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https://www.readbyqxmd.com/read/29022789/the-impact-of-mechanism-on-the-management-and-outcome-of-penetrating-colonic-trauma
#1
G V Oosthuizen, V Y Kong, T Estherhuizen, J L Bruce, G L Laing, J J Odendaal, D L Clarke
Introduction In light of continuing controversy surrounding the management of penetrating colonic injuries, we set out to compare the outcome of penetrating colonic trauma according to whether the mechanism of injury was a stab wound or a gunshot wound. Methods Our trauma registry was interrogated for the 5-year period from January 2012 to December 2016. All patients over the age of 18 years with penetrating trauma (stab or gunshot) and with intraoperatively proven colonic injury were reviewed. Details of the colonic and concurrent abdominal injuries were recorded, together with the operative management strategy...
September 15, 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/28993784/the-intergenic-interplay-between-aldose-1-epimerase-like-protein-and-pectin-methylesterase-in-abiotic-and-biotic-stress-control
#2
Ekaterina V Sheshukova, Tatiana V Komarova, Denis V Pozdyshev, Natalia M Ershova, Anastasia V Shindyapina, Vadim N Tashlitsky, Eugene V Sheval, Yuri L Dorokhov
The mechanical damage that often precedes the penetration of a leaf by a pathogen promotes the activation of pectin methylesterase (PME); the activation of PME leads to the emission of methanol, resulting in a "priming" effect on intact leaves, which is accompanied by an increased sensitivity to Tobacco mosaic virus (TMV) and resistance to bacteria. In this study, we revealed that mRNA levels of the methanol-inducible gene encoding Nicotiana benthamiana aldose 1-epimerase-like protein (NbAELP) in the leaves of intact plants are very low compared with roots...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28988939/susceptibility-of-wounded-and-intact-black-soldier-fly-hermetia-illucens-l-diptera-stratiomyidae-to-entomopathogenic-nematodes
#3
Joseph Tourtois, Jared Gregory Ali, Matthew Grieshop
Production costs and limited regional availability are two key factors limiting the widespread adoption of entomopathogenic nematodes (Rhabditida: Heterorhabditidae and Steinernematidae) in biological control programs. We explore the potential of using black soldier fly larvae Hermetia illucens (L.) (Diptera: Stratiomyidae) as an alternative in vivo rearing host to the greater wax moth, Galleria mellonella (L.) (Lepidoptera: Pyralidae). We injured black soldier fly larvae to test the hypothesis that the tough cuticle was preventing the penetration of founding infective juveniles (IJs) into the host and egress of offspring from the cadaver...
October 6, 2017: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/28975707/skin-penetration-and-uv-damage-prevention-by-nanoberries
#4
Paula Bucci, María Jimena Prieto, Laura Milla, María Natalia Calienni, Luis Martinez, Viviana Rivarola, Silvia Alonso, Jorge Montanari
BACKGROUND: Ethanolic extract from blueberry (Vaccinium myrtillus) is rich in anthocyanins and thus exhibits antioxidant activity. On the other hand, ultradeformable liposomes are capable of penetrating to the impermeable barrier of skin. Nanoberries are ultradeformable liposomes carrying blueberry extract. OBJECTIVES: In this study, their capacity to penetrate the stratum corneum and photodamage prevention were tested, with the aim of developing a topical formulation for skin protection from environmental damage...
October 3, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28975247/association-of-prehospital-mode-of-transport-with-mortality-in-penetrating-trauma-a-trauma-system-level-assessment-of-private-vehicle-transportation-vs-ground-emergency-medical-services
#5
Michael W Wandling, Avery B Nathens, Michael B Shapiro, Elliott R Haut
Importance: Time to definitive care following injury is important to the outcomes of trauma patients. Prehospital trauma care is provided based on policies developed by individual trauma systems and is an important component of the care of injured patients. Given a paucity of systems-level trauma research, considerable variability exists in prehospital care policies across trauma systems, potentially affecting patient outcomes. Objective: To evaluate whether private vehicle prehospital transport confers a survival advantage vs ground emergency medical services (EMS) transport following penetrating injuries in urban trauma systems...
