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https://www.readbyqxmd.com/read/28330421/the-proteinopathy-of-d169g-and-k263e-mutants-at-the-rna-recognition-motif-rrm-domain-of-tar-dna-binding-protein-tdp43-causing-neurological-disorders-a-computational-study
#1
Vishwambhar Vishnu Bhandare, Amutha Ramaswamy
One of the multitasking proteins, transactive response DNA-binding protein 43 (tdp43) plays a key role in RNA regulation and the two pathogenic mutations such as D169G and K263E, located at the RNA Recognition Motif (RRM) of tdp43, are reported to cause neurological disorders such as Amyotrophic Lateral Sclerosis (ALS) and Fronto Temporal Lobar Degeneration (FTLD). As the exploration of the proteinopathy demands both structural and functional characterization of mutants, a comparative analysis on the wild type and mutant tdp43 (D169G and K263E) and their complexes with RNA have been performed using computational approaches...
March 22, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28321162/mortality-associated-with-gastrointestinal-bleeding-in-children-a-retrospective-cohort-study
#2
Thomas M Attard, Mikaela Miller, Chaitanya Pant, Ashwath Kumar, Mike Thomson
AIM: To determine the clinical characteristics of children with gastrointestinal bleeding (GIB) who died during the course of their admission. METHODS: We interrogated the Pediatric Hospital Information System database, including International Classification of Diseases, Current Procedural Terminology and Clinical Transaction Classification coding from 47 pediatric tertiary centers extracting the population of patients (1-21 years of age) admitted (inpatient or observation) with acute, upper or indeterminate GIB (1/2007-9/2015)...
March 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28294094/market-organization-and-animal-genetic-resource-management-a-revealed-preference-analysis-of-sheep-pricing
#3
K Tindano, N Moula, P Leroy, A Traoré, N Antoine-Moussiaux
Farm animal genetic resources are threatened worldwide. Participation in markets, while representing a crucial way out of poverty for many smallholders, affects genetic management choices with associated sustainability concerns. This paper proposes a contextualized study of the interactions between markets and animal genetic resources management, in the case of sheep markets in Ouagadougou, Burkina Faso. It focusses on the organization of marketing chains and the valuation of genetic characteristics by value chain actors...
March 15, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28288356/the-effect-of-prices-on-nutrition-comparing-the-impact-of-product-and-nutrient-specific-taxes
#4
Matthew Harding, Michael Lovenheim
This paper provides an analysis of the role of prices in determining food purchases and nutrition using very detailed transaction-level observations for a large, nationally-representative sample of US consumers over the period 2002-2007. Using product-specific nutritional information, we develop a new method of partitioning the product space into relevant nutritional clusters that define a set of nutritionally-bundled goods, which parsimoniously characterize consumer choice sets. We then estimate a large utility-derived demand system over this joint product-nutrient space that allows us to calculate price and expenditure elasticities...
February 28, 2017: Journal of Health Economics
https://www.readbyqxmd.com/read/28242115/an-economic-inquisition-of-water-quality-trading-programs-with-a-case-study-of-jordan-lake-nc
#5
Marzieh Motallebi, Dana L Hoag, Ali Tasdighi, Mazdak Arabi, Deanna L Osmond
A water quality trading (WQT) program was promulgated in North Carolina to address water quality issues related to nutrients in the highly urbanizing Jordan Lake Watershed. Although WQT programs are appealing in theory, the concept has not proved feasible in several attempts between point and nonpoint polluters in the United States. Many application hurdles that create wedges between success and failure have been evaluated in the literature. Most programs, however, face multiple hurdles; eliminating one may not clear a pathway to success...
May 15, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28225822/a-reconfiguration-of-the-sex-trade-how-social-and-structural-changes-in-eastern-zimbabwe-left-women-involved-in-sex-work-and-transactional-sex-more-vulnerable
#6
Jocelyn Elmes, Morten Skovdal, Kundai Nhongo, Helen Ward, Catherine Campbell, Timothy B Hallett, Constance Nyamukapa, Peter J White, Simon Gregson
Understanding the dynamic nature of sex work is important for explaining the course of HIV epidemics. While health and development interventions targeting sex workers may alter the dynamics of the sex trade in particular localities, little has been done to explore how large-scale social and structural changes, such as economic recessions-outside of the bounds of organizational intervention-may reconfigure social norms and attitudes with regards to sex work. Zimbabwe's economic collapse in 2009, following a period (2000-2009) of economic decline, within a declining HIV epidemic, provides a unique opportunity to study community perceptions of the impact of socio-economic upheaval on the sex trade...
2017: PloS One
https://www.readbyqxmd.com/read/28222806/internalized-homophobia-mental-health-sexual-behaviors-and-outness-of-gay-bisexual-men-from-southwest-china
#7
Wenjian Xu, Lijun Zheng, Yin Xu, Yong Zheng
BACKGROUND: Social attitudes toward male homosexuality in China so far are still not optimistic. Sexual minorities in China have reported high levels of internalized homophobia. METHODS: This Internet-based study examined the associations among internalized homophobia, mental health, sexual behaviors, and outness among 435 gay/bisexual men in Southwest China from 2014 to 2015. Latent profile analysis, confirmatory factor analysis, univariate logistic regression, and separate multivariate logistic regression analyses were conducted...
