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https://www.readbyqxmd.com/read/28817470/the-use-of-pharmacologic-cognitive-enhancers-in-competitive-chess
#1
Andreas G Franke, Pavel Dietz, Karla Ranft, Harald Balló, Perikles Simon, Klaus Lieb
No abstract text is available yet for this article.
August 16, 2017: Epidemiology
https://www.readbyqxmd.com/read/28815572/risk-of-second-primary-cancers-in-women-diagnosed-with-endometrial-cancer-in-german-and-swedish-cancer-registries
#2
Tianhui Chen, Hermann Brenner, Mahdi Fallah, Lina Jansen, Felipe A Castro, Karla Geiss, Bernd Holleczek, Alexander Katalinic, Sabine Luttmann, Kristina Sundquist, Meike Ressing, Leiting Xu, Kari Hemminki
Along with the increasing incidence and favorable prognosis, more women diagnosed with endometrial cancer may develop second primary cancers (SPCs). We aimed at investigating risk of SPCs after endometrial cancer in Germany and Sweden to provide insight into prevention strategies for SPCs. Endometrial cancer patients diagnosed at age ≥15 years in Germany during 1997-2011 and in Sweden nationwide during 1997-2012 were selected. Standardized incidence ratios (SIRs), calculated as the ratio of observed to expected numbers of cases, were used to assess the risk of a specific second cancer after endometrial cancer for both German and Swedish datasets...
August 17, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28815212/variable-virulence-of-biotype-3-vibrio-vulnificus-due-to-martx-toxin-effector-domain-composition
#3
Byoung Sik Kim, Hannah E Gavin, Karla J F Satchell
Vibrio vulnificus is an environmental organism that causes septic human infections characterized by high morbidity and mortality. The annual incidence and global distribution of this pathogen are increasing as ocean waters warm. Clinical strains exhibit variations in the primary virulence toxin, suggesting a potential for the emergence of new strains with altered virulence properties. A clonal outbreak of tilapia-associated wound infections in Israel serves as a natural experiment for the sudden emergence of a new V...
July 2017: MSphere
https://www.readbyqxmd.com/read/28812541/systematic-review-of-interventions-for-treating-or-preventing-antipsychotic-induced-tardive-dyskinesia
#4
Hanna Bergman, Dawn-Marie Walker, Adriani Nikolakopoulou, Karla Soares-Weiser, Clive E Adams
BACKGROUND: Antipsychotic medication can cause tardive dyskinesia (TD) - late-onset, involuntary, repetitive movements, often involving the face and tongue. TD occurs in > 20% of adults taking antipsychotic medication (first-generation antipsychotics for > 3 months), with this proportion increasing by 5% per year among those who continue to use these drugs. The incidence of TD among those taking newer antipsychotics is not different from the rate in people who have used older-generation drugs in moderate doses...
August 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28810895/understanding-the-cluster-randomised-crossover-design-a-graphical-illustraton-of-the-components-of-variation-and%C3%A2-a-sample-size%C3%A2-tutorial
#5
Sarah J Arnup, Joanne E McKenzie, Karla Hemming, David Pilcher, Andrew B Forbes
BACKGROUND: In a cluster randomised crossover (CRXO) design, a sequence of interventions is assigned to a group, or 'cluster' of individuals. Each cluster receives each intervention in a separate period of time, forming 'cluster-periods'. Sample size calculations for CRXO trials need to account for both the cluster randomisation and crossover aspects of the design. Formulae are available for the two-period, two-intervention, cross-sectional CRXO design, however implementation of these formulae is known to be suboptimal...
August 15, 2017: Trials
https://www.readbyqxmd.com/read/28809155/microbe-profile-candida-albicans-a-shape-changing-opportunistic-pathogenic-fungus-of-humans
#6
Neil A R Gow, Bhawna Yadav
(a) Morphotypes of Candida albicans (blue sector, vegetative forms; pink sector, forms related to mating or changes in ploidy). Cell types shown include: budding yeast cells; elongated conjoined yeasts forming pseudohyphae; parallel-sided hyphae; chlamydospores formed from suspensor cells; enlarged goliath cells formed under zinc deprivation (unpublished study, image from Duncan Wilson); intestinal gut form cells (image from Suzanne Noble); mating competence defined by white-grey-opaque cell transitions (images from Guanghua Huang); elongated chemotactic shmoo-mating projections leading to tetraploid zygote formation (images from David Soll and Karla Daniels); trimera formed by unequal chromosome segregation under antifungal exposure (image from Judith Berman)...
