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https://www.readbyqxmd.com/read/28424127/analysis-of-mortality-in-traumatically-injured-patients-based-on-body-mass-index-and-mechanism-reveals-highest-mortality-among-the-underweight-in-comparison-with-the-ideal-weight-patients
#1
Kevin Treto, Karen Safcsak, David Chesire, Indermeet S Bhullar
The purpose of this study was to evaluate the effect of body mass index (BMI) on mortality after traumatic injury. The records of patients from 2012 to 2015 were retrospectively reviewed. The patients were stratified into the following groups based on admission BMI (kg/m2): underweight (UW) (BMI <19), ideal weight (IW) (BMI = 19-24.9), overweight (OW) (BMI = 25-29.9), obese (OB) (BMI = 30-39.9), and morbid obese (MO) (BMI >40). The groups were well matched with no significant differences in demographics and Injury Severity Score...
April 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28422918/reassessing-the-cardiac-box-a-comprehensive-evaluation-of-the-relationship-between-thoracic-gunshot-wounds-and-cardiac-injury
#2
Rashi Jhunjhunwala, Michael J Mina, Elizabeth I Roger, Christopher J Dente, Michael Heninger, Jacquelyn S Carr, Stacy D Dougherty, Rondi B Gelbard, Jeffrey M Nicholas, Amy D Wyrzykowski, David V Feliciano, Bryan C Morse
BACKGROUND: High energy missiles can cause cardiac injury regardless of entrance site. This study assesses the adequacy of the anatomic borders of the current "cardiac box" to predict cardiac injury. METHODS: Retrospective autopsy review was performed to identify patients with penetrating torso gunshot wounds 2011-2013. Using a circumferential grid system around the thorax, logistic regression analysis was performed to detect differences in rates of cardiac injury from entrance/exit wounds in the "cardiac box" vs...
April 18, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28420038/retrospective-evaluation-of-coyote-attacks-in-dogs-154-cases-1997-2012
#3
Virginia M Frauenthal, Philip Bergman, Robert J Murtaugh
OBJECTIVE: To describe the clinical presentation and outcome of known attacks in client-owned dogs caused by the common coyote, Canis latrans. DESIGN: Retrospective observational study. SETTING: Private referral hospital. ANIMALS: One hundred fifty-four client-owned dogs known to be attacked by coyotes. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Records from a private referral hospital from May 1997 through December 2012 were reviewed...
April 18, 2017: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/28403495/-diagnosis-and-therapeutic-management-in-kidney-ureter-and-bladder-trauma
#4
Karin Hirsch, Marco Heinz, Bernd Wullich
Trauma refers to the destruction of tissues or organs by external forces and it is the most common cause of mortality and morbidity in children (1, 2). Injuries of the genitourinary tract may be the result of blunt (falls, sport injuries, motor vehicle accidents and sexual abuse) or penetrating (stab wounds, gun shots, falling onto sharp objects) injuries. The genitourinary tract is significantly injured in 2.9% of paediatric trauma patients 4.In the paediatric population, the kidney is the most affected organ in the genitourinary tract (>60% of all genitourinary tract injuries) 4...
February 2017: Aktuelle Urologie
https://www.readbyqxmd.com/read/28402472/direct-sternal-administration-of-vancomycin-and-gentamicin-during-closure-prevents-wound-infection%C3%A2
#5
Martin Andreas, Moritz Muckenhuber, Doris Hutschala, Alfred Kocher, Florian Thalhammer, Paul Vogt, Tatjana Fleck, Guenther Laufer
OBJECTIVES: Deep sternal wound infection is still a major complication in patients undergoing cardiac surgery. We previously identified mammary artery harvesting as a risk factor for decreased antibiotic tissue penetration. In addition, other risk factors including diabetes may inhibit sufficient tissue penetration of perioperative antibiotic prophylaxis. A novel closure protocol applying 2 topical antibiotics and further recommendations for sternal wiring was introduced at our department to decrease the incidence of sternal wound infections...
