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https://www.readbyqxmd.com/read/29333391/analysis-of-antioxidant-and-anti-inflammatory-activities-of-solvent-fractions-from-rhynchosia-nulubilis-cultivated-with-ganoderma-lucidum-mycelium
#1
Mihye Park, Meera Kim
In this study, the crude ethanol Rhynchosia nulubilis cultivated with Ganoderma lucidum mycelium (RNGM) extract was solvent fractionated with organic solvents such as n-hexane, chloroform, ethyl acetate, and water. The anticancer activities, anti-inflammatory activity total polyphenols, total flavonoids, isoflavones, and β-glucan of the solvent fractions of RNGM were studied. The ethyl acetate fraction showed the highest 2,2-diphenyl-1-picrylhydrazyl scavenging activity of 76.60% at 800 μg/mL. The ethyl acetate fraction also showed higher antioxidant activity in 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) and ferric reducing ability of plasma assays compared to the other fractions...
December 2017: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/29329646/effects-of-gardenia-jasminoides-extracts-on-cognition-and-innate-immune-response-in-an-adult-drosophila-model-of-alzheimer-s-disease
#2
Wei-Wei Ma, Ye Tao, Yan-Ying Wang, I-Feng Peng
Herbal extracts have been extensively used worldwide for their application on memory improvement, especially among aged and memory-deficit populations. In the present study, the memory loss induced by human Abeta protein over-expression in fruitfly Alzheimer's disease (AD) model was rescued by multiple extracts from Gardenia jasminoides. Three extracts that rich with gardenia yellow, geniposide, and gardenoside components showed distinct rescue effect on memory loss. Further investigation on adding gardenoside into a formula of Ganoderma lucidum, Panax notoginseng and Panax ginseng (GPP) also support its therapeutic effects on memory improvement...
December 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29321636/tyrosinase-based-tlc-autography-for-anti-melanogenic-drug-screening
#3
Kai-Di Hsu, Yu-Hin Chan, Hong-Jhang Chen, Shi-Ping Lin, Kuan-Chen Cheng
Tyrosinase-based TLC (thin layer chromatography) was developed for screening of anti-melanogenic drugs. In particular, this technique enables researchers to identify melanogenic inhibitor(s) in tested mixtures with the naked eye. In comparison with traditional colorimetric screening assays for tyrosinase inhibitor(s), not only is tyrosinase-based TLC a more cost-effective option (nearly one-tenth the enzyme cost of colorimetric methods) but also is a more sensitive detection approach for kojic acid (KA), a standard anti-melanogenic drug...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29311571/assessment-of-polysaccharides-from-mycelia-of-genus-ganoderma-by-mid-infrared-and-near-infrared-spectroscopy
#4
Yuhan Ma, Huaqi He, Jingzhu Wu, Chunyang Wang, Kuanglin Chao, Qing Huang
Ganoderma lingzhi (G. lingzhi), G. sinense, G. applanatum, etc. belongs to the Ganoderma genus of polypore mushrooms which contain rich polysaccharides valuable for nutrition and positive medicinal effects. In order to evaluate polysaccharide content in Ganoderma mycelia obtained in the fermentation process quickly and accurately, in this work we employed infrared spectroscopy to examine different Ganoderma stains of samples from diversified sources. Through mid-infrared (mid-IR) spectroscopy, we could identify the most relevant spectral bands required for polysaccharide evaluation, and through near-infrared (NIR) spectroscopy, we could establish the quantification model for making satisfactory prediction of polysaccharide ingredient content...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29305912/new-natural-inhibitors-of-hexokinase-2-hk2-steroids-from-ganoderma-sinense
#5
Fengyan Bao, Kaiyin Yang, Canrong Wu, Suyu Gao, Penghe Wang, Lixia Chen, Hua Li
Hexokinase 2 (HK2), a rate-limiting enzyme in the first step of glycolysis pathway, expresses at high level in cancer cells compared with normal cells. HK2 provides a new target for cancer therapy due to its pivotal role in tumor tumourigenic and metastatic process. The structure-based virtual ligand screening in a small in-house database of natural products predicted that a new steroid, (22E,24R)-6β-methoxyergosta-7,9(11),22-triene-3β,5α-diol (2) from Ganoderma sinense has high binding affinity to HK2 with significant calculated binding free energy...
