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radiation cognition

H-J Kim, S-I Oh, M de Leon, X Wang, K-W Oh, J-S Park, A Deshpande, M Buj, S H Kim
BACKGROUND AND PURPOSE: Amyotrophic lateral sclerosis (ALS), a motor neuron disease, is associated with various cortical symptoms including mild cognitive decline with behavior changes, suggesting the involvement of extra-motor areas in ALS. Our aim was to investigate the specific patterns of brain atrophy in sporadic, impaired ALS patients without commonly known genetic mutations using voxel-based morphometry. MATERIALS AND METHODS: Forty-seven patients with sporadic ALS and 28 age-matched healthy controls were recruited...
October 18, 2016: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
RaviK Shastri, GaurangV Shah, Page Wang, Patricia Cagnoli, Tobias Schmidt-Wilcke, Joseph McCune, Richard Harris, PiaC Sundgren
PURPOSE: Systemic lupus erythematosus (SLE) is a predominantly female autoimmune disease that can affect the central nervous system. Neuropsychiatric symptoms are found in 25-70% of SLE patients. Using diffusion tensor imaging, various studies have reported changes in white matter integrity in SLE patients with neuropsychiatric symptoms (NPSLE patients). The purpose of this study was to investigate if changes can be detected in the individual white matter tracts in SLE patients regardless if neuropsychiatric symptoms are present or not...
October 13, 2016: Academic Radiology
David B Hanbury, Ann M Peiffer, Greg Dugan, Rachel N Andrews, J Mark Cline
In this study, the effects of a potentially lethal radiation exposure on the brain for long-term cognitive sequelae were investigated, using Rhesus macaques ( Macaca mulatta ) adopted from other facilities after analysis of acute radiation response via the Centers for Medical Countermeasures against Radiation (CMCR) network. Fifty-nine animals were given the opportunity to participate in cognitive cage-side testing. The animals that received single-dose gamma irradiation were significantly less likely to engage in cognitive testing than the controls, suggesting that irradiated animals may have differences in cognitive ability...
October 14, 2016: Radiation Research
Ute Berndt, Bernd Leplow, Robby Schoenfeld, Tilmann Lantzsch, Regina Grosse, Christoph Thomssen
INTRODUCTION: It is generally accepted that estrogens play a protective role in cognitive function. Therefore, it can be expected that subtotal estrogen deprivation following aromatase inhibition will alter cognitive performance. METHODS: In a cross-sectional study we investigated 80 postmenopausal women with breast cancer. Memory and spatial cognition were compared across 4 treatment groups: tamoxifen only (TAM, n = 22), aromatase inhibitor only (AI, n = 22), TAM followed by AI ('SWITCH group', n = 15), and patients with local therapy (LT) only (surgery and radiation, n = 21)...
August 2016: Breast Care
Vipan K Parihar, Barrett D Allen, Chongshan Caressi, Stephanie Kwok, Esther Chu, Katherine K Tran, Nicole N Chmielewski, Erich Giedzinski, Munjal M Acharya, Richard A Britten, Janet E Baulch, Charles L Limoli
The Mars mission will result in an inevitable exposure to cosmic radiation that has been shown to cause cognitive impairments in rodent models, and possibly in astronauts engaged in deep space travel. Of particular concern is the potential for cosmic radiation exposure to compromise critical decision making during normal operations or under emergency conditions in deep space. Rodents exposed to cosmic radiation exhibit persistent hippocampal and cortical based performance decrements using six independent behavioral tasks administered between separate cohorts 12 and 24 weeks after irradiation...
October 10, 2016: Scientific Reports
Hee Jung Yoo, Hyery Kim, Hyeon Jin Park, Dong Seok Kim, Young Shin Ra, Hee Young Shin
The neurocognitive function and quality of life of 58 Korean survivors of childhood medulloblastoma were assessed after surgery, cranial radiation and chemotherapy. All patients were evaluated with a battery of neurocognitive function tests and the Pediatric Functional Assessment of Cancer Therapy-Brain Tumor Survivors, which consists of self-report questionnaires on quality of life. The mean full-scale intelligence quotient (IQ), verbal IQ, and performance IQ scores were 90.2, 97.1, and 84.16, respectively...
November 2016: Journal of Korean Medical Science
Caitlin Feiock, Masashi Yagi, Adam Maidman, Aaron Rendahl, Susanta Hui, Davis Seelig
The unintended side effects of cancer treatment are increasing recognized. Among these is a syndrome of long-term neurocognitive dysfunction called cancer/chemotherapy related cognitive impairment. To date, all studies examining the cognitive impact of cancer treatment have emphasized chemotherapy. Radiation-induced bystander effects have been described in cell culture and, to a limited extent, in rodent model systems. The purpose of this study was to examine, for the first time, the impact of non-brain directed radiation therapy on the brain in order to elucidate its potential relationship with cancer/chemotherapy related cognitive impairment...
2016: PloS One
J van Duijnhoven, M P J Aarts, M B C Aries, M N Böhmer, A L P Rosemann
BACKGROUND: The non-image-forming effects of luminous radiation on people with intellectual disabilities or dementia received attention from researchers. Such studies, however, have generally been conducted using disparate methodologies which precludes generalization and reproducibility. OBJECTIVE: The aim of this study was to determine the practical applicability of measurement devices for studies investigating non-image-forming effects of luminous radiation, specifically for people with intellectual disabilities or dementia...
