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https://www.readbyqxmd.com/read/29351033/closing-the-loop-on-centralization-of-cleft-care-in-the-united-kingdom
#1
Andrew R Ness, Andrew R Wills, Andrea Waylen, Jackie Smallridge, Amanda J Hall, Debbie Sell, Jonathan R Sandy
OBJECTIVE: We highlight a major study that investigated the impact of reconfigured cleft care in the United Kingdom some 15 years after centralization. We argue that centralization as an intervention has a major impact on outcomes. SETTING: Audit clinics held in Cleft Centers in the United Kingdom. PATIENTS, PARTICIPANTS: Five-year-olds born between April 1, 2005, and March 31, 2007, with nonsyndromic unilateral cleft lip and palate. INTERVENTIONS: Centralization of cleft care...
February 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29350448/clinical-and-genetic-associations-for-carboplatin-related-ototoxicity-in-children-treated-for-retinoblastoma-a-retrospective-noncomparative-single-institute-experience
#2
Sameh E Soliman, Crystal N D'Silva, Helen Dimaras, Irakli Dzneladze, Helen Chan, Brenda L Gallie
BACKGROUND: Children with retinoblastoma treated with carboplatin chemotherapy risk moderate to severe, irreversible hearing loss. Based on published evidence, we hypothesized that ototoxicity risk is associated with clinical parameters and variants in candidate genes in drug metabolism pathways (methyltransferases [thiopurine S-methyltransferase, TPMT] and [catechol-O-methyltransferase, COMT], and drug transporter ABCC3). PROCEDURE: We retrospectively reviewed clinical records of patients with retinoblastoma treated with carboplatin chemotherapy regarding age (at diagnosis and chemotherapy initiation), chemotherapy sessions (cycles number, drug doses, and cumulative carboplatin dose), and hearing loss (defined as ototoxicity ≥grade 2 by at least one classification system)...
January 19, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29349595/the-development-of-a-nano-based-approach-to-alleviate-cisplatin-induced-ototoxicity
#3
Mohammad N Kayyali, Andrew J Ramsey, Elizabeth M Higbee-Dempsey, Lesan Yan, Bert W O'Malley, Andrew Tsourkas, Daqing Li
Cisplatin-induced hearing loss is experienced by a high percentage of patients with squamous cell carcinoma undergoing cisplatin chemotherapy. A novel nano-construct capable of sequestering extracellular cisplatin was developed to combat this problem. The nano-construct consisted of superparamagnetic iron oxide nanoparticles (SPIONs) entrapped within polymeric micelles, which were formed from a glutathione diethyl ester-conjugated amphiphilic diblock copolymer. The glutathione-micelles were analyzed at the cellular level and in an organotypic study for safety evaluation...
January 18, 2018: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/29348989/signs-and-symptoms-of-acoustic-neuroma-at-initial-presentation-an-exploratory-analysis
#4
Robert W Foley, Shahram Shirazi, Robert M Maweni, Kay Walsh, Rory McConn Walsh, Mohsen Javadpour, Daniel Rawluk
Introduction The objective of this study was to describe the most common clinical features associated with an acoustic neuroma diagnosis and to identify those features associated with larger tumour size at initial diagnosis. Methods The clinical information of 945 consecutive patients diagnosed with acoustic neuroma at a single centre between 1992 and 2015 was analysed. Clinical features were examined and the relationship between these features and tumour size (>2.5 cm) was analysed using descriptive statistics and logistic regression analysis...
November 15, 2017: Curēus
https://www.readbyqxmd.com/read/29348376/-benign-outcome-of-cochlear-implantation-in-a-patient-with-superficial-siderosis
#5
Kei Sato, Takekazu Ohi, Taisaku Shozaki, Shin Kariya
We report the case of a 38-year-old man with gait disorder and hearing loss. The patient had developed gait disorder due to a cervical meningioma since 4 year-old disappeared for 15 years after the surgical removal of the meningioma. However, at the age of 21 year-old, the gait disorder reappeared and worsened progressively. Sensorineural hearing loss (SNHL) and epileptic seizures developed during the disease course, and he was diagnosed with superficial siderosis (SS). When he was 37 years old, he experienced sudden-onset of right-side hearing impairment and was considered a candidate for cochlear implantation (CI) at the otorhinolaryngology clinic of the nearby University Hospital...
