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https://www.readbyqxmd.com/read/28720793/genome-wide-identification-and-characterization-of-natural-antisense-transcripts-by-strand-specific-rna-sequencing-in-ganoderma-lucidum
#1
Junjie Shao, Haimei Chen, Dan Yang, Mei Jiang, Hui Zhang, Bin Wu, Jianqin Li, Lichai Yuan, Chang Liu
Ganoderma lucidum is a white-rot fungus best-known for its medicinal and ligninolytic activities. To discover the underlying genes responsible for these activities, we identified and characterized the natural antisense transcripts (NATs) using strand-specific (ss) RNA-seq data obtained from the mycelia, primordia and fruiting bodies. NATs were identified using a custom pipeline and then subjected to functional enrichment and differential expression analyses. A total of 1613 cis- and 244 trans- sense and antisense transcripts were identified...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28709639/ganoderma-triterpenes-retard-renal-cyst-development-by-downregulating-ras-mapk-signaling-and-promoting-cell-differentiation
#2
Limin Su, Liying Liu, Yingli Jia, Lei Lei, Jiangfeng Liu, Shuai Zhu, Hong Zhou, Ruoyun Chen, Hua Ann Jenny Lu, Baoxue Yang
Autosomal dominant polycystic kidney disease (ADPKD) is a common monogenetic disease characterized by the progressive development of renal cysts with further need for effective therapy. Here our aim was to investigate the effect of Ganoderma triterpenes (GT) on the development of kidney cysts. Importantly, GT attenuated cyst development in two mouse models of ADPKD with phenotypes of severe cystic kidney disease. Assays for tubulogenesis showed that GT promoted epithelial tubule formation in MDCK cells, suggesting a possible effect on epithelial cell differentiation...
July 11, 2017: Kidney International
https://www.readbyqxmd.com/read/28702429/wild-mushrooms-a-potential-source-of-nutritional-and-antioxidant-attributes-with-acceptable-toxicity
#3
Sumaira Sharif, Muhammad Shahid, Muhammad Mushtaq, Sumia Akram, Ayoub Rashid
This paper describes in detail proximate composition, nutritional profile, phytochemical constituents, antioxidant activities, antimicrobial potential, and antihemolytic activity (towards human erythrocytes) of various fractions of wild Ganoderma lucidum. Proximate analysis established that wild G. lucidum comprises about 87.02±5.45% of moisture, and the remaining part is a rich source of proteins (8.59±0.37%), crude fiber (54.21±1.2%), and carbohydrate (35.16%) with smaller fat content (3.33 %). Similarly, phytochemical screening revealed the presence of flavonoids (217...
June 2017: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/28695905/corrigendum-ganoderma-lucidum-reduces-obesity-in-mice-by-modulating-the-composition-of-the-gut-microbiota
#4
Chih-Jung Chang, Chuan-Sheng Lin, Chia-Chen Lu, Jan Martel, Yun-Fei Ko, David M Ojcius, Shun-Fu Tseng, Tsung-Ru Wu, Yi-Yuan Margaret Chen, John D Young, Hsin-Chih Lai
This corrects the article DOI: 10.1038/ncomms8489.
July 11, 2017: Nature Communications
https://www.readbyqxmd.com/read/28695802/effect-of-ganoderma-lucidum-preparation-on-the-behavior-biochemistry-and-autoimmune-parameters-of-mouse-models-of-app-ps1-double-transgenic-alzheimer-s-disease
#5
Chuan Qin, Shanqiu Wu, Baosheng Chen, Xiaoxian Wu, Kunyao Qu, Junmin Liu, Guifang Zhang, Yanfeng Xu, Shunli Shu, Lihua Sun, Yanhong Li, Hua Zhu, Lan Huang, Chunmei Ma, Yuhuan Xu, Yunlin Han, Yaozeng Lu
Objective To evaluate the efficacy of Ganoderma lucidum preparation on the behaviors,biochemistry,and autoimmunity parameters of mouse models of APP/PS-1 double transgenic Alzheimer's disease(AD).Methods A total of 44 4-month-old APP/PS-1 double transgenic AD mice were randomly divided into AD model group,Aricept group,Ganoderma lucidum middle-dose(LZ-M)group,and Ganoderma lucidum high-dose(LZ-H)group,with 11 mice in each group.In addition,10 4-month-old C57BL/6 mice were used as the control group.Water maze test was conducted to observe the behavior changes,and the protein expressions in brain tissues were detected by Western blot analysis...
