keyword
https://read.qxmd.com/read/38545553/berberine-based-self-assembly-agents-with-enhanced-synergistic-antitumor-efficacy
#21
JOURNAL ARTICLE
Yun Wang, Zhongrui Li, Haili Zhang, Peiye Wu, Yu Zhao, Renshi Li, Chao Han, Lei Wang
Tumors are still a major threat to people worldwide. Nanodrug delivery and targeting systems can significantly improve the therapeutic efficacy of chemotherapeutic drugs for antitumor purposes. However, many nanocarriers are likely to exhibit drawbacks such as a complex preparation process, limited drug-loading capacity, untargeted drug release, and toxicity associated with nanocarriers. Therefore, new therapeutic alternatives are urgently needed to develop antitumor drugs. Natural products with abundant scaffold diversity and structural complexity, which are derived from medicinal plants, are important sources of new antitumor drugs...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38545547/aiming-the-magic-bullet-targeted-delivery-of-imaging-and-therapeutic-agents-to-solid-tumors-by-phlip-peptides
#22
REVIEW
Yana K Reshetnyak, Oleg A Andreev, Donald M Engelman
The family of pH (Low) Insertion Peptides (pHLIP) comprises a tumor-agnostic technology that uses the low pH (or high acidity) at the surfaces of cells within the tumor microenvironment (TME) as a targeted biomarker. pHLIPs can be used for extracellular and intracellular delivery of a variety of imaging and therapeutic payloads. Unlike therapeutic delivery targeted to specific receptors on the surfaces of particular cells, pHLIP targets cancer, stromal and some immune cells all at once. Since the TME exhibits complex cellular crosstalk interactions, simultaneous targeting and delivery to different cell types leads to a significant synergistic effect for many agents...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38545295/ionic-liquid-coated-lipid-nanoparticles-increase-sirna-uptake-into-cns-targets
#23
JOURNAL ARTICLE
Purva Khare, Sara X Edgecomb, Christine M Hamadani, James F Conway, Eden E L Tanner, Devika S Manickam
Lipidoid nanoparticles (LNPs) have transformed the field of drug delivery and are clinically used for the delivery of nucleic acids to liver and muscle targets. Post-intravenous administration, LNPs are naturally directed to the liver due to the adsorption of plasma proteins like apolipoprotein E. In the present work, we have re-engineered LNPs with ionic liquids (ILs) to reduce plasma protein adsorption and potentially increase the accumulation of LNPs in hard-to-deliver central nervous system (CNS) targets such as brain endothelial cells (BECs) and neurons...
March 26, 2024: Nanoscale advances
https://read.qxmd.com/read/38545294/a-new-neodymium-complex-on-renewable-magnetic-biochar-nanoparticles-as-an-environmentally-friendly-recyclable-and-efficient-nanocatalyst-in-the-homoselective-synthesis-of-tetrazoles
#24
JOURNAL ARTICLE
Bahman Tahmasbi, Parisa Moradi, Mitra Darabi
Inexpensive, stable, selective, and recyclable nanocatalysts, waste regeneration, and utilization of safe and available solvents are of interest and important factors in laboratory science and industrial applications of green chemistry. Therefore, herein, biochar nanoparticles (BNPs) were synthesized through chicken manure pyrolysis as a novel method for waste recycling. Then, in order to improve their recyclability, the obtained BNPs were magnetized using magnetic nickel nanoparticles. Then, the surface of the biochar magnetic nanoparticles (BMNPs) was modified by (3-chloropropyl)trimethoxysilane (3-CPTMS) and further a novel neodymium Schiff-base complex was immobilized on the surface of the modified BMNPs, denoted as Nd-Schiff-base@BMNPs...
March 26, 2024: Nanoscale advances
https://read.qxmd.com/read/38545285/radiofrequency-absorption-of-coated-ellipsoidal-gold-nanoparticles-in-human-tissue
#25
JOURNAL ARTICLE
Brage Bøe Svendsen, Olle Hennert, Robert Themptander, Mariana Dalarsson
Electromagnetic radiofrequency heating of gold nanoparticles for use in remote hyperthermia cancer treatment has seen rapidly growing interest in the last decade. While most of the focus has been on studying spherical nanoparticles, recent research suggests that using ellipsoidal particles can significantly increase the Joule heating. However, it is still unclear how the presence of ligands affects the electromagnetic absorption in this context. In the present paper, we study the effects of adding a surface coating to ellipsoidal gold nanoparticles, and investigate the change in absorption with respect to coating properties, particle aspect-ratio, and frequency...
