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https://www.readbyqxmd.com/read/29141366/-in-vitro-early-detection-of-amyloid-plaques-in-alzheimer-s-disease-by-pittsburgh-compound-b-modified-magnetic-nanoparticles
#1
J Q Zeng, J Q Wu, M H Li, P J Wang
Objective: To construct magnetic nanoparticles targeting β-amyloid (Aβ) plaques, the pathological biomarker of Alzheimer's disease (AD) and to study their binding capability in vitro. Methods: Superparamagnetic nanoparticles Mn(0.6)Zn(0.4)Fe(2)O(4) (MZF) were coated with amphiphilic star-block copolymeric micelles and modified with Aβ-specific probe Pittsburgh compound B (PiB) to construct a novel magnetic nanoparticle MZF-PiB, which specifically targeted amyloid plaques. Transmission electron microscope was used to study the morphological features of MZF-PiB...
November 7, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29141151/light-responsive-nanoparticles-for-highly-efficient-cytoplasmic-delivery-of-anticancer-agents
#2
Yangyun Wang, Yibin Deng, Huanhuan Luo, Aijun Zhu, Hengte Ke, Hong Yang, Huabing Chen
Stimuli-responsive nanostructures have shown great promise for intracellular delivery of anticancer compounds. A critical challenge remains in the exploration of stimuli-responsive nanoparticles for fast cytoplasmic delivery. Herein, near-infrared (NIR) light-responsive nanoparticles were rationally designed to generate highly efficient cytoplasmic delivery of anticancer agents for synergistic thermo-chemotherapy. The drug-loaded polymeric nanoparticles of selenium-inserted copolymer (I/D-Se-NPs) were rapidly dissociated in several minutes through reactive oxygen species (ROS)-mediated selenium oxidation upon NIR light exposure, and this irreversible dissociation of I/D-Se-NPs upon such a short irradiation promoted continuous drug release...
November 15, 2017: ACS Nano
https://www.readbyqxmd.com/read/29141149/surface-modification-of-cisplatin-complexed-gold-nanoparticles-and-its-influence-on-colloidal-stability-drug-loading-and-release
#3
Jiaojie Tan, Tae Joon Cho, De-Hao Tsai, Jingyu Liu, John M Pettibone, Rian You, Vincent A Hackley, Michael R Zachariah
Cisplatin-complexed gold nanoparticles (PtII-AuNP) provide a promising strategy for chemo-radiation based anticancer drugs. Effective design of such platforms necessitates reliable assessment of surface engineering on a quantitative basis, and its influence on drug payload, stability and release. In this paper, polyethylene glycol (PEG) stabilized PtII-AuNP was synthesized as a model anti-tumor drug platform, where PtII is attached via a carboxyl terminated dendron ligand. Surface modification by PEG and its influence on drug loading, colloidal stability and drug release were assessed...
November 15, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29141148/plasmonically-enhanced-galactoxyloglucan-endowed-gold-nanoparticles-exposed-tumor-targeting-biodistribution-envisaged-in-a-surface-enhanced-raman-scattering-platform
#4
Manu M Joseph, Jyothi B Nair, Kaustabh Kumar Maiti, Sreelekha Therakathinal T
Biopolymer capped gold nanoparticles (AuNPs) were perceived for tracing biodistribution in a solid tumor mice through surface-enhanced Raman scattering (SERS) fingerprinting. In this strategy, a robust and ecofriendly green chemistry approach was adopted to construct galactoxyloglucan (PST001) endowed AuNPs (PST-GNPs) with cancer-cell-selective toxic nature and excellent biocompatibility. Plasmonically enhanced light scattering properties facilitated PST-GNPs to be a superior SERS substrate with high Raman signal enhancement...
November 15, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/29141144/engineering-interface-with-one-dimensional-co3o4-nanostructure-in-catalytic-membrane-electrode-towards-an-advanced-electrocatalyst-for-alcohol-oxidation
#5
Zhen Yin, Yumei Zheng, Hong Wang, Jianxin Li, Qingjun Zhu, Ye Wang, Na Ma, Gang Hu, Benqiao He, Axel Knop-Gericke, Robert Schloegl, Ding Ma
Electrochemical oxidation has attracted vast interests as a promising alternative to traditional chemical processes in fine chemical synthesis owing to its fast and sustainable features. An electrocatalytic membrane reactor (ECMR) with a three-dimensional (3D) electrode has been successfully designed for the selective oxidation of alcohols with high current efficiency to the corresponding acids or ketones. The anode electrode was fabricated by the in-situ loading of one-dimensional (1D) Co3O4 nanowires (NWs) on the conductive porous Ti membrane (Co3O4 NWs/Ti) via the combination of a facile hydrothermal synthesis and subsequent thermal treatment...
