keyword
https://read.qxmd.com/read/38479212/report-of-a-collaborative-study-to-establish-the-first-indian-pharmacopoeia-reference-standard-for-teriparatide
#1
JOURNAL ARTICLE
Gaurav Pratap Singh Jadaun, M Kalaivani, Mukesh Kumar, Gyanendra Nath Singh, Rajeev Singh Raghuvanshi, Parveen Jain
A collaborative study was conducted to establish the first Indian Pharmacopoeia Reference Standard (IPRS) for teriparatide to be used in quality control testing of marketed products in compliance with the Indian Pharmacopoeia (IP) monograph. The study objective was to evaluate the candidate standard in terms of the WHO International Standard (IS) to assign its content in mg per vial terms. This study involved four laboratories from India and the candidate standard was calibrated against the WHO IS by each participant laboratory using high-performance liquid chromatography (HPLC) assay method per IP monograph...
March 12, 2024: Biologicals: Journal of the International Association of Biological Standardization
https://read.qxmd.com/read/38386640/unravelling-the-novel-genetic-diversity-and-marker-trait-associations-of-corn-leaf-aphid-resistance-in-wheat-using-microsatellite-markers
#2
JOURNAL ARTICLE
Jayant Yadav, Poonam Jasrotia, Maha Singh Jaglan, Sindhu Sareen, Prem Lal Kashyap, Sudheer Kumar, Surender Singh Yadav, Gyanendra Singh, Gyanendra Pratap Singh
The study was conducted to identify novel simple sequence repeat (SSR) markers associated with resistance to corn aphid (CLA), Rhopalosiphum maidis L. in 48 selected bread wheat (Triticum aestivum L.) and wild wheat (Aegilops spp. & T. dicoccoides) genotypes during two consecutive cropping seasons (2018-19 and 2019-20). A total of 51 polymorphic markers containing 143 alleles were used for the analysis. The frequency of the major allele ranged from 0.552 (Xgwm113) to 0.938 (Xcfd45, Xgwm194 and Xgwm526), with a mean of 0...
2024: PloS One
https://read.qxmd.com/read/38381218/transcriptome-signatures-of-host-tissue-infected-with-african-swine-fever-virus-reveal-differential-expression-of-associated-oncogenes
#3
JOURNAL ARTICLE
Rajib Deb, Gyanendra Singh Sengar, Joyshikh Sonowal, Seema Rani Pegu, Pranab Jyoti Das, Indra Singh, Soumendu Chakravarti, Arutkumaran Selvaradjou, Nitin Attupurum, Swaraj Rajkhowa, Vivek Kumar Gupta
African swine fever (ASF) has emerged as a threat to swine production worldwide. Evasion of host immunity by ASF virus (ASFV) is well understood. However, the role of ASFV in triggering oncogenesis is still unclear. In the present study, ASFV-infected kidney tissue samples were subjected to Illumina-based transcriptome analysis. A total of 2463 upregulated and 825 downregulated genes were differentially expressed (p < 0.05). A literature review revealed that the majority of the differentially expressed host genes were key molecules in signaling pathways involved in oncogenesis...
February 21, 2024: Archives of Virology
https://read.qxmd.com/read/38376271/effective-proliferation-control-of-mcf7-breast-cancer-using-microsecond-duration-electrical-pulse
#4
JOURNAL ARTICLE
Gyanendra Kumar, R Sarathi, Archana Sharma
BACKGROUND: Electro-permeablization using a pulse generator is a novel non-invasive approach for cancer therapy. It serves as a cell permeability enhancing agent for cancer treatment. OBJECTIVE: In this article in vitro investigation of the effect of 1.0 kV/cm, 1.5 kV/cm and 2.0 kV/cm, 50 µs duration pulsed electric field on MCF-7 cell line has been done. Furthermore, combinational therapy of curcumin and electrical pulses has been also investigated. MATERIAL AND METHOD: A variable voltage (100 V-1200 V, 100 V step) and 50 µs duration pulse generator has been designed, which is further used for the investigation of electroporation and destructive electrical field intensity...