January 3, 2018: Fitoterapia
https://www.readbyqxmd.com/read/29305696/14-3-3-proteins-are-involved-in-growth-hyphal-branching-ganoderic-acid-biosynthesis-and-response-to-abiotic-stress-in-ganoderma-lucidum
#6
Tian-Jun Zhang, Liang Shi, Dong-Dong Chen, Rui Liu, Deng-Ke Shi, Chen-Gao Wu, Ze-Hua Sun, Ang Ren, Ming-Wen Zhao
Ganoderma lucidum, which contains many pharmacologically active compounds, is regarded as a traditional medicinal fungus. Nevertheless, the scarcity of basic research limits the commercial value and utilization of G. lucidum. As a class of highly conserved, phosphopeptide-binding proteins present in all eukaryotes, 14-3-3 proteins play vital roles in controlling multiple physiological processes, including signal transduction, primary metabolism, and stress responses. However, knowledge of the roles of 14-3-3 proteins in Basidiomycetes is sparse...
January 5, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29297329/potential-of-selected-fungal-species-to-degrade-wheat-straw-the-most-abundant-plant-raw-material-in-europe
#7
Jasmina Ćilerdžić, Milica Galić, Jelena Vukojević, Ilija Brčeski, Mirjana Stajić
BACKGROUND: Structural component of plant biomass, lignocellulose, is the most abundant renewable resource in nature. Lignin is the most recalcitrant natural aromatic polymer and its degradation presents great challenge. Nowadays, the special attention is given to biological delignification, the process where white-rot fungi take the crucial place owing to strong ligninolytic enzyme system. However, fungal species, even strains, differ in potential to produce high active ligninolytic enzymes and consequently to delignify plant biomass...
December 28, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/29291148/effects-of-wheat-straw-solid-contents-in-fermentation-media-on-utilization-of-soluble-insoluble-nutrient-fungal-growth-and-laccase-production
#8
Antriksh Gupta, Asim Kumar Jana
The objective of the work was to study the effect of agri-residue solid contents (2-20% w v-1) in fermentation medium on fungal growth, soluble and insoluble nutrient consumption and laccase production. Fungal strain Ganoderma lucidium and wheat straw substrate was screened for maximum laccase production. At low solid content submerged fermentation (SmF), fungus utilized mainly soluble nutrient and was unable to access the insoluble nutrient in media due to lack of contact with solid. At high solid content solid-state fermentation (SF), fungi grew on solid surface with dense and thin hyphae, utilized mainly insoluble nutrient...
January 2018: 3 Biotech
https://www.readbyqxmd.com/read/29285139/ganoderma-lucidum-polysaccharide-enhances-radiosensitivity-of-hepatocellular-carcinoma-cell-line-hepg2-through-akt-signaling-pathway
#9
Yang Yu, Liqi Qian, Nan Du, Yuxiao Liu, Xiao Zhao, Xin Zhang
Ganoderma lucidum polysaccharide (GLP) is a well-known traditional Chinese medicine, known for its anti-cancer and immunomodulatory properties. The present study aims to investigate whether GLP has a therapeutic effect on hepatocellular carcinoma (HCC) cells exposed to radiation. Immunofluorescence was used to detect the nuclei, the protein expression was measured by western blot analysis and flow cytometry was used to detect the rate of cell apoptosis. GLP treatment was demonstrated to enhance radiation-induced growth inhibition and apoptotic death of HCC cells...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29281878/synthesis-of-hexaconazole-zinc-aluminium-layered-double-hydroxide-nanocomposite-fungicide-nanodelivery-system-for-controlling-ganoderma-disease-in-oil-palm
#10
Isshadiba Mustafa, Mohd Zobir Hussein, Bullo Saifullah, Abu Seman Idris, Nur Hailini Zainol Hilmi, Sharida Fakurazi
Fungicide, namely hexaconazole was successfully intercalated into the intergalleries of zinc/aluminium-layered double hydroxide (ZALDH) using ion exchange method. Due to the intercalation of hexaconazole, the basal spacing of the ZALDH was increased from 8.7 Å in ZALDH to 29.45 Ǻ in hexaconazole-intercalated ZALDH (HZALDH). The intercalation of hexaconazole into the interlayer of the nanocomposite was confirmed using the Fourier-transform infrared (FTIR) study. This supramolecular chemistry intercalation process enhanced the thermal stability of the hexaconazole moiety...
