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https://www.readbyqxmd.com/read/27846901/a-method-for-automated-pathogenic-content-estimation-with-application-to-rheumatoid-arthritis
#1
Xiaoyuan Zhou, Christine Nardini
BACKGROUND: Sequencing technologies applied to mammals' microbiomes have revolutionized our understanding of health and disease. Hence, to assess diseases' progression as well as therapies longterm effects, the impact of maladies and drugs on the gut-intestinal (GI) microbiome has to be evaluated. Typical metagenomic analyses are run to associate to a condition (disease, therapy, diet) a pool of bacteria, whose eubiotic/dysbiotic potential is assessed either by α-diversity, a measure of the varieties populating the microbiome, or by Firmicutes to Bacteroides ratio, associated to systemic inflammation, and finally by manual and direct inspection of bacteria's biological functions, when known...
November 15, 2016: BMC Systems Biology
https://www.readbyqxmd.com/read/27677914/effect-of-glycemic-index-of-a-pre-exercise-meal-on-endurance-exercise-performance-a-systematic-review-and-meta-analysis
#2
Catriona A Burdon, Inge Spronk, Hoi Lun Cheng, Helen T O'Connor
BACKGROUND: Low glycemic index (GI) pre-exercise meals may enhance endurance performance by maintaining euglycemia and altering fuel utilization. However, evidence for performance benefits is equivocal. OBJECTIVE: To evaluate the effect of a low GI (LGI) versus a high GI (HGI) pre-exercise meal on endurance performance using meta-analyses. METHODS: Data sources included MEDLINE, SPORTDiscus, AUSPORT, AusportMed, Web of Science, and Scopus...
September 28, 2016: Sports Medicine
https://www.readbyqxmd.com/read/27616759/il-1%C3%AE-promotes-tubulointerstitial-injury-in-%C3%A2-mpo-anca-associated-glomerulonephritis%C3%A2
#3
Manabu Tashiro, Yoshie Sasatomi, Renya Watanabe, Maho Watanabe, Katsuhisa Miyake, Yasuhiro Abe, Tetsuhiko Yasuno, Kenji Ito, Naoko Ueki, Aki Hamauchi, Ritsuya Noda, Satoshi Hisano, Hitoshi Nakashima
BACKGROUND: It is widely accepted that tubulointerstitial injury (TII) is caused by glomerular injury (GI) in glomerular diseases. Glomerular endocapillary inflammation may result in crescent formation and exuded protein leakage, which may induce TII in antineutrophil cytoplasmic antibody-associated glomerulonephritis (ANCAGN). However, some reports have indicated a glomerulonephritis-independent mechanism of TII in ANCAGN. The aim of this study was to determine the principle cytokines correlated with TII severity and to elucidate a characteristic mechanism for TII in ANCAGN...
October 2016: Clinical Nephrology
https://www.readbyqxmd.com/read/27609817/integrated-myocardial-perfusion-imaging-diagnostics-improve-detection-of-functionally-significant-coronary-artery-stenosis-by-13n-ammonia-positron-emission-tomography
#4
Joo Myung Lee, Chee Hae Kim, Bon-Kwon Koo, Doyeon Hwang, Jonghanne Park, Jinlong Zhang, Yaliang Tong, Ki-Hyun Jeon, Ji-In Bang, Minseok Suh, Jin Chul Paeng, Gi Jeong Cheon, Sang-Hoon Na, Jung-Min Ahn, Seung-Jung Park, Hyo-Soo Kim
BACKGROUND: Recent evidence suggests that the diagnostic accuracy of myocardial perfusion imaging is improved by quantifying stress myocardial blood flow (MBF) in absolute terms. We evaluated a comprehensive quantitative (13)N-ammonia positron emission tomography ((13)NH3-PET) diagnostic panel, including stress MBF, coronary flow reserve (CFR), and relative flow reserve (RFR) in conjunction with relative perfusion defect (PD) assessments to better detect functionally significant coronary artery stenosis...
