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Analúcia Abreu Maranhão, Marcia Maria Jardim Rodrigues, Sonia Regina da Silva Carvalho, Marcelo Ribeiro Caetano, Inaê Mattoso Compagnoni, Tatiana Catia Carnio, Débora Ribeiro
Objective The aim of this study was to obtain data on phrenic neuroconduction and electromyography of the diaphragm muscle in difficult-to-treat asthmatic patients and compare the results to those obtained in controls. Methods The study consisted of 20 difficult-to-treat asthmatic patients compared with 27 controls. Spirometry, maximal inspiratory and expiratory pressure, chest X-ray, phrenic neuroconduction and diaphragm electromyography data were obtained. Results The phrenic compound motor action potential area was reduced, compared with controls, and all the patients had normal diaphragm electromyography...
March 2018: Arquivos de Neuro-psiquiatria
Heidi R H Zupanc, Peter G Alexander, Rocky S Tuan
BACKGROUND: Adult mesenchymal stem cells (MSCs) have been shown to increase nerve regeneration in animal models of nerve injury. Traumatized muscle-derived multipotent progenitor cells (MPCs) share important characteristics with MSCs and are isolated from severely damaged muscle tissue following surgical debridement. Previous investigations have shown that MPCs may be induced to increase production of several neurotrophic factors, suggesting the possible utility of autologous MPCs in peripheral nerve regeneration following injury...
October 13, 2017: Stem Cell Research & Therapy
Alan J Ryan, William A Lackington, Alan J Hibbitts, Austyn Matheson, Tijna Alekseeva, Anna Stejskalova, Phoebe Roche, Fergal J O'Brien
Clinically available hollow nerve guidance conduits (NGCs) have had limited success in treating large peripheral nerve injuries. This study aims to develop a biphasic NGC combining a physicochemically optimized collagen outer conduit to bridge the transected nerve, and a neuroconductive hyaluronic acid-based luminal filler to support regeneration. The outer conduit is mechanically optimized by manipulating crosslinking and collagen density, allowing the engineering of a high wall permeability to mitigate the risk of neuroma formation, while also maintaining physiologically relevant stiffness and enzymatic degradation tuned to coincide with regeneration rates...
December 2017: Advanced Healthcare Materials
Sandra M Barrera-Castro, Fernando Ortiz-Corredor
OBJECTIVE: Establishing reference values for neuroconduction studies regarding the peroneal, tibial and sural nerves in a group of young adults. MATERIALS AND METHODS: Neuroconduction was tested (also known as nerve conduction velocity (NCV) tests) on 155 asymptomatic subjects' tibial, peroneal and sural nerves using current conventional techniques, after informed written consent had been obtained. Reference values were obtained and presented as averages, standard deviations and percentiles, along with their correlation with parameters such as age, weight and height, via bivariate analysis of linear correlation using Spearman's rank correlation test...
May 2014: Revista de Salud Pública
Joaquim Casañas, Jaime de la Torre, Francesc Soler, Felix García, Clementina Rodellar, Martí Pumarola, Jana Climent, Robert Soler, Lluís Orozco
The standard treatment of peripherical nerve injuries with substance gap is to introduce the nerve free extremes in a biodegradable tube which, as a biocamera, allows the continuity of the nerve, promote the neuroconduction and save the lesion from the surrounding fibrosis. However, this procedure has not any direct effect on the neuroregeneration nor to resolve high severe lesions. The mesenchymal stem cells (MSC) can derivate "in vitro" in different lineages, including Schwann cells. Different studies have shown MSC can promote the nerve regeneration in rodents, dogs and primates...
October 2014: Injury
Hugo Sánchez, Cecilia Albala, Lydia Lera, José Luis Castillo, Renato Verdugo, Manuel Lavados, Eva Hertrampf, Alex Brito, Lindsay Allen, Ricardo Uauy
BACKGROUND: Older people have a high risk of vitamin B12 deficiency; this can lead to varying degrees of cognitive and neurological impairment. CBL deficiency may present as macrocytic anemia, subacute combined degeneration of the spinal cord, or as neuropathy, but is often asymptomatic in older people. Less is known about subclinical vitamin B12 deficiency and concurrent neuroconduction and cognitive impairment. A Programme of Complementary Feeding for the Older Population (PACAM) in Chile delivers 2 complementary fortified foods that provide approximately 1...
