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Gyanendra Kumar

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https://www.readbyqxmd.com/read/29302549/validity-of-indian-diabetes-risk-score-and-its-association-with-body-mass-index-and-glycosylated-hemoglobin-for-screening-of-diabetes-in-and-around-areas-of-lucknow
#1
Mohammad Mustufa Khan, Gyanendra Kumar Sonkar, Roshan Alam, Sudhir Mehrotra, M Salman Khan, Ajay Kumar, Satyendra Kumar Sonkar
Objectives: The present study aimed to assess the validity of Indian Diabetes Risk Score (IDRS) and its association with body mass index (BMI) and glycosylated hemoglobin (HbA1c) for screening of diabetes and obesity. Methodology: A cross-sectional study was designed, and samples were randomly enrolled from Lucknow and its adjoining areas. Totally, 405 subjects were included in the study. We used diabetes risk factors (age, waist circumference, physical activity, and family history of diabetes) for screening of diabetes and abdominal obesity (AO) and BMI for screening of general obesity...
April 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29231735/a-novel-folate-binding-protein-in-arabidopsis-expressed-during-salicylic-acid-induced-folate-accumulation
#2
Bijesh Puthusseri, Peethambaran Divya, Veeresh Lokesh, Gyanendra Kumar, Mohammed Azharuddin Savanur, Bhagyalakshmi Neelwarne
Increasing the quantity of natural folates in plant foods is recently gaining significant interest, owing to their acute deficiencies in various populations. This study observed that foliar salicylic acid treatment enhanced the accumulation of folates in Arabidopsis, which correlated with the increase in a folate binding protein (FBP) and the expression of mRNA of a putative folate binding protein At5G27830. A protein band corresponding to ~43 kDa was observed after resolving the affinity-purified protein on SDS-PAGE, and the partial amino acid sequence indicated that the protein is indeed At5G27830...
December 12, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29215062/protein-structure-assisted-optimization-of-4-5-dihydroxypyrimidine-6-carboxamide-inhibitors-of-influenza-virus-endonuclease
#3
Diane Beylkin, Gyanendra Kumar, Wei Zhou, Jaehyeon Park, Trushar Jeevan, Chandraiah Lagisetti, Rhodri Harfoot, Richard J Webby, Stephen W White, Thomas R Webb
Influenza is a serious hazard to human health that causes hundreds of thousands of deaths annually. Though vaccines and current therapeutics can blunt some of the perilous impact of this viral infection, new treatments are needed due to the constantly evolving nature of this virus. Recently, our growing understanding of an essential influenza viral protein, PA, has led to the development of focused libraries of new small molecules that specifically target the active site of the PA influenza endonuclease, which we report here...
December 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29118496/visual-outcome-and-complications-of-various-techniques-of-secondary-intraocular-lens
#4
Santosh Kumar, Satyaprakash Singh, Gyanendra Singh, Nilesh S Rajwade, Sushank A Bhalerao, Vinod Singh
BACKGROUND/AIMS: The purpose of this study was to compare and evaluate the visual outcome and complications of various techniques of secondary intraocular lens (IOL) (i.e., anterior chamber IOL [ACIOL], suture-fixated posterior chamber IOL [PCIOL], and glue-fixated PCIOL). STUDY DESIGN AND SETTING: This was a randomized, prospective, interventional, comparative, clinical trial study. SUBJECTS AND METHODS: Patients of either sex having aphakia and lacking posterior capsular support were included in the study, and patients having corneal or scleral pathology, optic atrophy, uncontrolled glaucoma, retinal detachment, and other retinal pathology were excluded from the study...
September 2017: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/29037729/evaluation-of-folate-binding-proteins-and-stability-of-folates-in-plant-foliages
#5
Bijesh Puthusseri, Peethambaran Divya, Lokesh Veeresh, Gyanendra Kumar, Bhagyalakshmi Neelwarne
The present study reports the presence of folate binding proteins (FBPs) in the plants, coriander and Arabidopsis, and their contributions toward folate enhancement. After observing that salicylic acid (SA) enhanced the accumulation of folates in coriander, a study was conducted in Arabidopsis, where twofold increase in folates occurred in foliage upon SA treatment. For obtaining insights into genes involved in SA-induced folate accumulation, microarray data of responsive genes in Arabidopsis were screened...
