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https://www.readbyqxmd.com/read/28543056/cloning-and-analysis-of-the-glwc-1-and-glwc-2-genes-encoding-putative-blue-light-photoreceptor-from-ganoderma-lucidum
#1
Xinran Xu, Xiangdong Chen, Wumengxiao Yu, Yu Liu, Weiwei Zhang, Jin Lan
Blue light plays an important role during the growth of Ganoderma lucidum, one of the best-known medicinal macrofungi in China. In the present study, we cloned Glwc-1 and Glwc-2, the homologue of the blue light photoreceptors Ncwc-1 and Ncwc-2 of Neurospora crassa, from G. lucidum. The deduced amino acid sequence of Glwc-1 contained the similar function domains as NcWC-1 including LOV, PAS B, PAS C, and PAC domains. The deduced amino acid sequence of Glwc-2 contained PAS domain and GATA-type zinc finger (Znf) domain as well as NcWC-2...
May 23, 2017: Journal of Basic Microbiology
https://www.readbyqxmd.com/read/28536459/a-novel-polycyclic-meroterpenoid-with-aldose-reductase-inhibitory-activity-from-medicinal-mushroom-ganoderma-leucocontextum
#2
Jinjin Zhang, Ke Ma, Hongyu Chen, Kai Wang, Weiping Xiong, Li Bao, Hongwei Liu
No abstract text is available yet for this article.
May 24, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28530827/overexpression-of-the-squalene-epoxidase-gene-alone-and-in-combination-with-the-3-hydroxy-3-methylglutaryl-coenzyme-a-gene-increases-ganoderic-acid-production-in-ganoderma-lingzhi
#3
De-Huai Zhang, Lu-Xi Jiang, Na Li, Xuya Yu, Peng Zhao, Tao Li, Jun-Wei Xu
The squalene epoxidase (SE) gene from the biosynthetic pathway of ganoderic acid (GA) was cloned and overexpressed in Ganoderma lingzhi. The strain that overexpressed the SE produced approximately 2 times more GA moleculars than the wild-type (WT) strain. Moreover, SE overexpression up-regulated lanosterol synthase gene expression in the biosynthetic pathway. These results indicated that SE stimulates GA accumulation. Then, the SE and 3-hydroxy-3-methylglutaryl coenzyme A (HMGR) genes were simultaneously overexpressed in G...
May 22, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28527898/triterpenes-and-meroterpenes-from-ganoderma-lucidum-with-inhibitory-activity-against-hmgs-reductase-aldose-reductase-and-%C3%AE-glucosidase
#4
Baosong Chen, Jin Tian, Jinjin Zhang, Kai Wang, Li Liu, Bo Yang, Li Bao, Hongwei Liu
Seven new compounds including four lanostane triterpenoids, lucidenic acids Q-S (1-3) and methyl ganoderate P (4), and three triterpene-farnesyl hydroquinone conjugates, ganolucinins A-C (5-7), one new natural product ganomycin J (8), and 73 known compounds (9-81) were isolated from fruiting bodies of Ganoderma lucidum. The structures of the compounds 1-8 were determined by spectroscopic methods. Bioactivities of compounds isolated were assayed against HMG-CoA reductase, aldose reductase, α-glucosidase, and PTP1B...
May 17, 2017: Fitoterapia
https://www.readbyqxmd.com/read/28510717/fast-population-growth-in-physogastry-reproduction-of-luciaphorus-perniciosus-acari-pygmephoridae-at-different-temperatures
#5
Prapassorn Bussaman, Chirayu Sa-Uth, Angsumarn Chandrapatya, Remzi Atlihan, Ayhan Gökçe, Pavel Saska, Hsin Chi
Luciaphorus perniciosus Rack is one of the most serious pests of several cultivated mushroom species including Ganoderma lucidum (Fr.), Flammulina velutipes Karst., Auricularia polytricha (Mont.) Saac., Lentinus polychrous Lev., and Lentinus squarrosulus (Mont.) Singer in Thailand. Adult female Lu. perniciosus produce offspring inside their physogastric hysterosomas, with all embryos developing through to the adult stage while remaining in the abdomen. Once the abdomen ruptures, the female parent dies and the offspring consisting of mostly fertilized female adults along with a few male adults continue to emerge from the cadaver of the mother for a period of several days...