March 26, 2024: Nanoscale advances
https://read.qxmd.com/read/38545284/detailed-discussion-on-the-structure-of-alloy-nanoparticles-synthesized-via-magnetron-sputter-deposition-onto-liquid-poly-ethylene-glycol
#26
REVIEW
Mai Thanh Nguyen, Pichaya Pattanasattayavong, Tetsu Yonezawa
This paper is devoted to reviewing a decade of the development of vacuum sputter deposition onto liquid poly(ethylene glycol) (PEG) to prepare metal and alloy nanoparticles (NPs) with a controlled particle growth, size, structure, and composition. Especially, we have discussed the fine structures of alloy NPs obtained in PEG and compared them with those sputtered onto other non-volatile liquids. Finally, we have shared our prospect of applications for the resulting alloy NPs.
March 26, 2024: Nanoscale advances
https://read.qxmd.com/read/38545262/effective-therapy-of-advanced-breast-cancer-through-synergistic-anticancer-by-paclitaxel-and-p-glycoprotein-inhibitor
#27
JOURNAL ARTICLE
Sifeng Zhu, Chao Sun, Zimin Cai, Yunyan Li, Wendian Liu, Yun Luan, Cheng Wang
Multi-drug resistance (MDR) in advanced breast cancer (ABC) is triggered by the high expression of P-glycoprotein (P-gp), which reduces intracellular concentration of anti-tumor drugs, in turn preventing oxidative stress damage to cytoplasmic and mitochondrial membranes. It is therefore of clinical relevance to develop P-gp-specific targeted nanocarriers for the treatment of drug resistant ABC. Herein, a drug carrier targeting CD44 and mitochondria was synthesised for the delivery of encequidar (ER, P-gp inhibitor) and paclitaxel (PTX)...
June 2024: Materials today. Bio
https://read.qxmd.com/read/38545160/research-hotspots-and-trends-of-nanomaterials-in-stomatology-a-bibliometric-analysis-from-2000-to-2023
#28
JOURNAL ARTICLE
Lingyu Liang, Zongpu Han, Ruihan Yang, Yuanlong Guo, Zetao Chen
BACKGROUND: Nanomaterials (NMs) have emerged as highly promising candidates for stomatology due to their excellent quality and remarkable progress in recent years. However, with the rapid expansion of the research scale, challenges arise in the technological decision-making and research management processes, and therefore difficulty for researchers to understand the knowledge structure and research hotspots has increased significantly. This study aims to make a comprehensive summary of authors, institutions, journals, research topics, development trends, and research hotspots of NMs in stomatology through bibliometric analysis for the sake of providing references for scientific decision-making, research management, and academic exploration in this filed...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38545138/gold-nanoparticles-synthesis-mediated-by-fungus-isolated-from-aerobic-granular-sludge-process-and-mechanisms
#29
JOURNAL ARTICLE
Xin Zhao, Ning Hou, Chunli Wan, Lei Zhang, Xiang Liu
Due to the low toxicity, biocompatibility and eco-friendliness, microorganisms have received a lot of attention for gold nanoparticles (AuNPs) synthesis. This work isolated a fungal strain capable of efficiently generating AuNPs from aerobic granular sludge, named XY3. Comparison of 18S rDNA sequence results showed that fungus XY3 belongs to Candida rugopelliculosa . AuNPs were synthesized by initiating an Au3+ -induced stress response that prompted the reduction of Au3+ to Au0 by the fungus XY3. It is worth noting that the addition of nutritional substrates weakens the stress response induced by Au3+ , resulting in a decrease in the yield of AuNPs...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38545103/host-functionalization-of-macrin-nanoparticles-to-enable-drug-loading-and-control-tumor-associated-macrophage-phenotype
#30
JOURNAL ARTICLE
Biplab Sarkar, Sean P Arlauckas, Michael F Cuccarese, Christopher S Garris, Ralph Weissleder, Christopher B Rodell
Macrophages are critical regulators of the tumor microenvironment and often present an immuno-suppressive phenotype, supporting tumor growth and immune evasion. Promoting a robust pro-inflammatory macrophage phenotype has emerged as a therapeutic modality that supports tumor clearance, including through synergy with immune checkpoint therapies. Polyglucose nanoparticles (macrins), which possess high macrophage affinity, are useful vehicles for delivering drugs to macrophages, potentially altering their phenotype...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38545092/efficacy-and-safety-of-phospholipid-nanoparticles-vbi-s-in-reversing-intractable-hypotension-in-patients-with-septic-shock-a-multicentre-open-label-repeated-measures-phase-2a-clinical-pilot-trial
#31
JOURNAL ARTICLE
Cuthbert Simpkins, Michael Moncure, Heather Klepacz, Kristopher Roach, Sadia Benzaquen, Luis Diaz-Caballero, Jonathan Cohen, Daniel Haase, Mukesh Kumar, Harven DeShield, Anthony Manasia, Juan Rodriguez, Prashanth Anamthathmakula, Nik Hurt, Bhaswati Mukherjee, Krishna Talluri
BACKGROUND: Since the 1990's attempts to favorably modulate nitric oxide (NO) have been unsuccessful. We hypothesized that because NO is lipophilic it would preferentially localize into intravascularly infused hydrophobic nanoparticles, thereby reducing its bioavailability and adverse effects without inhibiting its production. We aimed to determine the efficacy and safety of intravenous infusion of a fluid comprised of hydrophobic phospholipid nanoparticles (VBI-S) that reversibly absorb NO in the treatment of hypotension of patients in severe septic shock...
