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Keywords Pic,perioperative intraperiton...

Pic,perioperative intraperitoneal chemotherapy

https://read.qxmd.com/read/20737573/toward-curative-treatment-of-peritoneal-carcinomatosis-from-nonovarian-origin-by-cytoreductive-surgery-combined-with-perioperative-intraperitoneal-chemotherapy-a-multi-institutional-study-of-1-290-patients
#21
MULTICENTER STUDY
Olivier Glehen, François N Gilly, Florent Boutitie, Jean M Bereder, François Quenet, Lucas Sideris, Baudouin Mansvelt, Gérard Lorimier, Simon Msika, Dominique Elias
BACKGROUND: Peritoneal carcinomatosis (PC) from nonovarian malignancies long has been regarded as a terminal disease. Over the past decade, new locoregional therapeutic approaches combining cytoreductive surgery with perioperative intraperitoneal chemotherapy (PIC) have evolved that have demonstrated improved survival. METHODS: A retrospective, multicenter cohort study was performed in French-speaking institutions to evaluate toxicity and principal prognostic factors after cytoreductive surgery and PIC (hyperthermic intraperitoneal chemotherapy [HIPEC] and/or early postoperative intraperitoneal chemotherapy [EPIC]) for PC from nongynecologic malignancies...
December 15, 2010: Cancer
https://read.qxmd.com/read/20729102/secondary-cytoreduction-and-perioperative-intraperitoneal-chemotherapy-after-initial-debulking-of-pseudomyxoma-peritonei-a-study-of-timing-and-the-impact-of-malignant-dedifferentiation
#22
JOURNAL ARTICLE
Terence C Chua, Abdulaziz Al-Zahrani, Akshat Saxena, Winston Liauw, Jing Zhao, David L Morris
BACKGROUND: Cytoreductive surgery and perioperative intraperitoneal chemotherapy (PIC) is recognized as an effective treatment modality for patients with pseudomyxoma peritonei. This study investigates its role as a secondary definitive treatment procedure after earlier primary treatments. STUDY DESIGN: Patients with pseudomyxoma peritonei undergoing secondary cytoreduction combined with PIC were identified from a prospective database. Retrospective analysis investigated the outcomes, prognostic factors, critical time points, and impact of malignant dedifferentiation...
October 2010: Journal of the American College of Surgeons
https://read.qxmd.com/read/20336386/peritoneal-carcinomatosis-from-gastric-cancer-a-multi-institutional-study-of-159-patients-treated-by-cytoreductive-surgery-combined-with-perioperative-intraperitoneal-chemotherapy
#23
MULTICENTER STUDY
Olivier Glehen, François Noel Gilly, Catherine Arvieux, Eddy Cotte, Florent Boutitie, Baudouin Mansvelt, Jean Marc Bereder, Gérard Lorimier, François Quenet, Dominique Elias
BACKGROUND: Peritoneal carcinomatosis (PC) from gastric cancer has long been regarded a terminal disease with a short median survival. New locoregional therapeutic approaches combining cytoreductive surgery with perioperative intraperitoneal chemotherapy (PIC) have evolved and suggest improved survival. MATERIALS AND METHODS: A retrospective multicentric study was performed in French-speaking centers to evaluate the toxicity and the principal prognostic factors in order to identify the best indications...
September 2010: Annals of Surgical Oncology
https://read.qxmd.com/read/20227231/pseudomyxoma-peritonei-a-french-multicentric-study-of-301-patients-treated-with-cytoreductive-surgery-and-intraperitoneal-chemotherapy
#24
MULTICENTER STUDY
D Elias, F Gilly, F Quenet, J M Bereder, L Sidéris, B Mansvelt, G Lorimier, O Glehen
OBJECTIVE: To analyze a large series of patients with pseudomyxoma peritonei (PMP) treated with cytoreductive surgery associated with perioperative intraperitoneal chemotherapy (PIC) in 18 French-speaking centers. PATIENTS AND METHODS: From March 1993 to December 2007, 301 patients with diffuse PMP were treated by cytoreductive surgery with PIC. Complete cytoreductive surgery was achieved in 219 patients (73%), and hyperthermic intraperitoneal chemotherapy (HIPEC) was performed in 255 (85%), mainly during the latter period of the study...
May 2010: European Journal of Surgical Oncology
https://read.qxmd.com/read/20087784/postoperative-pancreatic-fistula-after-cytoreductive-surgery-and-perioperative-intraperitoneal-chemotherapy-incidence-risk-factors-management-and-clinical-sequelae
#25
JOURNAL ARTICLE
Akshat Saxena, Terence C Chua, Tristan D Yan, David L Morris
BACKGROUND: Cytoreductive surgery (CRS) and perioperative intraperitoneal chemotherapy (PIC) has improved survival in selected patients with peritoneal carcinomatosis. This study evaluates the morbidity of postoperative pancreatic fistula (PF) within the context of CRS and PIC. METHODS: Two hundred seventy-one consecutive CRS and PIC procedures were evaluated. Diagnosis and classification of postoperative PF were performed according to the international study group on PF criteria...