June 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/28681206/protective-effect-of-ganoderma-lucidum-polysaccharide-against-carbon-tetrachloride-induced-hepatic-damage-in-precision-cut-carp-liver-slices
#6
Yingjuan Liu, Chunyun Zhang, Jinliang Du, Rui Jia, Liping Cao, Galina Jeney, Hiroki Teraoka, Pao Xu, Guojun Yin
The aim of the present study was to investigate the protective effects of Ganoderma lucidum polysaccharide (GLPS) against carbon tetrachloride (CCl4)-induced hepatotoxicity in vitro in common carp. Precision-cut liver slices (PCLSs), which closely resemble the organ from which they are derived, were employed as an in vitro model system. GLPS (0.1, 0.3, and 0.6 mg/ml) was added to PCLS culture system before the exposure to 12 mM CCl4. The supernatants and slices were collected to detect molecular and biochemical responses to CCl4 and PCLS treatments...
July 5, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/28661219/feeding-of-the-water-extract-from-ganoderma-lingzhi-to-rats-modulates-secondary-bile-acids-intestinal-microflora-mucins-and-propionate-important-to-colon-cancer
#7
Yongshou Yang, Dwi Eva Nirmagustina, Thanutchaporn Kumrungsee, Yukako Okazaki, Hiroyuki Tomotake, Norihisa Kato
Consumption of reishi mushroom has been reported to prevent colon carcinogenesis in rodents, although the underlying mechanisms remain unclear. To investigate this effect, rats were fed a high-fat diet supplemented with 5% water extract from either the reishi mushroom (Ganoderma lingzhi) (WGL) or the auto-digested reishi G. lingzhi (AWGL) for three weeks. Both extracts markedly reduced fecal secondary bile acids, such as lithocholic acid and deoxycholic acid (colon carcinogens). These extracts reduced the numbers of Clostridium coccoides and Clostridium leptum (secondary bile acids-producing bacteria) in a per g of cecal digesta...
June 29, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28657576/nortriterpenoids-from-the-fruiting-bodies-of-the-mushroom-ganoderma-resinaceum
#8
Xian-Qiang Chen, Ling-Xiao Chen, Jing Zhao, Yu-Ping Tang, Shao-Ping Li
Ganoderma resinaceum is usually used as ethnomedicine for immune-regulation, hyperglycemia, and liver disease. To date, only a few chemical constituents have been reported from G. resinaceum. In this study, fifteen nortriterpenoids including six new nortriterpenoids (1-6) and nine known analogs (7-15), were separated and purified from the fruiting bodies of G. resinaceum. New compounds were identified as lucidone I (1), lucidone J (2), lucidone K (3), lucidone I (4), ganosineniol B (5), and ganosineniol C (6), based on analysis of extensive spectroscopic data (high resolution mass spectrometry (HRMS), nuclear magnetic resonance (NMR), infrared (IR), and ultraviolet (UV))...
June 28, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28653896/ganoderma-lucidum-targeting-lung-cancer-signaling-a-review
#9
REVIEW
Balraj Singh Gill, Navgeet, Sanjeev Kumar
Lung cancer causes huge mortality to population, and pharmaceutical companies require new drugs as an alternative either synthetic or natural targeting lung cancer. The conventional therapies cause side effects, and therefore, natural products are used as a therapeutic candidate in lung cancer. Chemical diversity among natural products highlights the impact of evolution and survival of fittest. One such neglected natural product is Ganoderma lucidum used for promoting health and longevity for a longer time...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28618650/anti-amnesic-effects-of-ganoderma-species-a-possible-cholinergic-and-antioxidant-mechanism
#10
Ravneet Kaur, Varinder Singh, Richa Shri
Mushrooms are valued for their nutritional as well as medicinal properties. Ganoderma species are used traditionally to treat neurological disorders but scientific evidence for this is insufficient. The present study was designed to systematically evaluate the anti-amnesic effect of selected Ganoderma species i.e. G. mediosinense and G. ramosissimum. Extracts of selected mushroom species were evaluated for their antioxidant activity and acetylcholinesterase (AChE) inhibition using in-vitro assays (DPPH and Ellman tests respectively)...
