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Plasma rich in platelets

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https://www.readbyqxmd.com/read/28317389/prp-for-degenerative-cartilage-disease
#1
Lior Laver, Niv Marom, Lad Dnyanesh, Omer Mei-Dan, João Espregueira-Mendes, Alberto Gobbi
OBJECTIVE: To explore the utilization of platelet-rich plasma (PRP) for degenerative cartilage processes and evaluate whether there is sufficient evidence to better define its potential effects. DESIGN: Systematic literature reviews were conducted in PubMed/MEDLINE and Cochrane electronic databases till May 2015, using the keywords "platelet-rich plasma OR PRP OR autologous conditioned plasma OR ACP AND cartilage OR chondrocyte OR chondrogenesis OR osteoarthritis (OA) OR arthritis...
September 1, 2016: Cartilage
https://www.readbyqxmd.com/read/28315407/controlled-delivery-of-platelet-derived-proteins-enhances-porcine-wound-healing
#2
Daniel W Long, Noah R Johnson, Eric M Jeffries, Hidetaka Hara, Yadong Wang
Platelet-rich plasma (PRP) is widely used for many clinical indications including wound healing due to the high concentrations of growth factors. However, the short half-life of these therapeutic proteins requires multiple large doses, and their efficacy is highly debated among clinicians. Here we report a method of protecting these proteins and releasing them in a controlled manner via a heparin-based coacervate delivery vehicle to improve wound healing in a porcine model. Platelet-derived proteins incorporated into the coacervate were protected and slowly released over 3weeks in vitro...
March 14, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28314112/can-mesenchymal-stem-cells-pretreated-with-platelet-rich-plasma-modulate-tissue-remodeling-in-a-rat-burn
#3
Hanan Hosni, Laila A Rashed, Soheir Mahfouz, Rania Elsayed Hussein, Marwa Alkaffas, Shaimaa Mostafa, Azza Abusree
AIM: To study the effect of PRP on BM-MSCs proliferation and to investigate their role on healing of experimental burn injury and possible mechanism of action. METHOD: Our work divided into in vitro and in vivo studies. In vitro study included,: MSCs and MSCs treated with PRP. TGF-β level and cell proliferation were assesed. In vivo study, 72 rats divided equally into 6 groups: control, burn, burn with MSCs, burn with PRP, burn with both MSCs and PRP and burn with MSCs pretreated with PRP...
March 17, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28303876/-ultrasonic-examination-of-the-breast-adipose-grafts-after-mammoplasty
#4
E P Fisenko, O I Startseva, D V Mel'nikov, A S Zakharenko, K A Kirillova, A G Ivanova, E D Pishchikova
AIM: To present the results of PRP-adipose grafts implanatation. MATERIAL AND METHODS: The study included 25 patients after transplantation of autologous adipose tissue. Autotransplantation was performed to correct volume defects of breast and to restore lost volume after polyacrylamide gel removal in 4 patients; after mastectomy in 6 cases; after complicated replacement using silicone endoprostheses in 11 patients; after previous reduction in 2 cases; after augmentation mammoplasty in 2 cases...
2017: Khirurgiia
https://www.readbyqxmd.com/read/28302625/silencing-of-anticoagulant-protein-c-evokes-low-incident-but-spontaneous-atherothrombosis-in-apolipoprotein-e-deficient-mice
#5
Amber B Ouweneel, Marco Heestermans, Robin A F Verwilligen, Marion J J Gijbels, Pieter H Reitsma, Miranda van Eck, Bart J M van Vlijmen
OBJECTIVE: Murine atherosclerosis models do not spontaneously develop atherothrombotic complications. We investigated whether disruption of natural anticoagulation allows preexisting atherosclerotic plaques to progress toward an atherothrombotic phenotype. APPROACH AND RESULTS: On lowering of plasma protein C levels with small interfering RNA (siProc) in 8-week Western-type diet-fed atherosclerotic apolipoprotein E-deficient mice, one out of 4 mice displayed a large, organized, and fibrin- and leukocyte-rich thrombus on top of an advanced atherosclerotic plaque located in the aortic root...
