keyword
https://read.qxmd.com/read/37965334/neural-control-of-redox-response-and-microbiota-triggered-inflammation-in-drosophila-gut
#1
JOURNAL ARTICLE
Naoyuki Fuse, Haruka Hashiba, Kentaro Ishibashi, Takuro Suzuki, Quang-Dat Nguyen, Kiho Fujii, Wakako Ikeda-Ohtsubo, Haruki Kitazawa, Hiromu Tanimoto, Shoichiro Kurata
BACKGROUND: The neural system plays a critical role in controlling gut immunity, and the gut microbiota contributes to this process. However, the roles and mechanisms of gut-brain-microbiota interactions remain unclear. To address this issue, we employed Drosophila as a model organism. We have previously shown that NP3253 neurons, which are connected to the brain and gut, are essential for resistance to oral bacterial infections. Here, we aimed to investigate the role of NP3253 neurons in the regulation of gut immunity...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37817293/dilp8-and-its-candidate-receptor-drl-are-involved-in-the-transdetermination-of-the-drosophila-imaginal-disc
#2
JOURNAL ARTICLE
Kazuya Nemoto, Keita Masuko, Naoyuki Fuse, Shoichiro Kurata
Drosophila imaginal disc cells can change their identity under stress conditions through transdetermination (TD). Research on TD can help elucidate the in vivo process of cell fate conversion. We previously showed that the overexpression of winged eye (wge) induces eye-to-wing TD in the eye disc and that an insulin-like peptide, Dilp8, is then highly expressed in the disc. Although Dilp8 is known to mediate systemic developmental delay via the Lgr3 receptor, its role in TD remains unknown. This study showed that Dilp8 is expressed in specific cells that do not express eye or wing fate markers during Wge-mediated TD and that the loss of Dilp8 impairs the process of eye-to-wing transition...
October 10, 2023: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
https://read.qxmd.com/read/37317122/oral-administration-of-lacticaseibacillus-rhamnosus-crl1505-modulates-lung-innate-immune-response-against-klebsiella-pneumoniae-st25
#3
JOURNAL ARTICLE
Stefania Dentice Maidana, Yoshiya Imamura, Mariano Elean, Leonardo Albarracín, Keita Nishiyama, Yoshihito Suda, Shoichiro Kurata, María Ángela Jure, Haruki Kitazawa, Julio Villena
Orally administered Lacticaseibacillus rhamnosus CRL1505 enhances respiratory immunity, providing protection against respiratory viruses and Streptococcus pneumoniae . However, the capacity of the CRL1505 strain to improve respiratory immunity against Gram-negative bacterial infections has not been evaluated before. The aim of this work was to evaluate whether the Lcb. rhamnosus CRL1505 was able to beneficially regulate the respiratory innate immune response and enhance the resistance to hypermucoviscous KPC-2-producing Klebsiella pneumoniae of the sequence type 25 (ST25)...
April 28, 2023: Microorganisms
https://read.qxmd.com/read/37311618/re-recognition-of-innate-immune-memory-as-an-integrated-multidimensional-concept
#4
REVIEW
Chang Tang, Shoichiro Kurata, Naoyuki Fuse
In the past decade, the concept of immunological memory, which has long been considered a phenomenon observed in the adaptive immunity of vertebrates, has been extended to the innate immune system of various organisms. This de novo immunological memory is mainly called "innate immune memory", "immune priming", or "trained immunity" and has received increased attention because of its potential for clinical and agricultural applications. However, research on different species, especially invertebrates and vertebrates, has caused controversy regarding this concept...
June 13, 2023: Microbiology and Immunology
https://read.qxmd.com/read/37240146/hypermucoviscous-carbapenem-resistant-klebsiella-pneumoniae-st25-infect-human-intestinal-epithelial-cells-and-induce-moderate-inflammation
#5
JOURNAL ARTICLE
Stefania Dentice Maidana, Mariano Elean, Kohtaro Fukuyama, Yoshiya Imamura, Leonardo Albarracín, Sudeb Saha, Yoshihito Suda, Shoichiro Kurata, María Ángela Jure, Haruki Kitazawa, Julio Villena
Klebsiella pneumoniae is an opportunistic pathogen that can produce moderate and severe infections in immunosuppressed hosts. In recent years, an increase in the isolation of hypermucoviscous carbapenem-resistant K. pneumoniae with sequence type 25 (ST25) in hospitals in Norwest Argentina was observed. This work aimed to study the virulence and inflammatory potential of two K. pneumoniae ST25 strains (LABACER01 and LABACER27) in the intestinal mucosa. The human intestinal Caco-2 cells were infected with the K...