April 10, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28401673/morphology-of-modern-arrowhead-tips-on-human-skin-analog
#6
LokMan Sung, Kilak Kesha, Jeffrey Hudson, Kelly Root, Leigh Hlavaty
Archery has experienced a recent resurgence in participation and has seen increases in archery range attendance and in children and young adults seeking archery lessons. Popular literature and movies prominently feature protagonists well versed in this form of weaponry. Periodic homicide cases in the United States involving bows are reported, and despite this and the current interest in the field, there are no manuscripts published on a large series of arrow wounds. This experiment utilizes a broad selection of modern arrowheads to create wounds for comparison...
April 12, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28400668/nontuberculous-mycobacterial-infection-of-the-musculoskeletal-system-in-immunocompetent-hosts
#7
Manit K Gundavda, Hitendra G Patil, Vikas M Agashe, Rajeev Soman, Camilla Rodriques, Ramesh B Deshpande
BACKGROUND: Nontuberculous mycobacteria (NTM) were considered saprophytic organisms for many years but now are recognized as human pathogens. Although humans are routinely exposed to NTM, the rate of clinical infection is low. Such infections usually occur in the elderly and in patients who are immunocompromised. However, there has been an increasing incidence in recent years of infections in immunocompetent hosts. NTM infections in immunocompetent individuals are secondary to direct inoculation either contamination from surgical procedures or penetrating injuries rather than hematogenous dissemination...
March 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/28397809/second-harmonic-generation-imaging-of-corneal-stroma-after-infection-by-pseudomonas-aeruginosa
#8
Danielle M Robertson, Nathan A Rogers, W Matthew Petroll, Meifang Zhu
Pseudomonas aeruginosa is a pathogenic gram-negative organism that has the ability to cause blinding corneal infections following trauma and during contact lens wear. In this study, we investigated the directional movement and orientation of an invasive corneal isolate of P. aeruginosa in the corneal stroma during infection of ex vivo and in vivo rabbit corneas using multiphoton fluorescence and second harmonic generation (SHG) imaging. Ex vivo, rabbit corneas were subject to three partial thickness wounds prior to inoculation...
April 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28391495/boric-acid-inhibition-of-trichophyton-rubrum-growth-and-conidia-formation
#9
Martin Schmidt
Trichophyton rubrum is a common human dermatophyte that is the causative agent of 80-93% of fungal infections of the skin and nails. While dermatophyte infections in healthy people are easily treatable with over-the-counter medications, such infections pose a higher risk for patients with compromised immune function and impaired regenerative potential. The efficacy of boric acid (BA) for the treatment of vaginal yeast infections prompted an investigation of the effect of BA on growth and morphology of T. rubrum...
April 8, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28390919/symptomatic-deep-femoral-artery-pseudoaneurysm-endovascular-exclusion-case-report-and-literature-review
#10
Felice Pecoraro, Ettore Dinoto, Umberto M Bracale, Giovanni Badalamenti, Arduino Farina, Guido Bajardi
Deep femoral artery pseusoaneurysms (DFAPs) are rare and generally occur after penetrating trauma or surgical procedures. A 36-year old obese man presented with pain in correspondence of the anterior-lateral thigh after 6 months from gunshot wound. Duplex and computed tomography (CT) showed a bilobed right DFAP (maximal diameter 12.9 cm). The patient was managed urgently, under local anaesthesia, by placement in the distal DFA of a Viabahn 8 x 100mm stent-graft (W L Gore & Associates, Inc). The post-operative course was uneventful and the 24-months CT showed regular stent-graft patency and 20 mm DFPA shrinkage...
April 5, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28369494/emergency-video-assisted-thoracoscopic-surgery-for-haemopneumothorax-and-diaphragm-repair-after-stabbing-performed-through-pre-existing-wounds
#11
Aman Coonar, Laurence Orchard
Video of video-assisted thoracoscopic surgery (VATS) on a 16-year old who had been stabbed. The knife penetrated the diaphragm, lung and intercostal pedicle causing a haemopneumothorax. A chest drain was inserted by the trauma team. VATS was performed entirely through the stab and chest drain pre-existing wounds without extension.