November 15, 2017: ACS Nano
https://www.readbyqxmd.com/read/29141139/the-effect-of-synthetic-high-density-lipoproteins-modification-with-polyethylene-glycol-on-pharmacokinetics-and-pharmacodynamics
#6
Dan Li, Maria V Fawaz, Emily E Morin, Ran Ming, Denis Sviridov, Jie Tang, Rose Ackerman, Karl Olsen, Alan T Remaley, Anna Schwendeman
Synthetic high density lipoprotein nanoparticles (sHDL) capable of mobilizing excess cholesterol from atherosclerotic arteries and delivering it to the liver for elimination have been shown to reduce plaque burden in patients. Unfortunately, sHDLs have a narrow therapeutic index and relative to the endogenous HDL shorter circulation half-life. Surface modification with polyethylene glycol (PEG) was investigated for its potential to extend sHDL circulation in vivo. Various amounts (2.5, 5 and 10%) and different chain lengths (2 and 5 kDa) of PEG-modified lipids were incorporated in sHDL's lipid membrane...
November 15, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29141136/systemic-mrna-delivery-to-the-lungs-by-functional-polyester-based-carriers
#7
Yunfeng Yan, Hu Xiong, Xinyi Zhang, Qiang Cheng, Daniel John Siegwart
Messenger RNA (mRNA) has recently come into focus as an emerging therapeutic class with great potential for protein replacement therapy, cancer immunotherapy, regenerative medicine, vaccines, and gene editing. However, the lack of effective and safe delivery methods impedes the broad application of mRNA-based therapeutics. Here, we report a robust approach to develop efficient polymeric delivery carriers for mRNA. Lead polyesters were identified by in vitro screening of a 480-member combinatorially modified poly(trimethylolpropane allyl ether-co-suberoyl chloride) library for the delivery of luciferase encoding mRNA (Luc mRNA) to IGROV1 cells...
November 15, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/29141114/ph-ultrasound-dual-responsive-gas-generator-for-ultrasound-imaging-guided-therapeutic-inertial-cavitation-and-sonodynamic-therapy
#8
Qianhua Feng, Wanxia Zhang, Xuemei Yang, Yuzhen Li, Yongwei Hao, Hongling Zhang, Lin Hou, Zhenzhong Zhang
Herein, a pH/ultrasound dual-responsive gas generator is reported, which is based on mesoporous calcium carbonate (MCC) nanoparticles by loading sonosensitizer (hematoporphyrin monomethyl ether (HMME)) and modifying surface hyaluronic acid (HA). After pinpointing tumor regions with prominent targeting efficiency, HMME/MCC-HA decomposes instantaneously under the cotriggering of tumoral inherent acidic condition and ultrasound (US) irradiation, concurrently accompanying with CO2 generation and HMME release with spatial/temporal resolution...
November 15, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29140828/biomimetic-nanoparticles-for-transplantation-tolerance
#9
Silvia Minardi, Sahil Shah, Xunrong Luo
PURPOSE OF REVIEW: The current review aims to provide a current landscape and future trends of biomimetic nanoparticles which have the potential to revolutionize the field of transplantation in the next decade. RECENT FINDINGS: Currently, the inability to safely induce robust donor-specific immunological tolerance makes it difficult to achieve immunosuppression-free graft survival. Despite progresses in the development of nanotherapeutics for antigen-specific immunomodulation in autoimmune diseases and in cancer treatments, few have been proposed and tested in transplantation with success...
November 14, 2017: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/29140713/direct-observation-of-plasmon-induced-interfacial-charge-separation-in-metal-semiconductor-hybrid-nanostructures-by-measuring-surface-potentials
#10
Seung-Hoon Lee, Seung Woo Lee, Taegon Oh, Sarah Hurst Petrosko, Chad A Mirkin, Jae-Won Jang
Plasmon-induced interfacial charge separation (PICS) is one of the key processes responsible for the improved conversion efficiencies of energy-harvesting devices that incorporate metal nanostructures. In this letter, we reveal a mechanism of PICS by visualizing (with nanometer-scale resolution) and characterizing plasmon-exciton coupling between p-type poly(pyrrole) (PPy) nanowires (NWs) and Ag nanoparticles (NPs) using light-irradiated Kelvin probe force microscopy (KPFM). Under blue-light irradiation, the Ag NPs are expected to donate electrons to the PPy NWs via a hot electron injection process...
