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Transactional analysis

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https://www.readbyqxmd.com/read/28646512/wmj-8-b-a-novel-hydroxamate-derivative-induces-mda-mb-231-breast-cancer-cell-death-via-shp-1-stat3-survivin-cascade
#1
Yu-Fan Chuang, Shiu-Wen Huang, Ya-Fen Hsu, Meng-Chieh Yu, George Ou, Wei-Jan Huang, Ming-Jen Hsu
BACKGROUND AND PURPOSE: Histone deacetylase (HDAC) inhibitors with broad-spectrum anti-tumor properties has been described and attracted lots of attention in the field of drug discovery. However, the underlying anti-tumor mechanisms of HDAC inhibitors remain incompletely understood. In this study, we aimed to characterize the underlying mechanisms of a novel hydroxamate-based HDAC inhibitor, WMJ-8-B, in inducing MDA-MB-231 breast cancer cell death. EXPERIMENTAL APPROACH: WMJ-8-B's effects on cell viability, cell cycle distribution, apoptosis, as well as signaling molecules modification and activation were analyzed by MTT assay, flowcytometric analysis, immunoblotting, reporter assay, ChIP analysis and siRNA strategy...
June 23, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28619027/-health-is-my-capital-a-qualitative-study-of-access-to-healthcare-by-chinese-migrants-in-singapore
#2
Wai Jia Tam, Wei Leong Goh, Jeffrey Chua, Helena Legido-Quigley
BACKGROUND: Since the 1970s, Singapore has turned into one of the major receiving countries of foreign workers in Southeast Asia. Over the years, challenges surrounding access to healthcare by Chinese migrant workers have surfaced globally. This study aims to explore the experiences of Chinese migrants accessing primary and secondary/tertiary healthcare in Singapore, and the opportunities for overcoming these barriers. METHODS: We conducted 25 in-depth interviews of 20 Chinese migrants and five staff from HealthServe, a non-governmental organization serving Chinese migrants in Singapore from October 2015 to January 2016...
June 15, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/28618493/simple-wealth-distribution-model-causing-inequality-induced-crisis-without-external-shocks
#3
Henri Benisty
We address the issue of the dynamics of wealth accumulation and economic crisis triggered by extreme inequality, attempting to stick to most possibly intrinsic assumptions. Our general framework is that of pure or modified multiplicative processes, basically geometric Brownian motions. In contrast with the usual approach of injecting into such stochastic agent models either specific, idiosyncratic internal nonlinear interaction patterns or macroscopic disruptive features, we propose a dynamic inequality model where the attainment of a sizable fraction of the total wealth by very few agents induces a crisis regime with strong intermittency, the explicit coupling between the richest and the rest being a mere normalization mechanism, hence with minimal extrinsic assumptions...
May 2017: Physical Review. E
https://www.readbyqxmd.com/read/28616251/physical-micro-environment-interventions-for-healthier-eating-in-the-workplace-protocol-for-a-stepped-wedge-randomised-controlled-pilot-trial
#4
Milica Vasiljevic, Emma Cartwright, Rachel Pechey, Gareth J Hollands, Dominique-Laurent Couturier, Susan A Jebb, Theresa M Marteau
BACKGROUND: An estimated one third of energy is consumed in the workplace. The workplace is therefore an important context in which to reduce energy consumption to tackle the high rates of overweight and obesity in the general population. Altering environmental cues for food selection and consumption-physical micro-environment or 'choice architecture' interventions-has the potential to reduce energy intake. The first aim of this pilot trial is to estimate the potential impact upon energy purchased of three such environmental cues (size of portions, packages and tableware; availability of healthier vs...
2017: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/28560335/global-disparity-in-the-supply-of-commercial-weather-and-climate-information-services
#5
Lucien Georgeson, Mark Maslin, Martyn Poessinouw
Information about weather and climate is vital for many areas of decision-making, particularly under conditions of increasing vulnerability and uncertainty related to climate change. We have quantified the global commercial supply of weather and climate information services. Although government data are sometimes freely available, the interpretation and analysis of those data, alongside additional data collection, are required to formulate responses to specific challenges in areas such as health, agriculture, and the built environment...
