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radiation cognition

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https://www.readbyqxmd.com/read/28288921/therapy-for-recurrent-high-grade-gliomas-results-of-a-prospective-multicenter-study-on-health-related-quality-of-life
#1
Linda Stöckelmaier, Mirjam Renovanz, Jochem König, Katrin Nickel, Anne-Katrin Hickmann, Regine Mayer-Steinacker, Minou Nadji-Ohl, Oliver Ganslandt, Lars Bullinger, Christian Rainer Wirtz, Jan Coburger
OBJECTIVE: To assess impact of therapy on patients' health-related quality of life (HRQoL) in recurrent high-grade glioma (HGG) in an unselected cohort. METHODS: In this prospective multicenter study, we analyzed EORTC QLQ-C30 and BN20 questionnaires of 92 patients within one year after diagnosis of tumor recurrence of a HGG and respective treatment. We evaluated the influence of re-radiation, second and third-line chemotherapies and number of recurrent surgeries on sum scores for functioning, symptoms and total score as well as on sub scores for functioning and neurological symptoms using multivariate mixed models and descriptive statistics...
March 10, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28274393/low-dose-cranial-boost-in-high-risk-adult-acute-lymphoblastic-leukemia-patients-undergoing-bone-marrow-transplant
#2
William Su, Marcher Thompson, Ren-Dih Sheu, Amir Steinberg, Luis Isola, Richard Stock, Richard L Bakst
PURPOSE: Acute lymphoblastic leukemia (ALL) has a predilection for CNS involvement. Patients with high-risk ALL are often managed with transplant using a radiation-based conditioning regimen. Historically, a high-dose prophylactic cranial boost (CB) of ≥12 Gy was given to reduce risk of central nervous system (CNS) recurrence. However, the use of CB has fallen out of favor because of toxicity concerns. In high-risk adults undergoing transplant at our institution, we have used a low-dose 6 Gy CB to reduce toxicity while conditioning adults with fully developed brains...
March 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28258899/are-future-radiation-oncologists-equipped-with-the-knowledge-to-manage-elderly-patients-with-cancer
#3
Lucinda Morris, Niluja Thiruthaneeswaran, Margot Lehman, Gina Hasselburg, Sandra Turner
PURPOSE: To assess radiation oncology (RO) trainee knowledge, attitudes, and clinical practice relating to geriatric oncology. METHODS AND MATERIALS: A custom online survey was anonymously administered to RO trainees across Australia, New Zealand, and Singapore. The survey assessed 3 domains: (1) trainee demographics and prior training in geriatric medicine; (2) current clinical practice and attitudes regarding elderly cancer patients and radiation therapy; and (3) opinions regarding educational opportunities around geriatric oncology...
January 9, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28248991/limbic-thalamo-cortical-projections-and-reward-related-circuitry-integrity-affects-eating-behavior-a-longitudinal-dti-study-in-adolescents-with-restrictive-eating-disorders
#4
Gaia Olivo, Lyle Wiemerslage, Ingemar Swenne, Christina Zhukowsky, Helena Salonen-Ros, Elna-Marie Larsson, Santino Gaudio, Samantha J Brooks, Helgi B Schiöth
Few studies have used diffusion tensor imaging (DTI) to investigate the micro-structural alterations of WM in patients with restrictive eating disorders (rED), and longitudinal data are lacking. Twelve patients with rED were scanned at diagnosis and after one year of family-based treatment, and compared to twenty-four healthy controls (HCs) through DTI analysis. A tract-based spatial statistics procedure was used to investigate diffusivity parameters: fractional anisotropy (FA) and mean, radial and axial diffusivities (MD, RD and AD, respectively)...
2017: PloS One
https://www.readbyqxmd.com/read/28229399/neurological-complications-of-the-leukemias-across-the-ages
#5
REVIEW
Stephanie Berg, Sucha Nand
PURPOSE OF REVIEW: Acute and chronic leukemias are heterogeneous diseases and can affect any part of the body upon initial discovery. Understanding the sequela of systemic involvement is key for proper diagnosis and treatment. RECENT FINDINGS: Over the decades, new research has emerged regarding neurological complications of the myeloid or lymphoid leukemias. Central nervous system involvement usually confers a poor prognosis and requires emergent treatment. Standard of care still involves systemic therapy, intrathecal administration of chemotherapeutic agents, and cranial radiation...