May 15, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36363777/the-ability-of-postimmunobiotics-from-l-rhamnosus-crl1505-to-protect-against-respiratory-syncytial-virus-and-pneumococcal-super-infection-is-a-strain-dependent-characteristic
#6
JOURNAL ARTICLE
Fernanda Raya Tonetti, Patricia Clua, Kohtaro Fukuyama, Guillermo Marcial, Jacinto Sacur, Gabriela Marranzino, Mikado Tomokiyo, Guadalupe Vizoso-Pinto, Apolinaria Garcia-Cancino, Shoichiro Kurata, Haruki Kitazawa, Julio Villena
Previously, we demonstrated that the non-viable strain Lacticaseibacillus rhamnosus CRL1505 (NV1505) or its purified peptidoglycan (PG1505) differentially modulated the respiratory innate antiviral immune response triggered by Toll-like receptor (TLR)-3 activation in infant mice, improving the resistance to primary respiratory syncytial virus (RSV) infection and secondary pneumococcal pneumonia. In this work, we evaluated the effect of other non-viable L. rhamnosus strains and their peptidoglycans on the respiratory immune response and their impact on primary and secondary respiratory infections...
November 3, 2022: Microorganisms
https://read.qxmd.com/read/36252180/transcriptome-features-of-innate-immune-memory-in-drosophila
#7
JOURNAL ARTICLE
Naoyuki Fuse, Chisaki Okamori, Ryoma Okaji, Chang Tang, Kikuko Hirai, Shoichiro Kurata
Immune memory is the ability of organisms to elicit potentiated immune responses at secondary infection. Current studies have revealed that similar to adaptive immunity, innate immunity exhibits memory characteristics (called "innate immune memory"). Although epigenetic reprogramming plays an important role in innate immune memory, the underlying mechanisms have not been elucidated, especially at the individual level. Here, we established experimental systems for detecting innate immune memory in Drosophila melanogaster...
October 2022: PLoS Genetics
https://read.qxmd.com/read/36145495/respiratory-commensal-bacteria-increase-protection-against-hypermucoviscous-carbapenem-resistant-klebsiella-pneumoniae-st25-infection
#8
JOURNAL ARTICLE
Stefania Dentice Maidana, Ramiro Ortiz Moyano, Juan Martin Vargas, Kohtaro Fukuyama, Shoichiro Kurata, Vyacheslav Melnikov, María Ángela Jure, Haruki Kitazawa, Julio Villena
In a previous work, we demonstrated that nasally administered Corynebacterium pseudodiphtheriticum 090104 beneficially modulated the respiratory innate immune response and improved the protection against Respiratory Syncytial Virus and Streptococcus pneumoniae in mice. In this work, we aimed to evaluate whether the immunomodulatory 090104 strain was able to enhance the resistance against the respiratory infection induced by hypermucoviscous carbapenemase-producing (KPC-2) Klebsiella pneumoniae strains belonging to the sequence type (ST) 25...
September 19, 2022: Pathogens
https://read.qxmd.com/read/35990631/genetic-dissection-of-innate-immune-memory-in-drosophila-melanogaster
#9
JOURNAL ARTICLE
Chang Tang, Shoichiro Kurata, Naoyuki Fuse
Current studies have demonstrated that innate immunity possesses memory characteristics. Although the molecular mechanisms underlying innate immune memory have been addressed by numerous studies, genetic variations in innate immune memory and the associated genes remain unclear. Here, we explored innate immune memory in 163 lines of Drosophila melanogaster from the Drosophila Synthetic Population Resource. In our assay system, prior training with low pathogenic bacteria ( Micrococcus luteus ) increased the survival rate of flies after subsequent challenge with highly pathogenic bacteria ( Staphylococcus aureus )...
