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Pulmonary function testing

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https://www.readbyqxmd.com/read/29049742/preoperative-six-minute-walk-distance-is-associated-with-pneumonia-after-lung-resection
#1
Keiko Hattori, Toshiaki Matsuda, Yui Takagi, Motoki Nagaya, Takayuki Inoue, Yoshihiro Nishida, Yoshinori Hasegawa, Koji Kawaguchi, Takayuki Fukui, Naoki Ozeki, Kohei Yokoi, Satoru Ito
OBJECTIVES: Little is known about the relationship between preoperative physical fitness and postoperative pneumonia after lung resection. We examined the association between preoperative 6-min walk distance (6MWD) and postoperative pneumonia. METHODS: A retrospective study was conducted on patients with malignant lung tumours who were scheduled to undergo lung resection at Nagoya University Hospital from January 2014 to December 2015. Preoperative pulmonary function tests and the 6-min walk test were assessed...
September 26, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29049191/significance-of-monitoring-plasma-concentration-of-voriconazole-in-a-patient-with-liver-failure-a-case-report
#2
Xiaoyan Liu, Haibin Su, Jingjing Tong, Jing Chen, Haozhen Yang, Long Xiao, Jinhua Hu, Lina Zhang
RATIONALE: Invasive pulmonary aspergillosis is associated with significant morbidity and mortality in patients with liver failure. Voriconazole (VRCZ) is recommended as a primary therapeutic agent for the treatment of invasive aspergillosis and metabolized in the liver. Now, data are still lacking on the safety and appropriate dosage of VRCZ in patients with liver failure. Here, we report a representative case of invasive pulmonary fungal infection in a patient with liver failure who was treated with low-dose VRCZ...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29048464/differences-in-postoperative-changes-in-pulmonary-functions-following-segmentectomy-compared-with-lobectomy
#3
Hiroaki Nomori, Atsushi Shiraishi, Yue Cong, Hiroshi Sugimura, Shuji Mishima
OBJECTIVES: To clarify differences in postoperative changes in systemic and regional pulmonary functions between segmentectomy and lobectomy in patients with lung cancer, we compared the 2 procedures using lung perfusion scintigraphy with a fusion image of single-photon emission computed tomography and computed tomography. METHODS: This study is a retrospective matched cohort study of consecutively acquired data. Pulmonary function tests and perfusion single-photon emission computed tomography/computed tomography were conducted before surgery and 6 months after surgery to measure changes in forced expiratory volume in 1 s of a whole lung, contralateral lung and a lobe...
October 18, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29045979/-changes-of-serum-krebs-von-den-lungen-6-levels-in-interstitial-lung-disease-associated-with-dermatomyositis-and-secondary-sj%C3%A3-gren-s-syndrome-a-case-report
#4
J F Yu, Y B Jin, J He, Y An, Z G Li
Interstitial lung diseases (ILDs) are a diverse group of pulmonary disorders characterized by various patterns of inflammation and fibrosis in the interstitium of the lung. The underlying pathogenesis of ILDs is complex and associated with multiple rheumatologic conditions, such as systemic sclerosis, rheumatoid arthritis, pollymyositis and dermatomyositis, Sjögren's syndrome, and systemic lupus erythematosus. As the disease progresses, excessive pulmonary fibrosis impairs alveolar gas exchange and damages pulmonary function...
October 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29045954/-pulmonary-arterial-hypertension-as-leading-manifestation-of-methylmalonic-aciduria-clinical-characteristics-and-gene-testing-in-15-cases
#5
X Q Liu, H Yan, J X Qiu, C Y Zhang, J G Qi, X Zhang, H J Xiao, Y L Yang, Y H Chen, J B DU
OBJECTIVE: To deepen our understanding of Methylmalonic aciduria (MMA) associated pulmonary hypertension (PH) by analyzing the characteristics of clinical presentation, pulmonary high resolusion CT(HRCT), treatment response and gene mutation. METHODS: This study includes 15 cases of pediatric patients with MMA associated PH diagnosed and treated in Peking University First Hospital pediatric department between May 2012 and May 2016 with symptoms of PH as their leading presentation...