August 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28618378/simultaneously-upgrading-biogas-and-purifying-biogas-slurry-using-cocultivation-of-chlorella-vulgaris-and-three-different-fungi-under-various-mixed-light-wavelength-and-photoperiods
#11
Weixing Cao, Xue Wang, Shiqing Sun, Changwei Hu, Yongjun Zhao
In order to purify biogas slurry and biogas simultaneously, three different fungi, Pleurotus geesteranus (P. geesteranus), Ganoderma lucidum (G. lucidum), and Pleurotus ostreatus (P. ostreatus) were pelletized with Chlorella vulgaris (C. vulgaris). The results showed that the optimal light wavelength ratio for red:blue was 5:5 for these three different fungi-assisted C. vulgaris, resulting in higher specific growth rate as well as nutrient and CO2 removal efficiency compared with other ratios. G. lucidum/C...
October 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28608696/immunomodulatory-activity-of-ganoderma-atrum-polysaccharide-on-purified-t-lymphocytes-through-ca-2-can-and-mitogen-activated-protein-kinase-pathway-based-on-rna-sequencing
#12
Quan-Dan Xiang, Qiang Yu, Hui Wang, Ming-Ming Zhao, Shi-Yu Liu, Shao-Ping Nie, Ming-Yong Xie
Our previous study has demonstrated that Ganoderma atrum polysaccharide (PSG-1) has immunomodulatory activity on spleen lymphocytes. However, how PSG-1 exerts its effect on purified lymphocytes is still obscure. Thus, this study aimed to investigate the immunomodulatory activity of PSG-1 on purified T lymphocytes and further elucidate the underlying mechanism based on RNA sequencing (RNA-seq). Our results showed that PSG-1 promoted T lymphocytes proliferation and increased the production of IL-2, IFN-γ, and IL-12...
June 26, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28606348/about-ganoderma-boninense-in-oil-palm-plantations-of-sumatra-and-peninsular-malaysia-ancient-population-expansion-extensive-gene-flow-and-large-scale-dispersion-ability
#13
Maxime Mercière, Romain Boulord, Catherine Carasco-Lacombe, Christophe Klopp, Yang-Ping Lee, Joon-Sheong Tan, Sharifah S R Syed Alwee, Alba Zaremski, Hubert De Franqueville, Frédéric Breton, Létizia Camus-Kulandaivelu
Wood rot fungi form one of the main classes of phytopathogenic fungus. The group includes many species, but has remained poorly studied. Many species belonging to the Ganoderma genus are well known for causing decay in a wide range of tree species around the world. Ganoderma boninense, causal agent of oil palm basal stem rot, is responsible for considerable yield losses in Southeast Asian oil palm plantations. In a large-scale sampling operation, 357 sporophores were collected from oil palm plantations spread over peninsular Malaysia and Sumatra and genotyped using 11 SSR markers...
June 2017: Fungal Biology
https://www.readbyqxmd.com/read/28605335/in-vitro-expression-of-toll-like-receptors-and-proinflammatory-molecules-induced-by-ergosta-7-22-dien-3-one-isolated-from-a-wild-mexican-strain-of-ganoderma-oerstedii-agaricomycetes
#14
Angel Ramos-Ligonio, Aracely López-Monteon, Maria de la Soledad Lagunes-Castro, Jorge Suarez-Medellin, Cesar Espinoza, Guillermo Mendoza, Angel Trigos
Compounds showing pharmacological activity on the immune system are of interest because of their therapeutic potential in the treatment of many diseases. However, data from primary human immune cells and in vivo studies are limited. The aim of this study was to analyze the ability to induce the expression of Toll-like receptors (TLRs) and proinflammatory molecules on cells involved in the immune system using the compound ergosta-7,22-dien-3- one, isolated from a wild Mexican strain of Ganoderma oerstedii. According to our study, ergosta-7,22-dien-3-one did not present any cytotoxic effect on HeLa or J774A...
