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https://www.readbyqxmd.com/read/29759594/liquid-chromatography-mass-spectrometry-based-metabolomics-and-lipidomics-reveal-toxicological-mechanisms-of-bisphenol-f-in-breast-cancer-xenografts
#1
Chao Zhao, Peisi Xie, Hailin Wang, Zongwei Cai
Bisphenol F (BPF) is a major alternative to bisphenol (BPA) and has been widely used. Although BPA exposure is known to generate various toxic effects, toxicity of BPF remains under-explored. A comprehensive method involving mass spectrometry (MS)-based global lipidomics and metabolomics, and matrix-assisted laser desorption/ionization-mass spectrometry (MALDI)- MS imaging (MSI) was used to study toxic effects of BPF and the underlying mechanisms on tumor metastasis-related tissues (liver and kidney) in breast cancer xenografts...
May 5, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29737959/risk-factors-for-bladder-cancer-recurrence-survival-in-patients-with-upper-tract-urothelial-carcinoma
#2
Yu-Peng Wu, Yun-Zhi Lin, Min-Yi Lin, Ting-Ting Lin, Shao-Hao Chen, Yong Wei, Qing-Shui Zheng, Xue-Yi Xue, Ning Xu
Purpose The aim of this work was to investigate the predictive factors for bladder cancer recurrence survival (BCRS) in patients with upper-tract urothelial carcinoma (UTUC). Methods We selected patients with UTUC who underwent segmental ureterectomy (Su) or nephroureterectomy (Nu) from 2004 to 2013 from the Surveillance, Epidemiology, and End Results (SEER) database. Patients with a history of intravesical therapy for bladder cancer and bladder cancer prior to the diagnosis of UTUC were excluded. We used Kaplan-Meier analysis, log-rank tests, and Cox proportional hazards model to compare overall survival, cancer-specific survival, and BCRS...
December 1, 2017: Tumori
https://www.readbyqxmd.com/read/29731801/sarcomatoid-carcinoma-of-renal-pelvis-involving-ureter-and-renal-parenchyma-with-heterologous-osteosarcomatous-differentiation-a-case-report-and-review-of-literature
#3
Bhavya P Mohan, P L Jayalakshmy, V Letha, Suresh Bhat
Sarcomatoid carcinoma is a highgrade rare malignant tumor with both epithelial and mesenchymal components. Sarcomatoid carcinoma in the upper urinary tract is very rare. We reported here a case of sarcomatoid carcinoma of renal pelvis with osteosarcomatous differentiation, with involvement of the ureter and renal parenchyma in a 68-year-old female. Histologically, predominant pleomorphic spindle cell sarcoma component with osteoid production and urothelial carcinoma component with in situ areas were identified...
2018: Iranian Journal of Pathology
https://www.readbyqxmd.com/read/29715161/renal-pelvis-carcinoma-with-renal-vein-or-inferior-vena-cava-involvement-linked-to-early-onset-lung-metastasis-based-on-ct-scan-diagnosis
#4
Tzu-Yao Liao, Chuang-Chi Liaw, Ke-Hung Tsui, Yu-Hsiang Juan
BACKGROUND/AIM: Renal pelvis cancer with invasion of the renal vein or inferior vena cava (IVC) carries a poor prognosis. The present study investigated whether early-onset lung metastasis in these patients contributes to their poor outcome. PATIENTS AND METHODS: Data were retrospectively collected from hospitalized patients with metastatic renal pelvis urothelial cancer. The parameters used to estimate the risk of lung metastasis were based on computed tomographic (CT) scans...
May 2018: Anticancer Research
https://www.readbyqxmd.com/read/29687437/coincidental-bladder-cuff-transitional-cell-carcinoma-in-nephroureterectomy-specimens-risk-factors-prognosis-and-clinical-implementation
#5
Mohamed Mohamed Elawdy, Yasser Osman, Diaa-Eldin Taha, Samer El-Halwagy, Mohsen El-Mekresh
PURPOSE: There is a lack of reporting of the bladder cuff pathology in the literature and ongoing debate regarding the role of bladder cuff excision (BCE) in the prognosis in patients with upper tract urothelial carcinoma (UTUC). We aimed to know the risk factors, the survival, and the clinical course of such pathology. MATERIALS AND METHODS: The study was retrospective, from 1983-2013 on 305 patients who had diagnosed with UTUC. Patients were managed by radical open/ laparoscopic nephroureterectomy with bladder cuff excision...
