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Wei-Hai Chen, Guo-Feng Luo, Wen-Xiu Qiu, Qi Lei, Li-Han Liu, Shi-Bo Wang, Xian-Zheng Zhang
Supramolecular photosensitizers (supraPSs) have emerged as effective photodynamic therapy (PDT) agents. Here, we propose the assembling capacity of supraPSs as a new strategy to construct theranostic nanoplatform with versatile functions aming at high-performance tumor therapy. By coating tirapazamine (TPZ)-loaded mesoporous silica nanoparticles (MSNs) with layer-by-layer (LbL) assembled multilayer, the versatile nanoplatform (TPZ@MCMSN-Gd(3+)) was obtained with the formation of supraPSs via host-guest interaction and the chelation with paramagnetic Gd(3+)...
December 1, 2016: Biomaterials
R Brad Jones, Stephanie Mueller, Sudha Kumari, Vlad Vrbanac, Shy Genel, Andrew M Tager, Todd M Allen, Bruce D Walker, Darrell J Irvine
Cytotoxic T-Lymphocytes (CTLs) kill pathogen-infected or transformed cells following interaction of their T-cell receptors (TCRs) with foreign (e.g. virus-derived) peptides bound to MHC-I molecules on the target cell. TCR binding triggers CTLs to secrete perforin, which forms pores in the target cell membrane, promoting target death. Here, we show that by conjugating drug-loaded lipid nanoparticles to the surface of CTLs, their lytic machinery can be co-opted to lyse the cell-bound drug carrier, providing triggered release of drug cargo upon target cell recognition...
November 25, 2016: Biomaterials
Sepideh Vahabi, Ali Eatemadi
The systemic administration of opioids leads to potentially severe and undesirable and side effects like sedation and drowsiness, vomiting and nausea, allergies, respiratory depression, and neutrophil dysfunction. The application of nanotechnology in medical field has drawn a great attention in recent times. Several treatments available are tedious and expensive. Application of nanotechnology brings about faster cure and cost effectiveness. Nanoliposomes are one of the widely used names for nanoparticles used in medicine...
December 6, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Juan M Asensio, Simon Tricard, Yannick Coppel, Román Andrés, Bruno Chaudret, Ernesto de Jesús
The coordination of N-heterocyclic carbene (NHC) ligands to the surface of 3.7 nm palladium nanoparticles (PdNPs) can be unambiguously established by observation of Knight shift (KS) in the (13) C resonance of the carbenic carbon. In order to validate this coordination, PdNPs with sizes ranging from 1.3 to 4.8 nm were prepared by thermal decomposition or reduction with CO of a dimethyl NHC Pd(II) complex. NMR studies after (13) CO adsorption established that the KS shifts the (13) C resonances of the chemisorbed molecules several hundreds of ppm to high frequencies only when the particle exceeds a critical size of around 2 nm...
December 9, 2016: Angewandte Chemie
Wenpei Fan, Nan Lu, Peng Huang, Yi Liu, Zhen Yang, Sheng Wang, Guocan Yu, Yijing Liu, Junkai Hu, Qianjun He, Junle Qu, Tianfu Wang, Xiaoyuan Chen
Glucose is a key energy supplier and nutrient for tumor growth. Herein, inspired by the glucose oxidase (GOx)-assisted conversion of glucose into gluconic acid and toxic H2 O2 , a novel treatment paradigm of starving-like therapy is developed for significant tumor-killing effects, more effective than conventional starving therapy by only cutting off the energy supply. Furthermore, the generated acidic H2 O2 can oxidize l-Arginine (l-Arg) into NO for enhanced gas therapy. By using hollow mesoporous organosilica nanoparticle (HMON) as a biocompatible/biodegradable nanocarrier for the co-delivery of GOx and l-Arg, a novel glucose-responsive nanomedicine (l-Arg-HMON-GOx) has been for the first time constructed for synergistic cancer starving-like/gas therapy without the need of external excitation, which yields a remarkable H2 O2 -NO cooperative anticancer effect with minimal adverse effect...
December 9, 2016: Angewandte Chemie
Nisha Shabnam, P Sharmila, Hyunook Kim, P Pardha-Saradhi
The unique potential of chloroplasts/thylakoids to harness light energy to transport electrons from H2O to various entities was exploited for reduction of Ag+ to generate nanoparticles (NPs). Spinach thylakoids/chloroplasts turned AgNO3 solutions brown in light, but not in dark. Besides showing Ag-NPs specific surface plasmon resonance band, these brown solutions showed presence of 5-30 nm crystalline NPs composed of Ag. Powder X-ray diffraction (PXRD) analysis revealed that Ag-NPs were biphasic composed of face-centered cubic Ag0 and cubic Ag2O...
