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https://www.readbyqxmd.com/read/29778369/programming-the-endometrium-for-deferred-transfer-of-cryopreserved-embryos-hormone-replacement-versus-modified-natural-cycles
#1
REVIEW
Eva R Groenewoud, Bernard J Cohlen, Nicholas S Macklon
Over the last decade the use of frozen-thawed embryo transfer has substantially increased, and currently up to one in two embryos transferred has been cryopreserved. To support implantation, endometrial and embryo maturity are required to be synchronized. This can be achieved in various ways. The most commonly applied endometrial preparation methods are the "natural cycle," in which the sequential estrogen and P necessary for endometrial maturation are derived from the developing follicle, and the "artificial" cycle, in which these are sequentially administered...
May 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29778367/role-of-gonadotropin-releasing-hormone-agonists-human-chorionic-gonadotropin-hcg-progesterone-and-estrogen-in-luteal-phase-support-after-hcg-triggering-and-when-in-pregnancy-hormonal-support-can-be-stopped
#2
REVIEW
Dominique de Ziegler, Paul Pirtea, Claus Yding Andersen, Jean Marc Ayoubi
Luteal phase support is mandatory in ovarian stimulation cycles in assisted reproductive technology owing to a deficit in LH pulsatility after the effects of exogenous hCG-used for triggering ovulation-vanish. This is classically accomplished by means of exogenous P administration, but emerging new options include microdoses of hCG and exogenous GnRH agonist. Although luteal phase support is commonly continued for up to 10 weeks into pregnancy, there is accumulating evidence that it can be stopped after the first ultrasound or even after a positive pregnancy test...
May 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29778366/introduction-management-of-the-luteal-phase-in-assisted-reproductive-technology
#3
Georg Griesinger, David Meldrum
The increasing utilization of a gonadotropin-releasing hormone agonist ovulation trigger and the widespread use of artificial cycles for the transfer of frozen-thawed or donated embryos has renewed interest in the luteal phase in assisted reproductive technology. The "luteal phase defect" phenomenon is now understood as a continuum: there is less impairment with milder stimulation than with more intense ovarian stimulation, and less impairment after controlled ovarian stimulation and human chorionic gonadotropin ovulation triggering than after gonadotropin-releasing hormone agonist ovulation triggering, the latter being associated with rapid luteolysis...
May 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29738181/-repeated-superovulation-induction-after-failure-in-previous-ivf-et-cycles-with-the-ultra-long-protocol-analysis-of-outcomes-of-clinical-pregnancy
#4
Bin Wang, Na Kong, Jing-Yu Liu, Ning-Yuan Zhang, Ying-Chun Zhu, Jian-Jun Zhou
Objective: To analyze the clinical outcomes of repeated superovulation induction in patients with adenomyosis or moderate to severe pelvic endometriosis after failure in previous IVF-ET cycles with the ultra-long protocol. METHODS: We retrospectively analyzed the clinical data about 37 patients with adenomyosis or moderate to severe pelvic endometriosis in our center from 2009 to 2013, who underwent repeated IVF-ET after failure in the previous cycles with the ultra-long protocol, namely by injection of 2-6 ampoules of 3...
December 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/29717220/conserved-and-novel-responses-to-cytokinin-treatments-during-flower-and-fruit-development-in-brassica-napus-and-arabidopsis-thaliana
#5
Victor M Zuñiga-Mayo, Cesar R Baños-Bayardo, David Díaz-Ramírez, Nayelli Marsch-Martínez, Stefan de Folter
Hormones are an important component in the regulatory networks guiding plant development. Cytokinins are involved in different physiological and developmental processes in plants. In the model plant Arabidopsis thaliana, cytokinin application during gynoecium development produces conspicuous phenotypes. On the other hand, Brassica napus, also known as canola, is a crop plant belonging to the Brassicaceae family, as A. thaliana. This makes B. napus a good candidate to study whether the cytokinin responses observed in A...
