keyword
MENU ▼
Read by QxMD icon Read
search

Ganoderma

keyword
https://www.readbyqxmd.com/read/28933106/-review-for-sedative-and-hypnotic-mechanism-of-sedative-traditional-chinese-medicine-and-relative-active-components-on-neurotransmitters
#1
REVIEW
Fei-Yan Zhang, Jing-Jing Li, Ying Zhou, Xiao-Yu Xu
The sedative traditional Chinese medicine has a long history of clinical experience in treating insomnia. The main pharmacological effects of sedative agents are sedation, hypnosis, antianxiety and antidepression which might be related to certain neurotransmitters and cytokines and so on. This review summarized the mechanism of sedative traditional Chinese medicine and its active monomers based on neurotransmitters, including GABA, Glu, 5-HT, DA, NE and their metabolites 5-HIAA, HVA, DOPAC. The results showed that the most research about the sedative medicine at present was throught serotonergic and GABA ergic system...
December 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28931319/lanostane-triterpenoids-from-cultivated-fruiting-bodies-of-the-basidiomycete-ganoderma-australe
#2
Masahiko Isaka, Panida Chinthanom, Sermsiri Mayteeworakoon, Kobkul Laoteng, Wilunda Choowong, Rattaket Choeyklin
A new lanostane triterpene (1), together with three known compounds (2-4), were isolated from cultivated fruiting bodies of the basidiomycete Ganoderma australe. The structure was elucidated on the basis of NMR spectroscopic and mass spectrometry data. The olefinic geometry of methyl australate (2) was revised from 20(22)Z to 20(22)E. These compounds (1-4) were different from the lanostanes isolated from mycelial cultures of the same strain source.
September 20, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28915465/traditional-chinese-medicinal-herbs-as-potential-ache-inhibitors-for-anti-alzheimer-s-disease-a-review
#3
REVIEW
Yingying Jiang, Hongwei Gao, Gulmira Turdu
Alzheimer's disease (AD) is a progressive neurodegenerative disease affecting 25 million people worldwide, and cholinergic hypothesis is considered as an important hypotheses in the processes of improving cognitive function and recognition skills in recent years. For the long-term treatment of AD, traditional Chinese medicine are particularly suitable for drug discovery. In this review, we sum up six traditional Chinese medicinal herbs concerned with development of AChEIs, including Herba Epimedii, Coptis Chinensis Franch, Rhizoma Curcumae Longae, Green tea, Ganoderma, Panax Ginseng...
September 6, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/28912878/triterpenoids-from-ganoderma-lucidum-inhibit-the-activation-of-ebv-antigens-as-telomerase-inhibitors
#4
Dong-Shu Zheng, Liang-Shu Chen
Nasopharyngeal carcinoma (NPC) is a malignant disease that threatens the health of humans. To find effective agents for the inhibition of Epstein-Barr virus (EBV) infection, which is associated with NPC, a phytochemical investigation of Ganoderma lucidum was carried out in the present study. Five triterpenoids were identified, including ganoderic acid A (compound 1), ganoderic acid B (compound 2), ganoderol B (compound 3), ganodermanontriol (compound 4), and ganodermanondiol (compound 5), on the basis of spectroscopic analysis...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28901910/alternative-oxidase-impacts-ganoderic-acid-biosynthesis-by-regulating-intracellular-ros-levels-in-ganoderma-lucidum
#5
Deng-Ke Shi, Jing Zhu, Ze-Hua Sun, Guang Zhang, Rui Liu, Tian-Jun Zhang, Sheng-Li Wang, Ang Ren, Ming-Wen Zhao
The alternative oxidase (AOX), which forms a branch of the mitochondrial respiratory electron transport pathway, functions to sustain electron flux and alleviate reactive oxygen species (ROS) production. In this article, a homologous AOX gene was identified in Ganoderma lucidum. The coding sequence of the AOX gene in G. lucidum contains 1038 nucleotides and encodes a protein of 39.48 kDa. RNA interference (RNAi) was used to study the function of AOX in G. lucidum, and two silenced strains (AOXi6 and AOXi21) were obtained, showing significant decreases of approximately 60 and 50 %, respectively, in alternative pathway respiratory efficiency compared to WT...
