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Pic,perioperative intraperitoneal chemotherapy

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https://www.readbyqxmd.com/read/27718032/early-postoperative-intraperitoneal-chemotherapy-for-low-grade-appendiceal-mucinous-neoplasms-with-pseudomyxoma-peritonei-is-it-beneficial
#1
Yeqian Huang, Nayef A Alzahrani, Winston Liauw, Thamer B Traiki, David L Morris
BACKGROUND: There is little evidence for the use of early postoperative intraperitoneal chemotherapy (EPIC) in patients with low-grade appendiceal mucinous neoplasms (LAMNs) with pseudomyxoma peritonei (PMP). This study aims to assess the outcomes regarding the use of EPIC in a large cohort of patients with LAMNs with PMP uniformly treated by cytoreductive surgery (CRS) and perioperative intraperitoneal chemotherapy (PIC), all of whom received hyperthermic intraperitoneal chemotherapy (HIPEC), and most of whom also received EPIC...
October 7, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27353848/impacts-of-peritoneal-cancer-index-on-the-survival-outcomes-of-patients-with-colorectal-peritoneal-carcinomatosis
#2
Yeqian Huang, Nayef A Alzahrani, Terence C Chua, Winston Liauw, David L Morris
INTRODUCTION: Peritoneal cancer index (PCI) has been suggested to be the most important prognostic factors for the outcomes in colorectal peritoneal carcinomatosis (CRPC). METHODS: This was a retrospective study of prospectively collected data of 168 consecutive patients with CRPC following cytoreductive surgery (CRS) and perioperative intraperitoneal chemotherapy (PIC). Patients were divided into five groups according to their PCI. RESULTS: Hospital mortality was 0%...
August 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/26976995/clinical-outcomes-of-patients-with-extensive-peritoneal-carcinomatosis-following-cytoreductive-surgery-and-perioperative-intraperitoneal-chemotherapy
#3
Yeqian Huang, Nayef A Alzahrani, Terence C Chua, Ya Ruth Huo, David L Morris
AIM: The aims of this study were to explore clinical outcomes and assess the learning curve for cytoreductive surgery and perioperative intraperitoneal chemotherapy (PIC) for patients with a high peritoneal cancer index (PCI). PATIENTS AND METHODS: This was a retrospective study of patients with a PCI of 20 or more following CRS and PIC. Outcomes in five successive groups based on the operation date were analyzed. RESULTS: Three hundred and five patients were included in the study...
March 2016: Anticancer Research
https://www.readbyqxmd.com/read/26957502/impacts-of-preoperative-serum-albumin-level-on-outcomes-of-cytoreductive-surgery-and-perioperative-intraperitoneal-chemotherapy
#4
Yeqian Huang, Nayef A Alzahrani, Terence C Chua, Ya Ruth Huo, Winston Liauw, David L Morris
BACKGROUND: Only few small studies in the literature have explored the impacts of preoperative serum albumin level and clinical outcomes of patients with peritoneal surface malignancy (PSM) who underwent cytoreductive surgery (CRS) and perioperative intraperitoneal chemotherapy (PIC). This study aimed to evaluate the value of preoperative serum albumin as a prognostic factor for long-term survival outcomes after CRS and PIC in a large patient cohort and to determine whether preoperative serum albumin is correlated with perioperative complications...
August 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/26333628/learning-curve-for-cytoreductive-surgery-and-perioperative-intraperitoneal-chemotherapy-for-peritoneal-carcinomatosis
#5
Yeqian Huang, Nayef A Alzahrani, Winston Liauw, David L Morris
BACKGROUND: Combined cytoreductive surgery (CRS) and perioperative intraperitoneal chemotherapy (PIC) has been considered as a standard approach for peritoneal surface malignancy. This study aims to assess the learning curve of this combined approach. METHODS: Prospectively collected data of our first 800 consecutive patients treated by CRS and PIC between January 1996 and July 2014 were retrospectively reviewed. Eight hundred patients were divided into two groups and eight groups for comparison...
