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https://www.readbyqxmd.com/read/28058639/selection-of-an-efficient-promoter-and-its-application-in-toyocamycin-production-improvement-in-streptomyces-diastatochromogenes-1628
#1
Xianhao Xu, Juan Wang, Andreas Bechthold, Zheng Ma, Xiaoping Yu
The selection of efficient promoter is usually very crucial for gene expression and metabolic engineering in Streptomycetes. In this study, the synthetic promoters SPL-57and SPL-21, and the engineered promoter kasOp(*)were selected and their activities were examined by using a reporter gene assay based on GUS. All selected promoters which have been reported to be stronger than promoter permE(*), which was used as control promoter. As host we were choosing S. diastatochromogenes 1628, the producer of toyocamycin (TM)...
February 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28049237/the-foxo1-gene-obesity-interaction-increases-the-risk-of-type-2-diabetes-mellitus-in-a-chinese-han-population
#2
Lilin Gong, Rong Li, Wei Ren, Zengchan Wang, Zhihong Wang, Maosheng Yang, Suhua Zhang
Here, we aimed to study the effect of the forkhead box O1-insulin receptor substrate 2 (FOXO1-IRS2) gene interaction and the FOXO1 and IRS2 genes-environment interaction for the risk of type 2 diabetes mellitus (T2DM) in a Chinese Han population. We genotyped 7 polymorphism sites of FOXO1 gene and IRS2 gene in 780 unrelated Chinese Han people (474 cases of T2DM, 306 cases of healthy control). The risk of T2DM in individuals with AA genotype for rs7986407 and CC genotype for rs4581585 in FOXO1 gene was 2.092 and 2...
February 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28005615/trends-in-net-survival-from-kidney-cancer-in-six-european-latin-countries-results-from-the-sudcan-population-based-study
#3
Lucia Mangone, Nadine Bossard, Rafael Marcos-Gragera, Annamaria Pezzarossi, Francesca Roncaglia, Paolo Giorgi Rossi
Kidney cancer is a frequent malignant disease. To date, there is no evidence on the effectiveness of early detection and, in most cases, surgery represents the only standard treatment. So far, there is no standardized therapy for localized and locally advanced renal tumors; however, the recent introduction of target therapy has significantly improved the prognosis of metastatic disease. Therefore, survival differences in Europe are deemed to involve differences in diagnostic and therapeutic approaches. The aim of the SUDCAN collaborative study was to compare the net survival from kidney cancer between six European Latin countries (Belgium, France, Italy, Portugal, Spain, and Switzerland) and provide trends in net survival and dynamics of excess mortality rates up to 5 years after diagnosis...
January 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28005614/trends-in-net-survival-from-prostate-cancer-in-six-european-latin-countries-results-from-the-sudcan-population-based-study
#4
Pascale Grosclaude, Laurent Roche, Rafael Fuentes-Raspall, Nerea Larrañaga
Cancer survival is a key measure of the effectiveness of a health-care system. European Latin countries have some differences in their health system; therefore, it is of interest to compare them in terms of survival from cancer. Prostate cancer data from six countries (Belgium, France, Italy, Portugal, Spain, and Switzerland) were extracted from the EUROCARE-5 database (end of follow-up: 1 January 2009). First, the net survival (NS) was studied over the 2000-2004 period using the Pohar-Perme estimator. For trend analyses, the study period was specific to each country...
January 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28005613/trends-in-net-survival-from-ovarian-cancer-in-six-european-latin-countries-results-from-the-sudcan-population-based-study
#5
María-Dolores Chirlaque, Zoé Uhry, Diego Salmerón, María-Isabel Sánchez-Zapata, Gian Franco Zannoni, Carmen Navarro
European Latin countries have some similarities in their health systems. It is thus interesting to look at their differences in cancer survival (here, ovarian cancer) through monitoring of specific indicators of quality care. The aim of this SUDCAN collaborative study was to compare the trends in 1 and 5-year net survival from ovarian cancer and the trends in the excess mortality rates between six European Latin countries (Belgium, France, Italy, Portugal, Spain and Switzerland). The data were extracted from the EUROCARE-5 database...