2016: PloS One
Tushar D Rane, Andrea M Armani
Nanomaterials can be synthesized from a wide range of material systems in numerous morphologies, creating an extremely diverse portfolio. As result of this tunability, these materials are emerging as a new class of nanotherapeutics and imaging agents. One particularly interesting nanomaterial is the gold nanoparticle. Due to its inherent biocompatibility and tunable photothermal behavior, it has made a rapid transition from the lab setting to in vivo testing. In most nanotherapeutic applications, the efficacy of the agent is directly related to the target of interest...
2016: PloS One
Na Xing, Xiaoxiao Guan, Bin An, Beibei Cui, Zengguo Wang, Xiaoya Wang, Xiujuan Zhang, Qian Du, Xiaomin Zhao, Yong Huang, Dewen Tong
Porcine epidemic diarrhea virus (PEDV) is the main causative agent of porcine diarrhea, which has resulted in devastating damage to swine industry and become a perplexed global problem. PEDV infection causes lesions and clinical symptoms, and infected pigs often succumb to severe dehydration. If there is not a timely and effective method to control its infection, PEDV will spread rapidly across the whole swine farm. Therefore, preclinical identification of PEDV is of great significance for preventing the outbreak and spread of this disease...
2016: PloS One
F Porcaro, Y Miao, R Kota, J B Haun, G Polzonetti, C Battocchio, E Gratton
In this work, we report the synthesis and biophysical studies carried out on a new kind of biocompatible and very stable gold nanoparticle (GNP) stabilized with glucose through a PEG linker (AuNP-PEG-Glu). The synthetic path was optimized to obtain nanoparticles of controlled sizes. ζ-potential and dynamic light scattering measurements allowed assessment of the nanodimension, dispersity, surface charge, and stability of our GNPs. Confocal microscopy demonstrated qualitatively that glucose molecules are successfully bonded to GNP surfaces...
December 9, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
Nitya Sai Reddy Satyavolu, Li Huey Tan, Yi Lu
Recent reports have shown that different DNA sequences can mediate the control of shapes and surface properties of nanoparticles. However, all previous studies have involved only monometallic particles, most of which were gold nanoparticles. Controlling the shape of bimetallic nanoparticles is more challenging, and there is little research into the use of DNA-based ligands for their morphological control. We report the DNA-templated synthesis of Pd-Au bimetallic nanoparticles starting from palladium nanocube seeds...
December 9, 2016: Journal of the American Chemical Society
Jing Xue, Guangting Han, Wanneng Ye, Yutao Sang, Hongliang Li, Peizhi Guo, X S Zhao
Two types of PdCu2 nanoparticles were prepared through one-pot synthesis and a two-step reducing process, named as PdCu2-1 and PdCu2-2, respectively. The morphology and structure of as-prepared samples were investigated by transmission electron microscopy, high-resolution transmission electron microscopy, X-ray diffraction, X-ray photoelectron spectroscopy, and inductively coupled plasma-optical emission spectrometry. Results showed that more Pd atoms were buried in the inside of PdCu2-1, whereas more available Pd sites were distributed on the surface of PdCu2-2...
December 9, 2016: ACS Applied Materials & Interfaces
Jianyuan Zhang, Peter J Santos, Paul A Gabrys, Sangho Lee, Caroline Liu, Robert J Macfarlane
The physical characteristics of composite materials are dictated by both the chemical composition and spatial configuration of each constituent phase. A major challenge in nanoparticle-based composites is developing methods to precisely dictate particle positions at the nanometer length scale, as this would allow complete control over nanocomposite structure-property relationships. In this work, we present a new class of building blocks called nanocomposite tectons (NCTs), which consist of inorganic nanoparticles grafted with a dense layer of polymer chains that terminate in molecular recognition units capable of programmed supramolecular bonding...
December 9, 2016: Journal of the American Chemical Society
Patrícia Petromilli Nordi Sasso Garcia, Mariana Florian Bell Cardia, Renata Serignoli Francisconi, Lívia Nordi Dovigo, Denise Madalena Palomari Spolidório, Alessandra Nara de Souza Rastelli, Ana Carolina Botta
This study evaluated the antibacterial activity of zinc oxide nanoparticles incorporated into self-cured glass ionomer cement (GIC) and light-cured resin-reinforced GIC on Streptococcus mutans biofilm. The GICs, Fuji II (GC America) and Fuji II LC (GC America), were incorporated with nanoparticles at concentrations of 0%, 1%, and 2% by weight, and the biofilm maturation time was one and seven days. Circular specimens of each GIC type were prepared. The antibacterial activity was evaluated by determining the number of colony forming units of S...