2022: Frontiers in Immunology
https://read.qxmd.com/read/35806365/genomic-and-immunological-characterization-of-hypermucoviscous-carbapenem-resistant-klebsiella-pneumoniae-st25-isolates-from-northwest-argentina
#10
JOURNAL ARTICLE
Leonardo Albarracin, Ramiro Ortiz Moyano, Juan Martin Vargas, Bruno G N Andrade, Juan Cortez Zamar, Stefania Dentice Maidana, Kohtaro Fukuyama, Shoichiro Kurata, María Ángela Jure, Haruki Kitazawa, Julio Villena
In recent years, an increase in the prevalence hypermucoviscous carbapenem-resistant Klebsiella pneumoniae with sequence type 25 (ST25) was detected in hospitals of Tucuman (Northwest Argentina). In this work, the virulence and the innate immune response to two K. pneumoniae ST25 strains (LABACER 01 and LABACER 27) were evaluated in a murine model after a respiratory challenge. In addition, comparative genomics was performed with K. pneumoniae LABACER01 and LABACER27 to analyze genes associated with virulence...
July 1, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/34988396/cgmp-signaling-pathway-that-modulates-nf-%C3%AE%C2%BAb-activation-in-innate-immune-responses
#11
JOURNAL ARTICLE
Hirotaka Kanoh, Shinzo Iwashita, Takayuki Kuraishi, Akira Goto, Naoyuki Fuse, Haruna Ueno, Mariko Nimura, Tomohito Oyama, Chang Tang, Ryo Watanabe, Aki Hori, Yoshiki Momiuchi, Hiroki Ishikawa, Hiroaki Suzuki, Kumiko Nabe, Takeshi Takagaki, Masataka Fukuzaki, Li-Li Tong, Sinya Yamada, Yoshiteru Oshima, Toshiro Aigaki, Julian A T Dow, Shireen-Anne Davies, Shoichiro Kurata
The nuclear factor-kappa B (NF-κB) pathway is an evolutionarily conserved signaling pathway that plays a central role in immune responses and inflammation. Here, we show that Drosophila NF-κB signaling is activated via a pathway in parallel with the Toll receptor by receptor-type guanylate cyclase, Gyc76C. Gyc76C produces cyclic guanosine monophosphate (cGMP) and modulates NF-κB signaling through the downstream Tollreceptor components dMyd88, Pelle, Tube, and Dif/Dorsal (NF-κB). The cGMP signaling pathway comprises a membrane-localized cGMP-dependent protein kinase (cGK) called DG2 and protein phosphatase 2A (PP2A) and is crucial for host survival against Gram-positive bacterial infections in Drosophila ...
December 17, 2021: IScience
https://read.qxmd.com/read/34207076/the-respiratory-commensal-bacterium-dolosigranulum-pigrum-040417-improves-the-innate-immune-response-to-streptococcus-pneumoniae
#12
JOURNAL ARTICLE
Fernanda Raya Tonetti, Mikado Tomokiyo, Ramiro Ortiz Moyano, Sandra Quilodrán-Vega, Hikari Yamamuro, Paulraj Kanmani, Vyacheslav Melnikov, Shoichiro Kurata, Haruki Kitazawa, Julio Villena
Previously, we demonstrated that the nasal administration of Dolosigranulum pigrum 040417 differentially modulated the respiratory innate immune response triggered by the activation of Toll-like receptor 2 in infant mice. In this work, we aimed to evaluate the beneficial effects of D. pigrum 040417 in the context of Streptococcus pneumoniae infection and characterize the role of alveolar macrophages (AMs) in the immunomodulatory properties of this respiratory commensal bacterium. The nasal administration of D...
