keyword
MENU ▼
Read by QxMD icon Read
search

Gyanendra Kumar

keyword
https://www.readbyqxmd.com/read/29746879/characterization-of-novel-heat-responsive-transcription-factor-tahsfa6e-gene-involved-in-regulation-of-heat-shock-proteins-hsps-a-key-member-of-heat-stress-tolerance-network-of-wheat
#1
Ranjeet R Kumar, Suneha Goswami, Khushboo Singh, Kavita Dubey, Gyanendra K Rai, Bhupinder Singh, Shivdhar Singh, Monendra Grover, Dwijesh Mishra, Sanjeev Kumar, Suman Bakshi, Anil Rai, Himanshu Pathak, Viswanathan Chinnusamy, Shelly Praveen
Heat stress has an adverse effect on the quality and quantity of agriculturally important crops, especially wheat. The tolerance mechanism has not been explored much in wheat and very few genes/ TFs responsive to heat stress is available on public domain. Here, we identified, cloned and characterized a putative TaHSFA6e TF gene of 1.3 kb from wheat cv. HD2985. We observed an ORF of 368 aa with Hsf DNA binding signature domain in the amino acid sequence. Single copy number of TaHSFA6e was observed integrated in the genome of wheat...
May 7, 2018: Journal of Biotechnology
https://www.readbyqxmd.com/read/29691337/identification-of-the-i38t-pa-substitution-as-a-resistance-marker-for-next-generation-influenza-virus-endonuclease-inhibitors
#2
Jeremy C Jones, Gyanendra Kumar, Subrata Barman, Isabel Najera, Stephen W White, Richard J Webby, Elena A Govorkova
The clinical severity and annual occurrence of influenza virus epidemics, combined with the availability of just a single class of antivirals to treat infections, underscores the urgent need to develop new anti-influenza drugs. The endonuclease activity within the viral acidic polymerase (PA) protein is an attractive target for drug discovery due to the critical role it plays in viral gene transcription. RO-7 is a next-generation PA endonuclease inhibitor of influenza A and B viruses, but its drug resistance potential is unknown...
April 24, 2018: MBio
https://www.readbyqxmd.com/read/29571764/retinal-microvascular-abnormalities-as-surrogate-markers-of-cerebrovascular-ischemic-disease-a-meta-analysis
#3
Oana M Dumitrascu, Bart M Demaerschalk, Cristina Valencia Sanchez, Diana Almader-Douglas, Cumara B O'Carroll, Maria I Aguilar, Patrick D Lyden, Gyanendra Kumar
BACKGROUND: To determine the predictive value of retinal microvascular abnormalities for cerebrovascular ischemic diseases (CVDs), we aimed to investigate the quantitative association between retinal microvascular changes and CVD subcategories: white matter hyperintensities (WMHIs), lacunar infarcts (LIs), and cerebral infarctions (CIs). METHODS: Using Meta-analyses Of Observational Studies in Epidemiology guidelines, we searched 6 databases through September 2016 for studies evaluating the linkage between retinal microvascular abnormalities and WMHI, and LI and CI...
March 20, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29494438/admission-systolic-blood-pressure-predicts-the-number-of-blood-pressure-medications-at-discharge-in-patients-with-primary-intracerebral-hemorrhage
#4
Ayaz M Khawaja, Harn Shiue, Amelia K Boehme, Karen C Albright, Anand Venkatraman, Gyanendra Kumar, Michael J Lyerly, Angela Hays-Shapshak, Maira Mirza, Toby I Gropen, Mark R Harrigan
BACKGROUND: Control of systolic blood pressure (SBP) after primary intracerebral hemorrhage improves outcomes. Factors determining the number of blood pressure medications (BPM) required for goal SBP<160 mm Hg at discharge are unknown. We hypothesized that higher admission-SBPs require a greater number of BPM for goal discharge-SBP<160 mm Hg, and investigated factors influencing this goal. MATERIALS AND METHODS: We conducted a retrospective review of 288 patients who presented with primary intracerebral hemorrhage...
March 2018: Neurologist
https://www.readbyqxmd.com/read/29466880/telmisartan-reverses-antiretroviral-induced-adipocyte-toxicity-and-insulin-resistance-in-vitro
#5
Sudeep P Pushpakom, Antonysunil Adaikalakoteswari, Andrew Owen, David J Back, Gyanendra Tripathi, Sudhesh Kumar, Philip McTernan, Munir Pirmohamed
BACKGROUND: Antiretroviral therapy in HIV-positive patients leads to insulin resistance which is central to the pathogenesis of various metabolic abnormalities and cardiovascular disease seen in this patient group. We have investigated the dose-response relationship of telmisartan, an antihypertensive, on adipocytes in vitro in order to determine whether it may have metabolic beneficial effects. METHODS: Using in vitro chronic toxicity models (3T3-F442A murine and primary human adipocytes), we evaluated the effects of different concentrations of telmisartan on adipocyte differentiation and adipogenic gene expression using lipid accumulation assays and real-time polymerase chain reaction, respectively...