February 2024: EClinicalMedicine
https://read.qxmd.com/read/38544982/a-gmr-enzymatic-assay-for-quantifying-nuclease-and-peptidase-activity
#32
JOURNAL ARTICLE
Michael Sveiven, Ana K Serrano, Joshua Rosenberg, Douglas J Conrad, Drew A Hall, Anthony J O'Donoghue
Hydrolytic enzymes play crucial roles in cellular processes, and dysregulation of their activities is implicated in various physiological and pathological conditions. These enzymes cleave substrates such as peptide bonds, phosphodiester bonds, glycosidic bonds, and other esters. Detecting aberrant hydrolase activity is vital for understanding disease mechanisms and developing targeted therapeutic interventions. This study introduces a novel approach to measuring hydrolase activity using giant magnetoresistive (GMR) spin valve sensors...
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38544977/a-review-of-antibody-aptamer-and-nanomaterials-synergistic-systems-for-an-amplified-electrochemical-signal
#33
REVIEW
Resmond L Reaño, Erwin C Escobar
The synergy between biomolecules with inorganic nanomaterials and nanoparticles has been investigated over the past years, primarily to improve biomarker reception, generate signals, and amplify the signals generated. In this paper, several articles on aptamer-based and antibody-based electrochemical biosensors that target antigens were examined. Among the key characteristics identified were the electrochemical platform development, which includes the usage of nanomaterials as electroactive or electrocatalytic labels, crosslinking of the biological agent with inorganic compounds, and electrode coating to provide an electronic source and support efficient electron transfer...
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38544951/coordinated-asbt-and-egfr-mechanisms-for-optimized-liraglutide-nanoformulation-absorption-in-the-gi-tract
#34
JOURNAL ARTICLE
Seho Kweon, Seong Jin Park, Ha Kyeong Lee, Seo Hee Kang, Kwan-Young Chang, Jeong Uk Choi, Jooho Park, Jung-Hyun Shim, Jin Woo Park, Youngro Byun
BACKGROUND: For maintenance therapy in type 2 diabetes, glucagon-like peptide-1 agonist (GLP-1A), which exhibits low cardiovascular risk and high efficacy, is a promising peptide therapeutic. However, developing an oral GLP-1A presents challenges due to the analog's poor cellular permeability and gastrointestinal (GI) stability. METHODS: To mitigate such limitations, an oral nanoformulation of liraglutide (LG) was designed and achieved by combining LG with bile acid derivatives using the nanoprecipitation method...
2024: International Journal of Nanomedicine
https://read.qxmd.com/read/38544935/colorimetric-sensor-array-for-the-rapid-distinction-and-detection-of-various-antibiotic-resistant-psychrophilic-bacteria-in-raw-milk-based-on-machine-learning
#35
JOURNAL ARTICLE
Yanan Qin, Jingshuai Sun, Wanting Huang, Haitao Yue, Fanxing Meng, Minwei Zhang
In this study, a rapid, inexpensive, and accurate colorimetric sensor for detecting psychrophilic bacteria was designed, comprising gold (Au) nanoparticles (NPs) modified by d-amino acid (D-AA) as color-metric probes. Based on the aggregation of Au NPs induced by psychrophilic bacteria, a noticeable color shift occurred within 6 h. Depending on the various metabolic behaviors of bacteria to different D-AA, four primary psychrophilic bacteria in raw milk were successfully distinguished by learning the response patterns...
