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JOURNAL ARTICLE
Nagarjunachary Ragi, Scott J Walmsley, Foster C Jacobs, Thomas A Rosenquist, Viktoriya S Sidorenko, Lihua Yao, Laura A Maertens, Christopher J Weight, Silvia Balbo, Peter W Villalta, Robert J Turesky
Air pollution, tobacco smoke, and red meat are associated with renal cell cancer (RCC) risk in the United States and Western Europe; however, the chemicals that form DNA adducts and initiate RCC are mainly unknown. Aristolochia herbaceous plants are used for medicinal purposes in Asia and worldwide. They are a significant risk factor for upper tract urothelial carcinoma (UTUC) and RCC to a lesser extent. The aristolochic acid (AA) 8-methoxy-6-nitrophenanthro-[3,4- d ]-1,3-dioxolo-5-carboxylic acid (AA-I), a component of Aristolochia herbs, contributes to UTUC in Asian cohorts and in Croatia, where AA-I exposure occurs from ingesting contaminated wheat flour...
January 9, 2024: Chemical Research in Toxicology
#22
JOURNAL ARTICLE
Apurwa Prasad, Dhiran Verghese, Sumathi Vijaya Rangan, Nivedita Sunadarajan
We present a case of a man in his 70s who presented with worsening rectal and back pain associated with weight loss, dyspnoea and brownish discolouration of urine. Physical examination noted abdominal distention and epigastric tenderness. Laboratory investigations revealed acute kidney injury, hyperkalaemia, hyperphosphataemia and hyperuricaemia. Contrast CT of the abdomen/pelvis showed multiple, low-density masses throughout the liver, suspicious for metastatic disease. Oesophagogastroduodenoscopy demonstrated a large, fungating, infiltrative and ulcerated mass in the gastric body and lesser curvature of the stomach...
January 8, 2024: BMJ Case Reports
#23
JOURNAL ARTICLE
Peir-In Liang, Yu-Ching Wei, Huan-Da Chen, Yu-Chun Ma, Hung-Lung Ke, Chu-Chun Chien, Hao-Wen Chuang
Urothelial carcinoma (UC) is common cancer worldwide with a high prevalence in Taiwan, especially in the upper urinary tract, including the renal pelvis and ureter, also classifying as upper urinary tract urothelial carcinoma. Here, we aim to find a representative prognostic marker that strongly correlates to this type of carcinoma. Transforming growth factor beta-1-induced transcript 1 (TGFB1I1) is a cofactor of cellular TGF-β1 and interacts with various nuclear receptors. The previous study showed that TGFB1I1 promotes focal adhesion formation, contributing to the epithelial-mesenchymal transition (EMT) with actin cytoskeleton and vimentin through TGFB1I1 regulation...
January 5, 2024: Kaohsiung Journal of Medical Sciences
#24
JOURNAL ARTICLE
Tsung Yu Yu, Hung Jen Wang, Min Tse Sung, Yao Chi Chuang, Yen Ta Chen, Yuan Tso Cheng, Chih Hsiung Kang, Hui Ying Liu, Yin Lun Chang, Hao Lun Luo
PURPOSE: To investigate the prognostic impact of variant histology (VH) on oncological outcomes in patients with upper urinary tract urothelial carcinoma (UTUC) who had undergone radical nephroureterectomy (RNU). PATIENTS AND METHODS: A total of 1239 patients with clinically localized UTUC who underwent RNU at a single institution between January 2005 and June 2020 were included. The VH was reviewed by a uro-pathologist at our institution. The Cox regression model was used to perform multivariate analysis, including VH and other established prognostic factors for post-RNU oncological outcomes (intravesical recurrence [IVR], non-urothelial recurrence, and cancer-specific death)...