May 16, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28508676/two-new-compounds-from-the-fruiting-bodies-of-ganoderma-philippii
#6
Shuang Yang, Qing-Yun Ma, Fan-Dong Kong, Qing-Yi Xie, Sheng-Zhuo Huang, Li-Man Zhou, Hao-Fu Dai, Zhi-Fang Yu, You-Xing Zhao
Two new compounds, philippin (1) and 3β,9α,14α-trihydroxy-(22E,24R)-ergost-22-en-7-one (2), were isolated from the fruiting bodies of Ganoderma philippii. Their structures were elucidated on the basis of the spectroscopic technologies, including 1D and 2D NMR as well as MS. The bioassay of inhibitory activity against acetylcholinesterase (AChE) showed compound 1 exhibited weak inhibitory activity against AChE.
May 16, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28504879/antitubercular-activity-of-mycelium-associated-ganoderma-lanostanoids
#7
Masahiko Isaka, Panida Chinthanom, Malipan Sappan, Sumalee Supothina, Vanicha Vichai, Kannawat Danwisetkanjana, Thitiya Boonpratuang, Kevin D Hyde, Rattaket Choeyklin
In a continuation of our research into antitubercular lanostane triterpenoids from submerged cultures of Ganoderma species, three strains, Ganoderma orbiforme BCC 22325, Ganoderma sp. BCC 60695, and Ganoderma australe BCC 22314, have been investigated. Fourteen new lanostane triterpenoids, together with 35 known compounds, were isolated. Antitubercular activities of these mycelium-associated Ganoderma lanostanoids against Mycobacterium tuberculosis H37Ra were evaluated. Taken together with the assay data of previously isolated compounds, structure-activity relationships of the antitubercular activity are proposed...
May 15, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28496309/effect-of-electromagnetic-fields-and-antioxidants-on-the-trace-element-content-of-rat-teeth
#8
Mehmet Sinan Dogan, Mehmet Cihan Yavas, Yasemin Yavuz, Sait Erdogan, İsmail Yener, İbrahim Simsek, Zeki Akkus, Veysel Eratilla, Abdulsamet Tanik, Mehmet Zulkuf Akdag
The purpose of this study was to examine the possible effect of extremely low-frequency electromagnetic fields (ELF-EMFs), from a high-voltage source, on rat teeth in terms of changes in trace elements (TEs) and the effect of antioxidants (melatonin [MLT] and Ganoderma lucidum [GL]) in counteracting these effects. We used adult male Wistar albino rats with a mean weight of 250-300 g and divided the rats into eight groups. The groups were subjected to an ELF-EMF that was applied with a high-voltage line for 8 hours/day for 26 days (Groups I, II, and III) or 52 days (Groups V, VI, and VII)...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28491940/data-on-eleven-sesquiterpenoids-from-the-cultured-mycelia-of-ganoderma-capense
#9
Zhen Tan, Jinlian Zhao, Jimei Liu, Min Zhang, Ridao Chen, Kebo Xie, Jungui Dai
The data included in this paper are associated with the research article entitled "Sesquiterpenoids from the cultured mycelia of Ganoderma capense" [1]. (1)H NMR, (13)C NMR, DEPT, HSQC, (1)H-(1)H COSY, HMBC, NOESY, HRESIMS, and IR spectra of Ganodermanol A-H (1-11), together with Mo2(AcO)4-induced CD spectrum of Ganodermanol A, CD spectra of Ganodermanol D-E were included in the Data in Brief article. In addition, the cytotoxicities and anti-HIV-1 activity of isolated compounds were also included in the Data in Brief article...
June 2017: Data in Brief
https://www.readbyqxmd.com/read/28484937/effects-of-ganoderma-lucidum-shell-broken-spore-on-oxidative-stress-of-the-rabbit-urinary-bladder-using-an-in-vivo-model-of-ischemia-reperfusion
#10
Robert M Levin, Li Xia, Wu Wei, Catherine Schuler, Robert E Leggett, Alpha D-Y Lin
Oxidative stress plays an important role in specific disease pathophysiology and the aging process. In the history of human kind, many herbs were utilized for disease prevention and anti-aging treatment. However, there are few direct evidences provided by modern laboratory technology. The current study was designed to evaluate Ganoderma Lucidum's (GL) ability to reduce the damage from in vivo ischemia/reperfusion (I/R) using a rabbit model of I/R that has been effectively utilized to prove the effects of drugs and supplements to reduce oxidative stress...