September 2, 2015: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/26311565/cytoreductive-surgery-and-perioperative-intraperitoneal-chemotherapy-for-peritoneal-carcinomatosis-in-the-elderly
#6
Yeqian Huang, Nayef A Alzahrani, Saleh E Alzahrani, Jing Zhao, Winston Liauw, David L Morris
BACKGROUND: Peritoneal carcinomatosis is life-threatening without cytoreductive surgery (CRS) and perioperative intraperitoneal chemotherapy (PIC). Only a few studies in the literature addressed the relationship between age and outcomes of peritonectomy. This study was designed to review the clinical outcomes in elderly patients who underwent CRS and PIC. METHODS: This is a retrospective study of prospectively collected data of 611 consecutive patients with peritoneal carcinomatosis who underwent CRS and PIC by the same surgical team at St George Hospital in Sydney, Australia, between January 1996 and December 2013...
2015: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/24218093/-morbidity-and-mortality-of-hyperthermic-intraperitoneal-chemoperfusion
#7
REVIEW
J O W Pelz, C-T Germer
Cytoreductive surgery (CRS) combined with perioperative intraperitoneal chemotherapy (PIC) is a treatment option for peritoneal surface malignancy. Despite the survival benefits, this treatment was previously associated with a high morbidity and mortality rates, and the perception of the poor perioperative outcomes associated with this regimen remains. Careful patient selection with an optimal level of postoperative care must be advocated to avoid undesirable complications of this treatment.However, for this treatment to be accepted as standard of care, teams undertaking this treatment strategy must aim to minimize morbidity and mortality by learning from the experience of established centers and using the "global learning curve"...
November 2013: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/23730513/carbohydrate-antigen-19-9-ca-19-9-is-an-independent-prognostic-indicator-in-pseudomyxoma-peritonei-post-cytoreductive-surgery-and-perioperative-intraperitoneal-chemotherapy
#8
Ju-Li Koh, Winston Liauw, Terence Chua, David L Morris
INTRODUCTION: Pseudomyxoma peritonei (PMP) is characteristically divided into two histopathological subtypes; disseminated peritoneal adenomucinosis (DPAM) and peritoneal mucinous carcinomatosis (PMCA). The latter is associated with a worse prognosis. However, even within the DPAM group, there is a considerable variation in outcome. In this study we investigate the role of baseline serum tumor markers CA 19-9, CEA and CA-125 in further stratifying survival. METHODS: Over 16 years, 218 patients with PMP were treated with cytoreductive surgery (CRS) and perioperative intraperitoneal chemotherapy (PIC) at our institution...
June 2013: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/23449950/effectiveness-of-early-and-aggressive-administration-of-fresh-frozen-plasma-to-reduce-massive-blood-transfusion-during-cytoreductive-surgery
#9
Akshat Saxena, Terence C Chua, Salwan Fransi, Winston Liauw, David L Morris
BACKGROUND: Cytoreductive surgery (CRS) combined with perioperative intraperitoneal chemotherapy (PIC) has been consistently associated with high volume blood loss and red blood cell (RBC) transfusion. This study evaluates the effectiveness of the introduction of a novel protocol to reduce blood loss and subsequent intra-operative transfusion in patients with high volume disease. METHODS: One hundred and thirty-one consecutive patients with high volume disease (peritoneal cancer index ≥16) who underwent CRS and PIC were evaluated...
March 2013: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/22763244/evaluation-of-complete-cytoreductive-surgery-and-two-intraperitoneal-chemotherapy-techniques-in-pseudomyxoma-peritonei
#10
COMPARATIVE STUDY
O Sørensen, K Flatmark, W Reed, J N Wiig, S Dueland, K-E Giercksky, S G Larsen
BACKGROUND: Pseudomyxoma peritonei (PMP) is a low-grade malignancy characterized by mucinous tumor on the peritoneal surface. Treatment involves cytoreductive surgery (CRS) to remove all macroscopic tumor and perioperative intraperitoneal chemotherapy (PIC) to eliminate remaining microscopic disease. PATIENTS AND METHODS: Between 1994 and 2009, 93 patients were treated at the Norwegian Radium Hospital with complete CRS and PIC. PIC was administered as early postoperative intraperitoneal chemotherapy (EPIC) using mitomycin C (MMC) and 5-fluoruracil (n = 48) and as hyperthermic intraperitoneal chemotherapy (HIPEC) using MMC (n = 45)...