January 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28005612/trends-in-net-survival-from-corpus-uteri-cancer-in-six-european-latin-countries-results-from-the-sudcan-population-based-study
#6
Luís Antunes, Laurent Roche, Maria José Bento
Corpus uteri cancer is the most common gynaecological cancer in women in Europe, but presents a relatively good prognosis. There were two main objectives in this study: estimate differences between countries in age-standardized net survival (NS) at 1 and 5 years in 2000-2004 and evaluate time trends in NS and excess mortality rates in 1992-2004. Data on corpus uteri malignant tumours (International Classification of Diseases for Oncology, third ed.: C54) were extracted from the EUROCARE database for six European Latin countries: Belgium, France, Italy, Portugal, Spain and Switzerland...
January 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28005611/trends-in-net-survival-from-cervical-cancer-in-six-european-latin-countries-results-from-the-sudcan-population-based-study
#7
Annemie Haelens, Laurent Roche, Joana Bastos, Anne-Sophie Woronoff, Manuel Zorzi, Julie Francart
Cancer survival is a key measure of the effectiveness of a healthcare system. As differences in healthcare systems are present among European Latin countries, it is of interest to look specifically at their similarities and differences in terms of cancer survival. Incident cases were extracted from the EUROCARE-V database for France, Italy, Spain, Switzerland, Portugal, and Belgium. One and 5-year net survivals (NS) were calculated for the period 2000-2004 using the Pohar-Perme estimator. Trends in NS over the 1992-2004 period and changes in the pattern of cancer excess mortality rate until 5 years after diagnosis were examined using a multivariate excess mortality rate model...
January 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28005609/trends-in-net-survival-from-skin-malignant-melanoma-in-six-european-latin-countries-results-from-the-sudcan-population-based-study
#8
Jaume Galceran, Zoé Uhry, Rafael Marcos-Gragera, Joan Borràs
In Europe as a whole, survival from skin malignant melanoma (SMM) has increased constantly since the 1980s. The aim of the SUDCAN collaborative study was to compare the trends in the 5-year net survival from SMM and in related excess mortality rate between six European Latin countries (Belgium, France, Italy, Portugal, Spain, and Switzerland). The data were extracted from the EUROCARE-5 database (end of follow-up: 01 January 2009). First, the net survival was studied over the 2000-2004 period using the Pohar-Perme estimator...
January 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28005608/trends-in-net-survival-lung-cancer-in-six-european-latin-countries-results-from-the-sudcan-population-based-study
#9
Andrea Bordoni, Zoé Uhry, Luis Antunes
Survival is a key measure of the effectiveness of a healthcare system. European Latin countries have some similarities in their health systems; it is thus interesting to examine their differences in survival from cancer, here, lung cancer. The aim of the SUDCAN collaborative study was to compare the trends in the 1- and 5-year net survival from lung cancer and the trends in the excess mortality rates between six European Latin countries (Belgium, France, Italy, Portugal, Spain and Switzerland). The data were extracted from the EUROCARE-5 database...
January 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28005607/trends-in-net-survival-from-pancreatic-cancer-in-six-european-latin-countries-results-from-the-sudcan-population-based-study
#10
Anne-Marie Bouvier, Nadine Bossard, Marc Colonna, Adelaida Garcia-Velasco, Maria Carulla, Sylvain Manfredi
Pancreatic cancer represents a real clinical challenge. The aim of the SUDCAN collaborative study was to compare the net survival from pancreatic cancer between six European Latin countries (Belgium, France, Italy, Portugal, Spain and Switzerland) and provide trends in net survival and dynamics of excess mortality rates up to 5 years after diagnosis. The data were extracted from the EUROCARE-5 database. First, net survival was studied over the period 2000-2004 using the Pohar-Perme estimator. For trend analyses, the study period was specific to each country...
