keyword
https://read.qxmd.com/read/38281148/a-new-onset-drug-induced-diabetes-mellitus-presenting-with-diabetic-ketoacidosis-in-a-child-undergoing-treatment-for-b%C3%A2-cell-acute-lymphoblastic-leukemia-a-case-report-and-review-of-literature
#1
Preeti Sharma, Varuna Vyas, Siyaram Didel, Kuldeep Singh
OBJECTIVES: Hyperglycemia is a known side effect of anticancer chemotherapeutic drugs. This entity known as drug-induced diabetes mellitus usually does not present with the development of diabetic ketoacidosis (DKA). We hereby report a case of drug induced diabetes mellitus in a child with acute leukemia presenting with DKA. CASE PRESENTATION: We report a case of a teenage boy diagnosed with B cell acute lymphoblastic leukemia and was started on induction phase chemotherapy as per the Indian Collaborative Childhood Leukemia group (ICICLe) acute lymphoblastic leukemia-14 protocol...
January 29, 2024: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://read.qxmd.com/read/37634213/molecular-modeling-and-optimization-of-type-ii-e-coli-l-asparginase-activity-by-in-silico-design-and-in-vitro-site-directed-mutagenesis
#2
JOURNAL ARTICLE
Mahdieh Mahboobi, Ali-Hatef Salmanian, Hamid Sedighian, Bijan Bambai
INTRODUCTION: L-asparaginase (also known as L-ASNase) is a crucial therapeutic enzyme that is widely used in treatment of ALL (acute lymphoblastic leukemia) as a chemotherapeutic drug. Besides, this enzyme is used in the food industry as a food processing reagent to reduce the content of acrylamide in addition to the clinical industry. The improvement of activity and kinetic parameters of the L-ASNase enzyme may lead to higher efficiency resulting in practical achievement. In order to achieve this goal, we chosen glycine residue in position 88 as a potential mutation with advantageous outcomes...
August 27, 2023: Protein Journal
https://read.qxmd.com/read/35817486/grade-4-very-severe-hypertriglyceridaemia-at-diagnosis-in-a-child-with-acute-lymphoblastic-leukaemia
#3
JOURNAL ARTICLE
Sanjeev Khera, Ravi Kapoor, Shyam Sunder, Deepti Mahajan
Dyslipidaemia is seen in nearly all cases of acute lymphoblastic leukaemia (ALL) at diagnosis, with mild hypertriglyceridaemia (HTG) in 61% and reduced high-density lipoprotein in 98% cases. HTG irrespective of severity is due to metabolic derangements associated with tumour cells turnover in haematological malignancies and is generally self-limiting. Very severe HTG with overt lipaemic serum is extremely rare at presentation in ALL. HTG is complicated by thrombosis, osteonecrosis and pancreatitis during induction chemotherapy for ALL with steroids and L-asparginase...
July 11, 2022: BMJ Case Reports
https://read.qxmd.com/read/34117356/nk-t-cell-lymphomas
#4
REVIEW
Hua Wang, Bi-Bo Fu, Robert Peter Gale, Yang Liang
Natural killer/T-cell lymphoma (NKTL) is a sub-type of Epstein-Barr virus (EBV)-related non-Hodgkin lymphomas common in Asia and Latin America but rare elsewhere. Its pathogenesis is complex and incompletely understood. Lymphoma cells are transformed from NK- or T-cells, sometimes both. EBV-infection and subsequent genetic alterations in infected cells are central to NKTL development. Hemophagocytic syndrome is a common complication. Accurate staging is important to predict outcomes but there is controversy which system is best...
September 2021: Leukemia
https://read.qxmd.com/read/31613845/characterizing-iranian-pediatric-patients-with-relapsed-acute-lymphoblastic-leukemia-through-gene-expression-profiling-of-common-atp-binding-cassette-transporters-subfamily-c
#5
JOURNAL ARTICLE
Narjes Mehrvar, Hassan Abolghasemi, Mohammad R Rezvany, Mohammad E Akbari, Javad Saberynejad, Azim Mehrvar, Abolfazl Movafagh
BACKGROUND: The correlation between gene expression of ABCC transporters and recurrence as a treatment failure in pediatric patients with acute lymphoblastic leukemia (ALL) is an unsolved problem in scientific associations. The aim of this study was to evaluate the predictive value of ABCC1-6 gene expression pattern for estimating recurrence in Iranian pediatric patients with ALL. MATERIALS AND METHODS: Iranian pediatric patients with approved ALL enrolled in this study as 2 groups of case (relapsed ALL) and control (treated individuals who lasted for >3 years following their final treatment)...