September 2016: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27600643/endoscopic-imaging-in-the-management-of-gastroenteropancreatic-neuroendocrine-tumors
#5
Rinaldo Pellicano, Sharmila Fagoonee, Fiorella Altruda, Mauro Bruno, Giorgio M Saracco, Claudio De Angelis
Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are a heterogeneous group of tumors deriving from the gastrointestinal (GI) neuroendocrine system. Since these neoplasms are usually very small, located deeply within the retroperitoneum or into an extramucosal site of the GI tract and, lastly, because they may be multi-sited, radiological imaging modalities, in combination with endoscopy, are the diagnostic workhorses in patients with GEP-NETs. Endoscopic approach is useful for detection, bioptic diagnosis and curative resection of small GEP-NETs of stomach, duodenum, jejuno-ileum, and colon-rectum...
December 2016: Minerva Endocrinologica
https://www.readbyqxmd.com/read/27570419/management-of-gastric-and-duodenal-neuroendocrine-tumors
#6
REVIEW
Yuichi Sato, Satoru Hashimoto, Ken-Ichi Mizuno, Manabu Takeuchi, Shuji Terai
Gastrointestinal neuroendocrine tumors (GI-NETs) are rare neoplasms, like all NETs. However, the incidence of GI-NETS has been increasing in recent years. Gastric NETs (G-NETs) and duodenal NETs (D-NETs) are the common types of upper GI-NETs based on tumor location. G-NETs are classified into three distinct subgroups: type I, II, and III. Type I G-NETs, which are the most common subtype (70%-80% of all G-NETs), are associated with chronic atrophic gastritis, including autoimmune gastritis and Helicobacter pylori associated atrophic gastritis...
August 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27342825/the-multidisciplinary-approach-to-gi-cancer-results-in-change-of-diagnosis-and-management-of-patients-multidisciplinary-care-impacts-diagnosis-and-management-of-patients
#7
Cheryl Meguid, Richard D Schulick, Tracey E Schefter, Christopher H Lieu, Megan Boniface, Nicole Williams, Jon D Vogel, Csaba Gajdos, Martin McCarter, Barish H Edil
BACKGROUND: The multidisciplinary approach to GI cancer is becoming more widespread as a result of multimodality therapy. At the University of Colorado Hospital (UCH), we utilize a formal multidisciplinary approach through specialized clinics across a variety of settings, including pancreas and biliary cancer, esophageal and gastric cancer, liver cancer and neuroendocrine tumors (NET), and colorectal cancer. Patients with these suspected diagnoses are seen in a multidisciplinary clinic...
June 24, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27330538/liver-metastasis-of-gastrointestinal-neuroendocrine-tumors-a-single-center-experience
#8
Bita Geramizadeh, Ali Kashkooe, Seyed Ali Malekhosseini
BACKGROUND: Gastrointestinal neuroendocrine tumors (GI-NETs) are potentially malignant tumors, and their most common location of metastasis is the liver. OBJECTIVES: In this report, we will describe our experience with some clinical and pathologic findings of hepatic metastasis in a group of cases of GI-NETs at the largest referral center of GI and liver diseases in south Iran. MATERIALS AND METHODS: In this four-year study (2011 - 2014), all GI and liver NETs were extracted from the pathology files of hospitals affiliated with Shiraz University of Medical Sciences...
May 2016: Hepatitis Monthly
https://www.readbyqxmd.com/read/27327193/ileal-carcinoid-tumors-small-size-belies-deadly-intent-high-rate-of-nodal-metastasis-in-tumors-%C3%A2-1-cm-in-size
#9
Joanna C Walsh, David F Schaeffer, Richard Kirsch, Aaron Pollett, Marco Manzoni, Robert H Riddell, Luca Albarello
Neuroendocrine tumors (NETs) account for 2% of tumors of the gastrointestinal tract, most occurring in the small intestine. A size of 2 cm is generally regarded as a cut-off point for risk of lymph node metastasis in intestinal neuroendocrine tumors in the absence of other high-risk features; however, metastatic disease has been reported in 12% of tumors of the jejunum and ileum measuring 1 cm or less. Archives from 2 institutions were searched for ileal NETs measuring 1 cm or less, and selected data were recorded...
