keyword
MENU ▼
Read by QxMD icon Read
search

Pulmonary function testing

keyword
https://www.readbyqxmd.com/read/29690880/abnormal-pulmonary-function-tests-predict-the-development-of-radiation-induced-pneumonitis-in-advanced-non-small-cell-lung-cancer
#1
L Torre-Bouscoulet, W R Muñoz-Montaño, D Martínez-Briseño, F J Lozano-Ruiz, R Fernández-Plata, J A Beck-Magaña, C García-Sancho, A Guzmán-Barragán, E Vergara, M Blake-Cerda, L Gochicoa-Rangel, F Maldonado, M Arroyo-Hernández, O Arrieta
BACKGROUND: Radiation pneumonitis (RP) is a frequent complication of concurrent chemoradiotherapy (CCRT) and is associated with severe symptoms that decrease quality of life and might result in pulmonary fibrosis or death. The aim of this study is to identify whether pulmonary function test (PFT) abnormalities may predict RP in non-small cell lung cancer (NSCLC) patients. METHODS: A prospective multi-institutional study was conducted with locally advanced and oligometastatic NSCLC patients...
April 24, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29688528/smoking-systemic-inflammation-and-airflow-limitation-a-mendelian-randomization-analysis-of-98-085-individuals-from-the-general-population
#2
Yunus Çolak, Shoaib Afzal, Peter Lange, Børge G Nordestgaard
Introduction: Smoking is associated with systemic and local inflammation in the lungs. Furthermore, in chronic obstructive pulmonary disease (COPD), which is often caused by smoking, there is often systemic inflammation that is linked to lung function impairment. However, the causal pathways linking smoking, systemic inflammation, and airflow limitation are still unknown. We tested whether higher tobacco consumption is associated with higher systemic inflammation, observationally and genetically and whether genetically higher systemic inflammation is associated with airflow limitation...
April 24, 2018: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29687968/spinal-bracing-and-lung-function-in-type-2-spinal-muscular-atrophy
#3
Chiara Di Pede, Eleonora Salamon, Matteo Motta, Caterina Agosto, Franca Benini, Adriano Ferrari
BACKGROUND: Respiratory muscle weakness associated with scoliosis in type-2 spinal muscular atrophy (SMA) leads to respiratory impairment. Spinal brace, generally utilized to slow scoliosis progression and support sitting, could worsen lung function and hamper cough maneuvers. CASE SERIES: Six home-treated type-2 SMA children (aged 6 -15 years, subtype 2.1-2.5) were assessed to evaluate time-dependent influence of "static-balanced brace" on pulmonary function...
April 24, 2018: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29687210/relationship-between-interstitial-lung-disease-and-oesophageal-dilatation-on-chest-high-resolution-computed-tomography-in-patients-with-systemic-sclerosis-a-cross-sectional-study
#4
Fausto Salaffi, Marco Di Carlo, Marina Carotti, Paolo Fraticelli, Armando Gabrielli, Andrea Giovagnoni
OBJECTIVES: Oesophageal dilatation (OD) has been implicated in the pathogenesis of interstitial lung disease (ILD) in systemic sclerosis (SSc). The aims of this study were to explore the association of the OD and SSc-ILD on chest high-resolution computed tomography (HRCT), and to establish a cutoff point for the OD suggestive for the presence of a significant lung involvement. METHODS: The widest oesophageal diameter (WOD) was obtained on axial HRCT images. The parenchymal abnormalities on HRCT were coded and scored according to Warrick method...
April 23, 2018: La Radiologia Medica
https://www.readbyqxmd.com/read/29686742/time-to-exhale-additional-value-of-expiratory-chest-ct-in-chronic-obstructive-pulmonary-disease
#5
Joshua Gawlitza, Frederik Trinkmann, Hans Scheffel, Andreas Fischer, John W Nance, Claudia Henzler, Nils Vogler, Joachim Saur, Ibrahim Akin, Martin Borggrefe, Stefan O Schoenberg, Thomas Henzler
Objectives: Diagnostic guidelines for chronic obstructive pulmonary disease (COPD) are based on spirometry and clinical criteria. However, this does not address the pathophysiological complexity of the disease sufficiently. Until now, inspiratory chest computed tomography (CT) has been considered as the preferred imaging method in these patients. We hypothesized that expiratory CT may be superior to demonstrate pathophysiological changes. The aim of this prospective study was to systematically compare lung function tests with quantified CT parameters in inspiration and expiration...