January 2020: Journal of Pediatric Hematology/oncology
https://read.qxmd.com/read/29406239/coagulopathic-side-effect-of-l-asparaginase-on-fibrinogen-level-in-childhood-acute-lymphoblastic-leukemia-during-induction-phase
#6
JOURNAL ARTICLE
Alauldeen Mudhafar Zubair Alqasim, Raji Hussein Al-Hadithi, Aseel Nashaat Al-Khalidi
BACKGROUND: L-asparaginase is chemotherapeutic agent commonly used in treatment of Acute Lymphoblastic Leukemia. Thromboembolic and to a lesser extent bleeding events are serious complications associated with administration of this drug during the induction phase in ALL especially in children resulting from reduced synthesis of proteins such as Antithrombin & fibrinogen. OBJECTIVE: Evaluation of the coagulopathic side effect of L-asparaginase during the induction phase in treatment of ALL in children by measuring fibrinogen levels before & after administration of this drug...
March 2019: Hematology/oncology and Stem Cell Therapy
https://read.qxmd.com/read/28831914/enhancement-in-biological-activity-of-l-asparginase-by-its-conjugation-on-silica-nanoparticles
#7
JOURNAL ARTICLE
Dorsa Golestaneh, Jaleh Varshosaz
BACKGROUND: L-asparaginase is a drug of choice in the treatment of Hodgkin's lymphoma and acute lymphoblastic leukemia. Production of its bioconjugates can increase its half-life, stability and decrease its immunogenicity. OBJECTIVE: The aim of the present study was to immobilize this drug on silica nanoparticles by two different cross-linking agents. METHOD: The drug was conjugated to nanoparticles by two cross-linking agents; 1-ethyl-3-(3- dimethylaminopropyl) carboiimide HCl (EDC) or glutaraldehyde...
February 14, 2018: Recent Patents on Nanotechnology
https://read.qxmd.com/read/27972454/cost-minimization-analysis-of-peg-l-asparginase-versus-e-coli-l-asparaginase-in-pediatric-acute-lymphoblastic-leukemia-all-patients-a-jordanian-perspective
#8
JOURNAL ARTICLE
Al Rabayah, S Jaddouh, A Amireh
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://read.qxmd.com/read/27889709/role-of-mid-induction-peripheral-blood-minimal-residual-disease-detection-in-pediatric-b-lineage-acute-lymphoblastic-leukemia
#9
JOURNAL ARTICLE
Karthik Bommannan, Man Updesh Singh Sachdeva, Neelam Varma, Parveen Bose, Deepak Bansal
OBJECTIVE: To study the role of mid-induction (day 15) peripheral blood minimal residual disease (PB-MRD) detection in pediatric B- lineage acute lymphoblastic leukemia (B-ALL). DESIGN: Prospective. SETTING: Tertiary-care center. PATIENTS: 40 consecutively-diagnosed treatment-naive, pediatric B-ALL patients. INTERVENTION: National Cancer Institute (NCI) standard risk patients were given three drug induction regimen comprising vincristine, L-asparginase and prednisolone; NCI high-risk patients were supplemented with daunorubicin...
December 15, 2016: Indian Pediatrics
https://read.qxmd.com/read/24968963/l-asparginase-administration-reduces-white-blood-cell-count-and-prevents-tumor-lysis-syndrome-in-children-with-hyperleukocytic-acute-lymphoblastic-leukemia
#10
JOURNAL ARTICLE
Vishal Sondhi, Aditi Sharma, Manish Taneja, Brijesh Arora, Sripad D Banavali
BACKGROUND: The management of hyperleukocytosis currently involves intensive supportive care for preventing tumor lysis syndrome (TLS)-associated metabolic abnormalities as well as cytoreduction procedures to reduce the white blood cell (WBC) count. These procedures are often equipment-intensive and may not be practised in developing countries with limited resources. Hence, it is not clear what would be the most effective strategy to manage hyperleukocytosis and prevent TLS. PROCEDURE: All children ≤12 years, diagnosed with acute lymphoblastic leukemia (ALL) and hyperleukocytosis (WBC count >100 × 10(9)/l) were administered L-asparginase (L-asp, 6,000 U/m(2), i...
2015: Acta Haematologica
https://read.qxmd.com/read/24428625/asparaginase-associated-pancreatitis-in-children-with-acute-lymphoblastic-leukaemia-in-the-nopho-all2008-protocol
#11
JOURNAL ARTICLE
Raheel A Raja, Kjeld Schmiegelow, Birgitte K Albertsen, Kaie Prunsild, Bernward Zeller, Goda Vaitkeviciene, Jonas Abrahamsson, Mats Heyman, Mervi Taskinen, Arja Harila-Saari, Jukka Kanerva, Thomas L Frandsen
L-asparaginase is an important drug in the treatment of childhood acute lymphoblastic leukaemia (ALL). Treatment is associated with several toxicities, including acute pancreatitis. Clinical course, presentation, re-exposure to L-asparginase after pancreatitis and risk of recurrent pancreatitis within an asparaginase-intensive protocol has been poorly reported. Children (1-17 years) on the ongoing Nordic Society of Paediatric Haematology and Oncology (NOPHO) ALL2008 protocol with asparaginase-associated pancreatitis (AAP) diagnosed between 2008 and 2012 were identified through the online NOPHO ALL toxicity registry...
