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William F Kendall, Emmanuel C Opara
Application of microencapsulation to the immunoisolation of pancreatic islets holds promise for expanding the use of islet transplantation as a treatment option for Type 1 diabetes. It is generally believed that successful development of a reliable methodology will ideally allow for transplantation of pancreatic islets that are protected from the immune system, thereby obviating the need for the use of immunosuppressive drugs and their attendant side effects. In addition, this technology has the potential to expand the donor pool as islets from nonhuman donors could be used as xenografts in human patients...
2017: Methods in Molecular Biology
Hongtao Liu, Nanping Wang, Xingming Chu, Ting Li, Ling Zheng, Shouliang Yan, Shijun Li
In order to identify radon-prone areas and evaluate radon risk level, a soil gas radon survey combined with gamma-ray spectrometry measurements was carried out in Shenzhen City, south China. Meanwhile, the statistical analysis was applied to evaluate the distribution of measured results. This paper presents the methodology of the radon risk assessment. A radon risk map was accomplished based on a combination of soil gas radon concentration (RC), soil air permeability (Perm.) and uranium ((238)U) concentration...
2016: Journal of Radioanalytical and Nuclear Chemistry
Hongying Fan, Qisha Zhu, Guorong Ma, Chanchan Shen, Bingren Zhang, Wei Wang
BACKGROUND: Cultural and personality factors might contribute to the clinical differences of psychiatric patients all over the world including China. One cultural oriented Chinese Adjective Descriptors of Personality (CADP) designed to measure normal personality traits, might be specifically associated with different personality disorder functioning styles. METHODS: We therefore have invited 201 healthy volunteers and 67 personality disorder patients to undergo CADP, the Parker Personality Measure (PERM), and the Plutchik-van Praag Depression Inventory (PVP) tests...
2016: BMC Psychiatry
Hui Zhao, Qi-Song Liu, Hao Geng, Yuan Tian, Min Cheng, Yan-Hong Jiang, Ming-Sheng Xie, Xiao-Gang Niu, Fan Jiang, Ya-Ou Zhang, Yuan-Zhi Lao, Yun-Dong Wu, Nai-Han Xu, Zi-Gang Li
Described is a facile helix-nucleating template based on a tethered aspartic acid at the N-terminus [terminal aspartic acid (TD)]. The nucleating effect of the template is subtly influenced by the substituent at the end of the side-chain-end tether as indicated by circular dichroism, nuclear magnetic resonance, and molecular dynamics simulations. Unlike most nucleating strategies, the N-terminal amine is preserved, thus enabling further modification. Peptidomimetic estrogen receptor modulators (PERMs) constructed using this strategy show improved therapeutic properties...
September 19, 2016: Angewandte Chemie
Peter Sasieni, Adam R Brentnall
Cancer survival comparisons between cohorts are often assessed by estimates of relative or net survival. These measure the difference in mortality between those diagnosed with the disease and the general population. For such comparisons methods are needed to standardize cohort structure (including age at diagnosis) and all-cause mortality rates in the general population. Standardized non-parametric relative survival measures are evaluated by determining how well they (i) ensure the correct rank ordering, (ii) allow for differences in covariate distributions, and (iii) possess robustness and maximal estimation precision...
August 23, 2016: Biometrics
Abderrahim Oussalah, Patrice Hodonou Avogbe, Erwan Guyot, Céline Chery, Rosa-Maria Guéant-Rodriguez, Nathalie Ganne-Carrié, Aurélie Cobat, Darius Moradpour, Bertrand Nalpas, Francesco Negro, Thierry Poynard, Stanislas Pol, Pierre-Yves Bochud, Laurent Abel, Hélène Jeulin, Evelyne Schvoerer, Nicodème Chabi, Emile Amouzou, Ambaliou Sanni, Hélène Barraud, Pierre Rouyer, Thomas Josse, Laetitia Goffinet, Jean-Louis Jouve, Anne Minello, Claire Bonithon-Kopp, Gérard Thiefin, Vincent Di Martino, Michel Doffoël, Carine Richou, Jean-Jacques Raab, Patrick Hillon, Jean-Pierre Bronowicki, Jean-Louis Guéant, For The CiRCE Study Group
The molecular mechanisms of hepatocellular carcinoma (HCC) carcinogenesis are still not fully understood. DNA repair defects may influence HCC risk. The aim of the study was to look for potential genetic variants of DNA repair genes associated with HCC risk among patients with alcohol- or viral-induced liver disease. We performed four case-control studies on 2,006 European- (Derivation#1 and #2 studies) and African-ancestry (Validation#1 and #2 studies) patients originating from several cohorts in order to assess the association between genetic variants on DNA repair genes and HCC risk using a custom array encompassing 94 genes...