October 1, 2023: Journal of Cancer Research and Therapeutics
https://read.qxmd.com/read/38373874/new-insights-into-qtns-and-potential-candidate-genes-governing-rice-yield-via-a-multi-model-genome-wide-association-study
#5
JOURNAL ARTICLE
Supriya Sachdeva, Rakesh Singh, Avantika Maurya, Vikas K Singh, Uma Maheshwar Singh, Arvind Kumar, Gyanendra Pratap Singh
BACKGROUND: Rice (Oryza sativa L.) is one of the globally important staple food crops, and yield-related traits are prerequisites for improved breeding efficiency in rice. Here, we used six different genome-wide association study (GWAS) models for 198 accessions, with 553,229 single nucleotide markers (SNPs) to identify the quantitative trait nucleotides (QTNs) and candidate genes (CGs) governing rice yield. RESULTS: Amongst the 73 different QTNs in total, 24 were co-localized with already reported QTLs or loci in previous mapping studies...
February 20, 2024: BMC Plant Biology
https://read.qxmd.com/read/38309206/incidences-of-helicobacter-infection-in-pigs-and-tracing-occupational-hazard-in-pig-farmers
#6
JOURNAL ARTICLE
Seema Rani Pegu, Joyshikh Sonowal, Swaraj Rajkhowa, Pranab Jyoti Das, Gyanendra Singh Sengar, Rajib Deb, Manjisa Choudhury, Naba Jyoti Deka, Souvik Paul, Juwar Doley, Dilip Kumar Sarma, Samir Das, N H Mohan, Rajendran Thomas, Vivek Kumar Gupta
Helicobacter species (spp.) is a gram-negative spiral-shaped motile bacterium that causes gastritis in pigs and also colonizes in the human stomach. The present study assessed the prevalence of Helicobacter spp. in pig gastric mucosa and the stool of pig farmers in Assam, India. A total of 403 stomach samples from pig slaughter points, 74 necropsy samples of pigs from pig farms, and 97 stool samples from pig farmers were collected. Among the pig stomach samples, 43 (20.09%) of those with gastritis showed the presence of Gram-negative, spiral-shaped organisms, while only 3...
January 15, 2024: Comparative Immunology, Microbiology and Infectious Diseases
https://read.qxmd.com/read/38302883/a-methodical-exploration-of-imaging-modalities-from-dataset-to-detection-through-machine-learning-paradigms-in-prominent-lung-disease-diagnosis-a-review
#7
REVIEW
Sunil Kumar, Harish Kumar, Gyanendra Kumar, Shailendra Pratap Singh, Anchit Bijalwan, Manoj Diwakar
BACKGROUND: Lung diseases, both infectious and non-infectious, are the most prevalent cause of mortality overall in the world. Medical research has identified pneumonia, lung cancer, and Corona Virus Disease 2019 (COVID-19) as prominent lung diseases prioritized over others. Imaging modalities, including X-rays, computer tomography (CT) scans, magnetic resonance imaging (MRIs), positron emission tomography (PET) scans, and others, are primarily employed in medical assessments because they provide computed data that can be utilized as input datasets for computer-assisted diagnostic systems...
February 1, 2024: BMC Medical Imaging
https://read.qxmd.com/read/38268209/kisspeptin-stimulates-oestradiol-biosynthesis-by-upregulating-steroidogenic-transcripts-and-proliferation-markers-in-the-bubaline-granulosa-cells-in%C3%A2-vitro
#8
JOURNAL ARTICLE
Renu Sharma, Manas Kumar Patra, Thejaswini Meda Puttanarsappa, Hitesh, Mohammad Rehan Ahmad Raza, Tarun Kumar Sahu, Karikalan Mathesh, Zunjar Baburao Dubal, Subrata Kumar Ghosh, Gyanendra Kumar Gaur, Goutam Kumar Das, Sanjay Kumar Singh, Narayanan Krishnaswamy
Kisspeptin (Kp), an upstream regulator of GnRH release, is essential for the development and function of reproductive axis. Previously, we demonstrated the localization of Kp and its receptor (Kiss1r) in the active follicle in the bubaline ovary. Present study aimed to determine the effect of Kp on granulosa cell (GCs) functions, especially oestradiol (E2 ) and progesterone (P4 ) production, and differential expression of genes regulating the proliferation, apoptosis and steroidogenesis in the buffalo. The ovaries with 6-10 mm size follicles obtained from the cyclic buffaloes after slaughtering were used for isolation of GCs for in vitro study...
