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https://www.readbyqxmd.com/read/28802268/ornithine-decarboxylase-mediated-production-of-putrescine-influences-ganoderic-acid-biosynthesis-by-regulating-ros-in-ganoderma-lucidum
#1
Chen-Gao Wu, Jia-Long Tian, Rui Liu, Peng-Fei Cao, Tian-Jun Zhang, Ang Ren, Liang Shi, Ming-Wen Zhao
Putrescine is an important polyamine that participates in a variety of stress responses. Ornithine decarboxylase (ODC) is a key enzyme that catalyzes the biosynthesis of putrescine. A homolog of the gene encoding ODC was cloned from Ganoderma lucidum In the ODC-silenced strains, the transcript levels of the ODC gene and the putrescine content were significantly decreased. The ODC-silenced strains were more sensitive to oxidative stress. The content of ganoderic acid was increased by approximately 43-46% in the ODC-silenced strains...
August 11, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28800421/lanostane-type-triterpenoids-from-the-fruiting-body-of-ganoderma-calidophilum
#2
Sheng-Zhuo Huang, Qing-Yun Ma, Fan-Dong Kong, Zhi-Kai Guo, Cai-Hong Cai, Li-Li Hu, Li-Man Zhou, Qi Wang, Hao-Fu Dai, Wen-Li Mei, You-Xing Zhao
To search for active anti-cancer constituents in the fruiting body of Ganoderma calidophilum, we have successfully isolated four previously undescribed spiro-lactone lanostane triterpenoids (spiroganocalitones A-D), two previously undescribed lanostanoids (ganodecalones A and B) together with twenty-three known ones. The structures of the six previously undescribed compounds were elucidated based on 1D, 2D-NMR, and HRMS analyses. Ganoderone A showed moderate cytotoxic activity against K562, BEL7402, and SGC790 cell lines with IC50 values of 7...
August 8, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28798349/evaluation-on-quality-consistency-of-ganoderma-lucidum-dietary-supplements-collected-in-the-united-states
#3
Ding-Tao Wu, Yong Deng, Ling-Xiao Chen, Jing Zhao, Anton Bzhelyansky, Shao-Ping Li
Ganoderma lucidum is a well-known medicinal mushroom. At present, numerous G. lucidum products have emerged in the form of dietary supplements in the United States due to its various benefits. However, the quality consistency of these products based on their label ingredients has seldom been evaluated due to the lack of a suitable toolkit. In this study, 19 batches of products of G. lucidum (Red Reishi, Reishi), herbal/mushroom supplements purchased in the United States, were evaluated based on their bioactive components including triterpenes and polysaccharides by using chromatographic methods and saccharide mapping...
August 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28762089/secondary-metabolites-from-higher-fungi
#4
He-Ping Chen, Ji-Kai Liu
Secondary metabolites of higher fungi (mushrooms) are an underexplored resource compared to plant-derived secondary metabolites. An increasing interest in mushroom natural products has been noted in recent years. This chapter gives a comprehensive overview of the secondary metabolites from higher fungi, with 765 references highlighting the isolation, structure elucidation, biological activities, chemical syntheses, and biosynthesis of pigments, nitrogen-containing compounds, and terpenoids from mushrooms. Mushroom toxins are also included in each section...
2017: Progress in the Chemistry of Organic Natural Products
https://www.readbyqxmd.com/read/28761785/taxonomic-evaluation-of-selected-ganoderma-species-and-database-sequence-validation
#5
Suldbold Jargalmaa, John A Eimes, Myung Soo Park, Jae Young Park, Seung-Yoon Oh, Young Woon Lim
Species in the genus Ganoderma include several ecologically important and pathogenic fungal species whose medicinal and economic value is substantial. Due to the highly similar morphological features within the Ganoderma, identification of species has relied heavily on DNA sequencing using BLAST searches, which are only reliable if the GenBank submissions are accurately labeled. In this study, we examined 113 specimens collected from 1969 to 2016 from various regions in Korea using morphological features and multigene analysis (internal transcribed spacer, translation elongation factor 1-α, and the second largest subunit of RNA polymerase II)...