November 15, 2017: Nano Letters
https://www.readbyqxmd.com/read/29140711/probing-the-surface-charge-on-the-basal-planes-of-kaolinite-particles-with-high-resolution-atomic-force-microscopy
#11
Naveen Kumar, Martin Peter Andersson, Dirk van den Ende, Frieder Mugele, Igor Siretanu
High resolution Atomic Force Microscopy is used to map the surface charge on the basal planes of kaolinite nanoparticles in an ambient solution of variable pH and NaCl or CaCl2 concentration. Using DLVO theory with charge regulation we determine from the measured force-distance curves the surface charge distribution on both the silica-like and the gibbsite-like basal plane of the kaolinite particles. We observe that both basal planes do carry charge that varies with pH and salt concentration. The silica facet was found to be negatively charged at pH 4 and above, whereas the gibbsite facet is positively charged at pH below 7, and negatively charged at pH above 7...
November 15, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29140684/janus-gold-nanoplatform-for-synergetic-chemoradiotherapy-and-computed-tomography-imaging-of-hepatocellular-carcinoma
#12
Zheng Wang, Dan Shao, Zhimin Chang, Mengmeng Lu, Yingshuai Wang, Juan Yue, Dian Yang, Mingqiang Li, Qiaobing Xu, Wenfei Dong
There is a pressing need to develop nanoplatforms that integrate multimodal therapeutics to improve treatment responses and prolong the survival of patients with unresectable hepatocellular carcinoma (HCC). Mesoporous silica-coated gold nanomaterials have emerged as a novel multifunctional platform combining tunable surface plasmon resonance and mesoporous properties that exhibit multimodality properties in cancer theranostics. However, their reduced radiation-absorption efficiency and limited surface area hinder their further radiochemotherapeutic applications...
November 15, 2017: ACS Nano
https://www.readbyqxmd.com/read/29140682/molecular-patterning-and-directed-self-assembly-of-gold-nanoparticles-on-gaas
#13
Tianhan Liu, Timothy D Keiper, Xiaolei Wang, Guang Yang, Daniel T Hallinan, Jianhua Zhao, Peng Xiong
The ability to create micro/nano patterns of organic self-assembled monolayers (SAMs) on semiconductor surfaces is crucial for fundamental studies and applications in a number of emerging fields in nanoscience. Here, we demonstrate the direct patterning of thiolate SAMs on oxide-free GaAs surface by dip-pen nanolithography (DPN) and micro-contact printing (μCP), facilitated by a process of surface etching and passivation of the GaAs. A quantitative analysis on the molecular diffusion on GaAs was conducted by examining the writing of nanoscale dot and line patterns by DPN, which agrees well with surface diffusion models...
November 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29140677/synthesis-of-multi-au-nanoparticles-embedded-mesoporous-silica-microspheres-as-self-filtering-and-reusable-substrates-for-sers-detection
#14
Miao Chen, Wen Luo, Zhimin Zhang, Ranhao Wang, Yuqiu Zhu, Hua Yang, Xiaoqing Chen
Surface-enhanced Raman scattering (SERS) based biosensing in biological fluids is constrained by nonspecific macromolecules adsorptions and disposable property of the SERS substrate. Here, novel multi-Au nanoparticles-embedded mesoporous silica microspheres (AuNPs/mSiO2) was prepared using a one-pot method, which served as reliable substrates for SERS enhancement associated with salient features of self-filtering ability and reusability. The fabrication and physical characterization of AuNPs/mSiO2 microspheres were discussed, and SERS activity of this novel substrates was investigated by using 4-mercaptobenzoic acid (4-MBA) as Raman probe...
November 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29140308/synergistic-effect-of-fluorinated-and-n-doped-tio%C3%A2-nanoparticles-leading-to-different-microstructure-and-enhanced-photocatalytic-bacterial-inactivation
#15
Irena Milosevic, Amarnath Jayaprakash, Brigitte Greenwood, Birgit van Driel, Sami Rtimi, Paul Bowen
This work focuses on the development of a facile and scalable wet milling method followed by heat treatment to prepare fluorinated and/or N-doped TiO₂ nanopowders with improved photocatalytic properties under visible light. The structural and electronic properties of doped particles were investigated by various techniques. The successful doping of TiO₂ was confirmed by X-ray photoelectron spectroscopy (XPS), and the atoms appeared to be mainly located in interstitial positions for N whereas the fluorination is located at the TiO₂ surface...
