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https://www.readbyqxmd.com/read/29306054/tyrosine-phosphorylation-determines-afterdischarge-initiation-by-regulating-an-ionotropic-cholinergic-receptor
#1
Sean H White, Raymond M Sturgeon, Yueling Gu, Alysha Nensi, Neil S Magoski
Changes to neuronal activity often involve a rapid and precise transition from low to high excitability. In the marine snail, Aplysia, the bag cell neurons control reproduction by undergoing an afterdischarge, which begins with synaptic input releasing acetylcholine to open an ionotropic cholinergic receptor. Gating of this receptor causes depolarization and a shift from silence to continuous action potential firing, leading to the neuroendocrine secretion of egg-laying hormone and ovulation. At the onset of the afterdischarge, there is a rise in intracellular Ca2+, followed by both protein kinase C (PKC) activation and tyrosine dephosphorylation...
January 3, 2018: Neuroscience
https://www.readbyqxmd.com/read/29301980/mir-210-and-gpd1l-regulate-edn2-in-primary-and-immortalized-human-granulosa-lutein-cells
#2
Ketan Shrestha, Adepeju Esther Onasanya, Iris Eisenberg, Noa Wigoda, Simcha Yagel, Ronit Yalu, Rina Meidan, Tal Imbar
Endothelin-2 (EDN2), expressed at a narrow window during the periovulatory period, critically affects ovulation and corpus luteum (CL) formation. LH (acting mainly via cAMP) and hypoxia are implicated in CL formation; therefore, we aimed to elucidate how these signals regulate EDN2 using human primary (hGLCs) and immortalized (SVOG) granulosa-lutein cells. The hypoxiamiR, microRNA-210 (miR-210) was identified as a new essential player in EDN2 expression. Hypoxia (either mimetic compound-CoCl2, or low O2) elevated hypoxia inducible factor 1A (HIF1A), miR-210, and EDN2...
January 4, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29300975/new-application-of-dydrogesterone-as-a-part-of-a-progestin-primed-ovarian-stimulation-protocol-for-ivf-a-randomized-controlled-trial-including-516-first-ivf-icsi-cycles
#3
Sha Yu, Hui Long, Hannah Ya-Ning Chang, Yali Liu, Hongyuan Gao, Jing Zhu, Xinxin Quan, Qifeng Lyu, Yanping Kuang, Ai Ai
STUDY QUESTION: Can dydrogesterone (DYG) be used as an alternative progestin in a progesterone primed ovarian stimulation (PPOS) protocol? SUMMARY ANSWER: DYG can be used as an appropriate alternative progestin in a PPOS protocol. WHAT IS KNOWN ALREADY: PPOS is a new ovarian stimulation regimen based on a freeze-all strategy that uses progestin as an alternative to a GnRH analog for suppressing a premature LH surge during the follicular phase...
December 29, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29259450/phase-iii-trial-comparing-the-efficacy-and-safety-of-recombinant-or-urine-derived-human-chorionic-gonadotropin-for-ovulation-triggering-in-japanese-women-diagnosed-with-anovulation-or-oligo-ovulation-and-undergoing-ovulation-induction-with-follitropin-alfa
#4
Hideyuki Ikenaga, Yudai Tanaka, Masahide Shiotani, Daniela Rogoff, Shin Shimizu, Osamu Ishihara, Yoshiaki Sato, Yoshiharu Morimoto, Aisaku Fukuda, Kohzo Aisaka, Koji Yoshida, Naoki Hayashi, Hirotsugu Oku, Yuji Abe, Atsushi Haruki, Motoharu Ishikawa, Takeshi Kuramoto
Aim: Outside of Japan, recombinant-human chorionic gonadotropin (r-hCG) is widely used for the induction of final follicular maturation and early luteinization in women undergoing ovulation induction; whereas in Japan, urine-derived hCG (u-hCG) is predominantly used. The primary objective of this study was to demonstrate the non-inferiority of r-hCG to u-hCG for ovulation induction, as assessed by the ovulation rate. Methods: This was an open-label, parallel-group, randomized, multicenter, phase III trial in Japanese women with anovulation or oligo-ovulation secondary to hypothalamic-pituitary dysfunction or polycystic ovary syndrome, undergoing ovulation induction with recombinant-human follicle-stimulating hormone...
