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Mitra clip

Mehmet Cilingiroglu, Konstantinos Marmagkiolis
Transesophageal echocardiography (TEE) assessment after MitraClip implantation is limited by unequal orifices and jets, eccentric regurgitation, and the acute change of the annulus geometry. Periprocedural real-time invasive hemodynamic assessment of the mitral valve function requires experience in hemodynamic monitoring interpretation. However, it provides excellent accuracy as it does not take into account the changes of the mitral apparatus geometry and jet direction after MitraClip placement. While we seek to expand indications of Mitraclip to other patient subgroups, we should consider routine ancillary invasive hemodynamic assessment, in order to optimize our understanding, procedural results...
December 2016: Catheterization and Cardiovascular Interventions
Konstantinos Marmagkiolis, Mehmet Cilingiroglu
MitraClip implantation yields low in-patient MACCE even in higher-risk patients. Bleeding and vascular complications remain the most important procedural related complications. Development of smaller caliber devices, investigation of alternative access techniques to improve safety and better patient selection are needed to optimize the outcomes of this procedure.
October 2015: Catheterization and Cardiovascular Interventions
Giuseppe D'Ancona, Hüseyin Ince, Jasmin Ortak, Yannik Stoeckicht, Stephan Kische
A case is reported of iatrogenic mitral valve chordal rupture occurring during transcatheter aortic valve implantation (TAVI) with an inflatable and repositionable valve (Direct Flow; Direct Flow Medical, Santa Rosa, CA, USA). The specific implantation technique requires initial valve advancement into the left ventricular cavity, valve inflation within the ventricular cavity, and a final finely tuned valve upward pulling through the left ventricular outflow tract until contact with the aortic annulus is achieved...
March 2015: Journal of Heart Valve Disease
Chen-Ching Lin, Wei Jiang, Ramkrishna Mitra, Feixiong Cheng, Hui Yu, Zhongming Zhao
Transcription factors (TFs) and microRNAs (miRNAs) form a gene regulatory network (GRN) at the transcriptional and post-transcriptional level in living cells. However, this network has not been well characterized, especially in regards to the mutual regulations between TFs and miRNAs in cancers. In this study, we collected those regulations inferred by ChIP-Seq or CLIP-Seq to construct the GRN formed by TFs, miRNAs, and target genes. To increase the reliability of the proposed network and examine the regulation activity of TFs and miRNAs, we further incorporated the mRNA and miRNA expression profiles in seven cancer types using The Cancer Genome Atlas data...
2015: Scientific Reports
Sanghamitra Bandyopadhyay, Dip Ghosh, Ramkrishna Mitra, Zhongming Zhao
MicroRNA (miRNA) regulates gene expression by binding to specific sites in the 3'untranslated regions of its target genes. Machine learning based miRNA target prediction algorithms first extract a set of features from potential binding sites (PBSs) in the mRNA and then train a classifier to distinguish targets from non-targets. However, they do not consider whether the PBSs are functional or not, and consequently result in high false positive rates. This substantially affects the follow up functional validation by experiments...
2015: Scientific Reports
Sayantanava Mitra, S Haque Nizamie, Nishant Goyal, Sai Krishna Tikka
BACKGROUND: The 'mirror-neuron system' is thought to play an important role in automatic decoding of biological motions and interpretation of socially adaptive environmental stimuli. Accordingly, a dysfunction in this system in schizophrenia has been hypothesised to mediate the psychotic manifestations. MATERIALS AND METHODS: As a part of an ongoing study, we evaluated the mirror neuron system using 'EEG mu-wave (8-13 Hz) suppression' paradigm in 15 drug naïve/drug free patients and compared the working to 15 age, sex and education matched controls...
July 2014: Indian Journal of Psychological Medicine
(no author information available yet)
No abstract text is available yet for this article.
December 23, 2013: Medical Letter on Drugs and Therapeutics
P Boekstegers, J Hausleiter, S Baldus, R S von Bardeleben, H Beucher, C Butter, O Franzen, R Hoffmann, H Ince, K H Kuck, V Rudolph, U Schäfer, W Schillinger, N Wunderlich
The interventional treatment of mitral valve regurgitation by the MitraClip procedure has grown rapidly in Germany and Europe during the past years. The MitraClip procedure has the potential to treat high-risk patients with secondary mitral valve regurgitation and poor left ventricular function. Furthermore, patients with primary mitral valve regurgitation may be treated successfully by the MitraClip procedure in case of high surgical risk or in very old patients. At the same time it has been emphasised that the MitraClip interventional treatment is still at an early stage of clinical development...
February 2014: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
Konstantinos Marmagkiolis, Mehmet Cilingiroglu
No abstract text is available yet for this article.
October 12, 2013: International Journal of Cardiology
James Cockburn, Paraskevi Fragkou, David Hildick-Smith
We report the first case of mitral stenosis following Mitra-Clip insertion in a patient with symptomatic NYHA IV heart failure, secondary to severe mitral regurgitation (MR). A 79-year-old female with a history of prior aortic valve replacement underwent percutaneous mitral valve (MV) repair. A single clip was advanced coaxially down onto the MV under TOE guidance, with the anterior and posterior leaflets clipped together between A2 and P2. TOE confirmed a significant reduction in MR (grade 4 to grade 1). Despite initial symptomatic relief, she represented 3 months later with similar symptoms...
February 2014: Catheterization and Cardiovascular Interventions
Justin F Fraser, Howard Riina, Nandita Mitra, Y Pierre Gobin, Arlene Stolper Simon, Philip E Stieg
OBJECTIVE: The outcomes reported in the International Subarachnoid Aneurysm Trial (ISAT), a multicenter, prospective, randomized trial to directly compare surgical clipping with endovascular coiling as treatments for ruptured intracranial aneurysms, have been misinterpreted by many to indicate the superiority of coiling to surgical clipping in all instances. To better understand the results of ISAT and their implications for practice patterns, we compared the ISAT results with the results of other published studies regarding the treatment of ruptured intracranial aneurysms...
December 2006: Neurosurgery
O Tchernichovski, T J Lints, S Deregnaucourt, A Cimenser, P P Mitra
Current technology makes it possible to measure song development continuously throughout a vocal ontogeny. Here we briefly review some of the problems involved and describe experimental and analytic methods for automatic tracing of vocal changes. These techniques make it possible to characterize the specific methods the bird uses to imitate sounds: an automated song recognition procedure allows continuous song recording, followed by automated sound analysis that partition the song to syllables, extract acoustic features of each syllable, and summarize the entire song development process over time into a single database...
June 2004: Annals of the New York Academy of Sciences
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