January 2018: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/29348197/tackling-hearing-loss-to-improve-the-care-of-older-adults
#6
Jan Blustein, Barbara E Weinstein, Joshua Chodosh
No abstract text is available yet for this article.
January 18, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29348084/molecular-characterization-of-autosomal-recessive-non-syndromic-hearing-loss-in-selected-families-from-district-mardan-pakistan
#7
Shahid Hussain, Jabar Zaman Khattak, Mohammad Ismail, Qaisar Mansoor, Mohammad Haroon Khan
Deafness is the most common sensory disorder, which affects 1/1000 neonates globally. Genetic factors are major contributors for hearing impairment. This study was conducted to explore the linkage of DFNB loci and their mutations with NSHL in selected Pakistani families. We included 10 families with history of deafness from district Mardan, Pakistan. Blood sample (5ml) along with personal and clinical information was collected from the available family members including both diseased and un-affected individuals...
January 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29347892/pilot-study-on-the-use-of-data-mining-to-identify-cochlear-implant-candidates
#8
Jedidiah J Grisel, Erin Schafer, Anne Lam, Terry Griffin
OBJECTIVES: The goal of this pilot study was to determine the clinical utility of data-mining software that screens for cochlear implant (CI) candidacy. METHODS: The Auditory Implant Initiative developed a software module that screens for CI candidates via integration with a software system (Noah 4) that serves as a depository for hearing test data. To identify candidates, patient audiograms from one practice were exported into the screening module. Candidates were tracked to determine if any eventually underwent implantation...
January 19, 2018: Cochlear Implants International
https://www.readbyqxmd.com/read/29347860/alteration-of-auditory-function-in-type-2-diabetic-and-pre-diabetic-patients
#9
Jin Li, Yi Zhang, Xinxing Fu, Jingtao Bi, Yanhong Li, Bo Liu, Luo Zhang
BACKGROUND: The association between type 2 diabetes mellitus (T2DM) and hearing loss has not been fully investigated and there is little information on the effects of pre-diabetes on alterations in auditory function in Chinese subjects. METHODS: The study recruited 51 patients with T2DM, 55 patients with pre-diabetes and 43 control subjects. Auditory function was assessed by pure tone audiometry (PTA) tests and distortion product of otoacoustic emissions (DPOAEs)...
January 18, 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29345223/case-report-neurobrucellosis-with-plastered-spinal-arachnoiditis-a-magnetic-resonance-imaging-based-report
#10
Saraswati Nashi, Veeramani Preethish-Kumar, Sayani Maji, Nagarathna Chandrashekar, Kiran Polavarapu, Chetan Kashinkunti, Kajari Bhattacharya, Jitender Saini, Atchayaram Nalini
Diffuse spinal arachnoiditis in neurobrucellosis is a rare manifestation. We report a boy aged 17, presenting with hearing impairment and recurrent vomiting for 18 months, weight loss for 12 months, dysphagia, dysarthria, hypophonia for 6 months, and gait unsteadiness for 5 months. He had bilateral 5th (motor) to 12th cranial nerve palsy, wasting and weakness of limbs, fasciculations, absent tendon reflexes, and positive Babinski's sign. Cerebrospinal fluid (CSF) showed raised protein and pleocytosis. Magnetic resonance imaging (MRI) showed extensive enhancing exudates in cisterns and post-contrast enhancement of bilateral 5th, 6th, 7th, and 8th nerves...