April 2014: British Journal of Haematology
https://read.qxmd.com/read/24426746/l-asparginase-induced-pseudopancreatic-cyst-a-rare-case-report
#12
S M Abhayakumar, Samit Purohit, B S Arunakumari, K C Lakshmaiah, L Appaji
L-Asparginase is a frequently used drug in hematological malignancies. Various side effects associated with its use include hypersensitivity, hyperglycemia, hypercoaguability and acute pancreatitis. We describe a rare complication of pancreatic pseudocyst in a 12 year old boy of Acute lymphoblastic leukemia (ALL) treated with MCP-841 protocol (during re-induction phase). Nearing the end of induction i.e. day 25, patient complained of a painful swelling in the epigastrium and left hypochondrium. Investigations revealed a pancreatic pseudocyst for which he underwent cystojejunostomy...
September 2013: Indian Journal of Surgical Oncology
https://read.qxmd.com/read/24396128/epidural-hematoma-in-a-patient-on-pegylated-l-asparginase-therapy
#13
JOURNAL ARTICLE
William F Qubty, Anna Mrelashvili, Marc C Patterson
No abstract text is available yet for this article.
April 2015: Journal of Child Neurology
https://read.qxmd.com/read/22629100/l-asparginase-induced-cortical-venous-thrombosis-in-a-patient-with-acute-leukemia
#14
Biswajit Dubashi, Ankit Jain
L-Asparginase is used for remission induction in acute lymphoblastic leukemia. We describe a case of 16-year-old boy who developed cortical venous thrombosis following the administration of L-Asparginase.
April 2012: Journal of Pharmacology & Pharmacotherapeutics
https://read.qxmd.com/read/12549621/intravascular-lymphoma-involving-the-central-and-peripheral-nervous-systems-in-a-dog
#15
JOURNAL ARTICLE
William W Bush, Juliene L Throop, Patricia M McManus, Amy S Kapatkin, Charles H Vite, Tom J Van Winkle
A 5-year-old, castrated male mixed-breed dog was presented for paraparesis, ataxia, hyperesthesia, and thrombocytopenia of 5 months' duration and recurrent seizures during the preceding 2 weeks. Multifocal neurological, ophthalmological, pulmonary, and cardiac diseases were identified. Magnetic resonance imaging and cerebrospinal fluid analysis supported a tentative diagnosis of neoplastic or inflammatory disease. A computed tomography-guided biopsy provided both cytopathological and histopathological evidence of intravascular lymphoma...
January 2003: Journal of the American Animal Hospital Association
https://read.qxmd.com/read/12161371/platelet-aggregation-is-stimulated-by-l-asparginase-in-children-with-acute-lymphoblastic-leukemia-and-normal-individuals
#16
JOURNAL ARTICLE
José Carlos Jaime-Perez, David Gomez-Almaguer
No abstract text is available yet for this article.
August 2002: Haematologica
https://read.qxmd.com/read/7564153/-long-term-infusion-of-l-asparaginase-an-alternative-to-intramuscular-injection
#17
COMPARATIVE STUDY
T Rodriguez, E Baumgarten, R Fengler, D Soumpasis, G Henze
Nine children of the ALL-REZ BFM 87 and 90 trial received L-Asparginase (L-ASP) as a continuous infusion for 48-72 hs (i.e. 25 therapy cycles). Seven patients had had an allergic reaction towards an i.m. application (i.m., 29 therapy cycles). Two further patients got L-ASP initially as continuous infusion. The i.m. applications were carried out 19 times with Erwinia and 10 times with E. coli-Asparaginase, the continuous infusions 15 times with Erwinia and 10 times with E. coli-Asparaginase. In case of four patients continuous infusions of the same L-ASP type (E...
July 1995: Klinische Pädiatrie
https://read.qxmd.com/read/5577383/-l-asparginase-in-childhood-leukemia
#18
JOURNAL ARTICLE
P J Moe
No abstract text is available yet for this article.
April 10, 1971: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
https://read.qxmd.com/read/4626307/toxicity-of-l-asparginase-in-children-with-advanced-leukemia
#19
JOURNAL ARTICLE
V J Land, W W Sutow, D J Fernbach, D M Lane, T E Williams
No abstract text is available yet for this article.
August 1972: Cancer
https://read.qxmd.com/read/1092544/immobilized-l-asparginase-embedded-in-fibrin-polymer
#20
JOURNAL ARTICLE
Y Inada, S Hirose, M Okada, H Mihama
Immobilized asparaginase was prepared by embedding asparaginase (which is effective for remission in children with leukemia) into fibrin polymer formed by fibrinogen-fibrin conversion in the presence of thrombin. The immobilized asparaginase film did not dissolve in 6 mol/1 urea, suggesting that blood coagulation factor XIII participates in the cross-linking between fibrins and between fibrin and asparaginase.
1975: Enzyme
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