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https://www.readbyqxmd.com/read/27865446/the-use-of-utrogestan-during-controlled-ovarian-hyperstimulation-in-normally-ovulating-women-undergoing-in%C3%A2-vitro-fertilization-or-intracytoplasmic-sperm-injection-treatments-in-combination-with-a-freeze-all-strategy-a-randomized-controlled-dose-finding-study
#1
Xiuxian Zhu, Hongjuan Ye, Yonglun Fu
OBJECTIVE: To compare the clinical characteristics in a Utrogestan and hMG protocol with the use of different doses of Utrogestan in normally ovulating women undergoing in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatments. DESIGN: Prospective controlled study. SETTING: Tertiary-care academic medical center. PATIENT(S): A total of 150 infertile patients undergoing IVF/ICSI treatments. INTERVENTION(S): Utrogestan and hMG were administered simultaneously beginning on cycle day 3...
November 16, 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27809622/nitric-oxide-donors-increase-the-pregnancy-rate-in-patients-with-unexplained-infertility-undergoing-clomiphene-citrate-stimulation-and-intrauterine-insemination-a-randomized-controlled-pilot-study
#2
Mohamed Abdel Razik, Seham El-Berry, Ahmed El-Nezamy, Ahmed Saad, Ahmed Abdel Wahab
This study evaluated the effects of nitric oxide donor's treatment on the pregnancy rate and uterine blood flow in patients with unexplained infertility undergoing clomiphene citrate stimulation and intrauterine insemination. A total of 120 patients were randomly allocated to a control group who received 100 mg clomiphene citrate daily from day 5 to 9 of cycle plus placebo vaginal tablets, and a study group received clomiphene citrate plus isosorbide mononitrate 10 mg vaginal tablets. Vaginal ultrasound was done before treatment and every other day starting from day 12 of cycle to count mature follicles and ovulation was triggered by IM injection of 10 000 IU hCG when one follicle measured 18 ≥ mm followed by intrauterine insemination after 36 h...
November 4, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27806429/cellular-localization-of-relaxin-like-gonad-stimulating-peptide-expression-in-asterias-rubens-new-insights-into-neurohormonal-control-of-spawning-in-starfish
#3
Ming Lin, Masatoshi Mita, Michaela Egertová, Cleidiane G Zampronio, Alexandra M Jones, Maurice R Elphick
Gamete maturation and spawning in starfish is triggered by a gonad-stimulating substance (GSS), which is present in extracts of the radial nerve cords. Purification of GSS from the starfish Patiria pectinifera identified GSS as a relaxin-like polypeptide, which is now known as relaxin-like gonad-stimulating peptide (RGP). Cells expressing RGP in the radial nerve cord of P. pectinifera have been visualized, but the presence of RGP-expressing cells in other parts of the starfish body has not been investigated...
November 2, 2016: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/27798046/frozen-thawed-embryo-transfers-in-natural-cycles-with-spontaneous-or-induced-ovulation-the-search-for-the-best-protocol-continues
#4
M Montagut, S Santos-Ribeiro, M De Vos, N P Polyzos, P Drakopoulos, S Mackens, A van de Vijver, L van Landuyt, G Verheyen, H Tournaye, C Blockeel
STUDY QUESTION: Is natural cycle frozen-thawed embryo transfer (NC-FET) associated with better clinical pregnancy rates (CPR) when compared to modified natural cycle frozen-thawed embryo transfer (mNC-FET)? SUMMARY ANSWER: NC-FET is associated with a higher CPR compared to mNC-FET. WHAT IS KNOWN ALREADY: There is conflicting evidence regarding the impact of hCG triggering on clinical outcomes after frozen-thawed embryo transfer (FET), and information on the effect of luteal phase support (LPS) is lacking...
October 25, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27774052/altered-expression-of-genes-encoding-neurotransmitter-receptors-in-gnrh-neurons-of-proestrous-mice
#5
Csaba Vastagh, Annie Rodolosse, Norbert Solymosi, Zsolt Liposits
Gonadotropin-releasing hormone (GnRH) neurons play a key role in the central regulation of reproduction. In proestrous female mice, estradiol triggers the pre-ovulatory GnRH surge, however, its impact on the expression of neurotransmitter receptor genes in GnRH neurons has not been explored yet. We hypothesized that proestrus is accompanied by substantial changes in the expression profile of genes coding for neurotransmitter receptors in GnRH neurons. We compared the transcriptome of GnRH neurons obtained from intact, proestrous, and metestrous female GnRH-GFP transgenic mice, respectively...