August 17, 2016: Oncotarget
Luís Antunes, Denisa Mendonça, Maria José Bento, Bernard Rachet
BACKGROUND: Association between cancer survival and socioeconomic status has been reported in various countries but it has never been studied in Portugal. We aimed here to study the role of education and socioeconomic deprivation level on survival from colorectal cancer in the North Region of Portugal using a population-based cancer registry dataset. METHODS: We analysed a cohort of patients aged 15-84 years, diagnosed with a colorectal cancer in the North Region of Portugal between 2000 and 2002...
2016: BMC Cancer
Sho Komukai, Satoshi Hattori
Cancer population studies based on cancer registry databases are widely conducted to address various research questions. In general, cancer registry databases do not collect information on cause of death. The net survival rate is defined as the survival rate if a subject would not die for any causes other than cancer. This counterfactual concept is widely used for the analyses of cancer registry data. Perme, Stare, and Estève (2012) proposed a nonparametric estimator of the net survival rate under the assumption that the censoring time is independent of the survival time and covariates...
August 1, 2016: Biometrics
Ashish Pandey, Jigneshkumar P, Satyaprakash Tripathi, C Gopi Mohan
The voltage dependent N-type Ca(2+) channel (NCC) receptor was identified to have therapeutic potential for the treatment of neuropathic pain and stroke disease. The Ca(2+) ion transport through the transmembrane influx is mainly dependent on the closing, opening, or intermediate state gating mechanism of NCC. Harnessing this dynamic gating mechanism at the structural level is an important and challenging physiological phenomenon. The three dimensional (3D) structure of this membrane receptor is not yet experimentally determined to understand its mechanism of action...
September 2012: Molecular Informatics
Margien L Seinen, Geerten P van Nieuw Amerongen, Nanne K H de Boer, Chris J J Mulder, Jan van Bezu, Adriaan A van Bodegraven
BACKGROUND: Azathioprine and mercaptopurine (MP) are effective in treating patients with inflammatory bowel disease (IBD). Immunosuppressive effects of thiopurines involve T-cell apoptosis after inhibition of GTPase Ras-related C3 botulinum toxin substrate 1 (Rac1). This study aimed to assess whether expression and activity of Rac1 or phosphorylated ezrin-radixin-moesin (pERM) in patients with IBD could provide a useful biomarker for the pharmacodynamic thiopurine effect and might be related to clinical effectiveness...
October 2016: Therapeutic Drug Monitoring
Miguel A Maestro, Ferdinand Molnár, Antonio Mouriño, Carsten Carlberg
INTRODUCTION: Vitamin D3 activates via its hormonal form 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3), the transcription factor vitamin D receptor (VDR). VDR is expressed in most human tissues and has more than 1,000 target genes. Thus, 1α,25(OH)2D3 and its synthetic analogs have a broad physiological impact. The crystal structures of the VDR ligand-binding domain (LBD), and its various ligands, further the understanding of the receptor's molecular actions. AREAS COVERED: We discuss the most important novel VDR ligands and the further insight derived from new structural information on VDR...
July 25, 2016: Expert Opinion on Therapeutic Patents
Magnus Röding, Erich Schuster, Katarina Logg, Malin Lundman, Per Bergström, Charlotta Hanson, Tobias Gebäck, Niklas Lorén
We explore computational high-throughput screening as a design strategy for heterogeneous, isotropic fiber materials. Fluid permeability, a key property in the design of soft porous materials, is systematically studied using a multi-scale lattice Boltzmann framework. After characterizing microscopic permeability as a function of solid volume fraction in the microstructure, we perform high-throughput computational screening of in excess of 35 000 macrostructures consisting of a continuous bulk interrupted by spherical/elliptical domains with either lower or higher microscopic permeability (hence with two distinct microscopic solid volume fractions and therefore two distinct microscopic permeabilities) to assess which parameters determine macroscopic permeability for a fixed average solid volume fraction...
July 20, 2016: Soft Matter
F Ferri, E Zini, E Auriemma, M Castagnaro, L M Coppola, A Peano, V Martella, N Decaro, P Kuhnert, S Ferro
Splenitis is uncommonly reported in dogs. Herein, the authors describe its prevalence, clinical findings and outcomes, histologic patterns, and causes. Splenic samples of dogs diagnosed with splenitis between 2005 and 2013 were collected and stained with hematoxylin and eosin, Gram, green-Gram, Giemsa, periodic acid-Schiff, and Ziehl-Neelsen. Samples were processed for polymerase chain reaction (PCR) to detect bacteria, fungi, and protozoa (Leishmania infantum, Hepatozoon canis). Thirty-three of 660 splenic samples (5%) had splenitis...
