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https://www.readbyqxmd.com/read/28532040/design-synthesis-and-characterization-of-poly-methacrylic-acid-niclosamide-and-its-effect-on-arterial-function
#1
Rui Ma, Zhen-Gang Ma, Chang-Lin Zhen, Xin Shen, Shan-Liang Li, Li Li, Yu-Feng Zheng, De-Li Dong, Zhi-Jie Sun
We have found that niclosamide induced relaxation of constricted artery. However, niclosamide is insoluble, the low bioavailability and the resultant low plasma concentration limit its potential exertion in vivo. The aim of the present study is to synthesize a soluble poly (methacrylic acid-niclosamide) polymer (PMAN) and study the effects of PMAN on arterial function in vitro and the blood pressure and heart rate of rats in vivo. We synthesized the poly (methacrylic acid-niclosamide) polymer (PMAN), the chemical structure of which was identified by FTIR and (1)H NMR spectra...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28528595/implications-of-white-striping-and-spaghetti-meat-abnormalities-on-meat-quality-and-histological-features-in-broilers
#2
G Baldi, F Soglia, M Mazzoni, F Sirri, L Canonico, E Babini, L Laghi, C Cavani, M Petracci
During the past few years, there has been an increasing prevalence of broiler breast muscle abnormalities, such as white striping (WS) and wooden breast conditions. More recently, a new muscular abnormality termed as spaghetti meat (SM) because of the altered structural integrity of the Pectoralis major muscle often associated with WS has emerged. Thus, this study aimed at evaluating the effects of WS and SM conditions, occurring alone or combined within the same P. major muscle, on meat quality traits and muscle histology...
May 22, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28518407/nad-a-big-player-in-cardiac-and-skeletal-muscle-remodeling-and-aging
#3
REVIEW
Pankaj Chaturvedi, Suresh C Tyagi
In the past decade, NAD+ has gained importance for its beneficial effects as antioxidant and antiaging molecule. A paper in science by Zhang et al (2016) has described that NAD+ when replenished, ameliorates muscle dystrophy in mice by improving mitochondrial function. NAD+ was also demonstrated by the authors to improve the life span of mice. Cox et al (2002) demonstrated the cardiac effects of NAD+ which mitigated chronic heart failure via mitochondrial redox state mechanism. Cox et al (2002) also demonstrated that NAD+ is provided in the drinking water, it improves cardiac relaxation in volume overload model of heart failure...
May 18, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28515177/do-%C3%AE-3-adrenoceptor-agonists-cause-urinary-bladder-smooth-muscle-relaxation-by-inhibiting-acetylcholine-release
#4
Katerina Okeke, Stavros Gravas, Martin C Michel
The mechanisms leading to improvement of overactive bladder syndrome upon treatment with a β3-adrenoceptor agonist remain controversial. New research points to a role of inhibition of neuronal acetylcholine release. Whether this occurs by a direct effect on prejunctional β3-adrenoceptors or indirectly by formation of adenosine and activation of A1 adenosine receptors is being discussed.
May 17, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28515053/berberine-reduced-blood-pressure-and-improved-vasodilation-in-diabetic-rats
#5
Yu-Guang Ma, Liang Liang, Yin-Bin Zhang, Bao-Feng Wang, Yun-Gang Bai, Zhi-Jun Dai, Man-Jiang Xie, Zhong-Wei Wang
Hyperglycemia and hypertension are considered to be the two leading risk factors for vascular disease in diabetic patients. However, few pharmacologic agents could provide a combinational therapy for controlling hyperglycemia and hypertension at the same time in diabetes. We aimed to investigate whether berberine treatment could directly reduce blood pressure in diabetes and what is the molecular mechanism underlying the vascular protection of berberine in diabetic rats. Berberine (50, 100, and 200 mg/kg/day) was intragastrically administered to diabetic rats for 8 weeks since the injection of streptozotocin...
