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Cavitary tuberculosis

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https://www.readbyqxmd.com/read/28516071/levamisole-as-an-adjuvant-to-short-course-therapy-in-newly-diagnosed-pulmonary-tuberculosis-patients
#1
Chetna Ashok Shamkuwar, Sushant Hiraman Meshram, Sunil M Mahakalkar
BACKGROUND: The estimated incidence and prevalence of tuberculosis in India are 2.1 and 2.6 million cases respectively. Immunotherapy may shorten tuberculosis treatments and improve the immunity of individuals as well. Hence we study the efficacy of levamisole (LVM) (immunomodulator) as an adjuvant to chemotherapy of pulmonary tuberculosis patients. MATERIALS AND METHODS: A randomized, double-blind, placebo-controlled clinical trial was conducted for 21 months in newly diagnosed sputum positive pulmonary tuberculosis patients...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28504669/nitric-oxide-prevents-a-pathogen-permissive-granulocytic-inflammation-during-tuberculosis
#2
Bibhuti B Mishra, Rustin R Lovewell, Andrew J Olive, Guoliang Zhang, Wenfei Wang, Eliseo Eugenin, Clare M Smith, Jia Yao Phuah, Jarukit E Long, Michelle L Dubuke, Samantha G Palace, Jon D Goguen, Richard E Baker, Subhalaxmi Nambi, Rabinarayan Mishra, Matthew G Booty, Christina E Baer, Scott A Shaffer, Veronique Dartois, Beth A McCormick, Xinchun Chen, Christopher M Sassetti
Nitric oxide contributes to protection from tuberculosis. It is generally assumed that this protection is due to direct inhibition of Mycobacterium tuberculosis growth, which prevents subsequent pathological inflammation. In contrast, we report that nitric oxide primarily protects mice by repressing an interleukin-1- and 12/15-lipoxygenase-dependent neutrophil recruitment cascade that promotes bacterial replication. Using M. tuberculosis mutants as indicators of the pathogen's environment, we inferred that granulocytic inflammation generates a nutrient-replete niche that supports M...
May 15, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28449494/clinical-outcomes-for-multi-and-extensively-drug-resistant-tuberculosis-patients-with-adjunctive-resectional-lung-surgery-in-beijing-china
#3
Yan Ma, Yu Pang, Jian Du, Yuhong Liu, Liang Li, Weiwei Gao
The objective of this study was to assess the performance of adjective resectional lung surgery for multidrug resistant (MDR-) and extensively drug resistant tuberculosis (XDR-TB) patients in Beijing, China. Between October 1992 and October 2012, 21 MDR/XDR patients undergoing pulmonary resection at Beijing Chest Hospital were enrolled in this study. The clinical outcomes of MDR- and XDR-TB patients were analyzed with a 3-year surgical follow-up. Out of 21 patients enrolled in this study, 20 patients (95.2%) had unilateral cavitary disease, and 1 patient (4...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28424536/rifapentine-linezolid-loaded-plga-microspheres-for-interventional-therapy-of-cavitary-pulmonary-tuberculosis-preparation-and-in-vitro-characterization
#4
Jieyun Huang, Zhi Chen, Ying Li, Li Li, Guangyu Zhang
In this study, we aimed to design controlled-release microspheres for the treatment of cavitary pulmonary tuberculosis (TB) for solving the issues of poor drug delivery and short duration maintained at effective drug concentration during bronchoscopic interventional therapy. We fabricated rifapentine-linezolid-loaded poly(lactic acid-co-glycolic acid) microspheres (RLPMs) using the oil-in-water emulsion solvent evaporation method and assessed their in vitro release as well as the bronchial mucosal retention characteristics...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28373198/lung-tissue-concentrations-of-pyrazinamide-among-patients-with-drug-resistant-pulmonary-tuberculosis
#5
Russell R Kempker, Marc Tobias Heinrichs, Ketino Nikolaishvili, Irina Sabulua, Nino Bablishvili, Shota Gogishvili, Zaza Avaliani, Nestani Tukvadze, Brent Little, Adam Bernheim, Timothy D Read, Jeannette Guarner, Hartmut Derendorf, Charles A Peloquin, Henry M Blumberg, Sergo Vashakidze
Background: Improved knowledge regarding tissue penetration of anti-tuberculosis drugs may help optimize drug management.Methods: Patients with drug-resistant pulmonary tuberculosis undergoing adjunctive surgery were enrolled. Serial serum samples were collected and microdialysis was performed using ex vivo lung tissue to measure pyrazinamide drug concentrations.Results: Among ten patients, the median pyrazinamide dose was 24.7 mg/kg. Imaging revealed predominant lung lesions as cavitary (6), mass-like (3), or consolidative (1)...
