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https://www.readbyqxmd.com/read/29353431/sensitive-electrochemical-detection-of-microrna-21-based-on-propylamine-functionalized-mesoporous-silica-with-glucometer-readout
#1
Kun Deng, Yong Zhang, Xuedong Tong
A new homogeneous electrochemical sensing system was developed for sensitive detection of microRNA-21 (miRNA-21) based on target-induced glucose release from propylamine-functionalized mesoporous silica nanoparticle (MSN) with glucometer readout. Glucose molecules (as the signal tracers) were initially gated into the pores through the interaction of the negatively charged anchor DNA with the aminated MSN. Upon addition of target miRNA, the analyte competitively hybridized with anchor DNA to form the RNA-DNA duplex, thus resulting in detachment of anchor DNA from the MSN accompanying the pore opening...
January 20, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29353430/multiplex-highly-sensitive-immunochromatographic-assay-based-on-the-use-of-nonprocessed-antisera
#2
Nadezhda A Byzova, Alexandr E Urusov, Anatoly V Zherdev, Boris B Dzantiev
The format of an immunochromatographic multiassay is first proposed with native antisera and a universal conjugate of antispecies antibodies with gold nanoparticles. This format allows (1) the exclusion of purification and conjugation stages for specific antibodies and (2) significant reduction of the concentration of specific antibodies in the system. The independent use of specific antibodies and a conjugated marker provided a low detection limit and high signal intensity. The proposed format was implemented for the simultaneous detection of two herbicides...
January 20, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29353285/laser-scanning-microscopic-investigations-of-the-decontamination-of-soot-nanoparticles-from-the-skin
#3
Jürgen Lademann, Fanny Knorr, Alexa Patzelt, Martina C Meinke, Heike Richter, Jean Krutmann, Eckart Rühl, Olivier Doucet
BACKGROUND/AIMS: Airborne pollutants, such as nano-sized soot particles, are increasingly being released into the environment as a result of growing population densities and industrialization. They can absorb organic and metal compounds with potential biological activity, such as polycyclic aromatic hydrocarbons and airborne pollen allergens. Local and systemic toxicities may be induced in the skin if the particulates release their harmful components upon dermal contact. METHODS: In the present study, skin pretreatments with serum and/or shield as barrier formulations prior to exposure and washing with a cleanser subsequent to exposure were evaluated as a protection and decontamination strategy using laser scanning microscopy...
January 20, 2018: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/29353215/sparks-fly-between-ascorbic-acid-and-iron-based-nanozymes-a-study-on-prussian-blue-nanoparticles
#4
Wei Zhang, Yang Wu, Hai-Jiao Dong, Jun-Jie Yin, Hui Zhang, Hao-An Wu, Li-Na Song, Yu Chong, Zhuo-Xuan Li, Ning Gu, Yu Zhang
Herein we reported Prussian blue nanoparticles (PBNPs) possess ascorbic acid oxidase (AAO)- and ascorbic acid peroxidase (APOD)-like activities, which suppressed the formation of harmful H2O2 and finally inhibited the anti-cancer efficiency of ascorbic acid (AA). This newly revealed correlation between iron and AA could provide new insight for the studies of nanozymes and free radical biology.
January 11, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29353164/a-phase-ii-study-of-nab-paclitaxel-in-combination-with-ramucirumab-in-patients-with-previously-treated-advanced-gastric-cancer
#5
Hideaki Bando, Hideki Shimodaira, Kazumasa Fujitani, Atsuo Takashima, Kensei Yamaguchi, Norisuke Nakayama, Takehiro Takahashi, Eiji Oki, Mizutomo Azuma, Tomohiro Nishina, Shuichi Hironaka, Yoshito Komatsu, Kohei Shitara
BACKGROUND: Nanoparticle albumin-bound (nab)-paclitaxel was developed to improve paclitaxel solubility and does not need premedication to avoid infusion-related reactions associated with solvent-based (sb)-paclitaxel. We conducted a phase II trial to investigate the efficacy and safety of nab-paclitaxel plus ramucirumab combination therapy for previously treated advanced gastric cancer. PATIENTS AND METHODS: Patients with unresectable advanced gastric cancer refractory to first-line chemotherapy were administered nab-paclitaxel 100 mg/m2 intravenously on days 1, 8 and 15, plus ramucirumab 8 mg/kg intravenously on days 1 and 15 of a 28-day cycle...
