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Ganoderma

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https://www.readbyqxmd.com/read/29790031/effect-of-selenium-containing-biocomposites-from-medicinal-mushrooms-on-the-potato-ring-rot-causative-agent
#1
A I Perfileva, O M Tsivileva, Ya B Drevko, D N Ibragimova, O V Koftin
The impact of selenium biocomposites obtained from the medicinal macrobasidiomycetes Ganoderma lucidum, Grifola umbellata, Laetiporus sulphureus, Lentinula edodes, and Pleurotus ostreatus on the viability and biofilm formation capability of the phytopathogenic Gram-positive bacterium Clavibacter michiganensis ssp. sepedonicus (Spieck. et Kotth.) (Cms) was studied. Impairment of bacterial cell viability resulting from their incubation with biocomposites was shown. The decisive role of the composites' selenium component on the biological activity under question was established...
March 2018: Doklady Biological Sciences: Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections
https://www.readbyqxmd.com/read/29786938/inhibition-and-kinetic-studies-of-lignin-degrading-enzymes-of-ganoderma-boninense-by-naturally-occurring-phenolic-compounds
#2
Arthy Surendran, Yasmeen Siddiqui, Halimi Mohd Saud, Nusaibah Syd Ali, Sivakumar Manickam
AIM: Lignolytic (Lignin degrading) enzyme, from oil palm pathogen Ganoderma boninense Pat. (Syn G. orbiforme (Ryvarden), is involved in the detoxification and the degradation of lignin in the oil palm and is the rate-limiting step in the infection process of this fungus. Active inhibition of lignin degrading enzymes secreted by G. boninense by various naturally occurring phenolic compounds and estimation of efficiency on pathogen suppression was aimed at. METHODS AND RESULTS: In our work, ten naturally occurring phenolic compounds were evaluated for their inhibitory potential towards the lignolytic enzymes of G...
May 22, 2018: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29784301/two-new-farnesyl-phenolic-compounds-with-anti-inflammatory-activities-from-ganoderma-duripora
#3
Jie-Qing Liu, Chen-Lei Lian, Tian-Yong Hu, Cui-Fang Wang, Ying Xu, Lei Xiao, Zhi-Qiang Liu, Shu-Qi Qiu, Bao-Hui Cheng
Ganoderma fungi have long been used as a famous traditional medicine and food in country of East Asia. In this work, two new farnesyl phenolic compounds, ganoduriporols A and B (1 and 2), were isolated from the fruiting bodies of Ganoderma duripora, and their structures were elucidated using various spectroscopic methods. Anti-inflammatory activities were assayed and evaluated for the two compounds. Ganoduriporols A and B exhibited dose-dependent anti-inflammatory effects in RAW 264.7 cells. Furthermore, ganoduriporol A was demonstrated to inhibit the production of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6) and prostaglandin E2 (PGE2 ) through the suppression of COX-2, MAPK and NF-κB signaling pathway in LPS-induced macrophage cells...
October 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29783018/tumor-inhibitory-effects-of-intravesical-ganoderma-lucidum-instillation-in-the-syngeneic-orthotopic-mb49-c57-bladder-cancer-mice-model
#4
J W M Yuen, D S Y Mak, E S Chan, M D I Gohel, C F Ng
ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum (GL) has been traditionally used in oriental medicine as superior health tonic, and there are numerous scientific evidences of its antitumorigenic activities. AIM OF THE STUDY: To evaluate the intravesical chemopreventive effects of ethanol extract of GL (GLe) on bladder cancer. MATERIALS AND METHODS: Intravesical therapy is defined as the direct instillation of a liquid drug into bladder through a catheter...
May 18, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29777719/purification-and-identification-of-an-actinomycin-d-analogue-from-actinomycetes-associated-with-ganoderma-applanatum-via-magnetic-molecularly-imprinted-polymers-and-tandem-mass-spectrometry
#5
Chang-Gen Li, Bo Yuan, Meng-Meng Dong, Pin-Yu Zhou, Yu-Xin Hao, Ying-Ying Sun, Meng-Ke Xu, Dan Li, Guo-Yin Kai, Ji-Hong Jiang
Actinomycetes are main producers of antibiotics and targeted screening could improve the efficiency of discovering new drugs. This study describes, for the first time, the isolation of endophytic actinomycetes from the macrofungus Ganoderma applanatum. To increase the efficiency of screening, novel actinomycin D (Act D) molecularly-imprinted polymers were adsorbed to the surface of Fe3 O4 @SiO2 magnetic microspheres (MMIPs) and using in the isolation. A monolithic column prepared with magnetic molecularly imprinted polymers was employed to adsorb actinomycin D and its analogues for selective analysis and identification via MS/MS spectroscopy...
