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Transactional analysis

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https://www.readbyqxmd.com/read/28453527/altered-nucleocytoplasmic-proteome-and-transcriptome-distributions-in-an-in-vitro-model-of-amyotrophic-lateral-sclerosis
#1
Jee-Eun Kim, Yoon Ho Hong, Jin Young Kim, Gye Sun Jeon, Jung Hee Jung, Byung-Nam Yoon, Sung-Yeon Son, Kwang-Woo Lee, Jong-Il Kim, Jung-Joon Sung
Aberrant nucleocytoplasmic localization of proteins has been implicated in many neurodegenerative diseases. Evidence suggests that cytoplasmic mislocalization of nuclear proteins such as transactive response DNA-binding protein 43 (TDP-43) and fused in sarcoma (FUS) may be associated with neurotoxicity in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration. This study investigated the changes in nucleocytoplasmic distributions of the proteome and transcriptome in an in vitro model of ALS...
2017: PloS One
https://www.readbyqxmd.com/read/28448328/hospice-or-community-network-choices-in-end-of-life-care-in-jamaica
#2
Roger Lee Mendoza
AIM: National and international healthcare agencies and organizations typically attribute slow or haphazard growth in hospice and palliative care in developing countries to various resource constraints. This study provides evidence of the substantial and widening gap between policy advocacy and individual decision-making concerning end-of-life care. It does so by establishing the incentives and risks that underlie choices of patients and providers against the relative scarcity of hospices in these countries...
April 26, 2017: International Journal of Evidence-based Healthcare
https://www.readbyqxmd.com/read/28442800/what-puts-them-at-risk-a-cross-sectional-case-control-survey-of-demographic-profile-and-sexual-behavior-of-patients-with-sexually-transmitted-infections-at-a-tertiary-care-center-in-north-india
#3
Rama Raj, Vishal Gupta, Mona Pathak, Vishnubhatla Sreenivas, Seema Sood, Sarman Singh, Kaushal K Verma, Neena Khanna, Bimal K Das, Somesh Gupta
BACKGROUND: Sexually transmitted infections (STIs) are a major public health problem in developing nations. Identification of risk factors can help in formulating effective strategies against them. The present study was conducted in a tertiary care hospital in North India over 1 year to identify the risk factors associated with STIs. MATERIALS AND METHODS: A questionnaire-based cross-sectional case-control survey was conducted where participants answered questions on demographic details, sexual behavior, and awareness of STIs...
January 2017: Indian Journal of Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28419108/changes-in-prices-sales-consumer-spending-and-beverage-consumption-one-year-after-a-tax-on-sugar-sweetened-beverages-in-berkeley-california-us-a-before-and-after-study
#4
Lynn D Silver, Shu Wen Ng, Suzanne Ryan-Ibarra, Lindsey Smith Taillie, Marta Induni, Donna R Miles, Jennifer M Poti, Barry M Popkin
BACKGROUND: Taxes on sugar-sweetened beverages (SSBs) meant to improve health and raise revenue are being adopted, yet evaluation is scarce. This study examines the association of the first penny per ounce SSB excise tax in the United States, in Berkeley, California, with beverage prices, sales, store revenue/consumer spending, and usual beverage intake. METHODS AND FINDINGS: Methods included comparison of pre-taxation (before 1 January 2015) and first-year post-taxation (1 March 2015-29 February 2016) measures of (1) beverage prices at 26 Berkeley stores; (2) point-of-sale scanner data on 15...
April 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28387005/ethical-gifts-an-analysis-of-soap-for-data-transactions-in-malawian-survey-research-worlds
#5
Crystal Biruk
In 2008, thousands of Malawians received soap from an American research project as a gift for survey participation. Soap was deemed an ethical, non-coercive gift by researchers and ethics boards, but took on meanings that expressed recipients' grievances and aspirations. Research participants reframed soap and research benefits as "rights" they are entitled to, wages for "work," and a symbol of exploitation. Enlisting the perspectives of Malawi's ethics board, demographers, Malawian fieldworkers, and research participants, I describe how soap is spoken about and operates in research worlds...