October 2012: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/22415741/comparative-analysis-of-perioperative-intraperitoneal-chemotherapy-regimen-in-appendiceal-and-colorectal-peritoneal-carcinomatosis
#11
Terence C Chua, Winston Liauw, Jing Zhao, David L Morris
BACKGROUND: Perioperative intraperitoneal chemotherapy (PIC) is delivered by intraoperative hyperthermic intraperitoneal chemotherapy (HIPEC) and early postoperative intraperitoneal chemotherapy (EPIC). The relative survival benefits of each or both regimens are explored in this large series of patients undergoing cytoreduction at a single institution. METHODS: Patients with a complete (CCR0) or optimal (CCR1) cytoreduction who received intraperitoneal chemotherapy for appendiceal and colorectal peritoneal carcinomatosis were included for analysis...
June 2013: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/21780124/outcomes-of-elderly-patients-undergoing-cytoreductive-surgery-and-perioperative-intraperitoneal-chemotherapy-for-colorectal-cancer-peritoneal-carcinomatosis
#12
Yvonne L B Klaver, Terence C Chua, Ignace H J T de Hingh, David L Morris
BACKGROUND: The combined treatment of cytoreductive surgery (CRS) and perioperative chemotherapy (PIC) for colorectal peritoneal carcinomatosis (PC) is a rigorous surgical treatment most suited for fit and young patients. With technical maturity and improved perioperative care, we examined the outcomes of elderly patients undergoing CRS and PIC for colorectal PC. METHODS: All consecutive patients treated in two tertiary centers for PC of colorectal cancer who were 70 years of age or older at the time of surgery were included...
February 2012: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/21475018/upfront-compared-to-delayed-cytoreductive-surgery-and-perioperative-intraperitoneal-chemotherapy-for-pseudomyxoma-peritonei-is-associated-with-considerably-lower-perioperative-morbidity-and-recurrence-rate
#13
COMPARATIVE STUDY
Terence C Chua, Winston Liauw, Jing Zhao, David L Morris
BACKGROUND: Cytoreductive surgery (CRS) combined with perioperative intraperitoneal chemotherapy (PIC) is a recognized management strategy for pseudomyxoma peritonei. We seek to evaluate the outcomes of patients treated upfront with CRS PIC compared to patients undergoing delayed CRS PIC as salvage or treatment for recurrences after initial debulking surgery. METHODS: Retrospective analysis of patients with low-grade pseudomyxoma peritonei treated within our institution were stratified according to upfront versus delayed CRS PIC after intial debulking surgery...
April 2011: Annals of Surgery
https://www.readbyqxmd.com/read/21283990/diffuse-malignant-peritoneal-mesothelioma-systematic-review-of-clinical-management-and-biological-research
#14
REVIEW
Dario Baratti, Shigeki Kusamura, Marcello Deraco
Diffuse malignant peritoneal mesothelioma (DMPM) is an uncommon and locally aggressive tumor with poor prognosis. Currently, no standard therapy is available. The biology of this disease is still poorly understood. We performed a systematic search of relevant studies on clinical management and biological research of DMPM. Trials were selected using a predetermined protocol. The current evidence suggests that cytoreductive surgery (CRS) and perioperative intraperitoneal chemotherapy (PIC) results in improved survival...
June 2011: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/20832051/evolution-of-locoregional-treatment-for-peritoneal-carcinomatosis-single-center-experience-of-308-procedures-of-cytoreductive-surgery-and-perioperative-intraperitoneal-chemotherapy
#15
Terence C Chua, Winston Liauw, Akshat Saxena, Khalid Al-Mohaimeed, Salawan Fransi, Jing Zhao, David L Morris
BACKGROUND: Peritoneal carcinomatosis imposes an enormous clinical burden to the oncologic community. This study reports the patterns of care of the locoregional approach of cytoreductive surgery (CRS) and perioperative intraperitoneal chemotherapy as a curative procedure for peritoneal carcinomatosis from the experience of a single tertiary center in Australia. METHODS: We performed a review of clinical records from a prospective database of patients who were treated at the St George Hospital Peritoneal Surface Malignancy Program according to a standard protocol...