April 3, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28346488/comparison-of-chest-ct-findings-in-nontuberculous-mycobacterial-diseases-vs-mycobacterium-tuberculosis-lung-disease-in-hiv-negative-patients-with-cavities
#6
Cherry Kim, So Hee Park, Sang Young Oh, Sung-Soo Kim, Kyung-Wook Jo, Tae Sun Shim, Mi Young Kim
OBJECTIVES: This article focuses on the differences between CT findings of HIV-negative patients who have cavities with nontuberculous mycobacteria (NTM) disease and those with Mycobacterium tuberculosis infections (TB). METHODS: We retrospectively reviewed 128 NTM disease patients (79 males and 49 females) with cavities in chest CT, matched for age and gender with 128 TB patients in the same period. Sputum cultures of all patients were positive for pathogens. Two independent chest radiologists evaluated the characteristics of the largest cavity and related factors...
2017: PloS One
https://www.readbyqxmd.com/read/28333932/impairment-of-wnt-%C3%AE-catenin-signaling-in-blood-cells-of-patients-with-severe-cavitary-pulmonary-tuberculosis
#7
Lin Fan, Hongbo Shen, Huichang Huang, Rui Yang, Lan Yao
Tuberculosis (TB) remains as a leading infectious disease worldwide. Our previous study showed interferon (IFN)-γ and CD3 T cell impairment in patients with severe cavitary pulmonary TB (PTB). However, the cause of the change in immune responses during the progression of TB is still poorly understood. In this study, eight newly diagnosed patients with severe cavitary and mild lesion non-cavity PTB were recruited, and three healthy volunteers were recruited as the control. RNA extracted from blood was tested by whole genome oligo microarrays...
2017: PloS One
https://www.readbyqxmd.com/read/28261498/tomographic-aspects-of-advanced-active-pulmonary-tuberculosis-and-evaluation-of-sequelae-following-treatment
#8
Rafael Barcelos Capone, Domenico Capone, Thiago Mafort, Roberto Mogami, Rosana de Souza Rodrigues, Miriam Menna Barreto, Rogerio Rufino
Objectives. To evaluate tomographic changes in pulmonary tuberculosis (TB), degree of agreement among three radiologists regarding tomographic diagnoses, and sequelae following treatment. Methods. Cross-sectional and descriptive study of 74 TB patients confirmed by sputum culture and chest computed tomography before (CT1) and 6 months after (CT2) drug therapy. Results were performed by three radiologists blinded to clinical and laboratory results. Results. Main findings in CT1 included nodules indicating the presence of a tree-in-bud pattern in 93% of cases, ill-defined nodules in 84% of cases, consolidation in 77% of cases, architectural distortion in 71% of cases, cavitary lesions in 62% of cases, and ground glass opacities in 37% of cases...
2017: Pulmonary Medicine
https://www.readbyqxmd.com/read/28248043/-clinical-and-morphological-parallels-in-the-validation-of-surgical-treatment-of-nephrotuberculosi
#9
B I Novikov, S N Skornyakov, R B Berdnikov, A V Savelev
AIM: To Study clinical and morphological variants of kidney tuberculosis (KTB), for grounding a tactics of surgical treatment. MATERIALS AND METHODS: There were 107 examined patients (patients with cavitary lesions of kidneys: cavernous and multi-cavernous), operated in different phases of KTB. There were 56 men (52,3%) and women - 51(47,7%). The mean age of patients was 57,6 years (23-84 years). All the patients had a complex examination, including X-ray and ultrasound investigations, computer tomography ( was performed selectively), bacteriological examinations of urine and morphological examinations of removed kidneys or their parts...