November 15, 2017: Nanomaterials
https://www.readbyqxmd.com/read/29140296/microstructure-mechanical-and-tribological-properties-of-oxide-dispersion-strengthened-high-entropy-alloys
#16
Xinyu Liu, Hangboce Yin, Yi Xu
A novel metal matrix composite CrMnFeCoNi with Y₂O₃ as reinforcement phase was designed and manufactured by mechanical alloying and spark plasma sintering. After sintering at 900 °C for 5 min, the microstructure consisted of a FCC matrix and Y₂O₃ nanoparticles. The addition of 0.25 wt % Y₂O₃ increased the room temperature tensile strength of the CrMnFeCoNi base from 868 MPa to 1001 MPa, while the mechanical properties of the addition of 0.5 wt % Y₂O₃ composite decreased. In the meantime, the addition of Y₂O₃ had no significant influence on the coefficient of friction, while the addition of 0...
November 15, 2017: Materials
https://www.readbyqxmd.com/read/29140287/interaction-between-diethyldithiocarbamate-and-cu-ii-on-gold-in-non-cyanide-wastewater
#17
Nguyễn Hoàng Ly, Thanh Danh Nguyen, Kyung-Duk Zoh, Sang-Woo Joo
A surface-enhanced Raman scattering (SERS) detection method for environmental copper ions (Cu(2+)) was developed according to the vibrational spectral change of diethyldithiocarbamate (DDTC) on gold nanoparticles (AuNPs). The ultraviolet-visible (UV-Vis) absorption spectra indicated that DDTC formed a complex with Cu(2+), showing a prominent peak at ~450 nm. We found Raman spectral changes in DDTC from ~1490 cm(-1) to ~1504 cm(-1) on AuNPs at a high concentration of Cu(2+) above 1 μM. The other ions of Zn(2+), Pb(2+), Ni(2+), NH₄⁺, Mn(2+), Mg(2+), K⁺, Hg(2+), Fe(2+), Fe(3+), Cr(3+), Co(2+), Cd(2+), and Ca(2+) did not produce such spectral changes, even after they reacted with DDTC...
November 15, 2017: Sensors
https://www.readbyqxmd.com/read/29140285/chitosan-cyclodextrin-tpp-nanoparticles-loaded-with-quercetin-as-novel-bacterial-quorum-sensing-inhibitors
#18
Hao Thanh Nguyen, Francisco M Goycoolea
The widespread emergence of antibiotic-resistant bacteria has highlighted the urgent need of alternative therapeutic approaches for human and animal health. Targeting virulence factors that are controlled by bacterial quorum sensing (QS), seems a promising approach. The aims of this study were to generate novel nanoparticles (NPs) composed of chitosan (CS), sulfo-butyl-ether-β-cyclodextrin (Captisol(®)) and/or pentasodium tripolyphosphate using ionotropic gelation technique, and to evaluate their potential capacity to arrest QS in bacteria...
November 15, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29140244/subcellular-analysis-of-pigeon-hair-cells-implicates-vesicular-trafficking-in-cuticulosome-formation-and-maintenance
#19
Simon Nimpf, Erich Pascal Malkemper, Mattias Lauwers, Lyubov Ushakova, Gregory Nordmann, Andrea Wenninger-Weinzierl, Thomas R Burkard, Sonja Jacob, Thomas Heuser, Guenter P Resch, David A Keays
Hair cells are specialized sensors located in the inner ear that enable the transduction of sound, motion, and gravity into neuronal impulses. In birds some hair cells contain an iron-rich organelle, the cuticulosome, that has been implicated in the magnetic sense. Here, we exploit histological, transcriptomic and tomographic methods to investigate the development of cuticulosomes, as well as the molecular and subcellular architecture of cuticulosome positive hair cells. We show that this organelle forms rapidly after hatching in a process that involves vesicle fusion and nucleation of ferritin nanoparticles...
November 15, 2017: ELife
https://www.readbyqxmd.com/read/29139486/simple-and-rapid-colorimetric-detection-of-melanoma-circulating-tumor-cells-using-bifunctional-magnetic-nanoparticles
#20
Junrong Li, Jing Wang, Yuling Wang, Matt Trau
Circulating tumor cells (CTCs) are a promising biomarker for monitoring cancer metastasis and therapy response. However, the rarity and inherent fragility of CTCs pose great challenges for CTC detection. Currently, CTC detection requires advanced instruments that might be inaccessible in most hospitals or labs. To allow simple and rapid CTC detection, we propose a sensor platform that relies only on the intrinsic properties of magnetic nanoparticles (MNPs) including rapid separation as well as nanozyme activity...
November 15, 2017: Analyst
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