September 13, 2017: Microbiology
https://www.readbyqxmd.com/read/28893685/protective-effects-of-a-g-lucidum-proteoglycan-on-ins-1-cells-against-iapp-induced-apoptosis-via-attenuating-endoplasmic-reticulum-stress-and-modulating-chop-jnk-pathways
#6
Yan-Ming He, Qiang Zhang, Min Zheng, Zhao-Hua Fan, Yun-Hao Li, Dan Zhang, Zeng Zhang, Sha-Sha Yuan, Yan-Yan Wang, Ping Zhou, Hong-Jie Yang
Fudan-Yueyang-G. lucidum (FYGL) is a water-soluble macromolecular proteoglycan extracted from Ganoderma lucidum which has been used for health promotion for a long time in China. The aim of this study was to investigate the protective effects of FYGL on INS-1 rat insulinoma beta cells against IAPP-induced cell apoptosis, as well as the underlying mechanisms. The results showed that apoptotic cells were significantly increased when incubated with islet amyloid polypeptide (IAPP). However, cytotoxicity of IAPP was significantly attenuated by co-incubation of the cells with FYGL...
September 8, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28892293/phospholipase-d-and-phosphatidic-acid-mediate-heat-stress-induced-secondary-metabolism-in-ganoderma-lucidum
#7
Yong-Nan Liu, Xiao-Xiao Lu, Chen Dai, Ya-Ping Lu, Ang Ren, Liang Shi, Jing Zhu, Ai-Liang Jiang, Han-Shou Yu, Ming-Wen Zhao
Phospholipid-mediated signal transduction plays a key role in responses to environmental changes, but little is known about the role of phospholipid signalling in microorganisms. Heat stress (HS) is one of the most important environmental factors. Our previous study found that HS could induce the biosynthesis of the secondary metabolites, ganoderic acids (GA). Here, we performed a comprehensive mass spectrometry-based analysis to investigate HS-induced lipid remodelling in Ganoderma lucidum. In particular, we observed a significant accumulation of phosphatidic acid (PA) upon HS...
September 11, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28890375/anti-inflammatory-properties-of-glpss58-a-sulfated-polysaccharide-from-ganoderma-lucidum
#8
Kai Zhang, Yanfang Liu, Xiangli Zhao, Qingjiu Tang, Jens Dernedde, Jingsong Zhang, Hua Fan
Sulfated polysaccharides exhibit various biological properties, including anti-coagulant, anti-oxidant, anti-viral, anti-cancer, anti-inflammatory and immune regulatory activities. In the present study, the anti-inflammatory properties of GLPss58, a sulfated polysaccharide from Ganoderma lucidum formed by chemical sulfation, were investigated. We found that GLPss58 inhibited L-selectin/sTyr-sLeX binding significantly, blocked the binding of anti-L-selectin antibodies to L-selectin on the surface of human peripheral blood lymphocytes, and inhibited the secondary lymphoid tissue chemokine-induced chemotactic invasion of HPBLs...
September 7, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28882624/network-pharmacology-analysis-of-the-anti-cancer-pharmacological-mechanisms-of-ganoderma-lucidum-extract-with-experimental-support-using-hepa1-6-bearing-c57-bl-6-mice
#9
Ruo-Lin Zhao, Yu-Min He
ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum (GL) is an oriental medical fungus, which was used to prevent and treat many diseases. Previously, the effective components of Ganoderma lucidum extract (GLE) were extracted from two kinds of GL, Ganoderma lucidum (Leyss. Ex Fr.) Karst. and Ganoderma sinense Zhao, Xu et Zhang, which have been used for adjuvant anti-cancer clinical therapy for more than 20 years. However, its concrete active components and its regulation mechanisms on tumor are unclear...
September 4, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28877835/pathological-changes-in-app-ps-1-transgenic-mouse-models-of-alzheimer-s-disease-treated-with-ganoderma-lucidum-preparation
#10
Chuan Qin, Shan-Qiu Wu, Bao-Sheng Chen, Xiao-Xian Wu, Kun-Yao Qu, Jun-Min Liu, Gui-Fang Zhang, Yan-Feng Xu, Shunli Shu, Lihua Sun, Yan-Yong Li, Hua Zhu, Lan Huang, Chun-Mei Ma, Yu-Huan Xu, Yun-Lin Han, Yao-Zeng Lu
Objective To explore the efficacy of ganoderma lucidum preparation(Ling Zhi) in treating APP/PS-1 transgenic mouse models of Alzheimer's disease(AD).Methods APP/PS-1 transgenic mice of 4 months were randomly divided into model group,ganoderma lucidum treatment groups,including high [2250 mg/(kg·d)] and middle [750 mg/(kg·d)] dose groups,i.e.LZ-H and LZ-M groups,and the positive control group(treated with donepezil hydrochloride [2 mg/(kg·d)]).In addition,C57BL/6J wild mice were selected as normal group.The animals were administered for 4 months...