May 16, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29773009/cloning-and-characterization-of-promoters-of-the-fungal-immunomodulatory-protein-genes-from-ganoderma-spp-agaricomycetes-and-their-response-to-methyl-jasmonate-and-salicylic-acid
#6
Qi-Zhang Li, Yu-Zhou Chang, Kai-Qi Su, Xiao-Lei Wang, Xiao-Hui Bai, Xuan-Wei Zhou
Ganoderma mushrooms for medicinal use contain various bioactive compounds, but the genetic elements available for these medicinal mushrooms are still limited. In this study we cloned and analyzed the promoters of fungal immunomodulatory protein (FIP) genes from G. lucidum and G. atrum. FIP gene expression was induced by different concentrations of methyl jasmonate (MeJA) and salicylic acid (SA), and messenger RNA expression was detected by quantitative reverse-transcription polymerase chain reaction. The results provided 5' upstream sequences of FIP genes from G...
2018: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/29773007/cell-proliferation-and-dna-repair-ability-of-ganoderma-neo-japonicum-agaricomycetes-an-indigenous-medicinal-mushroom-from-malaysia
#7
Wee Cheat Tan, Umah Rani Kuppusamy, Chia Wei Phan, Vikineswary Sabaratnam
Ganoderma neo-japonicum is an annual polypore that grows on decaying bamboo in the forests of Malaysia. The indigenous Temuan tribe uses this species as a medicinal mushroom to cure fever and epilepsy and to improve body strength. The potential use of G. neo-japonicum in genoprotection and DNA repair was established using a single-cell gel electrophoresis (comet) assay. The effects of the ethanol and hot aqueous extracts from wild and cultivated basidiocarps, solid substrate-fermented (SSF) wheat grains, and mycelia via submerged culture on H2O2-damaged murine RAW264...
2018: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/29773006/antimelanogenesis-and-anti-inflammatory-activity-of-selected-culinary-medicinal-mushrooms
#8
Hazwani Mat Saad, Kae Shin Sim, Yee Shin Tan
Five culinary-medicinal mushrooms are commonly available in the Malaysian market: Agaricus bisporus (white and brown), Ganoderma lucidum, Hypsizygus marmoreus, Pleurotus floridanus, and P. pulmonarius. These species were selected for use in the current study, the aim of which was to investigate the antimelanogenesis and anti-inflammatory activity of these mushrooms in an attempt to evaluate their potential use in cosmeceuticals. Mushroom fruiting bodies were extracted with hot water, and the extracts were freeze-dried before testing...
2018: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/29771956/molecular-survey-of-basidiomycetes-and-divergence-time-estimation-an-indian-perspective
#9
Meghna Bhatt, Pankti Mistri, Ishita Joshi, Hemal Ram, Rinni Raval, Sruthi Thoota, Ankur Patel, Dhrupa Raval, Poonam Bhargava, Subhash Soni, Snehal Bagatharia, Madhvi Joshi
This study outlines the biodiversity of mushrooms of India. It reveals the molecular biodiversity and divergence time estimation of basidiomycetes from Gujarat, India. A total of 267 mushrooms were collected from 10 locations across the state. 225 ITS sequences were generated belonging to 105 species, 59 genera and 29 families. Phylogenetic analysis of Agaricaceae reveals monophyletic clade of Podaxis differentiating it from Coprinus. Further, the ancient nature of Podaxis supports the hypothesis that gasteroid forms evolved from secotioid forms...
2018: PloS One
https://www.readbyqxmd.com/read/29757712/genetic-variability-of-ganoderma-zonatum-infecting-palms-in-florida
#10
Monica L Elliott, Elizabeth A Des Jardin, Johana V Ortiz, Tommy Macias
Ganoderma zonatum is a lethal pathogen of palms (Arecaceae) in Florida (USA) because it degrades the wood of the lowest section of the palm trunk. This fungus is widespread throughout Florida, where it has been observed on over 60 species of palms. The authors examined the genetic variability of 25 isolates of G. zonatum obtained in Florida from 12 different palm species and representing 17 unique property locations in eight counties to determine if G. zonatum represents a species complex. The three genomic regions examined were the nuc rDNA ITS1-5...