April 7, 2017: Medical Anthropology Quarterly
https://www.readbyqxmd.com/read/28375733/single-molecule-analysis-of-bacterial-dna-repair-and-mutagenesis
#6
Stephan Uphoff, David J Sherratt
Ubiquitous conserved processes that repair DNA damage are essential for the maintenance and propagation of genomes over generations. Then again, inaccuracies in DNA transactions and failures to remove mutagenic lesions cause heritable genome changes. Building on decades of research using genetics and biochemistry, unprecedented quantitative insight into DNA repair mechanisms has come from the new-found ability to measure single proteins in vitro and inside individual living cells. This has brought together biologists, chemists, engineers, physicists, and mathematicians to solve longstanding questions about the way in which repair enzymes search for DNA lesions and form protein complexes that act in DNA repair pathways...
March 24, 2017: Annual Review of Biophysics
https://www.readbyqxmd.com/read/28371896/an-analysis-of-patient-provider-secure-messaging-at-two-veterans-health-administration-medical-centers-message-content-and-resolution-through-secure-messaging
#7
Stephanie L Shimada, Beth Ann Petrakis, James A Rothendler, Maryan Zirkle, Shibei Zhao, Hua Feng, Gemmae M Fix, Mustafa Ozkaynak, Tracey Martin, Sharon A Johnson, Bengisu Tulu, Howard S Gordon, Steven R Simon, Susan S Woods
Objective: We sought to understand how patients and primary care teams use secure messaging (SM) to communicate with one another by analyzing secure message threads from 2 Department of Veterans Affairs facilities. Methods: We coded 1000 threads of SM communication sampled from 40 primary care teams. Results: Most threads (94.5%) were initiated by patients (90.4%) or caregivers (4.1%); only 5.5% were initiated by primary care team members proactively reaching out to patients...
March 24, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/28367944/-original-article-tdp-43-in-the-skin-of-amyotrophic-lateral-sclerosis-patients
#8
Keisuke Abe, Takuya Ohkubo, Takanori Yokota
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease. A common characteristic of ALS pathology is cytoplasmic inclusions primarily composed of transactive response DNA-binding protein of 43 kDa (TDP-43). Production of TDP-43 in the central nervous system is strictly regulated, but it is not known whether this is also true in the skin of ALS patients. We found a gradual but significant reduction in epidermal TDP-43 mRNA expression with illness progression in ALS patients with upper-limb onset...
2017: Journal of Medical and Dental Sciences
https://www.readbyqxmd.com/read/28367747/hiv-risk-and-prevention-among-men-who-have-sex-with-men-in-rural-south-africa
#9
Kabelo Maleke, Nosipho Makhakhe, Remco Ph Peters, Geoffrey Jobson, Glenn De Swardt, Joseph Daniels, Timothy Lane, James A McIntyre, John Imrie, Helen Struthers
Rural South African men who have sex with men (MSM) are likely to be underserved in terms of access to relevant healthcare and HIV prevention services. While research in urban and peri-urban MSM populations has identified a range of factors affecting HIV risk in South African MSM, very little research is available that examines HIV risk and prevention in rural MSM populations. This exploratory study begins to address this lack by assessing perceptions of HIV risk among MSM in rural Limpopo province. Using thematic analysis of interview and discussion data, two overarching global themes that encapsulated participants' understandings of HIV risk and the HIV risk environment in their communities were developed...