June 18, 2021: Microorganisms
https://read.qxmd.com/read/34163470/-ligilactobacillus-salivarius-strains-isolated-from-the-porcine-gut-modulate-innate-immune-responses-in-epithelial-cells-and-improve-protection-against-intestinal-viral-bacterial-superinfection
#13
JOURNAL ARTICLE
Yuhki Indo, Shugo Kitahara, Mikado Tomokiyo, Shota Araki, Md Aminul Islam, Binghui Zhou, Leonardo Albarracin, Ayako Miyazaki, Wakako Ikeda-Ohtsubo, Tomonori Nochi, Takato Takenouchi, Hirohide Uenishi, Hisashi Aso, Hideki Takahashi, Shoichiro Kurata, Julio Villena, Haruki Kitazawa
Previously, we constructed a library of Ligilactobacillus salivarius strains from the intestine of wakame-fed pigs and reported a strain-dependent capacity to modulate IFN-β expression in porcine intestinal epithelial (PIE) cells. In this work, we further characterized the immunomodulatory activities of L. salivarius strains from wakame-fed pigs by evaluating their ability to modulate TLR3- and TLR4-mediated innate immune responses in PIE cells. Two strains with a remarkable immunomodulatory potential were selected: L...
2021: Frontiers in Immunology
https://read.qxmd.com/read/33400912/homeostatic-regulation-of-ros-triggered-hippo-yki-pathway-via-autophagic-clearance-of-ref-2-p-p62-in-the-drosophila-intestine
#14
JOURNAL ARTICLE
Hiroki Nagai, Hiroshi Tatara, Kyoko Tanaka-Furuhashi, Shoichiro Kurata, Tamaki Yano
Homeostasis of intestinal epithelia is maintained by coordination of the proper rate of regeneration by stem cell division with the rate of cell loss. Regeneration of host epithelia is normally quiescent upon colonization of commensal bacteria; however, the epithelia often develop dysplasia in a context-dependent manner, the cause and underlying mechanism of which remain unclear. Here, we show that in Drosophila intestine, autophagy lowers the sensitivity of differentiated enterocytes to reactive oxygen species (ROS) that are produced in response to commensal bacteria...
January 11, 2021: Developmental Cell
https://read.qxmd.com/read/33114778/selection-of-immunobiotic-ligilactobacillus-salivarius-strains-from-the-intestinal-tract-of-wakame-fed-pigs-functional-and-genomic-studies
#15
JOURNAL ARTICLE
Binghui Zhou, Leonardo Albarracin, Yuhki Indo, Lorena Arce, Yuki Masumizu, Mikado Tomokiyo, Md Aminul Islam, Valeria Garcia-Castillo, Wakako Ikeda-Ohtsubo, Tomonori Nochi, Hidetoshi Morita, Hideki Takahashi, Shoichiro Kurata, Julio Villena, Haruki Kitazawa
In this article, Ligilactobacillus salivarius FFIG strains, isolated from the intestinal tract of wakame-fed pigs, are characterized according to their potential probiotic properties. Strains were evaluated by studying their interaction with porcine intestinal epithelial (PIE) cells in terms of their ability to regulate toll-like receptor (TLR)-3- or TLR4-mediated innate immune responses, as well as by assessing their adhesion capabilities to porcine epithelial cells and mucins. These functional studies were complemented with comparative genomic evaluations using the complete genome sequences of porcine L...
October 26, 2020: Microorganisms
https://read.qxmd.com/read/32708530/erratum-fukuyama-k-et-al-evaluation-of-the-immunomodulatory-ability-of-lactic-acid-bacteria-isolated-from-feedlot-cattle-against-mastitis-using-a-bovine-mammary-epithelial-cells-in-vitro-assay-pathogens-2020-9-410
#16
Kohtaro Fukuyama, Md Aminul Islam, Michihiro Takagi, Wakako Ikeda-Ohtsubo, Shoichiro Kurata, Hisashi Aso, Maria Elena Fatima Nader-Macías, Graciela Vignolo, Julio Villena, Haruki Kitazawa
The authors would like to make the following corrections about the published paper [...].