December 9, 2016: Microscopy Research and Technique
Yakun Tang, Lang Liu, Hongyang Zhao, Shasha Gao, Yan Lv, Lingbing Kong, Junhong Ma, Dianzeng Jia
Compared with Li4Ti5O12, LiCrTiO4 with the same spinel structure exhibits superior conductivity and Li(+) diffusion properties. However, there has been no extensive study on LiCrTiO4 as an anode material in lithium ion batteries, due to its pulverization, loss of electrical contact, and particle aggregation. A unique architecture based on hybrid porous CNTs embedding ultrasmall LiCrTiO4 nanoparticles (6 ± 2 nm) was designed by using a facile sol-gel process combined with subsequent heat treatment. As an anode for lithium ion batteries, due to the absence of the aforementioned problems, the electrode exhibited high reversible capacity, excellent rate capability and superior long-term cycling stability at high current densities...
December 9, 2016: Chemical Communications: Chem Comm
Jingchao Li, Hongli Mao, Naoki Kawazoe, Guoping Chen
Multifunctional nanoparticles (NPs) have been widely used in biomedical applications because of their versatile properties. The properties of NPs should be well designed and controlled according to various applications because they may directly affect the functions and performances of NPs in biological systems. Cellular uptake is a prerequisite for the success of NP-based biomedical applications. However, the internalized NPs inside cells may have some adverse effects. Therefore, the interactions between NPs and cells should be thoroughly investigated and elucidated...
December 9, 2016: Biomaterials Science
Yuske Kobayashi, Ralf Hauptmann, Harald Kratz, Monika Ebert, Susanne Wagner, Matthias Taupitz
BACKGROUND: Pharmacokinetic studies and histological detection of superparamagnetic iron oxide nanoparticles (SPIO) in biomedical research are limited due to a high iron background especially in pathological tissues. OBJECTIVE: The suitability of doping the iron oxide cores of SPIO with europium (Eu) was tested for improved histologic detection and for quantitative analysis without changing their properties as probes for magnetic resonance imaging (MRI). A special variant of SPIO, so called very small superparamagnetic iron oxide nanoparticles (VSOP), was used for this approach...
December 2, 2016: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
José das Neves, Bruno Sarmento
No abstract text is available yet for this article.
December 9, 2016: Expert Opinion on Drug Delivery
Lauriane Alison, Patrick A Rühs, Elena Tervoort, Alexandra Teleki, Michele Zanini, Lucio Isa, André R Studart
Edible solid particles constitute an attractive alternative to surfactants as stabilizers of food-grade emulsions for products requiring a long-term shelf life. Here, we report on a new approach to stabilize edible emulsions using silica nanoparticles modified by noncovalently bound chitosan oligomers. Electrostatic modification with chitosan increases the hydrophobicity of the silica nanoparticles and favors their adsorption at the oil-water interface. The interfacial adsorption of the chitosan-modified silica particles enables the preparation of oil-in-water emulsions with small droplet sizes of a few micrometers through high-pressure homogenization...
December 9, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
Tom Kollek, Daniel Wurmbrand, Susanne T Birkhold, Eugen Zimmermann, Julian Kalb, Lukas Schmidt-Mende, Sebastian Polarz
Particle-based semiconductor materials are promising constituents of future technologies. They are described by unique features resulting from the combination of discrete nanoparticle characteristics and the emergence of cooperative phenomena based on long-range interaction within their superstructure. (Nano)particles of outstanding quality with regards to size and shape can be prepared via colloidal synthesis using appropriate capping agents. The classical capping agents are electrically insulating, which impedes particle-particle electronic communication...
December 9, 2016: ACS Applied Materials & Interfaces
Sirshendu Ghosh, Manas Saha, Sumana Paul, S K De
The synthesis of different anisotropic shaped (eight different shapes) Sn(4+) doped CdO (Sn:CdO) colloidal nanocrystals (NCs) by precise tuning of precursor reactivity and proper choice of capping agent is reported. In all these systems, formation of Sn:CdO quantum dots (QDs) of 2-3 nm is identified at very early stage of reaction. The colloidally stable QDs act as a continuous source for the formation of primary nanoparticles that can be transformed selectively into specific type of nanoparticle morphology...
December 9, 2016: Small
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