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Keywords senescence associated secretor...

senescence associated secretory phenotype

https://read.qxmd.com/read/38535306/plant-derived-senotherapeutics-for-the-prevention-and-treatment-of-intervertebral-disc-degeneration-and-aging
#1
REVIEW
Eleni Mavrogonatou, Dimitris Kletsas
Chronic low back pain, a major cause of disability with a great global socioeconomic impact, has been inextricably associated with intervertebral disc degeneration. On the other hand, an enhanced number of senescent cells has been identified in aged and degenerated intervertebral discs and their senescence-associated secretory phenotype (SASP) has been connected with qualitative/quantitative alterations in the extracellular matrix and ultimately with the disturbance of tissue homeostasis. Given that selective elimination of senescent cells (by the so-called senolytics) or amendment of their secretome towards a less catabolic/inflammatory phenotype (by molecules known as senomorphics) has been reported to alleviate symptoms of several age-associated diseases and to improve tissue quality during aging, here we will review the emerging role of senolytic and senomorphic agents derived from plants and natural products against intervertebral disc degeneration...
February 28, 2024: Metabolites
https://read.qxmd.com/read/38534794/exploring-transcriptional-regulation-of-beta-cell-sasp-by-brd4-associated-proteins-and-cell-cycle-control-protein-p21
#2
JOURNAL ARTICLE
Jasmine Manji, Jasmine Pipella, Gabriel Brawerman, Peter J Thompson
Type 1 diabetes (T1D) is a metabolic disease resulting from progressive autoimmune destruction of insulin-producing pancreatic beta cells. Although the majority of beta cells are lost in T1D, a small subset undergoes senescence, a stress response involving growth arrest, DNA damage response, and activation of a senescence-associated secretory phenotype (SASP). SASP in beta cells of the nonobese diabetic (NOD) mouse model of T1D and primary human islets is regulated at the level of transcription by bromodomain extra-terminal (BET) proteins, but the mechanisms remain unclear...
March 6, 2024: Epigenomes
https://read.qxmd.com/read/38534738/effects-of-blood-derived-products-on-cellular-senescence-and-inflammatory-response-a-study-on-skin-rejuvenation
#3
JOURNAL ARTICLE
Harald Kühnel, Markus Pasztorek, Olga Kuten-Pella, Karina Kramer, Christoph Bauer, Zsombor Lacza, Stefan Nehrer
Blood-derived products, such as citrate platelet-rich plasma (CPRP) and hyperacute serum (HAS), are recognized for their rich growth factor content. When human dermal fibroblast (HDF) cells are exposed to combined mitogenic and DNA-damaging stimuli, it can lead to an increased burden of senescent cells and a modified senescence-associated secretory phenotype. In this study, the senescent state was comprehensively assessed through various methods, including phosphorylated histone H2AX (γH2AX) staining, p21 and p16 q-PCR, p21-western blot, growth curves, and senescence-associated ß-galactosidase staining...
February 28, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534394/the-molecular-mechanisms-in-senescent-cells-induced-by-natural-aging-and-ionizing-radiation
#4
REVIEW
Milana Ibragimova, Assiya Kussainova, Akmaral Aripova, Rakhmetkazhi Bersimbaev, Olga Bulgakova
This review discusses the relationship between cellular senescence and radiation exposure. Given the wide range of ionizing radiation sources encountered by people in professional and medical spheres, as well as the influence of natural background radiation, the question of the effect of radiation on biological processes, particularly on aging processes, remains highly relevant. The parallel relationship between natural and radiation-induced cellular senescence reveals the common aspects underlying these processes...
March 21, 2024: Cells
https://read.qxmd.com/read/38534362/repurposing-drugs-for-senotherapeutic-effect-potential-senomorphic-effects-of-female-synthetic-hormones
#5
JOURNAL ARTICLE
Laura R Bramwell, Ryan Frankum, Lorna W Harries
Repurposing previously approved drugs may fast track the route to the clinic for potential senotherapeutics and improves the inefficiency of the clinical drug development pipeline. We performed a repurposing screen of 240 clinically approved molecules in human primary dermal fibroblasts for their effects on CDKN2A expression. Molecules demonstrating effects on CDKN2A expression underwent secondary screening for senescence-associated beta galactosidase (SAB) activity, based on effect size, direction, and/or molecule identity...