2017: PeerJ
https://www.readbyqxmd.com/read/28761429/neuroprotective-effects-of-ganoderma-lucidum-polysaccharides-against-oxidative-stress-induced-neuronal-apoptosis
#6
Xin-Zhi Sun, Ying Liao, Wei Li, Li-Mei Guo
Ganoderma lucidum polysaccharides have protective effects against apoptosis in neurons exposed to ischemia/reperfusion injury, but the mechanisms are unclear. The goal of this study was to investigate the underlying mechanisms of the effects of ganoderma lucidum polysaccharides against oxidative stress-induced neuronal apoptosis. Hydrogen peroxide (H2O2) was used to induce apoptosis in cultured cerebellar granule cells. In these cells, ganoderma lucidum polysaccharides remarkably suppressed H2O2-induced apoptosis, decreased expression of caspase-3, Bax and Bim and increased that of Bcl-2...
June 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28760544/the-potential-of-ganoderma-lucidum-extracts-as-bioactive-ingredients-in-topical-formulations-beyond-its-nutritional-benefits
#7
Oludemi Taofiq, Sandrina A Heleno, Ricardo C Calhelha, Maria José Alves, Lillian Barros, Ana M González-Paramás, Maria F Barreiro, Isabel C F R Ferreira
Ganoderma lucidum was characterized in terms of nutritional value and chemical composition. Thereafter, ethanolic Soxhlet extracts were evaluated for antioxidant, anti-inflammatory, antityrosinase, antimicrobial and cytotoxic effects, and further characterized in terms of phenolic acids, polysaccharides and triterpenoids. Finally, the obtained extracts were tested as cosmeceutical ingredients. G. lucidum proved to be a source of macronutrients and important bioactive compounds such as terpenoids, specially triterpenoids, and polysaccharides...
July 29, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28758107/ganoderma-spp-a-promising-adjuvant-treatment-for-breast-cancer
#8
Ivette J Suárez-Arroyo, Yaliz Loperena-Alvarez, Raysa Rosario-Acevedo, Michelle M Martínez-Montemayor
For the past several decades, cancer patients in the U.S. have chosen the use of natural products as an alternative or complimentary medicine approach to treat or improve their quality of life via reduction or prevention of the side effects during or after cancer treatment. The genus Ganoderma includes about 80 species of mushrooms, of which several have been used for centuries in traditional Asian medicine for their medicinal properties, including anticancer and immunoregulatory effects. Numerous bioactive compounds seem to be responsible for their healing effects...
March 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28736147/novel-multifunctional-plant-growth-promoting-bacteria-in-co-compost-of-palm-oil-industry-waste
#9
Clament Fui Seung Chin, Yoshihide Furuya, Mohd Huzairi Mohd Zainudin, Norhayati Ramli, Mohd Ali Hassan, Yukihiro Tashiro, Kenji Sakai
Previously, a unique co-compost produced by composting empty fruit bunch with anaerobic sludge from palm oil mill effluent, which contributed to establishing a zero-emission industry in Malaysia. Little was known about the bacterial functions during the composting process and fertilization capacity of this co-compost. We isolated 100 strains from the co-compost on 7 types of enumeration media and screened 25 strains using in vitro tests for 12 traits, grouping them according to three functions: plant growth promoting (fixation of nitrogen; solubilization of phosphorus, potassium, and silicate; production of 3-indoleacetic acid, ammonia, and siderophore), biocontrolling (production of chitinase and anti-Ganoderma activity), and composting (degradation of lignin, xylan, and cellulose)...
July 20, 2017: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/28730971/apoptosis-and-anti-cancer-drug-discovery-the-power-of-medicinal-fungi-and-plants
#10
Jack Ho Wong, Stephen Cho Wing Sze, Tzi Bun Ng, Randy Chi Fai Cheung, Chit Tam, Kalin Yanbo Zhang, Xiuli Dan, Yau Sang Chan, William Chi Shing Cho, Charlene Cheuk Wing Ng, Mary Miu Yee Waye, Weicheng Liang, Jinfang Zhang, Jie Yang, Xiuyun Ye, Juan Lin, Xiujuan Ye, Hexiang Wang, Fang Liu, David Wai Chan, Hextan Yuen Sheung Ngan, Ou Sha, Guohui Li, Ryan Tse, Tak Fu Tse, Helen Chan
The purpose of this account is to review the compounds capable of eliciting mitochondria-mediated apoptosis in cancer cells produced by medicinal fungi and plants. The medicinal fungi discussed encompass Cordyceps, Ganoderma species, Coriolus versicolor and Hypsizygus marmoreus. The medicinal plants discussed comprise Astragalus complanatus , Dendrobium spp,Dioscorea spp, Glycyrrhiza spp, Panax notoginseng, Panax ginseng, and Momordica charantia. These compounds have the potential of development into anticancer drugs...