January 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28005606/trends-in-net-survival-from-liver-cancer-in-six-european-latin-countries-results-from-the-sudcan-population-based-study
#11
Stefano Ferretti, Nadine Bossard, Florence Binder-Fouchard, Jean Faivre, Andrea Bordoni, Patrizia Biavati, Antonio Frassoldati
Liver cancer represents a major clinical challenge. The aim of the SUDCAN collaborative study was to compare the net survival from liver cancer between six European Latin countries (Belgium, France, Italy, Portugal, Spain and Switzerland) and provide trends in net survival and dynamics of excess mortality rates (EMRs) up to 5 years after diagnosis. The data were extracted from the EUROCARE-5 database. First, net survival was studied over the period 2000-2004 using the Pohar-Perme estimator. For trend analyses, the study period was specific to each country...
January 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28005605/trends-in-net-survival-from-rectal-cancer-in-six-european-latin-countries-results-from-the-sudcan-population-based-study
#12
Côme Lepage, Nadine Bossard, Olivier Dejardin, Maria C Carmona-Garcia, Sylvain Manfredi, Jean Faivre
Rectal cancer is a common and serious disease. The aim of the SUDCAN collaborative study was to compare the net survival from rectal cancer between six European Latin countries (Belgium, France, Italy, Portugal, Spain, and Switzerland) and provide trends in net survival and dynamics of excess mortality rates up to 5 years after diagnosis. The data were extracted from the EUROCARE-5 database. First, net survival was studied over the period 2000-2004 using the Pohar-Perme estimator. For trend analyses, the study-period was specific to each country...
January 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28005604/trends-in-net-survival-from-colon-cancer-in-six-european-latin-countries-results-from-the-sudcan-population-based-study
#13
Jean Faivre, Nadine Bossard, Valérie Jooste
Colon cancer represents a major public health issue. The aim of the SUDCAN collaborative study was to compare the net survival from colon cancer between six European Latin countries (Belgium, France, Italy, Portugal, Spain, and Switzerland) and provide trends in net survival and dynamics of the excess mortality rates up to 5 years after diagnosis. The data were extracted from the EUROCARE-5 database. First, net survival was studied over the 2000-2004 period using the Pohar-Perme estimator. For trend analyses, the study period was specific to each country...
January 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28005603/trends-in-net-survival-from-stomach-cancer-in-six-european-latin-countries-results-from-the-sudcan-population-based-study
#14
Luísa Glória, Nadine Bossard, Anne-Marie Bouvier, Alexandra Mayer-da-Silva, Jean Faivre, Ana Miranda
Gastric cancers are a clinical challenge. The aim of the SUDCAN collaborative study was to compare the net survival from gastric cancer between six European Latin countries (Belgium, France, Italy, Portugal, Spain and Switzerland) and explore the trends in net survival and in the dynamics of the excess mortality rates (EMRs) up to 5 years after diagnosis. The data were extracted from the EUROCARE-5 database. First, net survival was studied over the period 2000-2004 using the Pohar-Perme estimator. For trend analyses, the study period was specific to each country...
January 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28005602/trends-in-net-survival-from-esophageal-cancer-in-six-european-latin-countries-results-from-the-sudcan-population-based-study
#15
Guy Launoy, Nadine Bossard, Clara Castro, Sylvain Manfredi
Esophageal cancer represents a major clinical challenge because of its poor prognosis. The aim of the SUDCAN collaborative study was to compare the net survival from esophageal cancer between six European Latin countries (Belgium, France, Italy, Portugal, Spain, and Switzerland) and report the trends in net survival and the dynamics of excess mortality rates (EMRs) up to 5 years after diagnosis. The data were extracted from the EUROCARE-5 database. First, net survival was studied over the period 2000-2004 using the Pohar-Perme estimator...