May 17, 2017: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/28509775/failed-vocalis-muscle-monitoring-during-thyroid-surgery-resulting-from-residual-muscle-relaxation
#6
Stuart D Marshall, Jonathan Serpell
No abstract text is available yet for this article.
May 12, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/28509762/beetroot-juice-increases-human-muscle-force-without-changing-ca2-handling-proteins
#7
Jamie Whitfield, Daniel Gamu, George J F Heigenhauser, Luc J C van Loon, Lawrence L Spriet, A Russell Tupling, Graham P Holloway
Dietary inorganic nitrate (NO3) supplementation improves skeletal muscle (SkM) contractile efficiency, and while rodent literature has suggested improvements in calcium handling or redox modifications as likely explanations, the direct mechanism-of-action in humans remains unknown. PURPOSE: To examine the effects of 7-d of beetroot juice (BRJ) supplementation on SkM contractile characteristics and function. METHODS: Recreationally active males (n=8) underwent transcutaneous electrical muscle stimulation of the vastus lateralis for evaluation of contractile characteristics before (pre) and after (post) 7-d of BRJ supplementation (280 mL/day, ~26 mmol NO3)...
May 15, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28502777/peripheral-muscle-fatigue-in-hospitalised-geriatric-patients-is-associated-with-circulating-markers-of-inflammation
#8
Pauline Arnold, Rose Njemini, Stijn Vantieghem, Jacques Duchateau, Tony Mets, Ingo Beyer, Ivan Bautmans
Geriatric patients with acute infection show increased muscle weakness and fatigability but the relative contribution of central and peripheral factors is unclear. Hospitalised patients with acute infection (82±6years, N=10) and community-dwelling controls (76±6years, N=19) sustained a maximal voluntary isometric contraction of the M. Adductor Pollicis until strength dropped to 50% of its maximal value. Voluntary muscle activation (VA) was assessed before and at the end of the fatigue protocol using twitch interpolation method and muscle activity was monitored using surface electromyography...
May 10, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28502541/prolonged-stance-phase-during-walking-in-intermittent-claudication
#9
Lindy N M Gommans, Annemieke T Smid, Marc R M Scheltinga, Ernst Cancrinus, Frans A M Brooijmans, Kenneth Meijer, Joep A W Teijink
BACKGROUND: Patients with intermittent claudication (IC) tend to walk slower and consume approximately 40% more oxygen during walking compared with healthy individuals. An unfavorable locomotion pattern has been suggested to explain this metabolic inefficiency. However, detailed knowledge of gait parameters in IC is lacking. METHODS: In a cross-sectional study, the gait pattern of newly diagnosed IC patients was compared with that of healthy controls. Spatiotemporal gait parameters such as step length and duration of stance phase were obtained by a photoelectric technique (OptoGait; Microgate, Bolzano, Italy)...
May 11, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28502408/combined-effect-of-low-back-muscle-fatigue-and-passive-tissue-elongation-on-the-flexion-relaxation-response
#10
Sangeun Jin, Gary A Mirka
Previous literature has documented the alterations in the flexion-relaxation response of the lumbar extensor musculature to passive tissue elongation (PTE) and muscle fatigue (MF). There is no study, however, that has explored this response as a function of the combined effect of both PTE and MF, which is often seen in occupational settings. Twelve participants performed three experimental protocols on three different days to achieve (1) PTE, (2) MF and (3) PTE&MF (combined). Trunk kinematics and muscle activities were monitored to assess the effects of these protocols on the peak lumbar flexion angle and the lumbar angle of the flexion-relaxation of the trunk extensor muscles...
September 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/28501682/the-role-of-arachidonic-acid-cyclooxygenase-cascade-phosphodiesterase-iv-and-rho-kinase-in-h2s-induced-relaxation-in-the-mouse-corpus-cavernosum
#11
Fatma Aydinoglu, Nuran Ogulener
BACKGROUND: Penile corpus cavernosum is an extremely vascularized tissue and cavernosal smooth muscle tone is regulated by the balance between contractile and relaxant factor. We investigated the possible role of arachidonic acid/cyclooxygenase cascade, phosphodiesterase IV (PDEIV) and Rho-kinase in exogenous hydrogen sulfide (H2S)-induced relaxation in mouse corpus cavernosum. METHODS: The relaxant response to H2S (NaHS as exogenous H2S; 1-1000μM) were obtained in isolated mouse corpus cavernosum tissues which pre-contracted by phenylephrine (5μM)...
