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https://www.readbyqxmd.com/read/27900539/seom-clinical-guideline-for-treatment-of-muscle-invasive-and-metastatic-urothelial-bladder-cancer-2016
#1
M Lázaro, E Gallardo, M Doménech, Á Pinto, A González Del Alba, J Puente, O Fernández, A Font, N Lainez, S Vázquez
The goal of this article is to provide recommendations for the diagnosis and treatment of muscle-invasive and metastatic bladder cancer. The diagnosis of muscle-invasive bladder cancer is made by pathologic evaluation after transurethral resection. Recently, a molecular classification has been proposed. Staging of muscle-invasive bladder cancer must be done by computed tomography scans of the chest, abdomen and pelvis and classified on the basis of UICC system. Radical cystectomy and lymph node dissection are the treatment of choice...
November 29, 2016: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/27832048/vital-signs-disparities-in-tobacco-related-cancer-incidence-and-mortality-united-states-2004-2013
#2
S Jane Henley, Cheryll C Thomas, Saida R Sharapova, Behnoosh Momin, Greta M Massetti, Deborah M Winn, Brian S Armour, Lisa C Richardson
BACKGROUND: Tobacco use causes at least 12 types of cancer and is the leading preventable cause of cancer. METHODS: Data from the United States Cancer Statistics dataset for 2004-2013 were used to assess incidence and death rates and trends for cancers that can be caused by tobacco use (tobacco-related cancers: oral cavity and pharynx; esophagus; stomach; colon and rectum; liver; pancreas; larynx; lung, bronchus, and trachea; kidney and renal pelvis; urinary bladder; cervix; and acute myeloid leukemia) by sex, age, race, ethnicity, state, county-level poverty and educational attainment, and cancer site...
November 11, 2016: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/27819754/urological-cancer-related-to-familial-syndromes
#3
Walter Henriques da Costa, George Jabboure, Isabela Werneck da Cunha
Cancer related to hereditary syndromes corresponds to approximately 5-10% of all tumors. Among those from the genitourinary system, many tumors had been identified to be related to genetic syndromes in the last years with the advent of new molecular genetic tests. New entities were described or better characterized, especially in kidney cancer such as hereditary leiomyomatosis renal cell carcinoma (HLRCC), succinate de¬hydrogenase kidney cancer (SDH-RCC), and more recently BAP1 germline mutation re¬lated RCC...
November 2, 2016: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/27790508/role-of-urinary-and-serum-carbohydrate-antigen-19-9-as-a-biomarker-in-diagnosis-of-adult-giant-hydronephrosis
#4
Indraneel Banerjee, Vinay Tomar, Sher Singh Yadav, Nachiket Vyas, Suresh Yadav, Brijesh Sathian
INTRODUCTION: The most common cause of adult Giant Hydronephrosis (GH) is congenital Uretero-Pelvic Junction (UPJ) obstruction. Conventional imaging modalities, like Intravenous Urography (IVU) and Computed Tomography Urography (CTU) and radionuclide renal scan can be fallacious. Serum carbohydrate antigen 19-9 (CA19-9) is a useful tumour marker for gastrointestinal and pancreatic cancer. Only a few studies and case reports have shown raised serum levels due to benign hydronephrosis and GH...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27785421/lynch-syndrome-and-exposure-to-aristolochic-acid-in-upper-tract-urothelial-carcinoma-its-clinical-impact
#5
REVIEW
Pierre Colin, Thomas Seisen, Romain Mathieu, Sharohkh F Shariat, Morgan Rouprêt
The purpose of the current review was to describe the clinical risk for Lynch syndrome (LS) after exposure to aristolochic acid (AA) in cases of upper urinary-tract urothelial carcinoma (UTUC). A systematic review of the scientific literature was performed using the Medline database (National Library of Medicine, PubMed) using the following keywords: epidemiology, risk factor, AA, Balkan nephropathy (BNe), LS, hereditary cancer, hereditary non-polyposis colorectal cancer (HNPCC), mismatch repair genes, urothelial carcinomas, upper urinary tract, renal pelvis, ureter, Amsterdam criteria, genetic counselling, mismatch repair genes, genetic instability, microsatellite, and Bethesda guidelines...