January 2024: Reproduction in Domestic Animals
https://read.qxmd.com/read/38221748/genome-wide-association-mapping-for-field-spot-blotch-resistance-in-south-asian-spring-wheat-genotypes
#9
JOURNAL ARTICLE
Umesh Kamble, Xinyao He, Sudhir Navathe, Manjeet Kumar, Madhu Patial, Muhammad Rezaul Kabir, Gyanendra Singh, Gyanendra Pratap Singh, Arun Kumar Joshi, Pawan Kumar Singh
Spot blotch caused by Bipolaris sorokiniana ((Sacc.) Shoemaker) (teleomorph: Cochliobolus sativus [Ito and Kuribayashi] Drechsler ex Dastur) is an economically important disease of warm and humid regions. The present study focused on identifying resistant genotypes and single-nucleotide polymorphism (SNP) markers associated with spot blotch resistance in a panel of 174 bread spring wheat lines using field screening and genome-wide association mapping strategies. Field experiments were conducted in Agua Fria, Mexico, during the 2019-2020 and 2020-2021 cropping seasons...
January 14, 2024: Plant Genome
https://read.qxmd.com/read/38172456/genetic-analysis-of-first-lactation-and-lifetime-performance%C3%A2-traits-in-composite-vrindavani-cattle-important-considerations-for-higher-milk-production
#10
JOURNAL ARTICLE
K Tamilarasan, Sheikh Firdous Ahmad, Snehasmita Panda, A Latha Preethi, Ayon Tarafdar, Hari Om Pandey, Gyanendra Kumar Gaur
The present study was aimed to evaluate the influence of non-genetic factors on several first lactation and lifetime performance traits and elucidate their genetic parameters in an organized Vrindavani cattle population. Data on eight first-lactation and thirteen lifetime traits were collected on 2400 cows with pedigree records that were reared during 33-year period (1989-2021). The first-lactation traits included age at first calving (AFC), total milk yield (FTMY), standard milk yield (FSMY305), peak yield (FPY), lactation length (FLL), dry period (FDP), service period (FSP) and calving interval (FCI)...
January 4, 2024: Tropical Animal Health and Production
https://read.qxmd.com/read/38165873/impact-of-sn-doping-on-the-optoelectronic-properties-of-zinc-oxide-crystal-dft-approach
#11
JOURNAL ARTICLE
Manoj Kumar, Purnendu Shekhar Pandey, Banoth Ravi, Bittu Kumar, S V S Prasad, Rajesh Singh, Santosh Kumar Choudhary, Gyanendra Kumar Singh
This study aims to provide a concise overview of the behavior exhibited by Sn-doped ZnO crystals using a computational technique known as density functional theory (DFT). The influence of Sn doping on the electronic, structural, and optical properties of ZnO have been explored. Specifically, the wavelength dependent refractive index, extinction coefficient, reflectance, and absorption coefficient, along with electronic band gap structure of the Sn doped ZnO has been examined and analyzed. In addition, X-ray diffraction (XRD) patterns have been obtained to investigate the structural characteristics of Sn-doped ZnO crystals with varying concentrations of Sn dopant atoms...
2024: PloS One
https://read.qxmd.com/read/38144240/a-systematic-review-of-techniques-for-step-cut-osteotomy-in-cubitus-varus-a-comprehensive-analysis
#12
REVIEW
Ankit Khurana, Nitin Kumar, Vandana Chugh, Kirubakaran Pattabiraman, Jujhar Singh, Gyanendra Verma
BACKGROUND: Cubitus varus, a common post-traumatic deformity of the elbow in children, poses challenges for both patients and surgeons. Step cut osteotomy has emerged as a reasonable surgical technique to address this condition, offering multiple approaches and modifications. METHODS: We present a comprehensive systematic review of techniques for step cut osteotomy in cubitus varus, analyzing 13 studies that meet our inclusion criteria. These studies encompass diverse patient populations, including pediatric and adult cases, and span different geographical regions...