December 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28225344/tuberculosis-among-the-homeless-should-we-change-the-strategy
#10
M Dias, R Gaio, P Sousa, M Abranches, M Gomes, O Oliveira, M Correia-Neves, E Ferreira, R Duarte
BACKGROUND: Tuberculosis (TB) is a major concern among high-risk populations such as the homeless. OBJECTIVES: To evaluate TB incidence and treatment outcomes among homeless patients in Portugal and to identify predictors of unsuccessful TB treatment outcomes among the homeless. DESIGN: This was a retrospective cohort study of all TB patients notified in Portugal from 2008 to 2014. Characteristics of homeless TB patients were assessed and predictors of unsuccessful TB treatment were determined using logistic regression...
March 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28203447/computer-automated-algorithm-to-evaluate-cavitary-lesions-in-adults-with-pulmonary-tuberculosis
#11
Alvaro Proaño, Ziyue Xu, Philip Caligiuri, Daniel J Mollura, Robert H Gilman
No abstract text is available yet for this article.
January 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28184994/prevalence-and-impact-of-diabetes-mellitus-among-patients-with-active-pulmonary-tuberculosis-in-south-korea
#12
Eun Hye Lee, Jung Mo Lee, Young Ae Kang, Ah Young Leem, Eun Young Kim, Ji Ye Jung, Moo Suk Park, Young Sam Kim, Se Kyu Kim, Joon Chang, Song Yee Kim
OBJECTIVE: South Korea has an increasing prevalence of diabetes and a relatively high burden of tuberculosis. We aimed to determine the prevalence of diabetes in patients with active pulmonary tuberculosis (PTB) and examine the effect of diabetes on tuberculosis treatment outcomes. SETTING AND DESIGN: Data from patients ≥30 years diagnosed with and treated for PTB between January 2010 and December 2012 at Severance Hospital, a 2000-bed tertiary referral hospital in Seoul, South Korea, were analyzed and compared with data from a contemporaneous general population sample extracted from KNHANES V...
February 9, 2017: Lung
https://www.readbyqxmd.com/read/28166077/a-rare-case-of-bilateral-aspergillomas-in-a-patient-of-ankylosing-spondylitis
#13
A Das, S Pandit, S K Das, S Basuthakur, S Das
Pulmonary involvement by Aspergillus sp. mainly includes allergic bronchopulmonary aspergillosis, aspergilloma, and invasive aspergillosis. Aspergilloma (Fungal ball) is the most common form of aspergillous pulmonary involvement, which occurs in preexisting pulmonary cavities, especially secondary to pulmonary tuberculosis. Ankylosing spondylitis is a rare cause of upper lobe fibro-cavitary lesions in pulmonary parenchyma. It may also lead to development of fungal balls in pulmonary cavities. Most common presentation is mild to massive hemoptysis; dyspnoea, chronic cough, expectoration may be other presentation; even the patient may remain asymptomatic...
April 2016: Kathmandu University Medical Journal (KUMJ)
https://www.readbyqxmd.com/read/28125692/recurrence-after-successful-treatment-of-multidrug-resistant-tuberculosis-in-taiwan
#14
Meng-Yu Chen, Yi-Chun Lo, Wan-Chin Chen, Kwei-Feng Wang, Pei-Chun Chan
Recurrence after successful treatment for multidrug-resistant tuberculosis (MDR-TB) is challenging because of limited retreatment options. This study aimed to determine rates and predictors of MDR-TB recurrence after successful treatment in Taiwan. Recurrence rates were analyzed by time from treatment completion in 295 M DR-TB patients in a national cohort. Factors associated with MDR-TB recurrence were examined using a multivariate Cox regression analysis. Ten (3%) patients experienced MDR-TB recurrence during a median follow-up of 4...
2017: PloS One
https://www.readbyqxmd.com/read/28122644/mtb-specific-lymphocyte-responses-are-impaired-in-tuberculosis-patients-with-pulmonary-cavities
#15
Jun Wang, Yaping Dai, Jun Liu, Yongmei Yin, Hao Pei
OBJECTIVE: Tuberculosis (TB), an infectious disease caused by the bacillus Mycobacterium tuberculosis (MTB), is a global health problem. Because the failing immune response in the lung can lead to formation of a pulmonary cavity, this study was designed to clarify MTB-specific lymphocyte responses in TB patients with pulmonary cavities. METHODS: We utilized culture filtrate protein 10 (CFP-10) and early secretory antigenic target 6 (ESAT-6) as immunogenic MTB antigens following overnight stimulation of peripheral blood mononuclear cells (PBMCs)...
