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acute asthma adult

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https://www.readbyqxmd.com/read/29877740/between-visit-variability-in-fev-1-as-a-diagnostic-test-for-asthma-in-adults
#1
Benjamin W Dean, Erin E Birnie, G A Whitmore, Katherine L Vandemheen, Louis-Philippe Boulet, J Mark FitzGerald, Martha Ainslie, Samir Gupta, Catherine Lemiere, Stephen K Field, R Andrew McIvor, Paul Hernandez, Irvin Mayers, Shawn D Aaron
RATIONALE: The reliability of using between-visit variation in FEV1 to diagnose asthma is understudied, and hence uncertain. OBJECTIVE: To determine if FEV1 variability measured over recurrent visits is significantly associated with a diagnosis of current asthma. METHODS: Randomly-selected adults (N=964) with a history of physician-diagnosed asthma were studied from 2005-2007 and from 2012-2016. A diagnosis of current asthma was confirmed in those participants who exhibited bronchial hyper-responsiveness to methacholine and/or acute worsening of asthma symptoms while being weaned off asthma medications...
June 7, 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29859017/intramuscular-versus-oral-corticosteroids-to-reduce-relapses-following-discharge-from-the-emergency-department-for-acute-asthma
#2
REVIEW
Scott W Kirkland, Elfriede Cross, Sandra Campbell, Cristina Villa-Roel, Brian H Rowe
BACKGROUND: Acute asthma is a common cause of presentations to acute care centres, such as the emergency department (ED), and while the majority of patients can be discharged, relapse requiring additional medical care is common. Systemic corticosteroids are a major part in the treatment of moderate to severe acute asthma; however, there is no clear evidence regarding the most effective route of administration for improving outcomes in patients discharged from acute care. OBJECTIVES: To examine the effectiveness and safety of a single dose of intramuscular (IM) corticosteroids provided prior to discharge compared to a short course of oral corticosteroids in the treatment of acute asthma patients discharged from an ED or equivalent acute care setting...
June 2, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29800768/short-term-effects-of-airport-associated-ultrafine-particle-exposure-on-lung-function-and-inflammation-in-adults-with-asthma
#3
Rima Habre, Hui Zhou, Sandrah P Eckel, Temuulen Enebish, Scott Fruin, Theresa Bastain, Edward Rappaport, Frank Gilliland
BACKGROUND: Exposure to ultrafine particles (UFP, particles with aerodynamic diameter < 100 nm) is associated with reduced lung function and airway inflammation in individuals with asthma. Recently, elevated UFP number concentrations (PN) from aircraft landing and takeoff activity were identified downwind of the Los Angeles International Airport (LAX) but little is known about the health impacts of airport-related UFP exposure. METHODS: We conducted a randomized crossover study of 22 non-smoking adults with mild to moderate asthma in Nov-Dec 2014 and May-Jul 2015 to investigate short-term effects of exposure to LAX airport-related UFPs...
May 22, 2018: Environment International
https://www.readbyqxmd.com/read/29780025/neighbourhood-socioeconomic-position-and-risks-of-major-chronic-diseases-and-all-cause-mortality-a-quasi-experimental-study
#4
Daniel Kim, Richard H Glazier, Brandon Zagorski, Ichiro Kawachi, Philip Oreopoulos
OBJECTIVES: This study estimated the health impacts of neighbourhood socioeconomic position (SEP) among public housing residents. Because applicants to public housing were assigned to housing projects primarily based on factors other than personal choice, we capitalised on a quasirandom source of variation in neighbourhood of residence to obtain more valid estimates of the health impacts of neighbourhood SEP. DESIGN: Quasiexperimental study. SETTING: Greater Metropolitan Toronto area, Canada...