September 20, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28962915/a-d-a-m-test-antibiofilm-dressing-s-activity-measurement-simple-method-for-evaluating-anti-biofilm-activity-of-drug-saturated-dressings-against-wound-pathogens
#6
Adam F Junka, Anna Żywicka, Patrycja Szymczyk, Mariusz Dziadas, Marzena Bartoszewicz, Karol Fijałkowski
In the present article, we propose a simple Antibiofilm Dressing's Activity Measurement (A.D.A.M.) test that allows to check in vitro a dressing's suitability against biofilm-related wound infections. To perform the test, three agar discs are covered with biofilm formed by the tested pathogen after which they are assembled one over another in the form of an agar plug and placed in the well of a 24-well plate. The top disc is covered with the analyzed dressing and the entire set is incubated for 24h. During this time, the investigated antimicrobial substance is released from the dressing and penetrates to subsequent biofilm-covered agar discs...
September 28, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/28960501/palovarotene-inhibits-connective-tissue-progenitor-cell-proliferation-in-a-rat-model-of-combat-related-heterotopic-ossification
#7
Benjamin M Wheatley, Katherine E Cilwa, Devaveena Dey, Ammar T Qureshi, Jonathan G Seavey, Allison M Tomasino, Erin M Sanders, Wesley Bova, Cynthia A Boehm, Masahiro Iwamoto, Benjamin K Potter, Jonathan A Forsberg, George F Muschler, Thomas A Davis
Heterotopic ossification (HO) develops in the extremities of wounded service members and is common in the setting of high-energy penetrating injuries and blast-related amputations. No safe and effective prophylaxis modality has been identified for this patient population. Palovarotene has been shown to reduce bone formation in traumatic and genetic models of HO. The purpose of this study was to determine the effects of Palovarotene on inflammation, progenitor cell proliferation and gene expression following a blast-related amputation in a rodent model (n = 72 animals), as well as the ability of Raman spectroscopy to detect early HO before radiographic changes are present...
September 28, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28958271/operative-outcomes-after-open-abdominal-wall-reconstruction-with-retromuscular-mesh-fixation-using-fibrin-glue-versus-transfascial-sutures
#8
COMPARATIVE STUDY
Adam S Weltz, Udai S Sibia, H Reza Zahiri, Alexa Schoeneborn, Adrian Park, Igor Belyansky
Ideal fixation techniques have not been fully elucidated at the time of complex open abdominal wall reconstruction (AWR). We compared operative outcomes and quality of life with retromuscular mesh fixation using fibrin glue (FG) versus transfascial sutures (TS). Retrospective review identified complex hernia patients who underwent open AWR with mesh from November 2012 through April 2016. Multivariate analysis examined postoperative outcomes between groups. Quality of life was assessed using the Carolinas Comfort Scale...
September 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28956593/flexible-nanoholey-patches-for-antibiotic-free-treatments-of-skin-infections
#9
Chengnan Li, Ran Ye, Julie Bouckaert, Amaia Zurutuza, Djamel Drider, Tetiana Dumych, Solomiya Paryzhak, Volodymyr Vovk, Rostyslav O Bilyy, Sorin Melinte, Musen Li, Rabah Boukherroub, Sabine Szunerits
Despite the availability of different antibiotics, bacterial infections are still one of the leading causes of hospitalization and mortality. The clinical failure of antibiotic treatment is due to a general poor antibiotic penetration to bacterial infection sites as well as the development of antibiotic-resistant pathogens. In the case of skin infection, the wound is covered by exudate, making it impermeable to topical antibiotics. The development of a flexible patch allowing a rapid and highly efficient treatment of subcutaneous wound infections via photothermal irradiation is presented here...
