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https://www.readbyqxmd.com/read/29022078/survival-benefit-of-mantle-cell-lymphoma-patients-enrolled-in-clinical-trials-a-joint-study-from-the-lysa-group-and-french-cancer-registries
#1
Alix Augustin, Steven Le Gouill, Rémy Gressin, Aurélie Bertaut, Alain Monnereau, Anne-Sophie Woronoff, Brigitte Trétarre, Patricia Delafosse, Xavier Troussard, Anne Moreau, Olivier Hermine, Marc Maynadié
PURPOSE: Mantle cell lymphoma (MCL) is a rare non-Hodgkin's lymphoma entity with a poor prognosis. Therapeutic advances have improved the survival of patients enrolled in clinical trials; however, their impact on patients outside clinical trials remains unclear. In this work, we compared patient outcome inside and outside clinical trials. METHODS: We identified MCL patients recorded in six French population-based registries between 2008 and 2012 to perform a comparison with patients enrolled in two prospective multicenter MCL clinical trials conducted by the LYSA group during the same period...
October 11, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28968953/brip1-coding-variants-are-associated-with-a-high-risk-of-hepatocellular-carcinoma-occurrence-in-patients-with-hcv-or-hbv-related-liver-disease
#2
Abderrahim Oussalah, Patrice Hodonou Avogbe, Erwan Guyot, Céline Chery, Rosa-Maria Guéant-Rodriguez, Nathalie Ganne-Carrié, Aurélie Cobat, Darius Moradpour, Bertrand Nalpas, Francesco Negro, Thierry Poynard, Stanislas Pol, Pierre-Yves Bochud, Laurent Abel, Hélène Jeulin, Evelyne Schvoerer, Nicodème Chabi, Emile Amouzou, Ambaliou Sanni, Hélène Barraud, Pierre Rouyer, Thomas Josse, Laetitia Goffinet, Jean-Louis Jouve, Anne Minello, Claire Bonithon-Kopp, Gérard Thiefin, Vincent Di Martino, Michel Doffoël, Carine Richou, Jean-Jacques Raab, Patrick Hillon, Jean-Pierre Bronowicki, Jean-Louis Guéant
The molecular mechanisms of hepatocellular carcinoma (HCC) carcinogenesis are still not fully understood. DNA repair defects may influence HCC risk. The aim of the study was to look for potential genetic variants of DNA repair genes associated with HCC risk among patients with alcohol- or viral-induced liver disease. We performed four case-control studies on 2,006 European- (Derivation#1 and #2 studies) and African-ancestry (Validation#1 and #2 studies) patients originating from several cohorts in order to assess the association between genetic variants on DNA repair genes and HCC risk using a custom array encompassing 94 genes...
September 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28959160/selection-of-non-small-cell-lung-cancer-patients-for-intercalated-chemotherapy-and-tyrosine-kinase-inhibitors
#3
Matjaz Zwitter, Antonio Rossi, Massimo Di Maio, Maja Pohar Perme, Gilberto Lopes
BACKGROUND: When treating patients with advanced non-small cell lung cancer (NSCLC) with tyrosine kinase inhibitors and chemotherapy, intercalated schedule with time separation between the two classes of drugs should avoid their mutual antagonism. In a survey of published trials, we focus on relation between eligibility criteria and effectiveness of intercalated treatment. METHODS: Published documents were identified using major medical databases, conference proceedings and references of published trials...
September 2017: Radiology and Oncology
https://www.readbyqxmd.com/read/28943456/permethrin-pesticide-induces-nurr1-up-regulation-in-dopaminergic-cell-line-is-the-pro-oxidant-effect-involved-in-toxicant-neuronal-damage
#4
Laura Bordoni, Donatella Fedeli, Cinzia Nasuti, Melania Capitani, Dennis Fiorini, Rosita Gabbianelli
The mechanisms associated to the development of neurodegeneration due to pesticide exposure are not clear yet. In this study we evaluated how permethrin pesticide (PERM) can influence the Nurr1 gene and protein expression, and if a pro-oxidant activity of the pesticide contributes to up-regulation of Nurr1 in a dopaminergic cell line. Incubation of PC12 cells with 1μM PERM for 72h, leads to over expression of Nurr1 gene. This effect occurs with both corn oil and extra virgin olive oil (EVO) used to solubilize the toxicant...