February 2017: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/28220892/epigenetic-determinants-of-space-radiation-induced-cognitive-dysfunction
#6
Munjal M Acharya, Al Anoud D Baddour, Takumi Kawashita, Barrett D Allen, Amber R Syage, Thuan H Nguyen, Nicole Yoon, Erich Giedzinski, Liping Yu, Vipan K Parihar, Janet E Baulch
Among the dangers to astronauts engaging in deep space missions such as a Mars expedition is exposure to radiations that put them at risk for severe cognitive dysfunction. These radiation-induced cognitive impairments are accompanied by functional and structural changes including oxidative stress, neuroinflammation, and degradation of neuronal architecture. The molecular mechanisms that dictate CNS function are multifaceted and it is unclear how irradiation induces persistent alterations in the brain. Among those determinants of cognitive function are neuroepigenetic mechanisms that translate radiation responses into altered gene expression and cellular phenotype...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28212704/neurochemical-differences-in-learning-and-memory-paradigms-among-rats-supplemented-with-anthocyanin-rich-blueberry-diets-and-exposed-to-acute-doses-of-56-fe-particles
#7
Shibu M Poulose, Bernard M Rabin, Donna F Bielinski, Megan E Kelly, Marshall G Miller, Nopporn Thanthaeng, Barbara Shukitt-Hale
The protective effects of anthocyanin-rich blueberries (BB) on brain health are well documented and are particularly important under conditions of high oxidative stress, which can lead to "accelerated aging." One such scenario is exposure to space radiation, consisting of high-energy and -charge particles (HZE), which are known to cause cognitive dysfunction and deleterious neurochemical alterations. We recently tested the behavioral and neurochemical effects of acute exposure to HZE particles such as (56)Fe, within 24-48h after exposure, and found that radiation primarily affects memory and not learning...
February 2017: Life Sciences in Space Research
https://www.readbyqxmd.com/read/28187964/brain-perfusion-and-diffusion-abnormalities-in-children-treated-for-posterior-fossa-brain-tumors
#8
Matthew D Li, Nils D Forkert, Palak Kundu, Cheryl Ambler, Robert M Lober, Terry C Burns, Patrick D Barnes, Iris C Gibbs, Gerald A Grant, Paul G Fisher, Samuel H Cheshier, Cynthia J Campen, Michelle Monje, Kristen W Yeom
OBJECTIVE: To compare cerebral perfusion and diffusion in survivors of childhood posterior fossa brain tumor with neurologically normal controls and correlate differences with cognitive dysfunction. STUDY DESIGN: We analyzed retrospectively arterial spin-labeled cerebral blood flow (CBF) and apparent diffusion coefficient (ADC) in 21 patients with medulloblastoma (MB), 18 patients with pilocytic astrocytoma (PA), and 64 neurologically normal children. We generated ANCOVA models to evaluate treatment effects on the cerebral cortex, thalamus, caudate, putamen, globus pallidus, hippocampus, amygdala, nucleus accumbens, and cerebral white matter at time points an average of 5...
February 7, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28182655/regional-analysis-of-volumes-and-reproducibilities-of-automatic-and-manual-hippocampal-segmentations
#9
Fabian Bartel, Hugo Vrenken, Fetsje Bijma, Frederik Barkhof, Marcel van Herk, Jan C de Munck
PURPOSE: Precise and reproducible hippocampus outlining is important to quantify hippocampal atrophy caused by neurodegenerative diseases and to spare the hippocampus in whole brain radiation therapy when performing prophylactic cranial irradiation or treating brain metastases. This study aimed to quantify systematic differences between methods by comparing regional volume and outline reproducibility of manual, FSL-FIRST and FreeSurfer hippocampus segmentations. MATERIALS AND METHODS: This study used a dataset from ADNI (Alzheimer's Disease Neuroimaging Initiative), including 20 healthy controls, 40 patients with mild cognitive impairment (MCI), and 20 patients with Alzheimer's disease (AD)...