July 20, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28720793/genome-wide-identification-and-characterization-of-natural-antisense-transcripts-by-strand-specific-rna-sequencing-in-ganoderma-lucidum
#11
Junjie Shao, Haimei Chen, Dan Yang, Mei Jiang, Hui Zhang, Bin Wu, Jianqin Li, Lichai Yuan, Chang Liu
Ganoderma lucidum is a white-rot fungus best-known for its medicinal and ligninolytic activities. To discover the underlying genes responsible for these activities, we identified and characterized the natural antisense transcripts (NATs) using strand-specific (ss) RNA-seq data obtained from the mycelia, primordia and fruiting bodies. NATs were identified using a custom pipeline and then subjected to functional enrichment and differential expression analyses. A total of 1613 cis- and 244 trans- sense and antisense transcripts were identified...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28709639/ganoderma-triterpenes-retard-renal-cyst-development-by-downregulating-ras-mapk-signaling-and-promoting-cell-differentiation
#12
Limin Su, Liying Liu, Yingli Jia, Lei Lei, Jiangfeng Liu, Shuai Zhu, Hong Zhou, Ruoyun Chen, Hua Ann Jenny Lu, Baoxue Yang
Autosomal dominant polycystic kidney disease (ADPKD) is a common monogenetic disease characterized by the progressive development of renal cysts with further need for effective therapy. Here our aim was to investigate the effect of Ganoderma triterpenes (GT) on the development of kidney cysts. Importantly, GT attenuated cyst development in two mouse models of ADPKD with phenotypes of severe cystic kidney disease. Assays for tubulogenesis showed that GT promoted epithelial tubule formation in MDCK cells, suggesting a possible effect on epithelial cell differentiation...
July 11, 2017: Kidney International
https://www.readbyqxmd.com/read/28702429/wild-mushrooms-a-potential-source-of-nutritional-and-antioxidant-attributes-with-acceptable-toxicity
#13
Sumaira Sharif, Muhammad Shahid, Muhammad Mushtaq, Sumia Akram, Ayoub Rashid
This paper describes in detail proximate composition, nutritional profile, phytochemical constituents, antioxidant activities, antimicrobial potential, and antihemolytic activity (towards human erythrocytes) of various fractions of wild Ganoderma lucidum. Proximate analysis established that wild G. lucidum comprises about 87.02±5.45% of moisture, and the remaining part is a rich source of proteins (8.59±0.37%), crude fiber (54.21±1.2%), and carbohydrate (35.16%) with smaller fat content (3.33 %). Similarly, phytochemical screening revealed the presence of flavonoids (217...
June 2017: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/28695905/corrigendum-ganoderma-lucidum-reduces-obesity-in-mice-by-modulating-the-composition-of-the-gut-microbiota
#14
Chih-Jung Chang, Chuan-Sheng Lin, Chia-Chen Lu, Jan Martel, Yun-Fei Ko, David M Ojcius, Shun-Fu Tseng, Tsung-Ru Wu, Yi-Yuan Margaret Chen, John D Young, Hsin-Chih Lai
This corrects the article DOI: 10.1038/ncomms8489.
July 11, 2017: Nature Communications
https://www.readbyqxmd.com/read/28695802/effect-of-ganoderma-lucidum-preparation-on-the-behavior-biochemistry-and-autoimmune-parameters-of-mouse-models-of-app-ps1-double-transgenic-alzheimer-s-disease
#15
Chuan Qin, Shanqiu Wu, Baosheng Chen, Xiaoxian Wu, Kunyao Qu, Junmin Liu, Guifang Zhang, Yanfeng Xu, Shunli Shu, Lihua Sun, Yanhong Li, Hua Zhu, Lan Huang, Chunmei Ma, Yuhuan Xu, Yunlin Han, Yaozeng Lu
Objective To evaluate the efficacy of Ganoderma lucidum preparation on the behaviors,biochemistry,and autoimmunity parameters of mouse models of APP/PS-1 double transgenic Alzheimer's disease(AD).Methods A total of 44 4-month-old APP/PS-1 double transgenic AD mice were randomly divided into AD model group,Aricept group,Ganoderma lucidum middle-dose(LZ-M)group,and Ganoderma lucidum high-dose(LZ-H)group,with 11 mice in each group.In addition,10 4-month-old C57BL/6 mice were used as the control group.Water maze test was conducted to observe the behavior changes,and the protein expressions in brain tissues were detected by Western blot analysis...