May 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29755346/a-multicenter-randomized-double-blind-placebo-controlled-study-of-the-effects-of-loki-zupa-in-patients-with-chronic-asthma
#5
Yubao Lv, Ying Wei, Muhammadjan Abduwaki, Tohti Jurat, Fengsen Li, Huaizhen Wang, Yuhua Wu, Zheng Li, Bo Liu, Hongjun Yin, Yuxue Cao, Mammat Nurahmat, Zihui Tang, Jingcheng Dong
The purpose of this study was to evaluate the efficacy and safety of Uyghur medical formula Loki zupa in patients with chronic asthma. Adult patients with chronic asthma randomly received placebo or Loki zupa as add-on to inhaled corticosteroids (ICS) maintenance treatment. Loki zupa or mimics was administered orally 10 ml per time, three times a day for 8 weeks. The primary endpoints were asthma control test (ACT) score and peak expiratory flow (PEF). The secondary endpoints were acute exacerbation rate, lung function, night waking days, and symptom-free days in the near 2 weeks, Asthma Quality of Life Questionnaire (AQLQ) score and some inflammatory cytokines in peripheral blood...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29738108/causes-of-shortness-of-breath-in-the-acute-patient-a-national-study
#6
Zachariah E Hale, Astha Singhal, Renee Y Hsia
BACKGROUND: Dyspnea is a common and ambiguous complaint that results in 3.4 million emergency department visits annually. While learners may encounter lists of differential diagnoses to consider while in training, often these lists are not empirically based. We sought to establish an evidence-based differential diagnosis for dyspnea and to determine whether normal vital signs can rule out a life-threatening diagnosis. METHODS: We analyzed data from the National Hospital Ambulatory Medical Care Survey from 2005-2014 for emergency department visits with a chief complaint of dyspnea and tallied the principal discharge diagnosis...
May 8, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29731926/practical-approach-to-lung-health-experience-from-the-republic-of-macedonia
#7
Biljana Ilievska-Poposka, Maja Zakoska, Stefan Talevski
BACKGROUND: Among the adults and children aged 5 yrs who attend PHC settings, 20-30% seeks to care for respiratory symptoms. Over 80-90% of the respiratory patients suffer from acute respiratory infections (ARI), followed by chronic obstructive pulmonary diseases (COPD), asthma, and less frequently with pneumonia and tuberculosis (TB). To improve the quality of care in patients who seek assistance for respiratory symptoms in PHC settings and the efficiency of respiratory service delivery within healthcare systems, WHO has designated several initiatives among which one is PAL (Practical Approach to Lung Health)...
April 15, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29724395/asthma-control-in-adults-in-the-middle-east-and-north-africa-results-from-the-esmaa-study
#8
Hesham Tarraf, Hamdan Al-Jahdali, Abdul Hameed Al Qaseer, Anamarija Gjurovic, Houria Haouichat, Basheer Khassawneh, Bassam Mahboub, Roozbeh Naghshin, François Montestruc, Naser Behbehani
BACKGROUND: Low levels of asthma control are reported in many countries worldwide. Improved knowledge of asthma control in the Middle East and Africa and predictive factors is needed to address this major public healthcare burden. OBJECTIVE: To assess the level of asthma control in patients attending a routine consultation for asthma in the Middle East and North Africa, and the relationship between level of control and patient and disease characteristics, adherence, and quality of life (QoL)...
May 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29712621/incidence-of-lower-respiratory-tract-infections-and-atopic-conditions-in-boys-and-young-male-adults-royal-college-of-general-practitioners-research-and-surveillance-centre-annual-report-2015-2016
#9
Simon de Lusignan, Ana Correa, Richard Pebody, Ivelina Yonova, Gillian Smith, Rachel Byford, Sameera Rankiri Pathirannehelage, Christopher McGee, Alex J Elliot, Mariya Hriskova, Filipa Im Ferreira, Imran Rafi, Simon Jones
BACKGROUND: The Royal College of General Practitioners Research and Surveillance Centre comprises more than 150 general practices, with a combined population of more than 1.5 million, contributing to UK and European public health surveillance and research. OBJECTIVE: The aim of this paper was to report gender differences in the presentation of infectious and respiratory conditions in children and young adults. METHODS: Disease incidence data were used to test the hypothesis that boys up to puberty present more with lower respiratory tract infection (LRTI) and asthma...
April 30, 2018: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/29676619/cysteinyl-leukotriene-receptor-1-and-health-effects-of-particulate-exposure-in-asthma
#10
Nathan Rabinovitch, Meaghan J Jones, Anna Faino, Matthew Strand, Alexander M Morin, Julia MacIsaac, Paul R Reynolds, Amrit Singh, Michael S Kobor, Erwin W Gelfand, Christopher Carlsten
RATIONALE: Acute exposure to ambient particle matter is associated with increased levels of the cysteinyl leukotriene (CysLT) biomarker, urinary leukotriene E4 (uLTE4 ), in subjects with asthma. OBJECTIVES: The role of CysLTs in mediating asthma worsening after particulate matter exposures was explored. METHODS: Daily concentrations of particulate matter of 2.5 μm and smaller diameter (PM2.5 ) and repeated measurements of albuterol use over a 5-month period were collected in 44 urban school children with persistent asthma...
