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https://www.readbyqxmd.com/read/28441710/analysis-of-cisplatin-induced-ototoxicity-risk-factors-in-iranian-patients-with-solid-tumors-a-cohort-prospective-and-single-institute-study
#1
Zahra Esfahani Monfared, Adnan Khosravi, Ali Safavi Naini, Golnar Radmand, Kian Khodadad
Background: Cisplatin has been associated with irreversible hearing damage. Up to now, there is no therapeutic intervention showing benefit in preventing Cisplatin-induced ototoxicity. The aim of this study was to determine risk factors contributing to hearing impairment after cisplatin administration in Iranian patients. Methods: Hearing thresholds of 124 patients before and after cisplatin administration were assessed with reference to pure-tone audiometry averages at several frequencies from 2006 to 2010...
March 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28441318/retraction-yu-et-al-low-iron-diet-increases-susceptibility-to-noise-induced-hearing-loss-in-young-rats-nutrients-2016-8-456
#2
Nutrients Editorial Office
The Nutrients Editorial Office has recently been made aware that the figures in the title paper [1] are taken from the same micrographs as those of other papers by the same authors [...].
April 25, 2017: Nutrients
https://www.readbyqxmd.com/read/28441230/cochlear-implantation-in-adults-with-asymmetric-hearing-loss-benefits-of-bimodal-stimulation
#3
Maarten Caspar van Loon, Cas Smits, Conrad F Smit, Erik F Hensen, Paul Merkus
OBJECTIVE: This study addresses the outcome of cochlear implantation in addition to hearing aid use in patients with asymmetric sensorineural hearing loss. STUDY DESIGN: Prospective longitudinal study. SETTING: Tertiary referral center. PATIENTS: Seven adults with asymmetric sensorineural hearing loss, i.e., less than 30% aided speech recognition in their worst hearing ear and 60 to 85% speech recognition in their best hearing ear...
April 24, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28441229/preliminary-model-for-the-design-of-a-custom-middle-ear-prosthesis
#4
Brandon Kamrava, Jonathan A Gerstenhaber, Mamta Amin, Yah-El Har-El, Pamela C Roehm
HYPOTHESIS: Custom prostheses could be used to recreate the ossicular chain and improve hearing. BACKGROUND: Ossicular discontinuity or fixation occurs in 55% of cases of conductive hearing loss, with most cases involving the incus. Reconstruction has been achieved by a variety of methods; however, there has been little improvement in hearing outcomes in decades. METHODS: Precise measurements of anatomic dimensions, weight, and center of gravity were taken from 19 cadaveric incudes...
April 24, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28441153/discharge-criteria-for-the-late-preterm-infant-a-review-of-the-literature
#5
Jenny M Quinn, Marteen Sparks, Sheila M Gephart
BACKGROUND: Standardized late preterm infant (LPI) discharge criteria ensure best practice and help guide the neonatal provider to determine the appropriate level of care following birth. However, the location can vary from the well newborn setting to the neonatal intensive care unit (NICU). PURPOSE: The purpose of this review is to examine differences in LPI discharge criteria between the well newborn setting and the NICU by answering the clinical questions, "What are the recommended discharge criteria for the LPI and do they differ if admitted to the well newborn setting versus the NICU?" SEARCH STRATEGY: Databases searched include CINAHL, TRIP, PubMed, and the Cochrane Library...
April 24, 2017: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
https://www.readbyqxmd.com/read/28440726/expression-of-c-type-lectin-receptor-mrna-in-chronic-otitis-media-with-cholesteatoma
#6
Sang Hoon Kim, Seung-Ho Han, Jae Yong Byun, Moon Suh Park, Young Il Kim, Seung Geun Yeo
CONCLUSIONS: The levels of expression of various C-type lectin receptors (CLRs) messenger ribo nucleic acids (mRNAs) were significantly higher in cholesteatomas than in normal skin, suggesting that these CLRs may be involved in the pathogenesis of cholesteatoma. OBJECTIVES: Altered expression of pattern recognition receptors may be associated with immune responses in patients with cholesteatoma. This study assessed the levels of expression of CLR mRNAs in normal skin and in cholesteatoma...