October 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/27775761/state-level-cancer-mortality-attributable-to-cigarette-smoking-in-the-united-states
#6
Joannie Lortet-Tieulent, Ann Goding Sauer, Rebecca L Siegel, Kimberly D Miller, Farhad Islami, Stacey A Fedewa, Eric J Jacobs, Ahmedin Jemal
Importance: State-specific information about the health burden of smoking is valuable because state-level initiatives are at the forefront of tobacco control. Smoking-attributable cancer mortality estimates are currently available nationally and by cancer, but not by state. Objective: To calculate the proportion of cancer deaths among adults 35 years and older that were attributable to cigarette smoking in 2014 in each state and the District of Columbia. Design, Setting, and Participants: The population-attributable fraction (PAF) of cancer deaths due to cigarette smoking was computed using relative risks for 12 smoking-related cancers (acute myeloid leukemia and cancers of the oral cavity and pharynx; esophagus; stomach; colorectum; liver; pancreas; larynx; trachea, lung, and bronchus; cervix uteri; kidney and renal pelvis; and urinary bladder) from large US prospective studies and state-specific smoking prevalence data from the Behavioral Risk Factor Surveillance System...
October 24, 2016: JAMA Internal Medicine
https://www.readbyqxmd.com/read/27720534/systematic-review-on-the-fate-of-the-remnant-urothelium-after-radical-cystectomy
#7
Georgios Gakis, Peter C Black, Bernard H Bochner, Stephen A Boorjian, Arnulf Stenzl, George N Thalmann, Wassim Kassouf
CONTEXT: Urothelial carcinoma is considered a pan-urothelial disease. As such, the remnant urothelium in the upper urinary tract and urethra following radical cystectomy (RC) remains at risk for secondary urothelial tumors (SUTs). OBJECTIVE: To describe the incidence, diagnosis, treatment, and outcomes of patients with SUTs after RC. EVIDENCE ACQUISITION: A systematic search was conducted using PubMed database according to Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines to identify studies between 1970 and 2016 reporting on malignant diseases of the urothelium after RC for bladder cancer...
October 6, 2016: European Urology
https://www.readbyqxmd.com/read/27694174/evaluation-of-prostate-cancer-with-radiolabeled-amino-acid-analogs
#8
David M Schuster, Cristina Nanni, Stefano Fanti
Conventional imaging of prostate cancer has limitations related to the frequently indolent biology of the disease. PET is a functional imaging method that can exploit various aspects of tumor biology to enable greater detection of prostate cancer than can be provided by morphologic imaging alone. Radiotracers that are in use or under investigation for targeting salient features of prostate cancer include those directed to glucose, choline, acetate, prostate-specific membrane antigen, bombesin, and amino acids...
October 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27658388/current-trends-in-the-incidence-and-survival-rate-of-urological-cancers-in-korea
#9
Jae Young Joung, Jiwon Lim, Chang-Mo Oh, Kyu-Won Jung, Hyunsoon Cho, Sung Han Kim, Ho Kyung Seo, Weon Seo Park, Jinsoo Chung, Kang Hyun Lee, Young-Joo Won
Purpose: This descriptive study assessed the current trends in the incidence of urological cancers and patient survival in Korea. Materials and Methods: In this nationwide retrospective observational study based on the data from the Korea National Cancer Incidence Database (KNCIDB), this study analyzed the age-standardized incidence rates (ASRs) and annual percentage changes (APCs) of kidney, bladder, prostate, testicular, and penile cancers as well as cancer of the renal pelvis and ureter between 1999 and 2012...
September 23, 2016: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/27634566/dynamic-contrast-enhanced-magnetic-resonance-imaging-as-a-pharmacodynamic-biomarker-for-pazopanib-in-metastatic-renal-carcinoma
#10
Randy F Sweis, Milica Medved, Shannon Towey, Gregory S Karczmar, Aytekin Oto, Russell Z Szmulewitz, Peter H O'Donnell, Paul Fishkin, Theodore Karrison, Walter M Stadler
INTRODUCTION/BACKGROUND: Traditional imaging assessment criteria might not correlate well with clinical benefit from vascular endothelial growth factor pathway-directed therapy in metastatic renal cancer. Preclinical data suggest tumor growth is preceded by a rise in K(trans) level, a parameter derived from dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) that reflects vascular permeability. We thus hypothesized that K(trans) might be a predictive biomarker for pazopanib...