January 17, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29353113/cadmium-immobilization-in-river-sediment-using-stabilized-nanoscale-zero-valent-iron-with-enhanced-transport-by-polysaccharide-coating
#6
Danlian Huang, Zhengxun Hu, Zhiwei Peng, Guangming Zeng, Guomin Chen, Chen Zhang, Min Cheng, Jia Wan, Xi Wang, Xiang Qin
Proper management of metal-contaminated sediment plays a key role in sediment recovery and reuse. This study synthesized two kinds of stabilized nanoscale zero-valent iron (nZVI) with starch (S-nZVI) and carboxymethyl cellulose (C-nZVI) for the in situ immobilization of Cd(II) in river sediment and investigated their transport in porous media. Experimental data showed that when the sediment sample was treated with C-nZVI for 56 days at a dosage ranging from 5 to 10 mg/g-sediment as Fe0, the TCLP (toxicity characteristic leaching procedure) leachability of Cd(II) in the sediment decreased by 93...
January 17, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29353017/ph-triggered-surface-charge-reversal-nanoparticles-alleviate-experimental-murine-colitis-via-selective-accumulation-in-inflamed-colon-regions
#7
Muhammad Naeem, Murtada A Oshi, Jihyun Kim, Juho Lee, Jiafu Cao, Hasan Nurhasni, Eunok Im, Yunjin Jung, Jin-Wook Yoo
In this study, we developed pH-triggered surface charge-reversal lipid nanoparticles (LNPs), loaded with budesonide, which could precisely deliver the drug to inflamed colon segments for the treatment of ulcerative colitis. Polyethyleneimine (PEI) was used to render LNPs cationic (PEI-LNPs), and Eudragit® S100 (ES) was coated on PEI-LNPs to obtain pH-triggered charge-reversal LNPs (ES-PEI-LNPs). ES coating avoided a burst drug release under acidic conditions mimicking the stomach and early small intestine environments and showed a sustained release in the colon...
January 15, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29353012/fabrication-of-poly-ethylene-glycol-coated-mesoporous-nanocomposite-zno-fe2o3-for-methotrexate-delivery-an-integrated-nanoplatform-for-dual-mode-cancer-therapy
#8
Azam S Alavi, Azadeh Meshkini
Although chemotherapy is an effective strategy for treatment of tumor cells, the non-specific distribution of chemotherapy drugs and their poor aqueous solubility result in impaired treatment and cause serious side effects in patients. In this study, mesoporous ZnO@Fe2O3 nanocomposite was fabricated and used as a platform for drug delivery. ZnO@Fe2O3 nanocomposite showed a high capacity for the adsorption of chemotherapy drug, methotrexate (MTX). Drug-loaded nanoparticle was coated with poly(ethylene glycol) (PEG), leading to the enhanced colloidal stability and good cytocompatibility...
January 15, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29352947/novel-organic-inorganic-hybrid-flower-like-structure-of-selenium-nanoparticles-stabilized-by-pullulan-derivatives
#9
Punnida Nonsuwan, Songchan Puthong, Tanapat Palaga, Nongnuj Muangsin
We proudly present the first organic/inorganic hybrid pullulan/SeNPs hybrid microflower material obtained using a simple and bio-inspired strategy. The chemical structures of pullulan, folic acid decorated cationic pullulan (FA-CP) were designed for stabilizing selenium nanoparticles (SeNPs). SeNPs stabilized by FA-CP hybrid microflowers were observed after the addition of a cysteine hydrochloride solution into the solution mixture of Na2SeO3 and FA-CP. We suggested that the concentrations of cysteine and FA-CP were the key factors for the formation of flower-like structure...
March 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29352946/redox-enzyme-sensitive-chondroitin-sulfate-based-self-assembled-nanoparticles-loading-docetaxel-for-the-inhibition-of-metastasis-and-growth-of-melanoma
#10
Mengrui Liu, Hongliang Du, Abdur Rauf Khan, Jianbo Ji, Aihua Yu, Guangxi Zhai
In this report, redox/enzyme responsive chondroitin sulfate-ss-deoxycholic acid (CSCD) conjugates were synthesized using cystamine as the linkage which could self-assemble to form self-assembled nanoparticles (175.6 + 5.2 nm) in the aqueous environment. Docetaxel (DTX) was loaded in nanoparticles with desired loading efficiency for the inhibition of tumor growth and metastasis of melanoma. Interestingly, nanoparticles were demonstrated to respond to hyaluronidase-1 (Hyal-1) which could degrade chondroitin sulfate (CS) backbones...