September 22, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28921571/comparing-touch-senses-of-na%C3%A3-ve-and-expert-panels-through-treated-hair-swatches-which-associated-wordings-correlate-with-hair-physical-properties
#5
Anthony Galliano, Jean Yves Kempf, Maxime Fougere, Mara Applebaum, Leszek J Wolfram, Howard Maibach
OBJECTIVES: The study i) compared sense of touch between a naïve and an expert panels, under visual or blind conditions, using differently treated hair swatches, ii) explored possible common wordings used by both panels and their possible links with some physical properties of hairs. METHODS: Two sets of 15 hair swatches of Caucasian and Chinese origins were differently treated (bleached, permed, brushed, etc) or organized (root-tip vs tip-root). These were evaluated by tactile assessments by two panels (105 naïve consumers and 10 hair experts) under visual or blind conditions, in two geographic locations...
September 16, 2017: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/28921374/prostate-cancer-clinical-presentation-incidence-mortality-and-survival-in-guadeloupe-over-the-period-2008-2013-from-a-population-based-cancer-registry
#6
J Deloumeaux, B Bhakkan, R Eyraud, F Braud, N Manip M'Ebobisse, P Blanchet, L Brureau
PURPOSE: The Caribbean population of Guadeloupe has one of the highest incidence rates of prostate cancer worldwide. In 2008, a population-based cancer registry was set up for the monitoring of cancer incidence in the aftermath of the environmental pollution with chlordecone, a persistent organochlorine insecticide formerly used in banana plantations. We describe the clinical presentation, incidence, mortality and survival of prostate cancer for the period 2008-2013. METHODS: The Guadeloupe cancer registry has been routinely collecting all incident cases of cancer since 2008...
September 18, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28914690/incidence-trends-and-survival-of-skin-melanoma-and-squamous-cell-carcinoma-in-cluj-county-romania
#7
Ofelia Şuteu, Mihaiela L Blaga, Florian Nicula, Patricia Şuteu, Ovidiu Coza, Patriciu Achimaş-Cadariu, Daniela Coza
The aim of this study was to determine the incidence trends of cutaneous melanoma (CM) and squamous cell carcinoma (SCC) in Cluj County, from 1998 to 2011, and the 5-year net survival between 2006 and 2010. Data on all cases of CM and SCC between 1998 and 2011 were obtained from Cluj Cancer Registry. Incidence rates were age standardized by the direct method Age Standardized Incidence Rate (ASIR), using the world standard population. Trends and annual percentage change (APC) of incidence rates were calculated by joinpoint regression analysis...
September 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28910945/-nested-case-control-study-on-associated-factors-for-anemia-during-pregnancy
#8
C L Fan, J Y Luo, W J Gong, X Q Liu, S J Zhou, F F Zhang, J Zeng, H X Li, N Feng
Objective: To explore the related factors of anemia during pregnancy and provide scientific evidence for the primary prevention of anemia during pregnancy. Methods: The pregnant women (≤12 pregnant weeks) who received the first pregnancy care in a local medical institution in Hunan province from June 2013 to November 2014 were included in this cohort study, and for them anemia had been excluded by physical examination. Baseline survey and follow up till childbirth were conducted for them. A queue-based nested case-control study (1 ∶ 2) was conducted (380 pregnant women with anemia detected in this study as case group, 760 pregnant women without anemia randomly selected and matched by age, habitual residence during pregnancy as control group...
September 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28898817/long-term-trends-in-incidence-and-survival-of-penile-cancer-in-france
#9
Laetitia Daubisse-Marliac, Marc Colonna, Brigitte Trétarre, Gautier Defossez, Florence Molinié, Karine Jéhannin-Ligier, Emilie Marrer, Pascale Grosclaude
BACKGROUND: Penile cancer is rare, and few population-based studies have described changes in time trend. This study aims to determine whether there has been an evolution in incidence and survival of penile cancer over time in France. METHODS: Rates of age world-standardized incidence (ASRW) and net survival (NS) between 1989 and 2011 were calculated using data from 16 French cancer registries. Time trend incidence and survival analysis were confined to the eight registries operating throughout the full period...