May 2017: Science Advances
https://www.readbyqxmd.com/read/28534276/disentangling-child-specific-and-family-wide-processes-underlying-negative-mother-child-transactions
#6
André Plamondon, Dillon T Browne, Sheri Madigan, Jennifer M Jenkins
The current study examines the transactional processes between maternal negativity and child disruptive behavior during early childhood, using a sibling comparison design. This design allows for a more sophisticated test of the behavioral training hypothesis than is possible when only one child per family is included in the analysis as it excludes two confounders (passive gene-environment correlation and family-wide environmental influence). Three hundred and ninety-seven families were visited on three occasions when the target child was 1...
May 23, 2017: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/28512634/user-experience-analysis-of-e-tb-manager-a-nationwide-electronic-tuberculosis-recording-and-reporting-system-in-ukraine
#7
Niranjan Konduri, Kelly Sawyer, Nataliya Nizova
Ukraine has successfully implemented e-TB Manager nationwide as its mandatory national tuberculosis registry after first introducing it in 2009. Our objective was to perform an end-of-programme evaluation after formal handover of the registry administration to Ukraine's Centre for Disease Control in 2015. We conducted a nationwide, cross-sectional, anonymous, 18-point user experience survey, and stratified the registry's transaction statistics to demonstrate usability. Contrary to initial implementation experience, older users (aged >50 years), often with limited or no computer proficiency prior to using the registry, had significantly better user experience scores for at least six of the 12 measures compared to younger users (aged 18-29 years)...
April 2017: ERJ Open Research
https://www.readbyqxmd.com/read/28502034/stressful-life-events-during-adolescence-and-risk-for-externalizing-and-internalizing-psychopathology-a-meta-analysis
#8
REVIEW
Jaume March-Llanes, Laia Marqués-Feixa, Laura Mezquita, Lourdes Fañanás, Jorge Moya-Higueras
The main objective of the present research was to analyze the relations between stressful life events and the externalizing and internalizing spectra of psychopathology using meta-analytical procedures. After removing the duplicates, a total of 373 papers were found in a literature search using several bibliographic databases, such as the PsycINFO, Medline, Scopus, and Web of Science. Twenty-seven studies were selected for the meta-analytical analysis after applying different inclusion and exclusion criteria in different phases...
May 13, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28498843/when-bitcoin-encounters-information-in-an-online-forum-using-text-mining-to-analyse-user-opinions-and-predict-value-fluctuation
#9
Young Bin Kim, Jurim Lee, Nuri Park, Jaegul Choo, Jong-Hyun Kim, Chang Hun Kim
Bitcoin is an online currency that is used worldwide to make online payments. It has consequently become an investment vehicle in itself and is traded in a way similar to other open currencies. The ability to predict the price fluctuation of Bitcoin would therefore facilitate future investment and payment decisions. In order to predict the price fluctuation of Bitcoin, we analyse the comments posted in the Bitcoin online forum. Unlike most research on Bitcoin-related online forums, which is limited to simple sentiment analysis and does not pay sufficient attention to note-worthy user comments, our approach involved extracting keywords from Bitcoin-related user comments posted on the online forum with the aim of analytically predicting the price and extent of transaction fluctuation of the currency...
2017: PloS One
https://www.readbyqxmd.com/read/28498292/the-effects-of-conflicts-of-interest-on-practice-patterns-and-complication-rates-in-spine-surgery
#10
Ralph W Cook, Joseph A Weiner, Michael S Schallmo, Danielle S Chun, Kathryn A Barth, Sameer K Singh, Wellington K Hsu
STUDY DESIGN: Retrospective cohort study. OBJECTIVE: We sought to determine whether financial relationships with industry had any impact on operative and/or complication rates of spine surgeons performing fusion surgeries. SUMMARY OF BACKGROUND DATA: Recent actions from Congress and the Institute of Medicine have highlighted the importance of conflicts of interest among physicians. Orthopaedic surgeons and neurosurgeons have been identified as receiving the highest amount of industry payments among all specialties...