April 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29653218/comparing-ran-out-status-of-inhaled-short-acting-beta-agonists-in-emergency-department-patients-with-acute-asthma-1996-1998-versus-2015-2017
#11
Tadahiro Goto, Carlos A Camargo, Catalina Gimenez-Zapiola, Daniel J Pallin, Nathan I Shapiro, Thomas J Ferro, Carolyn Rainville, Stanislav Stoyanov, Kohei Hasegawa
BACKGROUND: Medication nonadherence, including running out of inhaled asthma medications, is an important problem. OBJECTIVE: The objective of this study was to examine the changes in the proportion of adults with acute asthma who ran out of their short-acting beta-agonist (SABA) inhalers before presenting to the emergency department (ED) between 1996--1998 and 2015-2017. METHODS: We analyzed data from prospective multicenter observational cohort studies of ED adult patients (aged 18-54 years) with acute asthma...
April 11, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29562641/estimating-the-burden-of-serious-fungal-infections-in-uruguay
#12
Marina Macedo-Viñas, David W Denning
We aimed to estimate for the first time the burden of fungal infections in Uruguay. Data on population characteristics and underlying conditions were extracted from the National Statistics Institute, the World Bank, national registries, and published articles. When no data existed, risk populations were used to estimate frequencies extrapolating from the literature. Population structure (inhabitants): total 3,444,006; 73% adults; 35% women younger than 50 years. Size of populations at risk (total cases per year): HIV infected 12,000; acute myeloid leukemia 126; hematopoietic stem cell transplantation 30; solid organ transplants 134; COPD 272,006; asthma in adults 223,431; cystic fibrosis in adults 48; tuberculosis 613; lung cancer 1400...
March 18, 2018: Journal of Fungi (Basel, Switzerland)
https://www.readbyqxmd.com/read/29521552/factors-associated-with-hospital-admission-in-adult-patients-with-asthma-exacerbations-a-systematic-review
#13
Nicholas Arrotta, Jesse Hill, Cristina Villa-Roel, Elizabeth Dennett, Molly Harries, Brian H Rowe
OBJECTIVES: A variable proportion of patients presenting to the emergency department (ED) with acute asthma require admission to hospital. Previous studies have identified select factors associated with admission following ED presentation; however, no review has synthesized the evidence in this regard. This systematic review summarizes the evidence regarding factors associated with hospital admission following ED presentation. METHODS: Searches were conducted in seven electronic databases and common sources of grey literature...
March 9, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29518045/an-estimate-of-severe-and-chronic-fungal-diseases-in-the-republic-of-kazakhstan
#14
Vadim M Kemaykin, Nariman B Tabinbaev, Mahira S Khudaibergenova, Anastasia A Olifirovich, Layzzat M Abdrakhmanova, David W Denning, Nikolai Klimko
Our work aimed to generate a preliminary estimation of severe and chronic fungal diseases in the Republic of Kazakhstan with a model proposed by LIFE (Leading International Fungal Education). Calculations were carried out on data from 2015. Published results of studies of mycoses in Kazakhstan were identified; in the absence of national data from the scientific literature, the frequency of life-threatening and serious mycoses in defined groups of patients at risk from other countries were taken into account...
March 8, 2018: Journal of Fungi (Basel, Switzerland)
https://www.readbyqxmd.com/read/29486764/impaired-type-i-interferon-regulation-in-the-blood-transcriptome-of-recurrent-asthma-exacerbations
#15
Jose L Gomez, Maria P Diaz, Gustavo Nino, Clemente J Britto
BACKGROUND: Asthma exacerbations are an important cause of morbidity in asthma. Respiratory infections are often involved in asthma exacerbations in both children and adults. Some individuals with asthma have increased susceptibility to viral infections and as a result increased rates of asthma exacerbations. We sought to identify a transcriptomic signature in the blood associated with asthma exacerbations triggered by respiratory infections (AETRI) and determine its association with increased risk for asthma exacerbations...