January 26, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/28043593/new-approaches-in-drug-treatment-for-tuberculosis-inhalation-using-liposomes-only-a-future-vision-or-soon-in-clinical-practice
#16
Lars-Olof Larsson
A major change of therapy in respiratory medicine has been the transition from oral or parenteral to inhalation therapy, for example, in asthma. Inhalation of anti-infectious drugs has however not a key-role in the treatment of pulmonary infections such as tuberculosis (TB). The inhalation therapy provides several benefits; the target is reached directly with evasion of first-pass metabolism, thereby resulting in reduced systemic side effects. Furthermore, the drug is delivered to an extensive surface area that is rich in lymphoid tissue...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28025511/immunological-roles-of-elevated-plasma-levels-of-matricellular-proteins-in-japanese-patients-with-pulmonary-tuberculosis
#17
Beata Shiratori, Jingge Zhao, Masao Okumura, Haorile Chagan-Yasutan, Hideki Yanai, Kazue Mizuno, Takashi Yoshiyama, Tadashi Idei, Yugo Ashino, Chie Nakajima, Yasuhiko Suzuki, Toshio Hattori
Elevated matricellular proteins (MCPs), including osteopontin (OPN) and galectin-9 (Gal-9), were observed in the plasma of patients with Manila-type tuberculosis (TB) previously. Here, we quantified plasma OPN, Gal-9, and soluble CD44 (sCD44) by enzyme-linked immunosorbent assay (ELISA), and another 29 cytokines by Luminex assay in 36 patients with pulmonary TB, six subjects with latent tuberculosis (LTBI), and 19 healthy controls (HCs) from Japan for a better understanding of the roles of MCPs in TB. All TB subjects showed positive results of enzyme-linked immunospot assays (ELISPOTs)...
December 22, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28011966/performance-of-real-time-pcr-xpert-%C3%A2-mtb-rif-in-diagnosing-extrapulmonary-tuberculosis
#18
Ester Mazzola, Marco Arosio, Alice Nava, Diana Fanti, Giovanni Gesu, Claudio Farina
The real time PCR Xpert ® MTB/RIF is fundamental for rapid diagnosis in paucibacillary respiratory samples and for the detection of multidrug-resistant TB cases. This paper aimed to determine its performance on different extrapulmonary samples. We determined sensitivity, specificity, positive and negative predictive value on respiratory and non-respiratory samples collected from January 2010 to June 2014. The protocol for the Xpert ® MTB/RIF PCR suggested by Cepheid was strictly followed for all specimens...
December 1, 2016: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/27882294/cough-and-fever-in-an-immigrant-adolescent-with-abnormal-chest-x-ray
#19
Nicole Giles, Rajeev Bhatia
Tuberculosis (TB) remains a leading cause of death from infectious disease worldwide with 80,000 pediatric deaths annually. Disease caused by Mycobacterium tuberculosis (Mtb) is usually asymptomatic in pediatric patients and resolves after completion of standard therapy with isoniazid (INH). Rare reports document children greater than 10 years of age in endemic regions developing adult type cavitary disease, an infectious pulmonary tuberculosis lesion. This is a notable case of post-infectious pulmonary TB disease with adult type cavitation in an immigrant adolescent, which developed even after completing standard therapy with INH...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/27867565/changes-in-cholesterol-level-correlate-with-the-course-of-pulmonary-nontuberculous-mycobacterial-disease
#20
Ji Young Hong, Go Eun Yang, Yousang Ko, Yong Bum Park, Yun Su Sim, Sung Hoon Park, Chang Youl Lee, Ki-Suck Jung, Myung Goo Lee
BACKGROUND: Nutritional assessment is important in patients with pulmonary nontuberculous mycobacterial (PNTM) disease. The therapeutic effect of a cholesterol-rich diet in tuberculosis (TB) patients has been demonstrated, but the role of cholesterol in PNTM disease is unclear. This study evaluated the sequential changes in nutritional markers, including cholesterol, total lymphocyte count and visceral fat volume, according to the PNTM disease course. METHODS: This was an age-, sex- and number of comorbid diseases-matched case-control analysis of 89 patients with PNTM disease and 356 controls, who were participants in a Korean national survey...
October 2016: Journal of Thoracic Disease
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