June 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28439223/outer-hair-cell-and-auditory-nerve-function-in-speech-recognition-in-quiet-and-in-background-noise
#7
Richard Hoben, Gifty Easow, Sofia Pevzner, Mark A Parker
The goal of this study was to describe the contribution of outer hair cells (OHCs) and the auditory nerve (AN) to speech understanding in quiet and in the presence of background noise. Fifty-three human subjects with hearing ranging from normal to moderate sensorineural hearing loss were assayed for both speech in quiet (Word Recognition) and speech in noise (QuickSIN test) performance. Their scores were correlated with OHC function as assessed via distortion product otoacoustic emissions, and AN function as measured by amplitude, latency, and threshold of the VIIIth cranial nerve Compound Action Potential (CAP) recorded during electrocochleography (ECochG)...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28438970/the-severity-of-vestibular-dysfunction-in-deafness-as-a-determinant-of-comorbid-hyperactivity-or-anxiety
#8
Michelle W Antoine, Sarath Vijayakumar, Nicholas McKeehan, Sherri M Jones, Jean M Hébert
Attention-deficit/hyperactivity disorder (ADHD) and anxiety-related disorders occur at rates 2-3 times higher in deaf compared with hearing children. Potential explanations for these elevated rates and the heterogeneity of behavioral disorders associated with deafness have usually focused on socio-environmental rather than biological effects. Children with the 22q11.2 deletion or duplication syndromes often display hearing loss and behavioral disorders including ADHD and anxiety-related disorders. Here, we show that mouse mutants with either a gain- or loss-of-function of the T-Box transcription factor gene, Tbx1, which lies within the 22q11...
April 24, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28438730/impact-of-hearing-loss-on-medical-consultations-is-largely-overlooked-review-finds
#9
Susan Mayor
No abstract text is available yet for this article.
April 24, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28437363/intratympanic-dexamethasone-in-the-treatment-of-m%C3%A3-ni%C3%A3-re-s-disease-a-comparison-of-two-techniques
#10
Jason A Beyea, Ryan S Instrum, Sumit K Agrawal, Lorne S Parnes
OBJECTIVE: To assess the efficacy and safety of two different intratympanic dexamethasone (IT Dex) injection protocols for intractable unilateral Ménière's disease. STUDY DESIGN: Prospective case series. SETTING: Tertiary neurotology clinic. PATIENTS: One hundred six consecutive adult patients with definite unilateral Ménière's disease who had failed medical management were studied for an average of 1,061 days. None had previous oral steroid, IT steroid, or ablative treatment...
April 21, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28437273/assessing-sensorineural-hearing-loss-using-various-transient-evoked-otoacoustic-emission-stimulus-conditions
#11
Daniel B Putterman, Douglas H Keefe, Lisa L Hunter, Angela C Garinis, Denis F Fitzpatrick, Garnett P McMillan, M Patrick Feeney
OBJECTIVES: An important clinical application of transient-evoked otoacoustic emissions (TEOAEs) is to evaluate cochlear outer hair cell function for the purpose of detecting sensorineural hearing loss (SNHL). Double-evoked TEOAEs were measured using a chirp stimulus, in which the stimuli had an extended frequency range compared to clinical tests. The present study compared TEOAEs recorded using an unweighted stimulus presented at either ambient pressure or tympanometric peak pressure (TPP) in the ear canal and TEOAEs recorded using a power-weighted stimulus at ambient pressure...
April 21, 2017: Ear and Hearing
https://www.readbyqxmd.com/read/28436026/studies-of-physician-patient-communication-with-older-patients-how-often-is-hearing-loss-considered-a-systematic-literature-review
#12
Jamie M Cohen, Jan Blustein, Barbara E Weinstein, Hannah Dischinger, Scott Sherman, Corita Grudzen, Joshua Chodosh
Hearing loss is remarkably prevalent in the geriatric population: one-quarter of adults aged 60-69 and 80% of adults aged 80 years and older have bilateral disabling loss. Only about one in five adults with hearing loss wears a hearing aid, leaving many vulnerable to poor communication with healthcare providers. We quantified the extent to which hearing loss is mentioned in studies of physician-patient communication with older patients, and the degree to which hearing loss is incorporated into analyses and findings...
April 24, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28434756/evaluation-of-tinnitus-retraining-therapy-for-patients-with-normal-audiograms-versus-patients-with-hearing-loss
#13
Kana Lee, Kunihiko Makino, Kohei Yamahara
OBJECTIVE: A few chronic tinnitus patients show normal hearing thresholds in the pure tone audiometry from 125Hz to 8000Hz (≤20dB). We report the characteristics of the course of those patients underwent tinnitus retraining therapy (TRT) compared with other patients suffering from chronic and severe tinnitus. METHODS: We identified 13 patients with normal hearing thresholds among 242 patients suffering over 3 months, Tinnitus Handicap Inventory (THI) ≥16/100, and follow up period is over 6 months...
April 20, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28434581/hearing-loss-and-auditory-plasticity
#14
EDITORIAL
Wei Sun, Shiming Yang, Ke Liu, Richard J Salvi
No abstract text is available yet for this article.
