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https://www.readbyqxmd.com/read/27914293/diethylcarbamazine-attenuates-lps-induced-acute-lung-injury-in-mice-by-apoptosis-of-inflammatory-cells
#1
Ingrid Tavares Fragoso, Edlene Lima Ribeiro, Fabiana Oliveira Dos Santos Gomes, Mariana Aragão Matos Donato, Amanda Karolina Soares Silva, Amanda Costa O de Oliveira, Shyrlene Meiry da Rocha Araújo, Karla Patrícia Sousa Barbosa, Laise Aline Martins Santos, Christina Alves Peixoto
BACKGROUND: Acute lung injury (ALI) is characterized by extensive neutrophil infiltration, and apoptosis delay considered part of the pathogenesis of the condition. Despite great advances in treatment strategies, few effective therapies are known for ALI. Diethylcarbamazine (DEC) is used against lymphatic filariasis, a number of studies have described its anti-inflammatory activities and pro-apoptotic effect. These properties have been associated with nuclear factor kappa-B inactivation...
September 24, 2016: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/27913826/partial-gene-sequencing-of-cyp1a-vitellogenin-and-metallothionein-in-mosquitofish-gambusia-yucatana-and-gambusia-sexradiata
#2
Roberto Vázquez-Euán, Karla S Escalante-Herrera, Gabriela Rodríguez-Fuentes
Ground characteristics in the Yucatan Peninsula make recovery and treatment of wastewater very expensive. This situation has contributed to an increase of pollutants in the aquifer. Unfortunately, studies related to the effects of those pollutants in native organisms are scarce. The aim of this work was to obtain partial sequences of widely known genes used as biomarkers of pollutant effect in Gambusia yucatana and Gambusia sexradiata. The studied genes were: cytochrome P450 1A (CYP1A); vitellogenin (VTG); metallothionein (MT), and two housekeeping genes, 18S and β-actin...
December 2, 2016: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/27913373/mobile-phone-apps-to-improve-medication-adherence-a-systematic-stepwise-process-to-identify-high-quality-apps
#3
Karla Santo, Sarah S Richtering, John Chalmers, Aravinda Thiagalingam, Clara K Chow, Julie Redfern
BACKGROUND: There are a growing number of mobile phone apps available to support people in taking their medications and to improve medication adherence. However, little is known about how these apps differ in terms of features, quality, and effectiveness. OBJECTIVE: We aimed to systematically review the medication reminder apps available in the Australian iTunes store and Google Play to assess their features and their quality in order to identify high-quality apps...
December 2, 2016: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/27912912/passive-air-sampling-of-persistent-organic-pollutants-pops-and-emerging-compounds-in-kolkata-megacity-and-rural-mangrove-wetland-sundarban-in-india-an-approach-to-regional-monitoring
#4
Karla Pozo, Santosh Kumar Sarkar, Victor H Estellano, Soumita Mitra, Ondrej Audi, Petr Kukucka, Petra Přibylová, Jana Klánová, Simonetta Corsolini
Polyurethane foam (PUF) disk passive air samplers were deployed concurrently at five sites across Kolkata megacity and the rural mangrove wetland of Sundarban (UNESCO World Heritage Site) between January-March in 2014. Samples were analyzed for hexachlorocyclohexanes (HCHs), dichlorodiphenyltricholoroethanes (DDTs), polychlorinated biphenyls (PCBs) and, polybrominated diphenyl ethers (PBDEs) using gas chromatography and mass spectrometry (GC-MS). Derived air concentrations (pg/m(3)) for Kolkata ranged: for ∑α- and γ-HCH between 70 and 207 (114 ± 62), ∑6DDTs: 127-216 (161 ± 36), ∑7PCBs: 53-213 (141 ± 64), and ∑10PBDEs: 0...
November 29, 2016: Chemosphere
https://www.readbyqxmd.com/read/27912042/the-prevalence-and-risks-for-depression-and-anxiety-in-hospice-caregivers
#5
Debra Parker Oliver, Karla Washington, Jamie Smith, Aisha Uraizee, George Demiris
BACKGROUND: Depression and anxiety are common concerns for hospice caregivers. OBJECTIVE: This study looked at the prevalence and variables associated with hospice caregiver depression and anxiety, as well as the relationship between the two conditions. SUBJECTS: We did a secondary analysis of preexisting data. MEASUREMENTS: Measures included the PHQ-9 and GAD-7. RESULTS: Nearly one-quarter of caregivers were moderately to severely depressed, and nearly one-third reported moderate to severe symptoms of anxiety...