March 16, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28301205/intratendon-delivery-of-leukocyte-poor-platelet-rich-plasma-improves-healing-compared-with-leukocyte-rich-platelet-rich-plasma-in-a-rabbit-achilles-tendinopathy-model
#6
Ruijian Yan, Yanjia Gu, Jisheng Ran, Yejun Hu, Zefeng Zheng, Mengfeng Zeng, Boonchin Heng, Xiao Chen, Zi Yin, Weishan Chen, Weiliang Shen, Hongwei Ouyang
BACKGROUND: Chronic tendinopathy is a commonly occurring clinical problem that affects both athletes and inactive middle-aged patients. Although some studies have shown that different platelet-rich plasma (PRP) preparations could exert various therapeutic effects in vitro, the role of leukocytes in PRP has not yet been defined under tendinopathy conditions in vivo. PURPOSE: This study compared the effects of the intratendon delivery of leukocyte-poor PRP (Lp-PRP) versus leukocyte-rich PRP (Lr-PRP) in a rabbit chronic tendinopathy model in vivo...
March 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28296518/effect-of-platelet-rich-plasma-on-rat-achilles-tendon-healing-is-related-to-microbiota
#7
Franciele Dietrich, Malin Hammerman, Parmis Blomgran, Love Tätting, Vinicius Faccin Bampi, Jefferson Braga Silva, Per Aspenberg
Background and purpose - In 3 papers in Acta Orthopaedica 10 years ago, we described that platelet-rich plasma (PRP) improves tendon healing in a rat Achilles transection model. Later, we found that microtrauma has similar effects, probably acting via inflammation. This raised the suspicion that the effect ascribed to growth factors within PRP could instead be due to unspecific influences on inflammation. While testing this hypothesis, we noted that the effect seemed to be related to the microbiota. Material and methods - We tried to reproduce our old findings with local injection of PRP 6 h after tendon transection, followed by mechanical testing after 11 days...
March 15, 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/28296243/measurement-of-platelet-aggregation-independent-of-patient-platelet-count-a-flow-cytometric-approach
#8
Pernille Just Vinholt, Henrik Frederiksen, Anne-Mette Hvas, Ulrik Sprogøe, Christian Nielsen
BACKGROUND: Methods for testing platelet aggregation in thrombocytopenia are missing. OBJECTIVE: To establish a flow cytometric test of in vitro platelet aggregation independent of the patient platelet count and examined the association of aggregation with bleeding history in thrombocytopenic patients. PATIENTS/METHODS: We established a flow cytometric assay of platelet aggregation and measured samples from healthy individuals pre-incubated with antiplatelet drugs and samples from two patients with inherited platelet disorders...
March 15, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28293429/influence-of-nonsteroidal-anti-inflammatory-drugs-on-aspirin-s-antiplatelet-effects-and-suggestion-of-the-most-suitable-time-for-administration-of-both-agents-without-resulting-in-interaction
#9
Kenta Shibata, Yuuki Akagi, Naofumi Nozawa, Hitoshi Shimomura, Takao Aoyama
BACKGROUND: Low-dose aspirin irreversibly inhibits platelet cyclooxygenase-1 (COX-1) and suppresses platelet aggregation. It is effective for secondary prevention of cardiovascular events. Because nonsteroidal anti-inflammatory drugs (NSAIDs) reversibly bind with COX-1, the antiplatelet effects of aspirin may be suppressed when NSAIDs are co-administered. This interaction could be avoided by avoiding simultaneous administration; however, the minimum interval that should separate the administration of aspirin and loxoprofen is not well known...
2017: Journal of Pharmaceutical Health Care and Sciences
https://www.readbyqxmd.com/read/28292729/pre-analytical-effects-of-pneumatic-tube-system-transport-on-routine-haematology-and-coagulation-tests-global-coagulation-assays-and-platelet-function-assays
#10
Sandra Le Quellec, Mickaël Paris, Christophe Nougier, Frédéric Sobas, Lucia Rugeri, Sandrine Girard, Jean-Claude Bordet, Claude Négrier, Yesim Dargaud
INTRODUCTION: Pneumatic tube system (PTS) in hospitals is commonly used for the transport of blood samples to clinical laboratories, as it is rapid and cost-effective. The aim was to compare the effects on haematology samples of a newly acquired ~2km-long PTS that links 2 hospitals with usual transport (non-pneumatic tube system, NPTS). METHODS: Complete blood cell count, routine coagulation assays, platelet function tests (PFT) with light-transmission aggregometry and global coagulation assays including ROTEM® and thrombin generation assay (TGA) were performed on blood samples from 30 healthy volunteers and 9 healthy volunteers who agreed to take aspirin prior to blood sampling...