January 2017: Reproductive Medicine and Biology
https://www.readbyqxmd.com/read/29203384/do-endometriomas-grow-during-ovarian-stimulation-for-assisted-reproduction-a-three-dimensional-volume-analysis-before-and-after-ovarian-stimulation
#5
Ayse Seyhan, Bulent Urman, Engin Turkgeldi, Baris Ata
Whether endometriomas grow because of supraphysiological oestradiol levels attained during ovarian stimulation for assisted reproduction techniques is a concern. In this prospective study, 25 women with 28 endometriomas underwent three-dimensional ultrasound using sono-automated volume calculation software. Endometrioma volume was measured on the first day of gonadotrophin injection (V1) and the day of ovulation trigger (V2). Nine (36%) women were stimulated in a gonadotrophin releasing hormone antagonist protocol (GnRH), 13 (52%) in a long, and three (12%) in an ultra-long GnRH agonist protocol...
November 17, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29182200/-epigenetics-of-polycystic-ovary-syndrome
#6
REVIEW
Francisca Concha C, Teresa Sir P, Sergio E Recabarren, Francisco Pérez B
Polycystic ovarian syndrome (PCOS) is an endocrine and metabolic dysfunction, highly prevalent in women in their reproductive years. Hyperandrogenism, oligo-ovulation, polycystic ovarian morphology are the main features of this syndrome. PCOS is a genetic disorder with a multifactorial etiology and has a strong link with environmental components. It is frequently associated with obesity and insulin resistance. Recently, epigenetic mechanisms have been involved in the pathogenesis of PCOS. Several studies showed that methylation in DNA and miRNAs is altered in women with PCOS in blood, serum, adipose tissue, granulose cells and theca...
July 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/29180629/transcriptome-profile-analysis-reveals-the-regulation-mechanism-of-floral-sex-differentiation-in-jatropha-curcas-l
#7
Wenkai Hui, Yuantong Yang, Guojiang Wu, Changcao Peng, Xiaoyang Chen, Mohamed Zaky Zayed
The seeds of Jatropha curcas contain a high percentage of biodiesel. However, low seed yield which was limited by its poor female flowers was a bottleneck for its utilization. Here, we compared the transcriptomic profiles of five different samples during floral sex differentiation stages using Illumina Hiseq 4000. Our results showed that hundreds of differentially expressed genes (DEGs) were detected in floral sex initiation period, but thousands of DEGs were involved in the stamens and ovules development process...
November 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29177238/comparing-the-effect-of-gonadotropin-releasing-hormone-agonist-and-human-chorionic-gonadotropin-on-final-oocytes-for-ovulation-triggering-among-infertile-women-undergoing-intrauterine-insemination-an-rct
#8
Robabeh Taheripanah, Marzieh Zamaniyan, Atefeh Moridi, Anahita Taheripanah, Narges Malih
Background: The purpose of triggering in ovulation induction is to induce the final maturation of oocytes and their release from the ovary for fertilization. Objective: The aim of the present study was to compare the effectiveness of gonadotropin-releasing hormone (GnRH) agonist and human chorionic gonadotropin (HCG) on the final maturation of oocytes and pregnancy rates in intrauterine insemination (IUI) cycles. Materials and Methods: In this randomized clinical trial, 110 infertile women who were selected for IUI entered the study...
June 2017: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29142445/a-study-of-controlled-ovarian-stimulation-with-clomiphene-citrate-or-letrozole-in-combination-with-gonadotropins-and-iui-in-unexplained-infertility
#9
Madhusmita Hembram, Ratna Biswas, Anju Jain
Aim: To compare the effect of clomiphene citrate (CC) + human menopausal gonadotropin (hMG) with letrozole + hMG on size, number of follicles, endometrial thickness, serum levels of oestradiol and progesterone and pregnancy rate. Settings and Design: Non-randomised interventional study. Patients and Methods: A total number of 60 patients in the age group of 20-35 years with unexplained infertility were divided into two groups, 30 in each. Group A received CC + hMG and group B received letrozole + hMG...
July 2017: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/29114074/glutamatergic-transmission-to-hypothalamic-kisspeptin-neurons-is-differentially-regulated-by-estradiol-through-estrogen-receptor-%C3%AE-in-adult-female-mice
#10
Luhong Wang, Laura L Burger, Megan L Greenwald-Yarnell, Martin G Myers, Suzanne M Moenter
Estradiol feedback regulates gonadotropin-releasing hormone (GnRH) neurons and subsequent luteinizing hormone (LH) release. Estradiol acts through estrogen receptor α (ERα)-expressing afferents of GnRH neurons including kisspeptin neurons in the anteroventral periventricular (AVPV) and arcuate nuclei, providing homeostatic feedback on episodic GnRH/LH release as well as positive feedback to control ovulation. Ionotropic glutamate receptors are important for estradiol feedback but it is not known where they fit in the circuitry...