2018: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/29685414/a-novel-capn3-mutation-in-late-onset-limb-girdle-muscular-dystrophy-with-early-respiratory-insufficiency
#6
Jennifer M Martinez-Thompson, Steven A Moore, Teerin Liewluck
We describe a 70 year-old independently ambulatory man with a 10-year history of progressive axial and limb-girdle weakness, hyperCKemia, and a 5-year history of dyspnea requiring nocturnal ventilatory support due to a known c.1309C>T (p.Arg437Cys) variant and a novel in-frame deletion of exons 17-19 in the calpain-3 encoding gene (CAPN3). Pulmonary function tests revealed neuromuscular respiratory weakness. Biceps femoris biopsy showed chronic myopathic changes, numerous lobulated fibers, and reduced calpain-3 immunoreactivity...
April 20, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29684318/does-size-matter-when-calculating-the-correct-tidal-volume-for-pediatric-mechanical-ventilation-a-hypothesis-based-on-forced-vital-capacity
#7
Gina J Kim, Christopher J L Newth, Robinder G Khemani, Suzy L Wong, Allan L Coates, Patrick A Ross
BACKGROUND: Tidal volumes standardized to predicted body weight are recommended for adult mechanical ventilation, but children are frequently ventilated using measured body weight. Our goal is to examine the difference in forced vital capacity (FVC ml/kg) using measured compared to predicted body weight in children. METHODS: Retrospective analysis of outpatient pulmonary function tests (PFTs) from two datasets. Dataset one: 6 to 19 year old children undergoing PFTs from the nationally-representative Canadian Health Measures Survey...
April 20, 2018: Chest
https://www.readbyqxmd.com/read/29684249/standard-head-down-tilt-versus-modified-without-head-down-tilt-postural-drainage-in-infants-and-young-children-with-cystic-fibrosis
#8
REVIEW
Diana A Freitas, Gabriela Ss Chaves, Thayla A Santino, Cibele Td Ribeiro, Fernando Al Dias, Ricardo O Guerra, Karla Mpp Mendonça
BACKGROUND: Postural drainage is used primarily in infants with cystic fibrosis from diagnosis up to the moment when they are mature enough to actively participate in self-administered treatments. However, there is a risk of gastroesophageal reflux associated with this technique.This is an update of a review published in 2015. OBJECTIVES: To compare the effects of standard postural drainage (15º to 45º head-down tilt) with modified postural drainage (15º to 30º head-up tilt) with regard to gastroesophageal reflux in infants and young children up to six years old with cystic fibrosis in terms of safety and efficacy...
March 9, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29684090/predictors-of-poor-outcome-in-patients-with-pulmonary-arterial-hypertension-a-single-center-study
#9
Emilia Stepnowska, Ewa Lewicka, Alicja Dąbrowska-Kugacka, Ludmiła Daniłowicz-Szymanowicz, Paweł Zagożdżon, Rafał Kamiński, Zuzanna Lewicka-Potocka, Paweł Miękus, Dariusz Kozłowski, Wojciech Potocki, Grzegorz Raczak
OBJECTIVES: Pulmonary arterial hypertension (PAH) is a rare disorder with unfavorable prognosis despite implementation of specific PAH-oriented therapy. The aim of the study was to define predictors of poor prognosis in patients from one center treated according to the Polish National Health Fund program. PATIENTS AND METHODS: Forty-seven consecutive patients (30 women; aged 39±17 years) with PAH diagnosis were enrolled to the study. Clinical assessment, laboratory measurements, electrocardiogram, echocardiography, 6-minute walk test, 24-hour Holter monitoring, cardiopulmonary exercise test and microvolt T-wave alternans test were performed during routine visits...
2018: PloS One
https://www.readbyqxmd.com/read/29682532/effect-of-upright-and-slouched-sitting-postures-on-the-respiratory-muscle-strength-in-healthy-young-males
#10
Ali Albarrati, Hamayun Zafar, Ahmad H Alghadir, Shahnwaz Anwer
Objective: The present study compared the effects of upright and slouched sitting postures on the respiratory muscle strength in healthy young males. Methods: A total of 35 adult male subjects aged 18-35 years participated in this study. Respiratory muscle strength was determined by measurement of sniff nasal inspiratory pressure (SNIP) using a MicroRPM device in the upright and slouched sitting positions. The subjects were asked to perform the pulmonary function test including peak expiratory flow (PEF), forced expiratory volume in one second (FEV1 ), forced vital capacity (FVC), and FEV1 /FVC ratio at baseline...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29681957/mechanical-circulatory-support-is-effective-to-treat-pulmonary-hypertension-in-heart-transplant-candidates-disqualified-due-to-unacceptable-pulmonary-vascular-resistance
#11
Michał Zakliczyński, Jerzy Pacholewicz, Izabela Copik, Marcin Maruszewski, Tomasz Hrapkowicz, Roman Przybylski, Marian Zembala
Introduction: High pulmonary vascular resistance (PVR) in orthotopic heart transplantation (OHT) candidates is a risk factor of right ventricle failure after the procedure. However, the increase of PVR may be a consequence of the life-threatening deterioration of the left ventricle function. The use of mechanical circulatory support (MCS) seems to be the best solution, but it is reimbursed only in active OHT candidates. Aim: We performed a retrospective analysis of MCS effectiveness in maintaining PVR at values accepted for OHT...