March 15, 2024: Cells
https://read.qxmd.com/read/38533417/causal-relationship-between-telomere-length-and-risk-of-intracranial-aneurysm-a-bidirectional-mendelian-randomization-study
#6
JOURNAL ARTICLE
Bangjie Xu, Jiangbin Ren, Siqi Zhu, Yu Ding, Wei Zhou, Qing Guo, Yan Fang, Jing Zheng
BACKGROUND: Telomere length is closely linked to the aging phenotype, where cellular aging results in the production of a cascade of cell factors and the senescence-associated secretory phenotype (SASP), leading to an inflammatory response. The presence of inflammation plays a crucial role in the formation of intracranial aneurysms. Nevertheless, the relationship between telomere length and intracranial aneurysms remains unclear. This study aims to explore the causal connection between telomere length and intracranial aneurysms through the utilization of Mendelian randomization (MR) analysis...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38530804/senescent-adipocytes-and-type-2-diabetes-current-knowledge-and-perspective-concepts
#7
REVIEW
Weronika Kruczkowska, Julia Gałęziewska, Mateusz Kciuk, Adrianna Gielecińska, Elżbieta Płuciennik, Zbigniew Pasieka, Lin-Yong Zhao, Yi-Jin Yu, Damian Kołat, Żaneta Kałuzińska-Kołat
Among civilization diseases, the number of individuals suffering from type 2 diabetes (T2DM) is expected to increase to more than a billion in less than 20 years, which is associated with, e.g., populational aging, poor diet, sedentary lifestyle, genetic predispositions, and immunological factors. T2DM affects many organs and is characterized by insulin resistance, high glucose levels, and adipocyte dysfunction, which are related to senescence. Although this type of cellular aging has beneficial biological functions, it can also act unfavorable since senescent adipocytes resist apoptosis, enhance cytokine secretion, downregulate cell identity genes, and acquire the senescence-associated secretory phenotype that renders a more oxidative environment...
January 1, 2024: Biomolecular Concepts
https://read.qxmd.com/read/38528029/kdm6a-cnn1-axis-orchestrates-epigenetic-control-of-trauma-induced-spinal-cord-microvascular-endothelial-cell-senescence-to-balance-neuroinflammation-for-improved-neurological-repair
#8
JOURNAL ARTICLE
Chengjun Li, Tian Qin, Jinyun Zhao, Yuxin Jin, Yiming Qin, Rundong He, Tianding Wu, Chunyue Duan, Liyuan Jiang, Feifei Yuan, Hongbin Lu, Yong Cao, Jianzhong Hu
Cellular senescence assumes pivotal roles in various diseases through the secretion of proinflammatory factors. Despite extensive investigations into vascular senescence associated with aging and degenerative diseases, the molecular mechanisms governing microvascular endothelial cell senescence induced by traumatic stress, particularly its involvement in senescence-induced inflammation, remain insufficiently elucidated. In this study, we present a comprehensive demonstration and characterization of microvascular endothelial cell senescence induced by spinal cord injury (SCI)...
March 25, 2024: Bone Research
https://read.qxmd.com/read/38522384/cytokine-profiling-in-senescent-and-reactive-astrocytes-a-systematic-review
#9
REVIEW
Michel López-Teros, Adriana Alarcón-Aguilar, Alejandra Castillo-Aragón, Mina Königsberg, Armando Luna-López
Astrocytes play an important role in neuroinflammation by producing proinflammatory molecules. In response to various stressful stimuli, astrocytes can become senescent or reactive, both are present in age-associated cognitive impairment and other neurodegenerative diseases, and contribute to neuroinflammation. However, there are no studies that compare the cytokines secreted by these types of astrocytes in the brain during aging. Hence, we aimed to broaden the picture of the secretory profiles and to differentiate the variability between them...
February 27, 2024: Neurobiology of Aging
https://read.qxmd.com/read/38522236/growth-and-differentiation-factor-15-a-link-between-inflammaging-and-cardiovascular-disease
#10
REVIEW
Balázs Bence Nyárády, Loretta Zsuzsa Kiss, Zsolt Bagyura, Béla Merkely, Edit Dósa, Orsolya Láng, László Kőhidai, Éva Pállinger
Age-related disorders are closely linked to the accumulation of senescent cells. The senescence-associated secretory phenotype (SASP) sustains and progresses chronic inflammation, which is involved in cellular and tissue dysfunction. SASP-related growth and differentiation factor-15 (GDF-15) is an immunoregulatory cytokine that is coupled to aging and thus may have a regulatory role in the development and maintenance of atherosclerosis, a major cause of cardiovascular disease (CVD). Although the effects of GDF-15 are tissue-specific and dependent on microenvironmental changes such as inflammation, available data suggest that GDF-15 has a significant role in CVD...