October 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28955754/suppression-of-mage-a10-alters-the-metastatic-phenotype-of-tongue-squamous-cell-carcinoma-cells
#10
Bruna Dos Santos Mendonça, Michelle Agostini, Iara Gonçalves Aquino, Wagner Barbosa Dias, Débora Campanella Bastos, Franklin D Rumjanek
MAGE-A10 is a member of the MAGE protein family (melanoma associated antigen) which is overexpressed in cancer cells. Although MAGE-A10 has been characterized for some time and is generally associated to metastasis its function remains unknown. Here we describe experiments using as models oral squamous cell carcinoma (OSCC) cell lines displaying increasing metastatic potential (LN1 and LN2). These cell lines were transduced with lentivirus particles coding for short hairpin against MAGE-A10 mRNA. Repression of MAGE-A10 expression in LN2 cells altered their morphology and impaired growth of LN1 and LN2 cell lines...
July 2017: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/28950788/computed-tomography-angiography-is-the-definitive-vascular-imaging-modality-for-penetrating-neck-injury-a-south-african-experience
#11
A S Madsen, V Y Kong, G V Oosthuizen, J L Bruce, G L Laing, D L Clarke
BACKGROUND AND AIMS: Computed tomography angiography has become central to the diagnostic algorithm for penetrating neck injury, but despite its widespread use the literature to support this adoption is limited. We reviewed our experience with computed tomography angiography for the identification of vascular trauma in hemodynamically stable patients with penetrating neck injury at a major trauma center in South Africa. MATERIALS AND METHODS: A prospectively kept trauma registry capturing data in real time was retrospectively reviewed...
September 1, 2017: Scandinavian Journal of Surgery: SJS
https://www.readbyqxmd.com/read/28950196/a-therapeutic-polyelectrolyte-vitamin-c-nanoparticulate-system-in-polyvinyl-alcohol-alginate-hydrogel-an-approach-to-treat-skin-and-soft-tissue-infections-caused-by-staphylococcus-aureus
#12
Liya George, M C Bavya, K Vimal Rohan, R Srivastava
Staphylococcus aureus infections affecting the skin and soft tissues are of significant health concern and an unmet need to be addressed. The lack of drug penetration into the infectious site is the main clinical challenge. Once the pathogen invades the wounded skin, it attenuates biological response pathways, leading to chronic infection. Wound infections are associated with alkaline pH due to the presence of bacteria, whereas creation of an acidic environment around the wound bed promotes faster healing. Herein, we develop injectable drug loaded nanoparticulate system of vancomycin encapsulated polycaprolactone nanoparticles coated with polyelectrolyte-Vitamin C in polyvinyl alcohol-alginate gel (D-PCL-PVc-PVA(Alg)...
September 14, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28948121/novel-use-of-an-image-guided-stereotactic-approach-in-trauma-for-localization-of-transcranial-bullet
#13
Dat T Vo, George F Cravens, Robert E Germann
Penetrating brain injuries from gunshot wounds can carry a poor prognosis and require an aggressive, multifaceted approach to obtain a good prognosis and outcome. An initial evaluation requires appropriate imaging studies followed by management and prophylaxis against increased intracranial pressure, infection, and seizures. Surgical management is then followed to ensure the watertight closure of any wounds, removal of any areas of hematoma, and removal of any potential areas of infection. In this paper, we report the case of a patient who presented with a self-inflicted gunshot wound to the head and then received aggressive medical and surgical management...
July 21, 2017: Curēus
https://www.readbyqxmd.com/read/28941568/resuscitation-thoracotomy
#14
G Boddaert, E Hornez, H De Lesquen, A Avramenko, B Grand, T MacBride, J-P Avaro
Resuscitation thoracotomy is a rarely performed procedure whose use, in France, remains marginal. It has five specific goals that correspond point-by-point to the causes of traumatic cardiac arrest: decompression of pericardial tamponade, control of cardiac hemorrhage, performance of internal cardiac massage, cross-clamping of the descending thoracic aorta, and control of lung injuries and other intra-thoracic hemorrhage. This approach is part of an overall Damage Control strategy, with a targeted operating time of less than 60minutes...