March 2018: Kardiochirurgia i Torakochirurgia Polska, Polish Journal of Cardio-Thoracic Surgery
https://www.readbyqxmd.com/read/29681931/development-of-a-physiological-frailty-index-for-the-world-trade-center-general-responder-cohort
#12
Ghalib A Bello, Roberto G Lucchini, Susan L Teitelbaum, Moshe Shapiro, Michael A Crane, Andrew C Todd
Responders to the 9/11/2001 WTC attacks were exposed to multiple toxic pollutants. Since 2002, the health of the responder cohort has been continuously tracked by the WTC Health Monitoring Program. However, no assessments have been made of frailty, an important health metric given the current average age of the WTC responder cohort (55 years). In this study, we use laboratory test results and other physiological parameters to construct a physiological frailty index (FI-Lab) for this cohort. The study sample comprised responders aged 40 years or older who completed a health monitoring visit at Mount Sinai Center within the past 5 years...
2018: Current Gerontology and Geriatrics Research
https://www.readbyqxmd.com/read/29680371/the-immunomodulatory-role-of-zinc-in-asthmatic-patients
#13
Nesrine A Mohamed, Marwa Rushdy, Asmaa S M Abdel-Rehim
BACKGROUND: Zinc deficiency may play an important role in the development of atopic asthma. THE AIM OF THE WORK: To assess serum zinc levels in adult atopic, non-atopic asthmatic patients, and in healthy controls and to investigate its modulatory effect on production of interferon gamma (IFN-γ) and interleukin-10 (IL-10) by peripheral blood mononuclear cells (PBMCs) in vitro. METHODS: Sixty asthmatics and 30 apparently healthy volunteers were included in this study...
April 18, 2018: Cytokine
https://www.readbyqxmd.com/read/29679771/extracorporeal-photopheresis-improves-survival-in-hematopoietic-cell-transplant-patients-with-bronchiolitis-obliterans-syndrome-without-significantly-impacting-measured-pulmonary-functions
#14
Mehrdad Hefazi, Kimberly J Langer, Nandita Khera, Jill Adamski, Vivek Roy, Jeffrey L Winters, Dennis A Gastineau, Eapen K Jacob, Justin D Kreuter, Manish J Gandhi, William J Hogan, Mark R Litzow, Shahrukh K Hashmi, Hemang Yadav, Vivek N Iyer, J P Scott, Mark E Wylam, Rodrigo Cartin-Ceba, Mrinal M Patnaik
We carried out the first matched retrospective cohort study aimed at studying the safety and efficacy of extracorporeal photopheresis (ECP) for bronchiolitis obliterans syndrome (BOS) following allogeneic hematopoietic cell transplantation (HCT). Medical records of 1325 consecutive adult patients who underwent HCT between 2005 and 2015 were reviewed. Seventy-four patients (median age, 51 years) with a diagnosis of BOS were included in the study. After propensity-score matching for BOS severity, 26 patients who underwent ≥3 months of ECP were matched to 26 non-ECP-treated patients, who were assigned an index date corresponding to the ECP start date for their matched pairs...
April 18, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29678906/rnai-screening-identifies-a-mechanosensitive-rock-jak2-stat3-network-central-to-myofibroblast-activation
#15
Raymond S Oh, Andrew J Haak, Karry M J Smith, Giovanni Ligresti, Kyoung Moo Choi, Tiao Xie, Shaohua Wang, Paula R Walters, Michael A Thompson, Michelle R Freeman, Logan J Manlove, Vivian M Chu, Carol Feghali-Bostwick, Anja C Roden, Jürgen Schymeinsky, Christina M Pabelick, Y S Prakash, Robert Vassallo, Daniel J Tschumperlin
Myofibroblasts play key roles in wound healing and pathologic fibrosis. Here we undertook an RNAi screen to characterize myofibroblast regulatory genes, using a high-content imaging approach to quantify alpha-smooth muscle actin stress fibers in cultured human fibroblasts. Screen hits were validated on physiological compliance hydrogels, and selected hits tested in primary fibroblasts from patients with idiopathic pulmonary fibrosis. Our RNAi screen led to the identification of STAT3 as an essential mediator of myofibroblast activation and function...
