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Transient diabetes mellitus

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https://www.readbyqxmd.com/read/29449530/the-type-2-diabetes-associated-hmg20a-gene-is-mandatory-for-islet-beta-cell-functional-maturity
#1
Jose M Mellado-Gil, Esther Fuente-Martín, Petra I Lorenzo, Nadia Cobo-Vuilleumier, Livia López-Noriega, Alejandro Martín-Montalvo, Irene de Gracia Herrera Gómez, Maria Ceballos-Chávez, Laura Gómez-Jaramillo, Antonio Campos-Caro, Silvana Y Romero-Zerbo, Júlia Rodríguez-Comas, Joan-Marc Servitja, Gemma Rojo-Martinez, Abdelkrim Hmadcha, Bernat Soria, Marco Bugliani, Piero Marchetti, Francisco J Bérmudez-Silva, Jose C Reyes, Manuel Aguilar-Diosdado, Benoit R Gauthier
HMG20A (also known as iBRAF) is a chromatin factor involved in neuronal differentiation and maturation. Recently small nucleotide polymorphisms (SNPs) in the HMG20A gene have been linked to type 2 diabetes mellitus (T2DM) yet neither expression nor function of this T2DM candidate gene in islets is known. Herein we demonstrate that HMG20A is expressed in both human and mouse islets and that levels are decreased in islets of T2DM donors as compared to islets from non-diabetic donors. In vitro studies in mouse and human islets demonstrated that glucose transiently increased HMG20A transcript levels, a result also observed in islets of gestating mice...
February 15, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29440471/clinical-and-demographic-characteristics-associated-with-suboptimal-primary-stroke-and-transient-ischemic-attack-prevention-retrospective-analysis
#2
Grace M Turner, Melanie Calvert, Max G Feltham, Ronan Ryan, Samuel Finnikin, Tom Marshall
BACKGROUND AND PURPOSE: Primary prevention of stroke and transient ischemic attack (TIA) is important to reduce the burden of these conditions; however, prescribing of prevention drugs is suboptimal. We aimed to identify individual clinical and demographic characteristics associated with potential missed opportunities for prevention therapy with lipid-lowering, anticoagulant, or antihypertensive drugs before stroke/TIA. METHODS: We analyzed anonymized electronic primary care records from a UK primary care database that covers 561 family practices...
February 13, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29433422/the-effect-of-noise-exposure-on-insulin-sensitivity-in-mice-may-be-mediated-by-the-jnk-irs1-pathway
#3
Lijie Liu, Cong Fang, Jing Yang, Hongyu Zhang, Yi Huang, Chuanying Xuan, Yongfang Wang, Shengwei Li, Jun Sha, Mingming Zha, Min Guo
BACKGROUND: Epidemiological studies have suggested that noise exposure may increase the risk of type 2 diabetes mellitus (T2DM), and experimental studies have demonstrated that noise exposure can induce insulin resistance in rodents. The aim of the present study was to explore noise-induced processes underlying impaired insulin sensitivity in mice. METHODS: Male ICR mice were randomly divided into four groups: a control group without noise exposure and three noise groups exposed to white noise at a 95-dB sound pressure level for 4 h/day for 1, 10, or 20 days (N1D, N10D, and N20D, respectively)...
February 12, 2018: Environmental Health and Preventive Medicine
https://www.readbyqxmd.com/read/29425312/risk-factors-for-early-intraocular-pressure-elevation-after-cataract-surgery-in-a-cohort-of-united-states-veterans
#4
Kaushik Annam, Allison J Chen, Irene M Lee, Alfred A Paul, Jorge J Rivera, Paul B Greenberg
Introduction: Cataract surgery is the most frequently performed surgery in the Veterans Health Administration (VHA). A well-known complication is a transient but potentially harmful elevation in intraocular pressure (IOP) within the 24-h postoperative period. The purpose of this study is to investigate the risk factors for IOP elevation 1 d after cataract surgery in a cohort of United States (US) veterans. Materials and Methods: The study included 784 patients who underwent cataract surgery between April 2013 and April 2016 at a single Veterans Affairs medical center in Providence, RI...
February 7, 2018: Military Medicine
https://www.readbyqxmd.com/read/29387335/contemporary-utilization-of-antithrombotic-therapy-for-stroke-prevention-in-patients-with-atrial-fibrillation-an-audit-in-an-australian-hospital-setting
#5
Ekta Yogeshkumar Pandya, Elizabeth Anderson, Clara Chow, Yishen Wang, Beata Bajorek
Background: To document antithrombotic utilization in patients with nonvalvular atrial fibrillation (NVAF), particularly, recently approved NOACs (nonvitamin K antagonist oral anticoagulants) and warfarin; and identify factors predicting the use of NOACs versus warfarin. Methods: A retrospective audit was conducted in an Australian hospital. Data pertaining to inpatients diagnosed with atrial fibrillation (AF) admitted between January and December 2014 were extracted...
