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https://www.readbyqxmd.com/read/29917301/prevalence-and-prognostic-impact-of-non-cardiac-co-morbidities-in-heart-failure-outpatients-with-preserved-and-reduced-ejection-fraction-a-community-based-study
#1
Annamaria Iorio, Michele Senni, Giulia Barbati, Stephen J Greene, Stefano Poli, Elena Zambon, Concetta Di Nora, Giovanni Cioffi, Luigi Tarantini, Antonello Gavazzi, Gianfranco Sinagra, Andrea Di Lenarda
AIM: To assess adverse outcomes attributable to non-cardiac co-morbidities and to compare their effects by left ventricular ejection fraction (LVEF) group [LVEF <50% (heart failure with reduced ejection fraction, HFrEF), LVEF ≥50% (heart failure with preserved ejection fraction, HFpEF)] in a contemporary, unselected chronic heart failure population. METHODS AND RESULTS: This community-based cohort enrolled patients from October 2009 to December 2013. Adjusted hazard ratio (HR) and the population attributable fraction (PAF) were used to compare the contribution of 15 non-cardiac co-morbidities to adverse outcome...
June 19, 2018: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29917259/poor-sleep-quality-is-associated-with-nocturnal-glycemic-variability-and-fear-of-hypoglycemia-in-adults-with-type-1-diabetes
#2
Pamela Martyn-Nemeth, Shane A Phillips, Dan Mihailescu, Sarah S Farabi, Chang Park, Rebecca Lipton, Esema Idemudia, Laurie Quinn
AIMS: To examine sleep quality and its associations with glycemic control, glycemic variability and fear of hypoglycemia in adults with type 1 diabetes. BACKGROUND: Poor sleep quality has negative health consequences and is a frequent complaint among adults with type 1 diabetes. Sleep quality in adults with type 1 diabetes is likely affected by glucose levels as well as stressors associated with managing a chronic condition. DESIGN: A retrospective secondary analysis of pooled data from two previous cross-sectional studies was conducted...
June 19, 2018: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/29917249/exposure-to-hypoglycemia-and-risk-of-stroke
#3
REVIEW
Logan Smith, Diya Chakraborty, Pallab Bhattacharya, Deepaneeta Sarmah, Sebastian Koch, Kunjan R Dave
In the treatment of both type 1 and type 2 diabetes mellitus, maintaining a euglycemic state represents one of the key challenges. Improper dosing and administration of glucose-lowering drugs is associated with an increased risk of recurrent hypoglycemia episodes. In addition, the risk of adverse cardiovascular events in diabetic patients, particularly myocardial infarctions and strokes, is well established. Current research indicates a potential link between the baseline risk of cardio/cerebrovascular events in diabetic patients and exposure to hypoglycemia...
June 19, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29917217/oral-administration-of-a-curcumin-phospholipid-formulation-meriva%C3%A2-for-treatment-of-chronic-diabetic-macular-edema-a-pilot-study
#4
F Mazzolani, S Togni, L Giacomelli, R Eggenhoffner, F Franceschi
OBJECTIVE: The purpose of this open-label study was to investigate the effect of a curcumin-phospholipid lecithin formulation (Meriva®) on visual acuity and optical coherence tomography (OCT) retinal thickness in patients with chronic diabetic macular edema. PATIENTS AND METHODS: Curcumin-phospholipid lecithin formulation (Meriva®, Indena S.p.A, Milan, Italy) was administered as tablets (Norflo®, Eye Pharma, Genoa, Italy) twice a day. Visual acuity and macular edema as measured by OCT before and after curcumin-phospholipid formulation treatment were assessed...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29917205/efficacy-and-safety-of-dipeptidyl-peptidase-4-inhibitors-in-the-treatment-of-type-2-diabetes-mellitus-patients-with-moderate-to-severe-renal-impairment-a-meta-analysis
#5
Y Chen, K Men, X-F Li, J Li, M Liu, Z-Q Fan
OBJECTIVE: Dipeptidyl peptidase-4 (DPP-4) inhibitors are a new class of oral antidiabetic agents for type 2 diabetes mellitus (T2DM) patients. However, the effects and safety of DPP-4 inhibitors in T2DM patients with renal impairment (RI) remain controversial. Therefore, we conducted this meta-analysis to assess the efficacy and safety of DPP-4 inhibitors in T2DM patients with moderate to severe RI. MATERIALS AND METHODS: The PubMed, Embase, and Web of Science database were searched for published randomized controlled trials (RCTs), which compared DPP-4 inhibitors with placebo or a control regimen...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29917198/an-analysis-of-cognitive-functioning-of-children-and-youth-with-type-1-diabetes-t1dm-in-the-context-of-glycemic-control