September 20, 2017: Journal of Visceral Surgery
https://www.readbyqxmd.com/read/28932339/penetrating-keratoplasty-for-keratoconus-excimer-versus-femtosecond-laser-trephination
#15
Berthold Seitz, Achim Langenbucher, Tobias Hager, Edgar Janunts, Moatasem El-Husseiny, Nora Szentmáry
BACKGROUND: In case of keratoconus, rigid gas-permeable contact lenses as the correction method of first choice allow for a good visual acuity for quite some time. In a severe stage of the disease with major cone-shaped protrusion of the cornea, even specially designed keratoconus contact lenses are no more tolerated. In case of existing contraindications for intrastromal ring segments, corneal transplantation typically has a very good prognosis. METHODS: In case of advanced keratoconus - especially after corneal hydrops due to rupture of Descemet's membrane - penetrating keratoplasty (PKP) still is the surgical method of first choice...
2017: Open Ophthalmology Journal
https://www.readbyqxmd.com/read/28930951/routine-computed-tomography-after-recent-operative-exploration-for-penetrating-trauma-what-injuries-do-we-miss
#16
April E Mendoza, Christopher A Wybourn, Anthony G Charles, Andre R Campbell, Bruce A Cairns, Margaret M Knudson
BACKGROUND: Patients with penetrating trauma who cannot be stabilized undergo operative intervention without preoperative imaging. In such cases, postoperative imaging may reveal additional injuries not identified during the initial operative exploration. The purpose of this study is to explore the utility of postoperative CT imaging in the setting of penetrating trauma. METHODS: This was a retrospective analysis of patients with penetrating trauma treated at an urban Level 1 trauma center between 2010 and 2015...
October 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28928592/the-journey-of-harmless-bullet-the-perioperative-care-of-penetrating-cardiac-injury
#17
Ahmad Abou-Leila, Gennadiy Voronov
Traumatic injuries to the heart contribute significantly to trauma are associated with high mortality. Cardiac gunshot wounds (GSW) are considered more lethal compared to other injuries and present several unique challenges to the anesthesia management and perioperative care. We are reporting a rare case of a trauma victim who survived a GSW to the heart. We will discuss the perioperative care of penetrating cardiac injuries, the role of the anesthesia team in resuscitation, safe anesthesia induction, cardiopulmonary bypass management, and the essential role of intraoperative transesophageal echocardiogram imaging...
July 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/28926886/-keratectomy-combined-with-intrastromal-injection-of-voriconazole-in-treating-fungal-keratitis
#18
S X Li, J Biang, X Li, L T Zhang, W Y Shi
Objective: To investigate the treatment effect of keratectomy combined with intrastromal injection of voriconazole on fungal keratitis. Methods: Retrospective study. Ninety-eight fungal keratitis patients (98 eyes) were treated by keratectomy combined with intrastromal injection of voriconazole in Shandong Eye Hospital from January 2013 to May 2015. The corneal ulcers were mostly located in the paracentral or peripheral cornea, which incompletely blocked the pupil area. Slit lamp and anterior segment optical coherence tomography (AS-OCT) were used for lesion detection...
September 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28916875/traumatic-injuries-to-the-pregnant-patient-a-critical-literature-review
#19
REVIEW
P Petrone, P Jiménez-Morillas, A Axelrad, C P Marini
INTRODUCTION: Trauma during pregnancy is the leading non-obstetrical cause of maternal death and a significant public health burden. This study reviews the most common causes of trauma during pregnancy, morbidity, and mortality, and the impact upon perinatal outcomes associated with trauma, providing a management approach to pregnant trauma patients. MATERIALS AND METHODS: A systematic review of the current literature from January 2006 to July 2016 was performed...
September 15, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/28912997/laparoscopic-repair-of-diaphragmatic-rupture-a-case-report-with-radiological-and-surgical-correlation
#20
Patrick Nguyen, Bonnie Davis, Daniel D Tran
The leading cause of diaphragmatic rupture is penetrating abdominal trauma, including gunshot- and stab-related wounds; however, diaphragmatic rupture can also result from blunt trauma to the abdomen. The diagnosis can be difficult to make as the physical examination may be unremarkable, and imaging, that is, a conventional chest X-ray and/or CT imaging, may initially fail to reveal the injury. Failure to recognize diaphragmatic rupture can result in a delayed presentation, sometimes years later, with a potential catastrophic outcome...
2017: Case Reports in Surgery
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