May 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29448951/t-arms-pcr-genotyping-of-snp-rs445709131-using-thermostable-strand-displacement-polymerase
#6
Rafeeque R Alyethodi, Umesh Singh, Sushil Kumar, Rani Alex, Rajib Deb, Gyanendra S Sengar, T V Raja, B Prakash
OBJECTIVES: In a recent publication, we reported the successful use of tetra primer-amplification refractory mutation system based polymerase chain reaction (T-ARMS-PCR) for genotyping of rs445709131-SNP responsible for the bovine leukocyte adhesion deficiency (BLAD) in cattle. The SNP is characterized by higher GC content of the surrounding region, hence, the previous protocol utilized dimethyl sulfoxide as PCR enhancer. Here, the reaction cocktail was modified with the use of thermostable strand displacement polymerase (SD polymerase) instead of commonly used Taq DNA Polymerase...
February 15, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29430420/drug-safety-alerts-of-pharmacovigilance-programme-of-india-a-scope-for-targeted-spontaneous-reporting-in-india
#7
Prasad Thota, Anusha Thota, Bikash Medhi, Shabir Sidhu, Pramod Kumar, V Kalai Selvan, Gyanendra Nath Singh
Background: The National Coordination Centre-Pharmacovigilance Programme of India (NCC-PvPI), Indian Pharmacopoeia Commission works under the aegis of Ministry of Health and Family Welfare, Government of India. It promotes patient safety in India and also supports postmarketing surveillance programs. Currently, almost hundred thousand case reports are submitted to NCC-PvPI each year through its 250 ADR Monitoring Centers (AMCs) located across India, and India is the one of the top ten contributor countries under WHO-Uppsala Monitoring Centre since 2012 and start issuing drug safety alerts from March 2016...
January 2018: Perspectives in Clinical Research
https://www.readbyqxmd.com/read/29427237/differential-expression-of-lp-pla2-in-obesity-and-type-2-diabetes-and-the-influence-of-lipids
#8
Laura Jackisch, Warunee Kumsaiyai, Jonathan D Moore, Nasser Al-Daghri, Ioannis Kyrou, Thomas M Barber, Harpal Randeva, Sudhesh Kumar, Gyanendra Tripathi, Philip G McTernan
AIMS/HYPOTHESIS: Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a circulatory macrophage-derived factor that increases with obesity and leads to a higher risk of cardiovascular disease (CVD). Despite this, its role in adipose tissue and the adipocyte is unknown. Therefore, the aims of this study were to clarify the expression of Lp-PLA2 in relation to different adipose tissue depots and type 2 diabetes, and ascertain whether markers of obesity and type 2 diabetes correlate with circulating Lp-PLA2...
May 2018: Diabetologia
https://www.readbyqxmd.com/read/29406710/heterocyclic-fused-pyrimidines-as-novel-tubulin-polymerization-inhibitors-targeting-the-colchicine-binding-site-structural-basis-and-antitumor-efficacy
#9
Souvik Banerjee, Kinsie E Arnst, Yuxi Wang, Gyanendra Kumar, Shanshan Deng, Lei Yang, Guo-Bo Li, Jinliang Yang, Stephen W White, Wei Li, Duane D Miller
We report the design, synthesis, and biological evaluation of heterocyclic-fused pyrimidines as tubulin polymerization inhibitors targeting the colchicine binding site with significantly improved therapeutic index. Additionally, for the first time, we report high-resolution X-ray crystal structures for the best compounds in this scaffold, 4a, 4b, 6a, and 8b. These structures not only confirm their direct binding to the colchicine site in tubulin and reveal their detailed molecular interactions but also contrast the previously published proposed binding mode...
February 22, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29302549/validity-of-indian-diabetes-risk-score-and-its-association-with-body-mass-index-and-glycosylated-hemoglobin-for-screening-of-diabetes-in-and-around-areas-of-lucknow
#10
Mohammad Mustufa Khan, Gyanendra Kumar Sonkar, Roshan Alam, Sudhir Mehrotra, M Salman Khan, Ajay Kumar, Satyendra Kumar Sonkar
Objectives: The present study aimed to assess the validity of Indian Diabetes Risk Score (IDRS) and its association with body mass index (BMI) and glycosylated hemoglobin (HbA1c) for screening of diabetes and obesity. Methodology: A cross-sectional study was designed, and samples were randomly enrolled from Lucknow and its adjoining areas. Totally, 405 subjects were included in the study. We used diabetes risk factors (age, waist circumference, physical activity, and family history of diabetes) for screening of diabetes and abdominal obesity (AO) and BMI for screening of general obesity...