2016: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/27770611/creb-activity-is-required-for-luteinizing-hormone-induced-the-expression-of-egf-like-factors
#6
Yakun Wang, Xiaoqiong Hao, Jing Yang, Jia Li, Meijia Zhang
A surge of luteinizing hormone (LH) from the pituitary gland induces the expression of the epidermal growth factor (EGF)-like factors, which triggers oocyte maturation, cumulus expansion, and ovulation. How LH induces EGF-like factor expression is unclear. In the present study, a rapid increase of phosphorylated cAMP response element binding protein (CREB) was observed after the activation of LH receptor by human chorionic gonadotropin. Large antral follicles from equine chorionic gonadotropin-primed mice were cultured in medium with LH to stimulate the expression of EGF-like factors...
October 22, 2016: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/27738657/gnrh-agonist-trigger-versus-hcg-trigger-in-gnrh-antagonist-in-ivf-icsi-cycles-a-review-article
#7
Ashraf Alyasin, Shayesteh Mehdinejadiani, Marzieh Ghasemi
Routinely, a bolus of 5.000-10.000 IU human chorionic gonadotropin (hCG) is used for the final follicular maturation and ovulation as a standard method. HCG has the same effect of luteinizing hormone (LH) with long half-life. It has the long lutheotrophic effect which increases the risk of ovarian hyper stimulation syndrome (OHSS). Recently, gonadotropin-releasing hormone agonist (GnRH-a) trigger has been used for the induction of final follicular maturation and ovulation with the aim of reducing the OHSS risk...
September 2016: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/27738654/pregnancy-predictors-after-intrauterine-insemination-in-cases-of-unexplained-infertility-a-prospective-study
#8
Ishita Ganguly, Aparna Singh, Shilpa Bhandari, Pallavi Agrawal, Nitika Gupta
Introduction. Aim of the study was to find the effect of various prognostic factors in cases of unexplained infertility undergoing controlled ovarian stimulation (COS) with intrauterine insemination (IUI). Methods. 146 cases of unexplained infertility were included. A maximum of 3 cycles of IUI were done with clomiphene citrate/HMG. Ovulation trigger was given when the largest follicle diameter was >18 mm, and IUI was planned 36 hours later. Luteal phase support was given for 15 days, urine pregnancy test was done on day 15, ultrasonography was done at 7 weeks, and pregnancy was followed up till delivery...
2016: International Journal of Reproductive Medicine
https://www.readbyqxmd.com/read/27733489/recombinant-fetuin-b-protein-maintains-high-fertilization-rate-in-cumulus-cell-free-mouse-oocytes
#9
E Dietzel, J Floehr, E Van de Leur, R Weiskirchen, W Jahnen-Dechent
STUDY QUESTION: Does fetuin-B inhibit premature zona pellucida (ZP) hardening in mouse oocytes in vitro and thus increase IVF rate? SUMMARY ANSWER: Supplementation of oocyte in vitro maturation (IVM) media with recombinant mouse fetuin-B (rmFetuB) increased fertilization rate without affecting mouse embryo development into blastocysts. WHAT IS KNOWN ALREADY: Mice deficient in fetuin-B are infertile owing to premature ZP hardening. Premature ZP hardening also occurs during oocyte IVM leading to decreased fertilization rate...
October 12, 2016: Molecular Human Reproduction
https://www.readbyqxmd.com/read/27702990/dying-to-live-cell-elimination-as-a-developmental-strategy-in-angiosperm-seeds
#10
Gwyneth C Ingram
The complete elimination of unwanted cells during development is a repeated theme in both multicellular animals and in plants. In plants, such events have been extensively studied and reviewed in terms of their molecular regulation, of marker genes and proteins expressed, and in terms of cellular changes associated with their progression. This review will take a slightly different view of developmental cell elimination and will concentrate specifically on the numerous elimination events that occur during ovule and seed development (here grouped together as seed development)...