May 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29681713/does-pretrigger-echogenic-endometrium-in-assisted-reproductive-technology-cycles-reflect-raised-serum-progesterone-level
#6
Monna Pandurangi, N Sanjeeva Reddy, G Usha Rani, Hepzibha Kirubamani
Background: Serum progesterone is the main hormone of the luteal phase. The hyperechoic pattern of the endometrium in the luteal phase is believed to be induced by raised serum progesterone. Serum progesterone is found to be raised cases of controlled ovarian stimulation (COS) cycle on the day of ovulation trigger. Aim: This study aims to find the association between echogenicity of endometrium and raised serum progesterone. Objective: The objective of this study is to determine whether raised pretrigger serum progesterone influences the echogenicity of the endometrium...
January 2018: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/29680904/abnormal-development-of-floral-meristem-triggers-defective-morphogenesis-of-generative-system-in-transgenic-tomatoes
#7
Inna Chaban, Marat Khaliluev, Ekaterina Baranova, Neonila Kononenko, Sergey Dolgov, Elena Smirnova
Parthenocarpy and fruit malformations are common among independent transgenic tomato lines, expressing genes encoding different pathogenesis-related (PR) protein and antimicrobal peptides. Abnormal phenotype developed independently of the expression and type of target genes, but distinctive features during flower and fruit development were detected in each transgenic line. We analyzed the morphology, anatomy, and cytoembryology of abnormal flowers and fruits from these transgenic tomato lines and compared them with flowers and fruits of wild tomatoes, line YaLF used for transformation, and transgenic plants with normal phenotype...
April 21, 2018: Protoplasma
https://www.readbyqxmd.com/read/29668885/follicle-capacitation-a-meta-analysis-to-investigate-the-transcriptome-dynamics-following-fsh-decline-in-bovine-granulosa-cells
#8
David A Landry, Marc-André Sirard
In recent years, exciting progress was made to improve the embryo outcome after ovarian stimulation in domestic animals. The practice of follicle-stimulating hormone (FSH) withdrawal, which is defined as the period of time between the last injection of FSH and oocyte retrieval, resulted in embryo yields significantly superior. Since then, specific changes in the transcriptome of granulosa cells were associated with the increase and also the decline in oocyte developmental competence following the FSH decline...
April 14, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29656071/-natural-cycle-for-frozen-thawed-embryo-transfer-spontaneous-ovulation-or-triggering-by-hcg
#9
S Huberlant, M Vaast, T Anahory, M L Tailland, N Rougier, N Ranisavljevic, S Hamamah
OBJECTIVE: To compare frozen-thawed embryo transfer (FET) outcomes in natural cycles according to ovulation induction: spontaneous versus recombinant human chorionic gonadotrophin (r-hCG) triggering. METHODS: This retrospective study included all patients monitored for natural cycle FET during one year. When serial monitoring were performed until spontaneous LH rise, patients were included in group A (n=38) whereas those receiving r-hCG for ovulation triggering formed group B (n=43)...
April 11, 2018: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29602523/endocrine-paracrine-and-autocrine-signaling-pathways-that-regulate-ovulation
#10
REVIEW
JoAnne S Richards, Mario Ascoli
The central role of luteinizing hormone (LH) and its receptor (LHCGR) in triggering ovulation has been recognized for decades. Because the LHCGR is present in the mural (outermost) granulosa cell layer of preovulatory follicles (POFs), the LH-initiated signal has to be transmitted to another somatic cell type (cumulus granulosa cells) and the oocyte to release a fertilizable oocyte. Recent studies have shown that activation of the LHCGR initiates vectorial transfer of information among the two somatic cell types and the oocyte and the molecules and signaling pathways involved are now better understood...
March 27, 2018: Trends in Endocrinology and Metabolism: TEM
https://www.readbyqxmd.com/read/29572693/human-chorionic-gonadotropin-serum-levels-following-ovulation-triggering-and-ivf-cycle-outcome
#11
Yossi Mizrachi, Eran Horowitz, Jacob Farhi, David Levran, Arieh Raziel, Ariel Weissman
PURPOSE: The clinical significance of serum hCG levels after ovulation triggering was studied previously with conflicting results. Our aim was to study the correlation of hCG levels on the day after ovulation triggering using recombinant hCG (r-hCG) with treatment outcome. METHODS: A prospective observational study of all fresh IVF/ICSI cycles in a single medical center, between January 2015 and June 2016, was performed. hCG serum levels were obtained 10-12 h following ovulation triggering with 250 mcg r-hCG...