March 2017: African Journal of AIDS Research: AJAR
https://www.readbyqxmd.com/read/28367081/changes-of-articular-cartilage-and-subchondral-bone-after-extracorporeal-shockwave-therapy-in-osteoarthritis-of-the-knee
#10
Ching-Jen Wang, Jai-Hong Cheng, Wen-Yi Chou, Shan-Ling Hsu, Jen-Hung Chen, Chien-Yiu Huang
We assessed the pathological changes of articular cartilage and subchondral bone on different locations of the knee after extracorporeal shockwave therapy (ESWT) in early osteoarthritis (OA). Rat knees under OA model by anterior cruciate ligament transaction (ACLT) and medial meniscectomy (MM) to induce OA changes. Among ESWT groups, ESWT were applied to medial (M) femur (F) and tibia (T) condyles was better than medial tibia condyle, medial femur condyle as well as medial and lateral (L) tibia condyles in gross osteoarthritic areas (p<0...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28364932/assessing-stability-and-performance-of-a-digitally-enabled-supply-chain-retrospective-of-a-pilot-in-uttar-pradesh-india
#11
Sarah Skye Gilbert, Neeraj Thakare, Arun Ramanujapuram, Anup Akkihal
BACKGROUND: Immunization supply chains in low resource settings do not always reach children with necessary vaccines. Digital information systems can enable real time visibility of inventory and improve vaccine availability. In 2014, a digital, mobile/web-based information system was implemented in two districts of Uttar Pradesh, India. This retrospective investigates improvements and stabilization of supply chain performance following introduction of the digital information system. METHODS: All data were collected via the digital information system between March 2014 and September 2015...
April 19, 2017: Vaccine
https://www.readbyqxmd.com/read/28330421/the-proteinopathy-of-d169g-and-k263e-mutants-at-the-rna-recognition-motif-rrm-domain-of-tar-dna-binding-protein-tdp43-causing-neurological-disorders-a-computational-study
#12
Vishwambhar Vishnu Bhandare, Amutha Ramaswamy
One of the multitasking proteins, transactive response DNA-binding protein 43 (tdp43) plays a key role in RNA regulation and the two pathogenic mutations such as D169G and K263E, located at the RNA Recognition Motif (RRM) of tdp43, are reported to cause neurological disorders such as Amyotrophic Lateral Sclerosis (ALS) and Fronto Temporal Lobar Degeneration (FTLD). As the exploration of the proteinopathy demands both structural and functional characterization of mutants, a comparative analysis on the wild type and mutant tdp43 (D169G and K263E) and their complexes with RNA have been performed using computational approaches...
March 22, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28321162/mortality-associated-with-gastrointestinal-bleeding-in-children-a-retrospective-cohort-study
#13
Thomas M Attard, Mikaela Miller, Chaitanya Pant, Ashwath Kumar, Mike Thomson
AIM: To determine the clinical characteristics of children with gastrointestinal bleeding (GIB) who died during the course of their admission. METHODS: We interrogated the Pediatric Hospital Information System database, including International Classification of Diseases, Current Procedural Terminology and Clinical Transaction Classification coding from 47 pediatric tertiary centers extracting the population of patients (1-21 years of age) admitted (inpatient or observation) with acute, upper or indeterminate GIB (1/2007-9/2015)...
March 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28294094/market-organization-and-animal-genetic-resource-management-a-revealed-preference-analysis-of-sheep-pricing
#14
K Tindano, N Moula, P Leroy, A Traoré, N Antoine-Moussiaux
Farm animal genetic resources are threatened worldwide. Participation in markets, while representing a crucial way out of poverty for many smallholders, affects genetic management choices with associated sustainability concerns. This paper proposes a contextualized study of the interactions between markets and animal genetic resources management, in the case of sheep markets in Ouagadougou, Burkina Faso. It focusses on the organization of marketing chains and the valuation of genetic characteristics by value chain actors...
March 15, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28288356/the-effect-of-prices-on-nutrition-comparing-the-impact-of-product-and-nutrient-specific-taxes
#15
Matthew Harding, Michael Lovenheim
This paper provides an analysis of the role of prices in determining food purchases and nutrition using very detailed transaction-level observations for a large, nationally-representative sample of US consumers over the period 2002-2007. Using product-specific nutritional information, we develop a new method of partitioning the product space into relevant nutritional clusters that define a set of nutritionally-bundled goods, which parsimoniously characterize consumer choice sets. We then estimate a large utility-derived demand system over this joint product-nutrient space that allows us to calculate price and expenditure elasticities...