January 2, 2024: International Journal of Urology: Official Journal of the Japanese Urological Association
#25
JOURNAL ARTICLE
Junaid Raja, Richard Pigg, Yufeng Li, Cody Savage, Theresa M Caridi, Junjian Huang, Andrew J Gunn
PURPOSE: To assess the safety, technical success, and clinical outcomes of percutaneous cryoablation (PCA) in patients with anterior renal tumors. METHODS: A retrospective analysis of patients with anterior renal tumors, defined as tumors at or anterior to the level of the renal pelvis, treated with CT-guided PCA from 2008 to 2022. Summary statistics included demographics and baseline tumor attributes. Treatment and follow-up metrics included primary and secondary technical success, adverse events (AEs) according to the SIR classification, local recurrence, overall survival (OS), and cancer-specific survival (CSS))...
December 27, 2023: Abdominal Radiology
#26
JOURNAL ARTICLE
Thi-Van-Trinh Tran, Sara J Schonfeld, Elisa Pasqual, Megan R Haymart, Lindsay M Morton, Cari M Kitahara
Background: Despite the excellent disease-specific survival associated with low-risk differentiated thyroid cancer (DTC), its diagnosis and management have been linked to patient concerns about cancer recurrence, treatment-related health risks, and mortality. Lack of information regarding long-term health outcomes can perpetuate these concerns. Therefore, we assessed all-cause and cause-specific mortality in a large cohort of individuals diagnosed with low-risk DTC. Methods: From the U.S. Surveillance, Epidemiology, and End Results-12 cancer registry database (1992-2019), we identified 51,854 individuals (81...
January 22, 2024: Thyroid: Official Journal of the American Thyroid Association
#27
Aoife McVey, David Chen, Hayden Snow, Philip Chan, Raghava Kashyap, Brian Kelly
No abstract text is available yet for this article.
December 26, 2023: BJU International
#28
JOURNAL ARTICLE
Yuzhong Ye, Yongqiang Zheng, Junteng Li, Qi Miao, Mei Lin, Jiawei Chen, Hailong Ruan, Xiaoping Zhang
BACKGROUND: As an important kidney-sparing treatment for upper urothelial carcinoma (UTUC), whether endoscopic excision can be performed without sacrificing oncologic outcomes remains indefinite. This study aimed to investigate the prevalence and efficacy of endoscopic excision, in patients with non-muscle invasive UTUC (NMIUTUC) and compare them to those of radical nephroureterectomy (RNU). METHODS: Using the Surveillance, Epidemiology, and End Results database, we reviewed 4347 cases with NMIUTUC (cTis/Ta/T1-N0-M0,≤ 5...
December 2023: Heliyon
#29
JOURNAL ARTICLE
Jian Zhao, Xiaohui Ding, Cheng Peng, Xia Tian, Meifeng Wang, Yonggui Fu, Huiping Guo, Xu Bai, Xue Zhai, Qingbo Huang, Kan Liu, Lin Li, Huiyi Ye, Xu Zhang, Xin Ma, Haiyi Wang
PURPOSE: To determine the optimal cut-off value of Ki-67 for predicting the survival of patients with clear cell renal cell carcinoma (ccRCC) and tumor thrombus and to explore the correlation between Ki-67 expression and pathological features. PATIENTS AND METHODS: We retrospectively analyzed Ki-67 immunohistochemical staining of ccRCC and tumor thrombus resected from February 2006 to February 2022. The survival rate was evaluated using the Kaplan-Meier method. The optimal cut-off value of the Ki-67 expression for predicting survival was determined by the minimum P-value method...
November 28, 2023: Urologic Oncology
#30
JOURNAL ARTICLE
Johannes Bobjer, Axel Gerdtsson, Johan Abrahamsson, Gediminas Baseckas, Mats Bergkvist, Mats Bläckberg, Johan Brändstedt, Georg Jancke, Oskar Hagberg, Petter Kollberg, Karl-Johan Lundström, Annica Löfgren, Martin Nyberg, Liselotte Rian Mårtensson, Ymir Saemundsson, Elin Ståhl, Anne Sörenby, Åsa Warnolf, Fredrik Liedberg
BACKGROUND: There is limited information on the distribution of retroperitoneal lymph node metastases (LNMs) in upper tract urothelial carcinoma (UTUC). OBJECTIVE: To investigate the location of LNMs in UTUC of the renal pelvis or proximal ureter and short-term complications after radical nephroureterectomy (RNU) with lymph node dissection (LND). DESIGN SETTING AND PARTICIPANTS: This was a prospective Nordic multicenter study (four university hospitals, two county hospitals)...