April 2017: Hearing Research
https://www.readbyqxmd.com/read/28434272/wideband-acoustic-immittance-in-children-with-down-syndrome-prediction-of-middle-ear-dysfunction-conductive-hearing-loss-and-patent-pe-tubes
#15
Lisa L Hunter, Douglas H Keefe, M Patrick Feeney, David K Brown, Jareen Meinzen-Derr, Alaaeldin M Elsayed, Julia M Amann, Vairavan Manickam, Denis Fitzpatrick, Sally R Shott
OBJECTIVE: The purpose of this study was to evaluate pressurised wideband acoustic immittance (WAI) tests in children with Down syndrome (DS) and in typically developing children (TD) for prediction of conductive hearing loss (CHL) and patency of pressure equalising tubes (PETs). DESIGN: Audiologic diagnosis was determined by audiometry in combination with distortion-product otoacoustic emissions, 0.226 kHz tympanometry and otoscopy. WAI results were compared for ears within diagnostic categories (Normal, CHL and PET) and between groups (TD and DS)...
April 22, 2017: International Journal of Audiology
https://www.readbyqxmd.com/read/28434002/in-situ-hearing-tests-for-the-purpose-of-a-self-fit-hearing-aid
#16
Monique Boymans, Wouter A Dreschler
This study investigated the potential and limitations of a self-fit hearing aid. This can be used in the "developing" world or in countries with large distances between the hearing-impaired subjects and the professional. It contains an on-board tone generator for in situ user-controlled, automated audiometry, and other tests for hearing aid fitting. Twenty subjects with mild hearing losses were involved. In situ audiometry showed a test-retest reliability (SD <3.7 dB) that compared well with the precision of diagnostic audiometry using headphones...
April 22, 2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/28433849/clinical-significance-of-long-term-follow-up-of-children-with-posttraumatic-skull-base-fracture
#17
Sharon Leibu, Guy Rosenthal, Yigal Shoshan, Mony Benifla
BACKGROUND: To assess in children with skull base fractures, incidences of cerebrospinal fluid (CSF) leak, meningitis, and the need for prophylactic antibiotics, anti-pneumococcal vaccination, and surgical interventions. METHODS: We reviewed the records of children with skull base fractures who were admitted to our tertiary care center during 2009-2014. RESULTS: 196 children (153 male) were hospitalized with skull base fractures, aged 1 month to 18 years (mean 6 ± 4 years)...
April 19, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28432874/delayed-changes-in-auditory-status-in-cochlear-implant-users-with-preserved-acoustic-hearing
#18
Rachel A Scheperle, Viral D Tejani, Julia K Omtvedt, Carolyn J Brown, Paul J Abbas, Marlan R Hansen, Bruce J Gantz, Jacob J Oleson, Marie V Ozanne
This retrospective review explores delayed-onset hearing loss in 85 individuals receiving cochlear implants designed to preserve acoustic hearing at the University of Iowa Hospitals and Clinics between 2001 and 2015. Repeated measures of unaided behavioral audiometric thresholds, electrode impedance, and electrically evoked compound action potential (ECAP) amplitude growth functions were used to characterize longitudinal changes in auditory status. Participants were grouped into two primary categories according to changes in unaided behavioral thresholds: (1) stable hearing or symmetrical hearing loss and (2) delayed loss of hearing in the implanted ear...
April 12, 2017: Hearing Research
https://www.readbyqxmd.com/read/28432353/severe-hearing-loss-and-outer-hair-cell-death-in-homozygous-foxo3-knockout-mice-after-moderate-noise-exposure
#19
Felicia Gilels, Stephen T Paquette, Holly J Beaulac, Anwen Bullen, Patricia M White
Noise induced hearing loss (NIHL) is a disease that affects millions of Americans. Identifying genetic pathways that influence recovery from noise exposure is an important step forward in understanding NIHL. The transcription factor Foxo3 integrates the cellular response to oxidative stress and plays a role in extending lifespan in many organisms, including humans. Here we show that Foxo3 is required for auditory function after noise exposure in a mouse model system, measured by ABR. Absent Foxo3, outer hair cells are lost throughout the middle and higher frequencies...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28432340/phenome-wide-association-study-for-cyp2a6-alleles-rs113288603-is-associated-with-hearing-loss-symptoms-in-elderly-smokers
#20
Renato Polimanti, Kevin P Jensen, Joel Gelernter
To identify novel phenotypic associations related to Cytochrome P450 Family 2 Subfamily A Member 6 (CYP2A6), we investigated the human phenome in a total of 11,271 individuals. Initially, we conducted a phenome-wide association study in 3,401 nicotine-exposed elderly subjects considering 358 phenotypic traits. We identified a significant association between CYP2A6 rs113288603 and hearing loss symptoms (p = 5.75 × 10(-5)). No association was observed in a sample of 3,245 nicotine-unexposed individuals from the same discovery cohort, consistent with the conclusion that the finding is related to CYP2A6 involvement in nicotine metabolism...
April 21, 2017: Scientific Reports
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