February 2018: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/29386451/-recent-trends-of-trace-element-studies-in-clinical-medicine-in-japan
#6
Hiroko Kodama
The deficiency or excess intake of trace elements, including zinc, copper, selenium and iodine, has often been reported. Zinc deficiency is often observed in infants fed breast milk with low zinc concentration, individuals administered chelating medicines, athletes and patients with diabetes mellitus, hepatic cirrhosis or nephrosis syndrome. Menkes disease is associated with severe copper deficiency, and there is no effective treatment. Deficiencies of selenium and iodine are observed in patients who receive special formulas of milk and enteral formula with low selenium and iodine concentrations, respectively...
2018: Nihon Eiseigaku Zasshi. Japanese Journal of Hygiene
https://www.readbyqxmd.com/read/29381974/stroke-risks-and-patterns-of-warfarin-therapy-among-atrial-fibrillation-patients-post-radiofrequency-ablation-a-real-world-experience
#7
Juan Zhang, Xingpeng Liu, Xiaoqing Liu, Xiandong Yin, Yanjiang Wang, Xiaoying Lu, Xinchun Yang
We assessed the thromboembolic risks of atrial fibrillation (AF) patients who had undergone radiofrequency ablation (RFA) using the CHADS2-VASc risk scoring system and further investigated the patterns of warfarin use for thromboprophylaxis according to patient thromboembolic risk scores.In this study, we analyzed the stroke risks of patients who had undergone RFA for AF at our hospital between March 2014 and June 2016 using the CHADS2, CHADS2-VASc, and Hypertension, Abnormal renal/liver function, Stroke, Bleeding history or predisposition, Labile international normalized ratio, Elderly (> 65 years) (HAS-BLED) scoring systems...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29375830/neonatal-diabetes-mellitus-improved-screening-and-early-management-of-an-underestimated-disease
#8
Maëlle Wirth, Jean-Marc Jellimann, Stéphanie Jellimann, Jean-Michel Hascoët
Neonatal diabetes mellitus is underdiagnosed in the neonatal period because of the metabolic adaptation capacities of the newborns. However, it is associated with increased risk of short- and long-term morbidity; when transient it may recurs in adulthood. It is important to improve screening and early management with appropriate guidelines.
January 2018: Clinical Case Reports
https://www.readbyqxmd.com/read/29370349/left-atrial-appendage-resection-can-be-performed-minimally-invasively-with-good-clinical-and-echocardiographic-outcomes-without-any-severe-risk
#9
Takafumi Inoue, Yoshihiro Suematsu
OBJECTIVES: The adverse effects of left atrial appendage (LAA) closure have not yet been evaluated. This study aimed to prove the safety and low invasiveness of LAA resection through our thoracoscopic stand-alone left atrial appendectomy experience. METHODS: Eighty-seven patients [mean age 68 ± 9 years, 68 men (78%), mean congestive heart failure, hypertension, age ≥ 75 years, diabetes mellitus, prior stroke or transient ischaemic attack to thromboembolism, vascular disease, age 65-74 years and sex category (CHA2DS2-VASc) score 2...
January 22, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29367417/comparative-cardiovascular-risk-of-abatacept-and-tumor-necrosis-factor-inhibitors-in-patients-with-rheumatoid-arthritis-with-and-without-diabetes-mellitus-a-multidatabase-cohort-study
#10
Eun Ha Kang, Yinzhu Jin, Gregory Brill, Jennifer Lewey, Elisabetta Patorno, Rishi J Desai, Seoyoung C Kim
BACKGROUND: We examined the cardiovascular risk of abatacept compared with tumor necrosis factor (TNF) inhibitors in patients with rheumatoid arthritis with and without diabetes mellitus (DM). METHODS AND RESULTS: We conducted a cohort study of patients with rheumatoid arthritis who newly started abatacept or TNF inhibitors using claims data from Medicare and MarketScan. The primary outcome was a composite cardiovascular end point of myocardial infarction (MI), stroke/transient ischemic attack, and coronary revascularization...
January 24, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29366344/complications-after-multiple-site-peripheral-nerve-blocks-for-foot-and-ankle-surgery-compared-with-popliteal-sciatic-nerve-block-alone
#11
Young Uk Park, Jae Ho Cho, Doo Hyung Lee, Wan Sun Choi, Han Dong Lee, Keun Soo Kim
BACKGROUND: Single or combined multiple-site peripheral nerve blocks (PNBs) are becoming popular for patients undergoing surgery on their feet or ankles. These procedures are known to be generally safe in surgical settings compared with other forms of anesthesia, such as spinal block. The purposes of this study were to assess the incidence of complications after the administration of multiple PNBs for foot and ankle surgery and to compare the rates of complications between patients who received a single PNB and those who received multiple blocks...