March 2024: Journal of Orthopaedics
https://read.qxmd.com/read/38108059/psychiatric-manifestations-of-myhre-syndrome-a-case-report
#13
JOURNAL ARTICLE
Vasundhara Bhushan, Gyanendra Kumar, Arti Yadav, Sheetal Tripathi
No abstract text is available yet for this article.
October 2023: Indian Journal of Psychiatry
https://read.qxmd.com/read/38097647/proximity-induced-band-gap-opening-in-topological-magnetic-heterostructure-ni-80-fe-20-p-tlbise-2-p-si-under-ambient-condition
#14
JOURNAL ARTICLE
Roshani Singh, Gyanendra Kumar Maurya, Vidushi Gautam, Rachana Kumar, Mahesh Kumar, K G Suresh, Brahmaranjan Panigrahi, Chandrasekhar Murapaka, Arbinda Haldar, Pramod Kumar
The broken time reversal symmetry states may result in the opening of a band gap in TlBiSe2 leading to several interesting phenomena which are potentially relevant for spintronic applications. In this work, the quantum interference and magnetic proximity effects have been studied in Ni80 Fe20 /p-TlBiSe2 /p-Si (Magnetic/TI) heterostructure using physical vapor deposition technique. Raman analysis shows the symmetry breaking with the appearance of A2 1u mode. The electrical characteristics are investigated under dark and illumination conditions in the absence as well as in the presence of a magnetic field...
December 15, 2023: Scientific Reports
https://read.qxmd.com/read/38078029/comparative-evaluation-of-clinical-and-radiographic-success-of-pulpectomy-done-with-and-without-dental-operating-microscope-in-pediatric-patients-an-in-vivo-study
#15
JOURNAL ARTICLE
Gyanendra Kumar, Ferah Rehman
AIM: To assess the clinical and radiographic success of conventional pulpectomy and pulpectomy done under an endodontic microscope over a period of 12 months. MATERIALS AND METHODS: The study was conducted as a single-blinded, parallel-group prospective, randomized, and controlled clinical trial. The enrollment of the study involved the assessment of 258 deciduous molars for eligibility as per the inclusion criteria. A total of 104 teeth were allocated to each group, that is, group I (conventional pulpectomy) and group II (pulpectomy under microscope)...
September 2023: International Journal of Clinical Pediatric Dentistry
https://read.qxmd.com/read/38051406/in-vitro-screening-of-molecular-diversity-among-sorghums-sorghum-bicolor-l-landraces-in-marathwada-region-by-molecular-markers
#16
JOURNAL ARTICLE
Vikas Manikrao Shukre, Rushikesh Tahakik, Kunvar Gyanendra Kumar, Shilpa Hanmatrao Tarte, Ganesh Kore
Allelic variation is a valuable tool for displaying high levels of polymorphism within species and is closely correlated with crop productivity. In Marathawada, there is a significant amount of phenotypic heterogeneity among sorghum landraces. However, molecular variability needs to be reevaluated in order to identify any potential barriers that can interfere with current improvement initiatives. In the current work, we used 5 SSR markers to categorize 20 genotypes of elite (Sorghum bicolor L. Moench) accession from the Marathwada region, including one standard cultivar from various agro-economic zones...
December 5, 2023: Applied Biochemistry and Biotechnology
https://read.qxmd.com/read/38041718/natural-co-infection-of-pigs-with-african-swine-fever-virus-and-porcine-reproductive-and-respiratory-syndrome-virus-in-india
#17
JOURNAL ARTICLE
Swaraj Rajkhowa, Joyshikh Sonowal, Seema Rani Pegu, Gyanendra Singh Sanger, Rajib Deb, Pranab Jyoti Das, Juwar Doley, Souvik Paul, Vivek Kumar Gupta
Porcine reproductive and respiratory syndrome (PRRS) and African swine fever (ASF) are economically important diseases of pigs throughout the world. During an outbreak, all age groups of animals except piglets < 1 month of age were affected with symptoms of high fever, cutaneous hemorrhages, vomition with blood, diarrhea, poor appetite, ataxia, and death. The outbreak was confirmed by the detection of the N gene of the porcine reproductive and respiratory syndrome virus (PRRSV) and the VP72 gene of the African swine fever virus (ASFV) by PCR in representative blood samples from affected pigs followed by Sanger sequencing...