March 23, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38516126/senescence-and-fibrosis-in-salivary-gland-aging-and-disease
#11
JOURNAL ARTICLE
Deirdre A Nelson, Isabella Kazanjian, J Andres Melendez, Melinda Larsen
Salivary gland hypofunction is highly prevalent in aged and diseased individuals leading to significant discomfort and morbidity. One factor that contributes to salivary gland hypofunction is cellular aging, or senescence. Senescent cells can impair gland function by secreting paracrine-acting growth factors and cytokines, known as senescence-associated secretory phenotype (SASP) factors. These SASP factors stimulate inflammation, propagate the senescent phenotype through the bystander effect, and stimulate fibrosis...
2024: Journal of Oral Biology and Craniofacial Research
https://read.qxmd.com/read/38515112/aurkb-promotes-bladder-cancer-progression-by-deregulating-the-p53-dna-damage-response-pathway-via-mad2l2
#12
JOURNAL ARTICLE
Linzhi Li, Pengcheng Jiang, Weimin Hu, Fan Zou, Ming Li, Ting Rao, Yuan Ruan, Weimin Yu, Jinzhuo Ning, Fan Cheng
BACKGROUND: Bladder cancer (BC) is the most common urinary tract malignancy. Aurora kinase B (AURKB), a component of the chromosomal passenger protein complex, affects chromosomal segregation during cell division. Mitotic arrest-deficient 2-like protein 2 (MAD2L2) interacts with various proteins and contributes to genomic integrity. Both AURKB and MAD2L2 are overexpressed in various human cancers and have synergistic oncogenic effects; therefore, they are regarded as emerging therapeutic targets for cancer...
March 21, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38514923/topical-bcl-2-inhibitor-abt-737-attenuates-skin-photoaging-in-mice
#13
JOURNAL ARTICLE
Bingyi Yang, Jiao Jiang, Haijing Wu, Qianjin Lu
No abstract text is available yet for this article.
March 2024: Experimental Dermatology
https://read.qxmd.com/read/38504990/t-cell-immunity-against-senescence-potential-role-and-perspectives
#14
REVIEW
Kseniia Matveeva, Mariia Vasilieva, Ekaterina Minskaia, Stanislav Rybtsov, Daniil Shevyrev
The development of age-associated diseases is related to the accumulation of senescent cells in the body. These are old non-functional cells with impaired metabolism, which are unable to divide. Such cells are also resistant to programmed cell death and prone to spontaneous production of some inflammatory factors. The accumulation of senescent cells is related to the age-associated dysfunction of organs and tissues as well as chronic inflammation that enhances with age. In the young organism, senescent cells are removed with the innate immunity system...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38499288/cellular-senescence-promotes-meibomian-gland-dysfunction-in-a-chronic-graft-versus-host-disease-mouse-model
#15
JOURNAL ARTICLE
Shinri Sato, Yoko Ogawa, Eisuke Shimizu, Kazuki Asai, Takahiro Okazaki, Robert Rusch, Masatoshi Hirayama, Shigeto Shimmura, Kazuno Negishi, Kazuo Tsubota
PURPOSE: Aging is a well-established risk factor for meibomian gland dysfunction (MGD). We previously reported an accelerated cellular senescence phenomenon in the lacrimal glands of a murine model of chronic graft-versus-host disease (cGVHD). Herein, we aimed to elucidate the relationship between cellular senescence and MGD in cGVHD mice, utilizing the senolytic agent ABT-263. METHODS: A cGVHD mouse model was established through allogeneic bone marrow transplantation (BMT) from B10...