January 1, 2018: Foot & Ankle International
https://www.readbyqxmd.com/read/29343466/long-term-cardiovascular-prognosis-after-transient-ischemic-attack-associated-predictors
#12
Angel Ois, Ana Zabalza, Antia Moreira, Elisa Cuadrado-Godia, Jordi Jimenez-Conde, Eva Giralt-Steinhauer, Ana Rodríguez-Campello, Carolina Soriano-Tarraga, Jaume Roquer
OBJECTIVE: To determine long-term cardiovascular risk after TIA and to identify the factors associated with increased risk. METHODS: This was a prospective observational registry of TIA patients admitted to the emergency room of our tertiary stroke center from June 2006 to January 2016. New vascular events (NVEs) were recorded from 3 months after TIA onset until June 2017, including both stroke and nonstroke events (coronary and peripheral disease). We registered TIA etiology, age, sex, vascular risk factors, radiologic data, and clinical TIA features and analyzed these variables in relation to NVE long-term risk...
January 17, 2018: Neurology
https://www.readbyqxmd.com/read/29339433/five-year-mortality-after-transient-ischemic-attack-focus-on-cardiometabolic-comorbidity-and-hospital-readmission
#13
Mohammed Yousufuddin, Nathan Young, Lawrence Keenan, Tammy Olson, Jessica Shultz, Taylor Doyle, Eimad M Ahmmad, Kogulavadanan Arumaithurai, Paul Takahashi, Mohammad Hassan Murad
BACKGROUND AND PURPOSE: We aimed at providing estimates of mortality associated with cardiometabolic comorbidity and incident readmission from cardiometabolic as compared with noncardiometabolic conditions after a first transient ischemic attack. METHODS: Between 2000 and 2015, patients hospitalized for a first transient ischemic attack were examined for cardiometabolic comorbidities (diabetes mellitus, coronary artery disease, heart failure, and atrial fibrillation), 5-year incident hospitalization, and time to death...
January 16, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29318456/voltage-dependence-of-the-ca2-transient-in-endocardial-and-epicardial-myocytes-from-the-left-ventricle-of-goto-kakizaki-type-2-diabetic-rats
#14
Lina Al Kury, Vadym Sydorenko, Manal M A Smail, Muhammad Anwar Qureshi, Anatoliy Shmygol, Murat Oz, Jaipaul Singh, Frank Christopher Howarth
Diabetes mellitus is a major global health disorder and, currently, over 450 million people have diabetes with 90% suffering from type 2 diabetes. Left untreated, diabetes may lead to cardiovascular diseases which are a leading cause of death in diabetic patients. Calcium is the trigger and regulator of cardiac muscle contraction and derangement in cellular Ca2+ homeostasis, which can result in heart failure and sudden cardiac death. It is of paramount importance to investigate the regional involvement of Ca2+ in diabetes-induced cardiomyopathy...
January 9, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29314873/2018-aaha-diabetes-management-guidelines-for-dogs-and-cats
#15
Ellen Behrend, Amy Holford, Patty Lathan, Renee Rucinsky, Rhonda Schulman
Diabetes mellitus (DM) is a common disease encountered in canine and feline medicine. The 2018 AAHA Diabetes Management Guidelines for Dogs and Cats revise and update earlier guidelines published in 2010. The 2018 guidelines retain much of the information in the earlier guidelines that continues to be applicable in clinical practice, along with new information that represents current expert opinion on controlling DM. An essential aspect of successful DM management is to ensure that the owner of a diabetic dog or cat is capable of administering insulin, recognizing the clinical signs of inadequately managed DM, and monitoring blood glucose levels at home, although this is ideal but not mandatory; all topics that are reviewed in the guidelines...
January 2018: Journal of the American Animal Hospital Association
https://www.readbyqxmd.com/read/29310992/interleukin-1-genotypes-modulate-the-long-term-effect-of-lipoprotein-a-on-cardiovascular-events-the-ioannina-study
#16
Katerina K Naka, Aris Bechlioullis, Aikaterini Marini, Dimitrios Sionis, Konstantinos Vakalis, Georgios Triantis, Leon Wilkins, John Rogus, Kenneth S Kornman, Joseph L Witztum, Lynn Doucette-Stamm, Lampros K Michalis, Sotirios Tsimikas
BACKGROUND: Lipoprotein(a) [Lp(a)] is a genetic risk factor for cardiovascular disease (CVD), and proinflammatory interleukin-1 (IL-1) genotypes may influence Lp(a)-mediated CVD events. The genotype IL-1(+) is associated with higher rates of inflammation than IL-1(-) genotype. Targeting IL-1β was recently shown to decrease CVD events independent of low-density lipoprotein-cholesterol levels. OBJECTIVE: The objective of the study is to assess the modulatory effect of IL-1 genotypes on risk mediated by Lp(a) METHODS: We assessed whether IL-1 genotypes modulate the effect of Lp(a) on major adverse cardiovascular events (cardiovascular death, myocardial infarction, and stroke/transient ischemic attack) and angiographically determined coronary artery disease (CAD)...