August 15, 2017: Microbiology
https://www.readbyqxmd.com/read/28802239/synergistic-antinociceptive-interaction-of-syzygium-aromaticum-or-rosmarinus-officinalis-coadministered-with-ketorolac-in-rats
#7
Karla Lyzet Beltrán-Villalobos, Myrna Déciga-Campos, Hidemi Aguilar-Mariscal, María Eva González-Trujano, María Fernanda Martínez-Salazar, María de Los Ángeles Ramírez-Cisneros, María Yolanda Rios, Francisco Javier López-Muñoz
Syzygium aromaticum (L.) Merr. & L.M. Perry (Mirtaceae) and Rosmarinus officinalis L. (Lamiaceae) are both medicinal plants used for centuries to alleviate pain. The aim of the study was to demonstrate the therapeutic potential utility of herb-drug association of S. aromaticum essential oil or R. officinalis ethanolic extract coadministered with ketorolac. Antinociceptive pharmacological interaction was investigated by an isbolographic study using the formalin test in rats. Both alone and in combination with ketorolac; S...
August 9, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28796692/reticulated-purpura-in-the-abdomen-of-a-severely-ill-patient
#8
Caio Formiga, Karla Pacheco, Thiago Jeunon
No abstract text is available yet for this article.
August 3, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28793197/glycosylation-with-o-linked-%C3%AE-n-acetylglucosamine-o-glcnac-induces-vascular-dysfunction-via-production-of-superoxide-anion-reactive-oxygen-species
#9
Leonardo Souza-Silva, Rhéure Alves-Lopes, Jéssica Silva Miguez, Vanessa Dela Justina, Karla Bianca Neves, Fabíola Leslie Mestriner, Rita C Tostes, Fernanda Regina Giachini, Victor V Lima
Overproduction of superoxide anion (•O2-) and O-linked β-N-acetylglucosamine (O-GlcNAc)-modification in the vascular system are contributors to endothelial dysfunction. This study tested the hypothesis that increased levels of O-GlcNAc-modified proteins contribute to •O2- production via activation of NADPH oxidase, resulting in impaired vasodilation. Rat aortic segments and vascular smooth muscle cell (VSMCs) were incubated with vehicle (methanol) or PUGNAc (100 µM). PUGNAc produced a time-dependent increase in O-GlcNAc levels in VSMC and decreased endothelium-dependent relaxation, which was prevented by apocynin and Tiron, suggesting that •O2- contributes to endothelial dysfunction under augmented O-GlcNAc levels...
August 9, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28793045/home-blood-pressure-monitoring-as-an-alternative-to-confirm-diagnoses-of-hypertension-in-adolescents-with-elevated-office-blood-pressure-from-a-brazilian-state-capital
#10
Thaís Inacio Rolim Póvoa, Thiago Veiga Jardim, Carolina de Souza Carneiro, Vanessa Roriz Ferreira, Karla Lorena Mendonça, Polyana Resende Silva de Morais, Flávia Miquetichuc Nogueira Nascente, Weimar Kunz Sebba Barroso de Souza, Ana Luiza Lima Sousa, Paulo César Brandão Veiga Jardim
Background: Regional differences of using home blood pressure monitoring (HBPM) as an alternative to ambulatory blood pressure monitoring (ABPM) in hypertensive adolescents are unknown. Objectives: Define if HBPM is an option to confirm diagnoses of hypertension in adolescents from a Brazilian capital with elevated office blood pressure (BP). Methods: Adolescents (12-18years) from public and private schools with BP > 90th percentile were studied to compare and evaluate the agreement among office BP measurements, HBPM and ambulatory BP monitoring...
August 7, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28792005/splicing-and-transcription-touch-base-co-transcriptional-spliceosome-assembly-and-function
#11
REVIEW
Lydia Herzel, Diana S M Ottoz, Tara Alpert, Karla M Neugebauer
Several macromolecular machines collaborate to produce eukaryotic messenger RNA. RNA polymerase II (Pol II) translocates along genes that are up to millions of base pairs in length and generates a flexible RNA copy of the DNA template. This nascent RNA harbours introns that are removed by the spliceosome, which is a megadalton ribonucleoprotein complex that positions the distant ends of the intron into its catalytic centre. Emerging evidence that the catalytic spliceosome is physically close to Pol II in vivo implies that transcription and splicing occur on similar timescales and that the transcription and splicing machineries may be spatially constrained...