February 2011: American Journal of Surgery
https://www.readbyqxmd.com/read/20737573/toward-curative-treatment-of-peritoneal-carcinomatosis-from-nonovarian-origin-by-cytoreductive-surgery-combined-with-perioperative-intraperitoneal-chemotherapy-a-multi-institutional-study-of-1-290-patients
#16
MULTICENTER STUDY
Olivier Glehen, François N Gilly, Florent Boutitie, Jean M Bereder, François Quenet, Lucas Sideris, Baudouin Mansvelt, Gérard Lorimier, Simon Msika, Dominique Elias
BACKGROUND: Peritoneal carcinomatosis (PC) from nonovarian malignancies long has been regarded as a terminal disease. Over the past decade, new locoregional therapeutic approaches combining cytoreductive surgery with perioperative intraperitoneal chemotherapy (PIC) have evolved that have demonstrated improved survival. METHODS: A retrospective, multicenter cohort study was performed in French-speaking institutions to evaluate toxicity and principal prognostic factors after cytoreductive surgery and PIC (hyperthermic intraperitoneal chemotherapy [HIPEC] and/or early postoperative intraperitoneal chemotherapy [EPIC]) for PC from nongynecologic malignancies...
December 15, 2010: Cancer
https://www.readbyqxmd.com/read/20729102/secondary-cytoreduction-and-perioperative-intraperitoneal-chemotherapy-after-initial-debulking-of-pseudomyxoma-peritonei-a-study-of-timing-and-the-impact-of-malignant-dedifferentiation
#17
Terence C Chua, Abdulaziz Al-Zahrani, Akshat Saxena, Winston Liauw, Jing Zhao, David L Morris
BACKGROUND: Cytoreductive surgery and perioperative intraperitoneal chemotherapy (PIC) is recognized as an effective treatment modality for patients with pseudomyxoma peritonei. This study investigates its role as a secondary definitive treatment procedure after earlier primary treatments. STUDY DESIGN: Patients with pseudomyxoma peritonei undergoing secondary cytoreduction combined with PIC were identified from a prospective database. Retrospective analysis investigated the outcomes, prognostic factors, critical time points, and impact of malignant dedifferentiation...
October 2010: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/20336386/peritoneal-carcinomatosis-from-gastric-cancer-a-multi-institutional-study-of-159-patients-treated-by-cytoreductive-surgery-combined-with-perioperative-intraperitoneal-chemotherapy
#18
MULTICENTER STUDY
Olivier Glehen, François Noel Gilly, Catherine Arvieux, Eddy Cotte, Florent Boutitie, Baudouin Mansvelt, Jean Marc Bereder, Gérard Lorimier, François Quenet, Dominique Elias
BACKGROUND: Peritoneal carcinomatosis (PC) from gastric cancer has long been regarded a terminal disease with a short median survival. New locoregional therapeutic approaches combining cytoreductive surgery with perioperative intraperitoneal chemotherapy (PIC) have evolved and suggest improved survival. MATERIALS AND METHODS: A retrospective multicentric study was performed in French-speaking centers to evaluate the toxicity and the principal prognostic factors in order to identify the best indications...
September 2010: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/20227231/pseudomyxoma-peritonei-a-french-multicentric-study-of-301-patients-treated-with-cytoreductive-surgery-and-intraperitoneal-chemotherapy
#19
MULTICENTER STUDY
D Elias, F Gilly, F Quenet, J M Bereder, L Sidéris, B Mansvelt, G Lorimier, O Glehen
OBJECTIVE: To analyze a large series of patients with pseudomyxoma peritonei (PMP) treated with cytoreductive surgery associated with perioperative intraperitoneal chemotherapy (PIC) in 18 French-speaking centers. PATIENTS AND METHODS: From March 1993 to December 2007, 301 patients with diffuse PMP were treated by cytoreductive surgery with PIC. Complete cytoreductive surgery was achieved in 219 patients (73%), and hyperthermic intraperitoneal chemotherapy (HIPEC) was performed in 255 (85%), mainly during the latter period of the study...
May 2010: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/20087784/postoperative-pancreatic-fistula-after-cytoreductive-surgery-and-perioperative-intraperitoneal-chemotherapy-incidence-risk-factors-management-and-clinical-sequelae
#20
Akshat Saxena, Terence C Chua, Tristan D Yan, David L Morris
BACKGROUND: Cytoreductive surgery (CRS) and perioperative intraperitoneal chemotherapy (PIC) has improved survival in selected patients with peritoneal carcinomatosis. This study evaluates the morbidity of postoperative pancreatic fistula (PF) within the context of CRS and PIC. METHODS: Two hundred seventy-one consecutive CRS and PIC procedures were evaluated. Diagnosis and classification of postoperative PF were performed according to the international study group on PF criteria...
May 2010: Annals of Surgical Oncology
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