November 2023: European urology open science
#31
JOURNAL ARTICLE
Xiaofeng Tang, Xiangpeng Zhan, Xiaomin Chen
The goal of this study is exploring the disparity of incidence, mortality and survival outcome among transitional cell carcinomas (TCCs) in the 4 parts of urinary system. This study comprehensively evaluates these disparities using the Surveillance, Epidemiology, and End Results (SEER) (2000-2018) database. According to the SEER database, the urinary tract is divided into 4 parts: urinary bladder, renal pelvis, ureter, and urethra. The joinpoint regression was used to analyze the secular trend of incidence and incidence-based mortality (IBM)...
November 17, 2023: Medicine (Baltimore)
#32
REVIEW
Mohamed J Saadh, Hayaa M Alhuthali, Oblitas Gonzales Aníbal, José Ander Asenjo-Alarcón, Dhuha Ghassan Younus, Ahmed Alhili, Zainab Hussein Adhab, Ohud Alsalmi, Amal F Gharib, Renzon Daniel Cosme Pecho, Reza Akhavan-Sigari
Mesenchymal stem cells (MSCs) are recognized for their remarkable ability to differentiate into multiple cell types. They are also known to possess properties that can fight cancer, leading to attempts to modify MSCs for use in anticancer treatments. However, MSCs have also been found to participate in pathways that promote tumor growth. Many studies have been conducted to explore the potential of MSCs for clinical applications, but the results have been inconclusive, possibly due to the diverse nature of MSC populations...
November 10, 2023: Cell Biology International
#33
Nao Iwamoto, Masaaki Oikawa, Takashi Kukimoto, Jun Ito, Kazuhiro Murakami, Yasuhiro Kaiho
INTRODUCTION: Gastric outlet obstruction caused by upper tract urothelial carcinoma is rare. CASE PRESENTATION: A 78-year-old man presented to the hospital with nausea and vomiting. No hematuria was observed. Computed tomography revealed a tumor in the right renal pelvis and duodenal stenosis. Gastrojejunostomy was performed to treat the symptoms of the gastric outlet obstruction so that the patient could resume oral intake and outpatient chemotherapy. Chemotherapy was unsuccessful, and the patient died 9 months after the gastrojejunostomy...
November 2023: IJU case reports
#34
JOURNAL ARTICLE
Peipei Shang, Cheng Lou, Lei Yin, Chenjie Tao, Yulong Dong, Guang Yang, Zhengang Yuan
The prognosis of renal pelvis cancer is poor and therapeutic options are limited, especially for patients with advanced disease. In this report, we present a case of advanced renal pelvis carcinoma in a male patient in his 60s, characterized by an activating mutation in ERBB2 . Clinical evaluation resulted in a pathological diagnosis of renal pelvis carcinoma with liver metastasis. Immunohistochemistry staining results suggested that CK, P63, and PAX8 were positively expressed, while Sy, CK7, CK20, S100, PAX8, and HEP1 were negatively expressed...
November 2023: Journal of International Medical Research
#35
JOURNAL ARTICLE
Hyung Kyu Park
Metastasis is the leading cause of death in patients with bladder cancer. This study utilized a statistical analysis of patient data from the Surveillance, Epidemiology, and End Results database to examine the influence of histological type and primary site on the metastatic behavior of bladder cancer. Significantly different metastatic patterns were observed among bladder cancer patients depending on their histological type. Patients with squamous cell carcinoma showed a significantly ( p < 0.001) lower bone metastasis rate (27...