October 4, 2016: Journal of Experimental Botany
https://www.readbyqxmd.com/read/27686502/does-intrauterine-insemination-timing-matter-for-achieving-pregnancy-during-ovulation-induction-using-gonadotropins-a-retrospective-cohort-study
#11
Omer Hamid Yumusak, Serkan Kahyaoglu, Meryem Kuru Pekcan, Esra Isci, Mehmet Cinar, Yasemin Tasci
BACKGROUND: Intrauterine insemination (IUI) is a commonly used procedure to increase the infertile couples' chance of pregnancy. Single or double insemination and different timing choices are modifications of this intervention. The aim of this study was to elucidate the effect of the IUI procedure on clinical pregnancy rates when performed at 24 hours or 36 hours after ovulation triggered by human chorionic gonadotropin (hCG) following ovulation induction with gonadotropins. METHODS: One hundred and thirteen women diagnosed with polycystic ovarian syndrome (PCOS) (as per Rotterdam's criteria) or unexplained infertility, who were treated using gonadotropins for ovulation induction and IUI for increasing fertilization potential, were recruited from the medical records of the infertility clinic...
September 26, 2016: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/27685935/oocyte-cryopreservation-for-fertility-preservation-in-women-with-cancer
#12
Javier Domingo, Juan A Garcia-Velasco
PURPOSE OF REVIEW: It is necessary to clarify the fertility preservation-related points of concern that often frighten patients or physicians when it comes to deciding about oocyte cryopreservation for fertility preservation, which are often perceived as procedure limitations, are sometimes real and often theoretical and may make the prognosis worse. RECENT FINDINGS: Letrozole added to gonadotrophins for controlled ovarian stimulation is safe when applied to hormone-sensitive cancer patients as it avoids associated high estradiol levels...
December 2016: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/27668884/expression-analysis-of-fertilization-early-embryogenesis-associated-genes-in-phalaenopsis-orchids
#13
Jhun-Chen Chen, Miao-Ju Wei, Su-Chiung Fang
One of the distinct reproductive programs in orchid species is pollination-triggered ovule development and megasporogenesis. During sexual reproduction, fertilization occurs days to months after pollination. The molecular mechanisms evolved to carry out this strategic reproductive program remain unclear. In the August issue of Plant Physiology (1) , we report comprehensive studies of comparative genome-wide gene expression in various reproductive tissues and the molecular events associated with developmental transitions unique to sexual reproduction of Phalaenopsis aphrodite...
September 26, 2016: Plant Signaling & Behavior
https://www.readbyqxmd.com/read/27629906/appetitive-and-consummatory-sexual-behaviors-of-rams-treated-with-exogenous-testosterone-and-exposed-to-anestrus-dorper-ewes-efficacy-of-the-male-effect
#14
Luz M Tejada, Cesar A Meza-Herrera, Raymundo Rivas-Muñoz, Rafael Rodríguez-Martínez, Evaristo Carrillo, Miguel Mellado, Francisco G Véliz-Deras
We determine whether Dorper rams treated with testosterone in the sexual resting season trigger both appetitive and consummatory sexual behaviors and sexual and reproductive outcomes in anestrous ewes at 26° North during March-April. Dorper rams (n = 12, 2.5 years) were randomly divided prior to mating in two groups: GT (treated group; n = 6), treated with testosterone propionate (25 mg i.m. every 3 days × 3 weeks) and GC (control group; n = 6), treated with saline. Thereafter, adult anovulatory Dorper ewes (n = 61) were exposed to the GT-rams while the other group (n = 60) was exposed to the GC-rams...
September 14, 2016: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/27604758/follicular-cysts-a-single-sign-and-different-diseases-a-view-from-comparative-medicine
#15
Hugo H Ortega, Pablo U Díaz, Natalia R Salvetti, Gustavo J Hein, Belkis E Marelli, Fernanda M Rodríguez, Antonela F Stassi, Florencia Rey
Ovarian cystic follicles are the sign of important causes of reproductive failure in numerous species. In this review, some morphological, endocrinological and clinical aspects of cystic follicles in women, cows, mares, sows and bitches are discussed. Follicular cysts are the consequence of the failure of a mature follicle to ovulate at the appointed time of ovulation in the estrous cycle. Although the etiology of follicular cysts remains unknown, this review examines the evidence about the role of endocrine signaling systems in the specific disease or syndrome in each of the species mentioned above...