August 9, 2017: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/28791495/joint-relative-risks-for-estrogen-receptor-positive-breast-cancer-from-a-clinical-model-polygenic-risk-score-and-sex-hormones
#12
Yiwey Shieh, Donglei Hu, Lin Ma, Scott Huntsman, Charlotte C Gard, Jessica W T Leung, Jeffrey A Tice, Elad Ziv, Karla Kerlikowske, Steven R Cummings
BACKGROUND: Models that predict the risk of estrogen receptor (ER)-positive breast cancers may improve our ability to target chemoprevention. We investigated the contributions of sex hormones to the discrimination of the Breast Cancer Surveillance Consortium (BCSC) risk model and a polygenic risk score comprised of 83 single nucleotide polymorphisms. METHODS: We conducted a nested case-control study of 110 women with ER-positive breast cancers and 214 matched controls within a mammography screening cohort...
August 8, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28791126/investigation-of-sphingosine-kinase-1-in-interferon-responses-during-dengue-virus-infection
#13
Amanda L Aloia, Julie K Calvert, Jennifer N Clarke, Lorena T Davies, Karla J Helbig, Stuart M Pitson, Jillian M Carr
Dengue virus (DENV) regulates sphingosine kinase (SK)-1 activity and chemical inhibition of SK1 reduces DENV infection. In primary murine embryonic fibroblasts (pMEFs) lacking SK1 however, DENV infection is enhanced and this is associated with induction of normal levels of interferon beta (IFN-β) but reduced levels of IFN-stimulated genes (ISGs). We have further investigated this link between SK1 and type I IFN responses. DENV infection downregulates cell-surface IFN-alpha receptor (IFNAR)1 in both wild-type (WT) and SK1(-)(/-) pMEF, but, consistent with poor ISG responses, shows reduced induction of phosphorylated (p)-STAT1 and key IFN regulatory factors (IRF)1 and -7 in SK1(-/-) pMEF...
July 2017: Clinical & Translational Immunology
https://www.readbyqxmd.com/read/28791079/association-between-tooth-agenesis-and-skeletal-malocclusions
#14
Ana Maria Guerra Costa, Mariana Trevizan, Mírian Aiko Nakane Matsumoto, Raquel Assed Bezerra da Silva, Lea Assed Bezerra da Silva, Karla Carpio Horta, Fabio Lourenço Romano, Paulo Nelson-Filho, Erika Calvano Küchler
OBJECTIVES: The aim of this study was to evaluate the association between tooth agenesis and skeletal malocclusions in Brazilian non-syndromic orthodontic patients. MATERIAL AND METHODS: Pretreatment orthodontic records of 348 patients of both genders and with various skeletal malocclusions were examined. Tooth agenesis was evaluated in panoramic radiographs. Angular measurements were taken from lateral cephalometric radiographs to classify the patient's malocclusion as skeletal Class I, Class II and Class III...
April 2017: Journal of Oral & Maxillofacial Research
https://www.readbyqxmd.com/read/28783670/low-cd21-expression-defines-a-population-of-recent-germinal-center-graduates-primed-for-plasma-cell-differentiation
#15
Denise Lau, Linda Yu-Ling Lan, Sarah F Andrews, Carole Henry, Karla Thatcher Rojas, Karlynn E Neu, Min Huang, Yunping Huang, Brandon DeKosky, Anna-Karin E Palm, Gregory C Ippolito, George Georgiou, Patrick C Wilson
In this study, we report that antigen-specific CD19(+)CD27(+)CD21(lo) (CD21(lo)) B cells are transiently induced 14 to 28 days after immunization, at the time germinal centers (GCs) peak. Although clonally related to memory B cells and plasmablasts, CD21(lo) cells form distinct clades within phylogenetic trees based on accumulated variable gene mutations, supporting exit from active GCs. CD21(lo) cells express a transcriptional program, suggesting that they are primed for plasma cell differentiation and are refractory to GC differentiation, although they do not spontaneously secrete antibody...