June 30, 2024: Food chemistry: X
https://read.qxmd.com/read/38544893/chromium-speciation-in-water-using-magnetic-polyaniline-nanoparticles-coupled-with-microsampling-injection-flame-atomic-absorption-spectroscopy
#36
JOURNAL ARTICLE
Osman Çaylak
The chromium speciation procedure was optimized using magnetic polyaniline nanoparticles (Fe3 O4 @PANI NPs) solid-phase extraction coupled with microsampling injection-flame atomic absorption spectrometry (MIS-FAAS). Chromium speciation was successfully achieved by Fe3 O4 @PANI NPs at pH 8.0. The recoveries obtained for Cr(III) and Cr(VI) were above 95% and under 5%, respectively. Recoveries of over 95% for Cr(III) from 40.0 mL of the sample were obtained using 25 mg Fe3 O4 @PANI NPs and 500 μL of 0.2% (w/v) thiourea (TU) solution prepared in 2 mol L-1 HCl as eluent...
2024: Turkish Journal of Chemistry
https://read.qxmd.com/read/38544891/palladium-0-nanoparticles-distributed-on-lanthanum-iii-oxide-as-an-effective-catalyst-for-the-methanolysis-of-hydrazine-borane-to-produce-hydrogen
#37
JOURNAL ARTICLE
Adem Rüzgar, Lokman Şener, Yaşar Karataş, Mehmet Gülcan
Pd (0) nanoparticles (NPs) distributed on lanthanum (III) oxide were ex situ generated from the reduction of Pd2+ ions using NaBH4 as reducing agent. The Pd/La2 O3 displayed good catalytic activity in H2 (g) releasing from the hydrazine-borane (HB) methanolysis reaction and it was identified by advanced techniques. Pd/La2 O3 was found to be an active catalyst procuring three equiv. H2 (g) per mole of HB. The results from TEM images represent the formation of Pd (0) NPs with an average particle size of 1.94 ± 0...
2024: Turkish Journal of Chemistry
https://read.qxmd.com/read/38544887/synthesis-and-characterization-of-surface-modified-magnetic-mesoporous-silicate-materials-for-phosphate-adsorption
#38
JOURNAL ARTICLE
Ayşegül Gençer, Burcu Uysal Karataş, Önder Topel, Nadir Kiraz
The magnetic mesoporous silica material, Mag-MCM-41, was synthesized by coating magnetite (Fe3 O4 ) nanoparticles with a mesoporous material called MCM-41. Mag-MCM-41 and modified nanomaterials Mag-MCM-41-NN and Mag-MCM-41-NN-Fe+3 which were modified with aminopropyl functional groups. In water and wastewater, phosphate anions are considered significant contaminants due to their detrimental impact on the environment. They promote the growth of algae, leading to eutrophication. The purpose of this study is to investigate the removal of phosphate anions from aqueous solutions using modified magnetic silica particles...
2024: Turkish Journal of Chemistry
https://read.qxmd.com/read/38544742/silver-nanoparticles-synthesized-from-pseudomonas-aeruginosa-pyoverdine-antibiofilm-and-antivirulence-agents
#39
JOURNAL ARTICLE
Nazia Tabassum, Fazlurrahman Khan, Geum-Jae Jeong, Du-Min Jo, Young-Mog Kim
The increasing incidence of antimicrobial resistance exhibited by biofilm-forming microbial pathogens has been recognized as one of the major issues in the healthcare sector. In the present study, nanomaterial-based controlling the biofilm and virulence properties has been considered an alternative approach. Pyoverdine (PVD) isolated from the Pseudomonas aeruginosa was utilized as a biological corona to synthesize silver nanoparticles (AgNPs), which will be helpful in a targeted action to microbial pathogens due to the recognition of the corona of the nanoparticles by the pathogenic membrane...
June 2024: Biofilm
https://read.qxmd.com/read/38544700/thermally-induced-morphological-and-structural-transformations-on-eu-2-eu-3-coactivated-calcium-silicate-nanophosphors
#40
JOURNAL ARTICLE
Hyun-Joo Woo, Kay Hadrick, Taeho Kim
This study presents an approach for synthesizing Eu2+ /Eu3+ -coactivated Ca2 SiO4 nanophosphors, by adjusting the ratio of both activators within a singular host material. Utilizing a hydrothermal method complemented by a postreduction sintering process, we fabricated a series of phosphors characterized by uniform 30-50 nm spherical nanoparticles. These engineered phosphors manifest multichannel luminescence properties and exhibit simultaneous blue and red emission from Eu2+ and Eu3+ , respectively. Meticulous control of the 5% H2 -95% N2 reduction temperature allowed for precise tuning of the Eu2+ and Eu3+ ions within the host lattice, which enabled the strategic adjustment of their luminescent outputs...
March 22, 2024: ACS Appl Opt Mater
keyword
keyword
11605
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.