2011: Nutrition Journal
L M Murillo-Bonilla, C Mendez-Gonzalez, B Alvarez, C Ramirez
CASE REPORT: We report the case of a 37-year-old male who presented signs of acute motor axonal polyradiculoneuropathy that began three weeks after a three-day bout of gastroenteritis and was accompanied by a stiff neck, hyperreflexia and anti-GA1 antibodies. The symptoms developed within 12 hours, after beginning with the patient waking up in the middle of the night with a headache; the following morning he presented general weakness and cranial neuropathy and therefore decided to go to hospital...
March 1, 2011: Revista de Neurologia
Mónica Lizarralde, Sara Helena Gutiérrez, Adriana Venegas
UNLABELLED: BACKGROUND; Allergan Inc. recommends that its botulinum toxin type A (BTX-A; BOTOX) must be refrigerated and applied within 4 hours after its reconstitution to avoid losing its biologic effectiveness. OBJECTIVE: The objective was to compare clinical efficacy in treating external canthus dynamic lines with reconstituted and refrigerated toxin (BTX-A) 1 week before its application versus fresh toxin (BTX-A). METHODS: This study was a double-blind, randomized, clinical trial...
November 2007: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
S M Jazayeri Shooshtari, D Didehdar, A R Moghtaderi Esfahani
BACKGROUND: Lower limb injuries and ankle sprain occur frequently among football players, due to the high incidence of physical contact. As a result, lower limb nerves are subject to injury. This project aims to evaluate the lower limb nerve conduction among students playing football to investigate the probable relationship between ankle sprain in football and nerve conductivity. MATERIALS AND METHODS: Fifty volunteer students aged between 19 and 25 were studied...
September 2007: Electromyography and Clinical Neurophysiology
M C Buompadre, L A Gáñez, M Miranda, H A Arroyo
AIMS: To identify unusual variants within a paediatric population of patients with Guillain-Barré syndrome (GBS), to determine the frequency of their occurrence and to describe their clinical and electrophysiological characteristics. PATIENTS AND METHODS: The medical records of 179 patients diagnosed with GBS were reviewed. Those who strictly satisfied the Asbury criteria were excluded. RESULTS: Twenty patients, with a mean age of 7.6 years at the onset of symptoms, presented the following clinical variants: multiple cranial polyneuropathy (4 cases), Miller Fisher syndrome (MFS) (3 cases), pharyngeal-cervical-brachial palsy (PCBP) (2 cases), combined MFS and PCBP (3 cases), paraparesis (4 cases), palpebral ptosis without ophthalmoplegia (1 case), ophthalmoplegia without ataxia (1 case), paresis of the abducent nerve with paresthesias (1 case), and saltatory (1 case)...
January 16, 2006: Revista de Neurologia
Irene Orozco-De Los Ríos, Pedro Miguel Sánchez-Vizcaíno, Diego González-Ramírez, José García-Piñón
OBJECTIVE: To analyze the relationship between the chronic exposure (EC) to organophosphated insecticides (IOF) with the presence of peripheral neuropathy (NP) and the deterioration of cognitive functions (DFC). DESIGN OF THE STUDY: Cross-section, comparative and observational. MATERIAL AND METHODS: Workers with more than three months of seniority, who participated in any stage of the process of production of IOF were included, and those with alterations in the neurological function were excluded...
November 2005: Revista Médica del Instituto Mexicano del Seguro Social
Armando Mansilla-Olivares
Although during the last three decades phosphorylation and dephosphorylation systems have been pointed out as the mechanisms used by living cells to control biological processes, it seems that calcium dynamics is the phenomenon that precedes and controls protein activation by the introduction of phosphate groups into distinct protein structures. The process begins with activation of calcium channels that allows the influx of the ion, which once inside the cell leads to calcium-calmodulin complex, a molecule capable of triggering activation of distinct proteinkinases...
March 2004: Cirugia y Cirujanos
F Ortiz Corredor
INTRODUCTION: Guillain Barré syndrome (GBS) is the most frequent cause of acute flaccid paralysis in children. The factors that come to bear on its prognosis have not been properly determined in Latin America. AIMS: Our aim was to establish the clinical and electrophysiological indicators of GBS in a group of paediatric patients attended in a tertiary care hospital. Patients and methods. We conducted a prospective study involving 67 patients who were hospitalised in the Instituto de Ortopedia Infantil Roosevelt between 1999 and 2002 after having been diagnosed as suffering from GBS...