May 2010: Annals of Surgical Oncology
https://read.qxmd.com/read/20039212/critical-assessment-of-risk-factors-for-complications-after-cytoreductive-surgery-and-perioperative-intraperitoneal-chemotherapy-for-pseudomyxoma-peritonei
#26
JOURNAL ARTICLE
Akshat Saxena, Tristan D Yan, Terence C Chua, David L Morris
BACKGROUND: Cytoreductive surgery (CRS) combined with perioperative intraperitoneal chemotherapy (PIC) has demonstrated improved survival in selected patients with pseudomyxoma peritonei (PMP). However, this aggressive treatment modality has been consistently associated with variable rates of perioperative mortality between 0% and 18% and morbidity between 30% and 70%. This study evaluates the clinical and treatment-related risk factors for perioperative morbidity and mortality in PMP patients who underwent CRS and PIC...
May 2010: Annals of Surgical Oncology
https://read.qxmd.com/read/19917863/peritoneal-colorectal-carcinomatosis-treated-with-surgery-and-perioperative-intraperitoneal-chemotherapy-retrospective-analysis-of-523-patients-from-a-multicentric-french-study
#27
MULTICENTER STUDY
Dominique Elias, François Gilly, Florent Boutitie, François Quenet, Jean-Marc Bereder, Baudouin Mansvelt, Gérard Lorimier, Pierre Dubè, Olivier Glehen
PURPOSE Peritoneal carcinomatosis (PC) from colorectal cancer traditionally is considered a terminal condition. Approaches that combine cytoreductive surgery (CRS) and perioperative intraperitoneal chemotherapy (PIC) have been developed recently. The purpose of this study was to assess early and long-term survival in patients treated with that strategy. PATIENTS AND METHODS A retrospective-cohort, multicentric study from French-speaking countries was performed. All consecutive patients with PC from colorectal cancer who were treated with CRS and PIC (with or without hyperthermia) were included...
January 1, 2010: Journal of Clinical Oncology
https://read.qxmd.com/read/19838105/morbidity-and-mortality-outcomes-of-cytoreductive-surgery-and-perioperative-intraperitoneal-chemotherapy-at-a-single-tertiary-institution-towards-a-new-perspective-of-this-treatment
#28
JOURNAL ARTICLE
Terence C Chua, Akshat Saxena, J F Schellekens, Winston Liauw, Tristan D Yan, Sal Fransi, Jing Zhao, David L Morris
INTRODUCTION: Cytoreductive surgery (CRS) combined with perioperative intraperitoneal chemotherapy (PIC) is a treatment option for peritoneal surface malignancy. Despite the survival benefits, this treatment was previously associated with a high morbidity and mortality rates and the perception of the poor perioperative outcomes associated with this regimen remains. The aim of this study was to report the perioperative outcomes of CRS and PIC from a single institution to review factors that are associated with a poor perioperative outcome...
January 2010: Annals of Surgery
https://read.qxmd.com/read/19760317/a-critical-evaluation-of-risk-factors-for-complications-after-cytoreductive-surgery-and-perioperative-intraperitoneal-chemotherapy-for-colorectal-peritoneal-carcinomatosis
#29
JOURNAL ARTICLE
Akshat Saxena, Tristan D Yan, David L Morris
BACKGROUND: Cytoreductive surgery (CRS) combined with perioperative intraperitoneal chemotherapy (PIC) has demonstrated improved survival in selected patients with colorectal peritoneal carcinomatosis (CRPC). This treatment modality is associated with relatively high rates of perioperative morbidity and mortality. This study evaluated the clinical and treatment-related risk factors for perioperative morbidity and mortality in patients with CRPC who underwent CRS and PIC. METHODS: Sixty-three consecutive patients who underwent CRS and PIC for CRPC were evaluated...
January 2010: World Journal of Surgery
https://read.qxmd.com/read/19697395/comparison-of-optimally-resected-hepatectomy-and-peritonectomy-patients-with-colorectal-cancer-metastasis
#30
COMPARATIVE STUDY
Christopher Q Cao, Tristan D Yan, Winston Liauw, David L Morris
BACKGROUND: Hepatectomy is the standard of care for patients with colorectal liver metastases (CRLM) but cytoreductive surgery (CRS) and perioperative intraperitoneal chemotherapy (PIC) are still not widely accepted as the definitive treatment for patients with peritoneal carcinomatosis of colorectal origin (CRPC). We analyzed our data to compare survival outcomes for patients in these two groups who achieved optimal resection. METHODS: We examined our prospectively collected database for CRLM and CRPC patients who underwent hepatectomy or peritonectomy from 1995 to 2008...