December 2, 2016: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/27910171/results-of-computed-tomography-in-dogs-with-suspected-wooden-foreign-bodies
#6
Christopher R Lamb, Elizabeth H W Pope, Karla C L Lee
Detection of wooden foreign bodies in dogs can be challenging. A retrospective, cross-sectional study was done to describe computed tomographic (CT) signs associated with wooden foreign bodies, and to estimate the accuracy of CT for detection of wooden foreign bodies. Patient records and CT images were reviewed for 72 dogs that had a history of suspected stick injury and CT of the affected body part, or possible wooden foreign object reported on CT, and had surgical exploration during the same period of hospitalization...
December 1, 2016: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/27906869/early-and-sustained-vasopressin-infusion-augments-the-hemodynamic-efficacy-of-restrictive-fluid-resuscitation-and-improves-survival-in-a-liver-laceration-model-of-hemorrhagic-shock
#7
Raúl J Gazmuri, Kasen Whitehouse, Kruti Shah, Karla Whittinghill, Alvin Baetiong, Jeejabai Radhakrishnan
BACKGROUND: Current management of hemorrhagic shock favors restrictive fluid resuscitation before control of the bleeding source. We investigated the additional effects of early and sustained vasopressin infusion in a swine model of hemorrhagic shock produced by liver laceration. METHODS: Forty male domestic pigs (32 to 40 kg) had a liver laceration inflicted with an X-shaped blade clamp, 32 received a second laceration at minute 7.5, and 24 received two additional lacerations at minute 15...
November 30, 2016: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/27905853/surprising-results-from-an-angiotensin-converting-enzyme-inhibitor-trial-in-patients-with-chronic-obstructive-pulmonary-disease
#8
Karla V Ballman
No abstract text is available yet for this article.
December 1, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27900559/upregulated-tnf-expression-1%C3%A2-year-after-bariatric-surgery-reflects-a-cachexia-like-state-in-subcutaneous-adipose-tissue
#9
Alexander Jürets, Bianca Karla Itariu, Magdalena Keindl, Gerhard Prager, Felix Langer, Viktor Grablowitz, Maximilian Zeyda, Thomas Michael Stulnig
BACKGROUND: Adipose tissue dysfunction contributes to obesity-associated chronic diseases. In the first year after bariatric surgery, obese patients significantly improve their metabolic status upon losing weight. We aimed to investigate whether changes in subcutaneous adipose tissue gene expression reflect a restoration of a healthy lean phenotype after bariatric surgery. METHODS: Thirty-one severely obese patients (BMI ≥ 40 kg/m(2)) were examined before and after surgery...
November 29, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27895716/widespread-recovery-of-methylation-at-gametic-imprints-in-hypomethylated-mouse-stem-cells-following-rescue-with-dnmt3a2
#10
Avinash Thakur, Sarah-Jayne Mackin, Rachelle E Irwin, Karla M O'Neill, Gareth Pollin, Colum Walsh
BACKGROUND: Imprinted loci are paradigms of epigenetic regulation and are associated with a number of genetic disorders in human. A key characteristic of imprints is the presence of a gametic differentially methylated region (gDMR). Previous studies have indicated that DNA methylation lost from gDMRs could not be restored by DNMT1, or the de novo enzymes DNMT3A or 3B in stem cells, indicating that imprinted regions must instead undergo passage through the germline for reprogramming. However, previous studies were non-quantitative, were unclear on the requirement for DNMT3A/B and showed some inconsistencies...
2016: Epigenetics & Chromatin
https://www.readbyqxmd.com/read/27894725/occurrence-of-antiparasitic-pesticides-in-sediments-near-salmon-farms-in-the-northern-chilean-patagonia
#11
Felipe Tucca, Heriberto Moya, Karla Pozo, Francesca Borghini, Silvano Focardi, Ricardo Barra
Growth of the aquaculture industry has triggered the need for research into the potential environmental impact of chemicals used by salmon farms to control diseases. In this study, the antiparasitic pesticides emamectin benzoate (EB), diflubenzuron (DI), teflubenzuron (TE), and cypermethrin (CP) were measured in sediments near salmon cages in southern Chile. Concentrations for EB were between 2.2 and 14.6ngg(-1), while the benzoylphenyl ureas DI and TE were detected in the ranges of 0.1 to 1.2ngg(-1) and 0...