March 16, 2004: Revista de Neurologia
C Viera Alemán, E Purón, M L Hamilton, C Santos Anzorandia, A Navarro, I Pineda Ortiz
INTRODUCTION: The treatment selection in the carpal tunnel syndrome according to the damage of the median nerve is important and all of these have adverse effects. A good alternative without undesired reactions is irradiation of the carpal tunnel with not coherent light between 920 and 940 nm emitted by gallium arsenide diodes, resembling the physic and therapeutic laser effects. PATIENTS AND METHODS: Twenty-six female patients with idiopathic middle carpal tunnel syndrome were irradiated 15 minutes daily during three weeks...
April 16, 2001: Revista de Neurologia
J H Gutiérrez Ronquillo, R Andrade Machado, A Machado Rojas, A García Espinosa
INTRODUCTION: Multifocal motor neuropathy with partial conduction block is characterized by being a chronic, demyelinating, autoimmune severely disabling neuropathy. In Cuba three cases were reported by Dr. Estrada et al in 1999. This neuropathy presents clinically in relatively young persons. The arms are predominantly affected and the typical signs are of severe asymmetrical weakness, with atrophy which is less marked than the weakness, fasciculations, cramps and myokymiae of the affected muscle...
March 1, 2001: Revista de Neurologia
W Sendoh, K Higami, M Harigai, J Matsumoto, Y Nanke, Y Nakanishi, S Kotake, C Terai, H Kondo, M Takeuchi, M Hara, N Kamatani
A 66-year-old female was admitted to our hospital in January, 1998, complaining of low grade fever and muscle weakness of her legs. Physical examination revealed muscle weakness of her neck (4/5) and proximal skeletal muscles of her bilateral legs (3/5-4/5). She showed proteinuria and microhematuria. Her serum levels of ureanitrogen, creatinine, aspartate aminotransferase, alanine aminotransferase, creatinekinase, aldolase and myoglobin were all within the normal ranges. Antinuclear antibodies were negative, but her serum levels of pANCA (743 EU) and C reactive protein (18...
October 1999: Ryūmachi. [Rheumatism]
S Woerly, P Petrov, E Syková, T Roitbak, Z Simonová, A R Harvey
A biocompatible heterogeneous hydrogel of poly [N-(2-hydroxypropyl) methacrylamide] (PHPMA), was evaluated for its ability to promote tissue repair and enhance axonal regrowth across lesion cavities in the brain and spinal cord in adult and juvenile (P17 P21) rats. Incorporation of PHPMA hydrogels into surrounding host tissue was examined at the ultrastructural level and using immunohistochemical techniques. In addition, and in parallel to these studies, diffusion parameters (volume fraction and tortuosity of the gel network) of the PHPMA hydrogels were evaluated pre- to postimplantation using an in vivo real-time iontophoretic method...
October 1999: Tissue Engineering
M V Perea, V Ladera, A Blanco, F Morales
INTRODUCTION AND OBJECTIVE: We present a diagnostic decision tree for the correct use of neuropsychological evaluation techniques in head injury. Our aim is to avoid extensive, intensive use of unnecessary tests and measurements or lapses into diagnostic error which often accompany cognitive dysfunction when 'superficial' 'undirected' studies are done. DEVELOPMENT: It is essential to select the neuropsychological, neuroconductal and psychosocial evaluation tests which are most suitable in each case and establish a reliable diagnosis of the functional, cognitive, emotional and psychosocial conditions of the patient...
May 16, 1999: Revista de Neurologia
C Viera, C Gálvez, B Carrasco, C Santos, R Castellanos
INTRODUCTION: There are some occlusive disorders in the vasa nervorum and metabolic changes disminishing oxygen liberation by erytrocites at the capillary blood vessels, and these disturbances lead to endoneural microhypoxia. Hyperbaric oxygen reverts hypoxia in the diabetic neuropathy. OBJECTIVE: We studied motor and sensitive peripheric neuroconduction in nine diabetic patients, with distal symmetrical polyneuropathy, during normoglycemia. Four of them were insulin dependent and five were non insulin dependent...
May 1, 1999: Revista de Neurologia
T Osuga, H Tatsuoka
The bullfrog sciatic nerve within six hours after extraction was determined from the change with time in the action potential and the impedance to be a partially active nerve. Steady magnetic fields have been determined to be ineffective in the neuroconduction in the fresh nerve just after extraction. Although ion motions involved in the neuroconduction in the partially active nerve are not normal, it was confirmed that a 1.5 T steady magnetic field is ineffective in the neuroconduction in the partially active nerve...
June 1999: Magnetic Resonance Imaging
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