October 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29045477/tubastatin-ameliorates-pulmonary-fibrosis-by-targeting-the-tgf%C3%AE-pi3k-akt-pathway
#6
Shigeki Saito, Yan Zhuang, Bin Shan, Svitlana Danchuk, Fayong Luo, Martina Korfei, Andreas Guenther, Joseph A Lasky
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and fatal disease. Histone deacetylase 6 (HDAC6) alters function and fate of various proteins via deacetylation of lysine residues, and is implicated in TGF-β1-induced EMT (epithelial-mesenchymal transition). However, the role of HDAC6 in pulmonary fibrosis is unknown. METHODS: HDAC6 expression in IPF and control lungs was assessed by quantitative real-time PCR (qRT-PCR) and immunoblots. Lung fibroblasts were treated with TGF-β1 ± HDAC6 inhibitors (Tubacin, Tubastatin, ACY1215, or MC1568), and fibrotic markers such as type I collagen were assessed using qRT-PCR and immunoblots...
2017: PloS One
https://www.readbyqxmd.com/read/29044345/first-report-of-granulicatella-sp-endocarditis-in-a-kidney-transplant-patient
#7
Flávio Jota de Paula, Precil Diego Miranda de Menezes Neves, Ramaiane Aparecida Bridi, Alice Tung Wan Song, Elias David-Neto
Granulicatella and Abiotrophia are genera of fastidious Gram-positive cocci commensal of the oral, genitourinary, and intestinal flora. We report the first case of infective endocarditis caused by Granulicatella sp. in a kidney transplant recipient. A 67-year-old male kidney transplant recipient was admitted to the hospital for investigation of fever, abdominal pain, and diarrhea. On physical examination, he was dehydrated. Laboratory tests identified impaired renal function (creatinine level of 15.5 mg/dl; reference, 3...
July 2017: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/29044160/eosinophilia-and-clinical-outcome-of-chronic-obstructive-pulmonary-disease-a-meta-analysis
#8
Jeffery Ho, Wajia He, Matthew T V Chan, Gary Tse, Tong Liu, Sunny H Wong, Czarina C H Leung, Wai T Wong, Sharon Tsang, Lin Zhang, Rose Y P Chan, Tony Gin, Joseph Leung, Benson W M Lau, William K K Wu, Shirley P C Ngai
Numerous studies have investigated the association between eosinophilia and clinical outcome of patients with chronic obstructive pulmonary disease (COPD) but the evidence is conflicting. We conducted a pooled analysis of outcome measures comparing eosinophilic and non-eosinophilic COPD patients. We searched articles indexed in four databases using Medical Subject Heading or Title and Abstract words including COAD, COPD, eosinophil, eosinophilia, eosinopenia from inception to December 2016. Observational studies and randomized controlled trials with parallel groups comparing COPD patients with and without eosinophilia were included...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29042461/how-do-we-improve-training-in-pulmonary-physiology-and-the-interpretation-of-lung-function-tests
#9
EDITORIAL
Gerrard Phillips
No abstract text is available yet for this article.
October 17, 2017: Thorax
https://www.readbyqxmd.com/read/29042177/antibiotic-exposure-and-interpersonal-variance-mask-the-effect-of-ivacaftor-on-respiratory-microbiota-composition
#10
Anton Y Peleg, Jocelyn Choo, Katherine Langan, Deirdre Edgeworth, Dominic Keating, John Wilson, Geraint B Rogers, Tom Kotsimbos
BACKGROUND: G551D is a class III mutation of the cystic fibrosis transmembrane regulator (CFTR) that results in impaired chloride channel function in cystic fibrosis (CF). Ivacaftor, a CFTR-potentiating agent improves sweat chloride, weight, lung function, and pulmonary exacerbation rate in CF patients with G551D mutations, but its effect on the airway microbiome remains poorly characterised. METHODS: Twenty CF patients with at least one G551D mutation from a single centre were recruited to a 4month double-blind, placebo-controlled, crossover study of ivacaftor with 28days of active treatment...