#6
M Stanisławska-Kubiak, E Mojs, R W Wójciak, B Piasecki, M Matecka, J Sokalski, P Kopczyński, P Fichna
OBJECTIVE: The aim of the study was to evaluate the cognitive functioning of children and youth with type 1 diabetes (T1DM). PATIENTS AND METHODS: The study included 68 children with type 1 diabetes, aged 6-17 years, divided into 3 groups according to the level of glycated hemoglobin (HbA1c): group 1: HbA1c ≤ 6.0-7.5%; group 2: HbA1c 7.6-8.5%; group 3: HbA1c over 8.6%. Wechsler's intelligence scale (WISC-R), the Trail of 10 words and Brickenkamp's and Zillmer's d2 Test of Attention were used to assess cognitive functioning...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29917143/implementation-of-medication-related-indicators-of-potentially-preventable-hospitalizations-in-a-national-chronic-disease-management-program-for-older-patients-with-multimorbidity
#7
Gillian E Caughey, Jodie B Hillen, Stephanie Bacon, Nicholas Bullock, Virginia Bullock, Lisa Kalisch Ellett
Initial assessment: Older people are at increased risk of medication-related potentially preventable hospitalizations (MR-PPH) due to the presence of multiple chronic conditions (multimorbidity) and subsequent polypharmacy. Choice of solution: A pilot study was conducted, using evidence-based indicators to detect older patients in a chronic disease management program (CDMP) at risk of hospitalization due to sub-optimal medication use. Implementation: Previously validated indicators for MR-PPH were applied to patients with multimorbidity, aged 65 years or older and who were enrolled in a national community-based CDMP...
June 18, 2018: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29917105/pancreatic-cancer-following-incident-diabetes-in-african-americans-and-latinos-the-multiethnic-cohort
#8
Veronica Wendy Setiawan, Daniel O Stram, Jacqueline Porcel, Suresh T Chari, Gertraud Maskarinec, Loïc Le Marchand, Lynne R Wilkens, Christopher A Haiman, Stephen J Pandol, Kristine R Monroe
Background: Diabetes has been proposed to be a risk factor for and a consequence of pancreatic cancer (PC). The relationship between recent-onset diabetes and PC is not well understood, and data in minorities are sparse. We examined the relationships between recent-onset diabetes and PC incidence in African Americans and Latinos in the Multiethnic Cohort. Methods: A total of 48 995 African Americans and Latinos without prior diabetes and cancer at baseline (1993-1996) were included in the study...
June 18, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29917058/cross-sectional-association-of-frailty-and-arterial-stiffness-in-community-dwelling-older-adults-the-framingham-heart-study
#9
Ariela R Orkaby, Kathryn L Lunetta, Fangui J Sun, Jane A Driver, Emelia J Benjamin, Naomi M Hamburg, Gary F Mitchell, Ramachandran S Vasan, Joanne M Murabito
Background: Frailty is a risk factor for cardiovascular disease. Underlying mechanisms to explain the connection between frailty and cardiovascular disease are unclear. We sought to examine the association between frailty and arterial stiffness, a precursor of hypertension and cardiovascular disease. Methods: We conducted a cross-sectional analysis of community-dwelling Framingham Heart Study Offspring and Omni participants ≥60 years of age examined in 2005-2008...
June 18, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29917037/high-plasma-apolipoprotein-b-identifies-obese-subjects-who-best-ameliorate-white-adipose-tissue-dysfunction-and-glucose-induced-hyperinsulinemia-after-a-hypocaloric-diet
#10
Simon Bissonnette, Nathalie Saint-Pierre, Valerie Lamantia, Catherine Leroux, Viviane Provost, Yannick Cyr, Remi Rabasa-Lhoret, May Faraj
Background: To optimize the prevention of type 2 diabetes (T2D), high-risk obese subjects with the best metabolic recovery after a hypocaloric diet should be targeted. Apolipoprotein B lipoproteins (apoB lipoproteins) induce white adipose tissue (WAT) dysfunction, which in turn promotes postprandial hypertriglyceridemia, insulin resistance (IR), and hyperinsulinemia. Objective: The aim of this study was to explore whether high plasma apoB, or number of plasma apoB lipoproteins, identifies subjects who best ameliorate WAT dysfunction and related risk factors after a hypocaloric diet...