May 8, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28473815/gel-based-purification-and-biochemical-study-of-laccase-isozymes-from-ganoderma-sp-and-its-role-in-enhanced-cotton-callogenesis
#11
Amit Kumar, Deepti Singh, Krishna K Sharma, Sakshi Arora, Amarjeet K Singh, Sarvajeet S Gill, Barkha Singhal
Basidiomycetous fungi, Ganoderma lucidum MDU-7 and Ganoderma sp. kk-02 secreted multiple laccase isozymes under diverse growth condition. Aromatic compounds and metal salts were also found to regulate the differential expression of laccase isozymes from both the Ganoderma sp. Laccase isozymes induced in the presence of copper from G. lucidum MDU-7 were purified by gel-based (native-PAGE) purification method. The purity of laccase isozymes was checked by zymogram and SDS-PAGE. The SDS-PAGE of purified proteins confirmed the multimeric nature of laccase isozymes...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28438681/immobilized-lignin-peroxidase-from-ganoderma-lucidum-ibl-05-with-improved-dye-decolorization-and-cytotoxicity-reduction-properties
#12
Raheela Shaheen, Muhammad Asgher, Fatima Hussain, Haq Nawaz Bhatti
Use of free microbial enzymes for bioremediation and other industrial applications has several disadvantages like low stability and non-reusability in repeated batch operations. Immobilized enzymes are stable, recoverable and reusable in industrial processes. In this scenario G. lucidum IBL-05 LiP was entrapped in Ca-alginate beads using optimum concentrations of Na-alginate (4%), calcium chloride (0.2M) and glutraldehyde (0.02%). Optimum pH (pH 5) and temperature (55°C) for entrapped LiP were improved as compared to free LiP...
April 21, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28435030/the-mitogen-activated-protein-kinase-glslt2-regulates-fungal-growth-fruiting-body-development-cell-wall-integrity-oxidative-stress-and-ganoderic-acid-biosynthesis-in-ganoderma-lucidum
#13
Guang Zhang, Zehua Sun, Ang Ren, Liang Shi, Dengke Shi, Xiongbiao Li, Mingwen Zhao
The mitogen-activated protein kinases (MAPKs) are crucial signaling instruments in eukaryotes that play key roles in regulating fungal growth, development, and secondary metabolism and in adapting to the environment. In this study, we characterized an Slt2-type MAPK in Ganoderma lucidum, GlSlt2, which was transcriptionally induced during the primordium and fruiting body stages. RNA interference was used to examine the function of GlSlt2. Knockdown of GlSlt2 caused defects in growth and increased hyphal branching as well as hypersensitivity to cell wall-disturbing substances...
April 18, 2017: Fungal Genetics and Biology: FG & B
https://www.readbyqxmd.com/read/28433170/structural-characterization-and-immuno-enhancing-activity-of-a-highly-branched-water-soluble-%C3%AE-glucan-from-the-spores-of-ganoderma-lucidum
#14
Yatao Wang, Yanfang Liu, Huazheng Yu, Shuai Zhou, Zhong Zhang, Di Wu, Mengqiu Yan, Qingjiu Tang, Jingsong Zhang
A water soluble β-glucan (GLSWA-I) with a weight average molecular weight ∼1.57×10(5)g/mol, isolated from the aqueous extract of the broken cellular wall Ganoderma lucidum spores, was purified by anion-exchange and gel-permeation chromatography. The immunological activity test in vivo showed that GLSWA-I could significantly promote dinitrochlorobenzene (DNCB) induced delayed-type ear swelling in mice. Based on the monosaccharides composition analysis, methylation analysis, IR, 1D and 2D NMR spectroscopy, the repeating unit of polysaccharide GLSWA-I was elucidated as follows...
