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https://www.readbyqxmd.com/read/27922677/prx1-promotes-the-proliferation-and-migration-of-vascular-smooth-muscle-cells-in-a-tlr4-dependent-manner
#1
Zhicheng Zhu, Xiaomei Zheng, Dan Li, Tiance Wang, Rihao Xu, Hulin Piao, Kexiang Liu
The present study aimed to examine the effect of peroxiredocin 1 (Prx1) on vascular smooth muscle cell (VSMC) proliferation, invasion and migration abilities, and to examine the effect of Toll‑like receptor 4 (TLR4) gene silencing on VSMC proliferation, invasion and migration induced by the overexpression of Prx1. The expression of Prx1 in rats with vein graft intimal hyperplasia (IH) was detected using western blot analysis. In addition, VSMCs were retrovirally transfected to establish stable cell lines overexpressing Prx1...
December 6, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27919430/carbon-dioxide-insufflation-deflects-airborne-particles-from-an-open-surgical-wound-model
#2
P Kokhanenko, G Papotti, J E Cater, A C Lynch, J A van der Linden, C J T Spence
BACKGROUND: Surgical site infections remain a significant burden on healthcare systems and may benefit from new countermeasures. AIM: To assess the merits of open surgical wound CO2 insufflation via a gas diffuser to reduce airborne contamination, and to determine the distribution of CO2 in and over a wound. METHODS: An experimental approach with engineers and clinical researchers was employed to measure the gas flow pattern and motion of airborne particles in a model of an open surgical wound in a simulated theatre setting...
November 21, 2016: Journal of Hospital Infection
https://www.readbyqxmd.com/read/27910375/high-precision-measurement-of-magnetic-penetration-depth-in-superconducting-films
#3
X He, A Gozar, R Sundling, I Božović
The magnetic penetration depth (λ) in thin superconducting films is usually measured by the mutual inductance technique. The accuracy of this method has been limited by uncertainties in the geometry of the solenoids and in the film position and thickness, by parasitic coupling between the coils, etc. Here, we present several improvements in the apparatus and the method. To ensure the precise thickness of the superconducting layer, we engineer the films at atomic level using atomic-layer-by-layer molecular beam epitaxy...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27908581/sonodynamic-inactivation-of-gram-positive-and-gram-negative-bacteria-using-a-rose-bengal-antimicrobial-peptide-conjugate
#4
David Costley, Heather Nesbitt, Nigel Ternan, James Dooley, Ying-Ying Huang, Michael R Hamblin, Anthony P McHale, John F Callan
Combating antimicrobial resistance is one of the most serious public health challenges facing society today. The development of new antibiotics or alternative techniques that can help combat antimicrobial resistance is being prioritised by many governments and stakeholders across the globe. Antimicrobial photodynamic therapy is one such technique that has received considerable attention but is limited by the inability of light to penetrate through human tissue, reducing its effectiveness when used to treat deep-seated infections...
November 17, 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/27906854/a-bullet-lying-next-to-the-common-carotid-artery-in-the-neck-of-a-young-boy
#5
Gülpembe Bozkurt, Meltem Esen Akpinar, Özlem Ünsal, Berna Uslu Coşkun
Penetrating neck trauma is most commonly caused by firearm discharge, and is potentially very dangerous, being associated with a high risk of mortality. A 12-year-old patient with a recent history of a gunshot wound to the neck was evaluated in detail; a bullet was located in close proximity to the left common carotid artery. Neck exploration was performed and the foreign body was removed without any complications. The management of the patient is discussed, as are contemporary approaches to the treatment of penetrating neck trauma...
November 30, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27903839/the-effect-of-brain-tomography-findings-on-mortality-in-sniper-shot-head-injuries
#6
Çağdaş Can, M Bolatkale, A Sarıhan, Y Savran, A Ç Acara, M Bulut
OBJECTIVES: Penetrating gunshot head injuries have a poor prognosis and require prompt care. Brain CT is a routine component of the standard evaluation of head wounds and suspected brain injury. We aimed to investigate the effect of brain CT findings on mortality in gunshot head injury patients who were admitted to our emergency department (ED) from the Syrian Civil War. METHODS: The study group comprised patients who were admitted to the ED with gunshot brain injury...