August 17, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/27457483/ct2-bladder-cancer
#11
REVIEW
Mark S Soloway
The patient is an 80-year-old man who presented with gross hematuria. His past medical history indicates he was a cigarette smoker with 50 pack/years. He was successfully treated for carcinoma of the lung 7 years ago. He received chemotherapy, radiation, and surgery. He has mild COPD but has a good performance status. His laboratory studies do not indicate any abnormalities in terms of renal function. He does not have any significant cardiac disease. He has a medium build. He had prostate cancer and underwent a successful radical prostatectomy 10 years ago...
September 2016: Current Urology Reports
https://www.readbyqxmd.com/read/27381689/urology-pertinent-neuroendocrine-tumors-focusing-on-renal-pelvis-bladder-prostate-located-sympathetic-functional-paragangliomas
#12
EDITORIAL
C Alberti
Urology pertinent neuroendocrine neoplasias are more and more driving to research attractive contributions mainly as regards the urinary tract paragangliomas, besides the prostate cancer neuroendocrine differentiation. About such visceral sympathetic paragangliomas, a considerable attention is aroused by those concerning the renal pelvis, urinary bladder and, particularly, the prostate gland. Essential catecholamine/adrenergic signal-mediated pathophysiological implications and outlined diagnostic approaches are here taken into consideration...
March 2016: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/27287505/ovarian-cancer-laparoscopic-hysterectomy-and-staging-in-a-patient-with-history-of-intraperitoneal-renal-transplant
#13
Maria Andrikopoulou, Patrick Vetere, Farr R Nezhat
OBJECTIVE: Ovarian cancer laparoscopic staging of patient with intraperitoneal renal transplant. METHODS: 43-year-old female with intra-peritoneal renal transplant was referred status post laparoscopic bilateral ovarian cystectomies. The pathology report revealed serous adenocarcinoma with clear cell and papillary features of ovaries and endometrium. She was asymptomatic with benign examination. PET/CT of chest/abdomen/pelvis showed area of metabolic activity in left ovary and right common iliac pelvic lymph nodes...
August 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27215483/altered-expression-of-the-transcription-factor-forkhead-box-a1-foxa1-is-associated-with-poor-prognosis-in-urothelial-carcinoma-of-the-upper-urinary-tract
#14
Jay D Raman, Joshua I Warrick, Carla Caruso, Zhaohai Yang, Lauren Shuman, Richard D Bruggeman, Shahrokh Shariat, Jose A Karam, Christopher Wood, Alon Z Weizer, Mesut Remzi, Andrea Haitel, Karim Bensalah, Nathalie Rioux-Leclerq, Christian Bolenz, Marco Roscigno, Laura-Maria Krabbe, Payal Kapur, Yair Lotan, Vitaly Margulis, David J DeGraff
OBJECTIVE: To determine the prognostic significance of Forkhead Box A1 (FOXA1) expression in patients with upper tract urothelial carcinoma (UTUC) undergoing radical nephroureterectomy (RNU). MATERIALS AND METHODS: A retrospective analysis of 566 patients undergoing RNU at seven academic medical centers was performed. Tissue microarrays were subjected to immunohistochemistry using a commercially available polyclonal FOXA1 antibody. Logistic regression determined the association of FOXA1 expression with pathologic features and survival outcomes...
August 2016: Urology
https://www.readbyqxmd.com/read/27091477/epidermal-growth-factor-receptor-inhibitor-with-fluorouracil-leucovorin-and-irinotecan-as-an-alternative-treatment-for-advanced-upper-tract-urothelial-carcinoma-a-case-report
#15
Yen-Man Lu, Tsu-Ming Chien, Chih-Hung Lin, Chee-Yin Chai, Chun-Nung Huang
BACKGROUND: Currently, there is no standard salvage regimen after the failure of cisplatin-based chemotherapy for advanced urothelial carcinoma. The combination of epidermal growth factor receptor inhibitor with fluorouracil, leucovorin, and irinotecan was originally designed for the treatment of metastatic colorectal cancer. Until now, there have been no reports using this combination therapy in treating advanced upper tract urothelial carcinoma. To the best of our knowledge, this is the first report showing this possible treatment regimen for advanced upper tract urothelial carcinoma...