October 2016: Human Pathology
https://www.readbyqxmd.com/read/27326246/genomic-profiling-of-metastatic-gastroenteropancreatic-neuroendocrine-tumor-gep-net-patients-in-the-personalized-medicine-era
#10
Seung Tae Kim, Su Jin Lee, Se Hoon Park, Joon Oh Park, Ho Yeong Lim, Won Ki Kang, Jeeyun Lee, Young Suk Park
BACKGROUND: We have conducted molecular profiling through a high-throughput molecular test as part of our clinical practice for patients with advanced gastrointestinal (GI) cancer or rare cancers including gastroenteropancreatic neuroendocrine tumors (GEP-NETs). Herein, we report on the molecular characterization of 14 metastatic GEP-NET patients. METHODS: We conducted the Ion AmpliSeq Cancer Hotspot Panel v2 (detecting 2,855 oncogenic mutations in 50 commonly mutated genes) and nCounter Copy Number Variation Assay, which was designed with 21 genes based on available targeted agents, as a high throughput genomic platform in 14 patients with metastatic GEP-NETs...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27304072/endoscopic-imaging-in-the-management-of-gastroenteropancreatic-neuroendocrine-tumors-update-for-endocrinologists
#11
Rinaldo Pellicano, Sharmila Fagoonee, Fiorella Altruda, Mauro Bruno, Giorgio M Saracco, Claudio DE Angelis
Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are a heterogeneous group of tumors deriving from the gastrointestinal (GI) neuroendocrine system. Since these neoplasms are usually very small, located deeply within the retroperitoneum or into an extramucosal site of the GI tract and, lastly, because they may be multi-sited, radiological imaging modalities, in combination with endoscopy, are the diagnostic workhorses in patients with GEP-NETs. Endoscopic approach is useful for detection, bioptic diagnosis and curative resection of small GEP-NETs of stomach, duodenum, jejuno-ileum, and colon-rectum...
June 15, 2016: Minerva Endocrinologica
https://www.readbyqxmd.com/read/27236421/diagnosis-and-management-of-gastrointestinal-neuroendocrine-tumors-an-evidence-based-canadian-consensus
#12
REVIEW
Simron Singh, Sylvia L Asa, Chris Dey, Hagen Kennecke, David Laidley, Calvin Law, Timothy Asmis, David Chan, Shereen Ezzat, Rachel Goodwin, Ozgur Mete, Janice Pasieka, Juan Rivera, Ralph Wong, Eva Segelov, Daniel Rayson
The majority of neuroendocrine tumors originate in the digestive system and incidence is increasing within Canada and globally. Due to rapidly evolving evidence related to diagnosis and clinical management, updated guidance on the diagnosis and treatment of gastrointestinal neuroendocrine tumors (GI-NETs) are of clinical importance. Well-differentiated GI-NETs may exhibit indolent clinical behavior and are often metastatic at diagnosis. Some NET patients will develop secretory disease requiring symptom control to optimize quality of life and clinical outcomes...
June 2016: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/27168106/everolimus-for-advanced-progressive-nonfunctional-neuroendocrine-tumors-net-of-the-gastrointestinal-gi-tract-efficacy-and-safety-from-a-radiant-4-subgroup-analysis
#13
(no author information available yet)
No abstract text is available yet for this article.
May 2016: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/27148486/notch-signaling-in-neuroendocrine-tumors
#14
REVIEW
Judy S Crabtree, Ciera S Singleton, Lucio Miele
Carcinoids and neuroendocrine tumors (NETs) are a heterogeneous group of tumors that arise from the neuroendocrine cells of the GI tract, endocrine pancreas, and the respiratory system. NETs remain significantly understudied with respect to molecular mechanisms of pathogenesis, particularly the role of cell fate signaling systems such as Notch. The abundance of literature on the Notch pathway is a testament to its complexity in different cellular environments. Notch receptors can function as oncogenes in some contexts and tumor suppressors in others...
2016: Frontiers in Oncology
https://www.readbyqxmd.com/read/27128301/recent-updates-on-neuroendocrine-tumors-from-the-gastrointestinal-and-pancreatobiliary-tracts
#15
Joo Young Kim, Seung-Mo Hong
CONTEXT: -Gastrointestinal (GI) and pancreatobiliary tracts contain a variety of neuroendocrine cells that constitute a diffuse endocrine system. Neuroendocrine tumors (NETs) from these organs are heterogeneous tumors with diverse clinical behaviors. Recent improvements in the understanding of NETs from the GI and pancreatobiliary tracts have led to more-refined definitions of the clinicopathologic characteristics of these tumors. Under the 2010 World Health Organization classification scheme, NETs are classified as grade (G) 1 NETs, G2 NETs, neuroendocrine carcinomas, and mixed adenoneuroendocrine carcinomas...