March 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29352940/pegylated-chitosan-nanoparticles-with-embedded-bismuth-sulfide-for-dual-wavelength-fluorescent-imaging-and-photothermal-therapy
#11
Ke Wang, Jialang Zhuang, Yubing Liu, Maosheng Xu, Jingyuan Zhuang, Zuanguang Chen, Yen Wei, Yuanqing Zhang
It is of great significance to construct multifunctional nanosystems for simultaneous imaging and therapy of cancer cells. Herein, PEGylated chitosan nanoparticles with embedded bismuth sulfide were facilely fabricated via reverse-microemulsion method for fluorescent imaging and photothermal therapy of HepG2 cells. The obtained BSA-Bi2S3-CG-PEG nanospheres revealed dual-wavelength fluorescence, which were spectrally isolated from the bioautofluorescence. Moreover, they demonstrated remarkable photothermal conversion efficiency and stability...
March 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29352920/biomass-based-magnetic-fluorescent-nanoparticles-one-step-scalable-synthesis-application-as-drug-carriers-and-mechanism-study
#12
Lei Li, Feijun Wang, Ziqiang Shao
A biomass-based magnetic fluorescent nanoparticle (MFNPs) was successively in situ synthesized via a one-step high-gravity approach, which constructed by a magnetic core of Fe3O4 nanoparticles, the fluorescent marker of carbon dots (CDs), and shells of chitosan (CS). The obtained MFNPs had a 10 nm average diameter and narrow particle size distribution, low cytotoxicity, superior fluorescent emission and superparamagnetic properties. The encapsulating and release 5-fluorouracil experiments confirmed that the introduction of CS/CDs effectively improved the drug loading capacity...
March 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29352900/evaluation-of-nisin-loaded-chitosan-monomethyl-fumaric-acid-nanoparticles-as-a-direct-food-additive
#13
Imran Khan, Charles Nkufi Tango, Sumaira Miskeen, Deog-Hwan Oh
Nisin-loaded chitosan-monomethyl fumaric acid (CM-N) nanoparticles were evaluated as a novel, direct food additive. Chitosan (CS) was modified with monomethyl fumaric acid (MFA) in the presence of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC). CS-loaded nisin (CS-N) and CM-N nanoparticles were produced through ionic interactions between the positive amino group of CS and CS-MFA and negative tripolyphosphate ions. The resultant materials were characterized by TNBS assay, X-ray diffraction, Fourier-transform infrared spectroscopy, scanning electron microscopy, thermogravimetric analysis, and zeta potential analysis...
March 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29352894/a-novel-wound-dressing-based-on-a-konjac-glucomannan-silver-nanoparticle-composite-sponge-effectively-kills-bacteria-and-accelerates-wound-healing
#14
Honglei Chen, Guangqian Lan, Luoxiao Ran, Yang Xiao, Kun Yu, Bitao Lu, Fangying Dai, Dayang Wu, Fei Lu
A novel Konjac glucomannan/silver nanoparticle (KGM/AgNP) composite sponge was successfully prepared via a simple 2-step method for biomedical applications as wound-healing materials. First, AgNPs were prepared with green deoxidizer egg white. Then, KGM powder was added to the AgNP solution and stirred vigorously, and the composite sponge was obtained by freeze-drying. The KGM/AgNP composite sponge showed excellent water absorption and water retention, and considerable mechanical properties. KGM/AgNP composite sponges displayed good antibacterial activity against test microorganisms...
March 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29352891/efficient-gene-delivery-by-oligochitosan-conjugated-serum-albumin-facile-synthesis-polyplex-stability-and-transfection
#15
Monika Kumari, Chi-Hsien Liu, Wei-Chi Wu
Chitosan and its derivatives have shown to be potential gene carriers with biocompatiblility and safety. However, their practical delivery is far from being ideal because of the low transfection efficiency. The present work describes the potential of a natural protein, bovine serum albumin (BSA), conjugated with a natural oligosaccharide, oligochitosan (OC), as a considerable promising approach for a safe and efficient non-viral gene delivery vector. The FTIR spectra proved the effective conjugation of BSA with OC through covalent bond...