December 2, 2023: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://read.qxmd.com/read/38029161/molecular-diagnostic-assay-for-pre-harvest-detection-of-tilletia-indica-infection-in-wheat-plants
#18
JOURNAL ARTICLE
Prem Lal Kashyap, Sudheer Kumar, Ravi Shekhar Kumar, Anju Sharma, Annie Khanna, Shubham Raj, Poonam Jasrotia, Gyanendra Singh
The current study describes a new diagnostic method for the rapid and accurate detection of Tilletia indica , the pathogen accountable for causing Karnal bunt (KB) disease in wheat. This method uses quantitative real-time polymerase chain reaction (qPCR) and a primer set derived from glyceraldehyde 3-phosphate dehydrogenase (GAPDH) gene of T. indica to identify the presence of the pathogen. The qPCR assay using this primer set was found highly sensitive, with a limit of detection (LOD) value of 4 pg of T. indica DNA...
2023: Frontiers in Microbiology
https://read.qxmd.com/read/38023890/genetic-enhancement-of-okra-abelmoschus-esculentus-l-moench-germplasm-through-wide-hybridization
#19
JOURNAL ARTICLE
A Suma, K Joseph John, Kangila Venkataramana Bhat, Madhavan Latha, Chakkamadathil Jayasundaran Lakshmi, Mottaiyan Pitchaimuthu, V A M Nissar, Polavakkalipalayam Palanisamy Thirumalaisamy, Chitra Devi Pandey, Sushil Pandey, Ashok Kumar, Raj Kumar Gautam, Gyanendra Pratap Singh
INTRODUCTION: The introgression of genetic material from one species to another through wide hybridization and repeated back-crossing, plays an important role in genetic modification and enriching the cultivated gene-pool with novel genetic variations. Okra ( Abelmoschus esculentus [(L.) Moench)] is a popular vegetable crop with high dietary fibre and protein, rich in essential amino acids, lysine and tryptophan. The wild Abelmoschus genepool has many desirable traits like ornamental value, short internodal length, more number of productive branches, extended bearing, perennation tendency, reduced fruit length (more consumer preferred trait), high mucilage content (medicinal value), abiotic stress tolerances such as drought, high temperature and biotic stress resistances such as okra Yellow Vein Mosaic Virus (YVMV) and Enation Leaf Curl Virus (ELCV) diseases...
2023: Frontiers in Plant Science
https://read.qxmd.com/read/37975911/meta-qtl-analysis-in-wheat-progress-challenges-and-opportunities
#20
REVIEW
Divya Sharma, Anita Kumari, Priya Sharma, Anupma Singh, Anshu Sharma, Zahoor Ahmad Mir, Uttam Kumar, Sofora Jan, M Parthiban, Reyazul Rouf Mir, Pradeep Bhati, Anjan Kumar Pradhan, Aakash Yadav, Dwijesh Chandra Mishra, Neeraj Budhlakoti, Mahesh C Yadav, Kiran B Gaikwad, Amit Kumar Singh, Gyanendra Pratap Singh, Sundeep Kumar
Wheat, an important cereal crop globally, faces major challenges due to increasing global population and changing climates. The production and productivity are challenged by several biotic and abiotic stresses. There is also a pressing demand to enhance grain yield and quality/nutrition to ensure global food and nutritional security. To address these multifaceted concerns, researchers have conducted numerous meta-QTL (MQTL) studies in wheat, resulting in the identification of candidate genes that govern these complex quantitative traits...
November 17, 2023: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
keyword
keyword
116049
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.