April 24, 2018: Urology Journal
https://www.readbyqxmd.com/read/29684961/-a-case-of-renal-cell-carcinoma-growing-into-the-renal-pelvis-with-a-fibrin-cap-in-the-ureter-and-bladder
#6
Tatsuro Ishikawa, Koji Izumi, Takuya Kondo, Ken Miyama, Yutaka Osada, Junnichi Ota
We present a case of renal cell carcinoma growing into the renal pelvis with a fibrin cap in the ureter and bladder. A 66-year-old man presented to our hospital with anemia and gross hematuria. Computed tomography showed a large left renal tumor and space-occupying lesions in the left renal pelvis and ureter. Cystoscopy showed a 2 cm-restiform mass protruding from the left ureteral orifice. We performed open left nephroureterectomy, and there was a 3 cm white mass with a smooth surface in the bladder. Pathological examination of the resected mass revealed clear cell carcinoma with urinary collecting system invasion and fibrin cap in the ureter and bladder...
March 2018: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/29667174/impact-of-prior-cancer-history-on-the-overall-survival-of-patients-newly-diagnosed-with-cancer-a-pan-cancer-analysis-of-the-seer-database
#7
Huaqiang Zhou, Yan Huang, Zeting Qiu, Hongyun Zhao, Wenfeng Fang, Yunpeng Yang, Yuanyuan Zhao, Xue Hou, Yuxiang Ma, Shaodong Hong, Ting Zhou, Yaxiong Zhang, Li Zhang
The population of cancer survivors with prior cancer is rapidly growing. Whether a prior cancer diagnosis interferes with outcome is unknown. We conducted a pan-cancer analysis to determine the impact of prior cancer history for patients newly diagnosed with cancer. We identified 20 types of primary solid tumors between 2004 to 2008 in the Surveillance, Epidemiology, and End Results (SEER) database. Demographic and clinicopathologic variables were compared by chi-squared test and t-test as appropriate. The propensity score-adjusted Kaplan-Meier method and Cox proportional hazards models were used to evaluate the impact of prior cancer on overall survival (OS)...
April 18, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29624636/prognostic-importance-of-lymphovascular-invasion-in-urothelial-carcinoma-of-the-renal-pelvis
#8
Matthew R Danzig, Katherine Mallin, James M McKiernan, Walter M Stadler, Srikala S Sridhar, Todd M Morgan, Bernard H Bochner, Cheryl T Lee
BACKGROUND: The current study was conducted to assess the impact of lymphovascular invasion on the survival of patients with urothelial carcinoma of the renal pelvis. METHODS: Patients with urothelial carcinoma of the renal pelvis who underwent radical nephroureterectomy from 2010 through 2015 were identified in the National Cancer Data Base. Patients were characterized according to demographic and clinical factors, including pathologic tumor stage and lymphovascular invasion...
April 6, 2018: Cancer
https://www.readbyqxmd.com/read/29606134/tgr5-expression-in-normal-kidney-and-renal-neoplasms
#9
Chaohui Lisa Zhao, Ali Amin, Yiang Hui, Dongfang Yang, Weibiao Cao
BACKGROUND: The G protein-coupled bile acid receptor (TGR5) is a cell surface receptor which induces the production of intracellular cAMP and promotes epithelial-mesenchymal transition in gastric cancer cell lines. TGR5 is found in a wide variety of tissues including the kidney. However, the patterns of TGR5 expression have not been well characterized in physiologic kidney or renal neoplasms. We explore the expression of TGR5 in benign renal tissue and renal neoplasms and assess its utility as a diagnostic marker...
April 2, 2018: Diagnostic Pathology
https://www.readbyqxmd.com/read/29534418/-application-of-narrow-band-imaging-flexible-ureteroscopy-in-the-diagnosis-treatment-and-follow-up-of-upper-tract-urothelial-carcinomas
#10
Y C Hao, C L Xiao, K Liu, Y Q Liu, L L Ma
Objective: To investigate application value of narrow-band imaging (NBI) flexible ureteroscopy in the diagnosis, treatment and follow-up of upper urinary tract transitional carcinomas (UTUC). Methods: From June 2015 to June 2017, 16 patients of UTUC were treated by flexible ureteroscopy with white light (WLI) and NBI at Department of Urology, Peking University Third Hospital , including 10 females and 6 males. The age of patients ranged from 43 to 84 years (average 68.9 years). There were 54 cases, including 16 cases with first-suspicion of cancer, and 38 cases with known of UTUC as follow-up...