January 27, 2017: Science Immunology
https://www.readbyqxmd.com/read/28782718/merging-in-silico-and-in-vitro-salivary-protein-complex-partners-using-the-string-database-a-tutorial
#16
Karla Tonelli Bicalho Crosara, Eduardo Buozi Moffa, Yizhi Xiao, Walter Luiz Siqueira
Protein-protein interaction is a common physiological mechanism for protection and actions of proteins in an organism. The identification and characterization of protein-protein interactions in different organisms is necessary to better understand their physiology and to determine their efficacy. In a previous in vitro study using mass spectrometry, we identified 43 proteins that interact with histatin 1. Six previously documented interactors were confirmed and 37 novel partners were identified. In this tutorial, we aimed to demonstrate the usefulness of the STRING database for studying protein-protein interactions...
August 3, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28782388/nanotechnology-based-drug-delivery-of-ropinirole-for-parkinson-s-disease
#17
Emilia Barcia, Liudmila Boeva, Luis García-García, Karla Slowing, Ana Fernández-Carballido, Yaquelyn Casanova, Sofía Negro
A new drug delivery system is developed for ropinirole (RP) for the treatment of Parkinson's disease (PD) consisting of biodegradable poly (D,L-lactide-co-glycolide) (PLGA) nanoparticles (NPs). The formulation selected was prepared with 8 mg RP and 50 mg PLGA 502. This formulation exhibited mean encapsulation efficiency of 74.8 ± 8.2%, mean particle size lower than 155 nm, the zeta potential of -14.25 ± 0.43 mV and zero-order in vitro release of RP (14.13 ± 0.17 μg/h/10 mg NPs) for 5 d...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28777691/behavioral-effect-of-sterculia-apetala-seed-oil-consumption-in-male-zucker-rats
#18
Socorro Herrera-Meza, Juan Francisco Rodríguez-Landa, Armando J Martínez, Grecia Herrera-Meza, Rafael Fernández-Demeneghi, Karla Reyes-Saldaña, Rosa María Oliart-Ros
Sterculia apetala (order: Malvales, family: Sterculiaceae) seed oil contains two cyclopropene fatty acids: sterculic and malvalic acid. Both positive and negative effects have been associated with the consumption of sterculic oil. In Mexico, S. apetala seeds are consumed after being boiled or roasted, used as chocolate flavoring, and utilized as animal fodder. Therefore, it is important to evaluate whether the consumption of this seed has a negative impact on the organism. The aim of this study was to evaluate the effect of administration of sterculic oil, during an 8-week period, on anxiety-like behavior and spontaneous locomotor activity in Zucker rats, analyzed through light/dark and open-field tests...
August 4, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28772696/effect-of-immobilized-antithrombin-iii-on-the-thromboresistance-of-polycarbonate-urethane
#19
Karin Lukas, Karin Stadtherr, Andre Gessner, Daniel Wehner, Thomas Schmid, Hans Peter Wendel, Christof Schmid, Karla Lehle
The surface of foils and vascular grafts made from a thermoplastic polycarbonate urethanes (PCU) (Chronoflex AR) were chemically modified using gas plasma treatment, binding of hydrogels-(1) polyethylene glycol bisdiamine and carboxymethyl dextran (PEG-DEX) and (2) polyethyleneimine (PEI)-and immobilization of human antithrombin III (AT). Their biological impact was tested in vitro under static and dynamic conditions. Static test methods showed a significantly reduced adhesion of endothelial cells, platelets, and bacteria, compared to untreated PCU...
March 24, 2017: Materials
https://www.readbyqxmd.com/read/28771225/the-ovarian-reserve-is-depleted-during-puberty-in-a-hormonally-driven-process-dependent-on-the-pro-apoptotic-protein-bmf
#20
Seng H Liew, Quynh-Nhu Nguyen, Andreas Strasser, Jock K Findlay, Karla J Hutt
In females, germ cells are maintained in ovarian structures called primordial follicles. The number of primordial follicles in the ovarian reserve is a critical determinant of the length of the fertile lifespan. Despite this significance, knowledge of the precise physiological mechanisms that regulate primordial follicle number is lacking. In this study we show that a wave of primordial follicle depletion occurs during the transition to adulthood in mice. We demonstrate that this sudden and dramatic loss of primordial follicles is hormonally triggered and identify the pro-apoptotic BH3-only protein, BCL-2 modifying factor (BMF), as essential for this process, implicating the intrinsic apoptotic pathway as a key mechanism...
August 3, 2017: Cell Death & Disease
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