June 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/28681206/protective-effect-of-ganoderma-lucidum-polysaccharide-against-carbon-tetrachloride-induced-hepatic-damage-in-precision-cut-carp-liver-slices
#16
Yingjuan Liu, Chunyun Zhang, Jinliang Du, Rui Jia, Liping Cao, Galina Jeney, Hiroki Teraoka, Pao Xu, Guojun Yin
The aim of the present study was to investigate the protective effects of Ganoderma lucidum polysaccharide (GLPS) against carbon tetrachloride (CCl4)-induced hepatotoxicity in vitro in common carp. Precision-cut liver slices (PCLSs), which closely resemble the organ from which they are derived, were employed as an in vitro model system. GLPS (0.1, 0.3, and 0.6 mg/ml) was added to PCLS culture system before the exposure to 12 mM CCl4. The supernatants and slices were collected to detect molecular and biochemical responses to CCl4 and PCLS treatments...
July 5, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/28661219/feeding-of-the-water-extract-from-ganoderma-lingzhi-to-rats-modulates-secondary-bile-acids-intestinal-microflora-mucins-and-propionate-important-to-colon-cancer
#17
Yongshou Yang, Dwi Eva Nirmagustina, Thanutchaporn Kumrungsee, Yukako Okazaki, Hiroyuki Tomotake, Norihisa Kato
Consumption of reishi mushroom has been reported to prevent colon carcinogenesis in rodents, although the underlying mechanisms remain unclear. To investigate this effect, rats were fed a high-fat diet supplemented with 5% water extract from either the reishi mushroom (Ganoderma lingzhi) (WGL) or the auto-digested reishi G. lingzhi (AWGL) for three weeks. Both extracts markedly reduced fecal secondary bile acids, such as lithocholic acid and deoxycholic acid (colon carcinogens). These extracts reduced the numbers of Clostridium coccoides and Clostridium leptum (secondary bile acids-producing bacteria) in a per g of cecal digesta...
September 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28657576/nortriterpenoids-from-the-fruiting-bodies-of-the-mushroom-ganoderma-resinaceum
#18
Xian-Qiang Chen, Ling-Xiao Chen, Jing Zhao, Yu-Ping Tang, Shao-Ping Li
Ganoderma resinaceum is usually used as ethnomedicine for immune-regulation, hyperglycemia, and liver disease. To date, only a few chemical constituents have been reported from G. resinaceum. In this study, fifteen nortriterpenoids including six new nortriterpenoids (1-6) and nine known analogs (7-15), were separated and purified from the fruiting bodies of G. resinaceum. New compounds were identified as lucidone I (1), lucidone J (2), lucidone K (3), lucidone I (4), ganosineniol B (5), and ganosineniol C (6), based on analysis of extensive spectroscopic data (high resolution mass spectrometry (HRMS), nuclear magnetic resonance (NMR), infrared (IR), and ultraviolet (UV))...
June 28, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28653896/ganoderma-lucidum-targeting-lung-cancer-signaling-a-review
#19
REVIEW
Balraj Singh Gill, Navgeet, Sanjeev Kumar
Lung cancer causes huge mortality to population, and pharmaceutical companies require new drugs as an alternative either synthetic or natural targeting lung cancer. The conventional therapies cause side effects, and therefore, natural products are used as a therapeutic candidate in lung cancer. Chemical diversity among natural products highlights the impact of evolution and survival of fittest. One such neglected natural product is Ganoderma lucidum used for promoting health and longevity for a longer time...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28618650/anti-amnesic-effects-of-ganoderma-species-a-possible-cholinergic-and-antioxidant-mechanism
#20
Ravneet Kaur, Varinder Singh, Richa Shri
Mushrooms are valued for their nutritional as well as medicinal properties. Ganoderma species are used traditionally to treat neurological disorders but scientific evidence for this is insufficient. The present study was designed to systematically evaluate the anti-amnesic effect of selected Ganoderma species i.e. G. mediosinense and G. ramosissimum. Extracts of selected mushroom species were evaluated for their antioxidant activity and acetylcholinesterase (AChE) inhibition using in-vitro assays (DPPH and Ellman tests respectively)...
August 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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