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https://www.readbyqxmd.com/read/29676619/cysteinyl-leukotriene-receptor-1-and-health-effects-of-particulate-exposure-in-asthma
#1
Nathan Rabinovitch, Meaghan J Jones, Anna Faino, Matthew Strand, Alexander M Morin, Julia MacIsaac, Paul R Reynolds, Amrit Singh, Michael S Kobor, Erwin W Gelfand, Christopher Carlsten
RATIONALE: Acute exposure to ambient particle matter is associated with increased levels of the cysteinyl leukotriene (CysLT) biomarker, urinary leukotriene E4 (uLTE4 ), in subjects with asthma. OBJECTIVES: The role of CysLTs in mediating asthma worsening after particulate matter exposures was explored. METHODS: Daily concentrations of particulate matter of 2.5 μm and smaller diameter (PM2.5 ) and repeated measurements of albuterol use over a 5-month period were collected in 44 urban school children with persistent asthma...
April 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29653218/comparing-ran-out-status-of-inhaled-short-acting-beta-agonists-in-emergency-department-patients-with-acute-asthma-1996-1998-versus-2015-2017
#2
Tadahiro Goto, Carlos A Camargo, Catalina Gimenez-Zapiola, Daniel J Pallin, Nathan I Shapiro, Thomas J Ferro, Carolyn Rainville, Stanislav Stoyanov, Kohei Hasegawa
BACKGROUND: Medication non-adherence including running out of inhaled asthma medications, is an important problem. OBJECTIVE: To examine the changes in the proportion of adults with acute asthma who ran out of their short-acting beta-agonist (SABA) inhalers before presenting to the emergency department (ED) between 1996-1998 and 2015-2017. METHODS: We analyzed data from prospective multicenter observational cohort studies of ED adult patients (aged 18-54 years) with acute asthma...
April 10, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29562641/estimating-the-burden-of-serious-fungal-infections-in-uruguay
#3
Marina Macedo-Viñas, David W Denning
We aimed to estimate for the first time the burden of fungal infections in Uruguay. Data on population characteristics and underlying conditions were extracted from the National Statistics Institute, the World Bank, national registries, and published articles. When no data existed, risk populations were used to estimate frequencies extrapolating from the literature. Population structure (inhabitants): total 3,444,006; 73% adults; 35% women younger than 50 years. Size of populations at risk (total cases per year): HIV infected 12,000; acute myeloid leukemia 126; hematopoietic stem cell transplantation 30; solid organ transplants 134; COPD 272,006; asthma in adults 223,431; cystic fibrosis in adults 48; tuberculosis 613; lung cancer 1400...
March 18, 2018: Journal of Fungi (Basel, Switzerland)
https://www.readbyqxmd.com/read/29521552/factors-associated-with-hospital-admission-in-adult-patients-with-asthma-exacerbations-a-systematic-review
#4
Nicholas Arrotta, Jesse Hill, Cristina Villa-Roel, Elizabeth Dennett, Molly Harries, Brian H Rowe
OBJECTIVES: A variable proportion of patients presenting to the emergency department (ED) with acute asthma require admission to hospital. Previous studies have identified select factors associated with admission following ED presentation; however, no review has synthesized the evidence in this regard. This systematic review summarizes the evidence regarding factors associated with hospital admission following ED presentation. METHODS: Searches were conducted in seven electronic databases and common sources of grey literature...
March 9, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29518045/an-estimate-of-severe-and-chronic-fungal-diseases-in-the-republic-of-kazakhstan
#5
Vadim M Kemaykin, Nariman B Tabinbaev, Mahira S Khudaibergenova, Anastasia A Olifirovich, Layzzat M Abdrakhmanova, David W Denning, Nikolai Klimko
Our work aimed to generate a preliminary estimation of severe and chronic fungal diseases in the Republic of Kazakhstan with a model proposed by LIFE (Leading International Fungal Education). Calculations were carried out on data from 2015. Published results of studies of mycoses in Kazakhstan were identified; in the absence of national data from the scientific literature, the frequency of life-threatening and serious mycoses in defined groups of patients at risk from other countries were taken into account...