March 27, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28369306/surgical-management-of-penetrating-thoracic-injuries-during-the-paris-attacks-on-13-november-2015
#12
Guillaume Boddaert, Pierre Mordant, Françoise Le Pimpec-Barthes, Emmanuel Martinod, Sonia Aguir, Pascal Leprince, Mathieu Raux, Jean-Paul Couëtil, Antonio Fiore, Thomas Lescot, Brice Malgras, François Pons, Yves Castier
OBJECTIVES: The Paris terrorist attacks on 13 November 2015 caused 482 casualties, including 130 deaths and 352 wounded. Facing these multisite terrorist attacks, Parisian public and military hospitals simultaneously managed numerous patients with penetrating thoracic injuries. The aim of this study was to analyse this cohort, the injury patterns, and assess the results of this mobilization. METHODS: The clinical records of all patients admitted to Parisian public and military hospitals with a penetrating thoracic injury related to the Paris 13 November terrorist attacks were reviewed...
March 27, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28362873/chitosan-propolis-nanoparticle-formulation-demonstrates-anti-bacterial-activity-against-enterococcus-faecalis-biofilms
#13
Teik Hwa Ong, Ebenezer Chitra, Srinivasan Ramamurthy, Rajinikanth Paruvathanahalli Siddalingam, Kah Hay Yuen, Stephen Periathamby Ambu, Fabian Davamani
Propolis obtained from bee hives is a natural substance with antimicrobial properties. It is limited by its insolubility in aqueous solutions; hence ethanol and ethyl acetate extracts of Malaysian propolis were prepared. Both the extracts displayed antimicrobial and anti-biofilm properties against Enterococcus faecalis, a common bacterium associated with hospital-acquired infections. High performance liquid chromatography (HPLC) analysis of propolis revealed the presence of flavonoids like kaempferol and pinocembrin...
2017: PloS One
https://www.readbyqxmd.com/read/28358901/custom-rt-qpcr-array-for-glaucoma-filtering-surgery-prognosis
#14
Iñaki Rodriguez-Agirretxe, Iker Garcia, Javier Soria, Tatiana Maria Suarez, Arantxa Acera
Excessive subconjunctival scarring is the main reason of failure of glaucoma filtration surgery. We analyzed conjunctival and systemic gene expression patterns after non penetrating deep sclerectomy (NPDS). To find expression patterns related to surgical failure and their correlation with the clinical outcomes. This study consisted of two consecutive stages. The first was a prospective analysis of wound-healing gene expression profile of six patients after NPDS. Conjunctival samples and peripheral blood samples were collected before and 15, 90,180, and 360 days after surgery...
2017: PloS One
https://www.readbyqxmd.com/read/28344815/occupational-exposure-to-sharps-injury-among-healthcare-providers-in-ethiopia-regional-hospitals
#15
Nigussie Tadesse Sharew, Getaneh Baye Mulu, Tesfa Dejenie Habtewold, Kefyalew Dagne Gizachew
BACKGROUND: Sharps injury is a penetrating stab wound from a needle, scalpel, or another sharp object that may result in exposure to blood or other body fluids. According to World Health Organization pooled estimate, the annual incidence of sharps injury in Africa was ranged from 2.10 to 4.68 per person per year, but research data in Ethiopia is limited. The aim of the study was to investigate sharps injury prevalence and associated risk factors. METHODS: Institution based cross-sectional study was conducted with 200 healthcare providers (HCP) in Northeast Ethiopia...