January 15, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29343804/compound-heterozygous-spata5-variants-in-four-families-and-functional-studies-of-spata5-deficiency
#11
Sanna Puusepp, Reka Kovacs-Nagy, Bader Alhaddad, Matthias Braunisch, Georg F Hoffmann, Urania Kotzaeridou, Lucia Lichvarova, Mailis Liiv, Christine Makowski, Merle Mandel, Thomas Meitinger, Sander Pajusalu, Richard J Rodenburg, Dzhamilja Safiulina, Tim M Strom, Inga Talvik, Annika Vaarmann, Callum Wilson, Allen Kaasik, Tobias B Haack, Katrin Õunap
Variants in the SPATA5 gene were recently described in a cohort of patients with global developmental delay, sensorineural hearing loss, seizures, cortical visual impairment and microcephaly. SPATA5 protein localizes predominantly in the mitochondria and is proposed to be involved in mitochondrial function and brain developmental processes. However no functional studies have been performed. This study describes five patients with psychomotor developmental delay, microcephaly, epilepsy and hearing impairment, who were thought clinically to have a mitochondrial disease with subsequent whole-exome sequencing analysis detecting compound heterozygous variants in the SPATA5 gene...
January 17, 2018: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/29343766/sudden-sensory-neural-hearing-loss-is-not-predictive-of-myocardial-infarction-a-longitudinal-follow-up-study-using-a-national-sample-cohort
#12
So Young Kim, Songyong Sim, Hyung-Jong Kim, Hyo Geun Choi
The aim of this study was to evaluate the risk of myocardial infarction (MI) in SSNHL subjects with differently matched control groups. The Korean Health Insurance Review and Assessment Service - National Sample Cohort recruited subjects from 2002 to 2013. We used two study designs. In study I, we matched 4,467 SSNHL participants with a control group (17,868 subjects with no history of SSNHL) based on demographic factors (age, sex, income, and region of residence) and medical history (diabetes, dyslipidemia, and hypertension)...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29342440/the-critical-warning-sign-of-real-time-brainstem-auditory-evoked-potentials-during-microvascular-decompression-for-hemifacial-spasm
#13
Sang-Ku Park, Byung-Euk Joo, Seunghoon Lee, Jeong-A Lee, Jeong-Ho Hwang, Doo-Sik Kong, Dae-Won Seo, Kwan Park, Hoon-Taek Lee
OBJECTIVE: The aim of this study was to define the critical warning sign of real-time brainstem auditory evoked potential (BAEP) for predicting hearing loss (HL) after microvascular decompression (MVD) for hemifacial spasm (HFS). METHODS: Nine hundred and thirty-two patients with HFS who underwent MVD with intraoperative monitoring (IOM) of BAEP were analyzed. We used a 43.9 Hz/s stimulation rate and 400 averaging trials to obtain BAEP. To evaluate HL, pure-tone audiometry and speech discrimination scoring were performed before and one week after surgery...
January 4, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29342223/development-of-a-job-exposure-matrix-for-noise-in-the-swedish-soft-tissue-paper-industry
#14
Richard Lee Neitzel, Marianne Andersson, Helena Eriksson, Kjell Torén, Eva Andersson
Objectives: Noise exposure is a common occupational hazard, but has not been sufficiently characterized in paper mills. We developed a job-exposure matrix (JEM) for noise exposure for use in estimating exposures among Swedish soft tissue paper mill workers. Methods: We used a combination of area and personal dosimetry noise exposure measurements made at four soft tissue paper mills by industry and research staff between 1977 and 2013 to estimate noise exposures by department, location, and job title...
December 16, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/29342057/audiologic-natural-history-of-small-volume-cochleovestibular-schwannomas-in-neurofibromatosis-type-2
#15
Alvin T deTorres, Carmen C Brewer, Chris K Zalewski, Kelly A King, Robert Walker, Gretchen C Scott, Ashok R Asthagiri, Prashant Chittiboina, Hung Jeffrey Kim
OBJECTIVE: To characterize the audiometric natural progression in patient-ears with small volume (<1,000 mm), treatment-naïve cochleovestibular schwannomas (CVSs) in Neurofibromatosis Type 2 (NF2). STUDY DESIGN: Prospective, longitudinal cohort study. SETTING: Quaternary medical research institute. PATIENTS: One hundred eleven ears in 71 NF2 patients with small, treatment-naïve CVSs observed from July 2006 to July 2016...