2017: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/28603120/enzyme-inhibitory-antifungal-antibacterial-and-hemolytic-potential-of-various-fractions-of-colebrookia-oppositifolia
#15
Tauheeda Riaz, Muhammad Athar Abbasi, Azizur Rehman, Sabahat Zahra Siddiqui, Muhammad Shahid, Hina Fatima, Muhammad Ashraf, Syeda Abida Ejaz, Zahid Ghulam Rasool, Ghulam Hasan Abbasi
The purpose of the present investigation was to assess the enzyme inhibition, antifungal, antibacterial and hemolytic activities of various fractions of Colebrookia oppositifolia Smith. The MeOH extract of plant was dissolved in dist. water and partitioned with n-hexane, CHCl3, EtOAc and n-BuOH sequentially. Enzyme inhibition studies were done against four enzymes i.e. α-glucosidase, butyrylcholinesterase, acetyl cholinesterase and lipoxygenase. Ethyl acetate fraction possessed very good activity against α-glucosidase (IC50 57...
January 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28592650/identification-of-ganoderma-disease-resistance-loci-using-natural-field-infection-of-an-oil-palm-multiparental-population
#16
Sébastien Tisné, Virginie Pomiès, Virginie Riou, Indra Syahputra, Benoît Cochard, Marie Denis
Multi-parental populations are promising tools for identifying quantitative disease resistance loci. Stem rot caused by Ganoderma boninense is a major threat to palm oil production, with yield losses of up to 80% prompting premature replantation of palms. There is evidence of genetic resistance sources, but the genetic architecture of Ganoderma resistance has not yet been investigated. This study aimed to identify Ganoderma resistance loci using an oil palm multi-parental population derived from nine major founders of ongoing breeding programs...
June 7, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28588565/diversity-of-ligninolytic-enzymes-and-their-genes-in-strains-of-the-genus-ganoderma-applicable-for-biodegradation-of-xenobiotic-compounds
#17
Giselle Torres-Farradá, Ana M Manzano León, François Rineau, Lucía L Ledo Alonso, María I Sánchez-López, Sofie Thijs, Jan Colpaert, Miguel Ramos-Leal, Gilda Guerra, Jaco Vangronsveld
White-rot fungi (WRF) and their ligninolytic enzymes (laccases and peroxidases) are considered promising biotechnological tools to remove lignin related Persistent Organic Pollutants from industrial wastewaters and contaminated ecosystems. A high diversity of the genus Ganoderma has been reported in Cuba; in spite of this, the diversity of ligninolytic enzymes and their genes remained unexplored. In this study, 13 native WRF strains were isolated from decayed wood in urban ecosystems in Havana (Cuba). All strains were identified as Ganoderma sp...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28572880/effect-of-medicinal-mushrooms-on-blood-cells-under-conditions-of-diabetes-mellitus
#18
REVIEW
Taras Vitak, Borys Yurkiv, Solomon Wasser, Eviatar Nevo, Natalia Sybirna
Diabetes mellitus (DM) is the third most common non-infectious disease leading to early disability and high mortality. Moreover, the number of patients is growing every year. The main symptom of DM is hyperglycemia. Increased levels of blood glucose activate polyol, hexosamine, and protein kinase metabolic pathways cause the intensification of non-enzymatic glycosylation and nitration of macromolecules. This, in turn, leads to the development of oxidative and nitrative stresses and secondary complications, such as different kinds of micro- and macroangiopathies...
May 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28543056/cloning-and-analysis-of-the-glwc-1-and-glwc-2-genes-encoding-putative-blue-light-photoreceptor-from-ganoderma-lucidum
#19
Xinran Xu, Xiangdong Chen, Wumengxiao Yu, Yu Liu, Weiwei Zhang, Jin Lan
Blue light plays an important role during the growth of Ganoderma lucidum, one of the best-known medicinal macrofungi in China. In the present study, we cloned Glwc-1 and Glwc-2, the homologue of the blue light photoreceptors Ncwc-1 and Ncwc-2 of Neurospora crassa, from G. lucidum. The deduced amino acid sequence of Glwc-1 contained the similar function domains as NcWC-1 including LOV, PAS B, PAS C, and PAC domains. The deduced amino acid sequence of Glwc-2 contained PAS domain and GATA-type zinc finger (Znf) domain as well as NcWC-2...
May 23, 2017: Journal of Basic Microbiology
https://www.readbyqxmd.com/read/28536459/a-novel-polycyclic-meroterpenoid-with-aldose-reductase-inhibitory-activity-from-medicinal-mushroom-ganoderma-leucocontextum
#20
Jinjin Zhang, Ke Ma, Hongyu Chen, Kai Wang, Weiping Xiong, Li Bao, Hongwei Liu
No abstract text is available yet for this article.
May 24, 2017: Journal of Antibiotics
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