October 14, 2017: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/29041938/development-of-breath-test-for-pneumoconiosis-a-case-control-study
#11
Hsiao-Yu Yang, Ruei-Hao Shie, Che-Jui Chang, Pau-Chung Chen
BACKGROUND: Lipid peroxidation plays an important role in the pathogenesis of pneumoconiosis. Volatile organic compounds (VOCs) generated from lipid peroxidation might be used to detect pneumoconiosis. The objective of this study was to develop a breath test for pneumoconiosis. METHODS: A case-control study was designed. Breath and ambient air were analysed by gas chromatography/mass spectrometry. After blank correction to prevent contamination from ambient air, we used canonical discriminant analysis (CDA) to assess the discrimination accuracy and principal component analysis (PCA) to generate a prediction score...
October 17, 2017: Respiratory Research
https://www.readbyqxmd.com/read/29039839/-the-role-of-integrated-assessment-of-the-indicators-of-external-respiration-function-in-cardiac-surgical-patients
#12
O V Kamenskaja, A S Klinkova, I Ju Loginova, V V Lomivorotov, D N Ponomarev, D V Habarov, V N Lomivorotov
This literature review dedicated to the importance of an integrated assessment of external respiratory function in cardiovascular diseases (CVDs), including an analysis of up-to-date techniques, such as spirometry, body plethysmography, examination of the diffusing capacity of the lung, determination of O2 consumption with evaluation of the effectiveness of pulmonary ventilation. It considers the pathogenetic components of impairments in pulmonary ventilation and gas exchange, which develop in different CVDs, as well as during and after cardiac surgery...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/29039137/three-dimensional-image-in-lung-transplantation
#13
Toyofumi F Chen-Yoshikawa, Hiroshi Date
Three-dimensional computed tomography (3D-CT) technologies have been developed and, recently, high-speed and high-quality 3D-CT technologies have been introduced to the field of thoracic surgery. The purpose of this manuscript is to demonstrate the clinical application of 3D-CT technologies in lung transplantation. In Japan, because of the severe donor shortage, living-donor lobar lung transplantation (LDLLT) is essential, in addition to cadaveric lung transplantation. In LDLLT, size matching is a grave issue, since ideal size matching between donor and recipient is usually difficult because of the limited population of potential donor...
October 16, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29037654/systemic-sclerosis-association-between-physical-function-handgrip-strength-and-pulmonary-function
#14
Agnaldo José Lopes, Amanda Cristina Justo, Arthur Sá Ferreira, Fernando Silva Guimaraes
BACKGROUND: Systemic sclerosis (SSc) is a multisystem disease affecting the skin, respiratory system and skeletal muscles. In SSc patients, hand function disability is the major factor limiting daily activities. AIM: To evaluate the association of physical function with handgrip strength and pulmonary function in SSc patients. A further aim was to assess the relationship between handgrip strength and pulmonary function in patients with SSc. METHOD: A cross-sectional study in which 28 patients with SSc underwent isometric handgrip strength (IHGS) measurement and pulmonary function tests and completed the Health Assessment Questionnaire Disability Index (HAQ-DI) to measure physical function...
October 2017: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/29037603/mri-and-ct-lung-biomarkers-towards-an-in-vivo-understanding-of-lung-biomechanics
#15
REVIEW
Heather M Young, Rachel L Eddy, Grace Parraga
BACKGROUND: The biomechanical properties of the lung are necessarily dependent on its structure and function, both of which are complex and change over time and space. This makes in vivo evaluation of lung biomechanics and a deep understanding of lung biomarkers, very challenging. In patients and animal models of lung disease, in vivo evaluations of lung structure and function are typically made at the mouth and include spirometry, multiple-breath gas washout tests and the forced oscillation technique...