March 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29520901/novel-method-for-dna-methylation-analysis-using-high-performance-liquid-chromatography-and-its-clinical-application
#11
Takuya Yotani, Yuriko Yamada, Eri Arai, Ying Tian, Masahiro Gotoh, Motokiyo Komiyama, Hiroyuki Fujimoto, Michiie Sakamoto, Yae Kanai
The aim of this study was to develop a new methodology that is suitable for DNA methylation diagnostics and to demonstrate its clinical applicability. We developed a new anion-exchange column for high-performance liquid chromatography (HPLC) with electrostatic and hydrophobic properties. Both cytosine and thymine, corresponding to methylated and unmethylated cytosine after bisulfite modification, respectively, are captured by electrostatic interaction and then discriminated from each other by their hydrophobic interactions...
March 9, 2018: Cancer Science
https://www.readbyqxmd.com/read/29487884/-ex-vivo-study-in-nephroureterectomy-specimens-defining-the-role-of-3-d-upper-urinary-tract-visualization-using-optical-coherence-tomography-and-endoluminal-ultrasound
#12
Mieke T J Bus, Paul Cernohorsky, Daniel M de Bruin, Sybren L Meijer, Geert J Streekstra, Dirk J Faber, Guido M Kamphuis, Patricia J Zondervan, Marcel van Herk, Maria P Laguna Pes, Maik J Grundeken, Martin J Brandt, Theo M de Reijke, Jean J M C H de la Rosette, Ton G van Leeuwen
Minimal invasive endoscopic treatment for upper urinary tract urothelial carcinoma (UUT-UC) is advocated in patients with low-risk disease and limited tumor volume. Diagnostic ureterorenoscopy combined with biopsy is the diagnostic standard. This study aims to evaluate two alternative diagnostic techniques for UUT-UC: optical coherence tomography (OCT) and endoluminal ultrasound (ELUS). Following nephroureterectomy, OCT, ELUS, and computed tomography (CT) were performed of the complete nephroureterectomy specimen...
January 2018: Journal of Medical Imaging
https://www.readbyqxmd.com/read/29484234/foreign-body-mimicking-neoplasia-of-the-renal-pelvis-on-magnetic-resonance-imaging
#13
Charalampos Mamoulakis, Petros Gorgoraptis, Elias Kehagias, Apostolos Karantanas
A 65-year-old male presented with an incidental magnetic resonance imaging (MRI) finding of a right renal pelvis (RP) tumor-like mass. He was subjected to nephrostomy tube (NT) placement due to hydronephrosis secondary to an impacted ureteral stone. NT was removed after successful Ho:YAG laser lithotripsy. Abdominal MRI performed 19 months later for another indication showed RP wall thickening/enhancement and an intrapelvic low-intensity linear structure presenting as a magnetic susceptibility artifact. He underwent diagnostic ureterorenoscopy/retrograde intrarenal surgery...
January 2018: Turkish Journal of Urology
https://www.readbyqxmd.com/read/29429165/-clinicopathologic-features-with-collecting-duct-carcinoma-of-kidney-report-of-10-cases
#14
J X Zhou, X R He, G X Song, Z G Zou, L H Wang, R Hu, H X Li
Objective: To study the pathological features, immunophenotypes, differential diagnoses and prognostic parameters of collecting duct carcinoma of the kidney (CDC). Methods: Clinical imaging, histopathology, immunohistochemistry, and survival data of 10 patients at First Affiliated Hospital of Nanjing Medical University from January 2009 to August 2017 were retrospectively analyzed along with a review of literatures. Results: The clinical symptoms of CDC were not specific, and image examinations showed space-occupying mass lesions...
February 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29416205/upper-urinary-tract-urothelial-cancer-in-croatian-and-bosnian-endemic-nephropathy-regions
#15
Josip Samardzic, Sefik Hasukic
Objectives: Endemic nephropathy (EN) is a chronic tubulointerstitial renal disease associated with increased incidence of upper urinary tract urothelial cancer (UTUC) occurring predominantly in geographically limited areas in villages along big Danube river. Based on results obtained by the research it is confirmed that aristolochic acid is causative agent of endemic nephropathy (EN). Aim: The aim of this study was to determine characteristics of UTUC in two endemic areas and analyze trends in 5-year period...