February 24, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28497497/simultaneous-measurement-of-macro-and-microvascular-blood-flow-and-oxygen-saturation-for-quantification-of-muscle-oxygen-consumption
#12
Erin K Englund, Zachary B Rodgers, Michael C Langham, Emile R Mohler, Thomas F Floyd, Felix W Wehrli
PURPOSE: To investigate the relationship between blood flow and oxygen consumption in skeletal muscle, a technique called "Velocity and Perfusion, Intravascular Venous Oxygen saturation and T2*" (vPIVOT) is presented. vPIVOT allows the quantification of feeding artery blood flow velocity, perfusion, draining vein oxygen saturation, and muscle T2*, all at 4-s temporal resolution. Together, the measurement of blood flow and oxygen extraction can yield muscle oxygen consumption ( V˙O2) via the Fick principle...
May 11, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28497396/progressive-muscle-relaxation-combined-with-chinese-medicine-five-element-music-on-depression-for-cancer-patients-a-randomized-controlled-trial
#13
Juan Liao, Yu Wu, Yang Zhao, Yuan-Chen Zhao, Xu Zhang, Nan Zhao, Chun-Ging Lee, Yu-Fei Yang
OBJECTIVES: To evaluate the effects of progressive muscle relaxation training (PMRT) combined with fifive elements music therapy of Chinese medicine (CM) for improving anxiety and depression of cancer patients. METHODS: From June 2015 to March 2016, 60 cancer patients were included into the study. The patients were randomly assigned to a control group and a treatment group by envelope randomization, receiving PMRT and PMRT plus CM five elements music therapy, respectively, for 8 weeks...
May 11, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28495786/speaking-fluently-with-baclofen
#14
Esther Beraha, Pieter Bodewits, Wim van den Brink, Reinout Wiers
Baclofen is a new and promising pharmacological compound for the treatment of alcohol dependence (AD). Although several randomised trials found a reduction of craving and higher abstinence rates with low and high doses of baclofen, others failed to show positive effects. In this case study, the successful treatment of a patient with AD with daily 120 mg of baclofen is described. In addition to a decrease in alcohol use, we observed the cessation of stuttering during treatment with baclofen, reoccurrence of stuttering following discontinuation, and cessation of stuttering after reinstatement of the treatment...
May 11, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28493923/brief-relaxation-training-is-not-sufficient-to-alter-tolerance-to-experimental-pain-in-novices
#15
Karen E Smith, Greg J Norman
Relaxation techniques, such as deep breathing and muscle relaxation, are aspects common to most forms of mindfulness training. There is now an abundance of research demonstrating that mindfulness training has beneficial effects across a wide range of clinical conditions, making it an important tool for clinical intervention. One area of extensive research is on the beneficial effects of mindfulness on experiences of pain. However, the mechanisms of these effects are still not well understood. One hypothesis is that the relaxation components of mindfulness training, through alterations in breathing and muscle tension, leads to changes in parasympathetic and sympathetic nervous system functioning which influences pain circuits...
2017: PloS One
https://www.readbyqxmd.com/read/28492791/respiratory-muscle-training-improves-diaphragm-citrate-synthase-activity-and-hemodynamic-function-in-rats-with-heart-failure
#16
Rodrigo Boemo Jaenisch, Mariane Bertagnolli, Audrey Borghi-Silva, Ross Arena, Pedro Dal Lago
INTRODUCTION: Enhanced respiratory muscle strength in patients with heart failure positively alters the clinical trajectory of heart failure. In an experimental model, respiratory muscle training in rats with heart failure has been shown to improve cardiopulmonary function through mechanisms yet to be entirely elucidated. OBJECTIVE: The present report aimed to evaluate the respiratory muscle training effects in diaphragm citrate synthase activity and hemodynamic function in rats with heart failure...