June 23, 2016: Veterinary Pathology
Blinc Ales Blinc, Matija Kozak, Miso Sabovic, Mojca Bozic Mijovski, Mojca Stegnar, Pavel Poredos, Andrej Kravos, Breda Barbic-Zagar, Janez Stare, Maja Pohar Perme
BACKGROUND: Patients with peripheral arterial disease (PAD) are at very high risk for cardiovascular events. How do patients with PAD differ from age- and sex-matched controls in survival, major ischemic events and revascularization procedures when both groups were managed according to the European guidelines on cardiovascular disease prevention? METHODS: 742 patients with PAD and 713 age and sex-matched control subjects without PAD, both groups aged 65±9 years at inclusion, were managed for 5 years according to the European guidelines on cardiovascular disease prevention and evaluated yearly for occurrence of death, non-fatal major ischemic events and revascularization procedures (minor events)...
June 22, 2016: International Angiology: a Journal of the International Union of Angiology
A R Schekotova, S W Paducheva, V N Gryaznov, N N Kiseleva, T A Dorosh
The article presents the biography of one wonderful doctors, who have high human, civil and professional qualities, Fyodor Ch. Gral.
2016: Experimental & Clinical Gastroenterology
V A Neschislyaev, M G Stolbova, P A Mokin, E V Orlova, A E Ershov
The composition and technology of complex probiotic in hard gelatin capsules was developed in Perm Branch "Biomed" of "Microgen" State Company. The preparation contains three production strains: Lactobacillus plantarum 8P-A3, L. acidophilus K3W24 and Bifidobacterium bifidum 1. Laboratory and experimental (preclinical) study of the probiotic included investigation of the antagonistic activity, "acute" and "chronic" toxicity, the effect of the preparation on histology and hematology of laboratory animals. The result of these studies suggested of the probiotic had high inhibitory activity against pathogenic microflora when compared with probiotic monopreparations and had no toxic effects on laboratory animals...
2016: Experimental & Clinical Gastroenterology
A V Tuev, O V Khlynova
Perm City is the large industrial, scientific, educational and cultural center in Volga Federal District. Also it is one of the oldest and the most attractive Ural cities. Higher medical education on the West Ural was founded in 1916. The main stages of the development of Perm State Medical University are lightened in the article. Perm State Medical University is the peculiar school of experts of different medical specialties, scientific and educational personnel, specialists of the middle range of the health care system...
2016: Experimental & Clinical Gastroenterology
Shengjie Zhai, Hui Zhao
Concentration polarization can be induced by the unique ion-perm selectivity of small nanopores, leading to a salt concentration gradient across nanopores. This concentration gradient can create diffusio-osmosis and induce an electric field, affecting ionic currents on DNA that translocates through a nanopore. Here this influence is theoretically investigated by solving the continuum Poisson-Nernst-Planck model for different salt concentrations, DNA surface charge densities, and pore properties. By implementing the perturbation method, we can explicitly compute the contribution of concentration polarization to the ionic current...
May 2016: Physical Review. E
Gil Zalsman, Keith Hawton, Danuta Wasserman, Kees van Heeringen, Ella Arensman, Marco Sarchiapone, Vladimir Carli, Cyril Höschl, Ran Barzilay, Judit Balazs, György Purebl, Jean Pierre Kahn, Pilar Alejandra Sáiz, Cendrine Bursztein Lipsicas, Julio Bobes, Doina Cozman, Ulrich Hegerl, Joseph Zohar
BACKGROUND: Many countries are developing suicide prevention strategies for which up-to-date, high-quality evidence is required. We present updated evidence for the effectiveness of suicide prevention interventions since 2005. METHODS: We searched PubMed and the Cochrane Library using multiple terms related to suicide prevention for studies published between Jan 1, 2005, and Dec 31, 2014. We assessed seven interventions: public and physician education, media strategies, screening, restricting access to suicide means, treatments, and internet or hotline support...
July 2016: Lancet Psychiatry
Nina Vene, Alenka Mavri, Mirjam Gubenšek, Gregor Tratar, Tjaša Vižintin Cuderman, Maja Pohar Perme, Aleš Blinc
BACKGROUND AND AIM: Interruption of anticoagulant treatment with warfarin or non-vitamin K antagonist oral anticoagulants (NOAC) represents a vulnerable period with an increased risk of thromboembolic events. What is the incidence of thromboembolic events in real-life patients with non-valvular atrial fibrillation treated with NOAC who had a discontinuation or cessation of treatment in comparison to patients on continuous treatment? PATIENTS AND METHODS: Registry data from 866 patients with non-valvular atrial fibrillation, aged 74...
2016: PloS One
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