June 18, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29917009/clubfoot-etiology-a-meta-analysis-and-systematic-review-of-observational-and-randomized-trials
#11
Cynthia Chen, Neil Kaushal, David M Scher, Shevaun M Doyle, John S Blanco, Emily R Dodwell
BACKGROUND: Clubfoot is a common congenital anomaly with multiple potential risk factors. Identification of modifiable risk factors may minimize future incidence of clubfoot. The aim of this meta-analysis was to systematically review and analyze the best clinical evidence regarding risk factors associated with clubfoot. METHODS: Medline, Embase, and Cochrane databases were systematically searched from 1967 to May 11, 2016 for studies reporting risk factors for clubfoot...
June 18, 2018: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29917004/is-female-sex-an-independent-risk-factor-for-early-mortality-in-isolated-coronary-artery-bypass-graft-a-propensity-matched-analysis
#12
Andrea Garatti, Alessandro Parolari, Alberto Canziani, Eugenio Mossuto, Andrea Daprati, Ali Abu Farah, Daniele Brugnetti, Marco Ranucci, Lorenzo Menicanti
AIMS: Despite several studies reporting a higher mortality rate for women undergoing isolated coronary artery bypass graft (CABG) surgery, this issue has not been completely clarified. The aim of the current study was to determine if sex differences in CABG surgery affect adjusted operative results and operative mortality. METHODS: Between January 2005 and December 2012, 3756 consecutive patients (3009 men and 747 women) underwent isolated CABG at our institution...
June 16, 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29916924/how-to-best-assess-abdominal-obesity
#13
Hongjuan Fang, Elizabeth Berg, Xiaoguang Cheng, Wei Shen
PURPOSE OF REVIEW: Abdominal obesity, especially the increase of visceral adipose tissue (VAT), is closely associated with increased mortality related to cardiovascular disease, diabetes, and fatty liver disease. This review provides an overview of the recent advances for abdominal obesity measurement. RECENT FINDINGS: Compared to simple waist circumference, emerging three-dimensional (3D) body-scanning techniques also measure abdominal volume and shape. Abdominal dimension measures have been implemented in bioelectrical impedance analysis to improve accuracy when estimating VAT...
June 18, 2018: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/29916880/prospective-creation-and-validation-of-the-preventt-prediction-and-enaction-of-prevention-treatments-trigger-scale-for-surgical-site-infections-ssis-in-patients-with-diverticulitis
#14
Liliana Bordeianou, Christy E Cauley, Ruchin Patel, Ronald Bleday, Sadiqa Mahmood, Kevin Kennedy, Khawaja F Ahmed, Deborah Yokoe, David Hooper, Marc Rubin
OBJECTIVE: Create and validate diverticulitis surgical site infection prediction scale. BACKGROUND: Surgical site infections cause significant morbidity after colorectal surgery. An infection prediction scale could target infection prevention bundles to high-risk patients. METHODS: Prospectively collected National Surgical Quality Improvement Program and electronic medical record data obtained on diverticulitis colectomy patients across a Healthcare Network-wide Colorectal Surgery Collaborative (5 hospitals)...
June 18, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29916858/nonalcoholic-fatty-liver-disease-and-hypertension-coprevalent-or-corelated
#15
Dimitrios Oikonomou, Georgios Georgiopoulos, Vassiliki Katsi, Chris Kourek, Constantinos Tsioufis, Alexendra Alexopoulou, Evaggelia Koutli, Dimitrios Tousoulis
OBJECTIVE: To provide a comprehensive review summarizing the existing evidence on the association between nonalcoholic fatty liver disease (NAFLD) and hypertension (HT) independent of other components of metabolic syndrome. METHODS: We searched the literature through Medline and the Cochrane Library for studies evaluating the relationship between hypertension and fatty liver disease. RESULTS: Studies testing this association are limited, but agree that HT and fatty liver disease are inter-related independent of other components of the metabolic syndrome such as obesity and diabetes mellitus...