April 20, 2018: Journal of Cell Science
https://www.readbyqxmd.com/read/29678450/effects-of-exercise-training-on-pulmonary-function-in-adults-with-chronic-lung-disease-a-meta-analysis-of-randomized-controlled-trials
#16
REVIEW
Pablo A Salcedo, Jacob B Lindheimer, Jacquelyn C Klein-Adams, Anays M Sotolongo, Michael J Falvo
OBJECTIVE: To quantify the effect of exercise training on indices of pulmonary function in adults with chronic lung disease using meta-analytic techniques. Whole body exercise training is well-known to confer favorable adaptations to multiple organ systems; however, exercise-induced adaptations to the respiratory system are assumed to be limited, if present at all, but have not been systematically reviewed. DATA SOURCES: Eligible trials were identified using a systematic search of Medline, Web of Science, Physiotherapy Evidence Database (PEDro) and GoogleScholar databases...
April 17, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29678139/pulmonary-hemosiderosis-in-children-with-down-syndrome-a-national-experience
#17
Aurelia Alimi, Jessica Taytard, Rola Abou Taam, Véronique Houdouin, Aude Forgeron, Marc Lubrano Lavadera, Pierrick Cros, Isabelle Gibertini, Jocelyne Derelle, Antoine Deschildre, Caroline Thumerelle, Ralph Epaud, Philippe Reix, Michael Fayon, Sylvie Roullaud, Françoise Troussier, Marie-Catherine Renoux, Jacques de Blic, Sophie Leyronnas, Guillaume Thouvenin, Caroline Perisson, Aimé Ravel, Annick Clement, Harriet Corvol, Nadia Nathan
BACKGROUND: Pulmonary hemosiderosis is a rare and complex disease in children. A previous study from the French RespiRare® network led to two important findings: 20% of the children presented with both pulmonary hemosiderosis and Down syndrome (DS), and at least one tested autoantibody was found positive in 50%. This study investigates the relationships between pulmonary hemosiderosis and DS. METHODS: Patients younger than 20 years old and followed for pulmonary hemosiderosis were retrieved from the RespiRare® database...
April 20, 2018: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/29676936/pediatric-metabolic-outcome-comparisons-based-on-a-spectrum-of-obesity-and-asthmatic-symptoms
#18
Ashley D Perdue, Lesley A Cottrell, Christa L Lilly, William A Gower, Brian A Ely, Brad Foringer, Melvin L Wright, William A Neal
RATIONALE: Asthma and obesity are two of the most prevalent public health issues for children in the U.S. Trajectories of both have roughly paralleled one another over the past several decades causing many to explore their connection to one another and to other associated health issues such as diabetes and dyslipidemia. Earlier models have commonly designated obesity as the central hub of these associations; however, more recent models have argued connections between pediatric asthma and other obesity-related metabolic conditions regardless of children's obesity risk...
April 20, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29676628/increasing-the-resolution-of-chronic-obstructive-pulmonary-disease-definition-lessons-from-a-cohort-with-remote-but-extensive-exposure-to-secondhand-tobacco-smoke
#19
Mehrdad Arjomandi, Siyang Zeng, Paul D Blanc, Warren M Gold
RATIONALE: The Global Initiative for Chronic Obstructive Lung Disease criteria require a ratio of forced expiratory volume in 1 second (FEV1 ) to forced vital capacity (FVC) (FEV1 /FVC) of less than 0.70 for the diagnosis of chronic obstructive pulmonary disease, whereas other criteria emphasize a lower limit of normal approach. However, the use of Global Initiative for Chronic Obstructive Lung Disease (or lower limit of normal) criteria may result in classification of many smokers with respiratory morbidities as not having chronic obstructive pulmonary disease...
April 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29676590/emphysema-management-from-investigational-endobronchial-coils-to-lung-transplantation
#20
Harpreet Singh Grewal, Atul C Mehta
This brief imaging case report highlights a successful bridge to lung transplantation after endobronchial coil assisted lung volume reduction procedure. Our patient was a 64-year-old male with severe emphysema (FEV1:19%, RV: 289%, TLC: 143%), on maximum medical regimen who was enrolled into the Lung Volume Reduction Coil Treatment (RENEW) Study. He underwent bilateral endobronchial coil placement in a two-step procedure, with an immediate improvement in symptoms and pulmonary function testing (FEV1:21%, RV: 254%, TLC: 138%)...
April 20, 2018: American Journal of Respiratory and Critical Care Medicine
keyword
keyword
116113
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"