March 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29352888/production-of-cellulose-nanoparticles-from-blue-agave-waste-treated-with-environmentally-friendly-processes
#16
Eduardo Robles, Javier Fernández-Rodríguez, Ananda M Barbosa, Oihana Gordobil, Neftali L V Carreño, Jalel Labidi
Tequila elaboration leaves two main byproducts that are undervalued (bagasse and leaves). Organosolv pulping and Total Chlorine Free bleaching were integrated to obtain cellulose fibers from agricultural waste which consisted of blue agave bagasse and leaf fibers; together they represent a green process which valorizes biomass waste. The obtained celluloses were characterized by FT-IR, colorimetry, and SEM and their extraction yields were evaluated. These celluloses were used to produce cellulose nanocrystals and cellulose nanofibers...
March 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29352886/aldehyde-functionalized-chitosan-montmorillonite-films-as-dynamically-assembled-switchable-chemical-release-bioplastics
#17
Jamal Chabbi, Oumayma Jennah, Nadia Katir, Mohamed Lahcini, Mosto Bousmina, Abdelkrim El Kadib
Temporal release of synergistic and/or complementary chemicals (e.g.: drugs) is recognized as extremely challenging because of their frequently intertwined kinetic delivery and presently, straightforward concepts enabling to circumvent this bottleneck are missing in the open literature. In this framework, we report herein on aldehyde-functionalized, transparent and flexible chitosan-montmorillonite hybrid films that act as a new generation of eco-friendly, controlled-chemical release bioplastics. These dynamically-assembled nanomaterials are designed by a ternary assembly from biowaste derived chitin biopolymer, aromatic aldehydes and layered clay nanoparticles...
March 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29352869/positively-charged-gold-nanoparticles-capped-with-folate-quaternary-chitosan-synthesis-cytotoxicity-and-uptake-by-cancer-cells
#18
Hui-Ju Yen, Yen-An Young, Tsung-Neng Tsai, Kuang-Ming Cheng, Xin-An Chen, Ying-Chuan Chen, Cheng-Cheung Chen, Jenn-Jong Young, Po-da Hong
In this study, we synthesized various quaternary chitosan derivatives and used them to stabilize gold nanoparticles (AuNPs). These chitosan derivatives comprised N-(2-hydroxy)propyl-3-trimethylammonium chitosan chloride (HTCC), folate-HTCC, galactosyl-HTCC, and their fluorescein isothiocyanate-conjugated derivatives. Various positively surface-charged AuNPs were prepared under alkaline conditions using glucose as a reducing agent in the presence of the HTCC derivatives (HTCCs). The effects of the concentration of NaOH, glucose, and HTCCs on the particles size, zeta potential, and stability were studied in detail...
March 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29352793/theoretical-study-of-tetrahedral-site-occupation-by-hydrogen-in-pd-nanoparticles
#19
Takayoshi Ishimoto, Michihisa Koyama
To understand the enhanced effects and new hydrogen absorption properties of metal nanoparticles, we theoretically investigated the hydrogen absorption in Pd nanoparticles, adopting the Pd405 model of ca. 2.5 nm by using density functional theory. Pd405 showed inhomogeneous geometric features, especially near the surface region. The hydrogen absorptions in octahedral (O) and tetrahedral (T) sites near the core region were stable and unstable, respectively, similar to the Pd bulk. We clearly demonstrated the possibility of hydrogen absorption in T sites near the surface of Pd405...
January 21, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29352735/s-nitrosated-poly-propylene-sulfide-nanoparticles-for-enhanced-nitric-oxide-delivery-to-lymphatic-tissues
#20
Alex Schudel, Lauren F Sestito, Susan N Thomas
Nitric oxide (NO) is a therapeutic implicated for the treatment of diseases affecting lymphatic tissues, which range from infectious and cardiovascular diseases to cancer. Existing technologies available for NO therapy, however, provide poor bioactivity within lymphatic tissues. In this work, we address this technology gap with a NO encapsulation and delivery strategy leveraging the formation of S-nitrosothiols on lymphatic-targeting Pluronic-stabilized, poly(propylene sulfide)-core nanoparticles (SNO-NP). We evaluated in vivo the lymphatic versus systemic delivery of NO resulting from intradermal administration of SNO-NP benchmarked against a commonly used, commercially available small molecule S-nitrosothiol NO donor, examined signs of toxicity systemically as well as localized to the site of injection, and investigated SNO effects on lymphatic transport and NP uptake by LN-resident cells...
January 20, 2018: Journal of Biomedical Materials Research. Part A
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