November 30, 2016: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/27879614/getting-a-better-look-outcomes-of-laparoscopic-versus-transdiaphragmatic-pericardial-window-for-penetrating-thoracoabdominal-trauma-at-a-level-i-trauma-center
#7
Jamie E Anderson, Edgardo S Salcedo, Kacie M Rounds, Joseph M Galante
BACKGROUND: In penetrating thoracoabdominal trauma, it is necessary to evaluate both the pericardial fluid and the diaphragm directly. Transdiaphragmatic pericardial windows (TDWs) provide direct access to the pericardium and diaphragm but expose the patient to the risks of laparotomy. We hypothesize that transabdominal laparoscopic pericardial windows (LPWs) are a safe and effective alternative to TDWs in stable patients. METHODS: This is a retrospective observational study of stable patients with thoracoabdominal penetrating trauma at a level I trauma center between January 2007 and June 2015, comparing outcomes after TDW versus LPW...
December 2016: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/27878927/the-septin-protein-sep4-facilitates-host-infection-by-plant-fungal-pathogens-via-mediating-initiation-of-infection-structure-formation
#8
Hui-Qiang Feng, Gui-Hua Li, Du Shun-Wen, Song Yang, Xue-Qian Li, Paul de Figueiredo, Qing-Ming Qin
Many phytopathogenic fungi use infection structures (IFSs, i.e., appressoria and infection cushions) to penetrate host cuticles. However, the conserved mechanisms that mediate initiation of IFS formation in divergent pathogens upon sensing the presence of host plants remain obscure. Here, we demonstrate that a conserved septin gene SEP4 plays crucial roles in this process. Disruption of SEP4 in the plant gray mold fungus Botrytis cinerea completely blocked IFS formation and abolished the virulence of ΔBcsep4 mutants on unwounded hosts...
November 23, 2016: Environmental Microbiology
https://www.readbyqxmd.com/read/27858523/laparoscopic-assisted-approach-for-penetrating-abdominal-trauma-an-underutilized-technique
#9
Modise Z Koto, Oleh Y Matsevych, Colleen Aldous
INTRODUCTION: Diagnostic laparoscopy is well accepted in the management of penetrating abdominal trauma (PAT). Therapeutic laparoscopy, on the other hand, remains controversial. In patients with multiple hollow viscera injuries, laparoscopy is usually converted to laparotomy. We aim at describing the laparoscopic-assisted technique in the management of patients with PAT. Using our experience with laparoscopy, we tailored the technique to the setting of PAT. METHODS: The laparoscopic-assisted approach (LAA) was adapted to a trauma setting and prospectively evaluated...
November 18, 2016: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/27857932/the-neck-and-posterior-fossa-combined-penetrating-injury-a-case-report
#10
Hyun Jin Han, Jun Ho Jung, Chang Ki Hong, Yong Bae Kim
Here we report a case of penetrating neck injury to the posterior fossa that was shown, using high-resolution computed tomography (HRCT) and digital subtraction angiography (DSA), to involve no vascular injury. A 54-year-old man was brought to the emergency department after a penetrating injury to the left side of the posterior neck and occipital area with a knife. He was in an intoxicated state and could not communicate readily. On initial examination, his vital signs were stable and there was no active bleeding from the penetrating site...