June 18, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29916848/pancreas-transplantation-in-type-2-diabetes-expanding-the-criteria
#16
Talal M Al-Qaoud, Jon S Odorico, Robert R Redfield
PURPOSE OF REVIEW: Pancreas transplantation in type 2 diabetes mellitus (T2DM) candidates remains disproportionately lower than in type 1 diabetes mellitus (T1DM); however, outcomes in carefully selected patients mirrors that of T1DM. Despite the 2014 United Network for Organ Sharing (UNOS) eligibility criteria for simultaneous pancreas/kidney transplant (SPK) transplantation in T2DM patients, an expected increase in the number of transplants was not observed. RECENT FINDINGS: In an updated International Pancreas and Transplant Registry (IPTR) analysis, 1514 primary deceased donor pancreas transplants were performed in T2DM recipients [1995-2015, SPK 88%, pancreas after kidney (PAK) 9%, pancreas transplant alone (PTA) 3%]...
June 18, 2018: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/29916766/early-life-displacement-due-to-armed-conflict-and-violence-early-nutrition-and-older-adult-hypertension-diabetes-and-obesity-in-the-middle-income-country-of-colombia
#17
Mary McEniry, Rafael Samper-Ternent, Carmen Elisa Flórez, Carlos Cano-Gutierrez
OBJECTIVE: We examine the importance of early life displacement and nutrition on hypertension (HTN) and diabetes in older Colombian adults (60+ years) exposed to rapid demographic, epidemiological, and nutritional transitions, and armed conflict. We compare early life nutritional status and adult health in other middle- and high-income countries. METHOD: In Colombia (Survey of Health, Wellbeing and Aging [SABE]-Bogotá), we estimate the effects of early life conditions (displacement due to armed conflict and violence, hunger, low height, and not born in the capital city) and obesity on adult health; we compare the effects of low height on adult health in Mexico, South Africa (Study on Global Ageing and Adult Health [SAGE]), the United States, and England (Health and Retirement Study [HRS], English Longitudinal Study of Ageing [ELSA])...
June 1, 2018: Journal of Aging and Health
https://www.readbyqxmd.com/read/29916742/glucose-variability-a-review-of-clinical-applications-and-research-developments
#18
David Rodbard
Glycemic variability (GV) is a major consideration when evaluating quality of glycemic control. GV increases progressively from prediabetes through advanced T2D and is still higher in T1D. GV is correlated with risk of hypoglycemia. The most popular metrics for GV are the %Coefficient of Variation (%CV) and standard deviation (SD). The %CV is correlated with risk of hypoglycemia. Graphical display of glucose by date, time of day, and day of the week, and display of simplified glucose distributions showing % of time in several ranges, provide clinically useful indicators of GV...
June 2018: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29916741/combined-sglt1-and-sglt2-inhibitors-and-their-role-in-diabetes-care
#19
Thomas Danne, Torben Biester, Olga Kordonouri
The sodium-glucose cotransporter type 1 (SGLT1) is the primary transporter for absorption of glucose and galactose in the gastrointestinal tract. Inhibition blunts and delays postprandial glucose (PPG) excursion. Sodium-glucose cotransporter type 2 (SGLT2) is expressed in the kidney, where it reabsorbs 90% of filtered glucose. Thus, a dual SGLT1 and SGLT2 inhibition (compared with selective SGLT2 inhibition) could result in lower PPG and robust A1c reduction even in patients with reduced kidney function. Sotagliflozin is an oral potent dual inhibitor of the insulin-independent SGLT1 and SGLT2...
June 2018: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29916740/preserving-skin-integrity-with-chronic-device-use-in-diabetes
#20
Laurel H Messer, Cari Berget, Christie Beatson, Sarit Polsky, Gregory P Forlenza
Skin integrity and diabetes device placement are ongoing concerns for people with diabetes who utilize continuous glucose monitors (CGMs) and continuous subcutaneous insulin infusion pumps. This is especially significant for individuals with skin sensitivities, pediatric patients, and those who use devices chronically. Dermatological complications are often cited as a barrier to device use and a reason for device discontinuation. Furthermore, it is a frequent topic of discussion in diabetes follow-up visits, although little evidence-based literature exists to guide providers in managing skin integrity issues...
June 2018: Diabetes Technology & Therapeutics
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