May 2016: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/27089107/utilization-of-fecal-occult-blood-test-in-the-acute-hospital-setting-and-its-impact-on-clinical-management-and-outcomes
#16
S Mosadeghi, H Ren, J Catungal, I Yen, B Liu, R J Wong, T Bhuket
BACKGROUND: Despite lack of evidence supporting the use of fecal occult blood test (FOBT) in the acute hospital setting, FOBT is commonly used in the inpatient setting for reasons other than colorectal cancer (CRC) screening. AIMS: To evaluate practice trends in utilizing FOBT on inpatients and its impact on affecting clinical management and outcomes. MATERIALS AND METHODS: A cross-sectional study of consecutive adult patients undergoing FOBT from January 1, 2011 to December 31, 2011 during an acute medical admission at a large urban safety net hospital was performed...
April 2016: Journal of Postgraduate Medicine
https://www.readbyqxmd.com/read/27082572/effectiveness-of-endoscopic-treatment-for-gastrointestinal-neuroendocrine-tumors-a-retrospective-study
#17
Weili Sun, Siyuan Wu, Xiao Han, Chuanhua Yang
Several recent studies have explored efficacy and safety of different endoscopic treatments for gastrointestinal neuroendocrine tumors (GI-NETs). However, there is no definitive consensus regarding the best endoscopic approach for GI-NETs treatment. Therefore, the present study was conducted to investigate the application of various endoscopic techniques for the treatment of GI-NETs according to the previous conclusions and to summarize the optimal endoscopic modalities for GI-NETs. Ninety-eight patients with 100 GI-NETs removed by endoscopic therapies were reviewed...
April 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27067147/correlations-between-household-occupancy-and-malaria-vector-biting-risk-in-rural-tanzanian-villages-implications-for-high-resolution-spatial-targeting-of-control-interventions
#18
Emmanuel W Kaindoa, Gustav Mkandawile, Godfrey Ligamba, Louise A Kelly-Hope, Fredros O Okumu
BACKGROUND: Fine-scale targeting of interventions is increasingly important where epidemiological disease profiles depict high geographical stratifications. This study verified correlations between household biomass and mosquito house-entry using experimental hut studies, and then demonstrated how geographical foci of mosquito biting risk can be readily identified based on spatial distributions of household occupancies in villages. METHODS: A controlled 4 × 4 Latin square experiment was conducted in rural Tanzania, in which no, one, three or six adult male volunteers slept under intact bed nets, in experimental huts...
2016: Malaria Journal
https://www.readbyqxmd.com/read/27064573/aspirin-for-the-primary-prevention-of-cardiovascular-disease-and-colorectal-cancer-a-decision-analysis-for-the-u-s-preventive-services-task-force
#19
Steven P Dehmer, Michael V Maciosek, Thomas J Flottemesch, Amy B LaFrance, Evelyn P Whitlock
BACKGROUND: Evidence indicates that aspirin is effective for the primary prevention of cardiovascular disease (CVD) and colorectal cancer (CRC) but also increases the risk for gastrointestinal (GI) and cerebral hemorrhages. OBJECTIVE: To assess the net balance of benefits and harms from routine aspirin use across clinically relevant age, sex, and CVD risk groups. DESIGN: Decision analysis using a microsimulation model. DATA SOURCES: 3 systematic evidence reviews...
June 21, 2016: Annals of Internal Medicine
https://www.readbyqxmd.com/read/27033797/-diagnostic-analysis-for-52-cases-of-gastrointestinal-neuroendocrine-tumor
#20
Yi'nan Wang, Yuan Zhou, Heli Liu, Haiping Pei
OBJECTIVE: To investigate the clinical features, diagnosis, treatments and prognosis for gastrointestinal neuroendocrine tumors (GI-NETs).
 METHODS: Clincal data of 52 patients, who were diagnosed as GI-NETs between January 2004 and October 2014, were reviewed. The patients were divided into a local excision group (n=21) and a transabdominal excision group (n=30), and the major clinical features, treatment modalities and outcomes were analyzed.
 RESULTS: The clinical features of GI-NETs were nonspecific, and most of the clinical manifestation were local invasiveness...
March 28, 2016: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
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