Cuthbert Simpkins, Michael Moncure, Heather Klepacz, Kristopher Roach, Sadia Benzaquen, Luis Diaz-Caballero, Jonathan Cohen, Daniel Haase, Mukesh Kumar, Harven DeShield, Anthony Manasia, Juan Rodriguez, Prashanth Anamthathmakula, Nik Hurt, Bhaswati Mukherjee, Krishna Talluri
BACKGROUND: Since the 1990's attempts to favorably modulate nitric oxide (NO) have been unsuccessful. We hypothesized that because NO is lipophilic it would preferentially localize into intravascularly infused hydrophobic nanoparticles, thereby reducing its bioavailability and adverse effects without inhibiting its production. We aimed to determine the efficacy and safety of intravenous infusion of a fluid comprised of hydrophobic phospholipid nanoparticles (VBI-S) that reversibly absorb NO in the treatment of hypotension of patients in severe septic shock...
February 2024: EClinicalMedicine