September 29, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/29037538/glucose-trajectories-in-cystic-fibrosis-and-their-association-with-pulmonary-function
#16
Quitterie Reynaud, Muriel Rabilloud, Sylvain Roche, Stéphanie Poupon-Bourdy, Jean Iwaz, Raphaële Nove-Josserand, Emilie Blond, Martine Laville, Cathy Llerena, Sébastien Quetant, Philippe Reix, Sandrine Touzet, Isabelle Durieu
BACKGROUND: The prevalence of cystic fibrosis-related diabetes is increasing. This condition is potentially responsible for respiratory decline. METHODS: At inclusion, then yearly (over three years), 111 children and 117 adults with cystic fibrosis had oral glucose tolerance and insulin tests at one (G1) and 2h (G2). KmL analysis identified homogeneous G1 and G2 glucose trajectories. A linear mixed model quantified the relationships between trajectories and FEV1 changes...
October 13, 2017: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/29035287/cardio-pulmonary-involvement-in-systemic-sclerosis-a-study-at-a-tertiary-care-center
#17
Geetakiran Arakkal, Sudha Rani Chintagunta, Vasavilatha Chandika, Sudha Vani Damarla, Srinivas Manchala, B Udaya Kumar
BACKGROUND: Systemic sclerosis is a multisystem disorder characterized by microangiopathy, dysregulation of the immune system and massive deposition of collagen in the connective tissue of the skin, blood vessels and various internal organs. Although the mortality from renal crises has dropped significantly due to the use of angiotensin-converting enzyme inhibitors, cardiac and pulmonary involvement accounts for significant morbidity and mortality. We studied 28 patients with systemic sclerosis at Gandhi Medical College and Hospital, Hyderabad, over a period of two years for cardiopulmonary involvement...
November 2017: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/29033563/role-of-inspiratory-capacity-on-dyspnea-evaluation-in-copd-with-or-without-emphysematous-lesions-a-pilot-study
#18
Liwei Cui, Xiuli Ji, Mengshuang Xie, Shuang Dou, Wei Wang, Wei Xiao
BACKGROUND: Since forced expiratory volume in 1 second (FEV1) shows a weak correlation with patients' symptoms in COPD, some volume parameters may better reflect the change in dyspnea symptoms after treatment. In this article, we investigated the role of inspiratory capacity (IC) on dyspnea evaluation among COPD patients with or without emphysematous lesions. METHODS: In this prospective study, 124 patients with stable COPD were recruited. During the baseline visit, patients performed pulmonary function tests and dyspnea evaluation using the modified Medical Research Council (mMRC) scale...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29033550/coach-to-cope-feasibility-of-a-life-coaching-program-for-young-adults-with-cystic-fibrosis
#19
Karin Bæk Knudsen, Tacjana Pressler, Laust Hvas Mortensen, Mary Jarden, Kirsten Arntz Boisen, Marianne Skov, Alexandra L Quittner, Terese Lea Katzenstein
BACKGROUND: Over the last two decades, lifespan has increased significantly for people living with cystic fibrosis (CF). However, several studies have demonstrated that many young adults with CF report mental health problems and poor adherence to their prescribed treatments, challenging their long-term physical health. Treatment guidelines recommend interventions to improve adherence and self-management. The aim of this study was to test the feasibility of a life coaching intervention for young adults with CF...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29032138/wedge-pressure-rather-than-left%C3%A2-ventricular-end-diastolic-pressure-predicts-outcome-in-heart-failure-with-preserved-ejection-fraction
#20
Julia Mascherbauer, Caroline Zotter-Tufaro, Franz Duca, Christina Binder, Matthias Koschutnik, Andreas A Kammerlander, Stefan Aschauer, Diana Bonderman
OBJECTIVES: This study sought to compare the prognostic power of left ventricular end-diastolic pressure (LVEDP) and pulmonary arterial wedge pressure (PAWP) in heart failure with preserved ejection fraction (HFpEF). BACKGROUND: It is broadly accepted that direct measurement of LVEDP in HFpEF more robustly reflects left ventricular hemodynamics than PAWP. METHODS: A total of 173 consecutive HFpEF patients were prospectively enrolled. Of these, 152 patients fulfilled registry inclusion criteria...
October 4, 2017: JACC. Heart Failure
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