September 9, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28871263/the-activity-of-the-neutral-sphingomyelinase-is-important-in-t-cell-recruitment-and-directional-migration
#10
Lena Collenburg, Niklas Beyersdorf, Teresa Wiese, Christoph Arenz, Essa M Saied, Katrin Anne Becker-Flegler, Sibylle Schneider-Schaulies, Elita Avota
Breakdown of sphingomyelin as catalyzed by the activity of sphingomyelinases profoundly affects biophysical properties of cellular membranes which is particularly important with regard to compartmentalization of surface receptors and their signaling relay. As it is activated both upon TCR ligation and co-stimulation in a spatiotemporally controlled manner, the neutral sphingomyelinase (NSM) has proven to be important in T cell activation, where it appears to play a particularly important role in cytoskeletal reorganization and cell polarization...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28796380/thermosensitive-cation-selective-mesochannels-pnipam-capped-mesoporous-thin-films-as-bioinspired-interfacial-architectures-with-concerted-functions
#11
Sonja Schmidt, Sebastián Alberti, Philipp Vana, Galo J A A Soler-Illia, Omar Azzaroni
Rational design and elaborate modular construction of interfacial architectures in which molecular transport is mediated by responsive/adaptive nanostructures has become a growing and fertile field of research in supramolecular materials chemistry. This work presents, for the first time, the use of PNIPAM-capped mesoporous silica thin films as thermosensitive cation-selective mesochannels. Thus far, this feature has only been observed in thermosensitive biological channels. The interfacial architecture created here accomplishes its specific functions through the concerted or simultaneous action of spatially addressed subunits with temperature response and ion exclusion capabilities...
August 10, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28743882/hyperoside-pre-treatment-prevents-glomerular-basement-membrane-damage-in-diabetic-nephropathy-by-inhibiting-podocyte-heparanase-expression
#12
Xiaofei An, Lin Zhang, Yanggang Yuan, Bin Wang, Qiuming Yao, Ling Li, Jisheng Zhang, Ming He, Jinan Zhang
Glomerular basement membrane (GBM) damage plays a pivotal role in pathogenesis of albuminuria in diabetic nephropathy (DN). Heparan sulfate (HS) degradation induced by podocyte heparanase is the major cause of GBM thickening and abnormal perm-selectivity. In the present study, we aimed to examine the prophylactic effect of hyperoside on proteinuria development and GBM damage in DN mouse model and the cultured mouse podocytes. Pre-treatment with hyperoside (30 mg/kg/d) for four weeks could significantly decrease albuminuria, prevent GBM damage and oxidative stress in diabetes mellitus (DM) mice...
July 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28700193/medicaid-chip-program-medicaid-program-and-children-s-health-insurance-program-chip-changes-to-the-medicaid-eligibility-quality-control-and-payment-error-rate-measurement-programs-in-response-to-the-affordable-care-act-final-rule
#13
(no author information available yet)
This final rule updates the Medicaid Eligibility Quality Control (MEQC) and Payment Error Rate Measurement (PERM) programs based on the changes to Medicaid and the Children's Health Insurance Program (CHIP) eligibility under the Patient Protection and Affordable Care Act. This rule also implements various other improvements to the PERM program.
July 5, 2017: Federal Register
https://www.readbyqxmd.com/read/28698651/ion-concentration-polarization-by-bifurcated-current-path
#14
Junsuk Kim, Inhee Cho, Hyomin Lee, Sung Jae Kim
Ion concentration polarization (ICP) is a fundamental electrokinetic process that occurs near a perm-selective membrane under dc bias. Overall process highly depends on the current transportation mechanisms such as electro-convection, surface conduction and diffusioosmosis and the fundamental characteristics can be significantly altered by external parameters, once the permselectivity was fixed. In this work, a new ICP device with a bifurcated current path as for the enhancement of the surface conduction was fabricated using a polymeric nanoporous material...
July 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28674368/thymoma-associated-progressive-encephalomyelitis-with-rigidity-and-myoclonus-perm-with-myasthenia-gravis
#15
Satoshi Morise, Masataka Nakamura, Jun-Ichi Morita, Kousuke Miyake, Takenobu Kunieda, Satoshi Kaneko, Hirofumi Kusaka
We report a case of a 72-year-old woman who initially presented with symptoms of bulbar myasthenia and was positive for anti-acetylcholine receptor antibodies. She subsequently developed painful muscle spasms, myoclonus, and stiffness. Thymoma was detected, and both anti-glycine receptor and anti-glutamic acid decarboxylase antibodies were found. She was diagnosed with thymoma-associated progressive encephalomyelitis with rigidity and myoclonus (PERM). She experienced marked improvement after thymectomy followed by plasma exchange and intravenous immunoglobulin and prednisolone...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28651172/simultaneous-determination-of-cis-permethrin-and-trans-permethrin-in-rat-plasma-and-brain-tissue-using-gas-chromatography-negative-chemical-ionization-mass-spectrometry
#16
Shirin Hooshfar, Darren R Gullick, Michael R Linzey, Tanzir Mortuza, Mona Hamdy Abdel Rahman, Clinton A Rogers, James V Bruckner, Catherine A White, Michael G Bartlett
A sensitive method for the simultaneous determination of cis-permethrin (cis-PERM) and trans-permethrin (trans-PERM) in small volumes (100μL) of rat plasma and brain homogenate was developed, using a liquid-liquid extraction for sample preparation and gas chromatography-negative chemical ionization mass spectrometry (GCNCI-MS) for detection. Quantitation of trace levels of the insecticide in small volumes of biological samples is essential to support toxicokinetic studies in small animals. There are currently no validated methods in the literature for determining cis-PERM and trans- PERM in volumes as low as 100μL of rat plasma or brain homogenate...