August 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/28866857/malachite-green-and-crystal-violet-decolorization-by-ganoderma-lucidum-and-pleurotus-ostreatus-supernatant-and-by-rgllcc1-and-rpoxa-1b-concentrates-molecular-docking-analysis
#11
Edwin D Morales-Álvarez, Claudia M Rivera-Hoyos, Sergio A Poveda-Cuevas, Edwin A Reyes-Guzmán, Aura M Pedroza-Rodríguez, Edgar A Reyes-Montaño, Raúl A Poutou-Piñales
Laccases catalyze the oxidation of various aromatic organic compounds concomitantly with molecular oxygen reduction to water. Triphenylmethane dyes are synthetic compounds widely used in diverse industries. Their removal from effluents is difficult, due to their high degree of structural complexity; hence, their high concentration in effluents cause a negative impact on the environment. In the present work, molecular docking was used to evaluate interactions between rGlLCC1 or rPOXA 1B enzymes with Crystal Violet (CV) or Malachite Green (MG) dyes...
September 2, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28866417/effects-of-ganoderma-lucidum-polysaccharides-against-doxorubicin-induced-cardiotoxicity
#12
Fan Xu, Xiao Li, Xu Xiao, Lan-Fang Liu, Li Zhang, Ping-Ping Lin, Sheng-Lin Zhang, Qing-Shan Li
Doxorubicin (DOX) is a widely used anthracycline derivative anticancer drug, but the use of DOX in clinical applications is limited by its cardiotoxicity. In the current research, we were aiming to assess the effects of Ganoderma lucidum polysaccharides (GLPS) on DOX-induced cardiotoxicity and to illustrate the associated mechanisms. H9c2 rat cardiomyocytes were treated with DOX in the absence or presence of GLPS, and we found GLPS treatment ameliorated DOX-induced H9c2 cell death. Moreover, results of in vivo studies indicated that GLPS significantly decreased the serum levels of lactate dehydrogenase (LDH), creatine kinase (CK) and aspartate aminotransferase (AST) and attenuated DOX-induced histological changes of the heart tissues...
August 31, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28861093/the-phenylpropanoid-pathway-and-lignin-in-defense-against-ganoderma-boninense-colonized-root-tissues-in-oil-palm-elaeis-guineensis-jacq
#13
Nisha T Govender, Maziah Mahmood, Idris A Seman, Mui-Yun Wong
Basal stem rot, caused by the basidiomycete fungus, Ganoderma boninense, is an economically devastating disease in Malaysia. Our study investigated the changes in lignin content and composition along with activity and expression of the phenylpropanoid pathway enzymes and genes in oil palm root tissues during G. boninense infection. We sampled control (non-inoculated) and infected (inoculated) seedlings at seven time points [1, 2, 3, 4, 8, and 12 weeks post-inoculation (wpi)] in a randomized design. The expression profiles of phenylalanine ammonia lyase (PAL), cinnamyl alcohol dehydrogenase (CAD), and peroxidase (POD) genes were monitored at 1, 2, and 3 wpi using real-time quantitative polymerase chain reaction...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28845776/self-heating-pasteurization-of-substrates-for-culinary-medicinal-mushrooms-cultivation-in-mexico
#14
Viviana Morales, Jose E Sánchez
The aim of this study was to evaluate a self-heating pasteurization technique in preparing substrates for mushroom production. Seven species were used: Agrocybe aegerita, Auricularia fuscosuccinea, Pleurotus djamor, P. eryngii, P. ostreatus, Lentinula edodes, and Ganoderma lucidum. They were cultivated on grass, corncob, wood shavings, and a mixture thereof. The self-heating technique allowed for pasteurization of 3 of the substrates (grass, corncob, and the mixture). The preheating chamber comprised a drawer placed under the pasteurization crate...
2017: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/28845774/a-validated-reverse-phase-hplc-method-for-quantitative-determination-of-ganoderic-acids-a-and-b-in-cultivated-strains-of-ganoderma-spp-agaricomycetes-indigenous-to-india
#15
M Ramakrishna, D Rajesh Babu, S S Veena, Meera Pandey, Nageswara Rao
Twenty isolates of Ganoderma spp. indigenous to India were used in this study. A reverse-phase high-performance liquid chromatography (HPLC) method was used to quantify 2 of the most bioactive triterpenes, ganoderic acid A (GAA) and ganoderic acid B (GAB), among the cultivated Ganoderma spp. The HPLC analysis was performed on an Agilent 1260 Infinity HPLC system with a Zorbax C18 column, using gradient elution of acetonitrile and 0.1% acetic acid. The detection wavelength was set at 254 nm, with a flow rate of 0...