March 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28979274/biochemical-defense-response-characterizing-the-plasticity-of-source-and-sink-in-spring-wheat-under-terminal-heat-stress
#6
Ranjeet R Kumar, Suneha Goswami, Mohammed Shamim, Upama Mishra, Monika Jain, Khushboo Singh, Jyoti P Singh, Kavita Dubey, Shweta Singh, Gyanendra K Rai, Gyanendra P Singh, Himanshu Pathak, Viswanathan Chinnusamy, Shelly Praveen
Wheat is highly prone to terminal heat stress (HS) under late-sown conditions. Delayed- sowing is one of the preferred methods to screen the genotypes for thermotolerance under open field conditions. We investigated the effect of terminal HS on the thermotolerance of four popular genotypes of wheat i.e. WR544, HD2967, HD2932, and HD2285 under field condition. We observed significant variations in the biochemical parameters like protein content, antioxidant activity, proline and total reducing sugar content in leaf, stem, and spike under normal (26 ± 2°C) and terminal HS (36 ± 2°C) conditions...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28942841/exploitation-of-agro-climatic-environment-for-selection-of-1-aminocyclopropane-1-carboxylic-acid-acc-deaminase-producing-salt-tolerant-indigenous-plant-growth-promoting-rhizobacteria
#7
Sankalp Misra, Vijay Kant Dixit, Mohammad Haneef Khan, Shashank Kumar Mishra, Gyanendra Dviwedi, Sumit Yadav, Alok Lehri, Puneet Singh Chauhan
A comprehensive survey for 09 agro-climatic zones of Uttar Pradesh, India was conducted to isolate and characterize salt tolerant 1-aminocyclopropane-1-carboxylic acid (ACC) deaminase possessing plant growth promoting (PGP) rhizobacteria for salt stress amelioration in rice. Here, we have isolated 1125 bacteria having the ability to tolerate 1M NaCl and out of those, 560 were screened for utilizing ACC as sole nitrogen source. 560 isolates were subjected for bacteria coated seed germination assay under 100mM salt (NaCl) stress resulting to 77 isolates which were further evaluated for seed germination assay, PGP and abiotic stress tolerance ability in vitro...
December 2017: Microbiological Research
https://www.readbyqxmd.com/read/28890621/soft-tissue-applications-of-er-cr-ysgg-laser-in-pediatric-dentistry
#8
Gyanendra Kumar, Ferah Rehman, Vivek Chaturvedy
Soft tissue laser, such as diode and Nd:YAG lasers were initially used in soft tissue lesions because of its increased success rate. It was because of the fact that these lasers were well-absorbed by chromophores, such as hemoglobin and melanin which are found abundant in the oral mucosa. The introduction of erbium family in 1990 comprising the Er:YAG and Er,Cr:YSGG lasers made the hard tissue laser a boon for dentistry. Erbium, chromium-doped yttrium, scandium, gallium and garnet (Er,Cr:YSGG) was introduced in 1997 for the surgical needs of clinical dentistry in general practice...
April 2017: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28843678/supplementation-of-vitamin-e-selenium-and-increased-energy-allowance-mitigates-the-transition-stress-and-improves-postpartum-reproductive-performance-in-the-crossbred-cow
#9
Amit Khatti, Sanjeev Mehrotra, Pankaj Kumar Patel, Gyanendra Singh, Vijai Prakash Maurya, Ajit Singh Mahla, Ravjibhai Karshanbhai Chaudhari, Gautam Kumar Das, Mithilesh Singh, Mihir Sarkar, Harendra Kumar, Narayanan Krishnaswamy
Dairy cow undergoes tremendous physiological challenges during the transition period leading to negative energy balance (NEBAL), impaired immunity and oxidative stress that ultimately compromises the postpartum fertility. Accordingly, we investigated the effects of antioxidant supplementation and increased energy allowance on transition stress and fertility of crossbred cow. Advanced pregnant crossbred cows (n = 26) of 2-4 parity and lactation potential of >10 L/day were divided into two equal groups (n = 13 cows/group)...
August 16, 2017: Theriogenology
https://www.readbyqxmd.com/read/28793327/qtl-mapping-for-nine-drought-responsive-agronomic-traits-in-bread-wheat-under-irrigated-and-rain-fed-environments
#10
Vijay Gahlaut, Vandana Jaiswal, Bhudeva S Tyagi, Gyanendra Singh, Sindhu Sareen, Harindra S Balyan, Pushpendra Kumar Gupta
In bread wheat, QTL interval mapping was conducted for nine important drought responsive agronomic traits. For this purpose, a doubled haploid (DH) mapping population derived from Kukri/Excalibur was grown over three years at four separate locations in India, both under irrigated and rain-fed environments. Single locus analysis using composite interval mapping (CIM) allowed detection of 98 QTL, which included 66 QTL for nine individual agronomic traits and 32 QTL, which affected drought sensitivity index (DSI) for the same nine traits...