March 16, 2024: Ocular Surface
https://read.qxmd.com/read/38496401/associations-of-systemic-inflammation-and-senescent-cell-biomarkers-with-clinical-outcomes-in-older-adults-with-schizophrenia
#16
M K Kirsten Chui, Kevin Schneider, Katherine Miclau, Sara C LaHue, David Furman, Heather Leutwyler, John C Newman
Individuals with schizophrenia suffer from higher morbidity and mortality throughout life partly due to acceleration of aging-related diseases and conditions. Systemic inflammation is a hallmark of aging and is also observed in schizophrenia. An improved understanding of how inflammation and accelerated aging contribute to long-term health outcomes in schizophrenia could provide more effective treatments to preserve long-term cognitive and physical function. In this pilot cross-sectional study, 24 older adults (≥55 years old) with schizophrenia were assessed on symptoms (Positive and Negative Syndrome Scale), neurocognition (Matrics Consensus Cognitive Battery), mobility (Timed Get Up and Go), and general health (SF-12)...
March 8, 2024: medRxiv
https://read.qxmd.com/read/38495743/mechanisms-and-therapeutic-strategies-for-senescence-associated-secretory-phenotype-in-the-intervertebral-disc-degeneration-microenvironment
#17
REVIEW
Yang Liu, Yiming Dou, Xun Sun, Qiang Yang
UNLABELLED: As a permanent state of cell cycle arrest, cellular senescence has become an important factor in aging and age-related diseases. As a central regulator of physiology and pathology associated with cellular senescence, the senescence associated secretory phenotype can create an inflammatory and catabolic environment through autocrine and paracrine ways, ultimately affecting tissue microstructure. As an age-related disease, the correlation between intervertebral disc degeneration and cellular senescence has been confirmed by many studies...
March 2024: Journal of Orthopaedic Translation
https://read.qxmd.com/read/38494091/senolytic-therapeutics-an-emerging-treatment-modality-for-osteoarthritis
#18
REVIEW
Md Meraj Ansari, Mrinmoy Ghosh, Dong-Sun Lee, Young-Ok Son
Osteoarthritis (OA), a chronic joint disease affecting millions of people aged over 65 years, is the main musculoskeletal cause of diminished joint mobility in the elderly. It is characterized by lingering pain and increasing deterioration of articular cartilage. Aging and accumulation of senescent cells (SCs) in the joints are frequently associated with OA. Apoptosis resistance; irreversible cell cycle arrest; increased p16INK4a expression, secretion of senescence-associated secretory phenotype factors, senescence-associated β-galactosidase levels, secretion of extracellular vesicles, and levels of reactive oxygen and reactive nitrogen species; and mitochondrial dysregulation are some common changes in cellular senescence in joint tissues...
March 15, 2024: Ageing Research Reviews
https://read.qxmd.com/read/38482753/mitophagy-defect-mediates-the-aging-associated-hallmarks-in-hutchinson-gilford-progeria-syndrome
#19
JOURNAL ARTICLE
Yingying Sun, Le Xu, Yi Li, Shunze Jia, Gang Wang, Xufeng Cen, Yuyan Xu, Zhongkai Cao, Jingjing Wang, Ning Shen, Lidan Hu, Jin Zhang, Jianhua Mao, Hongguang Xia, Zhihong Liu, Xudong Fu
Hutchinson-Gilford progeria syndrome (HGPS) is a rare and fatal disease manifested by premature aging and aging-related phenotypes, making it a disease model for aging. The cellular machinery mediating age-associated phenotypes in HGPS remains largely unknown, resulting in limited therapeutic targets for HGPS. In this study, we showed that mitophagy defects impaired mitochondrial function and contributed to cellular markers associated with aging in mesenchymal stem cells derived from HGPS patients (HGPS-MSCs)...
March 14, 2024: Aging Cell
https://read.qxmd.com/read/38481803/wtap-mediated-n6-methyladenosine-rna-modification-of-elf3-drives-cellular-senescence-by-upregulating-irf8
#20
JOURNAL ARTICLE
Lei Zhou, Yun Zhong, Fan Wang, Yi Guo, Rui Mao, Hongfu Xie, Yiya Zhang, Ji Li
N6-methyladenosine (m6A), the most prevalent posttranscriptional RNA modification, involved in various diseases and cellular processes. However, the underlying mechanisms of m6A regulation in skin aging are still not fully understood. In this study, proteomics analysis revealed a significant correlation between Wilms' tumor 1-associating protein (WTAP) expression and cellular senescence. Next, upregulated WTAP was detected in aging skin tissues and senescent human dermal fibroblasts (HDFs). Functionally, overexpressed WTAP induced senescence and knockdown of WTAP rescued senescence of HDFs...
2024: International Journal of Biological Sciences
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