July 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28427938/ganoderma-lucidum-reishi-suppresses-proliferation-and-migration-of-breast-cancer-cells-via-inhibiting-wnt-%C3%AE-catenin-signaling
#15
Yu Zhang
The medical mushroom Ganoderma lucidum (Reishi), a traditional Chinese medicine, has exhibited a promising anti-cancer effect. However, the molecular mechanism of its action on cancer cells remains unclear. Aberrant activation of Wnt/β-catenin signaling pathway is the cause of many types of cancer, including breast cancer. Here we investigated the effect of Reishi on Wnt/β-catenin signaling pathway and elucidated the molecular mechanism of its function in inhibiting breast cancer cells. We found that Reishi blocked Wnt/β-catenin signaling through inhibiting the phosphorylation of Wnt co-receptor LRP6...
April 17, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28422185/improved-ganoderic-acids-production-in-ganoderma-lucidum-by-wood-decaying-components
#16
Yanru Hu, Shakeel Ahmed, Jiawei Li, Biaobiao Luo, Zengyan Gao, Qiyun Zhang, Xiaohua Li, Xuebo Hu
Ganoderma lucidum is a legendary Traditional Chinese Medicine (TCM) over a few thousands of years and one kind of its major active components are Ganoderic acids (GAs). GAs are largely produced in the mushroom primordium and fruiting body but much less in mycelium stage. However, little is known on the underlying regulatory mechanism. As a saprophytic fungus, G. lucidum solely obtains nutrients by wood decaying. Wood in general contains sophisticated chemical components with diverse structural units. To explore a strategy that extensively leads to GAs induction in the submerged liquid fermentation, all chemical components that might be possibly from the wood decaying were tested individually as GAs inducers...
April 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28421142/plackett-burman-design-for-rgilcc1-laccase-activity-enhancement-in-pichia-pastoris-concentrated-enzyme-kinetic-characterization
#17
Edwin D Morales-Álvarez, Claudia M Rivera-Hoyos, Ángela M Cardozo-Bernal, Raúl A Poutou-Piñales, Aura M Pedroza-Rodríguez, Dennis J Díaz-Rincón, Alexander Rodríguez-López, Carlos J Alméciga-Díaz, Claudia L Cuervo-Patiño
Laccases are multicopper oxidases that catalyze aromatic and nonaromatic compounds with concomitant reduction of molecular oxygen to water. They are of great interest due to their potential biotechnological applications. In this work we statistically improved culture media for recombinant GILCC1 (rGILCC1) laccase production at low scale from Ganoderma lucidum containing the construct pGAPZαA-GlucPost-Stop in Pichia pastoris. Temperature, pH stability, and kinetic parameter characterizations were determined by monitoring concentrate enzyme oxidation at different ABTS substrate concentrations...
2017: Enzyme Research
https://www.readbyqxmd.com/read/28416882/chemical-composition-antiproliferative-and-antioxidant-activity-of-differently-processed-ganoderma-lucidum-ethanol-extracts
#18
Sonja Veljović, Mile Veljović, Ninoslav Nikićević, Saša Despotović, Siniša Radulović, Miomir Nikšić, Lana Filipović
The content of phenolic compounds (TPC) and glucans, as well as the effectiveness of antiproliferative and antioxidant activity of differently processed Ganoderma lucidum ethanol extracts were determined and compared. The content of glucans (total, α- and β-) strongly depended on the extraction time and particle size, but only interaction of these parameters influenced the TPC. Gallic acid, quercetin, trans-cinnamic acid, kaempferol, hesperetin and naringenin were detected in extracts by HPLC-DAD. The most abundant phenols were hesperetin (1...
April 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28414246/ganoderin-a-a-novel-9-11-secosterol-from-ganoderma-lucidum-spores-oil
#19
Fa-Huan Ge, Ming-Hui Duan, Jing Li, Qing-Long Shi
In this study, four sterols were isolated from the Ganoderma lucidum spores oil obtained via supercritical CO2 extraction. Four chemical constituents were ganoderin A (1), chaxine B (2), ergosterol, (3) and stellasterol (4). All the separated ingredients were characterized using spectral data interpretation and by comparing with reported data. Noticeably, stellasterol and chaxine B were both firstly isolated from Ganoderma lucidum spores oil and ganoderin A was shown to bear an unprecedented skeleton.
April 17, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28402700/characterizing-novel-anti-oncogenic-triterpenoids-from-ganoderma
#20
Xiangmin Li, Yizhen Xie, Burton B Yang
No abstract text is available yet for this article.
April 12, 2017: Cell Cycle
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