2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/26952913/high-grade-neuroendocrine-carcinoma-with-focal-squamous-metaplasia-of-renal-pelvis-associated-with-renal-calculus-study-of-a-case
#16
Yan-Ping Huang, Bin Chen, Xiang-Zhou Sun, Yan Guo, Shi-Cong Yang, Chun-Hua Deng, Yi-Ran Huang
Mixed neuroendocrine and non-neuroendocrine type of tumor in renal pelvis is rare and presents a high-grade malignancy. We present a case report that a 57-year-old man had no history of small cell cancer but presented a high-grade neuroendocrine carcinoma with focal squamous metaplasia and multiple stones simultaneously in the right renal pelvis. The patient underwent nephroureterocystectomy 9 months before this presentation, with evidence of multiple metastatic tumors in various parts of the body. The case of mixed neuroendocrine tumor with stones in the renal pelvis carries a poor prognosis and poses a therapeutic challenge to urologists...
May 2014: Urology Case Reports
https://www.readbyqxmd.com/read/26813841/-ring-suture-technique-for-renorrhaphy-during-partial-nephrectomy-in-the-management-of-renal-hilar-cancer
#17
Cuijian Zhang, Jianzhe Cao, Xuesong Li, Lin Yao, Wei Yu, Qian Zhang, Zhisong He, Liqun Zhou
OBJECTIVE: To evaluate the safety and efficacy of "ring suture technique" during partial nephrectomy in the management of renal cell cancer located in renal hilar. METHODS: The data of 31 patients with renal cell cancer located in renal hilar who underwent partial nephrectomy from January 2009 to January 2014 in Peking University First Hospital were collected. Of the 31 patients, 21 were male, 10 were female ranging from 48 to 75 years (average age of (58±13) years)...
November 1, 2015: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/26809509/the-effect-of-multiple-primary-rules-on-cancer-incidence-rates-and-trends
#18
Hannah K Weir, Christopher J Johnson, Kevin C Ward, Michel P Coleman
PURPOSE: An examination of multiple primary cancers can provide insight into the etiologic role of genes, the environment, and prior cancer treatment on a cancer patient's risk of developing a subsequent cancer. Different rules for registering multiple primary cancers (MP) are used by cancer registries throughout the world making data comparisons difficult. METHODS: We evaluated the effect of SEER and IARC/IACR rules on cancer incidence rates and trends using data from the SEER Program...
March 2016: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/26796327/igg4-related-inflammatory-pseudotumor-of-the-renal-pelvis-involving-renal-parenchyma-mimicking-malignancy
#19
Ho Gyun Park, Kyoung Min Kim
BACKGROUND: IgG4-related disease is a recently recognized systemic disease characterized by storiform fibrosis with infiltration of IgG4-positive plasma cells. In rare incidences, IgG4-related renal disease can present as a solitary mass lesion at renal pelvis and can pose a diagnostic challenge since these lesions mimic malignancy. Herein, we present a rare case of IgG4-related disease presenting as inflammatory pseudotumor lesion, involving the renal pelvis and also neighboring renal parenchyma...
2016: Diagnostic Pathology
https://www.readbyqxmd.com/read/26793514/transitional-cell-carcinoma-of-the-renal-pelvis-with-synchronous-ipsilateral-papillary-renal-cell-carcinoma-case-report-and-review
#20
Giuseppe Mucciardi, Alessandro Galì, Carmela D'Amico, Graziella Muscarà, Valeria Barresi, Carlo Magno
Diagnosis of synchronous primary genitourinary tumors are uncommon. Thus far, about 50 cases of synchronous renal tumors have been reported in the literature. We present for the first time a case of a 83-year-old man presenting in the same kidney two separate primary malignancies, a TCC of the renal pelvis and a papillary renal cell carcinoma Type 1. Considered the increased incidence of genitourinary tumors, in presence of a small renal tumor with hematuria, in our opinion, is necessary to pay attention to the diagnostic phase for the chance to highlight an urothelial cancer...
July 2015: Urology Case Reports
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