January 16, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29342054/multicenter-us-clinical-trial-with-an-electric-acoustic-stimulation-eas-system-in-adults-final-outcomes
#16
Harold C Pillsbury, Margaret T Dillon, Craig A Buchman, Hinrich Staecker, Sandra M Prentiss, Michael J Ruckenstein, Douglas C Bigelow, Fred F Telischi, Diane M Martinez, Christina L Runge, David R Friedland, Nikolas H Blevins, Jannine B Larky, George Alexiades, David M Kaylie, Peter S Roland, Richard T Miyamoto, Douglas D Backous, Frank M Warren, Hussam K El-Kashlan, Heidi K Slager, Carisa Reyes, Allison I Racey, Oliver F Adunka
OBJECTIVE: To demonstrate the safety and effectiveness of the MED-EL Electric-Acoustic Stimulation (EAS) System, for adults with residual low-frequency hearing and severe-to-profound hearing loss in the mid to high frequencies. STUDY DESIGN: Prospective, repeated measures. SETTING: Multicenter, hospital. PATIENTS: Seventy-three subjects implanted with PULSAR or SONATA cochlear implants with FLEX electrode arrays. INTERVENTION: Subjects were fit postoperatively with an audio processor, combining electric stimulation and acoustic amplification...
January 16, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29342053/gradual-symmetric-progression-of-dfna34-hearing-loss-caused-by-an-nlrp3-mutation-and-cochlear-autoinflammation
#17
Hiroshi Nakanishi, Yoshiyuki Kawashima, Kiyoto Kurima, Julie A Muskett, H Jeffrey Kim, Carmen C Brewer, Andrew J Griffith
OBJECTIVE: To characterize the audiometric phenotype of autosomal-dominant DFNA34 hearing loss (HL) caused by a missense substitution in the NLRP3 gene. NLRP3 encodes a critical component of the NLRP3 inflammasome that is activated in innate immune responses. STUDY DESIGN: This study was conducted under protocol 01-DC-0229 approved by the NIH Combined Neurosciences IRB. We performed medical and developmental history interviews and physical and audiological examinations of affected individuals with DFNA34 HL caused by the p...
January 16, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29342040/unilateral-sensorineural-hearing-loss-presenting-with-bilateral-temporal-bone-lesions
#18
Mark Sakai, Cameron C Wick, Joe Walter Kutz
No abstract text is available yet for this article.
January 16, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29342037/preservation-of-cells-of-the-organ-of-corti-and-innervating-dendritic-processes-following-cochlear-implantation-in-the-human-an-immunohistochemical-study
#19
Takefumi Kamakura, Jennifer T O'Malley, Joseph B Nadol
HYPOTHESIS: This study evaluates the degree of preservation of hair cells, supporting cells, and innervating dendritic processes after cochlear implantation in the human using immunohistochemical methods. BACKGROUND: Surgical insertion of a cochlear implant electrode induces various pathologic changes within the cochlea including insertional trauma, foreign body response, inflammation, fibrosis, and neo-osteogenesis. These changes may result in loss of residual acoustic hearing, adversely affecting the use of hybrid implants, and may result in loss of putative precursor cells, limiting the success of future regenerative protocols...
January 16, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29341316/deferoxamine-promotes-mesenchymal-stem-cell-homing-in-noise-induced-injured-cochlea-through-pi3k-akt-pathway
#20
A A Peyvandi, H-A Abbaszadeh, N Ahmady Roozbahany, A Pourbakht, S Khoshsirat, H Haddadzade Niri, H Peyvandi, S Niknazar
OBJECTIVE: Over 5% of the world's population suffers from disabling hearing loss. Stem cell homing in target tissue is an important aspect of cell-based therapy, which its augmentation increases cell therapy efficiency. Deferoxamine (DFO) can induce the Akt activation, and phosphorylation status of AKT (p-AKT) upregulates CXC chemokine receptor-4 (CXCR4) expression. We examined whether DFO can enhance mesenchymal stem cells (MSCs) homing in noise-induced damaged cochlea by PI3K/AKT dependent mechanism...
January 17, 2018: Cell Proliferation
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