.Methods Being able to refer to international conventions and human rights standards is a key component of a genuine global approach that is supportive of individuals and communities in their quest for recovery and full citizenship...
December 0: Santé Mentale Au Québec
https://www.readbyqxmd.com/read/28712666/molecular-surveillance-of-measles-and-rubella-in-the-who-european-region-new-challenges-in-the-elimination-phase
#18
REVIEW
S Santibanez, J M Hübschen, M C Ben Mamou, M Muscat, K E Brown, R Myers, O Donoso Mantke, H Zeichhardt, D Brockmann, S V Shulga, C P Muller, P M O'Connor, M N Mulders, A Mankertz
BACKGROUND: The WHO European Region (EUR) has adopted the goal of eliminating measles and rubella but individual countries perform differently in achieving this goal. Measles virus spread across the EUR by mobile groups has recently led to large outbreaks in the insufficiently vaccinated resident population. As an instrument for monitoring the elimination process and verifying the interruption of endemic virus transmission, molecular surveillance has to provide valid and representative data...
August 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28571023/is-the-fight-against-doping-in-sport-a-legal-minefield-like-any-other
#19
Ulrich Haas
In the fight against doping, creating a level playing field across all sports is very challenging from a legal perspective. A harmonized approach presupposes first and foremost a supreme regulatory authority on a global level. This task cannot be attributed to the public sector, because there is no supranational authority of public international law capable of dealing with it. Thus, responsibility has to be assumed by a private law entity. This in turn requires complicated contractual agreements by which duties and responsibilities are transferred from the individual to the national level and from there to the top of the pyramid...
2017: Medicine and Sport Science
https://www.readbyqxmd.com/read/28558425/production-and-consumption-based-water-dynamics-a-longitudinal-analysis-for-the-eu27
#20
Ana Serrano, Javier Valbuena
This paper investigates the relationship between economic development and water pressures using a global Multiregional Input-Output model (MRIO) dataset that takes into account the increasingly connected global supply chains underlying the economic systems. In particular, we analyse differences in water indicator outcomes by income level among European Union countries (EU27) from 1995 to 2008, focusing specifically on production and consumption-based water metrics for the member states. We use panel fixed effects regressions to study the dynamics of adjustment of water resources alongside controlling for individual country heterogeneity...
December 1, 2017: Science of the Total Environment
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