March 8, 2018: Journal of Fungi (Basel, Switzerland)
https://www.readbyqxmd.com/read/29486764/impaired-type-i-interferon-regulation-in-the-blood-transcriptome-of-recurrent-asthma-exacerbations
#6
Jose L Gomez, Maria P Diaz, Gustavo Nino, Clemente J Britto
BACKGROUND: Asthma exacerbations are an important cause of morbidity in asthma. Respiratory infections are often involved in asthma exacerbations in both children and adults. Some individuals with asthma have increased susceptibility to viral infections and as a result increased rates of asthma exacerbations. We sought to identify a transcriptomic signature in the blood associated with asthma exacerbations triggered by respiratory infections (AETRI) and determine its association with increased risk for asthma exacerbations...
February 27, 2018: BMC Medical Genomics
https://www.readbyqxmd.com/read/29477568/asthma-phenotypes-defined-from-parameters-obtained-during-recovery-from-a-hospital-treated-exacerbation
#7
Rihuang Qiu, Jiaxing Xie, Kian Fan Chung, Naijian Li, Zhaowei Yang, Mengzhang He, Jing Li, Rongchang Chen, Nanshan Zhong, Qingling Zhang
BACKGROUND: Asthma is a heterogeneous disease with diverse clinical manifestations and inflammatory pathologies that is punctuated by exacerbations. OBJECTIVES: To describe the clinical and inflammatory characteristics of asthma patients treated in hospital for an acute exacerbation. METHODS: Data from 320 adult patients receiving treatment for an acute exacerbation of asthma were obtained. In 218 with complete data , we used Ward's hierarchical clustering to obtain clusters...
February 22, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29469993/asthma-among-adult-patients-presenting-with-dyspnea-to-the-emergency-department-an-observational-study
#8
Win Sen Kuan, Simon Craig, Anne-Maree Kelly, Gerben Keijzers, Sharon Klim, Colin A Graham, Peter Jones, Anna Holdgate, Charles Lawoko, Said Laribi
INTRODUCTION: Shortness of breath is a common presenting symptom to the emergency department (ED) that can arise from a myriad of possible diagnoses. Asthma is one of the major causes. OBJECTIVE: To describe the demographic features, clinical characteristics, management and outcomes of adults with an emergency department (ED) diagnosis of asthma who presented to an ED in the Asia Pacific region with a principal symptom of dyspnea. METHODS: Planned sub-study of patients with an ED diagnosis of asthma identified in the Asia, Australia and New Zealand Dyspnoea in Emergency Departments (AANZDEM) study...
February 22, 2018: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29460272/hyperglycemia-in-children-hospitalized-with-acute-asthma
#9
Khalid F Mobaireek, Abdulrahman Alshehri, Abdulaziz Alsadoun, Abdullah Alasmari, Abdullah Alashhab, Meshal Alrumaih, Mohammad Alothman, Abdullah A Alangari
Hyperglycemia is frequently observed in adults with acute asthma. We aimed to assess the frequency of hyperglycemia and its relation to outcomes in children admitted with acute asthma. In this retrospective study, we reviewed medical records of non-diabetic 166 children (66 girls) with the mean age of 5.4 ± 2.6 years (range of 2-12 years), who were hospitalized with acute asthma between January 2012 through December 2014. Data pertaining to demographics, vital signs, oxygen saturation, serum blood glucose level, electrolytes, blood gases, and admission were collected...
February 20, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29452277/association-between-obesity-and-acute-severity-among-patients-hospitalized-for-asthma-exacerbation
#10
Sarah Kyuragi Luthe, Atsushi Hirayama, Tadahiro Goto, Mohammad Kamal Faridi, Carlos A Camargo, Kohei Hasegawa
BACKGROUND: Although studies have demonstrated relations between obesity and incident asthma, little is known about the association of obesity with acute severity in adults hospitalized for asthma exacerbation. OBJECTIVES: To investigate the association of obesity with acute severity of asthma exacerbation. METHODS: This is a retrospective cohort study using population-based data of 8 geographically diverse US states from 2010 through 2013...