November 7, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29098117/human-chorionic-gonadotropin-mediated-generation-of-reactive-oxygen-species-is-sufficient-to-induce-meiotic-exit-but-not-apoptosis-in-rat-oocytes
#11
Meenakshi Tiwari, Shail K Chaube
Generation of reactive oxygen species (ROS) is associated with final stages of follicular development and ovulation in mammals. The human chorionic gonadotropin (hCG) mimics the action of luteinizing hormone and triggers follicular development and ovulation. However, it remains unclear whether hCG induces generation of ROS, if yes, whether hCG-mediated increased level of ROS could induce meiotic exit and/or apoptosis in rat oocytes. For this purpose, cumulus-oocyte complexes (COCs) were collected from ovary of experimental rats injected with 20 IU pregnant mare's serum gonadotropin for 48 h followed by 20 IU hCG for 0, 7, 14, and 21 h...
2017: BioResearch Open Access
https://www.readbyqxmd.com/read/29080908/gid1-expression-is-associated-with-ovule-development-of-sexual-and-apomictic-plants
#12
Luciana Gomes Ferreira, Diva Maria de Alencar Dusi, André Southernman Teixeira Irsigler, Ana Cristina Meneses Mendes Gomes, Marta Adelina Mendes, Lucia Colombo, Vera Tavares de Campos Carneiro
BbrizGID1 is expressed in the nucellus of apomictic Brachiaria brizantha, previous to aposporous initial differentiation. AtGID1a overexpression triggers differentiation of Arabidopsis thaliana MMC-like cells, suggesting its involvement in ovule development. GIBBERELLIN-INSENSITIVE DWARF1 (GID1) is a gibberellin receptor previously identified in plants and associated with reproductive development, including ovule formation. In this work, we characterized the Brachiaria brizantha GID1 gene (BbrizGID1). BbrizGID1 showed up to 92% similarity to GID1-like gibberellin receptors of other plants of the Poaceae family and around 58% to GID1-like gibberellin receptors of Arabidopsis thaliana...
October 28, 2017: Plant Cell Reports
https://www.readbyqxmd.com/read/29038356/local-production-of-neurostradiol-affects-gonadotropin-releasing-hormone-gnrh-secretion-at-mid-gestation-in-lagostomus-maximus-rodentia-caviomorpha
#13
Santiago E Charif, Pablo I F Inserra, Alejandro R Schmidt, Noelia P Di Giorgio, Santiago A Cortasa, Candela R Gonzalez, Victoria Lux-Lantos, Julia Halperin, Alfredo Daniel Vitullo, Verónica B Dorfman
Females of the South American plains vizcacha, Lagostomus maximus, show peculiar reproductive features such as massive polyovulation up to 800 oocytes per estrous cycle and an ovulatory process around mid-gestation arising from the reactivation of the hypothalamic-hypophyseal-ovary (H.H.O.) axis. Estradiol (E2) regulates gonadotropin-releasing hormone (GnRH) expression. Biosynthesis of estrogens results from the aromatization of androgens by aromatase, which mainly occurs in the gonads, but has also been described in the hypothalamus...
October 2017: Physiological Reports
https://www.readbyqxmd.com/read/29025011/significance-of-epidermal-growth-factor-receptor-signaling-for-acquisition-of-meiotic-and-developmental-competence-in-mammalian-oocytes
#14
Radek Prochazka, Milan Blaha, Lucie Nemcová
The surge in luteinizing hormone (LH) in preovulatory ovarian follicles triggers the resumption of oocyte meiosis accompanied by expansion of surrounding cumulus cells and ovulation of cumulus-oocyte complexes (COCs) into the oviduct. Over the last 15 years, substantial progress has been made in elucidating the key pathways by which the LH signal spreads within the preovulatory follicle and in identifying the molecules responsible for maintaining oocyte arrest and meiosis resumption. It is now clear that the adenylcyclase-mediated rise in intracellular cyclic adenosine monophosphate leads to activation of the epidermal growth factor receptor (EGFR) network in granulosa and cumulus cells...
October 1, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28993105/dual-trigger-of-final-oocyte-maturation-in-poor-ovarian-responders-undergoing-ivf-icsi-cycles
#15
Jie Zhang, Yun Wang, Xiaoyan Mao, Qiuju Chen, Qingqing Hong, Renfei Cai, Shaozhen Zhang, Yanping Kuang
Previous studies show that a dual trigger ovulation regimen significantly improves number and maturity of retrieved oocytes for normal ovarian responders or patients with history of low oocyte yield. The current retrospective cohort study investigated whether dual trigger of final oocyte maturation may benefit IVF outcomes for poor ovarian responders fulfilling the Bologna criteria. Undertaken between May 2014 and August 2016, the study involved 1350 patients undergoing 1389 IVF/intracytoplasmic sperm injection treatment cycles...