2017: PloS One
https://www.readbyqxmd.com/read/28789682/additional-burden-of-asymptomatic-and-sub-patent-malaria-infections-during-low-transmission-season-in-forested-tribal-villages-in-chhattisgarh-india
#11
Mehul Kumar Chourasia, Kamaraju Raghavendra, Rajendra M Bhatt, Dipak Kumar Swain, Hemraj M Meshram, Jayant K Meshram, Shrity Suman, Vinita Dubey, Gyanendra Singh, Kona Madhavinadha Prasad, Immo Kleinschmidt
BACKGROUND: The burden of sub-patent malaria is difficult to recognize in low endemic areas due to limitation of diagnostic tools, and techniques. Polymerase chain reaction (PCR), a molecular based technique, is one of the key methods for detection of low parasite density infections. The study objective was to assess the additional burden of asymptomatic and sub-patent malaria infection among tribal populations inhabiting three endemic villages in Keshkal sub-district, Chhattisgarh, India...
August 8, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28776223/differential-expression-of-micrornas-associated-with-thermal-stress-in-frieswal-bos-taurus-x-bos-indicus-crossbred-dairy-cattle
#12
Gyanendra Singh Sengar, Rajib Deb, Umesh Singh, T V Raja, Rajiv Kant, Basavraj Sajjanar, Rani Alex, R R Alyethodi, Ashish Kumar, Sushil Kumar, Rani Singh, Subhash J Jakhesara, C G Joshi
Environmental temperature is one of the important abiotic factors that influence the normal physiological function and productive performance of dairy cattle. Temperature stress evokes complex responses that are essential for safeguarding of cellular integrity and animal health. Post-transcriptional regulation of gene expression by miRNA plays a key role cellular stress responses. The present study investigated the differential expression of miRNA in Frieswal (Holstein Friesian × Sahiwal) crossbred dairy cattle that are distinctly adapted to environmental temperature stress as they were evolved by using the temperate dairy breed Holstein Friesian...
August 3, 2017: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/28765674/a-comparative-evaluation-of-retention-of-pit-and-fissure-sealants-placed-with-conventional-acid-etching-and-er-cr-ysgg-laser-etching-a-randomised-controlled-trial
#13
Gyanendra Kumar, Jatinder Kaur Dhillon, Ferah Rehman
Aim: The aim of this study was to compare the retention rates of sealant placed either with conventional acid etching or Er,Cr:YSGG laser pretreatment of enamel surface. Materials and methods: This is a prospective, single blind randomised controlled clinical trial enrolling 200 permanent first molars in 50 patients, aged 6-12 years for sealant placement. Study followed split mouth design where each side of the arch was randomly allocated to the two treatment group. Group A(Acid etch group): 37 % phosphoric acid (Scotchbond, 3M ESPE, Seefeld, Germany) was applied for 15 seconds, rinsed with water for 20 seconds and then air-dried using air spray...
December 30, 2016: Laser Therapy
https://www.readbyqxmd.com/read/28748877/vitamin-d-levels-and-other-biochemical-parameters-of-mineral-bone-disorders-and-their-association-with-diastolic-dysfunction-and-left-ventricular-mass-in-young-nondiabetic-adult-patients-with-chronic-kidney-disease
#14
Satyendra Kumar Sonkar, Mohit Bhutani, Gyanendra Kumar Sonkar, Sant Kumar Pandey, Sharad Chandra, Vivek Bhosale
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in patients with end-stage renal disease. Chronic kidney disease (CKD)-associated cardiovascular mortality is more prevalent in those with diastolic heart failure and is an early predictor, while increased left ventricular mass (LVM) is a strong independent risk factor. Hypovitaminosis D is extensively being studied as a nontraditional risk factor for CVD. The aim of the present study is to look at the association of Vitamin D and other parameters of mineral bone disorder (MBD) with diastolic dysfunction and LVM in nondiabetic young adult patients with CKD...
July 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28714993/a-two-helix-motif-positions-the-lysophosphatidic-acid-acyltransferase-active-site-for-catalysis-within-the-membrane-bilayer
#15
Rosanna M Robertson, Jiangwei Yao, Stefan Gajewski, Gyanendra Kumar, Erik W Martin, Charles O Rock, Stephen W White
Phosphatidic acid (PA), the central intermediate in membrane phospholipid synthesis, is generated by two acyltransferases in a pathway conserved in all life forms. The second step in this pathway is catalyzed by 1-acyl-sn-glycerol-3-phosphate acyltransferase, called PlsC in bacteria. Here we present the crystal structure of PlsC from Thermotoga maritima, revealing an unusual hydrophobic/aromatic N-terminal two-helix motif linked to an acyltransferase αβ-domain that contains the catalytic HX4D motif. PlsC dictates the acyl chain composition of the 2-position of phospholipids, and the acyl chain selectivity 'ruler' is an appropriately placed and closed hydrophobic tunnel...