December 28, 2016: Thrombosis Research
https://www.readbyqxmd.com/read/28291948/eccentric-training-for-tendon-healing-after-acute-lesion-a-rat-model
#11
Jean-François Kaux, Vincent Libertiaux, Pierre Leprince, Marianne Fillet, Vincent Denoel, Clémence Wyss, Christelle Lecut, André Gothot, Caroline Le Goff, Jean-Louis Croisier, Jean-Michel Crielaard, Pierre Drion
BACKGROUND: The tendon is a dynamic entity that remodels permanently. Platelet-rich plasma (PRP) injection has been shown to have a beneficial effect on tendon healing after lesion in rats. Furthermore, eccentric exercise seems to improve the mechanical quality of the tendon. HYPOTHESIS: A combination of PRP injection and eccentric training might be more effective than either treatment alone. STUDY DESIGN: Controlled laboratory study. METHODS: Adult male rats were anesthetized, an incision was performed in the middle of their left patellar tendon and an injection of physiological fluid (PF) or homologous PRP was randomly made at the lesion level...
March 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28286383/the-efficacy-of-platelets-rich-plasma-injection-in-the-superior-joint-space-of-the-tempromandibular-joint-guided-by-ultra-sound-in-patients-with-non-reducing-disk-displacement
#12
Ra'ed M Ayoub Al-Delayme, Shefaa H Alnuamy, Firas Taha Hamid, Tariq Jassim Azzamily, Salah AbdulMahdy Ismaeel, R Sammir, M Hadeel, Jafaar Nabeel, R Shwan, Shahad Jamal Alfalahi, Alaa Yasin
OBJECTIVE: The objective of this study was to determine average improvement during the rest and active mouth opening after ultrasound guided platelets rich plasma injection in the tempromandibular superior joint space for the patients complaining from non-reducing disk displacement. PATIENTS AND METHODS: Thirty-four patients with non-reducing disk displacement underwent guided ultrasound injection of platelet rich plasma to the upper joint space. The extent of maximal mouth opening, chewing efficiency, sound intensity of the TMJ, and tenderness of the TMJ and the masticatory muscles at rest, motion and mastication were thoroughly assessed at the beginning of the study and scheduled for next follow-up at 1st, 3rd, and 6th months...
March 2017: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/28282030/platelet-rich-plasma-for-regeneration-of-neural-feedback-pathways-around-dental-implants-a-concise-review-and-outlook-on-future-possibilities
#13
REVIEW
Yan Huang, Michael M Bornstein, Ivo Lambrichts, Hai-Yang Yu, Constantinus Politis, Reinhilde Jacobs
Along with the development of new materials, advanced medical imaging and surgical techniques, osseointegrated dental implants are considered a successful and constantly evolving treatment modality for the replacement of missing teeth in patients with complete or partial edentulism. The importance of restoring the peripheral neural feedback pathway and thus repairing the lack of periodontal mechanoreceptors after tooth extraction has been highlighted in the literature. Nevertheless, regenerating the nerve fibers and reconstructing the neural feedback pathways around osseointegrated implants remain a challenge...
March 10, 2017: International Journal of Oral Science
https://www.readbyqxmd.com/read/28277063/quantification-of-growth-factors-in-different-platelet-concentrates
#14
Jing Qiao, Na An, Xiangying Ouyang
Concentrated growth factor (CGF), a new generation of platelet concentrate product, appears to have more abundant growth factors because of its special centrifugation process. However, there are few studies supporting this. This study was designed to evaluate the contents of major growth factors in CGF and compare them with those found in PRP (platelet-rich plasma) and PRF (platelet-rich fibrin). PRP, PRF, and CGF were obtained from the same samples of peripheral blood. Concentrations of five representative growth factors in platelets were measured with enzyme-linked immunosorbent assay (ELISA): platelet-derived growth factor-BB (PDGF-BB), transforming growth factor β-1 (TGF-β1), insulin-like growth factor-1 (IGF-1), vascular endothelial growth factor (VEGF), and basic fibroblast growth factor (bFGF)...
February 21, 2017: Platelets
https://www.readbyqxmd.com/read/28276986/platelet-rich-plasma-versus-steroid-on-lateral-epicondylitis-meta-analysis-of-randomized-clinical-trials
#15
Bobin Mi, Guohui Liu, Wu Zhou, Huijuan Lv, Yi Liu, Qipeng Wu, Jing Liu
OBJECTIVES: Lateral epicondylitis (LE) is a common tendinopathy for which an effective treatment is still unknown. The purpose of this meta-analysis was to compare the effectiveness of platelet rich plasma (PRP) vs steroid in reducing pain and improving function of the elbow in the treatment of LE. METHODS: A systematic search of the literature was conducted to identify related articles published from January 1980 to September 2016 in Pubmed, Embase, the Cochrane Library and SpringerLink...