November 25, 2016: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/27892656/cytochrome-p450-bioconjugate-as-a-nanovehicle-for-improved-chemotherapy-treatment
#12
Katrin Quester, Karla Juarez-Moreno, Isamel Secundino, Yvonne Roseinstein, Karla P Alejo, Alejandro Huerta-Saquero, Rafael Vazquez-Duhalt
Cancer is still a growing public health problem, especially breast cancer that is one of the most important cancers in women. Chemotherapy, even though a successful treatment, is accompanied by severe side effects. Moreover, most of the drugs used for chemotherapy are administered as prodrugs and need to be transformed to the active form by cytochromes P450 (CYPs). In addition, increasing numbers of cancer tissues show lower CYP activity than the surrounding healthy tissues in which prodrugs are preferentially activated causing cytotoxicity...
November 28, 2016: Macromolecular Bioscience
https://www.readbyqxmd.com/read/27889522/increased-sink-strength-offsets-the-inhibitory-effect-of-sucrose-on-sugarcane-photosynthesis
#13
Rafael V Ribeiro, Eduardo C Machado, José R Magalhães Filho, Ana Karla M Lobo, Márcio O Martins, Joaquim A G Silveira, Xinyou Yin, Paul C Struik
Spraying sucrose inhibits photosynthesis by impairing Rubisco activity and stomatal conductance (gs), whereas increasing sink demand by partially darkening the plant stimulates sugarcane photosynthesis. We hypothesized that the stimulatory effect of darkness can offset the inhibitory effect of exogenous sucrose on photosynthesis. Source-sink relationship was perturbed in two sugarcane cultivars by imposing partial darkness, spraying a sucrose solution (50mM) and their combination. Five days after the onset of the treatments, the maximum Rubisco carboxylation rate (Vcmax) and the initial slope of A-Ci curve (k) were estimated by measuring leaf gas exchange and chlorophyll fluorescence...
November 18, 2016: Journal of Plant Physiology
https://www.readbyqxmd.com/read/27889478/sequential-enzymatic-saccharification-and-fermentation-of-ionic-liquid-and-organosolv-pretreated-agave-bagasse-for-ethanol-production
#14
Jose A Pérez-Pimienta, Alejandra Vargas-Tah, Karla M López-Ortega, Yessenia N Medina-López, Jorge A Mendoza-Pérez, Sayeny Avila, Seema Singh, Blake A Simmons, Inés Loaces, Alfredo Martinez
Agave bagasse (AGB) has gained recognition as a drought-tolerant biofuel feedstock with high productivity in semiarid regions. A comparative analysis of ionic liquid (IL) and organosolv (OV) pretreatment technologies in AGB was performed using a sequential enzymatic saccharification and fermentation (SESF) strategy with cellulolytic enzymes and the ethanologenic Escherichia coli strain MS04. After pretreatment, 86% of xylan and 45% of lignin were removed from OV-AGB, whereas IL-AGB reduced lignin content by 28% and xylan by 50% when compared to the untreated biomass...
November 16, 2016: Bioresource Technology
https://www.readbyqxmd.com/read/27887804/the-effect-of-photobiomodulation-on-chemotherapy-induced-peripheral-neuropathy-a-randomized-sham-controlled-clinical-trial
#15
Peter A Argenta, Karla V Ballman, Melissa A Geller, Linda F Carson, Rahel Ghebre, Sally A Mullany, Deanna G K Teoh, Boris J N Winterhoff, Colleen L Rivard, Britt K Erickson
BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of cancer therapy with few efficacious treatments. METHODS: We enrolled 70 patients with CIPN in a randomized, double-blinded, sham-controlled, cross-over trial to determine if photobiomodulation (PBM)±physiotherapy reduced the symptoms of neuropathy compared to sham treatment. At the conclusion of follow-up, sham-arm patients could cross-over into a third arm combining PBM and physiotherapy to determine if multimodal treatment had additive effects...