May 11, 2017: Spine
https://www.readbyqxmd.com/read/28493481/hospital-and-health-insurance-markets-concentration-and-inpatient-hospital-transaction-prices-in-the-u-s-health-care-market
#11
Seidu Dauda
OBJECTIVE: To examine the effects of hospital and insurer markets concentration on transaction prices for inpatient hospital services. DATA SOURCES: Measures of hospital and insurer markets concentration derived from American Hospital Association and HealthLeaders-InterStudy data are linked to 2005-2008 inpatient administrative data from Truven Health MarketScan Databases. STUDY DESIGN: Uses a reduced-form price equation, controlling for cost and demand shifters and accounting for possible endogeneity of market concentration using instrumental variables (IV) technique...
May 11, 2017: Health Services Research
https://www.readbyqxmd.com/read/28490855/using-transactivity-to-understand-emergence-of-team-learning
#12
Hildert Zoethout, Renate Wesselink, Piety Runhaar, Martin Mulder
Team learning is a recurrent topic in research on effective teamwork. However, research about the fact that team learning processes emerge from conversations and the different forms this emergence can take is limited. The aim of this study is to determine whether the extent to which team members act on each other's reasoning (transactivity) can be used to understand how team learning processes emerge. Research on teacher teams was used as the case study: Video recordings of three different teacher teams were used as primary data, and the data were analyzed using qualitative interaction analysis...
April 2017: Small Group Research
https://www.readbyqxmd.com/read/28484948/enhanced-recognition-of-memorable-pictures-in-ultra-fast-rsvp
#13
Nico Broers, Mary C Potter, Mark R Nieuwenstein
Long-term recognition memory for some pictures is consistently better than for others (Isola, Xiao, Parikh, Torralba, & Oliva, IEEE Transaction on Pattern Analysis and Machine Intelligence (PAMI), 36(7), 1469-1482, 2014). Here, we investigated whether pictures found to be memorable in a long-term memory test are also perceived more easily when presented in ultra-rapid RSVP. Participants viewed 6 pictures they had never seen before that were presented for 13 to 360 ms per picture in a rapid serial visual presentation (RSVP) sequence...
May 8, 2017: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/28479549/patient-summaries-in-context-of-large-scale-ehr-networks-with-fine-granular-access-control-restrictions
#14
Patrick Mangesius, Samrend Saboor, Thomas Schabetsberger
BACKGROUND: Large Scale Electronic Health Record (EHR) systems tend to contain a significant higher amount of patient data compared to traditional local Electronic Medical Record (EMR) silos. This demands the requirement of providing a user context and role specific summary of the patient record. Security and Access Control systems are a crucial part of modern EHR systems controlling legal policies and patient consents. Goal of this paper is to elaborate a concept enhancing an already existing, commonly based on IHE XDS and XACML based, EHR systems with summarization functionalities...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28471761/american-exceptionalism-and-the-american-surgical-association-the-rise-of-surgery-in-the-united-states
#15
Ira Rutkow, Keith D Lillemoe
OBJECTIVE: To explore use of the notion of American exceptionalism by fellows of the American Surgical Association (ASA) (1880 through World War I) and how this proved instrumental in the rise of surgery in the United States. BACKGROUND: American exceptionalism is the belief that the United States is innately different from other nations because of its economic, geographic, political, religious, and social foundations. Although, currently, the concept of American exceptionalism implies superiority, in its original 19th century connotation, the idea referred to the distinctive character of America as a free nation...