February 17, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/28167585/prospectus-towards-the-development-of-high-fidelity-models-of-wall-turbulence-at-large-reynolds-number
#8
J C Klewicki, G P Chini, J F Gibson
Recent and on-going advances in mathematical methods and analysis techniques, coupled with the experimental and computational capacity to capture detailed flow structure at increasingly large Reynolds numbers, afford an unprecedented opportunity to develop realistic models of high Reynolds number turbulent wall-flow dynamics. A distinctive attribute of this new generation of models is their grounding in the Navier-Stokes equations. By adhering to this challenging constraint, high-fidelity models ultimately can be developed that not only predict flow properties at high Reynolds numbers, but that possess a mathematical structure that faithfully captures the underlying flow physics...
March 13, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28155031/-i-got-it-off-my-chest-an-examination-of-how-research-participation-improved-the-mental-health-of-women-engaging-in-transactional-sex
#9
Marisa Felsher, Sarah E Wiehe, Jayleen K L Gunn, Alexis M Roth
Ecologic momentary assessment (EMA) is a form of close-ended diary writing. While it has been shown that participating in a study that incorporates EMA improves mental health of participants, no study to date has examined the pathways through which benefits may occur. For 4-weeks, twice-daily EMAs and weekly interviews captured mood, daily activities and HIV risk behavior of 25 women who engage in transactional sex. Qualitative analysis of exit interviews was performed to examine how participation impacted women's mental health...
February 2, 2017: Community Mental Health Journal
https://www.readbyqxmd.com/read/28152754/eleven-year-experience-with-a-web-based-medication-occurrence-mo-reporting-tool-in-a-community-oncology-practice
#10
Tae W Jang, Jim R Schwartz
53 Background: At ASCO 2007, we presented 2 year experience with a web-based Medication Occurrence (MO) reporting tool. We now report the 11 year experience in a single outpatient oncology practice. METHODS: Since December 2003, Texas Oncology (TxO) sites have entered information on Medication Occurrence (MO) reports in an electronic Variance Reporting tool. The pharmacy management team generates reports monthly for the Texas Oncology Quality Oversight Committee and each site Quality Committee for analysis and follow-up action...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28144681/electronic-sentinel-surveillance-of-influenza-like-illness-experience-from-a-pilot-study-in-new-zealand
#11
Mehnaz Adnan, Donald Peterkin, Liza Lopez, Graham Mackereth
BACKGROUND: Electronic reporting of Influenza-like illness (eILI) from primary care was implemented and evaluated in three general medical practices in New Zealand during May to September 2015. OBJECTIVE: To measure the uptake of eILI and to identify the system's strength and limitations. METHODS: Analysis of transactional data from the eILI system; comparative study of influenza-like illness cases reported using manual methods and eILI; questionnaire administered to clinical and operational stakeholders...
February 1, 2017: Applied Clinical Informatics
https://www.readbyqxmd.com/read/28140660/the-sexual-health-of-transgender-men-a-scoping-review
#12
Rob Stephenson, Erin Riley, Erin Rogers, Nicolas Suarez, Nick Metheny, Jonathan Senda, Kate M Saylor, José A Bauermeister
There is a general paucity of research concerning the sexual health of transgender individuals, and most existing research focuses on transgender women. A scoping review concerning the sexual health of transgender men was conducted to identify gaps in the literature and to highlight opportunities for future research and intervention. A comprehensive search of seven databases was conducted. The Joanna Briggs Institute Reviewers' Manual was used as a framework. Some 7,485 articles were initially identified using a search strategy applied to seven online databases: 54 articles were identified as relevant to the research questions and reviewed in detail; of those, 33 were included in the final analysis...
January 31, 2017: Journal of Sex Research
https://www.readbyqxmd.com/read/28125656/trends-of-the-world-input-and-output-network-of-global-trade
#13
Rita María Del Río-Chanona, Jelena Grujić, Henrik Jeldtoft Jensen
The international trade naturally maps onto a complex networks. Theoretical analysis of this network gives valuable insights about the global economic system. Although different economic data sets have been investigated from the network perspective, little attention has been paid to its dynamical behaviour. Here we take the World Input Output Data set, which has values of the annual transactions between 40 different countries of 35 different sectors for the period of 15 years, and infer the time interdependence between countries and sectors...
2017: PloS One
https://www.readbyqxmd.com/read/28124195/the-form-of-causation-in-health-disease-and-intervention-biopsychosocial-dispositionalism-conserved-quantity-transfers-and-dualist-mechanistic-chains
#14
David W Evans, Nicholas Lucas, Roger Kerry
Causation is important when considering: how an organism maintains health; why disease arises in a healthy person; and, how one may intervene to change the course of a disease. This paper explores the form of causative relationships in health, disease and intervention, with particular regard to the pathological and biopsychosocial models. Consistent with the philosophical view of dispositionalism, we believe that objects are the fundamental relata of causation. By accepting the broad scope of the biopsychosocial model, we argue that psychological and social constructs be considered objects...