2017: PloS One
https://www.readbyqxmd.com/read/28174514/associations-among-cognitive-functions-plasma-dna-and-white-matter-integrity-in-patients-with-early-onset-parkinson-s-disease
#10
Yueh-Sheng Chen, Meng-Hsiang Chen, Cheng-Hsien Lu, Pei-Chin Chen, Hsiu-Ling Chen, I-Hsiao Yang, Nai-Wen Tsai, Wei-Che Lin
Early-onset Parkinson's disease (EOPD) patients are symptomatic at a relatively young age, and the impacts of the disease on both the patients and their caregivers are dramatic. Few studies have reported on the cognitive impairments seen in EOPD, and the results of these studies have been diverse. Furthermore, it is still unclear what microstructural white matter (WM) changes are present in EOPD patients. As such, we conducted this study to investigate the microstructural WM changes experienced by EOPD patients and their association with cognitive function and plasma DNA levels...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28161072/-brain-metastases-focal-treatment-surgery-and-radiation-therapy-and-cognitive-consequences
#11
REVIEW
Emmanuelle Reygagne, Foucaud Du Boisgueheneuc, Antoine Berger
Brain metastases represent the first cause of malignant brain tumor. Without radiation therapy, prognosis was poor with fast neurological deterioration, and a median overall survival of one month. Nowadays, therapeutic options depend on brain metastases presentation, extra brain disease, performance status and estimated prognostic (DS GPA). Therefore, for oligometastatic brain patients with a better prognosis, this therapeutic modality is controversial. In fact, whole-brain radiation therapy improves neurological outcomes, but it can also induce late neuro-cognitive sequelae for long-term survivors of brain metastases...
February 1, 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/28156672/attitude-and-support-to-inform-clinical-predictions-of-survival-in-patients-with-advanced-cancer
#12
David L Ma, Kim Paulson, Sunita Ghosh, Bronwen LeGuerrier, Karen P Chu, Diane Severin, Fleur Huang, Sharon Watanabe, Ann Huot, John Amanie, Samir Patel, Tirath Nijjar, Ericka Wiebe, Brita Lavender Danielson, Brock J Debenham
39 Background: Tumour factors (eg primary site, size) helpful in prognostication in early stage cancer may be less important than patient factors, such as Karnofsky performance status (KPS), later in the disease trajectory. We evaluated the utilization of the parameters attitude (ATT) and psychosocial support (PSS) in predicting remaining lifespan by two experienced multidisciplinary teams (MDT). METHODS: After clinical assessment of consecutive patients, a quantitative clinical prediction of survival (CPS) was made prospectively, independently and anonymously by each health care provider (HCP)...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28156212/changes-in-the-hippocampal-proteome-associated-with-spatial-memory-impairment-after-exposure-to-low-20-cgy-doses-of-1-gev-n-56-fe-radiation
#13
Richard A Britten, Jessica S Jewell, Leslie K Davis, Vania D Miller, Melissa M Hadley, O John Semmes, György Lonart, Sucharita M Dutta
Exposure to low (∼20 cGy) doses of high-energy charged(HZE) particles, such as 1 GeV/n (56)Fe, results in impaired hippocampal-dependent learning and memory (e.g., novel object recognition and spatial memory) in rodents. While these findings raise the possibility that astronauts on deep-space missions may develop cognitive deficits, not all rats develop HZE-induced cognitive impairments, even after exposure to high (200 cGy) HZE doses. The reasons for this differential sensitivity in some animals that develop HZE-induced cognitive failure remain speculative...
February 3, 2017: Radiation Research
https://www.readbyqxmd.com/read/28156177/abnormalities-in-hippocampal-volume-of-glioma-patients-prior-to-radiotherapy
#14
Roshan A Karunamuni, Tyler M Seibert, Nathan S White, Linda McEvoy, Nikdokht Farid, James Brewer, Anders M Dale, Carrie R McDonald, Jona A Hattangadi-Gluth
BACKGROUND: Radiation-induced cognitive impairment may be mediated by hippocampal damage, but the structural integrity of this region in tumor patients at baseline is unclear. Hippocampal volumes of 31 glioma patients prior to receiving radiotherapy were compared to a group of 34 healthy controls. MATERIALS AND METHODS: Left and right hippocampi on T1-weighted pre-contrast magnetic resonance images were automatically segmented using Freesurfer, and visually inspected for segmentation errors...
March 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28125924/performance-based-and-parent-ratings-of-attention-in-children-treated-for-a-brain-tumor-the-significance-of-radiation-therapy-and-tumor-location-on-outcome
#15
Kimberly P Raghubar, E Mark Mahone, Keith Owen Yeates, M Douglas Ris
Children are at increased risk for cognitive difficulties following the diagnosis and treatment of a brain tumor. Radiation therapy (RT) and tumor location are commonly-cited predictors of neurocognitive functioning. Disruptions to foundational neurocognitive processes such as attention, working memory, and processing speed underlie declines on measures of general intellectual functioning. While several studies have examined visual sustained attention in pediatric brain tumor patients, auditory sustained attention has yet to be examined...