March 2, 2018: Mycologia
https://www.readbyqxmd.com/read/29753871/combinatorial-usage-of-fungal-polysaccharides-from-cordyceps-sinensis-and-ganoderma-atrum-ameliorate-drug-induced-liver-injury-in-mice
#11
Songtao Fan, Xiaojun Huang, Sunan Wang, Chang Li, Zhihong Zhang, Mingyong Xie, Shaoping Nie
This study investigated the possible protective effect of combined fungal polysaccharides (CFP), consisting of Cordyceps sinensis polysaccharides (CSP) and Ganoderma atrum polysaccharides (PSG) with well-defined structural characteristics, against cyclophosphamide (CTX)-induced hepatotoxicity in mice. Our results indicated CFP effectively prevented the liver injury by decreasing toxicity markers (aspartate transaminase, alanine aminotransferase and alkaline phosphatase). Further biochemical and molecular analysis indicated CSP particularly inhibited the activation of Toll-like receptor 9 (TLR9) and its related inflammatory signals, including pro-inflammatory cytokines, inducible nitric oxide synthase, and cyclooxygenase-2 to modulate hepatic inflammation response...
May 10, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29748985/preparative-isolation-of-ganoderic-acid-s-ganoderic-acid-t-and-ganoderol-b-from-ganoderma-lucidum-mycelia-by-high-speed-counter-current-chromatography
#12
Na Feng, Yutian Wei, Jie Feng, Qingjiu Tang, Zhong Zhang, Jingsong Zhang, Han Wei
Ganoderic acid S, ganoderic acid T, and ganoderal B are the main bioactive triterpenes of Ganoderma lucidum. In this study, mycelia of Ganoderma lucidum were obtained by two-stage fermentation and then extracted by ethanol and petroleum ether sequentially to obtain crude triterpenes. The crude sample was further purified by recycling high-speed counter-current chromatography (HSCCC) with n-hexane: ethyl acetate: methanol: water (7:12:11:5, v/v/v/v) as the optimized two-phase solventsystem. 16.4 mg of ganoderol B with the purity of 90...
May 10, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29747629/in-vitro-evaluation-of-the-synergistic-antioxidant-and-anti-inflammatory-activities-of-the-combined-extracts-from-malaysian-ganoderma-lucidum-and-egyptian-chlorella-vulgaris
#13
Marwa M Abu-Serie, Noha H Habashy, Wafaa E Attia
BACKGROUND: Since oxidative stress and inflammation are two linked factors in the pathogenesis of several human diseases. Thus identification of effective treatment is of great importance. Edible mushroom and microalgae are rich in the effective antioxidant phytochemicals. Hence, their beneficial effects on oxidative stress-associated inflammation are extremely required to be investigated. METHODS: This study evaluated the functional constituents, antioxidant and anti-inflammatory activities of Malaysian Ganoderma lucidum aqueous extract (GLE) and Egyptian Chlorella vulgaris ethanolic extract (CVE)...
May 10, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29742702/spore-powder-of-ganoderma-lucidum-for-the-treatment-of-alzheimer-disease-a-pilot-study
#14
Guo-Hui Wang, Li-Hua Wang, Chen Wang, Li-Hong Qin
BACKGROUND: This study explored the feasible efficacy and safety of the Spore Powder of Ganoderma Lucidum (SPGL) for treating patients with Alzheimer disease (AD). METHODS: Forty-two eligible patients with AD were recruited. These patients were randomly allocated to an intervention group and a control group equally. The patients in the intervention group underwent SPGL, whereas the subjects in the control received placebo. All patients were treated for a total of 6 weeks...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29740229/enzymatic-extract-containing-lignin-peroxidase-immobilized-on-carbon-nanotubes-potential-biocatalyst-in-dye-decolourization
#15
Sabrina Feliciano Oliveira, José Maria Rodrigues da Luz, Maria Catarina Megumi Kasuya, Luiz Orlando Ladeira, Ary Correa Junior
The majority of the textile dyes are harmful to the environment and potentially carcinogenic. Among strategies for their exclusion, the treatment of dye contaminated wastewater with fungal extract, containing lignin peroxidase (LiP), may be useful. Two fungi isolates, Pleurotus ostreatus (PLO9) and Ganoderma lucidum (GRM117), produced the enzymatic extract by fermentation in the lignocellulosic residue, Jatropha curcas seed cake. The extracts from PLO9 and GRM117 were immobilized on carbon nanotubes and showed an increase of 18 and 27-fold of LiP specific activity compared to the free enzyme...