January 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28005601/trends-in-net-survival-from-head-and-neck-cancer-in-six-european-latin-countries-results-from-the-sudcan-population-based-study
#16
Anne-Valérie Guizard, Zoé Uhry, Dominique de Raucourt, Guido Mazzoleni, Maria-José Sánchez, Karine Ligier
The aim of the SUDCAN collaborative study was to compare the trends in 1- and 5-year net survival and the trends in the dynamics of the excess mortality rates in head and neck cancers between six European Latin countries (Belgium, France, Italy, Portugal, Spain and Switzerland). The data were extracted from the EUROCARE-5 database. First, the net survival was studied over the 2000-2004 period using the Pohar-Perme estimator. For trend analyses, the study period was specific to each country. The results are reported from 1992 to 2004 in France, Italy, Spain and Switzerland and from 2000 to 2004 in Belgium and Portugal...
January 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28005600/new-insights-into-survival-trend-analyses-in-cancer-population-based-studies-the-sudcan-methodology
#17
Zoé Uhry, Nadine Bossard, Laurent Remontet, Jean Iwaz, Laurent Roche
The main objective of the SUDCAN study was to compare, for 15 cancer sites, the trends in net survival and excess mortality rates from cancer 5 years after diagnosis between six European Latin countries (Belgium, France, Italy, Portugal, Spain and Switzerland). The data were extracted from the EUROCARE-5 database. The study period ranged from 6 (Portugal, 2000-2005) to 18 years (Switzerland, 1989-2007). Trend analyses were carried out separately for each country and cancer site; the number of cases ranged from 1500 to 104 000 cases...
January 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/27995351/short-term-and-long-term-survival-of-interval-breast-cancers-taking-into-account-prognostic-features
#18
Solenne Delacour-Billon, Anne Laure Mathieu-Wacquant, Mario Campone, Nathalie Auffret, Sophie Amossé, Corinne Allioux, Anne Cowppli-Bony, Florence Molinié
PURPOSE: The aim of this population-based study was to estimate short-term and long-term survival of interval breast cancers and to compare them to clinically detected cancers, taking into account prognostic features. METHODS: This study included all interval cancers and clinically detected cancers diagnosed in the Loire-Atlantique population-based cancer registry from 2000 to 2010 in women aged 50-76 years. We used the Pohar-Perme method to estimate 5- and 10 year net survival rates and a flexible parametric model to compare interval cancer and clinically detected cancer prognosis with and without adjustment for the main prognostic factors (age, stage, histological grade, and phenotype)...
January 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/27912732/analysing-population-based-cancer-survival-settling-the-controversies
#19
Maja Pohar Perme, Jacques Estève, Bernard Rachet
BACKGROUND: The relative survival field has seen a lot of development in the last decade, resulting in many different and even opposing suggestions on how to approach the analysis. METHODS: We carefully define and explain the differences between the various measures of survival (overall survival, crude mortality, net survival and relative survival ratio) and study their differences using colon and prostate cancer data extracted from the national population-based cancer registry of Slovenia as well as simulated data...
December 3, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27906789/radon-and-thoron-in-air-occupational-exposure-study-within-selected-wine-cellars-of-the-western-cape-south-africa-and-associated-annual-effective-doses
#20
R Botha, R T Newman, R Lindsay, P P Maleka
This is the first known study of exposure of Rn (radon) and secondarily Rn (thoron) in-air activity concentrations assessed within nine selected wine cellars in four wine districts of the Western Cape (South Africa) and the associated annual occupational effective doses. E-PERM electret ion chambers (EIC) and RAD-7 α-detectors were used to perform these measurements. The radon in-air levels ranged from 12 ± 4 Bq m to 770 ± 40 Bq m within the nine selected wine cellars. Eight of the nine wine cellars (excluding results from cellar w-6) had a median radon in-air activity concentration of 48 ± 8 Bq m...
January 2017: Health Physics
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