December 2017: Medical Archives
https://www.readbyqxmd.com/read/29343916/effects-of-tumor-size-and-location-on-survival-in-upper-tract-urothelial-carcinoma-after-nephroureterectomy
#16
Shreyas S Joshi, Laura L Quast, Sam S Chang, Sanjay G Patel
Introduction: Upper Tract Urothelial Carcinoma (UTUC) is a rare disease with few prognostic determinants. We sought to evaluate the impact of tumor size and location on patient survival following nephroureterectomy for UTUC. Materials and Methods: Data on 8284 patients treated with radical nephroureterectomy for UTUC in the United States between 1998 and 2011 were analyzed from the National Cancer Data Base. Univariable survivorship curves were generated based on pT stage, pN stage, grade, tumor size, and tumor site (renal pelvis vs...
January 2018: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/29277821/iodine-content-analysis-using-dual-energy-computed-tomography-as-a-biomarker-of-transitional-cell-carcinoma-an-experience-with-separation-of-the-clotted-blood-and-tumorous-tissue
#17
Hynek Mirka, Jan Baxa, Milan Hora, Ondrej Hes, Ondrej Topolcan, Jiri Ferda
BACKGROUND/AIM: The aim of this study was to evaluate the possibility to discriminate the blood clot from tumorous tissue in the assessment of transitional cell carcinoma (TCC), when CT data are used only from single-phase dual-energy CT (DECT). MATERIALS AND METHODS: A total of 18 patients were included into the retrospective analysis of the prospectively collected data (the average age was 67.3 years, range=62-79 years, 12 males, 6 females). DECT was performed in all patients after intravenous administration of the iodinated contrast material...
January 2018: Anticancer Research
https://www.readbyqxmd.com/read/29230948/three-dimensional-printed-model-of-bilateral-wilms-tumor-a-useful-tool-for-planning-nephron-sparing-surgery
#18
Óscar Girón-Vallejo, Darío García-Calderón, Ramón Ruiz-Pruneda, Rosa Cabello-Laureano, Ernesto Doménech-Abellán, José Luis Fuster-Soler, José I Ruiz-Jiménez
Nephron sparing surgery (NSS) is increasingly utilized to treat patients with bilateral Wilms tumor. We present a case of NSS planning using a three-dimensional computerized and printed model of both kidneys with anatomical structures of interest (parenchyma, renal pelvis, major calyx, renal artery, renal vein, and tumor). This model allowed a better understanding of the anatomic relation between the tumor and the normal kidney on each side, improving the surgical planning and the preoperative discussion with the patient's family...
April 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29211398/the-effect-of-ast-alt-de-ritis-ratio-on-survival-and-its-relation-to-tumor-histopathological-variables-in-patients-with-localized-renal-cell-carcinoma
#19
Lütfi Canat, Hasan Anil Ataly, Samir Agalarov, Ilter Alkan, Fatih Alturende
PURPOSE: To assess the relationship between De Ritis (aspartate aminotransaminase [AST]/Alanine aminotransaminase [ALT]) ratio and pathological variables and whether it is an independent prognostic factor. MATERIALS AND METHODS: We analyzed 298 consecutive patients who underwent radical or partial nephrectomy for non-metastatic renal cell carcinoma (RCC) between 2006 and 2015. The association between De Ritis ratio and pathological variables including tumor size, presence of renal vein invasion, vena cava invasion, renal capsule infiltration, Gerota fascia invasion, renal sinus involvement, renal pelvic invasion, angiolymphatic invasion, adrenal gland involvement, lymph node involvement, tumor necrosis, and Fuhrman's grade was tested...
March 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29188298/adjuvant-sandwich-chemotherapy-plus-radiotherapy-vs-adjuvant-chemotherapy-alone-for-locally-advanced-bladder-cancer-after-radical-cystectomy-a-randomized-phase-2-trial
#20
Mohamed S Zaghloul, John P Christodouleas, Andrew Smith, Ahmed Abdallah, Hany William, Hussein M Khaled, Wei-Ting Hwang, Brian C Baumann
Importance: Locoregional failure for patients with locally advanced bladder cancer (LABC) after radical cystectomy (RC) is common even with chemotherapy and is associated with high morbidity and mortality. Adjuvant radiotherapy (RT) can decrease locoregional failure but has not been studied in the chemotherapy era. Objective: To investigate if adjuvant sequential RT plus chemotherapy can improve locoregional recurrence-free survival (LRFS) compared with adjuvant chemotherapy alone...
January 17, 2018: JAMA Surgery
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