October 11, 2023: Current Oncology
#36
Ayesha Khan, Md Abu Sayed, Khaled Hosny, Godwins Echejoh, Santhi Kumar
Tumour-to-tumour metastases (TTM) are a rare phenomenon in which a primary tumour has metastasised within another distant primary tumour. We present the case of a 63-year-old female who presented with right-sided breast cancer. An incidental left-sided renal mass was detected on staging CT of the thorax, abdomen, and pelvis (CT-TAP). The patient had no evidence of metastases below the diaphragm. Histology following a radical left nephrectomy revealed metastatic breast cancer within a renal cell carcinoma (RCC)...
September 2023: Curēus
#37
JOURNAL ARTICLE
Hadrien Charvat, Kayo Nakata
No abstract text is available yet for this article.
October 19, 2023: Japanese Journal of Clinical Oncology
#38
RANDOMIZED CONTROLLED TRIAL
Raphael Koch, Lianne Haveman, Ruth Ladenstein, Benedicte Brichard, Heribert Jürgens, Sona Cyprova, Henk van den Berg, Wolf Hassenpflug, Anna Raciborska, Torben Ek, Daniel Baumhoer, Gerlinde Egerer, Leo Kager, Marleen Renard, Peter Hauser, Stefan Burdach, Judith V M G Bovee, Angela M Hong, Peter Reichardt, Jarmila Kruseova, Arne Streitbürger, Thomas Kühne, Torsten Kessler, Marie Bernkopf, Trude Butterfaß-Bahloul, Catharina Dhooge, Sebastian Bauer, János Kiss, Michael Paulussen, Fiona Bonar, Andreas Ranft, Beate Timmermann, Jelena Rascon, Volker Vieth, Jukka Kanerva, Andreas Faldum, Wolfgang Hartmann, Lars Hjorth, Vivek A Bhadri, Markus Metzler, Hans Gelderblom, Uta Dirksen
PURPOSE: The phase III, open-label, prospective, multicenter, randomized Ewing 2008R1 trial (EudraCT2008-003658-13) was conducted in 12 countries to evaluate the effect of zoledronic acid (ZOL) maintenance therapy compared with no add-on regarding event-free survival (EFS, primary endpoint) and overall survival (OS) in standard-risk Ewing sarcoma (EWS). PATIENTS AND METHODS: Eligible patients had localized EWS with either good histologic response to induction chemotherapy and/or small tumors (<200 mL)...
December 15, 2023: Clinical Cancer Research
#39
Omar Bellouki, Ahmed Ibrahimi, Ilyas Soufiani, Imad Boualaoui, Hachem El Sayegh, Yassine Nouini
INTRODUCTION: Renal cell carcinoma (RCC) is a relatively rare malignancy often discovered incidentally. Approximately 15 % of cases are metastatic at diagnosis, commonly affecting the lungs, bones, lymph nodes, and liver. We present an exceptional case of RCC metastasizing to the eyelid. CASE PRESENTATION: A 67-year-old female with no prior cancer history exhibited rapidly progressing left blepharoptosis. Examination revealed a painless, solid eyelid mass. Immunohistochemistry of the eyelid mass biopsy identified a carcinoma potentially of renal origin...
November 2023: International Journal of Surgery Case Reports
#40
JOURNAL ARTICLE
Rayan Nikkilä, Miikka Peltomaa, Timo Carpén, Jan Ivar Martinsen, Sanna Heikkinen, Jenny Selander, Ingrid Sivesind Mehlum, Jóhanna Eyrún Torfadottir, Antti Mäkitie, Eero Pukkala
INTRODUCTION: Professional visual artists constitute a heterogeneous vocational group, including, but not limited to painters, photographers, textile artists, and sculptors who may face exposure to workplace hazardous substances and lifestyle factors that may contribute to the development of selected cancers. The objective of this registry-based cohort study was to assess the cancer incidence among Nordic visual artists. MATERIALS AND METHODS: This study is based on data from the Nordic Occupational Cancer (NOCCA) project that combines census data of 15 million people from all Nordic countries and cancer registries from 1961 to 2005...
October 5, 2023: Acta Oncologica
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