December 28, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29248453/reishi-mushroom-ganoderma-lucidum-modulates-iga-production-and-alpha-defensin-expression-in-the-rat-small-intestine
#11
Atsuhito Kubota, Masaki Kobayashi, Sota Sarashina, Reiko Takeno, Keisuke Okamoto, Katsuya Narumi, Ayako Furugen, Yuji Suzuki, Natsuko Takahashi, Ken Iseki
ETHNOPHARMACOLOGICAL RELEVANCE: Immunoglobulin A (IgA) secretion and alpha-defensins play a role in the innate immune system to protect against infection. Ganoderma lucidum (W.Curt.:Fr.) P. Karst. (Reishi) is a well-known mushroom in traditional Chinese medicine. This study aimed to determine the effects of Reishi on IgA secretion from Peyer's patch (PP) cells and alpha-defensin-5 (RD-5) and RD-6 expression in the rat small intestine. MATERIALS AND METHODS: The rats received an oral injection of 0...
December 14, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29240252/ganoderma-microsporum-immunomodulatory-protein-induces-apoptosis-and-potentiates-mitomycin-c-induced-apoptosis-in-urinary-bladder-urothelial-carcinoma-cells
#12
Sheng-Yuan Huang, Chih-Cheng Chien, Ruey-Shyang Hseu, Victoria Ying Jen Huang, Shang Ying Chiang, Chi-Jung Huang, Shao-Kuan Chen, Ru-Yin Tsai, Hsi-Ting Lin, Yu-Che Cheng
Current chemotherapy and immunotherapy treatments followed by transurethral resection for urinary bladder urothelial carcinoma (UC) usually suffers from poor prognosis and high recurrence rate. Design and modification of current formulation with the novel adjuvants is needed. A recombinant protein derived from Ganoderma microsporum named as Ganoderma microsporum immunomodulatory protein (GMIP) were used to treat UC cells. We found GMIP elicits a dose-dependent and time-dependent anti-UC cell proliferation effect, with a half-maximal inhibition concentration (IC50 ) comparable to mitomycin C (MMC), a commonly used chemotherapy agent...
December 14, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29233661/hypoglycemic-mechanism-of-a-novel-proteoglycan-extracted-from-ganoderma-lucidum-in-hepatocytes
#13
Zhou Yang, Congheng Chen, Juan Zhao, Weijie Xu, Yanming He, Hongjie Yang, Ping Zhou
Protein tyrosine phosphatase 1 B (PTP1B) is one of main causes involved in type 2 diabetes, it dephosphorylates insulin receptor substrate (IRS) and dysregulates insulin signaling pathway, thus inducing insulin resistance. Our previous work first reported that FYGL, a neutral hyperbranched proteoglycan ingredient extracted from Ganoderma lucidum, has hypoglycemic activity in vivo and inhibitory potency on PTP1B in vitro, but the underlying mechanism was still unclear. In this study, we sought to investigate effects of FYGL on insulin signaling pathway involved with PTP1B as the targeting point in hepatocytes...
December 9, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29221173/farnesyl-phenolic-enantiomers-as-natural-mth1-inhibitors-from-ganoderma-sinense
#14
Ya Gao, Lihan Zhu, Jing Guo, Ting Yuan, Liqing Wang, Hua Li, Lixia Chen
Cancer cells are more addictive to MTH1 than normal cells because of their dysfunctional redox regulations. MTH1 plays an important role to maintain tumor cell survival, while it is not indispensable for the growth of normal cells. Farnesyl phenols having a coumaroyl substitution are rather uncommon in nature. Eight farnesyl phenolic compounds with such substituent moiety (1-8), including six new ones, ganosinensols E-J (1-6) were isolated from the 95% EtOH extract of the fruiting bodies of Ganoderma sinense...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29215673/extraction-of-triterpenoids-and-phenolic-compounds-from-ganoderma-lucidum-optimization-study-using-the-response-surface-methodology
#15
Taofiq Oludemi, Lillian Barros, M A Prieto, Sandrina A Heleno, Maria F Barreiro, Isabel C F R Ferreira
The extraction of triterpenoids and phenolic compounds from Ganoderma lucidum was optimized by using the response surface methodology (RSM), using heat and ultrasound assisted extraction techniques (HAE and UAE). The obtained results were compared with that of the standard Soxhlet procedure. RSM was applied using a circumscribed central composite design with three variables (time, ethanol content, and temperature or ultrasonic power) and five levels. The conditions that maximize the responses (extraction yield, triterpenoids and total phenolics) were: 78...