July 16, 2020: Pathogens
https://read.qxmd.com/read/32660087/the-role-of-alveolar-macrophages-in-the-improved-protection-against-respiratory-syncytial-virus-and-pneumococcal-superinfection-induced-by-the-peptidoglycan-of-lactobacillus-rhamnosus-crl1505
#17
JOURNAL ARTICLE
Patricia Clua, Mikado Tomokiyo, Fernanda Raya Tonetti, Md Aminul Islam, Valeria García Castillo, Guillermo Marcial, Susana Salva, Susana Alvarez, Hideki Takahashi, Shoichiro Kurata, Haruki Kitazawa, Julio Villena
The nasal priming with nonviable Lactobacillus rhamnosus CRL1505 (NV1505) or its purified peptidoglycan (PG1505) differentially modulates the respiratory innate immune response in infant mice, improving their resistance to primary respiratory syncytial virus (RSV) infection and secondary pneumococcal pneumonia. In association with the protection against RSV-pneumococcal superinfection, it was found that NV1505 or PG1505 significantly enhance the numbers of CD11c+ SiglecF+ alveolar macrophages (AMs) producing interferon (IFN)-β...
July 9, 2020: Cells
https://read.qxmd.com/read/32466097/evaluation-of-the-immunomodulatory-ability-of-lactic-acid-bacteria-isolated-from-feedlot-cattle-against-mastitis-using-a-bovine-mammary-epithelial-cells-in-vitro-assay
#18
JOURNAL ARTICLE
Kohtaro Fukuyama, Md Aminul Islam, Michihiro Takagi, Wakako Ikeda-Ohtsubo, Shoichiro Kurata, Hisashi Aso, Graciela Vignolo, Julio Villena, Haruki Kitazawa
Bovine mastitis, the inflammation of the mammary gland, affects the quality and quantity of milk yield. Mastitis control relies on single or multiple combinations of antibiotic therapy. Due to increasing antibiotic resistance in pathogens, the intramammary infusion of lactic acid bacteria (LAB) has been considered as a potential alternative to antibiotics for treating and preventing bovine mastitis through the improvement of the host immunity. Probiotic effects are a strain-dependent characteristic; therefore, candidate LAB strains have to be evaluated efficiently to find out the ones with the best potential...
May 25, 2020: Pathogens
https://read.qxmd.com/read/32414154/the-ability-of-respiratory-commensal-bacteria-to-beneficially-modulate-the-lung-innate-immune-response-is-a-strain-dependent-characteristic
#19
JOURNAL ARTICLE
Ramiro Ortiz Moyano, Fernanda Raya Tonetti, Mikado Tomokiyo, Paulraj Kanmani, María Guadalupe Vizoso-Pinto, Hojun Kim, Sandra Quilodrán-Vega, Vyacheslav Melnikov, Susana Alvarez, Hideki Takahashi, Shoichiro Kurata, Haruki Kitazawa, Julio Villena
We investigated whether the ability of commensal respiratory bacteria to modulate the innate immune response against bacterial and viral pathogens was a shared or strain-specific characteristic. Bacterial strains belonging to the Corynebacterium pseudodiphtheriticum and Dolosigranulum pigrum species were compared by studying their influence in the Toll-like receptor (TLR)-2- and TLR3-triggered immune responses in the respiratory tract, as well as in the resistance to Respiratory Syncytial Virus (RSV) and Streptococcus pneumoniae infections...
May 13, 2020: Microorganisms
https://read.qxmd.com/read/32080940/immunoglobulin-superfamily-beat-ib-mediates-intestinal-regeneration-induced-by-reactive-oxygen-species-in-drosophila
#20
JOURNAL ARTICLE
Hiroki Nagai, Shoichiro Kurata, Tamaki Yano
Reactive oxygen species (ROS) often injure intestinal epithelia that cause loss of damaged cells, which is mainly repaired by proliferation of intestinal stem cells (ISCs). To maintain the homeostatic state, coordination of sensing of the ROS injury and the subsequent epithelial cell loss with the replenishment by cell renewal is crucial. However, little is known about how gut epithelial cells initiate regenerative responses against ROS to maintain the tissue integrity. Here, we performed a genome-wide screen, by which we identify immunoglobulin superfamily beaten path Ib (beat-Ib) as an essential gene for provoking ISC proliferation against ROS in Drosophila intestine...
February 20, 2020: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
keyword
keyword
116016
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.