January 25, 2017: Medicine, Health Care, and Philosophy
https://www.readbyqxmd.com/read/28124161/child-regulative-temperament-as-a-mediator-of-parenting-in-the-development-of-depressive-symptoms-a-longitudinal-study-from-early-childhood-to-preadolescence
#15
Martina Pitzer, Guenter Esser, Martin H Schmidt, Erika Hohm, Tobias Banaschewski, Manfred Laucht
Child temperament as well as parenting behaviors have been linked to adolescent depression. Beyond their main effects, the interplay between these factors is of interest. For example, in an interactive model, a differential susceptibility of temperamental variants to parenting has been suggested. However, so far, the differential susceptibility hypothesis has mostly been studied with a focus on externalizing disorders. On the other hand, parenting may shape the child's temperament and vice versa in a transactional process...
January 25, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28120552/quantification-of-missing-prescriptions-in-commercial-claims-databases-results-of-a-cohort-study
#16
Maria Soledad Cepeda, Daniel Fife, Michel Denarié, Dan Bradford, Stephanie Roy, Yingli Yuan
PURPOSE: This study aims to quantify the magnitude of missed dispensings in commercial claims databases. METHODS: A retrospective cohort study has been used linking PharMetrics, a commercial claims database, to a prescription database (LRx) that captures pharmacy dispensings independently of payment method, including cash transactions. We included adults with dispensings for opioids, diuretics, antiplatelet medications, or anticoagulants. To determine the degree of capture of dispensings, we calculated the number of subjects with the following: (1) same number of dispensings in both databases; (2) at least one dispensing, but not all dispensings, missed in PharMetrics; and (3) all dispensings missing in PharMetrics...
January 25, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28113260/minimum-entropy-rate-simplification-of-stochastic-processes
#17
Gustav Eje Henter, W Bastiaan Kleijn
This document contains supplemental material for the IEEE Transactions on Pattern Analysis and Machine Intelligence article "Minimum Entropy Rate Simplification of Stochastic Processes." The supplement is divided into three appen- dices: the first on MERS for Gaussian processes, and the remaining two on, respectively, the theory and the experimental results of MERS for Markov chains.
February 23, 2016: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://www.readbyqxmd.com/read/28113232/commentary-on-the-integration-of-model-sharing-and-reproducibility-analysis-to-scholarly-publishing-workflow-in-computational-biomechanics
#18
Ahmet Erdemir, Trent M Guess, Jason Halloran, Luca Modenese, Jeffrey A Reinbolt, Darryl G Thelen, Brian R Umberger
OBJECTIVE: The overall goal of this document is to demonstrate that dissemination of models and analyses for assessing the reproducibility of simulation results can be incorporated in the scientific review process in biomechanics. METHODS: As part of a special issue on model sharing and reproducibility in IEEE Transactions on Biomedical Engineering, two manuscripts on computational biomechanics were submitted: A. Rajagopal et al., IEEE Trans. Biomed. Eng., 2016 and A...
August 24, 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28110864/sexual-behavior-among-orphaned-adolescents-in-western-kenya-a-comparison-of-institutional-and-family-based-care-settings
#19
Lonnie Embleton, Joram Nyandat, David Ayuku, Edwin Sang, Allan Kamanda, Samuel Ayaya, Winstone Nyandiko, Peter Gisore, Rachel Vreeman, Lukoye Atwoli, Omar Galarraga, Mary A Ott, Paula Braitstein
PURPOSE: This study sought to assess whether risky sexual behaviors and sexual exploitation of orphaned adolescents differed between family-based and institutional care environments in Uasin Gishu County, Kenya. METHODS: We analyzed baseline data from a cohort of orphaned adolescents aged 10-18 years living in 300 randomly selected households and 19 charitable children's institutions. The primary outcomes were having ever had consensual sex, number of sex partners, transactional sex, and forced sex...
January 16, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28105067/current-state-and-future-prospects-for-psychosomatic-medicine-in-japan
#20
REVIEW
Masato Murakami, Yoshihide Nakai
In this article, we describe the history and current state of psychosomatic medicine (PSM) in Japan and propose measures that could be considered based on our view of the future prospects of PSM in Japan. The Japanese Society of PSM (JSPM) was established in 1959, and the first Department of Psychosomatic Internal Medicine in Japan was established at Kyushu University In 1963. PSM in Japan has shown a prominent, unique development, with 3,300 members (as of March 2016), comprised of 71.6% of medical doctors including psychosomatic internal medicine (PIM) specialists, general internists, psychiatrists, pediatricians, obstetricians and gynecologists, dentists, dermatologists, and others...
2017: BioPsychoSocial Medicine
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