February 13, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29420096/gamma-globulin-replacement-therapy-in-uncontrolled-severe-asthma-associated-with-humoral-immunodeficiency-a-series-of-five-case-reports
#11
Angelica Tiotiu, Yves Martinet, Roger Jankowski, Philippe Devillier
We report on five adult cases of the rare association of asthma with humoral immunodeficiency (huID). All patients had uncontrolled asthma related to recurrent respiratory infections. Asthma was diagnosed according to the Global Initiative for Asthma (GINA) guidelines, and bronchiectasis was ruled out by a CT chest scan. Two men (aged 28 and 60) presented with pollen allergies, chronic rhinosinusitis, and IgG deficiency (7.8 and 7.6 g/L, respectively). Both patients underwent surgery for nasal polyposis but relapsed with acute sinusitis and severe asthma exacerbations requiring treatment with oral corticosteroids and antibiotics...
February 8, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29411238/hospital-level-care-at-home-for-acutely-ill-adults-a-pilot-randomized-controlled-trial
#12
David M Levine, Kei Ouchi, Bonnie Blanchfield, Keren Diamond, Adam Licurse, Charles T Pu, Jeffrey L Schnipper
BACKGROUND: Hospitals are standard of care for acute illness, but hospitals can be unsafe, uncomfortable, and expensive. Providing substitutive hospital-level care in a patient's home potentially reduces cost while maintaining or improving quality, safety, and patient experience, although evidence from randomized controlled trials in the US is lacking. OBJECTIVE: Determine if home hospital care reduces cost while maintaining quality, safety, and patient experience...
February 6, 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29391776/efficacy-and-side-effects-of-intravenous-theophylline-in-acute-asthma-a-systematic-review-and-meta-analysis
#13
Gulixian Mahemuti, Hui Zhang, Jing Li, Nueramina Tieliwaerdi, Lili Ren
Background and objective: Theophylline has been used for decades to treat both acute and chronic asthma. Despite its longevity in the practitioner's formulary, no detailed meta-analysis has been performed to determine the conditions, including concomitant medications, under which theophylline should be used for acute exacerbations of asthma. We aimed to quantify the usefulness and side effects of theophylline with or without ethylene diamine (aminophylline) in acute asthma, with particular emphasis on patient subgroups, such as children, adults, and concomitant medications...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29384116/anaphylaxis-in-a-food-allergy-outpatient-department-one-year-review
#14
R A Fernandes, F Regateiro, C Pereira, E Faria, J Pita, A Todo-Bom, I Carrapatoso
Background. Anaphylaxis is an acute, potentially fatal, multi-organ allergic reac-tion. Our aim was to characterize the population with food induced anaphylaxis followed over a one-year period. Methods. Retrospective analysis of clinical files of patients with food anaphylaxis observed in our food allergy consultation during 2016. Results. Sixty-two patients were included. In the pediatric group, the implicated allergens were cow's milk, egg and fish and in the adults' group, the commonest allergens were nuts and wheat...