September 20, 2016: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
Paul E Wallner, Anthony Gerdeman, Jennifer M Willis, Anthony L Zietman
Based on data obtained from clinical practice analysis (CPA) surveys performed in 2010 and 2013, and with input from its maintenance of certification (MOC) advisory committee, the American Board of Radiology (ABR) recognized that the changing nature of radiation oncology practice patterns warranted revisions of its MOC Part III cognitive examination. One significant revision was the introduction of a modular examination that allowed diplomates to select specific areas of clinical interest. The module-based items represented 30% (60 of 200) of total examination content...
May 7, 2016: Practical Radiation Oncology
C Okoukoni, E McTyre, A M Peiffer, W Hinson, R E Strowd, S Rapp, M D Chan
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
M Zhou, L Zou, Q Q Chen, Y Tian, Y X Lian
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
N Alphonse Sullivan, B R Page, A M Peiffer, S Isom, L Metheny-Barlow, D R Brown, A W Blackstock, M D Chan
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
M Xu, Y Chen, Q Zhang, J Zhang, H Wu, Y Tian
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
L E Beaton, R Ma, F Hsu, L Gondara, H Carolan, R A Olson, D Schellenberg, F Germain, A K Cheung, M McKenzie, A Nichol
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
K S Kim, C W Wee, J Y Seok, J Hong, J B Chung, K Y Eom, J S Kim, C Y Kim, Y H Park, Y J Kim, I A Kim
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Alan Kiang, Vivian K Weinberg, Ka Ho Nicholas Cheung, Erin Shugard, Josephine Chen, Jeanne M Quivey, Sue S Yom
BACKGROUND: There is a lack of data on quality of life in long-term survivors of nasopharyngeal carcinoma (NPC) who have been treated with intensity-modulated radiation therapy (IMRT). We characterized long-term disease-specific and cognitive QoL in NPC survivors after IMRT. METHODS: We conducted a cross-sectional study of surviving patients diagnosed and treated for NPC at our center with curative-intent IMRT, with or without chemotherapy. Patients who were deceased, still undergoing treatment, with known recurrent disease, or treated with RT modality other than IMRT were excluded...
2016: Radiation Oncology
Richard A Britten, Vania D Miller, Melissa M Hadley, Jessica S Jewell, Evangeline Macadat
NASA is currently conducting ground based experiments to determine whether the radiation environment that astronauts will encounter on deep space missions will have an impact on their long-term health and their ability to complete the various tasks during the mission. Emerging data suggest that exposure of rodents to mission-relevant HZE radiation doses does result in the impairment of various neurocognitive processes. An essential part of mission planning is a probabilistic risk assessment process that takes into account the likely incidence and severity of a problem...
August 2016: Life Sciences in Space Research
Yin Ting Cheung, Noah D Sabin, Wilburn E Reddick, Deepa Bhojwani, Wei Liu, Tara M Brinkman, John O Glass, Scott N Hwang, Deokumar Srivastava, Ching-Hon Pui, Leslie L Robison, Melissa M Hudson, Kevin R Krull
BACKGROUND: Leukoencephalopathy is observed in some children undergoing chemotherapy for acute lymphoblastic leukaemia, although its effects on long-term outcomes is unknown. This study examines the associations between acute leukoencephalopathy and neurobehavioural, neurocognitive, and brain white matter imaging outcomes in long-term survivors of childhood acute lymphoblastic leukaemia treated with chemotherapy without cranial radiation. METHODS: In this longitudinal analysis, we used data of children with acute lymphoblastic leukaemia at St Jude Children's Research Hospital (Memphis, TN, USA) who had been treated between June 1, 2000, and Oct 31, 2010...
October 2016: Lancet Haematology
Vyshak Alva Venur, José Pablo Leone
The discovery of various driver pathways and targeted small molecule agents/antibodies have revolutionized the management of metastatic breast cancer. Currently, the major targets of clinical utility in breast cancer include the human epidermal growth factor receptor 2 (HER2) and epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF) receptor, mechanistic target of rapamycin (mTOR) pathway, and the cyclin-dependent kinase 4/6 (CDK-4/6) pathway. Brain metastasis, however, remains a thorn in the flesh, leading to morbidity, neuro-cognitive decline, and interruptions in the management of systemic disease...
September 13, 2016: International Journal of Molecular Sciences
Lisa M Jacola, Kim Edelstein, Wei Liu, Ching-Hon Pui, Robert Hayashi, Nina S Kadan-Lottick, Deokumar Srivastava, Tara Henderson, Wendy Leisenring, Leslie L Robison, Gregory T Armstrong, Kevin R Krull
BACKGROUND: Survivors of childhood acute lymphoblastic leukaemia (ALL) are at risk for neurocognitive deficits that affect development in adolescence and young adulthood, and influence educational attainment and future independence. We examined a large and diverse cohort of survivors to identify risk predictors and modifiers of these outcomes. METHODS: In this cohort study, cognitive and behaviour symptoms were assessed via a standardised parent questionnaire for 1560 adolescent survivors of ALL diagnosed between 1970 and 1999...
October 2016: Lancet Psychiatry
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