December 7, 2017: Food & Function
https://www.readbyqxmd.com/read/29215104/a-novel-ptp1b-inhibitor-extracted-from-ganoderma-lucidum-ameliorates-insulin-resistance-by-regulating-irs1-glut4-cascades-in-the-insulin-signaling-pathway
#16
Zhou Yang, Fan Wu, Yanming He, Qiang Zhang, Yuan Zhang, Guangrong Zhou, Hongjie Yang, Ping Zhou
Insulin resistance caused by the overexpression of protein tyrosine phosphatase 1 B (PTP1B) as well as the dephosphorylation of its target is one of the main causes of type 2 diabetes (T2D). A newly discovered proteoglycan, Fudan-Yueyang Ganoderma lucidum (FYGL) extracted from Ganoderma lucidum, was first reported to be capable of competitively inhibiting PTP1B activity in vitro in our previous work. In the present study, we sought to reveal the mechanism of PTP1B inhibition by FYGL at the animal and cellular levels...
December 7, 2017: Food & Function
https://www.readbyqxmd.com/read/29204990/apoptosis-induction-of-colorectal-cancer-cells-htl-9-in-vitro-by-the-transformed-products-of-soybean-isoflavones-by-ganoderma-lucidum
#17
Mei-Lin Cui, Huan-Yi Yang, Guo-Qing He
Soybean isoflavones have been one of the potential preventive candidates for antitumor research in recent years. In this paper, we first studied the transformation of soybean isoflavones with the homogenized slurry of Ganoderma lucidum. The resultant transformed products (TSI) contained (703.21±4.35) mg/g of genistein, with transformed rates of 96.63% and 87.82% of daidzein and genistein, respectively, and TSI also could enrich the bioactive metabolites of G. lucidum. The antitumor effects of TSI on human colorectal cancer cell line HTL-9, human breast cancer cell line MCF-7, and human immortalized gastric epithelial cell line GES-1 were also studied...
2017: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/29201838/ganoderma-lucidum-protects-rat-brain-tissue-against-trauma-induced-oxidative-stress
#18
Özevren Hüseyin, İrtegün Sevgi, Deveci Engin, Aşır Fırat, Pektanç Gülsüm, Deveci Şenay
Objective: Traumatic brain injury causes tissue damage, breakdown of cerebral blood flow and metabolic regulation. This study aims to investigate the protective influence of antioxidant Ganoderma lucidum (G. lucidum) polysaccharides (GLPs) on brain injury in brain-traumatized rats. Methods: Sprague-Dawley conducted a head-traumatized method on rats by dropping off 300 g weight from 1 m height. Groups were categorized as control, G. lucidum, trauma, trauma+ G. lucidum (20 mL/kg per day via gastric gavage)...
October 2017: Korean Journal of Neurotrauma
https://www.readbyqxmd.com/read/29199581/molecular-dynamics-and-virtual-screening-analysis-of-lanosterol-derivatives-from-ganoderma-medicinal-mushrooms-agaricomycetes-as-selective-ligands-of-human-androgen-receptor
#19
Abraham M Vidal-Limon, Oscar Daniel Luna-Martinez, Fausto Rojas-Durán, Thuluz Meza-Menchaca, Maria Elena Hernández-Aguilar, Angel Trigos, Jorge Suárez-Medellín
Male sex hormones such as testosterone and dihydrotestosterone play important roles in several physiological and pathological processes. The biological activities of the aforementioned metabolites are mediated by the multidomain androgen receptor (AR), which is therefore a well-studied drug target. Ganoderma mushroom lanostanoid extracts have previously been shown to exert antiandrogenic activity; therefore, this work aims to identify which lanostane derivatives might act as selective ligands for AR. Because protein flexibility is of paramount importance for ligand binding, different conformations of AR were sampled to account for binding modes within a ligand binding site, then subjected to virtual screening against a metabolite library...
2017: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/29199580/what-is-ganoderma-lucidum-in-the-molecular-era
#20
Viktor Papp, Bálint Dima, Solomon P Wasser
The scientific name Ganoderma lucidum has long been used in the global medicinal mushroom market, and many publications have proven its pharmacological properties and chemical components. Although several Ganoderma species have been described worldwide as having morphology considerably similar to that of G. lucidum s. str., this binomial is still the most frequently used in pharmacological studies. However, the use of particularly divergent nomenclature has caused major difficulties in the evaluation of the results of pharmacological studies...
2017: International Journal of Medicinal Mushrooms
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