December 19, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29304513/nonvitamin-k-antagonist-oral-anticoagulants-use-in-patients-with-atrial-fibrillation-and-bioprosthetic-heart-valves-prior-surgical-valve-repair-a-multicenter-clinical-practice-experience
#17
Vincenzo Russo, Emilio Attena, Carmine Mazzone, Francesca Esposito, Valentina Parisi, Ciro Bancone, Anna Rago, Gerardo Nigro, Raffaele Sangiuolo, Antonio D' Onofrio
This is an observational study to investigate the efficacy and safety of nonvitamin K antagonist oral anticoagulants (NOACs) in atrial fibrillation (AF) patients with bioprosthetic valves or prior surgical valve repair in clinical practice. A total of 122 patients (mean age: 74.1 ± 13.2; 54 females) with bioprosthetic heart valve or surgical valve repair and AF treated with NOACs were included in the analysis. The mean CHA2DS2-VASc (Congestive heart failure, Hypertension, Age >75 years, Diabetes mellitus, prior Stroke or transient ischemic attack, Vascular disease) and HAS-BLED (Hypertension, Abnormal renal and liver function, Stroke, Bleeding, Labile INR [international normalized ratio], Elderly, Drugs or alcohol) score values were 3...
January 5, 2018: Seminars in Thrombosis and Hemostasis
https://www.readbyqxmd.com/read/29284738/comparison-of-risk-factor-control-in-the-year-after-discharge-for-ischemic-stroke-versus-acute-myocardial-infarction
#18
Dawn M Bravata, Joanne Daggy, Jared Brosch, Jason J Sico, Fitsum Baye, Laura J Myers, Christianne L Roumie, Eric Cheng, Jessica Coffing, Greg Arling
BACKGROUND AND PURPOSE: The Veterans Health Administration has engaged in quality improvement to improve vascular risk factor control. We sought to examine blood pressure (<140/90 mm Hg), lipid (LDL [low-density lipoprotein] cholesterol <100 mg/dL), and glycemic control (hemoglobin A1c <9%), in the year post-hospitalization for acute ischemic stroke or acute myocardial infarction (AMI). METHODS: We identified patients who were hospitalized (fiscal year 2011) with ischemic stroke, AMI, congestive heart failure, transient ischemic attack, or pneumonia/chronic obstructive pulmonary disease...
February 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29249611/actinic-keratosis-and-diabetes-complications-a-nationwide-population-based-study-in-south-korea-2009-2015
#19
Y Bok Lee, J Hyun Lee, J Young Choi, D Soo Yu, K Do Han, Y Gyu Park
AIM: As the associations between actinic keratosis (AK) and diabetes complications in patients with diabetes mellitus (DM) have never been investigated, this study aimed to evaluate any such associations in patients with DM. METHODS: This retrospective cohort study analyzed clinical data for DM patients aged>40 years who had undergone the health examination recommended by the South Korea National Health Insurance Program between 2009 and 2012 (n=2,056,580). All of these patients were classified according to the presence of diabetic retinopathy (DR), end-stage renal disease (ESRD) and history of DVD; myocardial infarction, stroke, transient ischaemic attacks...
November 29, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/29243834/outcome-of-octogenarians-with-atrial-fibrillation-undergoing-percutaneous-coronary-intervention-insights-from-the-afcas-registry
#20
Heli M Lahtela, Aissa Bah, Tuomas Kiviniemi, Wail Nammas, Axel Schlitt, Andrea Rubboli, Pasi P Karjalainen, Marco Proietti, Juha E K Hartikainen, Gregory Y H Lip, K E Juhani Airaksinen
BACKGROUND: More evidence is needed on the optimal antithrombotic regimen in elderly patients with atrial fibrillation (AF) undergoing percutaneous coronary intervention (PCI). HYPOTHESIS: Octogenarian patients (aged ≥80 years) with AF who underwent PCI have worse 12-month clinical outcome, compared with younger patients. METHODS: We performed a post-hoc analysis of data from the prospective, multicenter AFCAS registry, which enrolled consecutive patients with AF who underwent PCI and stenting...
December 15, 2017: Clinical Cardiology
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