May 2018: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/29738972/steroids-from-ganoderma-sinense-as-new-natural-inhibitors-of-cancer-associated-mutant-idh1
#16
Mengzhu Zheng, Ruotian Tang, Yue Deng, Kaiyin Yang, Lixia Chen, Hua Li
Isocitrate dehydrogenase (IDH) is one of the key enzymes in the tricarboxylic acid cycle, and IDH mutations have been associated with many cancers, including glioblastoma, sarcoma, acute myeloid leukemia, etc. Three natural steroids 1-3 from Ganoderma sinense, a unique and rare edible-medicinal fungi in China, were found as potential IDH1 inhibitors by virtual ligand screening method. Among the three compounds, 3 showed the highest binding affinity to IDH1 with significant calculated binding free energy. Enzymatic kinetics demonstrated that 3 inhibited mutant enzyme in a noncompetitive manner...
April 30, 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29735945/hypouricemic-effect-of-2-5-dihydroxyacetophenone-a-computational-screened-bioactive-compound-from-ganoderma-applanatum-on-hyperuricemic-mice
#17
Danling Liang, Tianqiao Yong, Shaodan Chen, Yizhen Xie, Diling Chen, Xinxin Zhou, Dan Li, Muxia Li, Lu Su, Dan Zuo
Searching novel hypouricemic agents of high efficacy and safety has attracted a great attention. Previously, we reported the hypouricemic effect of Ganoderma applanatum , but its bioactives, was not referred. Herein, we report the hypouricemic effect of 2,5-dihydroxyacetophenone (DHAP), a compound screened from Ganoderma applanatum computationally. Serum parameters, such as uric acid (SUA), xanthine oxidase (XOD) activity, blood urea nitrogen (BUN), and creatinine were recorded. Real-time reverse transcription PCR (RT-PCR) and Western blot were exploited to assay RNA and protein expressions of organic anion transporter 1 (OAT1), glucose transporter 9 (GLUT9), uric acid transporter 1 (URAT1), and gastrointestinal concentrative nucleoside transporter 2 (CNT2)...
May 7, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29731312/use-of-lignocellulosic-wastes-of-pecan-carya-illinoinensis-in-the-cultivation-of-ganoderma-lucidum
#18
María Virginia Ozcariz-Fermoselle, Raúl Fraile-Fabero, Tomás Girbés-Juan, Oscar Arce-Cervantes, Juan Andrés Oria de Rueda-Salgueiro, Anabela Marisa Azul
BACKGROUND: The wastes of pecan nut (Carya illinoinensis (Wangenh.) K. Koch) production are increasing worldwide and have high concentrations of tannins and phenols. AIMS: To study the biodegradation of lignocellulosic wastes of pecan used as solid substrate for the cultivation of the white-rot fungus Ganoderma lucidum (Curtis) P. Karst. METHODS: Six formulations of pecan wastes were used as solid substrate: pecan shells (PS100), pecan pericarp (PP100), pecan wood-chips (PB100), and the combinations PS50+PP50, PB50+PS50 and PB50+PP50...
May 3, 2018: Revista Iberoamericana de Micología
https://www.readbyqxmd.com/read/29722004/meroterpenoids-from-ganoderma-species-a-review-of-last-five-years
#19
REVIEW
Xingrong Peng, Minghua Qiu
Meroterpenoids are hybrid natural products that partially originate from the terpenoid pathway. Ganoderma meroterpenoids (GMs) are a type of meroterpenoids containing a 1,2,4-trisubstituted phenyl and a polyunsaturated terpenoid part. Over last 5 years, great efforts have been made to conduct phytochemistry research on the genus Ganoderma, which have led to the isolation and identification of a number of GMs. These newly reported GMs showed diverse structures and a wide range of biological activities. This review gives an overview of new GMs from genus Ganoderma and their biological activities and biosynthetic pathway, focusing on the period from 2013 until 2018...
May 2, 2018: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/29721500/antioxidant-enzyme-activities-and-secondary-metabolite-profiling-of-oil-palm-seedlings-treated-with-combination-of-npk-fertilizers-infected-with-ganoderma-boninense
#20
Mahbod Sahebi, Mohamed M Hanafi, Hasmah Mohidin, M Y Rafii, Parisa Azizi, Abu Seman Idris, A Fariz, Rambod Abiri, Sima Taheri, Mehdi Moradpoor
Oil palm ( Elaeis guineensis Jacq) is one of the major sources of edible oil. Reducing the effect of Ganoderma, main cause of basal stem rot (BSR) on oil palm, is the main propose of this study. Understanding the oil palm defense mechanism against Ganoderma infection through monitoring changes in the secondary metabolite compounds levels before/after infection by Ganoderma under different fertilizing treatment is required. Oil palm requires macro- and microelements for growth and yield. Manipulating the nutrient for oil palm is a method to control the disease...
2018: BioMed Research International
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