April 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29231735/novel-folate-binding-protein-in-arabidopsis-expressed-during-salicylic-acid-induced-folate-accumulation
#11
Bijesh Puthusseri, Peethambaran Divya, Veeresh Lokesh, Gyanendra Kumar, Mohammed Azharuddin Savanur, Bhagyalakshmi Neelwarne
Increasing the quantity of natural folates in plant foods is recently gaining significant interest, owing to their acute deficiencies in various populations. This study observed that foliar salicylic acid treatment enhanced the accumulation of folates in Arabidopsis, which correlated with the increase in a folate binding protein (FBP) and the expression of mRNA of a putative folate binding protein At5G27830. A protein band corresponding to ∼43 kDa was observed after resolving the affinity-purified protein on SDS-PAGE, and the partial amino acid sequence indicated that the protein is indeed At5G27830...
January 17, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29215062/protein-structure-assisted-optimization-of-4-5-dihydroxypyrimidine-6-carboxamide-inhibitors-of-influenza-virus-endonuclease
#12
Diane Beylkin, Gyanendra Kumar, Wei Zhou, Jaehyeon Park, Trushar Jeevan, Chandraiah Lagisetti, Rhodri Harfoot, Richard J Webby, Stephen W White, Thomas R Webb
Influenza is a serious hazard to human health that causes hundreds of thousands of deaths annually. Though vaccines and current therapeutics can blunt some of the perilous impact of this viral infection, new treatments are needed due to the constantly evolving nature of this virus. Recently, our growing understanding of an essential influenza viral protein, PA, has led to the development of focused libraries of new small molecules that specifically target the active site of the PA influenza endonuclease, which we report here...
December 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29118496/visual-outcome-and-complications-of-various-techniques-of-secondary-intraocular-lens
#13
Santosh Kumar, Satyaprakash Singh, Gyanendra Singh, Nilesh S Rajwade, Sushank A Bhalerao, Vinod Singh
BACKGROUND/AIMS: The purpose of this study was to compare and evaluate the visual outcome and complications of various techniques of secondary intraocular lens (IOL) (i.e., anterior chamber IOL [ACIOL], suture-fixated posterior chamber IOL [PCIOL], and glue-fixated PCIOL). STUDY DESIGN AND SETTING: This was a randomized, prospective, interventional, comparative, clinical trial study. SUBJECTS AND METHODS: Patients of either sex having aphakia and lacking posterior capsular support were included in the study, and patients having corneal or scleral pathology, optic atrophy, uncontrolled glaucoma, retinal detachment, and other retinal pathology were excluded from the study...
September 2017: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/29037729/evaluation-of-folate-binding-proteins-and-stability-of-folates-in-plant-foliages
#14
Bijesh Puthusseri, Peethambaran Divya, Lokesh Veeresh, Gyanendra Kumar, Bhagyalakshmi Neelwarne
The present study reports the presence of folate binding proteins (FBPs) in the plants, coriander and Arabidopsis, and their contributions toward folate enhancement. After observing that salicylic acid (SA) enhanced the accumulation of folates in coriander, a study was conducted in Arabidopsis, where twofold increase in folates occurred in foliage upon SA treatment. For obtaining insights into genes involved in SA-induced folate accumulation, microarray data of responsive genes in Arabidopsis were screened...
March 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28979274/biochemical-defense-response-characterizing-the-plasticity-of-source-and-sink-in-spring-wheat-under-terminal-heat-stress
#15
Ranjeet R Kumar, Suneha Goswami, Mohammed Shamim, Upama Mishra, Monika Jain, Khushboo Singh, Jyoti P Singh, Kavita Dubey, Shweta Singh, Gyanendra K Rai, Gyanendra P Singh, Himanshu Pathak, Viswanathan Chinnusamy, Shelly Praveen
Wheat is highly prone to terminal heat stress (HS) under late-sown conditions. Delayed- sowing is one of the preferred methods to screen the genotypes for thermotolerance under open field conditions. We investigated the effect of terminal HS on the thermotolerance of four popular genotypes of wheat i.e. WR544, HD2967, HD2932, and HD2285 under field condition. We observed significant variations in the biochemical parameters like protein content, antioxidant activity, proline and total reducing sugar content in leaf, stem, and spike under normal (26 ± 2°C) and terminal HS (36 ± 2°C) conditions...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28942841/exploitation-of-agro-climatic-environment-for-selection-of-1-aminocyclopropane-1-carboxylic-acid-acc-deaminase-producing-salt-tolerant-indigenous-plant-growth-promoting-rhizobacteria
#16
Sankalp Misra, Vijay Kant Dixit, Mohammad Haneef Khan, Shashank Kumar Mishra, Gyanendra Dviwedi, Sumit Yadav, Alok Lehri, Puneet Singh Chauhan
A comprehensive survey for 09 agro-climatic zones of Uttar Pradesh, India was conducted to isolate and characterize salt tolerant 1-aminocyclopropane-1-carboxylic acid (ACC) deaminase possessing plant growth promoting (PGP) rhizobacteria for salt stress amelioration in rice. Here, we have isolated 1125 bacteria having the ability to tolerate 1M NaCl and out of those, 560 were screened for utilizing ACC as sole nitrogen source. 560 isolates were subjected for bacteria coated seed germination assay under 100mM salt (NaCl) stress resulting to 77 isolates which were further evaluated for seed germination assay, PGP and abiotic stress tolerance ability in vitro...