March 3, 2017: Physician and Sportsmedicine
https://www.readbyqxmd.com/read/28276640/prospective-review-of-mesenchymal-stem-cells-differentiation-into-osteoblasts
#16
REVIEW
Priyanka Garg, Matthew M Mazur, Amy C Buck, Meghan E Wandtke, Jiayong Liu, Nabil A Ebraheim
Stem cell research has been a popular topic in the past few decades. This review aims to discuss factors that help regulate, induce, and enhance mesenchymal stem cell (MSC) differentiation into osteoblasts for bone regeneration. The factors analyzed include bone morphogenic protein (BMP), transforming growth factor β (TGF-β), stromal cell-derived factor 1 (SDF-1), insulin-like growth factor type 1 (IGF-1), histone demethylase JMJD3, cyclin dependent kinase 1 (CDK1), fucoidan, Runx2 transcription factor, and TAZ transcriptional coactivator...
March 9, 2017: Orthopaedic Surgery
https://www.readbyqxmd.com/read/28273894/six-month-efficacy-of-platelet-rich-plasma-for-carpal-tunnel-syndrome-a-prospective-randomized-single-blind-controlled-trial
#17
Yung-Tsan Wu, Tsung-Yen Ho, Yu-Ching Chou, Ming-Jen Ke, Tsung-Ying Li, Guo-Shu Huang, Liang-Cheng Chen
Recently, a few small reports with short follow-up period have shown clinical benefits of platelet-rich plasma (PRP) for peripheral neuropathy including one pilot study and one small, non-randomized trial in patients with carpal tunnel syndrome (CTS). Therefore, we conducted a randomized, single-blind, controlled trial to assess the 6-month effect of PRP in patients with CTS. Sixty patients with unilateral mild-to-moderate CTS were randomized into two groups of 30, namely the PRP and control groups. In the PRP group, patients were injected with one dose of 3 mL of PRP using ultrasound guidance and the control group received a night splint through the study period...
December 2017: Scientific Reports
https://www.readbyqxmd.com/read/28273236/three-dimensional-structure-and-cytokine-distribution-of-platelet-rich-fibrin
#18
Meng-Yi Bai, Ching-Wei Wang, Jyun-Yi Wang, Ming-Fang Lin, Wing P Chan
OBJECTIVES: Previous reports have revealed that several cytokines (including platelet-derived growth factor-BB, transforming growth factors-β1 and insulin-like growth factor-1) can enhance the rate of bone formation and synthesis of extracellular matrix in orthopaedics or periodontology. This study aimed to determine the concentration of cytokines within platelet-rich fibrin microstructures and investigate whether there are differences in the different portions of platelet-rich fibrin, which has implications for proper clinical use of platelet-rich fibrin gel...
February 1, 2017: Clinics
https://www.readbyqxmd.com/read/28271918/platelet-rich-plasma-for-treatment-of-nonscarring-hair-loss-systematic-review-of-literature
#19
Azin Ayatollahi, Hamed Hosseini, Jaleh Gholami, Babak Mirminachi, FaridHossein Firooz, Alireza Firooz
BACKGROUND: Although there are many studies showing the role of platelet rich plasma (PRP) in bone grafts, teeth osteosynthesis, and wound healing, there have been little peer reviewed studies about the safety and efficacy of PRP application in the treatment of hair loss. MATERIALS AND METHODS: In this systematic review, we searched Ovid Medline, Scopus and Web of Knowledge till November 2015 for human studies evaluating the efficacy of PRP for the treatment of noncicatricial alopecia...
March 8, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28269759/effects-of-different-concentrations-of-platelet-rich-plasma-and-platelet-poor-plasma-on-vitality-and-differentiation-of-autologous-adipose-tissue-derived-stem-cells
#20
Oliver Felthaus, Lukas Prantl, Mona Skaff-Schwarze, Silvan Klein, Alexandra Anker, Marco Ranieri, Britta Kühlmann
BACKGROUND: Autologous fat grafts and adipose-derived stem cells (ASCs) can be used to treat soft tissue defects. However, the results are inconsistent and sometimes comprise tissue resorption and necrosis. This might be due to insufficient vascularization. Platelet-rich plasma (PRP) is a source of concentrated autologous platelets. The growth factors and cytokines released by platelets can facilitate angiogenesis. The simultaneous use of PRP might improve the regeneration potential of fat grafts...
February 28, 2017: Clinical Hemorheology and Microcirculation
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