January 26, 2017: Child Neuropsychology: a Journal on Normal and Abnormal Development in Childhood and Adolescence
https://www.readbyqxmd.com/read/28115194/the-brain-map-of-gait-variability-in-aging-cognitive-impairment-and-dementia-a-systematic-review
#16
REVIEW
Qu Tian, Nathalie Chastan, Woei-Nan Bair, Susan M Resnick, Luigi Ferrucci, Stephanie A Studenski
While gait variability may reflect subtle changes due to aging or cognitive impairment (CI), associated brain characteristics remain unclear. We summarize structural and functional neuroimaging findings associated with gait variability in older adults with and without CI and dementia. We identified 17 eligible studies; all were cross-sectional; few examined multiple brain areas. In older adults, temporal gait variability was associated with structural differences in medial areas important for lower limb coordination and balance...
March 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28108320/modulation-on-brain-gray-matter-activity-and-white-matter-integrity-by-apoe-%C3%AE%C2%B54-risk-gene-in-cognitively-intact-elderly-a-multimodal-neuroimaging-study
#17
Suping Cai, Yuanyuan Jiang, Yubo Wang, Xiaoming Wu, Junchan Ren, Min Seob Lee, Sunghoon Lee, Liyu Huang
Apolipoprotein E (APOE) ε4 allele is the genetic risk factor with the most established evidence for sporadic Alzheimer's disease. Previous neuroimaging studies have demonstrated insufficiently consistent functional and structural changes among healthy APOE ε4 carriers when compared to non-carriers. Here, in a cognitively intact elderly group (a total of 110: 45 APOE ε4 carriers, 65 non-carriers), we aimed to investigate the potential role of APOE ε4 in the modulation of grey matter activity, white matter integrity, and brain morphology before the development of clinically significant symptoms and signs, by methods of: amplitude of low frequency fluctuations and regional homogeneity analysis based on resting state fMRI, and fiber tractography approach based on diffusion tensor imaging...
January 17, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28107493/white-matter-abnormalities-in-two-different-subtypes-of-amnestic-mild-cognitive-impairment
#18
Jianghong Liu, Peipeng Liang, Linlin Yin, Ni Shu, Tengda Zhao, Yi Xing, Fangyu Li, Zhilian Zhao, Kuncheng Li, Ying Han
White matter (WM) degeneration has been found during the course of cognitive decline in both Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI), however, it is unclear whether there are different WM microstructural abnormalities between two subtypes of aMCI, including single domain aMCI (aMCI-s) and multiple domain aMCI (aMCI-m). Thirty-two patients of aMCI single-domain (aMCI-s), twenty-three patients of aMCI multiple-domain (aMCI-m) and twenty-three healthy normal controls (NC) participated in this study...
2017: PloS One
https://www.readbyqxmd.com/read/28099397/the-effects-of-attention-problems-on-psychosocial-functioning-in-childhood-brain-tumor-survivors-a-2-year-postcraniospinal-irradiation-follow-up
#19
Yunhye Oh, Hyunjung Seo, Ki Woong Sung, Yoo Sook Joung
OBJECTIVE: To examine the psychosocial outcomes and impact of attention problems in survivors of pediatric brain tumor. STUDY DESIGN: The survivors' cognitive functioning was measured using the Wechsler Intelligence Scale for Children. The Child Behavior Checklist-Attention Problems scale was used to screen for attention problems, and participants were classified as having attention problems (n=15) or normal attention (n=36). Psychosocial functioning was examined with the Korean Personality Rating scale for Children (K-PRC) at precraniospinal radiation and at 2-year follow-up...
March 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28093012/male-coping-through-a-long-term-cancer-trajectory-secondary-outcomes-from-a-rtc-examining-the-effect-of-a-multidisciplinary-rehabilitation-program-repca-among-radiated-men-with-prostate-cancer
#20
RANDOMIZED CONTROLLED TRIAL
Karin B Dieperink, Christoffer Johansen, Steinbjørn Hansen, Lis Wagner, Klaus K Andersen, Lisbeth R Minet, Olfred Hansen
BACKGROUND: The objective of this study was to examine if rehabilitation influenced self-reported male coping styles during and up to three years after treatment with radiotherapy for prostate cancer. MATERIALS AND METHODS: In a single-center oncology unit in Odense, Denmark, 161 prostate cancer patients treated with radiotherapy and androgen deprivation therapy were included in a randomized controlled trial from 2010 to 2012. The trial examined the effect of a multidisciplinary rehabilitation program within six months of treatment consisting of two nursing counseling sessions and two instructive sessions with a physical therapist (n = 79), or standard care (n = 82)...
February 2017: Acta Oncologica
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