March 23, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29564316/human-chorionic-gonadotropin-administered-natural-cycle-versus-spontaneous-ovulatory-cycle-in-patients-undergoing-two-pronuclear-zygote-frozen-thawed-embryo-transfer
#12
You-Jung Lee, Chung-Hoon Kim, Do-Young Kim, Jun-Woo Ahn, Sung-Hoon Kim, Hee-Dong Chae, Byung-Moon Kang
Objective: To compare human chorionic gonadotropin (HCG)-administered natural cycle with spontaneous ovulatory cycle in patients undergoing frozen-thawed embryo transfer (FTET) in natural cycles. Methods: In this retrospective cohort study, we analyzed the clinical outcome of a total of 166 consecutive FTET cycles that were performed in either natural cycle controlled by HCG for ovulation triggering (HCG group, n=110) or natural cycle with spontaneous ovulation (control group, n=56) in 166 infertile patients between January 2009 and November 2013...
March 2018: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/29548330/with-low-ovarian-reserve-highly-individualized-egg-retrieval-hier-improves-ivf-results-by-avoiding-premature-luteinization
#13
Yan-Guang Wu, David H Barad, Vitaly A Kushnir, Qi Wang, Lin Zhang, Sarah K Darmon, David F Albertini, Norbert Gleicher
BACKGROUND: Highly Individualized Egg Retrieval (HIER), defined as age-specific early oocyte retrieval (ER), has been demonstrated to avoid premature luteinization in women ≥43. We here investigated whether HIER also applies to younger women with premature ovarian aging (POA), and what best lead follicle size should be for administration of ovulation-triggers. METHODS: Fifty-six women ≥43, and 37 POA patients underwent IVF cycles. Granulosa cells (GCs) were isolated, cultures were established, RNA was extracted and real-time PCR analyses performed, with gene expressions at mRNA level investigated for FSH receptor (FSHR), luteinizing hormone receptor (LHCPR), P450 aromatase (CYP19a1) and progesterone receptor (PGR)...
March 16, 2018: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29544639/the-ovarian-hyperstimulation-syndrome
#14
Zeev Blumenfeld
The ovarian hyperstimulation syndrome (OHSS) is an iatrogenic syndrome, which may, infrequently, become severe and evenly fatal. Until the last decade, the worldwide popularity of assisted reproductive technology (ART) and ovulation induction/controlled ovarian hyperstimulation employed in ART for either in vivo fertilization or in vitro fertilization, in the last two decades, has been accompanied by an increase in the cases of OHSS. In the last decade, the substitution of the human chorionic gonadotropin trigger with the gonadotropin-releasing hormone agonist trigger has decreased the incidence of this syndrome but did not eliminate it completely...
2018: Vitamins and Hormones
https://www.readbyqxmd.com/read/29526587/parasitoids-turn-herbivores-into-mutualists-in-a-nursery-system-involving-active-pollination
#15
Carlos Eduardo Pereira Nunes, Pietro Kiyoshi Maruyama, Marianne Azevedo-Silva, Marlies Sazima
Nursery pollination involves pollinators that lay eggs on the flowers they pollinate and have their brood fed on flower parts or developing ovules [1-4]. Active pollination, a ritualistic behavioral sequence shown by nursery pollinators when transferring pollen from anthers to stigmas, is known in only four plant lineages [5-8], including the classical examples of fig trees-fig wasps and yuccas-yucca moths [5, 6]. We report in detail a system in which weevils actively pollinate orchids prior to having their larvae fed on the developing fruits...