December 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28992179/overexpression-of-the-class-d-mads-box-gene-sl-agl11-impacts-fleshy-tissue-differentiation-and-structure-in-tomato-fruits
#16
Baowen Huang, Jean-Marc Routaboul, Mingchun Liu, Wei Deng, Elie Maza, Isabelle Mila, Guojian Hu, Mohamed Zouine, Pierre Frasse, Julia T Vrebalov, James J Giovannoni, Zhengguo Li, Benoît van der Rest, Mondher Bouzayen
MADS-box transcription factors are key elements of the genetic networks controlling flower and fruit development. Among these, the class D clade gathers AGAMOUS-like genes which are involved in seed, ovule, and funiculus development. The tomato genome comprises two class D genes, Sl-AGL11 and Sl-MBP3, both displaying high expression levels in seeds and in central tissues of young fruits. The potential effects of Sl-AGL11 on fruit development were addressed through RNAi silencing and ectopic expression strategies...
October 13, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28985546/ovulation-induction-and-controlled-ovarian-stimulation-using-letrozole-gonadotropin-combination-a-single-center-retrospective-cohort-study
#17
Sushila Arya, Sanja Kupesic-Plavsic, Zuber D Mulla, Alok K Dwivedi, Zeni Crisp, Jisha Jose, Luis S Noble
OBJECTIVE: To assess the effect of letrozole in combination with low dose gonadotropins for ovulation induction in anovulatory infertility from polycystic ovary syndrome (PCOS) and controlled ovarian stimulation for endometriosis, and unexplained infertility patients. STUDY DESIGN: Retrospective cohort study in a setting of private Reproductive Endocrinology and Infertility Clinic affiliated with the University. Three hundred couples (650 cycles) requiring OI/COS for PCOS (92 patients, 195 cycles), endometriosis (89 patients, 217 cycles), and unexplained infertility (119 patients, 238 cycles)...
November 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28965551/modified-natural-cycle-in-in%C3%A2-vitro-fertilization
#18
REVIEW
Jacqueline R Ho, Richard J Paulson
The first live birth after IVF was achieved in a purely natural cycle. Because early attempts at IVF were associated with low efficiency, ovarian stimulation was added to achieve a greater margin for error in oocyte retrieval, fertilization, and thus, overall pregnancy success. As technology improved, the intuitive appeal of the natural cycle led investigators to once again attempt IVF without antecedent gonadotropin stimulation. Triggering of ovulation with hCG was added to allow for accurate scheduling of oocyte retrieval and thus increased oocyte yield...
October 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28965278/the-value-of-delaying-hcg-administration-to-enable-maturation-of-medium-sized-follicles-in-patients-undergoing-superovulation-for-ivf-icsi
#19
Awoniyi O Awonuga, Karen Wheeler, Mili Thakur, Roohi Jeelani, Michael P Diamond, Elizabeth E Puscheck
PURPOSE: The purpose of the study is to determine whether continued stimulation of mature follicles to allow "catch up" growth of medium-sized follicles in assisted reproductive technology compromises the clinical pregnancy (CPR) and live birth (LBR) rates in IVF/ICSI cycles. METHODS: This retrospective cohort study reviewed 200 first IVF ± ICSI cycles out of a total of 340 cycles with complete data. Women underwent stimulation protocols with gonadotropins (Gn) and GnRH antagonist...
September 30, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28960429/the-effects-of-low-dose-human-chorionic-gonadotropin-combined-with-human-menopausal-gonadotropin-protocol-on-women-with-hypogonadotropic-hypogonadism-undergoing-ovarian-stimulation-for-in-vitro-fertilization
#20
Shutian Jiang, Yanping Kuang
OBJECTIVES: To investigate the effects of low-dose human chorionic gonadotropin (hCG) combined with human menopausal gonadotropin (HMG) protocol on cycle characteristics and outcomes of infertile women with hypogonadotropic hypogonadism (HH) undergoing ovarian stimulation for in vitro fertilization (IVF). DESIGN: A retrospective cohort study. SETTING: Tertiary-care academic medical centre. PATIENT(S): Forty-six infertile patients with HH and seventy-one infertile patients with tubal factor (TF) infertility undergoing IVF...
January 2018: Clinical Endocrinology
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