October 2016: Korean Journal of Neurotrauma
https://www.readbyqxmd.com/read/27857653/immediate-tangential-excision-accelerates-wound-closure-but-does-not-reduce-scarring-of-mid-dermal-porcine-burns
#11
L K Macri, A J Singer, S A McClain, L Crawford, A Prasad, J Kohn, R A F Clark
Current evidence supports the use of excision to remove eschar from deep dermal and full-thickness burns. However, the role of excision of mid-dermal burns remains unclear. This study aimed to develop a porcine model that could produce reproducible middermal thermal burns that undergo tangential excision; and investigate the effects of immediate tangential excision (30 minutes postburn) on healing and scarring. An aluminum bar preheated in hot water (70°C) was applied for 20 or 30 s to produce a total of sixteen mid-dermal burns per pig on each of six pigs...
March 31, 2016: Annals of Burns and Fire Disasters
https://www.readbyqxmd.com/read/27856172/feasibility-of-selective-non-operative-management-for-penetrating-abdominal-trauma-in-france
#12
G Goin, D Massalou, T Bege, C Contargyris, J-P Avaro, G Pauleau, P Balandraud
INTRODUCTION: In France, non-operative management (NOM) is not the widely accepted treatment for penetrating wounds. The aim of our study was to evaluate the feasibility of NOM for the treatment of penetrating abdominal traumas at 3 hospitals in the Southeast of France. METHODOLOGY: Our study was multicentric and retroprospective from January, 2010 to September, 2013. Patients presenting with a penetrating abdominal stab wound (SW) or gunshot wound (GSW) were included in the study...
November 14, 2016: Journal of Visceral Surgery
https://www.readbyqxmd.com/read/27849319/traumatic-wound-dehiscence-after-penetrating-keratoplasty
#13
Özlem Barut Selver, Melis Palamar, Sait Eğrilmez, Ayşe Yağcı
BACKGROUND: The aim of this study was to evaluate risks and consequences of traumatic wound dehiscence after penetrating keratoplasty (PK). METHODS: Data regarding 34 eyes of 34 patients who were treated for traumatic wound dehiscence after PK between 1995 and 2014 were studied. Patient records were reviewed for type and time of insult, corrected distance visual acuity (CDVA), clinical presentation signs, operative method, and outcome. RESULTS: The interval between PK and trauma ranged from 1 month to 100 months, with median of 14 months...
September 2016: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/27847077/a-close-call-an-impacted-knife-injury-to-the-thorax
#14
Tim Kaufeld, Christian Zeckey, Steffen Marquardt, Christian Krettek, Axel Haverich, Igor Tudorache
A 21-year-old woman with a history of psychiatric treatment was admitted to the emergency department with self-inflicted stab wounds to the neck, chest, and abdomen as the result of a suicide attempt. Inspection showed a seemingly superficial cut at the jugular fossa. The patient's mother stated that one long ceramic kitchen bread knife was totally embedded in the right thorax. Further diagnostic measures showed the missing kitchen bread knife penetrating the right chest, with the path of insertion starting 2 cm above the right clavicle and the blade in contact with the right hilum and ending next to the seventh thoracic vertebra...
December 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27845963/internal-distraction-osteogenesis-with-piezosurgery-oblique-osteotomy-of-supraorbital-margin-of-frontal-bone-for-the-treatment-of-unilateral-coronal-synostosis
#15
Weimin Shen, Jie Cui, Jianbing Chen, Yi Ji, Liangliang Kong
PURPOSE: To assess the utility of internal distraction osteogenesis with Piezosurgery oblique osteotomy of supraorbital margin of frontal bone for the treatment of unilateral coronal synostosis and to study the outcome and complications of this procedure. Oblique osteotomy allows for entry into the cranial cavity, and along with parallel cut to the roof of the orbit, avoids the need to cut into the orbit which forms the frontal flap. METHODS: Oblique osteotomy was performed along the supraorbital rim to do a frontal suture of the glabella (ages of patients were less than 1 year) or on the opposite side of the supraorbital rim (ages of patients were older than 1 year) after performing a suturectomy of the effected coronal suture...