November 22, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27882235/intraoperative-molecular-analysis-of-sentinel-lymph-nodes-following-neoadjuvant-chemotherapy-in-patients-with-clinical-node-negative-breast-cancer-an-institutional-study
#16
David Parada, Karla B Peña, F Francesc Riu, A Esther Aguilar, Sebastian Cohan
Sentinel lymph node biopsy (SLNB) is an accurate, safe method for determining the axillary lymph node status. However, insufficient evidence exists to support the recommendation of SLNB in patients who have had neoadjuvant chemotherapy (NAC) to downsize tumours and allow for breast conservation surgery. The present study aimed to use molecular approaches to evaluate the feasibility and accuracy of SLNB in patients treated with NAC prior to SLN mapping and surgery. A total of 50 consecutive patients with operable invasive breast carcinomas who had received prior NAC were assessed using the one-step nucleic acid amplification (OSNA) method...
November 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27881746/neotropical-wrens-learn-new-duet-rules-as-adults
#17
Karla D Rivera-Cáceres, Esmeralda Quirós-Guerrero, Marcelo Araya-Salas, William A Searcy
Although song development in songbirds has been much studied as an analogue of language development in humans, the development of vocal interaction rules has been relatively neglected in both groups. Duetting avian species provide an ideal model to address the acquisition of interaction rules as duet structure involves time and pattern-specific relationships among the vocalizations from different individuals. In this study, we address the development of the most striking properties of duets: the specific answering rules that individuals use to link their own phrase types to those of their partners (duet codes) and precise temporal coordination...
November 30, 2016: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/27880844/atorvastatin-improves-ventricular-remodeling-after-myocardial-infarction-by-interfering-with-collagen-metabolism
#18
Karla Reichert, Helison Rafael Pereira do Carmo, Anali Galluce Torina, Daniela Diógenes de Carvalho, Andrei Carvalho Sposito, Karlos Alexandre de Souza Vilarinho, Lindemberg da Mota Silveira-Filho, Pedro Paulo Martins de Oliveira, Orlando Petrucci
PURPOSE: Therapeutic strategies that modulate ventricular remodeling can be useful after acute myocardial infarction (MI). In particular, statins may exert effects on molecular pathways involved in collagen metabolism. The aim of this study was to determine whether treatment with atorvastatin for 4 weeks would lead to changes in collagen metabolism and ventricular remodeling in a rat model of MI. METHODS: Male Wistar rats were used in this study. MI was induced in rats by ligation of the left anterior descending coronary artery (LAD)...
2016: PloS One
https://www.readbyqxmd.com/read/27880791/common-noctule-bats-are-sexually-dimorphic-in-migratory-behaviour-and-body-size-but-not-wing-shape
#19
M Teague O'Mara, Karla Bauer, Dominik Blank, Justin W Baldwin, Dina K N Dechmann
Within the large order of bats, sexual size dimorphism measured by forearm length and body mass is often female-biased. Several studies have explained this through the effects on load carrying during pregnancy, intrasexual competition, as well as the fecundity and thermoregulation advantages of increased female body size. We hypothesized that wing shape should differ along with size and be under variable selection pressure in a species where there are large differences in flight behaviour. We tested whether load carrying, sex differential migration, or reproductive advantages of large females affect size and wing shape dimorphism in the common noctule (Nyctalus noctula), in which females are typically larger than males and only females migrate long distances each year...
2016: PloS One
https://www.readbyqxmd.com/read/27876836/nf-kappa%C3%AE-inducing-kinase-regulates-stem-cell-phenotype-in-breast-cancer
#20
Karla Vazquez-Santillan, Jorge Melendez-Zajgla, Luis Enrique Jimenez-Hernandez, Javier Gaytan-Cervantes, Laura Muñoz-Galindo, Patricia Piña-Sanchez, Gustavo Martinez-Ruiz, Javier Torres, Patricia Garcia-Lopez, Carolina Gonzalez-Torres, Victor Ruiz, Federico Avila-Moreno, Marco Velasco-Velazquez, Mayra Perez-Tapia, Vilma Maldonado
Breast cancer stem cells (BCSCs) overexpress components of the Nuclear factor-kappa B (NF-κB) signaling cascade and consequently display high NF-κB activity levels. Breast cancer cell lines with high proportion of CSCs exhibit high NF-κB-inducing kinase (NIK) expression. The role of NIK in the phenotype of cancer stem cell regulation is poorly understood. Expression of NIK was analyzed by quantitative RT-PCR in BCSCs. NIK levels were manipulated through transfection of specific shRNAs or an expression vector...
November 23, 2016: Scientific Reports
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