March 19, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29523204/individualized-controlled-ovarian-stimulation-in-expected-poor-responders-an-update
#16
REVIEW
Thor Haahr, Sandro C Esteves, Peter Humaidan
Controlled ovarian stimulation with subsequent multi-follicular development continues to be a keystone in ART. Evidence supports an individualized approach to ovarian stimulation, usually involving combinations of ovarian reserve tests, body mass index and age to tailor the exogenous gonadotropin dose, and potentially adjuvant treatment aiming for high safety and a shortening of time to live birth. While stimulation and trigger concepts have been developed successfully in normo- and hyperresponder patients, the poor responder patient remains difficult to manage...
March 9, 2018: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/29481670/impact-of-late-follicular-phase-elevated-serum-progesterone-on-cumulative-live-birth-rates-is-there-a-deleterious-effect-on-embryo-quality
#17
A Racca, S Santos-Ribeiro, N De Munck, S Mackens, P Drakopoulos, M Camus, G Verheyen, H Tournaye, C Blockeel
STUDY QUESTION: Is elevated late-follicular phase progesterone (EP) associated with a deleterious impact on embryo quality (EQ) and cumulative live birth rates (LBRs)? SUMMARY ANSWER: EP was associated with a decrease in embryo utilization and cumulative LBRs. WHAT IS KNOWN ALREADY: Ovarian stimulation promotes the production of progesterone (P) which adversely affects IVF pregnancy outcomes. However, evidence regarding a potential association between EP an EQ is lacking...
May 1, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29453138/increased-coagulation-index-as-measured-by-thromboelastography-during-ovarian-stimulation-for-in-vitro-fertilization-influence-of-the-final-oocyte-maturation-triggering-agent
#18
Ronit Beck-Fruchter, Israel Gavish, Shira Baram, Yoel Geslevich, Amir Weiss
OBJECTIVE: Thromboelastography (TEG) is a viscoelastic test of hemostasis which allows measurement of the processes of clot initiation, propagation, stabilization, and dissolution in real time. In this study we aimed to evaluate the alterations in coagulation as measured by TEG during In Vitro Fertilization (IVF) stimulation cycles and to investigate whether final oocyte maturation with recombinant hCG (rhCG) versus GnRH agonist results in a different coagulation state. STUDY DESIGN: This is a prospective observational study which included fifty-three normogonadotrophic women...
April 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29438491/new-insights-on-a-ngf-mediated-pathway-to-induce-ovulation-in-rabbits-oryctolagus-cuniculus
#19
Margherita Maranesi, Linda Petrucci, Leonardo Leonardi, Federica Piro, Pilar García Rebollar, Pilar Millán, Paolo Cocci, Cecilia Vullo, Francesco Parillo, Arlindo Moura, Gabriela Gonzalez Mariscal, Cristiano Boiti, Massimo Zerani
To investigate the ovulatory mechanisms triggered by raw semen (RS) in rabbits, we examined the expression of nerve growth factor (NGF)-a supposed ovulation-inducing factor (OIF)-and cognate receptors in anterior pituitary, ovary, and cervix as well as plasma NGF and luteinizing hormone (LH) concentrations. Six does/group were sham-inseminated with sterile saline (PBS), naturally mated (NM), inseminated with RS alone or after lumbar anesthesia (ARS), or treatment with COX inhibitors (CIRS). Immunohistochemistry revealed positive signals for NGF and receptors in all tissues...
May 1, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29430153/the-impact-of-progesterone-level-on-day-of-hcg-injection-in-ivf-cycles-on-clinical-pregnancy-rate
#20
Jawa Ashmita, Swarankar Vikas, Garg Swati
Background: Premature progesterone rise (PPR) has long been implicated as contributing to implantation failure. Despite the use of gonadotropin-releasing hormone (GnRH) analogues, subtle increases in serum progesterone ( P 4 ) levels beyond a threshold progesterone concentration were observed on the day of trigger in controlled ovarian hyperstimulation cycles. Aims: The purpose of the study was to evaluate the incidence of PPR on the day of trigger in conventional IVF/ICSI cycles and its impact on clinical pregnancy rate...
October 2017: Journal of Human Reproductive Sciences
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