December 1, 2009: Journal of Surgical Oncology
https://read.qxmd.com/read/19632081/peritoneal-carcinomatosis-and-liver-metastases-from-colorectal-cancer-treated-with-cytoreductive-surgery-perioperative-intraperitoneal-chemotherapy-and-liver-resection
#31
COMPARATIVE STUDY
T C Chua, T D Yan, J Zhao, D L Morris
BACKGROUND: An aggressive therapy comprising of cytoreductive surgery (CRS) and perioperative intraperitoneal chemotherapy (PIC) and liver resection/ablation is generally not offered to patients with both colorectal peritoneal carcinomatosis (CRPC) and liver metastases (LM) as it no longer represents a loco-regional disease. We review the outcomes of patients who underwent an aggressive treatment with a curative intent for both CRPC and LM as a prelude towards determining the suitability of this treatment...
December 2009: European Journal of Surgical Oncology
https://read.qxmd.com/read/19615849/critical-assessment-of-preoperative-and-operative-risk-factors-for-complications-after-iterative-peritonectomy-procedures
#32
COMPARATIVE STUDY
A Saxena, T D Yan, D L Morris
AIMS: This study is the first to evaluate the clinical and treatment-related risk factors for perioperative toxicity and mortality in patients with peritoneal recurrence that underwent iterative cytoreductive surgery (CRS) with or without perioperative intraperitoneal chemotherapy (PIC). The aim is to improve patient selection. METHODS: Fifty-seven consecutive iterative CRS procedures were performed in 40 patients between June 2000 and September 2008. Forty-seven patients were administered PIC...
March 2010: European Journal of Surgical Oncology
https://read.qxmd.com/read/19544356/cytoreductive-surgery-and-perioperative-intraperitoneal-chemotherapy-for-peritoneal-carcinomatosis-from-small-bowel-adenocarcinoma
#33
JOURNAL ARTICLE
Terence C Chua, Ju-Li Koh, Tristan D Yan, Winston Liauw, David L Morris
BACKGROUND: Small bowel adenocarcinoma is a rare malignancy that presents both a diagnostic and therapeutic challenge. The late presentation is often associated with disseminated carcinomatosis which is regarded a terminal event. We review our experience with small bowel peritoneal carcinomatosis following treatment with cytoreductive surgery (CRS) and perioperative intraperitoneal chemotherapy (PIC). METHODS: From a prospective database of CRS and PIC, seven patients were identified to have undergone treatment for small bowel peritoneal carcinomatosis with CRS and hyperthermic intraperitoneal chemotherapy (Mitomycin C) and early postoperative intraperitoneal chemotherapy (5FU)...
August 1, 2009: Journal of Surgical Oncology
https://read.qxmd.com/read/19434455/a-systematic-review-and-meta-analysis-of-cytoreductive-surgery-with-perioperative-intraperitoneal-chemotherapy-for-peritoneal-carcinomatosis-of-colorectal-origin
#34
REVIEW
Christopher Cao, Tristan D Yan, Deborah Black, David L Morris
BACKGROUND: The objective of the present meta-analysis was to analyze the survival outcomes of patients with colorectal peritoneal carcinomatosis (CRPC), with particular focus on cytoreductive surgery (CRS) and perioperative intraperitoneal chemotherapy (PIC). METHODS: A search was conducted on Medline from 1950 to February 2009 and Pubmed from 1950 to February 2009 for original studies on CRS with PIC. All articles included in this study were assessed with the application of predetermined selection criteria...
August 2009: Annals of Surgical Oncology
https://read.qxmd.com/read/19412567/significance-of-lymph-node-metastasis-in-patients-with-colorectal-cancer-peritoneal-carcinomatosis
#35
COMPARATIVE STUDY
Terence C Chua, Tristan D Yan, Keh M Ng, Jing Zhao, David L Morris
BACKGROUND: Lymph node metastasis is common in patients with colorectal cancer. Its significance in patients at the time of primary colorectal surgery and later in patients who develop colorectal cancer peritoneal carcinomatosis (CRPC) is unknown. Lymphatic metastasis reflects a systemic spread of cancer and its implication on patients who undergo cytoreductive surgery (CRS) and perioperative intraperitoneal chemotherapy (PIC) for carcinomatosis needs to be studied. METHODS: Patients with CRPC underwent CRS and PIC according to a standardized treatment protocol in our institution...