2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27589375/mouse-oocytes-acquire-mechanisms-that-permit-independent-cell-volume-regulation-at-the-end-of-oogenesis
#16
Samantha Richard, Alina P Tartia, Detlev Boison, Jay M Baltz
Mouse embryos employ a unique mechanism of cell volume regulation in which glycine is imported via the GLYT1 transporter to regulate intracellular osmotic pressure. Independent cell volume regulation normally becomes active in the oocyte after ovulation is triggered. This involves two steps: the first is the release of the strong adhesion between the oocyte and zona pellucida (ZP) while the second is the activation of GLYT1. In fully-grown oocytes, release of adhesion and GLYT1 activation also occur spontaneously in oocytes removed from the follicle...
September 2, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27560548/evolution-of-the-hypothalamic-pituitary-gonadal-axis-regulation-in-vertebrates-revealed-by-knockout-medaka
#17
Akiko Takahashi, Shinji Kanda, Tomohiro Abe, Yoshitaka Oka
Reproduction is essential for life, but its regulatory mechanism is diverse. The analysis of this diversity should lead us to understand the evolutionary process of the regulation of reproduction. In mammals, the hypothalamic-pituitary-gonadal axis plays an essential role in such regulation, and each component, hypothalamic GnRH, and pituitary gonadotropins, LH, and FSH, is indispensable. However, the common principle of the hypothalamic-pituitary-gonadal axis regulation among vertebrates remains unclear. Here, we used a teleost medaka, which is phylogenetically distant from mammals, and analyzed phenotypes of gene knockouts (KOs) for GnRH, LH, and FSH...
October 2016: Endocrinology
https://www.readbyqxmd.com/read/27547681/which-is-the-best-intrauterine-insemination-timing-choice-following-exogenous-hcg-administration-during-ovulation-induction-by-using-clomiphene-citrate-treatment-a-retrospective-study
#18
Omer Hamid Yumusak, Serkan Kahyaoglu, Meryem Kuru Pekcan, Esra Isci, Şebnem Ozyer, Mahmut Nedim Cicek, Yasemin Tasci, Salim Erkaya
OBJECTIVE: To evaluate the impact of intrauterine insemination timing performed 24 or 36 h later following ovulation trigger on clinical pregnancy rate during ovulation induction with clomiphene citrate among infertile women was the objective of this study. METHODS: The medical records of 280 infertile patients who have underwent ovulation induction by using clomiphene citrate have been evaluated and cycle outcomes of the patients have been investigated specifically based on the timing of intrauterine insemination during the treatment cycle...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27482380/perimenstrual-asthma-from-pathophysiology-to-treatment-strategies
#19
REVIEW
Alessandra Graziottin, Audrey Serafini
The prevalence of asthma is about 9,7 % in women and 5,5 % in men. Asthma can deteriorate during the perimenstrual period, a phenomenon known as perimenstrual asthma (PMA), which represents a unique, highly symptomatic asthma phenotype. It is distinguished from traditional allergic asthma by aspirin sensitivity, less atopy, and lower lung capacity. PMA incidence is reported to vary between 19 and 40 % of asthmatic women. The presence of PMA has been related to increases in asthma-related emergency department visits, hospitalizations and emergency treatment including intubations...
2016: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/27468638/ultrastructural-immunogold-localization-of-major-sperm-protein-msp-in-spermatogenic-cells-of-the-nematode-acrobeles-complexus-nematoda-rhabditida
#20
Vladimir V Yushin, Myriam Claeys, Wim Bert
The nematode spermatozoa represent a highly modified (aberrant) type of male gametes that lack a flagellum but for which the process of spermatogenesis culminates in the production of a crawling spermatozoon on the basis of the cytoskeletal component known as "major sperm protein", or MSP. MSP is also known as an important hormone triggering oocyte maturation and ovulation in the model nematode Caenorhabditis elegans, where this protein was first identified. However, direct evidence of MSP localization and of its fate in nematode spermatogenic cells is rare...
October 2016: Micron: the International Research and Review Journal for Microscopy
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