March 2018: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29379280/airway-reactivity-to-mannitol-is-similarly-increased-in-chronic-cigarette-and-water-pipe-smokers
#15
Andreas Scherr, Jerome Schmidlin, Silvio Albisser, Michael Tamm, Daiana Stolz
Background: In contrast to cigarette smoking, the association between water pipe smoking and airway hyperresponsiveness remains widely unexplored. Methods: A bronchoprovocation challenge with mannitol was performed in young adults recruited at the University of Basel, Switzerland. Subjects were categorized as acute water pipe smokers (single episode of water pipe smoking, no or <0.5 pack-years cigarette smoking); chronic water pipe smokers (weekly for ≥4 weeks, no or <0...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29318574/prophylactic-benefits-of-systemically-delivered-simvastatin-treatment-in-a-house-dust-mite-challenged-murine-model-of-allergic-asthma
#16
Aruni Jha, Min H Ryu, Ojo Oo, Hilary J Bews, Jules C Carlson, Jacquie Schwartz, Sujata Basu, Charles S Wong, Andrew J Halayko
BACKGROUND AND PURPOSE: Systemically delivered statins can blunt airway inflammation in ovalbumin-challenged mice. However, in asthma clinical trials the beneficial effects of introducing oral statins are not compelling. We have invetigated this discrepancy using a clinically relevant murine model of allergic asthma, and by including a prophylactic study arm. EXPERIMENTAL APPROACH: Adult mice were: 1) challenged with house dust mite (HDM) alone or with subcutaneous (s...
April 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29279787/acute-chest-syndrome-in-children-with-sickle-cell-disease
#17
REVIEW
Shilpa Jain, Nitya Bakshi, Lakshmanan Krishnamurti
Acute chest syndrome (ACS) is a frequent cause of acute lung disease in children with sickle cell disease (SCD). Patients may present with ACS or may develop this complication during the course of a hospitalization for acute vaso-occlusive crises (VOC). ACS is associated with prolonged hospitalization, increased risk of respiratory failure, and the potential for developing chronic lung disease. ACS in SCD is defined as the presence of fever and/or new respiratory symptoms accompanied by the presence of a new pulmonary infiltrate on chest X-ray...
December 1, 2017: Pediatric Allergy, Immunology, and Pulmonology
https://www.readbyqxmd.com/read/29273246/asthma
#18
REVIEW
Alberto Papi, Christopher Brightling, Søren E Pedersen, Helen K Reddel
Asthma-one of the most common chronic, non-communicable diseases in children and adults-is characterised by variable respiratory symptoms and variable airflow limitation. Asthma is a consequence of complex gene-environment interactions, with heterogeneity in clinical presentation and the type and intensity of airway inflammation and remodelling. The goal of asthma treatment is to achieve good asthma control-ie, to minimise symptom burden and risk of exacerbations. Anti-inflammatory and bronchodilator treatments are the mainstay of asthma therapy and are used in a stepwise approach...
February 24, 2018: Lancet
https://www.readbyqxmd.com/read/29238240/the-effect-of-dpp-4-inhibitors-on-asthma-control-an-administrative-database-study-to-evaluate-a-potential-pathophysiological-relationship
#19
Gene Colice, David Price, Maria Gerhardsson de Verdier, Karma Rabon-Stith, Christopher Ambrose, Katherine Cappell, Debra E Irwin, Paul Juneau, Anna Vlahiotis
Rationale: DPP-4 may regulate immunological pathways implicated in asthma. Assessing whether DPP-4 inhibitor (DPP-4i) use might affect asthma control is clinically important because DPP-4i use in type 2 diabetes mellitus management (T2DM) is increasing. This study evaluated associations between DPP-4i use and asthma control. Methods: This was a retrospective, observational, matched cohort study using administrative claims in the MarketScan® Commercial Claims and Encounters (Commercial) and Medicare Supplemental and Coordination of Benefits (Medicare Supplemental) databases...
2017: Pragmatic and Observational Research
https://www.readbyqxmd.com/read/29232988/does-antibiotic-treatment-duration-affect-the-outcomes-of-exacerbations-of-asthma-and-copd-a-systematic-review
#20
Marie Stolbrink, Jack Amiry, John D Blakey
Asthma and chronic obstructive pulmonary disease (COPD) cause significant morbidity and mortality worldwide, primarily through exacerbations. Exacerbations are often treated with antibiotics but their optimal course duration is uncertain. Reducing antibiotic duration may influence antimicrobial resistance but risks treatment failure. The objective of this article is to review published literature to investigate whether shorter antibiotic therapy duration affects clinical outcomes in the treatment of asthma and COPD exacerbations...
January 1, 2017: Chronic Respiratory Disease
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