August 2017: Nature Structural & Molecular Biology
https://www.readbyqxmd.com/read/28708503/effect-of-dietary-supplementation-of-omega-3-polyunsaturated-fatty-acid-pufa-rich-fish-oil-on-reproductive-performance-of-the-goat-capra-hircus
#16
Ajit Singh Mahla, Ravjibhai K Chaudhari, Atul Kumar Verma, Amit Kumar Singh, Sanjay Kumar Singh, Gyanendra Singh, Mihir Sarkar, Narayan Dutta, Harendra Kumar, Narayanan Krishnaswamy
Dietary supplementation of n-3 PUFA decreases the luteolytic PGF2α and improves the pregnancy rate in the dairy cow. However, its effect in the goat is not known. Accordingly, we studied the effect of supplementation of n-3 PUFA rich Fish oil (FO) on different reproductive events in the goat. Cycling goats (n = 30) were divided into two equal groups and fed an isocaloric and isonitrogenous diet supplemented with either FO (TRT; n = 15) or palm oil (PO) (CON; n = 15) @ 0.6 mL/kg body weight for 72 days during the breeding season...
May 26, 2017: Theriogenology
https://www.readbyqxmd.com/read/28663521/intra-arterial-vasodilators-for-vasospasm-following-aneurysmal-subarachnoid-hemorrhage-a-meta-analysis
#17
Anand Venkatraman, Ayaz M Khawaja, Sahil Gupta, Shalaka Hardas, John P Deveikis, Mark R Harrigan, Gyanendra Kumar
OBJECTIVE: The efficacy of intra-arterial vasodilators (IADs) for the treatment of vasospasm following aneurysmal subarachnoid hemorrhage (aSAH) remains debatable. The objective of this meta-analysis was to pool estimates of angiographic and neurological response, clinical outcome, and mortality following treatment of vasospasm with IADs. METHODS: We searched PubMed, Embase, Scopus, Clinicaltrials.gov, Cochrane database, and CINAHL in December 2015 and August 2016...
June 29, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/28644260/intravenous-alteplase-for-acute-stroke-and-pulmonary-embolism-in-a-patient-with-recent-abdominoplasty
#18
Michael E Christiansen, Gyanendra Kumar, Raman C Mahabir, Richard A Helmers, Bernard R Bendok, Cumara B O'Carroll
INTRODUCTION: Major surgery in the past 14 days is a relative contraindication to treatment of acute stroke with intravenous (IV) alteplase. The 2016 American Heart Association/American Stroke Association scientific statement discussing inclusion and exclusion criteria for alteplase in acute stroke allows for provider judgment citing a lack of evidence to support surgery as an absolute contraindication. CASE REPORT: A 59-year-old woman presented with acute left hemiparesis, dysarthria, and acute respiratory failure...
July 2017: Neurologist
https://www.readbyqxmd.com/read/28573536/exploring-the-heat-responsive-chaperones-and-microsatellite-markers-associated-with-terminal-heat-stress-tolerance-in-developing-wheat
#19
Ranjeet R Kumar, Suneha Goswami, Mohammad Shamim, Kavita Dubey, Khushboo Singh, Shweta Singh, Yugal K Kala, Ravi R K Niraj, Akshay Sakhrey, Gyanendra P Singh, Monendra Grover, Bhupinder Singh, Gyanendra K Rai, Anil K Rai, Viswanathan Chinnusamy, Shelly Praveen
Global warming is a major threat for agriculture and food security, and in many cases the negative impacts are already apparent. Wheat is one of the most important staple food crops and is highly sensitive to the heat stress (HS) during reproductive and grain-filling stages. Here, whole transcriptome analysis of thermotolerant wheat cv. HD2985 was carried out at the post-anthesis stage under control (22 ± 3 °C) and HS-treated (42 °C, 2 h) conditions using Illumina Hiseq and Roche GS-FLX 454 platforms...
June 1, 2017: Functional & Integrative Genomics
https://www.readbyqxmd.com/read/28573410/depressed-polymorphonuclear-cell-functions-in-periparturient-cows-that-develop-postpartum-reproductive-diseases
#20
Rafiqul Islam, Harendra Kumar, Gyanendra Singh, Binsila B Krishnan, Sahadeb Dey
The study was planned to see if there is any important and significant changes in the PMN function in cows suffering from postpartum reproductive diseases (PRD). Blood sampling was done from 41 pregnant cows on 15 days prepartum (-15d), calving day (0d), 15 days (15d) and 30 days (30d) postpartum and thorough gynaecological examination was performed on 0d, 15d, 30d and 45d for diagnosis of PRD like retained placenta (RP), clinical metritis (CM), clinical endometritis (CE) and delayed involution of uterus (DIU)...
September 2017: Veterinary Research Communications
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