August 15, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28636901/the-effect-of-cd34-cell-telomere-length-and-htert-expression-on-the-outcome-of-autologous-cd34-cell-transplantation-in-patients-with-chronic-heart-failure
#17
Jasmina-Ziva Rozman, Maja Pohar Perme, Mojca Jez, Elvira Malicev, Metka Krasna, Srdjan Novakovic, Bojan Vrtovec, Primoz Rozman
Age-related telomere attrition in stem/progenitor cells may diminish their functional capacity and thereby impair the outcome of cell-based therapies. The aim of the present study was to investigate the effect of CD34(+) cell telomere length and hTERT expression on the clinical outcome of autologous CD34(+) cell transplantation. We studied 43 patients with cardiomyopathy. Their peripheral blood CD34(+) cells were mobilized with granulocyte colony-stimulating factor, enriched by immunoselection and delivered transendocardially...
June 19, 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/28617512/a-concentration-independent-micro-nanofluidic-active-diode-using-an-asymmetric-ion-concentration-polarization-layer
#18
Hyekyung Lee, Junsuk Kim, Hyeonsoo Kim, Ho-Young Kim, Hyomin Lee, Sung Jae Kim
Over the past decade, nanofluidic diodes that rectify ionic currents (i.e. greater current in one direction than in the opposite direction) have drawn significant attention in biomolecular sensing, switching and energy harvesting devices. To obtain current rectification, conventional nanofluidic diodes have utilized complex nanoscale asymmetry such as nanochannel geometry, surface charge density, and reservoir concentration. Avoiding the use of sophisticated nano-asymmetry, micro/nanofluidic diodes using microscale asymmetry have been recently introduced; however, their diodic performance is still impeded by (i) low (even absent) rectification effects at physiological concentrations over 100 mM and strong dependency on the bulk concentration, and (ii) the fact that they possess only passive predefined rectification factors...
August 24, 2017: Nanoscale
https://www.readbyqxmd.com/read/28613929/dna-methylation-and-hydroxymethylation-profile-of-cd34-enriched-cell-products-intended-for-autologous-cd34-cell-transplantation
#19
Jasmina-Ziva Rozman, Maja Pohar Perme, Mojca Jez, Elvira Malicev, Metka Krasna, Bojan Vrtovec, Primoz Rozman
Epigenetic dysregulation has been shown to limit functional capacity of aging hematopoietic stem cells, which may contribute to impaired outcome of hematopoietic stem cell-based therapies. The aim of our study was to gain better insight into the epigenetic profile of CD34(+)-enriched cell products intended for autologous CD34(+) cell transplantation in patients with cardiomyopathy. We found global DNA methylation content significantly higher in immunoselected CD34(+) cells compared to leukocytes in leukapheresis products (2...
September 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/28611680/mono-heteromeric-configurations-of-gap-junction-channels-formed-by-connexin43-and-connexin45-reduce-unitary-conductance-and-determine-both-voltage-gating-and-metabolic-flux-asymmetry
#20
Guoqiang Zhong, Nazem Akoum, Daniel A Appadurai, Volodya Hayrapetyan, Osman Ahmed, Agustin D Martinez, Eric C Beyer, Alonso P Moreno
In cardiac tissues, the expression of multiple connexins (Cx40, Cx43, Cx45, and Cx30.2) is a requirement for proper development and function. Gap junctions formed by these connexins have distinct permeability and gating mechanisms. Since a single cell can express more than one connexin isoform, the formation of hetero-multimeric gap junction channels provides a tissue with an enormous repertoire of combinations to modulate intercellular communication. To study further the perm-selectivity and gating properties of channels containing Cx43 and Cx45, we studied two monoheteromeric combinations in which a HeLa cell co-transfected with Cx43 and Cx45 was paired with a cell expressing only one of these connexins...
2017: Frontiers in Physiology
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