March 2017: Brazilian Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/28489258/triggered-and-tunable-hydrogen-sulfide-release-from-photo-generated-thiobenzaldehydes
#17
Zeyun Xiao, Thomas Bonnard, Aida Shakouri-Motlagh, Ross Wylie, Joe Collins, Daniel Heath, Christoph Hagemeyer, Luke Connal
Hydrogen sulfide (H2S) has been identified as an important cell signaling mediator and has a number of biological functions such as vascular smooth muscle relaxation, neurotransmission and regulation of inflammation. Here we develop a facile and versatile approach for H2S production initiated by light irradiation and controlled by reaction with an amine or an amino acid. The donor is synthesized in a one-pot reaction and simple crystallization leads to ~90% yield. The synthetic strategy we have devised is scalable and versatile; we demonstrate that the H2S donors can be expressed in number of different molecular and macromolecular forms including crystalline small molecules, water soluble polymers, polystyrene films, and hydrogels...
May 10, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28487373/interactions-between-small-ankyrin-1-and-sarcolipin-coordinately-regulate-activity-of-the-sarco-endo-plasmic-reticulum-ca2-atpase-serca1
#18
Patrick F Desmond, Amanda Labuza, Joaquin Muriel, Michele L Markwardt, Allison E Mancini, Mark A Rizzo, Robert J Bloch
SERCA1, the sarco(endo)plasmic reticulum Ca2+-ATPase of skeletal muscle, is essential for muscle relaxation and maintenance of low resting Ca2+ levels in the myoplasm. We recently reported that small ankyrin 1 (sAnk1) interacts with the sarco(endo)plasmic reticulum Ca2+-ATPase in skeletal muscle (SERCA1) to inhibit its activity (1). We also showed that this interaction is mediated at least in part through sAnk1's transmembrane domain in a manner similar to that of sarcolipin (SLN). Earlier studies have shown that SLN and phospholamban (PLN), the other well-studied small SERCA-regulatory proteins, oligomerize either alone or together...
May 9, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28487215/micturition-dysfunction-in-four-month-old-ovariectomized-rats-effects-of-testosterone-replacement
#19
Sandra M Bonilla-Becerra, Mariana G de Oliveira, Fabiano B Calmasini, Julio A Rojas-Moscoso, Angelina Zanesco, Edson Antunes
AIMS: Androgen deficiency has been implicated in urological complications of postmenopausal women. This study examined the effects of testosterone replacements on the lower urinary tract dysfunction in 4-month old ovariectomized (OVX) rats. MAIN METHODS: Sprague-Dawley female rats were OVX bilaterally. Three months later, rats received single intramuscular injections of testosterone undecanoate. Cystometric study, and bladder and urethra smooth muscle reactivities were evaluated...
May 6, 2017: Life Sciences
https://www.readbyqxmd.com/read/28486910/clinical-significance-of-the-sympathetic-nervous-system-in-the-development-and-progression-of-pulmonary-arterial-hypertension
#20
Ru-Xia Liu, Qian Luo, Hui Qiao, Juan Yu, Qian-Long Zhang, Peng Wang, Yong-Gang Cao, Chang-Lin Jiang, Li-Hui Qu
Pulmonary arterial hypertension (PAH) is defined as a complex disease of clinically characterized by elevated pulmonary pressure eventually resulting in right heart failure and premature death. To date, PAH still remains a life-threatening disease. Published evidence suggests that patients with PAH present profound sympathetic nervous system abnormalities and sympathetic activity has been shown to be increased. The mechanism of PAH is still complex and poorly understood. <p> Results: Some data have showed that adrenoceptors are involved in the process of the pathology and have different functions in the progression of PAH followed by heart failure...
January 12, 2017: Current Neurovascular Research
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