December 2017: Microbiological Research
https://www.readbyqxmd.com/read/28890621/soft-tissue-applications-of-er-cr-ysgg-laser-in-pediatric-dentistry
#17
Gyanendra Kumar, Ferah Rehman, Vivek Chaturvedy
Soft tissue laser, such as diode and Nd:YAG lasers were initially used in soft tissue lesions because of its increased success rate. It was because of the fact that these lasers were well-absorbed by chromophores, such as hemoglobin and melanin which are found abundant in the oral mucosa. The introduction of erbium family in 1990 comprising the Er:YAG and Er,Cr:YSGG lasers made the hard tissue laser a boon for dentistry. Erbium, chromium-doped yttrium, scandium, gallium and garnet (Er,Cr:YSGG) was introduced in 1997 for the surgical needs of clinical dentistry in general practice...
April 2017: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28843678/supplementation-of-vitamin-e-selenium-and-increased-energy-allowance-mitigates-the-transition-stress-and-improves-postpartum-reproductive-performance-in-the-crossbred-cow
#18
Amit Khatti, Sanjeev Mehrotra, Pankaj Kumar Patel, Gyanendra Singh, Vijai Prakash Maurya, Ajit Singh Mahla, Ravjibhai Karshanbhai Chaudhari, Gautam Kumar Das, Mithilesh Singh, Mihir Sarkar, Harendra Kumar, Narayanan Krishnaswamy
Dairy cow undergoes tremendous physiological challenges during the transition period leading to negative energy balance (NEBAL), impaired immunity and oxidative stress that ultimately compromises the postpartum fertility. Accordingly, we investigated the effects of antioxidant supplementation and increased energy allowance on transition stress and fertility of crossbred cow. Advanced pregnant crossbred cows (n = 26) of 2-4 parity and lactation potential of >10 L/day were divided into two equal groups (n = 13 cows/group)...
August 16, 2017: Theriogenology
https://www.readbyqxmd.com/read/28793327/qtl-mapping-for-nine-drought-responsive-agronomic-traits-in-bread-wheat-under-irrigated-and-rain-fed-environments
#19
Vijay Gahlaut, Vandana Jaiswal, Bhudeva S Tyagi, Gyanendra Singh, Sindhu Sareen, Harindra S Balyan, Pushpendra Kumar Gupta
In bread wheat, QTL interval mapping was conducted for nine important drought responsive agronomic traits. For this purpose, a doubled haploid (DH) mapping population derived from Kukri/Excalibur was grown over three years at four separate locations in India, both under irrigated and rain-fed environments. Single locus analysis using composite interval mapping (CIM) allowed detection of 98 QTL, which included 66 QTL for nine individual agronomic traits and 32 QTL, which affected drought sensitivity index (DSI) for the same nine traits...
2017: PloS One
https://www.readbyqxmd.com/read/28789682/additional-burden-of-asymptomatic-and-sub-patent-malaria-infections-during-low-transmission-season-in-forested-tribal-villages-in-chhattisgarh-india
#20
Mehul Kumar Chourasia, Kamaraju Raghavendra, Rajendra M Bhatt, Dipak Kumar Swain, Hemraj M Meshram, Jayant K Meshram, Shrity Suman, Vinita Dubey, Gyanendra Singh, Kona Madhavinadha Prasad, Immo Kleinschmidt
BACKGROUND: The burden of sub-patent malaria is difficult to recognize in low endemic areas due to limitation of diagnostic tools, and techniques. Polymerase chain reaction (PCR), a molecular based technique, is one of the key methods for detection of low parasite density infections. The study objective was to assess the additional burden of asymptomatic and sub-patent malaria infection among tribal populations inhabiting three endemic villages in Keshkal sub-district, Chhattisgarh, India...
August 8, 2017: Malaria Journal
keyword
keyword
116049
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"