2017: Annals of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28336300/development-of-topical-delivery-systems-for-flightless-neutralizing-antibody
#16
Hanif Haidari, Qian Zhang, Elizabeth Melville, Zlatko Kopecki, Yunmei Song, Allison J Cowin, Sanjay Garg
Flightless I (Flii) is an actin remodelling protein important for cytoskeletal regulation and cellular processes including migration, proliferation and adhesion. Previous studies have clearly identified Flii as a novel therapeutical target for improved wound repair and have demonstrated Flii regulation using Flii neutralizing antibodies (FnAb) in different models of wound healing in vivo. Here we describe the development of an optimised topical delivery system that can neutralize Flii activity in the epidermis...
March 20, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28326930/effects-of-jwh015-in-cytokine-secretion-in-primary-human-keratinocytes-and-fibroblasts-and-its-suitability-for-topical-transdermal-delivery
#17
Alicia Bort, Perla A Alvarado-Vazquez, Carolina Moracho-Vilrriales, Kristopher G Virga, Giuseppe Gumina, Alfonso Romero-Sandoval, Scott Asbill
Background JWH015 is a cannabinoid (CB) receptor type 2 agonist that produces immunomodulatory effects. Since skin cells play a key role in inflammatory conditions and tissue repair, we investigated the ability of JWH015 to promote an anti-inflammatory and pro-wound healing phenotype in human primary skin cells. Methods Human primary keratinocytes and fibroblasts were stimulated with lipopolysaccharide. The mRNA expression of cannabinoid receptors was determined using RT-PCR. The effects of JWH015 (0.05, 0...
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28326453/violent-trauma-recidivism-does-all-violence-escalate
#18
R M Nygaard, A P Marek, S R Daly, J M Van Camp
PURPOSE: Rates of trauma patients presenting with history of prior trauma range from 25 to 44%. Outcomes involving recidivists in the setting of intentional trauma, especially penetrating trauma, are conflicting. We hypothesized that if violence does escalate with successive incidence, then injuries due to successive violence should escalate or become increasingly severe with successive admissions. METHODS: The trauma registry from an urban level I adult and pediatric trauma center was queried for injuries due to blunt assault, stabbing, and firearm injury...
March 22, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/28318811/st-elevation-myocardial-infarction-after-penetrating-thoracic-trauma
#19
Kiran Faryar, Michael P Flaherty, Martin Huecker
BACKGROUND: ST-segment elevation myocardial infarction (STEMI) may complicate penetrating thoracic trauma. CASE REPORT: This report describes a 42-year-old man who sustained a self-inflicted gunshot wound to the left chest. Electrocardiogram showed ST elevation in the inferior leads. Emergent catheterization was not recommended and conservative management was initiated. Cardiac catheterization 4 days later showed no perturbation of the coronary arteries, neither atherosclerotic nor traumatic...
March 17, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28315385/a-study-on-the-in-vitro-percutaneous-absorption-of-silver-nanoparticles-in-combination-with-aluminum-chloride-methyl-paraben-or-di-n-butyl-phthalate
#20
Katarzyna Domeradzka-Gajda, Marek Nocuń, Joanna Roszak, Beata Janasik, C Derrick Quarles, Wojciech Wąsowicz, Jarosław Grobelny, Emilia Tomaszewska, Grzegorz Celichowski, Katarzyna Ranoszek-Soliwoda, Małgorzata Cieślak, Dorota Puchowicz, Jhanis J Gonzalez, Richard E Russo, Maciej Stępnik
Some reports indicate that the silver released from dermally applied products containing silver nanoparticles (AgNP) (e.g. wound dressings or cosmetics) can penetrate the skin, particularly if damaged. AgNP were also shown to have cytotoxic and genotoxic activity. In the present study percutaneous absorption of AgNP of two different nominal sizes (Ag15nm or Ag45nm by STEM) and surface modification, i.e. citrate or PEG stabilized nanoparticles, in combination with cosmetic ingredients, i.e. aluminum chloride (AlCl3), methyl paraben (MPB), or di-n-butyl phthalate (DBPH) was assessed using in vitro model based on dermatomed pig skin...
March 14, 2017: Toxicology Letters
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