July 2009: World Journal of Surgery
https://read.qxmd.com/read/19408046/risk-factors-for-massive-blood-transfusion-in-cytoreductive-surgery-a-multivariate-analysis-of-243-procedures
#36
JOURNAL ARTICLE
Akshat Saxena, Tristan D Yan, Terence C Chua, Sal Fransi, Khaled Almohaimeed, Sulman Ahmed, David L Morris
BACKGROUND: Cytoreductive surgery (CRS) combined with perioperative intraperitoneal chemotherapy (PIC) has demonstrated improved survival in selected patients with peritoneal carcinomatosis (PC). This treatment modality is associated with high blood loss and often requires massive allogenic red blood cell transfusion (MABT). Our study is the first of its kind to evaluate the risk factors for intraoperative MABT in peritonectomy procedures. METHODS: Two hundred and forty-three consecutive CRS and PIC procedures were evaluated...
August 2009: Annals of Surgical Oncology
https://read.qxmd.com/read/19387742/long-term-survival-in-patients-with-pseudomyxoma-peritonei-treated-with-cytoreductive-surgery-and-perioperative-intraperitoneal-chemotherapy-10-years-of-experience-from-a-single-institution
#37
JOURNAL ARTICLE
Terence C Chua, Tristan D Yan, Michelle E Smigielski, Katherine J Zhu, Keh M Ng, Jing Zhao, David L Morris
BACKGROUND: Cytoreductive surgery (CRS) and perioperative intraperitoneal chemotherapy (PIC) has been recognized as a treatment option for pseudomyxoma peritonei. This study reports the survival outcomes, clinicopathological prognostic factors, and a learning curve from a single institution's experience. METHODS: Patients with pseudomyxoma peritonei underwent CRS and PIC, which was comprised of hyperthermic intraperitoneal chemotherapy (HIPEC) and/or early postoperative intraperitoneal chemotherapy (EPIC), according to a standardized treatment protocol in our institution...
July 2009: Annals of Surgical Oncology
https://read.qxmd.com/read/17541772/critical-analysis-of-treatment-failure-after-complete-cytoreductive-surgery-and-perioperative-intraperitoneal-chemotherapy-for-peritoneal-dissemination-from-appendiceal-mucinous-neoplasms
#38
COMPARATIVE STUDY
Tristan D Yan, Lana Bijelic, Paul H Sugarbaker
BACKGROUND: Cytoreductive surgery (CRS) combined with perioperative intraperitoneal chemotherapy (PIC) has been suggested as a treatment strategy for peritoneal carcinomatosis. The objective of this data analysis was to study treatment failure after complete cytoreduction for peritoneal dissemination from appendiceal mucinous neoplasms. METHODS: Before June 2006, a total of 402 patients with peritoneal dissemination from appendiceal mucinous neoplasms underwent complete cytoreduction and PIC at the Washington Cancer Institute...
August 2007: Annals of Surgical Oncology
https://read.qxmd.com/read/17503156/failure-analysis-of-recurrent-disease-following-complete-cytoreduction-and-perioperative-intraperitoneal-chemotherapy-in-patients-with-peritoneal-carcinomatosis-from-colorectal-cancer
#39
COMPARATIVE STUDY
Lana Bijelic, Tristan D Yan, Paul H Sugarbaker
BACKGROUND: The aim of this study was to analyze the anatomic distribution, timing, and outcomes of recurrent disease after complete cytoreduction and perioperative intraperitoneal chemotherapy (PIC) for peritoneal carcinomatosis of colorectal origin. METHODS: Data regarding all patients who underwent complete cytoreduction and PIC for carcinomatosis from colorectal cancer were extracted from a prospectively collected database. The information regarding recurrent disease found on diagnostic evaluation and/or abdominal exploration was analyzed...
August 2007: Annals of Surgical Oncology
https://read.qxmd.com/read/17464543/learning-curve-for-cytoreductive-surgery-and-perioperative-intraperitoneal-chemotherapy-for-peritoneal-surface-malignancy-a-journey-to-becoming-a-nationally-funded-peritonectomy-center
#40
COMPARATIVE STUDY
Tristan D Yan, Matthew Links, Sal Fransi, Theresa Jacques, Deborah Black, Vanessa Saunders, David L Morris
BACKGROUND: Cytoreductive surgery (CRS) combined with perioperative intraperitoneal chemotherapy (PIC) for peritoneal surface malignancy is associated with a morbidity rate of 30-50% and a mortality rate of 1-10%. Recently, the St George Hospital in Sydney has been commissioned as the Nationally Funded Center for treatment of peritoneal surface malignancy in Australia. METHODS: The clinical and treatment-related data regarding 140 consecutive patients were prospectively collected...
August 2007: Annals of Surgical Oncology
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