2017: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/28845771/efficient-accumulation-and-in-vitro-antitumor-activities-of-triterpene-acids-from-submerged-batch-cultured-lingzhi-or-reishi-medicinal-mushroom-ganoderma-lucidum-agaricomycetes
#16
Xiao-Ling Wang, Zhong-Yang Ding, Yan Zhao, Gao-Qiang Liu, Guo-Ying Zhou
Triterpene acids are among the major bioactive constituents of lucidum. However, submerged fermentation techniques for isolating triterpene acids from G. lucidum have not been optimized for commercial use, and the antitumor activity of the mycelial triterpene acids needs to be further proven. The aim of this work was to optimize the conditions for G. lucidum culture with respect to triterpene acid production, scaling up the process, and examining the in vitro antitumor activity of mycelial triterpene acids...
2017: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/28822161/-synergistic-mechanism-of-traditional-chinese-medicine-based-on-target-combination-of-pept1-and-ppar%C3%AE
#17
Lian-Sheng Qiao, Yan-Kun Chen, Gang-Gang Luo, Fang Lu, Si-Jia Liu, Gong-Yu Li, Yan-Ling Zhang
Synergistic effect is main pharmacological mechanism of traditional Chinese medicine(TCM). The research method based on the key targets combination is an important method to explore the synergistic effect of TCM. Peptide transporter 1 (PepT1) is an essential target for drug uptake into the bloodstream, accounting for about 50% of the total transporter protein content from the small intestine. Peroxisome proliferator-activated receptor α(PPARα) is the lipid-lowering target of fibrates, which have a good hypolipidemic effect by activating PPARα...
June 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28802268/ornithine-decarboxylase-mediated-production-of-putrescine-influences-ganoderic-acid-biosynthesis-by-regulating-ros-in-ganoderma-lucidum
#18
Chen-Gao Wu, Jia-Long Tian, Rui Liu, Peng-Fei Cao, Tian-Jun Zhang, Ang Ren, Liang Shi, Ming-Wen Zhao
Putrescine is an important polyamine that participates in a variety of stress responses. Ornithine decarboxylase (ODC) is a key enzyme that catalyzes the biosynthesis of putrescine. A homolog of the gene encoding ODC was cloned from Ganoderma lucidum In the ODC-silenced strains, the transcript levels of the ODC gene and the putrescine content were significantly decreased. The ODC-silenced strains were more sensitive to oxidative stress. The content of ganoderic acid was increased by approximately 43-46% in the ODC-silenced strains...
August 11, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28800421/lanostane-type-triterpenoids-from-the-fruiting-body-of-ganoderma-calidophilum
#19
Sheng-Zhuo Huang, Qing-Yun Ma, Fan-Dong Kong, Zhi-Kai Guo, Cai-Hong Cai, Li-Li Hu, Li-Man Zhou, Qi Wang, Hao-Fu Dai, Wen-Li Mei, You-Xing Zhao
To search for active anti-cancer constituents in the fruiting body of Ganoderma calidophilum, we have successfully isolated four previously undescribed spiro-lactone lanostane triterpenoids (spiroganocalitones A-D), two previously undescribed lanostanoids (ganodecalones A and B) together with twenty-three known ones. The structures of the six previously undescribed compounds were elucidated based on 1D, 2D-NMR, and HRMS analyses. Ganoderone A showed moderate cytotoxic activity against K562, BEL7402, and SGC790 cell lines with IC50 values of 7...
August 8, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28798349/evaluation-on-quality-consistency-of-ganoderma-lucidum-dietary-supplements-collected-in-the-united-states
#20
Ding-Tao Wu, Yong Deng, Ling-Xiao Chen, Jing Zhao, Anton Bzhelyansky, Shao-Ping Li
Ganoderma lucidum is a well-known medicinal mushroom. At present, numerous G. lucidum products have emerged in the form of dietary supplements in the United States due to its various benefits. However, the quality consistency of these products based on their label ingredients has seldom been evaluated due to the lack of a suitable toolkit. In this study, 19 batches of products of G. lucidum (Red Reishi, Reishi), herbal/mushroom supplements purchased in the United States, were evaluated based on their bioactive components including triterpenes and polysaccharides by using chromatographic methods and saccharide mapping...
August 10, 2017: Scientific Reports
keyword
keyword
11602
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"