November 15, 2016: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/27823364/medical-management-of-spinal-epidural-empyema-in-five-dogs
#16
Susana R Monforte Monteiro, Antonella Gallucci, Nicolas Rousset, Paul M Freeman, Edward J Ives, Gualtiero Gandini, Nicolas Granger, An E Vanhaesebrouck
CASE DESCRIPTION 5 dogs were examined because of clinical signs of myelopathy, including signs of pain associated with the spinal region and rapidly progressive neurologic deficits. CLINICAL FINDINGS In all dogs, results of MRI were consistent with spinal epidural empyema. Concurrent infectious processes were identified at adjacent or distant sites in all dogs, including diskospondylitis, prostatitis, dermatitis, paraspinal infection following a penetrating injury, urinary tract infection, and pyothorax. Bacteria were isolated from 3 dogs; Escherichia coli was isolated from blood, urine, and prostatic wash samples from 1 dog; a Pasteurella sp was isolated from a percutaneous aspirate from an adjacent infected wound in a second dog; and a Corynebacterium sp was isolated from a thoracic fluid sample from a third dog...
November 15, 2016: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/27821826/-penetrating-injury-of-the-lung-with-a-glass-splinter
#17
Masahiro Yamada, Masami Abiko, Hirohisa Katoh, Makoto Endoh
A 62-year-old man got drunk and dived into the windowpane. He received lacerations on his face and incised wound at his right chest, and was carried to our hospital. Computed tomography showed a glass splinter, about 14 cm of length, in the chest cavity. The patient underwent an emergency thoracotomy and it was found that the glass splinter penetrated through the upper lobe to the hilum. After removing the glass, simple closure by suturing the entrance and exit of the upper lobe was performed. The post operational course was uneventful...
November 2016: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/27818817/long-term-retention-of-an-intraorbital-metallic-foreign-body-adjacent-to-the-optic-nerve
#18
Andrew N Siedlecki, Edmund Tsui, Jie Deng, Donald M Miller
We report the case of an asymptomatic 47 year-old male patient who suffered a penetrating wound from a metallic foreign body that became embedded adjacent to the optic nerve for over thirty years, as well as the associated examination, imaging, and fundus photography. Intraorbital metallic foreign bodies can be well tolerated and may not require surgical intervention despite proximity to important structures.
2016: Case Reports in Ophthalmological Medicine
https://www.readbyqxmd.com/read/27818296/low-molecular-weight-chitosan-is-an-effective-antifungal-agent-against-botryosphaeria-sp-and-preservative-agent-for-pear-pyrus-fruits
#19
Yunguang Wang, Bin Li, Xuedan Zhang, Nan Peng, Yuxia Mei, Yunxiang Liang
Antifungal activity and preservative effect of a low molecular weight chitosan (LMWC) sample, derived from chitosan by enzymatic hydrolysis, were investigated in vitro and in vivo. A pathogenic fungal strain was isolated from decayed pear (Pyrus bretschneideri cv. "Huangguan") fruit and identified as Botryosphaeria sp. W-01. LMWC was shown to strongly inhibit W-01 growth based on studies of minimum inhibitory concentration (MIC) and effects on mycelial biomass and radial growth of the fungus. LMWC treatment of W-01 cells reduced ergosterol synthesis and mitochondrial membrane potential (ΔY), early events of apoptosis...
November 3, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27805041/intraepithelial-dendritic-cells-and-sensory-nerves-are-structurally-associated-and-functional-interdependent-in-the-cornea
#20
Nan Gao, Patrick Lee, Fu-Shin Yu
The corneal epithelium consists of stratified epithelial cells, sparsely interspersed with dendritic cells (DCs) and a dense layer of sensory axons. We sought to assess the structural and functional correlation of DCs and sensory nerves. Two morphologically different DCs, dendriform and round-shaped, were detected in the corneal epithelium. The dendriform DCs were located at the sub-basal space where the nerve plexus resides, with DC dendrites crossing several nerve endings. The round-shaped DCs were closely associated with nerve fiber branching points, penetrating the basement membrane and reaching into the stroma...
November 2, 2016: Scientific Reports
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