May 2, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28466811/arnetmit-r-package-association-rules-based-gene-co-expression-networks-of-mirna-targets
#16
M Özgür Cingiz, G Biricik, B Diri
miRNAs are key regulators that bind to target genes to suppress their gene expression level. The relations between miRNA-target genes enable users to derive co-expressed genes that may be involved in similar biological processes and functions in cells. We hypothesize that target genes of miRNAs are co-expressed, when they are regulated by multiple miRNAs. With the usage of these co-expressed genes, we can theoretically construct co-expression networks (GCNs) related to 152 diseases. In this study, we introduce ARNetMiT that utilize a hash based association rule algorithm in a novel way to infer the GCNs on miRNA-target genes data...
March 31, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28465273/assessment-and-treatment-of-peritumoral-cortical-veins-in-parasagittal-meningiomas-with-application-of-3d-imaging-fusion-model
#17
Tengkun Yin, Jianjun Gu, Yinxing Huang, Liangfeng Wei, Jinxi Gao, Shousen Wang
BACKGROUND: Operation of cortical veins is the keystone of parasagittal meningiomas (PSM) resection. Little is known about pathological changes of the veins and proper treatment. We built three-dimensional (3D) image fusion models by neuronavigation to analyze the features of peritumoral cortical veins for PSM and explore intraoperative treatment options. METHODS: We performed a prospective study of 42 consecutive surgically treated PSM patients who underwent preoperative evaluation of peritumoral cortical veins using a 3D venous-tumor fusion model established by a neuronavigation system...
April 29, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28460754/pig-traders-networks-on-the-kenya-uganda-border-highlight-potential-for-mitigation-of-african-swine-fever-virus-transmission-and-improved-asf-disease-risk-management
#18
Jacqueline Kasiiti Lichoti, Jocelyn Davies, Yiheyis Maru, Philip M Kitala, Samuel M Githigia, Edward Okoth, Salome A Bukachi, Sam Okuthe, Richard P Bishop
We applied social network analysis to pig trader networks on the Kenya-Uganda border. Social network analysis is a recently developed tool, which is useful for understanding value chains and improving disease control policies. We interviewed a sample of 33 traders about their experiences with trade and African swine fever (ASF), analyzed the networks they generated in purchasing pigs and selling pork and their potential contribution to modulating dissemination of the ASF virus (ASFV). The majority of the traders were aware of clinical signs of ASF and the risk of trade transmitting ASFV...
May 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28453527/altered-nucleocytoplasmic-proteome-and-transcriptome-distributions-in-an-in-vitro-model-of-amyotrophic-lateral-sclerosis
#19
Jee-Eun Kim, Yoon Ho Hong, Jin Young Kim, Gye Sun Jeon, Jung Hee Jung, Byung-Nam Yoon, Sung-Yeon Son, Kwang-Woo Lee, Jong-Il Kim, Jung-Joon Sung
Aberrant nucleocytoplasmic localization of proteins has been implicated in many neurodegenerative diseases. Evidence suggests that cytoplasmic mislocalization of nuclear proteins such as transactive response DNA-binding protein 43 (TDP-43) and fused in sarcoma (FUS) may be associated with neurotoxicity in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration. This study investigated the changes in nucleocytoplasmic distributions of the proteome and transcriptome in an in vitro model of ALS...
2017: PloS One
https://www.readbyqxmd.com/read/28448328/hospice-or-community-network-choices-in-end-of-life-care-in-jamaica
#20
Roger Lee Mendoza
AIM: Now considered a subspecialty of medicine and nursing, palliative care is a critical aspect of healthcare at the end of life. National and international healthcare agencies typically attribute its slow or haphazard growth in developing countries to various resource constraints. However, this study provides evidence of the substantial and widening gap between policy advocacy and patient choices in end-of-life care. It does so by establishing the incentives and risks that underlie decision-making by patients and providers against the relative scarcity of palliative care and hospices in these countries...
May 25, 2017: International Journal of Evidence-based Healthcare
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