February 27, 2018: BMC Medical Genomics
https://www.readbyqxmd.com/read/29477568/asthma-phenotypes-defined-from-parameters-obtained-during-recovery-from-a-hospital-treated-exacerbation
#16
Rihuang Qiu, Jiaxing Xie, Kian Fan Chung, Naijian Li, Zhaowei Yang, Mengzhang He, Jing Li, Rongchang Chen, Nanshan Zhong, Qingling Zhang
BACKGROUND: Asthma is a heterogeneous disease with diverse clinical manifestations and inflammatory pathologies that is punctuated by exacerbations. OBJECTIVE: To describe the clinical and inflammatory characteristics of patients with asthma treated in hospital for an acute exacerbation. METHODS: Data from 320 adult patients receiving treatment for an acute exacerbation of asthma were obtained. In 218 patients with complete data, we used the Ward hierarchical clustering to obtain clusters...
March 1, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29469993/asthma-among-adult-patients-presenting-with-dyspnea-to-the-emergency-department-an-observational-study
#17
Win Sen Kuan, Simon Craig, Anne-Maree Kelly, Gerben Keijzers, Sharon Klim, Colin A Graham, Peter Jones, Anna Holdgate, Charles Lawoko, Said Laribi
INTRODUCTION: Shortness of breath is a common presenting symptom to the emergency department (ED) that can arise from a myriad of possible diagnoses. Asthma is one of the major causes. OBJECTIVE: The aim of this study was to describe the demographic features, clinical characteristics, management and outcomes of adults with an ED diagnosis of asthma who presented to an ED in the Asia Pacific region with a principal symptom of dyspnea. METHODS: Planned sub-study of patients with an ED diagnosis of asthma identified in the Asia, Australia and New Zealand Dyspnoea in Emergency Departments (AANZDEM) study...
February 22, 2018: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29460272/hyperglycemia-in-children-hospitalized-with-acute-asthma
#18
Khalid F Mobaireek, Abdulrahman Alshehri, Abdulaziz Alsadoun, Abdullah Alasmari, Abdullah Alashhab, Meshal Alrumaih, Mohammad Alothman, Abdullah A Alangari
Hyperglycemia is frequently observed in adults with acute asthma. We aimed to assess the frequency of hyperglycemia and its relation to outcomes in children admitted with acute asthma. In this retrospective study, we reviewed medical records of non-diabetic 166 children (66 girls) with the mean age of 5.4 ± 2.6 years (range of 2-12 years), who were hospitalized with acute asthma between January 2012 through December 2014. Data pertaining to demographics, vital signs, oxygen saturation, serum blood glucose level, electrolytes, blood gases, and admission were collected...
February 20, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29452277/association-between-obesity-and-acute-severity-among-patients-hospitalized-for-asthma-exacerbation
#19
Sarah Kyuragi Luthe, Atsushi Hirayama, Tadahiro Goto, Mohammad Kamal Faridi, Carlos A Camargo, Kohei Hasegawa
BACKGROUND: Although studies have demonstrated relations between obesity and incident asthma, little is known about the association of obesity with acute severity in adults hospitalized for asthma exacerbation. OBJECTIVES: To investigate the association of obesity with acute severity of asthma exacerbation. METHODS: This is a retrospective cohort study using population-based data of 8 geographically diverse US states from 2010 through 2013...
February 14, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29420096/gamma-globulin-replacement-therapy-in-uncontrolled-severe-asthma-associated-with-humoral-immunodeficiency-a-series-of-five-case-reports
#20
Angelica Tiotiu, Yves Martinet, Roger Jankowski, Philippe Devillier
We report on five adult cases of the rare association of asthma with humoral immunodeficiency (huID). All patients had uncontrolled asthma related to recurrent respiratory infections. Asthma was diagnosed according to the Global Initiative for Asthma (GINA) guidelines, and bronchiectasis was ruled out by a CT chest scan. Two men (aged 28 and 60) presented with pollen allergies, chronic rhinosinusitis, and IgG deficiency (7.8 and 7.6 g/L, respectively). Both patients underwent surgery for nasal polyposis but relapsed with acute sinusitis and severe asthma exacerbations requiring treatment with oral corticosteroids and antibiotics...
February 8, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
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