February 28, 2017: Journal of Health Economics
https://www.readbyqxmd.com/read/28242115/an-economic-inquisition-of-water-quality-trading-programs-with-a-case-study-of-jordan-lake-nc
#16
Marzieh Motallebi, Dana L Hoag, Ali Tasdighi, Mazdak Arabi, Deanna L Osmond
A water quality trading (WQT) program was promulgated in North Carolina to address water quality issues related to nutrients in the highly urbanizing Jordan Lake Watershed. Although WQT programs are appealing in theory, the concept has not proved feasible in several attempts between point and nonpoint polluters in the United States. Many application hurdles that create wedges between success and failure have been evaluated in the literature. Most programs, however, face multiple hurdles; eliminating one may not clear a pathway to success...
May 15, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28225822/a-reconfiguration-of-the-sex-trade-how-social-and-structural-changes-in-eastern-zimbabwe-left-women-involved-in-sex-work-and-transactional-sex-more-vulnerable
#17
Jocelyn Elmes, Morten Skovdal, Kundai Nhongo, Helen Ward, Catherine Campbell, Timothy B Hallett, Constance Nyamukapa, Peter J White, Simon Gregson
Understanding the dynamic nature of sex work is important for explaining the course of HIV epidemics. While health and development interventions targeting sex workers may alter the dynamics of the sex trade in particular localities, little has been done to explore how large-scale social and structural changes, such as economic recessions-outside of the bounds of organizational intervention-may reconfigure social norms and attitudes with regards to sex work. Zimbabwe's economic collapse in 2009, following a period (2000-2009) of economic decline, within a declining HIV epidemic, provides a unique opportunity to study community perceptions of the impact of socio-economic upheaval on the sex trade...
2017: PloS One
https://www.readbyqxmd.com/read/28222806/internalized-homophobia-mental-health-sexual-behaviors-and-outness-of-gay-bisexual-men-from-southwest-china
#18
Wenjian Xu, Lijun Zheng, Yin Xu, Yong Zheng
BACKGROUND: Social attitudes toward male homosexuality in China so far are still not optimistic. Sexual minorities in China have reported high levels of internalized homophobia. METHODS: This Internet-based study examined the associations among internalized homophobia, mental health, sexual behaviors, and outness among 435 gay/bisexual men in Southwest China from 2014 to 2015. Latent profile analysis, confirmatory factor analysis, univariate logistic regression, and separate multivariate logistic regression analyses were conducted...
February 17, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/28167585/prospectus-towards-the-development-of-high-fidelity-models-of-wall-turbulence-at-large-reynolds-number
#19
J C Klewicki, G P Chini, J F Gibson
Recent and on-going advances in mathematical methods and analysis techniques, coupled with the experimental and computational capacity to capture detailed flow structure at increasingly large Reynolds numbers, afford an unprecedented opportunity to develop realistic models of high Reynolds number turbulent wall-flow dynamics. A distinctive attribute of this new generation of models is their grounding in the Navier-Stokes equations. By adhering to this challenging constraint, high-fidelity models ultimately can be developed that not only predict flow properties at high Reynolds numbers, but that possess a mathematical structure that faithfully captures the underlying flow physics...
March 13, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28155031/-i-got-it-off-my-chest-an-examination-of-how-research-participation-improved-the-mental-health-of-women-engaging-in-transactional-sex
#20
Marisa Felsher, Sarah E Wiehe, Jayleen K L Gunn, Alexis M Roth
Ecologic momentary assessment (EMA) is a form of close-ended diary writing. While it has been shown that participating in a study that incorporates EMA improves mental health of participants, no study to date has examined the pathways through which benefits may occur. For 4-weeks, twice-daily EMAs and weekly interviews captured mood, daily activities and HIV risk behavior of 25 women who engage in transactional sex. Qualitative analysis of exit interviews was performed to examine how participation impacted women's mental health...
February 2, 2017: Community Mental Health Journal
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